E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger
Introduction: The present study aimed to review the acute and long-term variations in variables related to redox, inflammation and hormonal status in male footballers. Materials and methods: A PRISMA-compliant systematic review was conducted. The entire content of PubMed, Scopus and Science Direct were systematically searched until May 2022. Studies with outcomes including: (1) adult male football players, (2) a redox and/or an inflammatory and/or a hormonal marker after a training period, and (3) variables measured in blood/saliva. Results: Thirty-four studies met the inclusion criteria for the qualitative synthesis. Fourteen studies on redox status, 16 on inflammation/muscle damage and 20 on hormonal variations. Only 4 studies incorporated markers related to all 3 statuses, while 8 studies looked at a combination of 2. Studies around redox homeostasis found several markers to fluctuate with MDA, TBARS, protein carbonyls, GSSG, GPx, CAT, and uric acid increasing immediately after a game. Hormonal markers, such as testosterone in blood, revealed no significant change after training. Some found T to increase post-exercise, and some a decrease. Cortisol increased in both short- and long monitoring periods. Markers associated with inflammation and muscle damage found creatine kinase elevated immediately post-game and over extended periods. LDH, C-RP, and IL-6 were also higher post-match. Discussion: Exposure to short or long-term participation in football training and competitions could significantly affect footballers' redox, inflammation and hormonal status. However, greater consistency across studies is required to ascertain the implications of structured training regimens on measured variables. Selecting the most relevant protocol/ conditions and biochemical markers, including the collection time and the type of specimen, must be considered.
{"title":"Acute and Long-Term Variations in Variables Related to Redox, Inflammation and Hormonal Status in Male Football Players: A Systematic Review and Recommendations","authors":"E. Varamenti, Catherine E. Beattie, D. Tod, T. Bommasamudram, C. Savoia, S. Pullinger","doi":"10.26502/josm.511500062","DOIUrl":"https://doi.org/10.26502/josm.511500062","url":null,"abstract":"Introduction: The present study aimed to review the acute and long-term variations in variables related to redox, inflammation and hormonal status in male footballers. Materials and methods: A PRISMA-compliant systematic review was conducted. The entire content of PubMed, Scopus and Science Direct were systematically searched until May 2022. Studies with outcomes including: (1) adult male football players, (2) a redox and/or an inflammatory and/or a hormonal marker after a training period, and (3) variables measured in blood/saliva. Results: Thirty-four studies met the inclusion criteria for the qualitative synthesis. Fourteen studies on redox status, 16 on inflammation/muscle damage and 20 on hormonal variations. Only 4 studies incorporated markers related to all 3 statuses, while 8 studies looked at a combination of 2. Studies around redox homeostasis found several markers to fluctuate with MDA, TBARS, protein carbonyls, GSSG, GPx, CAT, and uric acid increasing immediately after a game. Hormonal markers, such as testosterone in blood, revealed no significant change after training. Some found T to increase post-exercise, and some a decrease. Cortisol increased in both short- and long monitoring periods. Markers associated with inflammation and muscle damage found creatine kinase elevated immediately post-game and over extended periods. LDH, C-RP, and IL-6 were also higher post-match. Discussion: Exposure to short or long-term participation in football training and competitions could significantly affect footballers' redox, inflammation and hormonal status. However, greater consistency across studies is required to ascertain the implications of structured training regimens on measured variables. Selecting the most relevant protocol/ conditions and biochemical markers, including the collection time and the type of specimen, must be considered.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-09-05DOI: 10.26502/josm.511500060
Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi
The rat animal model is a cost effective and reliable model used in spinal pre-clinical research. Complications from various surgical procedures in humans often arise that were based on these pre-clinical animal models. Therefore safe and efficacious pre-clinical animal models are needed to establish continuity into clinical trials. A Standard Operating Procedure (SOP) is a validated method that allows researchers to safely and carefully replicate previously successful surgical techniques. Thus, the aim of this study is to describe in detail the procedures involved in a common rat bilateral posterolateral intertransverse spinal fusion SOP used to test the efficacy and safety different orthobiologics using a collagen-soaked sponge as an orthobiologic carrier. Only two orthobiologics are currently FDA approved for spinal fusion surgery which include recombinant bone morphogenetic protein 2 (rhBMP-2), and I-FACTOR. While there are many additional orthobiologics currently being tested, one way to show their safety profile and gain FDA approval, is to use well established pre-clinical animal models. A preoperative, intraoperative, and postoperative surgical setup including specific anesthesia and euthanasia protocols are outlined. Furthermore, we describe different postoperative methods used to validate the spinal fusion SOP, which include μCT analysis, histopathology, biomechanical testing, and blood analysis. This SOP can help increase validity, transparency, efficacy, and reproducibly in future rat spinal fusion surgery procedures.
{"title":"A Pre-clinical Standard Operating Procedure for Evaluating Orthobiologics in an <i>In Vivo</i> Rat Spinal Fusion Model.","authors":"Andrew L Alejo, Scott McDermott, Yusuf Khalil, Hope C Ball, Gabrielle T Robinson, Ernesto Solorzano, Amanda M Alejo, Jacob Douglas, Trinity K Samson, Jesse W Young, Fayez F Safadi","doi":"10.26502/josm.511500060","DOIUrl":"10.26502/josm.511500060","url":null,"abstract":"<p><p>The rat animal model is a cost effective and reliable model used in spinal pre-clinical research. Complications from various surgical procedures in humans often arise that were based on these pre-clinical animal models. Therefore safe and efficacious pre-clinical animal models are needed to establish continuity into clinical trials. A Standard Operating Procedure (SOP) is a validated method that allows researchers to safely and carefully replicate previously successful surgical techniques. Thus, the aim of this study is to describe in detail the procedures involved in a common rat bilateral posterolateral intertransverse spinal fusion SOP used to test the efficacy and safety different orthobiologics using a collagen-soaked sponge as an orthobiologic carrier. Only two orthobiologics are currently FDA approved for spinal fusion surgery which include recombinant bone morphogenetic protein 2 (rhBMP-2), and I-FACTOR. While there are many additional orthobiologics currently being tested, one way to show their safety profile and gain FDA approval, is to use well established pre-clinical animal models. A preoperative, intraoperative, and postoperative surgical setup including specific anesthesia and euthanasia protocols are outlined. Furthermore, we describe different postoperative methods used to validate the spinal fusion SOP, which include <i>μ</i>CT analysis, histopathology, biomechanical testing, and blood analysis. This SOP can help increase validity, transparency, efficacy, and reproducibly in future rat spinal fusion surgery procedures.</p>","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534599/pdf/nihms-1837082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33509493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper provides a brief review of how wars in recent history have shaped the development of rheumatology as a medical specialty. This history is not widely known in the medical field and appears to have been forgotten. However, it is important to the field of both military medicine and rheumatology in a civilian context. Many rheumatic diseases were recognised for the first time as a result of doctors treating arthritis in soldiers during World War I and World War II. Chemical Weapons in both wars lead to the discovery of many Disease Modifying Anti Rheumatic Drugs still commonly used today in rheumatology. During World War I, 93,000 cases of arthritis were reported in US troops. Ten years after the end of World War I in the US, the government was paying $10,000,000 a year to around 35,000 ex-service personnel for disabilities as a result of chronic arthritis, demonstrating arthritis in military history is significant.
{"title":"Out of the Trenches: A Review of Modern Rheumatology’s Relationship with War","authors":"M. Alexander","doi":"10.26502/josm.511500071","DOIUrl":"https://doi.org/10.26502/josm.511500071","url":null,"abstract":"This paper provides a brief review of how wars in recent history have shaped the development of rheumatology as a medical specialty. This history is not widely known in the medical field and appears to have been forgotten. However, it is important to the field of both military medicine and rheumatology in a civilian context. Many rheumatic diseases were recognised for the first time as a result of doctors treating arthritis in soldiers during World War I and World War II. Chemical Weapons in both wars lead to the discovery of many Disease Modifying Anti Rheumatic Drugs still commonly used today in rheumatology. During World War I, 93,000 cases of arthritis were reported in US troops. Ten years after the end of World War I in the US, the government was paying $10,000,000 a year to around 35,000 ex-service personnel for disabilities as a result of chronic arthritis, demonstrating arthritis in military history is significant.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhifeng Wang, C. Han, C. Yuan, Yiyuan Shen, X. Geng, Chen Wang, Chao Zhang, Jiazhang Huang, Xin Ma, Hanqiu Liu, Xu Wang
Background : Evidence of altered brain functional activation in response to different tasks has been reported in some peripheral neuropathies. The aim of this study was to investigate possible central nervous system modifications using task-state Functional Magnetic Resonance Imaging (FMRI) in Charcot–Marie–Tooth patients. Methods: A design of ankle dorsiflexion-plantarflexion and fist clutching paradigm was adopted at a frequency of 1 Hz in the FMRI portion in CMT patients and healthy controls. We acquired 3.0T MRI brain scans. The brain activation MR signals were recorded and a paired voxel-wise t-test was performed. The correlations between FMRI measurement and clinical variables were calculated.
{"title":"Cortical Activation Reorganization of Cerebral Regions in Charcot– Marie–Tooth Patients: A Task-state Functional Magnetic Resonance Imaging Study","authors":"Zhifeng Wang, C. Han, C. Yuan, Yiyuan Shen, X. Geng, Chen Wang, Chao Zhang, Jiazhang Huang, Xin Ma, Hanqiu Liu, Xu Wang","doi":"10.26502/josm.511500064","DOIUrl":"https://doi.org/10.26502/josm.511500064","url":null,"abstract":"Background : Evidence of altered brain functional activation in response to different tasks has been reported in some peripheral neuropathies. The aim of this study was to investigate possible central nervous system modifications using task-state Functional Magnetic Resonance Imaging (FMRI) in Charcot–Marie–Tooth patients. Methods: A design of ankle dorsiflexion-plantarflexion and fist clutching paradigm was adopted at a frequency of 1 Hz in the FMRI portion in CMT patients and healthy controls. We acquired 3.0T MRI brain scans. The brain activation MR signals were recorded and a paired voxel-wise t-test was performed. The correlations between FMRI measurement and clinical variables were calculated.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Pelet, Jérémy Bergeron, Mireille Marquis, Etienne L Belzile
Objective: To estimate the incidence and severity of injuries sustained by a group of high-school football players and to identify risk factors associated with these injuries Design: Observational cohort study Settings: High school football programs in Quebec, Canada Participants: 707 male high-school football players were recruited and entered the study. They had to come from one of four participating high schools to be included in the study. All players completed the survey Interventions: Participants filled out a questionnaire about sociodemographic data, football experience, and life habits. They were observed throughout a football season and any injury was entered into a database by the team’s trainer “injured”
{"title":"Epidemiology of Injuries in High School Football Players: A Prospective Cohort Study","authors":"S. Pelet, Jérémy Bergeron, Mireille Marquis, Etienne L Belzile","doi":"10.26502/josm.511500065","DOIUrl":"https://doi.org/10.26502/josm.511500065","url":null,"abstract":"Objective: To estimate the incidence and severity of injuries sustained by a group of high-school football players and to identify risk factors associated with these injuries Design: Observational cohort study Settings: High school football programs in Quebec, Canada Participants: 707 male high-school football players were recruited and entered the study. They had to come from one of four participating high schools to be included in the study. All players completed the survey Interventions: Participants filled out a questionnaire about sociodemographic data, football experience, and life habits. They were observed throughout a football season and any injury was entered into a database by the team’s trainer “injured”","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cyclops lesions had been commonly reported after anterior cruciate ligament reconstructive surgeries due to many causes, mostly ACL graft tear or impingements, but the incidence of development of such lesions in non-operated knees of the native ACL, is not clearly described in the literature, this case study presents a Cyclops lesion after partial tear of anterior cruciate ligament in non-operated knee, causing loss of full knee extension with giving way.
{"title":"Cyclops Lesion of Non-Operated Knees — A Case Report","authors":"Atef Ibrahim Awad, Ibrahim el sebaei, K. Ayed","doi":"10.26502/josm.511500055","DOIUrl":"https://doi.org/10.26502/josm.511500055","url":null,"abstract":"Cyclops lesions had been commonly reported after anterior cruciate ligament reconstructive surgeries due to many causes, mostly ACL graft tear or impingements, but the incidence of development of such lesions in non-operated knees of the native ACL, is not clearly described in the literature, this case study presents a Cyclops lesion after partial tear of anterior cruciate ligament in non-operated knee, causing loss of full knee extension with giving way.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Waliul Islam, Md Tanzir-Uz-Zaman, Md. Golam Kibria, Md. Mostafijur Rahman, Md Jubair Hassan, Saddam Hossain, Md. Kutub Uddin, Mohammad Ainur Nishad Rhajib, Md Zakir Hossain, Abdullah Ibn Abul Fazal, Mohammad Anwar Hossain
{"title":"Effectiveness of Core Stabilization Exercise along with Conventional Physiotherapy on Pain, Proprioception and Disability in Patients with Chronic Low Back Pain: A Randomized Control Trial Protocol","authors":"Md. Waliul Islam, Md Tanzir-Uz-Zaman, Md. Golam Kibria, Md. Mostafijur Rahman, Md Jubair Hassan, Saddam Hossain, Md. Kutub Uddin, Mohammad Ainur Nishad Rhajib, Md Zakir Hossain, Abdullah Ibn Abul Fazal, Mohammad Anwar Hossain","doi":"10.26502/josm.511500057","DOIUrl":"https://doi.org/10.26502/josm.511500057","url":null,"abstract":"","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and Imaging Evaluation of Rotator Cuff in Male Elite Water polo Players - A Cross-Sectional Study","authors":"R. A., C. L., Ronga M","doi":"10.26502/josm.511500059","DOIUrl":"https://doi.org/10.26502/josm.511500059","url":null,"abstract":"","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Training the Industrial Athlete: Targeted Exercises to Reduce Occupational Injury Risks","authors":"Michael L. Callihan, Megan Leonard","doi":"10.26502/josm.511500051","DOIUrl":"https://doi.org/10.26502/josm.511500051","url":null,"abstract":"","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Casto Elilindia Mlay, Mubashir Alavi Jusabani, Tumaini Fedrick Minja, Elvin James Meshack, Rogers Joackim Temu
We report a case report of a 5years old girl who presented with progressive enlarged and fusion of the second and third toes of the right foot since birth which impairs shoe wear. After a clinical history and examination and radiological evaluation, the diagnosis of right foot macrodactyly was established. Following surgical excision of the macrodactyly patient showed good clinical outcome after 1year of follow-up. Numerous treatment options have been suggested without consensus, specific treatment is individualized. The primary goal for treatment is a pain-free and functional foot that can accommodate normal shoes.
{"title":"Foot Macrodactyly with Simple Syndactyly: A Case Report from Northern Tanzania","authors":"Casto Elilindia Mlay, Mubashir Alavi Jusabani, Tumaini Fedrick Minja, Elvin James Meshack, Rogers Joackim Temu","doi":"10.26502/josm.511500040","DOIUrl":"https://doi.org/10.26502/josm.511500040","url":null,"abstract":"We report a case report of a 5years old girl who presented with progressive enlarged and fusion of the second and third toes of the right foot since birth which impairs shoe wear. After a clinical history and examination and radiological evaluation, the diagnosis of right foot macrodactyly was established. Following surgical excision of the macrodactyly patient showed good clinical outcome after 1year of follow-up. Numerous treatment options have been suggested without consensus, specific treatment is individualized. The primary goal for treatment is a pain-free and functional foot that can accommodate normal shoes.","PeriodicalId":73881,"journal":{"name":"Journal of orthopaedics and sports medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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