S. Minaev, N. Getman, A. Grigorova, S.S. Dydykin, O. Sumkina, S. Timofeev
Aim - histological study of the structure and thickness of the membranes of the portal vein of the liver and splenic vein in people of different age groups in normal conditions and with portal hypertension. Materials and methods. Sectional material for the study of the portal vein of the liver and splenic vein was obtained from 89 people aged 7 to 30 years who died from injuries incompatible with life. In 57 cases during life, patients had a history of portal hypertension, the remaining 32 cases were considered as controls. Cellular and tissue components of the vein walls were studied on paraffin sections stained with hematoxylin-eosin, as well as according to Van Gieson using Weigert's hematoxylin, picric acid, and fuchsin. Results. It was found that in case of portal hypertension, in comparison with the control, the thickness of the inner and middle membranes of venous vessels significantly increased in all age groups. Pathological features of changes in the thickness and microstructure of the components of the portal vein wall of the liver and splenic vein in topographically different parts of the veins are shown. Conclusions. Pathological changes in the wall of the portal vein of the liver and splenic vein in portal hypertension are pronounced and regular in both young people and children and adolescents, which is an urgent problem for clinical practice. Further study of the structures of GDP and SW will help to form representations of the average stress parameters, the digital values of which have a different range in relation to the norm.
{"title":"Histological features of the structure of the portal vein of the liver and splenic vein in portal hypertension","authors":"S. Minaev, N. Getman, A. Grigorova, S.S. Dydykin, O. Sumkina, S. Timofeev","doi":"10.17816/morph.112247","DOIUrl":"https://doi.org/10.17816/morph.112247","url":null,"abstract":"Aim - histological study of the structure and thickness of the membranes of the portal vein of the liver and splenic vein in people of different age groups in normal conditions and with portal hypertension. \u0000Materials and methods. Sectional material for the study of the portal vein of the liver and splenic vein was obtained from 89 people aged 7 to 30 years who died from injuries incompatible with life. In 57 cases during life, patients had a history of portal hypertension, the remaining 32 cases were considered as controls. Cellular and tissue components of the vein walls were studied on paraffin sections stained with hematoxylin-eosin, as well as according to Van Gieson using Weigert's hematoxylin, picric acid, and fuchsin. \u0000Results. It was found that in case of portal hypertension, in comparison with the control, the thickness of the inner and middle membranes of venous vessels significantly increased in all age groups. Pathological features of changes in the thickness and microstructure of the components of the portal vein wall of the liver and splenic vein in topographically different parts of the veins are shown. \u0000Conclusions. Pathological changes in the wall of the portal vein of the liver and splenic vein in portal hypertension are pronounced and regular in both young people and children and adolescents, which is an urgent problem for clinical practice. Further study of the structures of GDP and SW will help to form representations of the average stress parameters, the digital values of which have a different range in relation to the norm.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87895287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adaptation to climatic conditions influences main characteristics of subjective physical development and morphofunctional state that tend to differ in different geographical regions of the northeast of Russia. A comparative analysis was conducted for basic somatometric indicators to identify differences between representatives of Magadan Region and Chukotka Autonomous District. Material and methods: One hundred and ninety-eight young men aged 17-21 (Koryaks and Evens) from Magadan Region (the city of Magadan) and eighty-seven young men (Chukchi) from Chukotka Autonomous District (the city of Anadyr) participated in the study. Using medical height meter and scale, we measured physical variables and calculated somatometric indices for the examined two groups. Results: somatometric indicators exhibited by modern young male aborigines inhabiting different regions of the Far East demonstrated no significant differences between groups. However, subjective overall body size through the two regions analyzed samples proved to increase as compared to their peers of previous years. Conclusion: Aborigines from both Magadan Region and Chukotka Autonomous District have developed their morphotype with accelerated variables. Changes observed have no dependence upon region of residence or ethnicity.
{"title":"Physical development comparative study among aborigines inhabiting different regions of Russia’s northeast","authors":"I. Averyanova","doi":"10.17816/morph.106184","DOIUrl":"https://doi.org/10.17816/morph.106184","url":null,"abstract":"Adaptation to climatic conditions influences main characteristics of subjective physical development and morphofunctional state that tend to differ in different geographical regions of the northeast of Russia. A comparative analysis was conducted for basic somatometric indicators to identify differences between representatives of Magadan Region and Chukotka Autonomous District. \u0000Material and methods: One hundred and ninety-eight young men aged 17-21 (Koryaks and Evens) from Magadan Region (the city of Magadan) and eighty-seven young men (Chukchi) from Chukotka Autonomous District (the city of Anadyr) participated in the study. Using medical height meter and scale, we measured physical variables and calculated somatometric indices for the examined two groups. Results: somatometric indicators exhibited by modern young male aborigines inhabiting different regions of the Far East demonstrated no significant differences between groups. However, subjective overall body size through the two regions analyzed samples proved to increase as compared to their peers of previous years. \u0000Conclusion: Aborigines from both Magadan Region and Chukotka Autonomous District have developed their morphotype with accelerated variables. Changes observed have no dependence upon region of residence or ethnicity.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82899554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective - development of Klebsiella - Candida arthritis model in Wistar rats. Material and methods. The study was carried out on 20 male Wistar rats, of which 15 animals were injected with a bacterial-fungal suspension by introducing into the cavity of the hock (tarsus) joint Klebsiella-Candida suspension (1: 1) with a microorganism concentration of 106 CFU / ml , using museum strains Klebsiella pneumoniae ICIS - 278 and Candida albicans ATCC 24433 under the control of an X-ray apparatus FireCR +. Five intact animals served as control. On the 15th day of the experiment, after euthanasia, a bacteriological and histological examination of the affected joints was carried out while maintaining their topography. Results. In rats infected with Klebiella-candidiasis suspension, pain syndrome and functional changes typical for arthritis were noted on days 2-3. Bacteriological examination of the affected joints in 75% of rats isolated cultures of Klebsiella pneumoniae, identical, according to PCR, to the original strain, which is part of the bacterial-fungal suspension. At the same time, fungi of the genus Candida, also used in the experiment for infecting animals, were not detected from the affected joints of rats. The reproduced model of Klebsiella-Candida arthritis is characterized by pathomorphological signs of panarthritis, accompanied by purulent inflammation of all joint structures (synovial membrane, cartilage and bone tissue) with the involvement of soft periarticular tissues. Conclusions. The presented model of Klebsiella-fungal arthritis can be used to test new means of antimicrobial (antibacterial and antifungal) therapy, which are an integral component of the treatment of arthritis associated with infection.
{"title":"Klebsiella-candida arthritis model in Wistar rats","authors":"E. I. Danilova","doi":"10.17816/morph.110871","DOIUrl":"https://doi.org/10.17816/morph.110871","url":null,"abstract":"Objective - development of Klebsiella - Candida arthritis model in Wistar rats. \u0000Material and methods. The study was carried out on 20 male Wistar rats, of which 15 animals were injected with a bacterial-fungal suspension by introducing into the cavity of the hock (tarsus) joint Klebsiella-Candida suspension (1: 1) with a microorganism concentration of 106 CFU / ml , using museum strains Klebsiella pneumoniae ICIS - 278 and Candida albicans ATCC 24433 under the control of an X-ray apparatus FireCR +. Five intact animals served as control. On the 15th day of the experiment, after euthanasia, a bacteriological and histological examination of the affected joints was carried out while maintaining their topography. \u0000Results. In rats infected with Klebiella-candidiasis suspension, pain syndrome and functional changes typical for arthritis were noted on days 2-3. Bacteriological examination of the affected joints in 75% of rats isolated cultures of Klebsiella pneumoniae, identical, according to PCR, to the original strain, which is part of the bacterial-fungal suspension. At the same time, fungi of the genus Candida, also used in the experiment for infecting animals, were not detected from the affected joints of rats. The reproduced model of Klebsiella-Candida arthritis is characterized by pathomorphological signs of panarthritis, accompanied by purulent inflammation of all joint structures (synovial membrane, cartilage and bone tissue) with the involvement of soft periarticular tissues. \u0000Conclusions. The presented model of Klebsiella-fungal arthritis can be used to test new means of antimicrobial (antibacterial and antifungal) therapy, which are an integral component of the treatment of arthritis associated with infection.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73544592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.51157/kmor.2022.24.2.311
Gyu-hwan Oh
Korean complex predicate constructions(henceforth CPCs) can be cross-classified with various types, according to case marker/particle realization, expandability of CPCs’ constituents, polysemy of CPCs’ noun, semantic bleaching degree of CPCs’ verbs/adjectives, etc. The wordhood of Korean CPCs vary depending on the types of CPCs. I accounted for the differences observed on the wordhood of Korean CPCs from the perspective of word-formation and described the synchronic formation and change of Korean CPCs. Korean CPCs are formed synchronically through the concatenative process that occurs when clauses are formed in the syntactic component or the substitutional process and concatenative process in the mental lexicon. Korean CPCs which are formed in the mental lexicon are more likely to be word-like, while CPCs which are formed in the syntactic component are more likely to phrase-like. Korean CPCs that are formed synchronically are used in the syntactic component and experiences formal, semantic, and categorial changes. The formal and semantic change of Korean CPCs are related to the realization of the case-marker/particle and metaphor/metonymy, respectively, and the categorial change of Korean CPCs is due to reanalysis. Because of these changes, I pointed out that the wordhood of the Korean CPCs may decrease or increase.
{"title":"Formation Principles and Change Factors of Korean Complex Predicate Constructions","authors":"Gyu-hwan Oh","doi":"10.51157/kmor.2022.24.2.311","DOIUrl":"https://doi.org/10.51157/kmor.2022.24.2.311","url":null,"abstract":"Korean complex predicate constructions(henceforth CPCs) can be cross-classified with various types, according to case marker/particle realization, expandability of CPCs’ constituents, polysemy of CPCs’ noun, semantic bleaching degree of CPCs’ verbs/adjectives, etc. The wordhood of Korean CPCs vary depending on the types of CPCs. I accounted for the differences observed on the wordhood of Korean CPCs from the perspective of word-formation and described the synchronic formation and change of Korean CPCs. Korean CPCs are formed synchronically through the concatenative process that occurs when clauses are formed in the syntactic component or the substitutional process and concatenative process in the mental lexicon. Korean CPCs which are formed in the mental lexicon are more likely to be word-like, while CPCs which are formed in the syntactic component are more likely to phrase-like. Korean CPCs that are formed synchronically are used in the syntactic component and experiences formal, semantic, and categorial changes. The formal and semantic change of Korean CPCs are related to the realization of the case-marker/particle and metaphor/metonymy, respectively, and the categorial change of Korean CPCs is due to reanalysis. Because of these changes, I pointed out that the wordhood of the Korean CPCs may decrease or increase.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73344456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.51157/kmor.2022.24.2.347
Ye-Eun Jeong
This paper aims to clarify the scope of context forming lexical meaning by discussing the difference between literal and contextual meanings in the Korean lexicon from a pragmatic and sociolinguistic view. Literal meaning is the entailed meaning of the constituents, while contextual meaning is the implied meaning of the constituents, with the former including most subordinate compounds. In contextual meaning (α), there is temporary α as well as the more stabilized conventional α. Unlike conventional α that have already solidified into literal meaning, temporary α is actively being formed in both extralinguistic contexts, such as social stereotypes and personal variables, and intralinguistic contexts. The findings in this article can help systematically represent the mental process of context forming lexical meaning.
{"title":"The Scope of Context Forming Lexical Meaning","authors":"Ye-Eun Jeong","doi":"10.51157/kmor.2022.24.2.347","DOIUrl":"https://doi.org/10.51157/kmor.2022.24.2.347","url":null,"abstract":"This paper aims to clarify the scope of context forming lexical meaning by discussing the difference between literal and contextual meanings in the Korean lexicon from a pragmatic and sociolinguistic view. Literal meaning is the entailed meaning of the constituents, while contextual meaning is the implied meaning of the constituents, with the former including most subordinate compounds. In contextual meaning (α), there is temporary α as well as the more stabilized conventional α. Unlike conventional α that have already solidified into literal meaning, temporary α is actively being formed in both extralinguistic contexts, such as social stereotypes and personal variables, and intralinguistic contexts. The findings in this article can help systematically represent the mental process of context forming lexical meaning.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82791755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-30DOI: 10.51157/kmor.2022.24.2.370
Yoonji Choi
As a review of Nakagawa(2020), Information Structure in Spoken Japanese: Particles, Word Order, and Intonation, this article summarizes its main contents, points out its problems, and examines topics comparable to the Korean information structure. Nakagawa(2020) is mainly based on the analysis of the Corpus of Spontaneous Japanese, and uses the frame of referential information status which is a modified version of Prince(1981)’s assumed familiarity taxonomy and the category of topic and focus defined according to ‘controversiality’. The topic particles such as toiuno-wa, wa, COP-kedo/ga, and ∅ are shown to be distributed in different scopes of given-new taxonomy, and the focus particles such as ga, o, and ∅ are claimed to be correlated with the grammatical and semantic properties of NP and the type of focus. Topic and focus are claimed to appear clause-initially and right before the predicate, respectively, and to tend to be uttered in phrasal IUs (intonational units) and clausal IUs, respectively. We point out several problems of Nakagawa(2020) that it needs full discussion of discriminating topic and focus markers, more detailed description of the relationship between IUs and informational status, and reconsidering of so-called information-structure continuity principle. For comparative study of information structure of Korean and Japanese, we propose to investigate the relationship between case particles and focus, and to compare a Japanese topic marker toiuno-wa and a Korean topic marker (i)ran.
{"title":"A review of Nakagawa(2020), Information Structure in Spoken Japanese: Particles, Word Order, and Intonation","authors":"Yoonji Choi","doi":"10.51157/kmor.2022.24.2.370","DOIUrl":"https://doi.org/10.51157/kmor.2022.24.2.370","url":null,"abstract":"As a review of Nakagawa(2020), Information Structure in Spoken Japanese: Particles, Word Order, and Intonation, this article summarizes its main contents, points out its problems, and examines topics comparable to the Korean information structure. Nakagawa(2020) is mainly based on the analysis of the Corpus of Spontaneous Japanese, and uses the frame of referential information status which is a modified version of Prince(1981)’s assumed familiarity taxonomy and the category of topic and focus defined according to ‘controversiality’. The topic particles such as toiuno-wa, wa, COP-kedo/ga, and ∅ are shown to be distributed in different scopes of given-new taxonomy, and the focus particles such as ga, o, and ∅ are claimed to be correlated with the grammatical and semantic properties of NP and the type of focus. Topic and focus are claimed to appear clause-initially and right before the predicate, respectively, and to tend to be uttered in phrasal IUs (intonational units) and clausal IUs, respectively. We point out several problems of Nakagawa(2020) that it needs full discussion of discriminating topic and focus markers, more detailed description of the relationship between IUs and informational status, and reconsidering of so-called information-structure continuity principle. For comparative study of information structure of Korean and Japanese, we propose to investigate the relationship between case particles and focus, and to compare a Japanese topic marker toiuno-wa and a Korean topic marker (i)ran.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81101888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-25DOI: 10.1007/s11525-022-09400-5
Katya Pertsova
{"title":"A case for a binary feature underlying clusivity: the possibility of ABA","authors":"Katya Pertsova","doi":"10.1007/s11525-022-09400-5","DOIUrl":"https://doi.org/10.1007/s11525-022-09400-5","url":null,"abstract":"","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"26 1","pages":"389 - 429"},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75832140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-18DOI: 10.1007/s11525-022-09399-9
Sabine Arndt-Lappe, Robin Schrecklinger, F. Tomaschek
{"title":"Stratification effects without morphological strata, syllable counting effects without counts – modelling English stress assignment with Naive Discriminative Learning","authors":"Sabine Arndt-Lappe, Robin Schrecklinger, F. Tomaschek","doi":"10.1007/s11525-022-09399-9","DOIUrl":"https://doi.org/10.1007/s11525-022-09399-9","url":null,"abstract":"","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"9 1","pages":"433 - 457"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90485776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The work is devoted to the analysis of the role, significance and effectiveness of traditional and innovative teaching methods in the study of histology, cytology and embryology in a medical college. Years of experience have shown that the integration of innovative teaching methods into the existing traditional Russian model is optimal with all the positives that the national high school has accumulated, while the traditional model should be viewed not only as a reserve of conservatism, but as a fundamental basis for innovative transformations.
{"title":"The state and prospects of traditional and innovative methods in the teaching of histology, cytology and embryology in a medical university (debatable aspects)","authors":"N. Shevlyuk, А. А., Е. Б.","doi":"10.17816/morph.110837","DOIUrl":"https://doi.org/10.17816/morph.110837","url":null,"abstract":"The work is devoted to the analysis of the role, significance and effectiveness of traditional and innovative teaching methods in the study of histology, cytology and embryology in a medical college. Years of experience have shown that the integration of innovative teaching methods into the existing traditional Russian model is optimal with all the positives that the national high school has accumulated, while the traditional model should be viewed not only as a reserve of conservatism, but as a fundamental basis for innovative transformations.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78484310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective - to study, the dynamics of catecholamine binding on erythrocytes when modeling the stimulation and blockade of adrenergic regulation mechanisms using the cytological method Material and methods. The number of catecholamine granules on erythrocytes was determined using silver nitrate impregnation under conditions of administration of anapriline -adrenergic receptor blocker (2 mg/kg), acute stress, activation of noradrenergic systems (maprotiline, 10 mg/kg) and a combination of these effects. Results. The number of catecholamine granules in intact animals is 145-155 pieces/40 erythrocytes. Medium-sized granules are more common (0.6-0.9 m). After the administration of a -adrenergic receptor blocker, the total number of catecholamine granules decreases 2.8 times due to large and medium-sized granules. Under conditions of acute stress, the total number of granules increases almost 2 times due to small granules, which may be a sign of sensitization of erythrocyte membranes to catecholamines. Stimulation of the noradrenergic system causes a 20% decrease in the number of catecholamine granules due to a decrease in the number of small and medium sized granules. Under stress against the background of activation of the noradrenergic system, the number of granules on erythrocytes is reduced, which may be a sign of adrenergic receptor desensitization. Conclusions. The number of catecholamine granules on erythrocytes decreases after the administration of a -adrenergic receptor blocker and increases during acute stress. Stimulation of the noradrenergic system is accompanied by a decrease in the binding of catecholamines, especially under conditions of acute stress, which indicates desensitization of erythrocyte adrenergic receptors. The cytological method is sensitive enough to observe the reception of catecholamines by erythrocytes when exposed to adrenergic structures.
{"title":"Morphological manifestations of the dynamics of catecholamines binding by erythrocytes during activation and blockade of adrenergic regulatory mechanisms","authors":"E. V. Kuryanova","doi":"10.17816/morph.110872","DOIUrl":"https://doi.org/10.17816/morph.110872","url":null,"abstract":"Objective - to study, the dynamics of catecholamine binding on erythrocytes when modeling the stimulation and blockade of adrenergic regulation mechanisms using the cytological method \u0000Material and methods. The number of catecholamine granules on erythrocytes was determined using silver nitrate impregnation under conditions of administration of anapriline -adrenergic receptor blocker (2 mg/kg), acute stress, activation of noradrenergic systems (maprotiline, 10 mg/kg) and a combination of these effects. \u0000Results. The number of catecholamine granules in intact animals is 145-155 pieces/40 erythrocytes. Medium-sized granules are more common (0.6-0.9 m). After the administration of a -adrenergic receptor blocker, the total number of catecholamine granules decreases 2.8 times due to large and medium-sized granules. Under conditions of acute stress, the total number of granules increases almost 2 times due to small granules, which may be a sign of sensitization of erythrocyte membranes to catecholamines. Stimulation of the noradrenergic system causes a 20% decrease in the number of catecholamine granules due to a decrease in the number of small and medium sized granules. Under stress against the background of activation of the noradrenergic system, the number of granules on erythrocytes is reduced, which may be a sign of adrenergic receptor desensitization. \u0000Conclusions. The number of catecholamine granules on erythrocytes decreases after the administration of a -adrenergic receptor blocker and increases during acute stress. Stimulation of the noradrenergic system is accompanied by a decrease in the binding of catecholamines, especially under conditions of acute stress, which indicates desensitization of erythrocyte adrenergic receptors. The cytological method is sensitive enough to observe the reception of catecholamines by erythrocytes when exposed to adrenergic structures.","PeriodicalId":74228,"journal":{"name":"Morphology (Dordrecht, Netherlands)","volume":"48 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72462058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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