E. Özdemir, F. Familiari, P. Huri, A. Fırat, G. Huri
3D-printed (3DP) polycaprolactone (PCL)-based scaffolds have gained popularity in the past decade. Despite the wide utility of autografts for bone regeneration in orthopedics practice, 3DP PCL scaffolds may replace this general application. Here we present a 42-year-old patient who had glenohumeral arthritis due to rheumatoid arthritis accompanied by a Walch 3 glenoid defect, and a 19-year-old patient with neglected Galeazzi fracture–dislocation accompanied by a radius non-union. In both patients, a 3DP PCL + hyaluronic acid-based scaffold was used for bone regeneration purposes. The preliminary results showed that the 3DP PCL + hyaluronic acid scaffold provided bone regeneration and may be a promising alternative to autografting for bone regeneration in orthopedic practice.
{"title":"Use of 3D-printed polycaprolactone + hyaluronic acid-based scaffold in orthopedic practice: report of two cases","authors":"E. Özdemir, F. Familiari, P. Huri, A. Fırat, G. Huri","doi":"10.2217/3dp-2022-0020","DOIUrl":"https://doi.org/10.2217/3dp-2022-0020","url":null,"abstract":"3D-printed (3DP) polycaprolactone (PCL)-based scaffolds have gained popularity in the past decade. Despite the wide utility of autografts for bone regeneration in orthopedics practice, 3DP PCL scaffolds may replace this general application. Here we present a 42-year-old patient who had glenohumeral arthritis due to rheumatoid arthritis accompanied by a Walch 3 glenoid defect, and a 19-year-old patient with neglected Galeazzi fracture–dislocation accompanied by a radius non-union. In both patients, a 3DP PCL + hyaluronic acid-based scaffold was used for bone regeneration purposes. The preliminary results showed that the 3DP PCL + hyaluronic acid scaffold provided bone regeneration and may be a promising alternative to autografting for bone regeneration in orthopedic practice.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73031022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Assessment of the imaging properties of 3D-printable materials using dual energy computed tomography (DECT) to match clinical values for imaging phantoms. Methods: 3D-printed samples were imaged using DECT. Regions of interest were analyzed to assess spectral computed tomography (CT) numbers at various energies and measure the electron density (ρe) and effective atomic number (Zeff). Results: Electron density was proportional to the CT number for the materials assessed with Zeff between 6.43 and 7.01. The measured CT number increased with monochromatic energy for all but one sample. Conclusion: A single DECT scan provides valuable information regarding the properties of 3D-printable material due to the ease of measurement of ρe and Zeff. The majority of 3D-printed materials analyzed behaved like adipose tissue across a range of energies in CT imaging.
{"title":"Assessment of the imaging properties of 3D-printable material using dual energy computed tomography","authors":"Lisa M Rowley, Elizabeth Davies, Emma Chung","doi":"10.2217/3dp-2022-0019","DOIUrl":"https://doi.org/10.2217/3dp-2022-0019","url":null,"abstract":"Aim: Assessment of the imaging properties of 3D-printable materials using dual energy computed tomography (DECT) to match clinical values for imaging phantoms. Methods: 3D-printed samples were imaged using DECT. Regions of interest were analyzed to assess spectral computed tomography (CT) numbers at various energies and measure the electron density (ρe) and effective atomic number (Zeff). Results: Electron density was proportional to the CT number for the materials assessed with Zeff between 6.43 and 7.01. The measured CT number increased with monochromatic energy for all but one sample. Conclusion: A single DECT scan provides valuable information regarding the properties of 3D-printable material due to the ease of measurement of ρe and Zeff. The majority of 3D-printed materials analyzed behaved like adipose tissue across a range of energies in CT imaging.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"27 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87658569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Total ear reconstruction describes surgical approaches aimed toward restoring the external ear to correct acquired or congenital deformities. Frameworks for auricular reconstruction have undergone substantial evolution over the past century and are broadly categorized as either autologous or alloplastic in nature. Recently, advances in tissue engineering, regenerative medicine and materials science have opened new avenues for recreating the cartilaginous and soft tissue structures of the ear through development of cutting-edge 3D constructs derived from a patient's own cells in a process known as bioprinting. This review outlines the historical approaches to frameworks for ear reconstruction and provides an updated synopsis and appraisal of current bioprinting efforts.
{"title":"Frameworks for total ear reconstruction: past, present and future directions","authors":"Luke B Soliman, M. Borrelli, Nikhil Sobti, A. Woo","doi":"10.2217/3dp-2022-0018","DOIUrl":"https://doi.org/10.2217/3dp-2022-0018","url":null,"abstract":"Total ear reconstruction describes surgical approaches aimed toward restoring the external ear to correct acquired or congenital deformities. Frameworks for auricular reconstruction have undergone substantial evolution over the past century and are broadly categorized as either autologous or alloplastic in nature. Recently, advances in tissue engineering, regenerative medicine and materials science have opened new avenues for recreating the cartilaginous and soft tissue structures of the ear through development of cutting-edge 3D constructs derived from a patient's own cells in a process known as bioprinting. This review outlines the historical approaches to frameworks for ear reconstruction and provides an updated synopsis and appraisal of current bioprinting efforts.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88491479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cryobioprinting for biomedical applications","authors":"Hossein Ravanbakhsh, Y. S. Zhang","doi":"10.2217/3dp-2022-0017","DOIUrl":"https://doi.org/10.2217/3dp-2022-0017","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80917802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph Smith, Nicholas N. DePhillipo, Shannon L. David, Katelyn Nicolay, Sofia Wentz, Abby Steckler, Connor Westberg
Aim: To evaluate the reliability, validity, and feasibility of 3D-printed short arm casts (SACs) versus conventional casts. Methods: Three raters of varying experience applied two conventional and two 3D-printed casts to a participant's dominant wrist to evaluate reliability. Each cast was worn for 24 hours and removed the following day after data collection. Results & conclusion: ICCs demonstrated ‘excellent’ intra-rater reliability for clinical effectiveness and patient satisfaction. There were no significant differences between fiberglass and 3D-printed SACs. The 3D-printed SAC group had significantly higher wrist function compared with the fiberglass SAC group. Discussion: This pilot case study demonstrates that 3D-printed short arm casts may be a valid immobilization technique of the wrist compared with conventional waterproof fiberglass casting.
{"title":"3D-printed short arm casts: reliability, validity, feasibility compared with conventional waterproof fiberglass casts","authors":"Joseph Smith, Nicholas N. DePhillipo, Shannon L. David, Katelyn Nicolay, Sofia Wentz, Abby Steckler, Connor Westberg","doi":"10.2217/3dp-2022-0015","DOIUrl":"https://doi.org/10.2217/3dp-2022-0015","url":null,"abstract":"Aim: To evaluate the reliability, validity, and feasibility of 3D-printed short arm casts (SACs) versus conventional casts. Methods: Three raters of varying experience applied two conventional and two 3D-printed casts to a participant's dominant wrist to evaluate reliability. Each cast was worn for 24 hours and removed the following day after data collection. Results & conclusion: ICCs demonstrated ‘excellent’ intra-rater reliability for clinical effectiveness and patient satisfaction. There were no significant differences between fiberglass and 3D-printed SACs. The 3D-printed SAC group had significantly higher wrist function compared with the fiberglass SAC group. Discussion: This pilot case study demonstrates that 3D-printed short arm casts may be a valid immobilization technique of the wrist compared with conventional waterproof fiberglass casting.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76540608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanket Shah, Natalie Behrle, M. Salek, Masoud Farahmand, Anmol Goyal, A. Divekar, Ethan O. Kung
Aim: Patient-specific fluid dynamic simulation of pulmonary arteries can be a valuable tool in pre-procedural planning. Materials & methods: For three patients, soft, deformable models of the pulmonary arteries were 3D printed from cardiac magnetic resonance data. In vitro hemodynamics were replicated using a gear flow pump, 40% glycerol solution and a physical Windkessel module. The pulmonary pressures were compared with patient cardiac catheterization pressure. Results: The pulmonary artery pressures and flow volumes had an adequate goodness of fit except for pulmonary pressures in patient 2. Conclusion: Cardiac magnetic resonance angiogram and flow volume data can be leveraged to generate a patient-specific 3D model and reproduce in vivo hemodynamics by means of in vitro simulation.
{"title":"Reproducing patient-specific 3D-model of pulmonary artery hemodynamics by means of in vitro benchtop simulation","authors":"Sanket Shah, Natalie Behrle, M. Salek, Masoud Farahmand, Anmol Goyal, A. Divekar, Ethan O. Kung","doi":"10.2217/3dp-2022-0004","DOIUrl":"https://doi.org/10.2217/3dp-2022-0004","url":null,"abstract":"Aim: Patient-specific fluid dynamic simulation of pulmonary arteries can be a valuable tool in pre-procedural planning. Materials & methods: For three patients, soft, deformable models of the pulmonary arteries were 3D printed from cardiac magnetic resonance data. In vitro hemodynamics were replicated using a gear flow pump, 40% glycerol solution and a physical Windkessel module. The pulmonary pressures were compared with patient cardiac catheterization pressure. Results: The pulmonary artery pressures and flow volumes had an adequate goodness of fit except for pulmonary pressures in patient 2. Conclusion: Cardiac magnetic resonance angiogram and flow volume data can be leveraged to generate a patient-specific 3D model and reproduce in vivo hemodynamics by means of in vitro simulation.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73202575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Palmon, Ross E Michaels, J. Claflin, Maya Behrend, D. Zopf, S. Waits
Objective: Our team set out to design and develop a low-cost 3D-printed liver transplant simulator. Design: The simulator comprises a 3D-printed recipient body cavity and the filled-fabric liver. Results: Validators perceived the model as valuable to education, noted that they would use the model at their institution and desired to integrate the model into their curriculum. In addition, the simulator was rated highly for ease of use (3.6/4), physical attributes (3.2/4) and user experience (4.4/5). Conclusion: The low-cost 3D-printed simulator for liver transplantation was highly rated in a multi-institutional validation and supports the use of simulation models in transplant surgery.
{"title":"Design, development and multi-institutional validation of a low-cost 3D-printed liver transplant simulator","authors":"I. Palmon, Ross E Michaels, J. Claflin, Maya Behrend, D. Zopf, S. Waits","doi":"10.2217/3dp-2022-0011","DOIUrl":"https://doi.org/10.2217/3dp-2022-0011","url":null,"abstract":"Objective: Our team set out to design and develop a low-cost 3D-printed liver transplant simulator. Design: The simulator comprises a 3D-printed recipient body cavity and the filled-fabric liver. Results: Validators perceived the model as valuable to education, noted that they would use the model at their institution and desired to integrate the model into their curriculum. In addition, the simulator was rated highly for ease of use (3.6/4), physical attributes (3.2/4) and user experience (4.4/5). Conclusion: The low-cost 3D-printed simulator for liver transplantation was highly rated in a multi-institutional validation and supports the use of simulation models in transplant surgery.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: This study aimed to investigate the optimal computed tomography angiography (CTA) scanning protocols in patients with aortic dissection following thoracic endovascular aortic repair. Materials & methods: A patient-specific aortic dissection model was CT scanned at different tube voltages (80, 100 and 120 kVp) and pitch values (1.2, 1.5, 2.0 and 2.5). Six radiologists and ten radiological technologists were invited to assess images in terms of both image quality and diagnostic value. Results & conclusion: The protocol of 80 kVp with 2.0 pitch resulted in highest subjective scores with lowest dose value compared with other protocols. This study concludes that low tube voltage with high pitch (CTA) using 3D-printed model produces adequate image quality while reducing radiation dose.
{"title":"Assessment of optimization of computed tomography angiography protocols for follow-up type B aortic dissection patients by using a 3D-printed model","authors":"Chia-An Wu, A. Squelch, Zhonghua Sun","doi":"10.2217/3dp-2022-0006","DOIUrl":"https://doi.org/10.2217/3dp-2022-0006","url":null,"abstract":"Aim: This study aimed to investigate the optimal computed tomography angiography (CTA) scanning protocols in patients with aortic dissection following thoracic endovascular aortic repair. Materials & methods: A patient-specific aortic dissection model was CT scanned at different tube voltages (80, 100 and 120 kVp) and pitch values (1.2, 1.5, 2.0 and 2.5). Six radiologists and ten radiological technologists were invited to assess images in terms of both image quality and diagnostic value. Results & conclusion: The protocol of 80 kVp with 2.0 pitch resulted in highest subjective scores with lowest dose value compared with other protocols. This study concludes that low tube voltage with high pitch (CTA) using 3D-printed model produces adequate image quality while reducing radiation dose.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72516060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Feltz, L. MacFadden, Samuel D. Gieg, C. Lough, W. Bezold, N. Skelley
Aim: 3D printing is a growing technology with promising applications in orthopedic surgery. However, the utilization of 3D-printed surgical implants has not been fully explored. Materials & methods: One-third tubular plates and cortical screws were printed via fused deposition modeling using four materials: acrylonitrile butadiene styrene, carbon fiber-reinforced polylactic acid, polycarbonate and polyether ether ketone. Plates were analyzed with three-point bending and torque testing, and screws underwent torque, shear and pullout testing. Results: Two-factor Analysis of Variance (ANOVA) demonstrated several significant differences between mechanical profiles for different materials and between designs. Conclusion: The results demonstrate that desktop 3D printers can print biocompatible materials to replicate surgical implant designs at a low cost. However, current materials and structures do not approximate the properties of stainless-steel implants.
{"title":"Mechanical properties of 3D-printed orthopedic one-third tubular plates and cortical screws","authors":"K. Feltz, L. MacFadden, Samuel D. Gieg, C. Lough, W. Bezold, N. Skelley","doi":"10.2217/3dp-2022-0007","DOIUrl":"https://doi.org/10.2217/3dp-2022-0007","url":null,"abstract":"Aim: 3D printing is a growing technology with promising applications in orthopedic surgery. However, the utilization of 3D-printed surgical implants has not been fully explored. Materials & methods: One-third tubular plates and cortical screws were printed via fused deposition modeling using four materials: acrylonitrile butadiene styrene, carbon fiber-reinforced polylactic acid, polycarbonate and polyether ether ketone. Plates were analyzed with three-point bending and torque testing, and screws underwent torque, shear and pullout testing. Results: Two-factor Analysis of Variance (ANOVA) demonstrated several significant differences between mechanical profiles for different materials and between designs. Conclusion: The results demonstrate that desktop 3D printers can print biocompatible materials to replicate surgical implant designs at a low cost. However, current materials and structures do not approximate the properties of stainless-steel implants.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"366 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77331030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Benady, J. S. Meyer, Dor Freidin, Yuval Ran, E. Golden, K. Wong, S. Dadia
Over the past four decades, advancements in adjuvant treatments of bone sarcomas have catalyzed development of novel surgical technologies that continue to improve limb salvage surgeries. To date, these technologies have made limb salvage surgery the mainstay of treatment, while limb amputations became negligible. These advancements include pre-and intra-operative imaging technologies enabling accurate 3D-preoperative planning, and intraoperative patient-specific instruments allowing accurate execution of surgical plans. The introduction of customized 3D-printed porous titanium implants gave surgeons more freedom to retain surrounding healthy tissue and optimize reconstruction fit, thereby improving quality of life and reducing comorbidities post-operatively. Creating these custom implants has brought forth novel processes, materials and technologies and given rise to a new era in orthopedic oncology.
{"title":"A review of 3D printing in orthopedic oncology","authors":"Amit Benady, J. S. Meyer, Dor Freidin, Yuval Ran, E. Golden, K. Wong, S. Dadia","doi":"10.2217/3dp-2022-0001","DOIUrl":"https://doi.org/10.2217/3dp-2022-0001","url":null,"abstract":"Over the past four decades, advancements in adjuvant treatments of bone sarcomas have catalyzed development of novel surgical technologies that continue to improve limb salvage surgeries. To date, these technologies have made limb salvage surgery the mainstay of treatment, while limb amputations became negligible. These advancements include pre-and intra-operative imaging technologies enabling accurate 3D-preoperative planning, and intraoperative patient-specific instruments allowing accurate execution of surgical plans. The introduction of customized 3D-printed porous titanium implants gave surgeons more freedom to retain surrounding healthy tissue and optimize reconstruction fit, thereby improving quality of life and reducing comorbidities post-operatively. Creating these custom implants has brought forth novel processes, materials and technologies and given rise to a new era in orthopedic oncology.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74992654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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