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Integrin receptor-targeted, doxorubicin-loaded cerium oxide nanoparticles delivery to combat glioblastoma. 以整合素受体为靶向、负载多柔比星的氧化铈纳米颗粒用于抗击胶质母细胞瘤。
Pub Date : 2024-06-20 Epub Date: 2024-06-24 DOI: 10.1080/17435889.2024.2350357
Gayathri Koula, Venu Yakati, Hari Krishnareddy Rachamalla, Keerti Bhamidipati, Muralidharan Kathirvel, Rajkumar Banerjee, Nagaprasad Puvvada

Aim: To assess the chemo-immunomodulatory effects of doxorubicin-loaded cerium oxide nanoparticles coated with oleyl amine-linked cyclic RGDfK peptide (CeNP+Dox+RGD) to target both gliomas and its tumor microenvironment (TME) via integrin receptors. Materials & methods: CeNP+Dox+RGD nanoparticles are synthesized by the sequential addition of cerium III chloride heptahydrate, beta-cyclodextrin, oleic acid, and F127 micelle (CeNP). Doxorubicin was then loaded into CeNPs and coated with oleyl amine-linked cyclic RGDfK peptide to form stable CeNP+Dox+RGD nanoparticles. Results: CeNP+Dox+RGD nanoparticles crossed blood-brain barrier (BBB) effectively and demonstrated threefold enhanced survivability in glioma-bearing mice. The IHC profiling of glial tumor cross-sections showed increased CD80 expression (M1 TAMs) and decreased arginase-1 expression (M2 TAMs). Conclusion: CeNP+Dox+RGD can be an immunotherapeutic treatment option to combat glioblastoma.

目的:评估氧化铈纳米粒子包覆油胺环RGDfK肽(CeNP+Dox+RGD)通过整合素受体靶向胶质瘤及其肿瘤微环境(TME)的化学免疫调节作用。材料与方法CeNP+Dox+RGD纳米粒子由七水氯化铈III、β-环糊精、油酸和F127胶束(CeNP)依次加入合成。然后将多柔比星负载到 CeNPs 中,并包覆上油酸胺连接的环状 RGDfK 肽,形成稳定的 CeNP+Dox+RGD 纳米粒子。结果CeNP+Dox+RGD纳米颗粒能有效穿过血脑屏障(BBB),在胶质瘤小鼠中的存活率提高了三倍。胶质瘤横截面的 IHC 图谱显示,CD80 表达增加(M1 TAMs),精氨酸酶-1 表达减少(M2 TAMs)。结论CeNP+Dox+RGD可作为抗击胶质母细胞瘤的免疫治疗方案。
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引用次数: 0
PLGA-LEC/F127 hybrid nanoparticles loaded with curcumin and their modulatory effect on monocytes. 载姜黄素的 PLGA-LEC/F127 混合纳米粒子及其对单核细胞的调节作用
Pub Date : 2024-06-20 Epub Date: 2024-06-26 DOI: 10.1080/17435889.2024.2357530
Jennifer T Cruz, Karen Álvarez, Víctor H Orozco, Mauricio Rojas, Raul A Morales-Luckie, Luis F Giraldo

Aim: To investigate the effect of surfactant type on curcumin-loaded (CUR) PLGA nanoparticles (NPs) to modulate monocyte functions. Materials & methods: The nanoprecipitation method was used, and PLGA NPs were designed using Pluronic F127 (F127) and/or lecithin (LEC) as surfactants. Results: The Z-average of the NPs was <200 nm, they had a spherical shape, Derjaguin-Muller-Toporov modulus >0.128 MPa, they were stable during storage at 4°C, ζ-potential ∼-40 mV, polydispersity index <0.26 and % EE of CUR >94%. PLGA-LEC/F127 NPs showed favorable physicochemical and nanomechanical properties. These NPs were bound and internalized mainly by monocytes, suppressed monocyte-induced reactive oxygen species production, and decreased the ability of monocytes to modulate T-cell proliferation. Conclusion: These results demonstrate the potential of these NPs for targeted therapy.

目的:研究表面活性剂类型对姜黄素负载(CUR)PLGA纳米颗粒(NPs)调节单核细胞功能的影响。材料与方法:采用纳米沉淀法,以 Pluronic F127(F127)和/或卵磷脂(LEC)为表面活性剂设计 PLGA NPs。结果表明NPs的Z-平均值为0.128 MPa,在4°C条件下储存稳定,ζ电位∼-40 mV,多分散指数为94%。PLGA-LEC/F127 NPs 表现出良好的物理化学和纳米力学性能。这些 NPs 主要被单核细胞结合和内化,抑制了单核细胞诱导的活性氧产生,并降低了单核细胞调节 T 细胞增殖的能力。结论这些结果证明了这些 NPs 在靶向治疗方面的潜力。
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引用次数: 0
Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection. 壳聚糖装饰的油小体负载盐酸普萘洛尔氢凝胶被重新用于治疗白色念珠菌阴道感染。
Pub Date : 2024-06-20 DOI: 10.1080/17435889.2024.2359364
Moaz A Eltabeeb, Menna M Abdellatif, Mohamed A El-Nabarawi, Mahmoud H Teaima, Mohammed I A Hamed, Khaled M Darwish, Mariam Hassan, Ahmed Me Hamdan, Raghda Rabe Hamed

Aim: Our investigation aims to estimate the antifungal effect of propranolol hydrochloride (PNL). Methods: Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and amount of drug released after 6 h Q6h (%). Results: The optimal OL showed a rounded shape with optimum characteristics. The ex-vivo permeation and confocal laser scanning microscopy verified the prolonged release and well deposition of PNL-loaded OLs-gel. The in-silico assessment demonstrated the good stability of PNL with OLs' ingredients. In vivo evaluations for PNL-loaded OLs-gel showed a good antifungal impact against Candida albicans with good safety. Conclusion: This work highlights the potential of PNL-loaded OLs-gel as a potential treatment for candida vaginal infection.

目的:我们的调查旨在评估盐酸普萘洛尔(PNL)的抗真菌效果。方法:采用薄膜水合法制造油小体(OLs),并评估其抗真菌效果(单位:mg/g):通过薄膜水合法制备油小体(OLs),并评估其包载效率(EE%)、粒度(PS)、多分散指数(PDI)、Zeta 电位(ZP)以及 6 小时 Q6h 后的药物释放量(%)。结果显示最佳 OL 呈圆形,具有最佳特性。体内外渗透和共聚焦激光扫描显微镜验证了负载 PNL 的 OLs-凝胶的长期释放和良好沉积。室内评估表明,PNL 与 OL 成分具有良好的稳定性。载入 PNL 的 OLs-凝胶的体内评估显示,它对白色念珠菌具有良好的抗真菌效果,而且安全性良好。结论这项研究强调了 PNL 负载 OLs-凝胶作为治疗念珠菌阴道感染的潜在药物的潜力。
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引用次数: 0
Harnessing exosomes and plant-derived exosomes as nanocarriers for the efficient delivery of plant bioactives. 利用外泌体和植物源外泌体作为纳米载体,高效输送植物生物活性物质。
Pub Date : 2024-06-20 DOI: 10.1080/17435889.2024.2354159
Pooja Kathait, Pradeep Kumar Patel, Alakh N Sahu

Exosomes, a category of extracellular vesicle (EV), are phospholipid bilayer structures ranging from 30 to 150 nm, produced by various organisms through the endosomal pathway. Recent studies have established the utilization of exosomes as nanocarriers for drug distribution across various therapeutic areas including cancer, acute liver injury, neuroprotection, oxidative stress, inflammation, etc. The importance of plant-derived exosomes and exosome vesicles derived from mammalian cells or milk, loaded with potent plant bioactives for various therapeutic indications are discussed along with insights into future perspectives. Moreover, this review provides a detailed understanding of exosome biogenesis, their composition, classification, stability of different types of exosomes, and different routes of administration along with the standard techniques used for isolating, purifying, and characterizing exosomes.

外泌体(Exosomes)是细胞外囊泡(EV)的一种,是由各种生物体通过内泌体途径产生的磷脂双层结构,直径在 30 到 150 nm 之间。最近的研究证实,外泌体可作为纳米载体用于药物分配,涉及癌症、急性肝损伤、神经保护、氧化应激、炎症等多个治疗领域。本综述讨论了植物源性外泌体和从哺乳动物细胞或牛奶中提取的外泌体囊泡的重要性,这些囊泡中装载了有效的植物生物活性物质,可用于各种治疗适应症,并对未来前景进行了展望。此外,这篇综述还详细介绍了外泌体的生物发生、组成、分类、不同类型外泌体的稳定性、不同的给药途径以及用于分离、纯化和表征外泌体的标准技术。
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引用次数: 0
VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis. 用于诊断、监测和治疗动脉粥样硬化的 VCAM-1 靶向纳米粒子。
Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.2217/nnm-2023-0282
Rita Castro, James H Adair, Andrea M Mastro, Thomas Neuberger, Gail L Matters

Vascular cell adhesion molecule-1 (VCAM-1) was identified over 2 decades ago as an endothelial adhesion receptor involved in leukocyte recruitment and cell-based immune responses. In atherosclerosis, a chronic inflammatory disease of the blood vessels that is the leading cause of death in the USA, endothelial VCAM-1 is robustly expressed beginning in the early stages of the disease. The interactions of circulating immune cells with VCAM-1 on the activated endothelial cell surface promote the uptake of monocytes and the progression of atherosclerotic lesions in susceptible vessels. Herein, we review the role of VCAM-1 in atherosclerosis and the use of VCAM-1 binding peptides, antibodies and aptamers as targeting agents for nanoplatforms for early detection and treatment of atherosclerotic disease.

血管细胞粘附分子-1(VCAM-1)早在二十多年前就被确认为一种内皮粘附受体,参与白细胞的招募和基于细胞的免疫反应。动脉粥样硬化是一种慢性血管炎症性疾病,是美国人死亡的主要原因,在这种疾病的早期阶段,血管内皮 VCAM-1 就开始大量表达。循环免疫细胞与活化内皮细胞表面的 VCAM-1 相互作用,促进了单核细胞的吸收和易感血管中动脉粥样硬化病变的进展。在此,我们回顾了 VCAM-1 在动脉粥样硬化中的作用,以及将 VCAM-1 结合肽、抗体和适配体作为纳米平台的靶向药物用于动脉粥样硬化疾病的早期检测和治疗。
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引用次数: 0
Biocompatible carbon quantum dots as versatile imaging nanotrackers of fungal pathogen - Candida albicans. 生物相容性碳量子点作为真菌病原体--白色念珠菌的多功能成像纳米追踪器。
Pub Date : 2024-04-01 Epub Date: 2024-03-01 DOI: 10.2217/nnm-2023-0292
Anam Rais, Shubham Sharma, Prashant Mishra, Luqman Ahmad Khan, Tulika Prasad

Aim: The development of carbon quantum dots (C-QDs) as nanotrackers to understand drug-pathogen interactions, virulence and multidrug resistance. Methods: Microwave synthesis of C-QDs was performed using citric acid and polyethylene glycol. Further, in vitro toxicity was evaluated and imaging applications were demonstrated in Candida albicans isolates. Results: Well-dispersed, ultra small C-QDs exhibited no cyto/microbial/reactive oxygen species-mediated toxicity and internalized effectively in Candida yeast and hyphal cells. C-QDs were employed for confocal imaging of drug-sensitive and -resistant cells, and a study of the yeast-to-hyphal transition using atomic force microscopy in Candida was conducted for the first time. Conclusion: These biocompatible C-QDs have promising potential as next-generation nanotrackers for in vitro and in vivo targeted cellular and live imaging, after functionalization with biomolecules and drugs.

目的:开发作为纳米追踪器的碳量子点(C-QDs),以了解药物与病原体之间的相互作用、毒性和多药耐药性。方法:微波合成碳量子点(C-QDs):使用柠檬酸和聚乙二醇微波合成 C-QDs。此外,还评估了体外毒性,并在白色念珠菌分离物中演示了成像应用。结果:分散良好的超小型 C-QDs 没有表现出细胞/微生物/活性氧介导的毒性,并能在白色念珠菌酵母和芽孢细胞中有效内化。C-QDs 被用于对药物敏感和耐药细胞的共聚焦成像,并首次利用原子力显微镜研究了念珠菌从酵母到芽孢的转变过程。结论这些具有生物相容性的 C-QDs 在与生物分子和药物功能化后,有望成为用于体外和体内靶向细胞和活体成像的下一代纳米追踪器。
{"title":"Biocompatible carbon quantum dots as versatile imaging nanotrackers of fungal pathogen - <i>Candida albicans</i>.","authors":"Anam Rais, Shubham Sharma, Prashant Mishra, Luqman Ahmad Khan, Tulika Prasad","doi":"10.2217/nnm-2023-0292","DOIUrl":"10.2217/nnm-2023-0292","url":null,"abstract":"<p><p><b>Aim:</b> The development of carbon quantum dots (C-QDs) as nanotrackers to understand drug-pathogen interactions, virulence and multidrug resistance. <b>Methods:</b> Microwave synthesis of C-QDs was performed using citric acid and polyethylene glycol. Further, <i>in vitro</i> toxicity was evaluated and imaging applications were demonstrated in <i>Candida albicans</i> isolates. <b>Results:</b> Well-dispersed, ultra small C-QDs exhibited no cyto/microbial/reactive oxygen species-mediated toxicity and internalized effectively in <i>Candida</i> yeast and hyphal cells. C-QDs were employed for confocal imaging of drug-sensitive and -resistant cells, and a study of the yeast-to-hyphal transition using atomic force microscopy in <i>Candida</i> was conducted for the first time. <b>Conclusion:</b> These biocompatible C-QDs have promising potential as next-generation nanotrackers for <i>in vitro</i> and <i>in vivo</i> targeted cellular and live imaging, after functionalization with biomolecules and drugs.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanovesicular ultraflexible invasomes and invasomal gel for transdermal delivery of phytopharmaceuticals. 用于植物药透皮给药的纳米囊状超柔性内生体和内生体凝胶。
Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.2217/nnm-2024-0029
Alakh N Sahu, Debadatta Mohapatra, Pratap Chandra Acharya

Tweetable abstract Invasomes and invasomal gel are ultraflexible, soft vesicular, phospholipid based nanocarriers with deeper skin penetration ability for transdermal applications of drugs and phytopharmaceuticals.

Tweetable 摘要 Invasomes 和 invasomal gel 是一种超柔韧、软泡状、磷脂基纳米载体,具有更深的皮肤渗透能力,可用于药物和植物药的透皮应用。
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引用次数: 0
Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain. 含有流感双凝集素和 M2 外结构域的病毒样颗粒诱导的交叉保护。
Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI: 10.2217/nnm-2023-0353
Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Min-Ju Kim, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Aims: To develop an effective universal vaccine against antigenically different influenza viruses. Materials & methods: We generated influenza virus-like particles (VLPs) expressing the H1 and H3 antigens with or without M2e5x. VLP-induced immune responses and crossprotection against H1N1, H3N2 or H5N1 viruses were assessed to evaluate their protective efficacy. Results: H1H3M2e5x immunization elicited higher crossreactive IgG antibodies than H1H3 VLPs. Upon challenge, both VLPs enhanced lung IgG, IgA and germinal center B-cell responses compared with control. While these VLPs conferred protection, H1H3M2e5x showed greater lung viral load reduction than H1H3 VLPs with minimal body weight loss. Conclusion: Utilizing VLPs containing dual-hemagglutinin, along with M2e5x, can be a vaccination strategy for inducing crossprotection against influenza A viruses.

目的:针对抗原不同的流感病毒研发有效的通用疫苗。材料与方法:我们生成了表达 H1 和 H3 抗原的流感病毒样颗粒(VLPs),其中含有或不含 M2e5x。评估了 VLP 诱导的免疫反应以及对 H1N1、H3N2 或 H5N1 病毒的交叉保护作用,以评价其保护效力。结果与H1H3 VLPs相比,H1H3M2e5x免疫可引起更高的交叉反应IgG抗体。与对照组相比,这两种VLP在接受挑战时都能增强肺部IgG、IgA和生殖中心B细胞反应。虽然这些 VLPs 能提供保护,但与 H1H3 VLPs 相比,H1H3M2e5x 能更有效地减少肺部病毒载量,而且体重减轻幅度极小。结论利用含有双凝集素和 M2e5x 的 VLP 可以作为一种疫苗接种策略,诱导对甲型流感病毒的交叉保护。
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引用次数: 0
pH-sensitive docetaxel-loaded chitosan/thiolated hyaluronic acid polymeric nanoparticles for colorectal cancer. 用于治疗结直肠癌的 pH 值敏感的多西他赛负载壳聚糖/硫醇化透明质酸聚合物纳米粒子。
Pub Date : 2024-04-01 Epub Date: 2024-02-09 DOI: 10.2217/nnm-2023-0318
Sobia Noreen, Fahad Pervaiz, Muhammad Ijaz, Muhammad Farhan Hanif, Jam Riyan Hamza, Hassan Mahmood, Hina Shoukat, Irsah Maqbool, Muhammad Azeem Ashraf

Aim: This study aimed to develop and evaluate pH-sensitive docetaxel-loaded thiolated hyaluronic acid (HA-SH) nanoparticles (NPs) for targeted treatment of colon cancer. Materials & methods: HA-SH, synthesized via oxidation and subsequent covalent linkage to cysteamine, served as the precursor for developing HA-SH NPs through polyelectrolyte complexation involving chitosan and thiol-bearing HA. Results & conclusion: HA-SH NPs displayed favorable characteristics, with small particle sizes (184-270 nm), positive zeta potential (15.4-18.6 mV) and high entrapment efficiency (91.66-95.02%). In vitro, NPs demonstrated potent mucoadhesion and enhanced cytotoxicity compared with free docetaxel. In vivo assessments confirmed safety and biocompatibility, suggesting HA-SH NPs as promising pH-sensitive drug carriers with enhanced antitumor activity for colorectal cancer treatments.

目的:本研究旨在开发和评估pH值敏感的多西他赛硫醇化透明质酸(HA-SH)纳米粒子(NPs),用于结肠癌的靶向治疗。材料与方法:HA-SH通过氧化合成,然后与半胱胺共价连接,作为前体,通过壳聚糖和含硫醇的HA的聚电解质复合物开发HA-SH NPs。结果与结论HA-SH NPs 表现出良好的特性:粒径小(184-270 nm)、ZETA 电位正(15.4-18.6 mV)、包载效率高(91.66-95.02%)。与游离多西他赛相比,NPs 在体外表现出强大的粘附性和更强的细胞毒性。体内评估证实了其安全性和生物相容性,表明HA-SH NPs是一种具有良好pH值敏感性的药物载体,可增强结直肠癌治疗的抗肿瘤活性。
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引用次数: 0
Tannin-albumin particles as stable carriers of medicines. 作为药物稳定载体的单宁-白蛋白颗粒。
Pub Date : 2024-04-01 Epub Date: 2024-02-13 DOI: 10.2217/nnm-2023-0275
Nelli Ohanyan, Narek Abelyan, Arpi Manukyan, Vardan Hayrapetyan, Samvel Chailyan, Susanna Tiratsuyan, Kristine Danielyan

Background: The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines. Methods: Numerous chromatographic and analytical methods, docking analyses and in vivo testing were applied and used. Results: Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of in vivo experiments proved that tannin-albumin particles are more stable than albumin particles. Conclusion: Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.

背景:药物的有效性取决于其在治疗部位的蓄积以及在血液循环中的时间。本研究的目的是制造稳定的白蛋白/单宁(punicalagin、punicalin)颗粒,用于药物的输送。研究方法应用和使用了多种色谱和分析方法、对接分析和体内测试。结果获得了稳定的单宁-白蛋白/药物颗粒,其直径为 100 nm。体内实验结果证明,单宁-白蛋白颗粒比白蛋白颗粒更稳定。结论根据实验和对接分析,这些稳定的颗粒可以携带更多不同化学结构的药物。
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引用次数: 0
期刊
Nanomedicine (London, England)
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