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Revue francophone des laboratoires : RFL最新文献

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Greffe d'utérus, dix ans déjà ! 子宫移植，已经十年了！
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76536-9
Jean-Marie Manus
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引用次数: 0
Sédentarité, guerre à l’immobilisme au bureau 久坐不动的办公室战争
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76524-2
Jean-Marie Manus
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引用次数: 0
Stratégie et lutte contre la résistance antimicrobienne 抗菌素耐药性战略
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76538-2
Sylvain Godreuil
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引用次数: 0
Autisme et gravidité aux États-Unis 美国的自闭症和重力
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76526-6
Jean-Marie Manus
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引用次数: 0
Pratique du "chemsex" et plateformes numériques 性行为与数字平台
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76534-5
Jean-Marie Manus
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引用次数: 0
Une Omerta française Secrets d’enfance 法国奥默塔的童年秘密
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76529-1
Jean-Marie Manus
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引用次数: 0
Textes juridiques 法律文本
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76532-1
Jean-Marie Manus
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引用次数: 0
Pénurie de gynécologues : un débat récurrent 反复辩论的妇科医生短缺
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76533-3
Jean-Marie Manus
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引用次数: 0
Des idées d’articles ? 有文章的想法吗？
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76537-0
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引用次数: 0
Le suivi thérapeutique pharmacologique des antibiotiques, une arme pour lutter contre la résistance aux antibiotiques ? 抗生素的药理学治疗监测，作为对抗抗生素耐药性的武器？
Revue francophone des laboratoires : RFL
Pub Date : 2026-01-01 DOI: 10.1016/S1773-035X(26)76539-4
Yoann Cazaubon , Jean-Joseph Bendjilali-Sabiani

Résumé

Le suivi thérapeutique pharmacologique (STP) des antibiotiques vise à optimiser l’efficacité et à prévenir la toxicité tout en limitant l’émergence de résistances. Cet article parcourt les jalons de l’histoire de la mise en place du STP des antibiotiques, son adoption en pratique clinique, l’apparition et l’évolution des recommandations du STP, et son intérêt selon les particularités des populations à traiter. Nous discutons également des approches proactives intégrant l’intelligence artificielle et/ou la modélisation pharmacocinétique de population, puis envisageons un futur où les données des dossiers patients informatisés permettraient des ajustements individualisés en boucle fermée.

Abstract

Therapeutic drug monitoring (TDM) of antibiotics aims to optimize efficacy and prevent toxicity while limiting the emergence of resistance. This article covers the history of antibiotic TDM implementation, its clinical adoption, the grading of recommendations based on evidence levels, and its relevance across different patient populations to treat. We also discuss proactive approaches integrating artificial intelligence and/or population pharmacokinetic modeling, and envision a future where electronic health records enable real-time individualized dosing adjustments in a closed-loop system.
摘要抗生素的药理随访（STP）旨在优化疗效和预防毒性，同时限制耐药性的出现。本文回顾了STP在临床实践中的应用、STP建议的出现和演变，以及它对治疗人群的特殊性的兴趣。我们还讨论了集成人工智能和/或药物动力学人群建模的主动方法，然后设想了一个未来，在这个未来，计算机病历数据将允许在闭环中进行个性化调整。摘要抗生素治疗药物监测（TDM）旨在优化疗效和预防毒性，同时限制耐药性的出现。本文涵盖了抗生素TDM实施的历史、其临床采用、基于证据水平的建议的分级，以及其在不同患者群体中的相关性。我们还讨论了集成人工智能和/或人口药代动力学模型的主动方法，并设想未来电子健康记录能够在闭环系统中实现实时个性化剂量调整。
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引用次数: 0
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