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Phenotypic and Genotypic Characterization of Salmonella Isolated from Asymptomatic Carriers in the Suburb of Dakar 达喀尔郊区无症状携带者分离沙门氏菌的表型和基因型分析
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.346
Niang Aissatou Ahmet, Sambe Ba Bissoume, S. Abdoulaye, D. Amadou, F. Khota, Wane Abdoul Aziz, Bercion Raymond, K. Roughyatou, Sow Ahmad Iyane, G. Amy
Salmonellosis is a major public health problem, especially with the emergence of multi-resistant Salmonella. The healthy carrier, an important factor of dissemination of Salmonella in the environment ensures inter-human transmission, especially in children. In Senegal, studies on (carrying Salmonella are lacking. Thus, this work was (was conducted) to determine the (carrying rate of Salmonella), characterize phenotypically and genotypically Salmonella strains isolated from healthy carriers in Dakar. This is a prospective study of five community sites (Jeddah Thiaroye Kao, Guinaw Rail South, North Pikine, Pikine East Guinaw North Rail) between January 2013 and April 2014. Phenotypic and molecular analysis PCR detection simplex virulence genes and typing by Multi-Locus Sequence Typing were performed at the Experimental Bacteriology Unit of the Institut Pasteur in Dakar. Sixteen Salmonella of one thousand eight hundred and eighty-eight (1888) stool specimens were identified to be a carrier rate of 0.84% for a variety of serotypes (Brancaster, Chester, Give, Poona, Agona, Johannesburg, Istanbul, Enteritidis, Corvalis). If all the Salmonella strains were sensitive to beta-lactams, 25% were resistant to at least one antibiotic (nalidixic acid, trimethoprim-sulfamethoxazole and tetracycline). All isolates show all virulence genes (invA, orfL, Pipd, SpiC, Misl). Meanwhile, the SpvR virulence gene was detected in one isolate associated with Serovar enteritidis. This reflects the pathogenicity degree of Salmonella strains and therefore their ability to cause human disease. The Multi-Locus Sequence Typing (MLST) technique has revealed that phenotypically identical serotypes had no allelic variation. This suggests that these clones were widely distributed geographically and are probably outstanding in a wide range of hosts. Two new ST were found with Chester and Brancaster. Considering the characteristics of isolated Salmonella in this study and the impact of carriers on public health, monitoring of healthy carriers is needed.
沙门氏菌病是一个重大的公共卫生问题,特别是随着多重耐药沙门氏菌的出现。健康携带者是沙门氏菌在环境中传播的重要因素,保证了沙门氏菌的人际传播,尤其是在儿童中传播。在塞内加尔,缺乏关于携带沙门氏菌的研究。因此,开展这项工作是为了确定沙门氏菌的携带率,并对从达喀尔健康携带者中分离的沙门氏菌菌株进行表型和基因表型表征。这是一项2013年1月至2014年4月期间对五个社区站点(吉达Thiaroye Kao,几内亚铁路南,北Pikine, Pikine东几内亚北铁路)进行的前瞻性研究。在达喀尔巴斯德研究所实验细菌学单位进行表型和分子分析,采用PCR检测单纯毒力基因并采用多位点序列分型进行分型。1888份(1888份)粪便标本中检出16份沙门氏菌,带菌率为0.84%,不同血清型(Brancaster、Chester、Give、Poona、Agona、Johannesburg、Istanbul、Enteritidis、Corvalis)。如果所有沙门氏菌菌株都对-内酰胺敏感,则25%对至少一种抗生素(萘啶酸、甲氧苄啶-磺胺甲恶唑和四环素)耐药。所有分离株均显示所有毒力基因(invA、orfL、Pipd、SpiC、Misl)。同时,在一株肠炎血清型相关分离株中检测到SpvR毒力基因。这反映了沙门氏菌菌株的致病性程度,因此也反映了它们引起人类疾病的能力。多位点序列分型(MLST)技术显示表型相同的血清型没有等位基因变异。这表明这些克隆在地理上分布广泛,可能在广泛的宿主中表现突出。与Chester和Brancaster一起发现了两个新的ST。考虑到本研究分离沙门氏菌的特点和携带者对公共卫生的影响,需要对健康携带者进行监测。
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引用次数: 1
Analysis of Hematological Changes and Seroprevalence of Malarial Patients Caused by Plasmodium Vivax Using Statistical Tools 间日疟原虫致疟疾患者血液学变化及血清阳性率的统计分析
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.354
S. Faisal, Muhammad Taj Akbar, Abdullah, H. Shah, Asma Qudrat, Faheem Jan, Jafarpoor Ali
Malaria is a febrile illness, caused by malarial plasmodium parasite. It is the most prevalent infectious disease in the tropical and subtropical regions of the world in addition Pakistan is amongst the highly affected countries regarding infectivity rate of malaria. The main objective of the current research was to analyzed haematological changes and seroprevalence of malaria infection in patients caused by Plasmodium vivax. The study was conducted at Katlang Diagnostic Centre Mardan, Khyber Pakhtunkhwa, Pakistan. A total of 188 patients having malaria disease were enrolled, in which frequency of male patients were 122 (64.9%) while frequency of female patients was 66 (35.1%). Results indicated that there was no association between gender and BT Ring condition, because the value of chi-square (0.215) was greater than p value (0.5). Similarly, the value of chi-square (0.540) was greater than p value (0.05), which showed that there was no association between gender and B Trophozoite condition. Analysis also showed that there was close association between BT Ring and B Trophozoite condition with each other, because the value of chi-square is (0.000) which is less than p value (0.05). The present study concludes that there is a close association between BT Ring and B Trophozoite conditions.
疟疾是由疟原虫引起的发热性疾病。疟疾是世界热带和亚热带地区最普遍的传染病,此外,巴基斯坦是疟疾感染率最高的国家之一。本研究的主要目的是分析间日疟原虫感染患者的血液学变化和血清患病率。这项研究是在巴基斯坦开伯尔-普赫图赫瓦省的Katlang诊断中心进行的。总共登记了188名疟疾患者,其中男性患者为122人(64.9%),女性患者为66人(35.1%)。结果显示,性别与BT Ring状况无相关性,卡方值(0.215)大于p值(0.5)。同样,卡方值(0.540)大于p值(0.05),表明性别与B滋养体状态无相关性。分析还表明,BT环与B滋养体状态之间存在密切关联,卡方值为0.000,小于p值0.05。本研究认为,BT环与B滋养体条件密切相关。
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引用次数: 0
Risk Factors and Management Practices for Malaria Among Pregnant Women in Owerri Metropolis-A Population-Based Study 奥韦里大都市孕妇疟疾的危险因素和管理措施——一项基于人群的研究
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.355
Chiazor Somachi Obodo, Obiageli Patience Ubachukwu, C. G. Nwosu, Ifeoma Esther Aniaku
Malaria risks and management practices among women receiving antenatal care in Owerri metropolis, Imo State was investigated. A total of 342 pregnant women that had lived in the study area for at least 1 year were recruited. Ethical clearance and informed consent were sought and obtained prior to the survey. At recruitment, each participating woman was administered a questionnaire to help capture information on risk factors, clinical status and symptoms, and their ethno-management practices. Results showed that the risk factors that predisposed pregnant women to P. falciparum infection implicated presence of sewage and overgrown bushes around residence, engaging in much farming and staying outdoors at night, when compared with abstainers that had less likelihood (p<0.05). Less than 35% of the women admitted they had episodes of fever, headache, cough/catarrah, anorexia and weakness, and mostly occurred during their first trimester. Malaria management among the women were the use of spray (37.4%), drug (27.5%) and treated net (19.3%) among others, with poor compliance and adherence. High preponderant of the women responded they had treatment satisfaction due to good health care delivery (38.0%) and drug effectiveness (33.3%) at moderate treatment cost. In conclusion, whereas environmental and behavioural factors do expose pregnant women alike to malaria infection, those in their first trimester are at more risk considering the higher rate of their clinical manifestations. Therefore, awareness campaigns by healthcare workers and/or trained volunteers should be carried out more intensely to address the poor compliance to malaria management procedures in the study area.
对伊莫州奥韦里市接受产前护理的妇女中的疟疾风险和管理做法进行了调查。总共招募了342名在研究区域居住至少1年的孕妇。在调查前,我们寻求并获得了伦理许可和知情同意。在招募时,向每位参与的妇女发放了一份问卷,以帮助获取有关风险因素、临床状况和症状以及她们的种族管理做法的信息。结果表明,与不接触恶性疟原虫的孕妇相比,居住地周围有污水和杂草丛生的灌木丛、从事大量耕作和夜间在户外活动是孕妇感染恶性疟原虫的易感因素(p<0.05)。不到35%的女性承认她们有发热、头痛、咳嗽/卡他拉、厌食和虚弱的症状,而且大多发生在妊娠的前三个月。妇女的疟疾管理是使用喷雾(37.4%)、药物(27.5%)和处理过的蚊帐(19.3%)等,依从性和依从性较差。绝大多数妇女回答说,由于良好的医疗服务(38.0%)和药物有效性(33.3%),在中等治疗费用下,她们对治疗感到满意。总之,虽然环境和行为因素确实使孕妇同样暴露于疟疾感染,但考虑到其临床表现的较高比率,孕早期妇女面临的风险更大。因此,保健工作者和/或训练有素的志愿者应更积极地开展提高认识运动,以解决研究地区对疟疾管理程序遵守不力的问题。
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引用次数: 1
Favipiravir: Promising Therapy for COVID-19 Favipiravir:有望治疗COVID-19
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.356
Amitabha Das
COVID 19 is become one of the most threatened pandemics in recent time and spreading rapidly. Favipiravir, an antiviral drug, has shown promising but yet unproven effect against COVID-19 infection. Drug Controller General of India (DCGI) has recently approved Favipiravir for treating moderate to severe COVID-19 infected patients. Favipiravir, a broad-spectrum antiviral drug that interferes with the viral replication and emerging as promising therapeutic potential as indicated by initial clinical studies. In this literature review author tries to summaries an overview of Favipiravir as a promising therapy for COVID-19 disease.
COVID - 19已成为近年来最受威胁的流行病之一,并迅速蔓延。抗病毒药物法匹拉韦(Favipiravir)对COVID-19感染显示出有希望但尚未证实的效果。印度药品监督管理局(DCGI)最近批准了Favipiravir用于治疗中至重度COVID-19感染患者。Favipiravir是一种广谱抗病毒药物,可干扰病毒复制,初步临床研究表明其具有良好的治疗潜力。在这篇文献综述中,作者试图总结Favipiravir作为一种有前景的COVID-19疾病治疗方法的概述。
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引用次数: 0
Factors Affecting Implementation of Laboratory Quality Management System inAddis Ababa Public Health Laboratories, Addis Ababa, Ethiopia 影响亚的斯亚贝巴公共卫生实验室质量管理体系实施的因素
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.19.8.343
Abay Sisay, Ashebir Gurmessa, Wondimeneh Liknew
Background: Laboratory quality management system is one of the most important initiative change taken place in the field of the medical laboratory as a comprehensive and transformational strategy to improve the quality of service to respond the needs and expectations of the society in Ethiopia since 2009. Objective: This study aimed to assess factors affecting laboratory quality management system implementation among Addis Ababa health laboratories, Ethiopia. Materials and Methods: A cross-sectional study design approach was used from September 2017 to February 2018 using both quantitative and quantitative data collection approach. Data were entered, cleaned using EPI-Data 3.1 and exported to SPSS version.20 software for analysis. Results: Nine variables were found considerably associated with LQMS implementation (p<0.05) where method validation and verification, root cause analysis, laboratory equipment maintenance related issues, external quality assessment, professional competency, measurement uncertainty analysis, evaluation, and audit and trained staff turnover. Conclusion: The overall findings illustrate that there is a need for facility management should set a specified budget for laboratory quality management implementation and should into consideration those factors while laboratory quality management system implementation.
背景:自2009年以来,实验室质量管理体系是医学实验室领域发生的最重要的主动变化之一,是一项全面的转型战略,旨在提高服务质量,以响应埃塞俄比亚社会的需求和期望。目的:探讨埃塞俄比亚亚的斯亚贝巴卫生实验室质量管理体系实施的影响因素。材料和方法:2017年9月至2018年2月采用横断面研究设计方法,采用定量和定量数据收集方法。输入数据,使用EPI-Data 3.1进行清理,导出到SPSS版本。20 .分析软件。结果:方法验证和验证、根本原因分析、实验室设备维护相关问题、外部质量评价、专业能力、测量不确定度分析、评价和审核、培训人员离职等9个变量与LQMS实施存在显著相关性(p<0.05)。结论:研究结果表明,实验室质量管理体系的实施需要设施管理部门为实验室质量管理体系的实施制定明确的预算,并应考虑这些因素。
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引用次数: 0
Infection Prevention and Control in North-East Nigeria: An Assessment ofHand Hygiene in Health Care Facilities in Protracted Crisis EnvironmentFebruary 2019 尼日利亚东北部感染预防和控制:长期危机环境下卫生保健机构手部卫生评估
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.19.8.345
Daggash Batula Bishara, Sotimehin Oladipo, Mshelia Lawi, N. ini, Owili Collins, Onuekwe E.Chima
Introduction: Hand hygiene is the single most effective action to prevent the spread of Healthcare-Associated Infections and Antimicrobial Resistance among health care workers and patients. The lack of effective hand hygiene and materials for hand hygiene is a major problem for patient safety in health care facilities. We conducted this survey in February 2019 to assess the situation of hand hygiene in health care facilities in Borno State, the epicenter of insurgency in North-East Nigeria. Method: An interviewer-administered questionnaire was used to assess the situation of hand hygiene from 103 health care facilities selected from across Borno State. The questionnaire used was adopted from the WHO Hand Hygiene Self-Assessment Framework at the facility level. It had five sections (System change, training, and education, evaluation and feedback, reminders in the workplace, institutional safety climate for hand hygiene) and 27 indicators framed as questions with “yes” or “no” response. Each health facility’s response was scored, calculated and expressed as a proportion of the total score of 500. Based on the score obtained, each facility was assigned to one of four categories ranging from inadequate, basic, intermediate to advanced hand hygiene level. Results: One hundred and three health facilities were involved in the assessment. Eighty-nine (86.4%) were public, government-owned health care facilities. The highest participation was from the central zone of the state with 43 (41.7%) while the northern zone of the state recorded the lowest participation 25 (24.3%). Central zone participation was 43 (41.7%). Seventy-eight (75.8%) of the total health facilities had inadequate hand hygiene levels, 21 (20.4%) had basic hand hygiene levels, 4 (3.8%) had intermediate hand hygiene level and none (0%) had advanced hand hygiene level. Summary statistics (mean ± SD, Median: IQR) for the five sections showed the following; System change (availability of soap, running water, single-use hand towels)-19 ± 21, 15: 30; education and training (on hand hygiene)-10.3 ± 15.0, 0: 3.0; evaluation and feedback (assess availability of water, soap, towel, and hand hygiene compliance)-13.0 ± 17.4, 0: 25; reminders in the workplace (posters and leaflets)-19.2 ± 21.0, 20: 15 and institutional safety climate for hand hygiene (functional hand hygiene teams, patient involvement in hand hygiene and regular communication)-14 ± 25.0,0:20. The overall scores summary statistics were 75.6 ± 78.5, 55: 125. Conclusion: This assessment revealed gross inadequacies in hand hygiene practice and hand hygiene promotion in government-owned Primary Health Care Facilities in Borno state. There is a need to scale up efforts to improve hand hygiene practices and hand hygiene promotion activities in the State to enhance the quality of care and minimize the incidence of Healthcare-Associated Infections.
手部卫生是预防卫生保健相关感染和抗菌素耐药性在卫生保健工作者和患者中传播的唯一最有效的行动。缺乏有效的手部卫生和手部卫生材料是卫生保健设施中患者安全的一个主要问题。我们于2019年2月进行了这项调查,以评估尼日利亚东北部叛乱中心博尔诺州卫生保健机构的手部卫生状况。方法:采用访谈问卷对博尔诺州103家卫生保健机构的手卫生状况进行评估。所使用的问卷采用了世卫组织在设施一级的手卫生自我评估框架。它有五个部分(系统变化、培训和教育、评估和反馈、工作场所提醒、机构安全环境手部卫生)和27个指标,以“是”或“否”回答问题。对每个卫生设施的答复进行评分、计算并表示为总分500的比例。根据获得的分数,每家机构被划分为手卫生水平不足、基本、中级到高级四个类别之一。结果:103家卫生机构参与了评价。89家(86.4%)是公立、政府所有的卫生保健机构。参与人数最多的是中部地区,有43人(41.7%),最低的是北部地区,只有25人(24.3%)。中心区参与率为43例(41.7%)。78家卫生机构(75.8%)手卫生水平不高,21家(20.4%)为基本手卫生水平,4家(3.8%)为中等手卫生水平,0家(0%)为高级手卫生水平。五组的汇总统计数据(mean±SD, Median: IQR)如下:系统变更(肥皂、自来水、一次性毛巾的供应情况)-19±21,15:30;教育和培训(手卫生)-10.3±15.0,0:3.0;评估和反馈(评估水、肥皂、毛巾的可用性和手卫生依从性)-13.0±17.4,0,25;工作场所提醒(海报和传单)-19.2±21.0,20:15和机构手卫生安全氛围(手卫生功能团队,患者参与手卫生和定期沟通)-14±25.0,0:20。综合统计总分为75.6±78.5,55:125。结论:该评估揭示了博尔诺州政府所有的初级卫生保健机构在手卫生实践和手卫生推广方面的严重不足。有必要加大努力,改善该州的手卫生习惯和手卫生宣传活动,以提高护理质量,并尽量减少卫生保健相关感染的发生率。
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引用次数: 0
Assessment of Standard Precautions Practices Among Health Care Workers in a Rural Area of South-South Nigeria 尼日利亚南南农村地区卫生保健工作者标准预防措施评估
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.351
F. Ehimen, Emmanuel Friday Osagiedeo, Ofili An, E. A. Ozomata, P. Okoukpon, Airefetalor Ia
Health care workers are continuously at risk of blood borne infections because of their exposure to blood and body fluids during care of patients and these exposures are potentially infectious. Hence, regular adherence to standard precautions is widely advocated by World Health Organization and Centres of Disease Control as a primary strategy for controlling occupational exposure to blood and body fluids. Objectives: To evaluate knowledge, practices of HCW concerning blood- borne pathogens and adherence to standard precautions Methods: Rural based cross sectional study with quantitative and qualitative component was conducted among two hundred and thirteen health care workers in Ekpoma, Edo State. Results: Of all the Health care workers studied, only less than one third of respondents had good knowledge and practice of standard precautions. Conclusion: The knowledge and practice of standard precautions was found to be generally poor. Hence, all health care workers should be trained on the principles of infection control and exposure prevention.
卫生保健工作者由于在护理病人期间接触血液和体液而持续面临血源性感染的风险,这些接触具有潜在传染性。因此,世界卫生组织和疾病控制中心广泛提倡定期遵守标准预防措施,作为控制职业接触血液和体液的主要战略。目的:评价血源性病原体卫生保健的知识、实践和对标准预防措施的依从性。方法:对江户州埃克波马市213名卫生保健工作者进行了定量和定性的农村横断面研究。结果:在所研究的所有卫生保健工作者中,只有不到三分之一的受访者对标准预防措施有良好的了解和实践。结论:医院对标准预防措施的认识和实践普遍较差。因此,所有卫生保健工作者都应接受有关感染控制和接触预防原则的培训。
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引用次数: 3
Knowledge and Screening on Sexually Transmitted Diseases Among Adults in Maiduguri Metropolis of Borno State Northern-Eastern, Nigeria 尼日利亚东北部博尔诺州迈杜古里市成年人对性传播疾病的知识和筛查
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.357
S. S. Buba
This study assessed the knowledge of adult on sexually transmitted diseases in Maiduguri metropolis of Borno State North-Eastern, Nigeria. In order to achieve this objective, one research objectives and one research question was formulated and three null hypotheses were tested. The theoretical frame work used for this study was theory of Health Belief Model developed by Stretcher and Rosentock. The Health Belief Model (HBM) is a theoretical framework used to understand health behaviours and possible reason for non-compliance with recommended health action. Related literature was reviewed under the following sub-headings: Concept of sexually transmitted infections, epidemiology/pathogenesis of sexually transmitted infections and Types of sexually transmitted infections. Survey research design was used for this study. The populations for this study was made up of ten thousand and-ten (10,010), INEC, 2019, and five hundred (500) respondents were sampled for the study using simple random sampling. Data were collected using questionnaire on knowledge and screening for sexually transmitted diseases among adult in Maiduguri metropolis (KSSTD). Five hundred respondents were sampled for this study and analyzed using descriptive statistics of frequency count and percentages to describe the demographic characteristics of the respondents and to answer research questions. While, inferential statistics of Chi-square test was used to test the research hypotheses at 0.05 alpha level of significant. The result of the finding revealed that adult in Maiduguri metropolis had good knowledge of sexually transmitted diseases. Also, the result of the findings revealed statistically that knowledge of sexually transmitted diseases in Maiduguri metropolis among adult of different educational background did not differ significantly (p˃0.05). While, knowledge of sexually transmitted diseases between male and female in Maiduguri metropolis differed significantly (p˂0.05), and knowledge of sexually transmitted diseases in Maiduguri metropolis among adult of different ethnic background did not differ significantly (p˃0.05). It was concluded that adult in Maiduguri metropolis have the knowledge of sexually transmitted diseases. For example some respondents believed that sexually transmitted infections is a blood borne diseases, furthermore, some respondents believed that viruses and bacteria are the causative agent of most sexually transmitted infection, while some respondents believed that sexually transmitted infections can be transmitted during sexual intercourse, from mother to her unborn child through umbilical cord or from mother to her child during child birth. It was also found some that respondents strongly agreed that HBV, HPV and HIV were commonly caused by viral infection, while syphilis, gonorrhoea, trachoma and chlamydia are caused by bacteria. And majority of the respondents in Maiduguri metropolis believed that going for screening regularly and before marriage ca
本研究评估了尼日利亚东北部博尔诺州迈杜古里市成人对性传播疾病的知识。为了实现这一目标,制定了一个研究目标和一个研究问题,并检验了三个零假设。本研究采用的理论框架是Stretcher和Rosentock的健康信念模型理论。健康信念模型(HBM)是一个理论框架,用于理解健康行为和不遵守建议的健康行动的可能原因。本文对性传播感染的概念、性传播感染的流行病学/发病机制和性传播感染的类型进行了综述。本研究采用调查研究设计。本研究的人口由2019年INEC的10,010人组成,并采用简单随机抽样的方法抽取了500名受访者进行研究。采用迈杜古里市区成人性传播疾病知识和筛查调查表收集数据。本研究抽样了500名受访者,并使用频率计数和百分比的描述性统计来分析,以描述受访者的人口特征并回答研究问题。采用卡方检验的推理统计方法,在0.05的α显著水平下检验研究假设。调查结果表明,迈杜古里大都市的成年人对性传播疾病有良好的了解。调查结果显示,迈杜古里城区不同学历成人对性传播疾病知识知晓程度差异无统计学意义(p > 0.05)。迈杜古里城区男女对性传播疾病的知识知晓程度差异有统计学意义(p小于0.05),不同民族成人对性传播疾病的知识知晓程度差异无统计学意义(p < 0.05)。结果表明,迈杜古里市区的成年人对性传播疾病有一定的了解。例如,一些答复者认为性传播感染是一种血液传播疾病,此外,一些答复者认为病毒和细菌是大多数性传播感染的病原体,而一些答复者认为性传播感染可以在性交中传播,也可以通过脐带从母亲传播给未出生的孩子,也可以在分娩时从母亲传播给孩子。还发现,部分受访者强烈认同HBV、HPV和HIV是常见的病毒感染原因,而梅毒、淋病、沙眼和衣原体是细菌感染原因。迈杜古里大都市里的大多数答复者认为,定期和婚前进行筛查可以防止乙型肝炎病毒、人乳头瘤病毒和艾滋病毒/艾滋病等性传播感染的传播。委员会建议政府开展提高认识讲习班和公众启蒙运动,教育广大青年认识到性传播疾病和定期检查性传播疾病的重要性。需要组织良好的卫生教育运动和媒体(电视、广播和互联网),以提高公众对性传播感染的认识和了解。应该开展大规模的教育运动,让包括保健工作者和社区成员在内的社会所有利益攸关方参与进来,使社会在性传播疾病问题上更加宽容。
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引用次数: 0
Pasteurellosis Status in Ethiopia: A Comprehensive Review 埃塞俄比亚巴氏杆菌病现状:全面审查
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.20.8.348
Kula Jilo, T. Belachew, Worku Birhanu, D. Habte, Waktole Yadeta, A. Giro
Ethiopia has the largest national livestock populations in Africa. However, the productivity is one of the marginal due to a number of technical and non-technical factors. Infectious diseases like pasteurellosis are highly affecting livestock industry in the country. Pasteurellosis is a multifactorial disease caused by numerous etiologic agents. Mannheimia haemolytica, Bibersteinia trehalosi and Pasteurella multocida cause pasteurellosis in animals and humans. Pasteurella are commensal organisms of healthy animals which can be trigger with stress factors to cause fatal disease in farm animals. Infective agents acquired by inhalation of infected droplets or close contacts among susceptible animals. Pasteurellosis is responsible for huge mortality in feedlot animals worldwide. Haemorrhagic septicemia is an acute and characterized by sudden onset of fever, profuse salivation, severe dyspnea and death in about 24 hours whereas shipping fever causes severe broncho-pneumonia and pleurisy. The diagnosis of the disease is based on the clinical signs, gross pathological lesions, isolation of the pathogens and molecular characterization. Pasteurellosis is complex multifactorial disease difficult to control however, good management, chemotherapy, chemoprophylaxis and early immunization are control and preventive measures. In Ethiopia pasteurellosis is an endemic disease posing a serious threat to the animal productions. However, data on epidemiology, diagnosis, prevention and control is scarce. Therefore, a routine national wide survey encompassing multiple hosts and wider area should be undertaken to figure out prevalence and identify circulating serotypes in different agro ecology to design and implement appropriate interventions.
埃塞俄比亚是非洲牲畜数量最多的国家。然而,由于许多技术和非技术因素的影响,生产率是一个边际。巴氏杆菌病等传染病严重影响着该国的畜牧业。巴氏杆菌病是一种由多种病原引起的多因素疾病。溶血性曼海姆氏菌、海卤毕氏菌和多杀性巴氏菌引起动物和人类的巴氏菌病。巴氏杆菌是健康动物的共生生物,可与应激因素一起引发农场动物的致命疾病。通过吸入受感染飞沫或易感动物之间的密切接触而获得的传染原。巴氏杆菌病是造成全世界饲养场动物大量死亡的原因。出血性败血症是一种急性败血症,其特征是突然发热、大量流涎、严重呼吸困难和在约24小时内死亡,而船热则引起严重的支气管肺炎和胸膜炎。该病的诊断是基于临床症状、大体病理病变、病原体的分离和分子特征。巴氏杆菌病是一种复杂的多因素疾病,难以控制,但良好的管理、化疗、化学预防和早期免疫是控制和预防措施。在埃塞俄比亚,巴氏杆菌病是一种地方性疾病,对动物生产构成严重威胁。然而,关于流行病学、诊断、预防和控制的数据很少。因此,应在全国范围内开展包括多个宿主和更广泛地区的常规调查,以查明不同农业生态中的流行情况并确定循环血清型,从而设计和实施适当的干预措施。
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引用次数: 1
The Dissimilarity of Attack Rate (AR) of SARS-CoV-2 Virus and Infection Fatality Risk (IFR) Across Different Divisions of Bangladesh 孟加拉国不同地区SARS-CoV-2病毒的发病率(AR)和感染死亡风险(IFR)的差异
Pub Date : 2020-01-01 DOI: 10.35248/2329-891X.2020.8.352
P. Ghosh
Bangladesh has been identified the novel coronavirus disease 2019 (COVID-19) first cases by the Reverse Transcription Polymerase Chain Reaction (RT-PCR) test in March, 2020. As of 15 May 2020, Bangladesh has reported 20,065 confirmed cases. We aimed to assess the variation in the attack rate (AR), sample test, positivity rate and infection fatality risk (IFR) related to COVID-19 patients in these divisions. The number of testing COVID-19 samples by RT-PCR per 100000 populations was the highest in Dhaka (271) and lowest in Barishal (33). Dhaka is the most overcrowded division (1751 per square kilometers). We found that the highest sample tested (271 per 100000), higher attack rate (AR) (386 per million) and positivity rate (14.2%) in Dhaka division compared to those of the other 7 divisions. Rajshahi is the lowest densely-populated division, was the most infected fatality risk (IFR) (11%) compared to the other 7 divisions. This study suggests that more sample testing would be necessary to explore the burden of COVID-19 and mortality rate in the adult population and rural communities.
孟加拉国于2020年3月通过逆转录聚合酶链反应(RT-PCR)检测确定了2019年新型冠状病毒病(COVID-19)首例病例。截至2020年5月15日,孟加拉国报告了20,065例确诊病例。我们的目的是评估这些地区与COVID-19患者相关的发病率(AR)、样本检测、阳性率和感染死亡风险(IFR)的变化。每10万人中通过RT-PCR检测COVID-19样本的数量在达卡最高(271),在巴里沙尔最低(33)。达卡是最拥挤的地区(每平方公里1751人)。我们发现,与其他7个地区相比,达卡地区的检测样本最高(271 / 10万),发病率(386 / 100万)和阳性率(14.2%)较高。拉杰沙希是人口密度最低的区,与其他7个区相比,感染死亡风险最高(11%)。这项研究表明,需要更多的样本检测来探索成人和农村社区的COVID-19负担和死亡率。
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引用次数: 0
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Journal of tropical diseases & public health
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