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RECEPTIVE STATUS OF THE ENDOMETRIUM IN PATIENTS OF REPRODUCTIVE AGE WITH SEROUS AND MUCINOUS OVARIAN CYSTEDNOMA BEFORE AND AFTER UNILATERAL ADNEXECTOMY 单侧附件切除术前后育龄卵巢浆液性和黏液性囊肿瘤患者子宫内膜的接受状态
Pub Date : 2023-06-28 DOI: 10.17816/morph.430317
L. Mikhaleva, A. Solomatina, A. Gashimova, Biryukov Andrey Evgenievich, Natalia Alexandrovna Gracheva, S. A. Mikhalev, Elizaveta Alexandrovna Tumasyan, Parvana Jabirovna Ismaiilova, V. Banin
Background. Currently, there is an increase in benign ovarian tumors, which, according to the results of numerous studies, negatively affect the reproductive health of women. Patients seeking to preserve their reproductive function prefer organ-preserving surgical interventions, however, in clinical practice, adnexectomy is often necessary due to the absence of intact ovarian tissue. Aim. Analysis of the morphofunctional state of the endometrium and its receptivity in patients with serous and mucinous ovarian cystadenomas before and after surgical treatment. Methods. The prospective study included patients of reproductive age with benign epithelial tumors: serous/mucinous cystadenomas who had not received hormonal drugs for six months prior to surgical treatment. 32 patients with serous cystadenoma were included in group I, 30 patients with mucinous cystadenoma in group II. Before and 6-12 months after unilateral salpingo-oophorectomy, a pipel biopsy of the endometrium was performed during the "implantation window". The qualitative and quantitative parameters of pinopodia were studied, the expression of estrogen (ER) and progesterone (PR) receptors in the glands and stroma of the endometrium were studied. Results. In the postoperative period, an increase in the number of mature pinopodia, a growing in the expression of ER in the stroma and PR in the stroma and glands was revealed. When analyzing the data in patients with mucinous cystadenoma After surgical treatment, in patients with mucinous cystadenoma, in comparison with the data of the serous patients in the glandular component of the endometrium, the expression of both ER and PR was lower, and the expression of PR in the stromal component was also lower, a growing in the number of developing pinopodia was recorded. Conclusion. The results of our study showed that benign ovarian tumors is accompanied by disorders of the morphofunctional state and receptivity of the endometrium.
背景。目前,良性卵巢肿瘤有所增加,许多研究结果表明,良性卵巢肿瘤对妇女的生殖健康产生负面影响。寻求保留生殖功能的患者更倾向于保留器官的手术干预,然而,在临床实践中,由于缺乏完整的卵巢组织,附件切除术往往是必要的。的目标。浆液性和黏液性卵巢囊腺瘤手术前后子宫内膜形态功能状态及容受性分析。方法。该前瞻性研究包括育龄良性上皮肿瘤患者:浆液/粘液囊腺瘤,手术治疗前6个月未接受激素药物治疗。其中浆液性囊腺瘤32例为ⅰ组,粘液性囊腺瘤30例为ⅱ组。在单侧输卵管卵巢切除术前和术后6-12个月,在“着床窗口”期间对子宫内膜进行输卵管活检。研究了足部的定性和定量参数,研究了子宫内膜腺体和间质中雌激素(ER)和孕激素(PR)受体的表达。结果。术后成熟足数量增多,间质ER表达增多,间质及腺体PR表达增多。在分析手术治疗后粘液囊腺瘤患者的数据时,在粘液囊腺瘤患者中,与浆液性患者相比,子宫内膜腺成分中ER和PR的表达均较低,基质成分中PR的表达也较低,记录了发生足突的数量增加。结论。我们的研究结果表明,卵巢良性肿瘤伴随着子宫内膜形态功能状态和容受性的紊乱。
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引用次数: 0
Syntagmatic paradigms: learning correspondence from contiguity 组合范式:从邻接中学习对应
Pub Date : 2023-06-19 DOI: 10.1007/s11525-023-09411-w
Amy Smolek, Vsevolod Kapatsinski
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引用次数: 0
Prognostic significance of the immunohistochemical status of the endometrium as markers of therapy for endometrial hyperplasia 子宫内膜免疫组化状态作为子宫内膜增生治疗标记物的预后意义
Pub Date : 2023-06-07 DOI: 10.17816/morph.364510
K. Shcherbatyuk, L. Mikhaleva, L. Kappusheva, Georgiy Golukhov, Dina Gutorova, Anstasiya Ovchinnikova, B. Baisova, V. Breusenko
BACKGROUND: in patients of the reproductive period with endometrial hyperplasia without atypia (EH), the issue of choosing hormonal treatment and prognosis of response to it remains relevant. AIM:to increase the effectiveness of hormonal therapy for EH in patients of reproductive age with abnormal uterine bleeding (AUB), taking into account data on receptivity and proliferative activity of the endometrium. METHODS:179 patients of the reproductive period with AUB and EH were examined. After removal of the endometrial tissue, hormonal therapy was performed for 6 months: 101 patients - dydrogesterone 20 mg/day, 78 patients - norethisterone acetate 10 mg/day. Expression of ER, PR, Ki67 in endometrial tissue was determined by immunohistochemistry (IHC) at baseline and 3 months after the end of treatment. The comparison group consisted of 18 women without gynecological pathology. RESULTS:Before treatment, the expression of ER, PR in both compartments, Ki67 in the glands is lower (p0.05) in patients with HE compared with the control group. Remission was achieved in 77 (76.24%) (dydrogesterone) and 62 (79.49%) (norethisterone acetate). Initially, ER in the glands and stroma of GE is lower (p0.05) than the comparison group; in the group of resistant patients - lower (p0.05) responders to treatment. PR in the group of resistant patients is lower (p0.05) than the comparison group and those who have achieved remission. Ki67 in the glands in the group of those who responded to treatment is lower (p0.05) than the comparison group, in the stromal - lower (p0.05) of resistant patients. After treatment in both compartments ER and PR in the group of resistant patients is lower (p0.05) than in the comparison group and those who responded to treatment. A logistic regression equation was obtained with a set of predictors: ER (glands) + PR (glands and stroma) + Ki-67 (stroma) with a potential response to therapy of 93%. CONCLUSION: it is promising to use the specified predictive model. The effectiveness of therapy will be observed in 93% of cases.
背景:在育龄期无异型性子宫内膜增生(EH)患者中,激素治疗的选择和预后反应仍然是一个重要的问题。目的:考虑子宫内膜容受性和增殖活性的数据,提高育龄伴有子宫异常出血(AUB)的EH患者激素治疗的有效性。方法:对179例育龄期合并AUB和EH的患者进行检查。切除子宫内膜组织后,进行激素治疗6个月:101例患者使用地屈孕酮20mg /天,78例患者使用醋酸去甲睾酮10mg /天。采用免疫组化(IHC)方法检测各组患者在治疗前和治疗结束后3个月子宫内膜ER、PR、Ki67的表达。对照组为18例无妇科病理的妇女。结果:治疗前,HE组ER、两房室PR、腺体Ki67的表达均低于对照组(p0.05)。地屈孕酮77例(76.24%)缓解,醋酸去甲睾酮62例(79.49%)缓解。初期,GE组腺体和间质ER低于对照组(p0.05);耐药组对治疗的反应较低(p0.05)。耐药组的PR低于对照组和缓解组(p0.05)。治疗有反应组的腺体Ki67低于对照组(p0.05),耐药组的间质Ki67低于对照组(p0.05)。两室治疗后,耐药组ER和PR均低于对照组和治疗有效组(p0.05)。通过一组预测因子得到logistic回归方程:ER(腺体)+ PR(腺体和间质)+ Ki-67(间质),治疗的潜在反应为93%。结论:该预测模型具有较好的应用前景。在93%的病例中观察到治疗的有效性。
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引用次数: 0
A Study on the Eogiseol in the Japanese Korean Language Education Society and Park Seung-bin(1931), the Theory of Conjugation of Korean Verbs and Adjectives 日本韩国语教育社对母羊脂的研究及朴承彬(1931)的《韩国语动词和形容词的共轭理论》
Pub Date : 2023-05-31 DOI: 10.51157/kmor.2023.25.1.33
Jusang Kim
This paper compared the Park Seung-bin(1931) and the Eogiseol, which are currently used in the Korean language education society in Japan. For this purpose, we first investigated what is the Eogiseol and examined the formation process of it. In Eogiseol, Eogi is a combination of basic forms such as ‘먹’, ‘작’ and ‘-으-’ or ‘-아/어-’ which are thematic vowel, And three Eogie types are depending on the types of endings, and Eogies change their forms but endings are fixed. This shows the opposite perspective from the general conjugation theory that the stem does not change, but the ending changes. The formation process of Eogiseol generally shows the flow of ‘前間恭作→河野六郞→菅野裕臣→浜之上幸’, and it can be seen that the results obtained from the study of medieval Korean are applied to modern Korean. The similarities between the Eogiseol and Park Seung-bin(1931) are discussed in terms of similarities of phonetic realization of ‘먹으’+‘니’ of the Second-Eogi-type and ‘머그’+‘니’ of Park Seung-bin(1931), ‘먹어’+‘서’ of the Third-Eogi-type and ‘머거’+‘서’ of Park Seung-bin(1931), but if we look a little deeper, we can know that the way of spelling is different like ‘먹’ and ‘머그’, the basic type setting is different as ‘먹’ and ‘머그’, and the area of the stem is also different because it is up to ‘먹’ while ‘머’ is different. In addition, supporters of Eogisol argue advantages of the use of Eogisol in the Japanese Korean language education society in that Eogisol does not give learners much concern and can derive the conjugation type quickly and accurately in that it memorizes the form of Eogi according to the type of endings, but the theory of conjugation based on the premise that ‘-으-’ and ‘-아/어-’ belong to the stem can lead to a shift away from the essence of the conjugation of Korean verbs and adjectives that the stem does not change and the ending changes, so deeper consideration of the consistency of the theory is needed.
本文比较了目前日本韩国语教育界使用的朴承彬(1931年)和Eogiseol。为此,我们首先研究了什么是Eogiseol,并考察了它的形成过程。在Eogiseol中,Eogi是一些基本形式的组合,如“”、“”和“- -”或“- / -”,这些都是主音元音。三种Eogi类型取决于结尾的类型,Eogi可以改变形式,但结尾是固定的。这显示了与一般共轭理论相反的观点,即词干不变,但词尾变化。Eogiseol通常显示了流的形成过程的前間恭作→河野六郞→菅野裕臣→浜之上幸”,它的结果可以看出,研究中世纪朝鲜被应用到现代韩国人。Eogiseol之间的相似之处和公园Seung-bin(1931)讨论了相似的语音实现“먹으”+“니”Second-Eogi-type和“머그”+“니”公园Seung-bin(1931),“먹어”+“서”Third-Eogi-type和“머거”+“서”公园Seung-bin(1931),但是如果我们看起来有点深,我们可以知道拼写的不同“먹”和“머그”,基本类型设置不同的“먹”和“머그”,而词干的面积也不同,因为它一直到“聚合”,而“聚合”是不同的。此外,在日本韩国语教育社中,Eogisol的支持者认为使用Eogisol的优势在于,Eogisol不会给学习者带来太多的关注,而且根据词尾的类型来记忆Eogisol的形式,可以快速准确地推导出词形类型。但共轭理论基于这样一个前提:“(으)”和“-아/어”属于会导致转变源自韩国动词和形容词的词形变化的本质,阀杆不会改变,结局改变,因此需要深入考虑的一致性理论。
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引用次数: 0
A Study on Verification Methods of Vocabulary Grade 词汇等级验证方法研究
Pub Date : 2023-05-31 DOI: 10.51157/kmor.2023.25.1.57
Soyoung Choi, Taejoon Park, Jinho Park
In this study, a new method was designed and verified to verify the validity of the 'vocabulary grading list', which selected and graded educational vocabulary to support systematic vocabulary teaching and learning in school education. As a verification method, the following two-way method was devised. First, as a way to expand language life beyond school education, it is a way to verify validity by checking whether the vocabulary grade to be verified is a level that appropriately reflects general language life in the wider world than school education. To implement this plan, a hierarchy of vocabulary extracted from a large-scale corpus, which is a new basic data, was set up and a method of comparative analysis with the grade of this study was designed. Second, it is a convergent method to verify the validity by focusing more on the educational purpose of the vocabulary grade and checking whether it is a level that can explain specific teaching-learning aspects of school education. To implement this plan, a method was designed to reveal the degree of linkage with textbook text readability levels of various subjects through correlation analysis and regression analysis. As a result of the verification, the vocabulary grade of this study was quite consistent with the lexical hierarchy extracted based on the large-scale corpus and the level of readability evaluation of textbook texts, but showed a tendency to show a high degree of concordance, especially in low-level easy vocabulary, and the verification result index was poor. If not, they showed mutual similarity. Through this, it was confirmed that the verification method of this study was partially effective, and it could be said that it was a useful verification result in that it consistently informs the direction of supplementation of the vocabulary ranking list. The vocabulary grade verification method explored in this study is meaningful in that it improved the empirical quality of vocabulary grade setting and grade verification.
本研究设计并验证了一种新的方法来验证“词汇分级表”的有效性,该分级表对教育词汇进行筛选和分级,以支持学校教育中系统的词汇教学。作为验证方法,我们设计了如下的双向方法:首先,作为一种扩展学校教育之外的语言生活的方式,通过检查待验证的词汇等级是否在比学校教育更广阔的世界中恰当地反映了一般语言生活的水平来验证有效性。为了实现这一计划,从大规模语料库中提取新的基础数据,建立了词汇层次结构,并设计了与本研究等级对比分析的方法。其次,通过更加关注词汇等级的教育目的,检查词汇等级是否能够解释学校教育的具体教与学方面的水平来验证有效性,是一种趋同的方法。为了实现这一计划,设计了一种方法,通过相关分析和回归分析来揭示各学科与教科书文本可读性水平的关联程度。经验证,本研究的词汇等级与基于大规模语料库和教科书文本可读性评价水平提取的词汇层次相当一致,但呈现出高度一致的趋势,特别是在低层次易读词汇上,验证结果指标较差。如果不是,它们表现出了相互的相似性。通过这一点,证实了本研究的验证方法是部分有效的,可以说这是一个有用的验证结果,它一致地告知了词汇排名表的补充方向。本研究探索的词汇等级验证方法对于提高词汇等级设置和等级验证的经验质量具有重要意义。
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引用次数: 0
On the Types and Properties of Term Abbreviations from the Perspective of Word Formation-focused on Term Abbreviations in Urimalsaem 从构词法的角度看缩略语的类型和性质——以乌里马拉语中的缩略语为例
Pub Date : 2023-05-31 DOI: 10.51157/kmor.2023.25.1.1
Hyung-yong Choi
This paper aims at revealing the types and properties of term abbreviations in Urimalsaem. Until now, abbreviations have been discussed only in the basic types such as AC, AD, BC, and BD. However, even when targeting term abbreviations for Urimalsaem, the types are not so simple. In this respect, in order to categorize 794 term abbreviations of Urimalsaem, in addition to the ‘basic type’, ‘extended type’ and ‘applied type’ were assumed. In addition, the ‘complex type’ which is combined with the basic type and the extended type was considered as a separate type, and those that did not belong to any type were grouped into ‘other type’. Through this classification, except for ‘other type’, they were subdivided into 11 extended types, 14 applied types, and 1 complex types in addition to 4 basic types. This results clearly show that the term abbreviation types are very complicated themselves. These abbreviation types have a very high sum of the proportions of the extended, applied, and complex types, although the proportion of the overall basic types is over half at 53.4%. In the case of the AD type, the ratio of the extended type (15.74%) is more than twice as high as that of the basic type (16.30%). On the other hand, compared to the ratio of AC and AD types, BC and BD types are not very productive in abbreviation methods because the sum is only 5.66% of them. When it comes to the abbreviation type, it can also be seen that the number of syllables plays a very important role in the formation of abbreviations. On the other hand, as the structural characteristics of the abbreviation, AC and AD types with the highest type frequency and item frequency were mentioned. The relationship between acronyms for AC type and blended words for AD type was also noted. In addition, among the term abbreviations, some elements appear repeatedly and continuously as former or latter position. Some of them are affixes, but others are not. Therefore, they can be separately called ‘abbreviators’. It is worth noting that these abbreviators make us predict the type of term abbreviations not just in current but also in future.
本文旨在揭示乌里马拉语中缩略语的类型和特点。到目前为止,我们只讨论了AC、AD、BC、BD等基本类型的缩略语,但即使针对Urimalsaem的术语缩略语,其类型也不是那么简单。在这方面,为了对Urimalsaem的794个术语缩写进行分类,除了“基本类型”之外,还假设了“扩展类型”和“应用类型”。此外,将与基本类型和扩展类型相结合的“复杂类型”视为单独的类型,而不属于任何类型的则归为“其他类型”。通过这种分类,除“其他类型”外,除4种基本类型外,还细分为11种扩展类型,14种应用类型和1种复杂类型。这一结果清楚地表明,缩略语的类型本身就非常复杂。这些缩略语类型虽然占总体基本类型的比例超过一半,为53.4%,但其扩展型、应用性和复合型的比例总和非常高。在AD类型中,扩展型的比例(15.74%)是基本型的两倍多(16.30%)。另一方面,与AC和AD类型的比例相比,BC和BD类型在缩写方法上的效率并不高,其总和仅为它们的5.66%。说到缩略语类型,也可以看出音节数在缩略语的形成中起着非常重要的作用。另一方面,作为缩略语的结构特征,类型频率和项目频率最高的是AC和AD类型。还注意到AC型首字母缩略词与AD型混合词之间的关系。此外,在术语缩略语中,有些元素以前位或后位反复连续出现。有些是词缀,有些不是。因此,它们可以分别称为“缩写词”。值得注意的是,这些缩略语不仅使我们能够预测当前的缩略语类型,而且还能预测未来的缩略语类型。
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引用次数: 0
On the role of morphology in early spelling in Hebrew and Arabic. 关于形态学在希伯来语和阿拉伯语早期拼写中的作用。
Pub Date : 2023-05-29 DOI: 10.1007/s11525-023-09408-5
Yasmin Shalhoub-Awwad, Ravit Cohen-Mimran

It is well known that learning to spell is a complex and challenging process, especially for young learners, in part because it relies on multiple aspects of linguistic knowledge, such as phonology and morphology. The present longitudinal study investigated the role of morphology in early spelling in two Semitic languages, Hebrew and Arabic, that are structurally similar but differ in the phonological consistency of phoneme to letter mappings ("backward consistency"). Whereas Arabic mappings are mostly one-to-one - allowing children to rely mainly on phonology to spell words correctly, Hebrew has numerous one-to-many phoneme-to-letter mappings that are governed by morphological considerations, thereby precluding a purely phonological spelling strategy. We, therefore, predicted that morphology would make a more substantial contribution to early Hebrew spelling than to Arabic spelling. We tested this prediction in a longitudinal study of two large parallel samples (Arabic, N = 960; Hebrew, N = 680). We assessed general non-verbal ability, morphological awareness (MA), and phonological awareness (PA) in late Kindergarten and spelling in the middle of the first grade with a spelling-to-dictation task. Hierarchical regression analyses revealed that after controlling for age, general intelligence, and phonological awareness, morphological awareness contributed a significant additional 6% variance to Hebrew spelling but only 1% to Arabic word spelling. The results are discussed within the framework of the Functional Opacity Hypothesis (Share, 2008), which we extend to spelling.

众所周知,学习拼写是一个复杂而富有挑战性的过程,尤其是对年轻的学习者来说,部分原因是它依赖于语言学知识的多个方面,如音韵学和形态学。本纵向研究调查了形态在希伯来语和阿拉伯语这两种闪米特语早期拼写中的作用,这两种语言在结构上相似,但在音位到字母映射的语音一致性(“向后一致性”)方面不同。阿拉伯语的映射大多是一对一的,这让孩子们主要依靠音韵学来正确拼写单词,而希伯来语有许多一对多的音位到字母的映射,这些映射受形态学因素的控制,从而排除了纯粹的音韵学拼写策略。因此,我们预测形态学对早期希伯来语拼写的贡献将比对阿拉伯语拼写的贡献更大。我们在对两个大型平行样本(阿拉伯语,N=960;希伯来语,N=680)的纵向研究中测试了这一预测。我们评估了幼儿园后期的一般非语言能力、形态意识(MA)和语音意识(PA),以及一年级中期的拼写任务。分层回归分析显示,在控制了年龄、一般智力和语音意识后,形态意识对希伯来语拼写的贡献显著增加了6%,但对阿拉伯语单词拼写的贡献仅为1%。这些结果是在功能不透明度假说(Share,2008)的框架内讨论的,我们将其扩展到拼写。
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引用次数: 0
The morphologization of German noun-participle combinations. A diachronic case study 德语名分词组合的形态。一个历时性的案例研究
Pub Date : 2023-05-29 DOI: 10.1007/s11525-023-09407-6
Carlotta J. Hübener
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引用次数: 0
The roots of consonant bias in semitic languages: a critical review of psycholinguistic studies of languages with non-concatenative morphology 闪族语言中辅音偏误的根源:对非连接形态语言心理语言学研究的批判性回顾
Pub Date : 2023-05-26 DOI: 10.1007/s11525-023-09409-4
Si Berrebi, Outi Bat-El, A. Meltzer-Asscher
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引用次数: 0
Detection of macrophages in human and rat heart using a single antibody variant 使用单一抗体变体检测人类和大鼠心脏中的巨噬细胞
Pub Date : 2023-05-22 DOI: 10.17816/morph.200003
Valeria V. Guselnikova, Valeria S. Pavlova, V. Razenkova, O. V. Kirik, D. Korzhevskii
BACKGROUND: Resident macrophages of the myocardium are necessary for the normal development and functioning of the cardiovascular system and play an important role in the pathogenesis of a number of cardiovascular diseases. AIM: To develop a universal methodological approach for the immunohistochemical identification of macrophages in the human and rat myocardium. MATERIAL AND METHODS: For the study, samples of the myocardium of people of both sexes aged from 28 to 52 years (n=7) and Wistar female rats (at the age of 15 months, (n=5)) were used. The work was performed using immunohistochemical staining method. RESULTS: The possibility of using polyclonal antibodies against the calcium-binding protein Iba1, which is a well-known microglial marker marker, for the detection of macrophages in the myocardium was shown. An optimal drug processing protocol was developed, the use of which makes it possible to equally effectively detect macrophages in the human and rat myocardium using only one antibody variant. CONCLUSION: A universal methodological approach has been proposed for the identification of macrophages in the human and rat myocardium, which can be successfully used in scientific and clinical diagnostic studies.
背景:心肌巨噬细胞是心血管系统正常发育和功能所必需的,在许多心血管疾病的发病机制中起着重要作用。目的:建立人类和大鼠心肌巨噬细胞免疫组化鉴定的通用方法。材料与方法:本研究采用28 ~ 52岁男女心肌样本(n=7)和15月龄Wistar雌性大鼠(n=5)。采用免疫组织化学染色法。结果:显示了利用钙结合蛋白Iba1多克隆抗体检测心肌巨噬细胞的可能性,Iba1是一种众所周知的小胶质细胞标志物。开发了一种最佳的药物处理方案,该方案的使用使得仅使用一种抗体变体就可以同样有效地检测人和大鼠心肌中的巨噬细胞。结论:提出了一种鉴定人和大鼠心肌巨噬细胞的通用方法,可成功用于科学和临床诊断研究。
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引用次数: 0
期刊
Morphology (Dordrecht, Netherlands)
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