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Wearable electronics for skin wound monitoring and healing. 用于皮肤伤口监测和愈合的可穿戴电子设备。
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.13
Shubham Patel, Faheem Ershad, Min Zhao, Roslyn Rivkah Isseroff, Bin Duan, Yubin Zhou, Yong Wang, Cunjiang Yu

Wound healing is one of the most complex processes in the human body, supported by many cellular events that are tightly coordinated to repair the wound efficiently. Chronic wounds have potentially life-threatening consequences. Traditional wound dressings come in direct contact with wounds to help them heal and avoid further complications. However, traditional wound dressings have some limitations. These dressings do not provide real-time information on wound conditions, leading clinicians to miss the best time for adjusting treatment. Moreover, the current diagnosis of wounds is relatively subjective. Wearable electronics have become a unique platform to potentially monitor wound conditions in a continuous manner accurately and even to serve as accelerated healing vehicles. In this review, we briefly discuss the wound status with some objective parameters/biomarkers influencing wound healing, followed by the presentation of various novel wearable devices used for monitoring wounds and accelerating wound healing. We further summarize the associated device working principles. This review concludes by highlighting some major challenges in wearable devices toward wound healing that need to be addressed by the research community.

伤口愈合是人体最复杂的过程之一,由许多细胞事件密切协调以有效修复伤口。慢性伤口有潜在的危及生命的后果。传统的伤口敷料直接与伤口接触,以帮助伤口愈合并避免进一步的并发症。然而,传统的伤口敷料有一些局限性。这些敷料不能提供伤口状况的实时信息,导致临床医生错过了调整治疗的最佳时机。此外,目前对伤口的诊断相对主观。可穿戴电子设备已经成为一个独特的平台,可以连续准确地监测伤口状况,甚至可以作为加速愈合的工具。在这篇综述中,我们简要地讨论了影响伤口愈合的一些客观参数/生物标志物的伤口状态,然后介绍了各种用于监测伤口和加速伤口愈合的新型可穿戴设备。进一步总结了相关器件的工作原理。这篇综述最后强调了可穿戴设备在伤口愈合方面的一些主要挑战,这些挑战需要研究界来解决。
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引用次数: 11
Recent advances in flexible and soft gel-based pressure sensors 柔性和软凝胶压力传感器的最新进展
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.16
Gui-zhen Sun, Peng Wang, Yongxiang Jiang, Hongchang Sun, Chuizhou Meng, Shijie Guo
Gels, as typical flexible and soft materials, possess the intrinsic merits of transparent bionic structures, superior mechanical properties and excellent elasticity and viscosity. Recently, gel-based materials have attracted significant attention as a result of their broad and promising applications in biomedical, energy storage, light emission, actuator, military and aerospace devices, especially the intelligent sensing for human-related applications. Among the various flexible and soft pressure sensors, gel-based ones have been gradually studied as an emerging hot research topic. This review focuses on the latest findings in the rapidly developing field of gel-based pressure sensors. Firstly, the classification and properties of the three types of gels and their corresponding fabrication methods are introduced. Secondly, the four basic working principles of pressure sensors are summarized with a comparison of their advantages and disadvantages, followed by an introduction to the construction of pressure sensors based on gel structures. Thirdly, the latest representative research on the three types of gel-based materials towards various wearable sensing applications, including electronic skin, human motion capture, healthcare and rehabilitation, physiological activity monitoring and human-machine interactions, is comprehensively reviewed. Finally, a summary of the remaining challenges and an outline of the development trend for this field are presented.
凝胶是一种典型的柔性软质材料,具有透明仿生结构、优越的力学性能和优异的弹性粘度等内在优点。近年来,凝胶基材料在生物医学、储能、发光、致动器、军事和航空航天器件,特别是与人体相关的智能传感等领域的广泛应用引起了人们的广泛关注。在各种柔性和软性压力传感器中,凝胶型压力传感器逐渐成为一个新兴的研究热点。本文综述了凝胶基压力传感器的最新研究进展。首先,介绍了三种凝胶的分类、性质及其制备方法。其次,总结了压力传感器的四种基本工作原理,比较了它们的优缺点,然后介绍了基于凝胶结构的压力传感器的构造。第三,全面综述了三种凝胶基材料在电子皮肤、人体运动捕捉、医疗康复、生理活动监测和人机交互等可穿戴传感领域的最新代表性研究。最后,总结了该领域仍存在的挑战,并概述了该领域的发展趋势。
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引用次数: 4
A brief review on miniature flexible and soft tactile sensors for interventional catheter applications 介入导管微型柔性和软触觉传感器的研究进展
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.05
Yurui Li, Peng Wang, Chuizhou Meng, Wenqiang Chen, Longyuan Zhang, Shijie Guo
Interventional surgery has the advantages of small skin incision, little bleed loss, low postoperative infection and short recovery time, and thus has gradually become the preferred surgical approach over traditional open surgeries. Even though great achievements have been made towards clinical applications, limitations still exist, among which the loss of natural tactile perception of surgeons due to their indirect touch sense along the long catheter to the intervening human tissue is the crucial one. In recent years, researchers have dedicated great efforts in developing advanced medical catheters with smart tactile perception ability and made considerable progress. In this regard, we review the most recent development on the state-of-the-art miniature flexible and soft tactile sensors that are able to be integrated in the tip or on the side wall of medical catheters, with focus on the sensing mechanism, design requirement, device configuration and sensing performance of different types of sensors as well as their application demonstration in synthetic anatomical models and in-vivo animal experiment. After reviewing the representative research work, challenges that still exist are summarized and prospects toward future development are put forward.
介入手术具有皮肤切口小、出血量少、术后感染少、恢复时间短等优点,已逐渐成为传统开放手术的首选手术方式。尽管在临床应用方面取得了很大的成就,但仍然存在局限性,其中最关键的是外科医生由于沿长导管对介入人体组织的间接触觉而导致的自然触觉丧失。近年来,研究人员致力于开发具有智能触觉感知能力的先进医用导管,并取得了长足的进展。本文综述了可集成于医用导管尖端或侧壁的微型柔性和柔软触觉传感器的最新研究进展,重点介绍了不同类型传感器的传感机理、设计要求、设备配置和传感性能,以及在合成解剖模型和体内动物实验中的应用演示。在回顾了代表性研究工作的基础上,总结了仍存在的挑战,并对未来的发展提出了展望。
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引用次数: 2
Crosslinked organosulfur-based self-assembled monolayers: formation and applications 交联有机硫基自组装单层:形成和应用
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.04
Tianlang Yu, Maria D. Marquez, H. Tran, T. Lee
Self-assembled monolayers (SAMs) have found use in diverse applications that range from corrosion prevention to biosensing. However, for all of these applications, stability remains a key challenge for the utilization of SAMs. Over the last decade, intermolecular crosslinking as a method to enhance the thermal and chemical stability of SAMs has attracted increased attention from scientists and engineers. As such, this review introduces a variety of crosslinked SAMs: (1) aromatic thiol-based SAMs; (2) olefinic- and acetylenic-based alkanethiols; (3) other aliphatic alkanethiols; (4) silane-based alkanethiols; (5) boronic acid-based alkanethiols; and (6) crosslinked SAMs realized by hydrogen bonding. By offering insight into the structure-application relationships of the aforementioned SAMs, this review seeks to inspire researchers toward the development of new classes of SAMs with enhanced stabilities and working lifetimes.
自组装单层膜(SAMs)已经在从防腐到生物传感的各种应用中得到了应用。然而,对于所有这些应用程序,稳定性仍然是使用sam的一个关键挑战。在过去的十年中,分子间交联作为一种提高sam热稳定性和化学稳定性的方法越来越受到科学家和工程师的关注。因此,本文介绍了各种交联地对空导弹:(1)芳香硫醇基地对空导弹;(2)烯烃基和乙炔基烷烃硫醇;(三)其他脂肪族烷烃硫醇;(4)硅烷基烷硫醇;(5)硼酸基烷硫醇;(6)氢键实现的交联sam。通过对上述地对空导弹的结构-应用关系的深入研究,本综述旨在激励研究人员开发具有更高稳定性和使用寿命的新型地对空导弹。
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引用次数: 2
Flexible, high-strength, and porous nano-nano composites based on bacterial cellulose for wearable electronics: a review 基于细菌纤维素的可穿戴电子产品柔性、高强度、多孔纳米-纳米复合材料的研究进展
Pub Date : 2022-01-01 DOI: 10.20517/ss.2021.19
Fangyi Guan, C. Guo
Portable flexible electronics based on petroleum-based polymers have stepped onto the stage of modern technology. Increasing environmental problems facilitate emerging technologies based on cellulose because of its abundant sources and the nature of CO2 consumption and biodegradability. Bacterial cellulose (BC) stands out among all cellulose materials because of its unique features, including the abundant hydrogen bonds, small diameter, three-dimensional nano-networked structures, high purity and crystallinity, and the degree of polymerization. The adequate properties impart BC and its nano-nano composites with superior balance among ductility, strength, and porosity, which are crucial for wearables. The principles of this balance, the fabrication of the nano-nano composites, and the wearable electronic applications based on BC are discussed in detail in this review.
以石油基聚合物为基础的便携式柔性电子产品已经登上了现代技术的舞台。日益严重的环境问题促进了基于纤维素的新兴技术,因为它的丰富来源和二氧化碳消耗的性质和生物降解性。细菌纤维素(BC)以其丰富的氢键、小直径、三维纳米网状结构、高纯度和结晶度、聚合度等独特的特性在所有纤维素材料中脱颖而出。适当的性能赋予BC及其纳米-纳米复合材料在延展性,强度和孔隙率之间取得良好的平衡,这对可穿戴设备至关重要。本文就这种平衡的原理、纳米-纳米复合材料的制备及其在可穿戴电子领域的应用进行了综述。
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引用次数: 6
Stiffness-tunable and shape-locking soft actuators based on 3D-printed hybrid multi-materials 基于3d打印复合材料的刚度可调形状锁定软执行器
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.19
Soft actuators have been receiving tremendous attention as a result of their excellent adaptability to the environment. However, due to their inherently low stiffness, soft actuators are difficult to adapt to high-load tasks. Despite previous efforts in developing stiffness-tunable actuators by utilizing variable stiffness materials, they still suffer from limitations, including relatively low load and locking capacity to grasp weights and difficulties regarding their fabrication with complex structures. This work reports a novel stiffness-tunable and shape-locking soft (Tri-S) actuator using hybrid multi-material 3D printing. The Tri-S actuator consists of polylactic acid, thermoplastic polyurethane and a flexible carbon fiber heating wire. Its stiffness can be effectively tuned by Joule heating. A soft robotic gripper equipped with three Tri-S actuators demonstrates their stiffness-tunable and shape-locking capability by grasping and holding objects of various shapes and weights. The gripper can grasp weights up to 2.2 kg with an external driving force by tuning the stiffness and hold weights up to 310 g depending on its own shape locking without an external driving power source.
软执行器由于其对环境的良好适应性而受到极大的关注。然而,由于其固有的低刚度,软执行器难以适应高负载任务。尽管以前在利用可变刚度材料开发刚度可调致动器方面做出了努力,但它们仍然存在局限性,包括相对较低的负载和锁定能力,以抓住重量,以及在复杂结构中制造困难。这项工作报告了一种使用混合多材料3D打印的新型刚度可调和形状锁定软(Tri-S)致动器。Tri-S执行器由聚乳酸、热塑性聚氨酯和柔性碳纤维发热丝组成。焦耳加热可以有效地调节其刚度。一个装有3个Tri-S驱动器的柔性机器人抓手,通过抓握不同形状和重量的物体,展示了其刚度可调和形状锁定能力。在没有外部驱动电源的情况下,通过调整刚度,抓手可以抓住2.2 kg的重量,根据自身形状锁定可以抓住310 g的重量。
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引用次数: 2
Biocompatible composite thin-film wearable piezoelectric pressure sensor for monitoring of physiological and muscle motions 用于监测生理和肌肉运动的生物相容性复合薄膜可穿戴压电压力传感器
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.06
Nam-in Kim, Jong Moon Lee, Mina Moradnia, Jie Chen, S. Pouladi, Miad Yarali, Ja Yeon Kim, M. Kwon, T. R. Lee, J. Ryou
Whereas piezoelectric pressure sensors (PPSs) have been applied in the monitoring of human body movement and physiological parameters, they show inherent limitations in wearable applications, including toxicity, degradation, and brittleness. In this study, we develop safe, stable, and mechanically flexible composite thin films consisting of polyvinylidene fluoride (PVDF), BaTiO3 nanoparticles (BTO-NPs), and textured aluminum nitride (AlN) thin film for the demonstration of wearable PPS with enhanced output performance and biocompatibility. The PPS made of BTO-NP-embedded-PVDF and AlN film on Cu foil is attached to different parts of human body to measure different output voltages depending on the physiological and physical stimulus. The simple bending (from breathing, chewing, and swallowing), joint motions (at wrist, elbow, and finger), and low- (from eyeball movement) and high-pressure applications (by squat, lunge, and walking) are measured. Our PVDF+BTO-NP/AlN-PPS (PBA-PPS) device has the potential for personal safety, healthcare, and activity monitoring applications with easy wearability.
虽然压电压力传感器(pps)已经应用于监测人体运动和生理参数,但它们在可穿戴应用中表现出固有的局限性,包括毒性、降解和脆性。在这项研究中,我们开发了由聚偏氟乙烯(PVDF)、BaTiO3纳米颗粒(BTO-NPs)和纹理化氮化铝(AlN)薄膜组成的安全、稳定、机械柔性的复合薄膜,用于展示具有增强输出性能和生物相容性的可穿戴PPS。将bto - np嵌入pvdf和铜箔上的AlN薄膜制成PPS,附着在人体的不同部位,根据生理和物理刺激测量不同的输出电压。测量简单的弯曲(呼吸、咀嚼和吞咽)、关节运动(手腕、肘部和手指)和低(眼球运动)和高压运动(下蹲、弓步和行走)。我们的PVDF+BTO-NP/AlN-PPS (PBA-PPS)设备具有易于穿戴的个人安全、医疗保健和活动监控应用潜力。
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引用次数: 4
A brief review of mechanical designs for additive manufactured soft materials 增材制造软材料的机械设计综述
Pub Date : 2022-01-01 DOI: 10.20517/ss.2021.22
Qiang Zhang, Yan Shi, Zeang Zhao
Additive manufacturing is an arising technology for soft materials and structures with improved complexity and functionality, and it has been gradually widespread in fields including soft robotics, flexible electronics and biomedical devices. Along with the development of material systems and fabrication techniques, mechanical design principles for additive manufactured soft materials were greatly developed and evolved over the past few years, and some special issues that are distinct from conventional manufacturing techniques emerged. In this short review, we mainly focus on additive manufactured soft materials that are in great request of mechanical models/simulations to provide design guidelines, therefore, topics such as soft robotics and electronics are out of scope here. We firstly discuss the mechanical designs for controlling shape distortions and interfacial strength, as they are directly related to the quality and reliability of additive manufactured soft materials. Then, design principles and manufacturing strategies for bio-inspired composites, which makes up a large part of current researches on additive manufactured soft materials, are summarized integrally from three aspects. In addition, basic mechanical considerations for additive manufactured 4D shape changing structures are explained, together with the review of recent theories and numerical approaches. Finally, suggestions and perspectives are given for future developments of soft material additive manufacturing.
增材制造是一项新兴的技术,用于制造复杂和功能性更好的软材料和结构,并逐渐在软机器人、柔性电子和生物医学设备等领域得到广泛应用。随着材料体系和制造技术的发展,增材制造软材料的机械设计原理在过去几年中得到了很大的发展和演变,并出现了一些不同于传统制造技术的特殊问题。在这篇简短的综述中,我们主要关注增材制造的软材料,这些材料对机械模型/仿真有很大的要求,可以提供设计指南,因此,软机器人和电子等主题不在这里讨论范围之内。我们首先讨论了控制形状变形和界面强度的机械设计,因为它们直接关系到增材制造软材料的质量和可靠性。然后,从三个方面对目前增材制造软材料研究中占很大比重的仿生复合材料的设计原则和制造策略进行了综合总结。此外,对增材制造的4D形状变化结构的基本力学考虑进行了解释,并对最近的理论和数值方法进行了回顾。最后,对软材料增材制造的未来发展提出了建议和展望。
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引用次数: 8
Mechanically flexible and flame-retardant cellulose nanofibril-based films integrated with MXene and chitosan 结合MXene和壳聚糖的机械柔性和阻燃的纤维素纳米纤维基薄膜
Pub Date : 2022-01-01 DOI: 10.20517/ss.2022.20
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引用次数: 5
Tattoo-like epidermal electronics as skin sensors for human machine interfaces 纹身状表皮电子学作为人机界面的皮肤传感器
Pub Date : 2021-10-13 DOI: 10.20517/ss.2021.09
T. Wong, Chunki Yiu, Jingkun Zhou, Zhenhao Song, Yiming Liu, Ling Zhao, K. Yao, Woo-Mi Park, Woojung Yoo, E. Song, Zhaoqian Xie, Xinge Yu
Flexible electronic skin (e-skin) has been successfully utilized in diverse applications, including prosthesis sensing, body-motion monitoring and human-machine interfaces, due to its excellent mechanical properties and electrical characteristics. However, current e-skins are still relatively thick (> 10 µ m) and uncomfortable for long-term usage on the human body. Herein, an ultrathin skin-integrated strain sensor with miniaturized dimensions, based on the piezoresistive effect, with excellent stability and robustness, is introduced. The fractal curve-shaped Au electrode in a serpentine format, which is the dominant component of the strain sensor, is sensitive to ambient strain variations and can turn the mechanical motion into a stable electrical signal output. With the advanced design of metallic electrodes, the device presents good operational stability and excellent mechanical tolerance towards bending, stretching and twisting. The stain sensor allows intimate mounting onto the human epidermal surface for the detection of body motion. By adopting a liquid bandage as an encapsulation layer, the device exhibits an ultrathin thickness (6.2 µ m), high sensitivity towards mechanical deformations and capability for the clear
柔性电子皮肤(e-skin)由于其优异的机械性能和电气特性,已成功地应用于假肢传感、身体运动监测和人机界面等多种应用。然而,目前的电子皮肤仍然相对较厚(约10 μ m),长期使用在人体上不舒服。本文介绍了一种基于压阻效应、具有优异稳定性和鲁棒性的小型化尺寸的超薄蒙皮集成应变传感器。蛇形形分形曲线型金电极是应变传感器的主要组成部分,它对环境应变变化敏感,能将机械运动转化为稳定的电信号输出。该装置采用先进的金属电极设计,具有良好的运行稳定性和优异的弯曲、拉伸和扭曲的机械公差。该染色传感器可以亲密地安装在人体表皮表面,以检测身体运动。该器件采用液体绷带作为封装层,具有超薄厚度(6.2µm)、对机械变形的高灵敏度和透明能力
{"title":"Tattoo-like epidermal electronics as skin sensors for human machine interfaces","authors":"T. Wong, Chunki Yiu, Jingkun Zhou, Zhenhao Song, Yiming Liu, Ling Zhao, K. Yao, Woo-Mi Park, Woojung Yoo, E. Song, Zhaoqian Xie, Xinge Yu","doi":"10.20517/ss.2021.09","DOIUrl":"https://doi.org/10.20517/ss.2021.09","url":null,"abstract":"Flexible electronic skin (e-skin) has been successfully utilized in diverse applications, including prosthesis sensing, body-motion monitoring and human-machine interfaces, due to its excellent mechanical properties and electrical characteristics. However, current e-skins are still relatively thick (> 10 µ m) and uncomfortable for long-term usage on the human body. Herein, an ultrathin skin-integrated strain sensor with miniaturized dimensions, based on the piezoresistive effect, with excellent stability and robustness, is introduced. The fractal curve-shaped Au electrode in a serpentine format, which is the dominant component of the strain sensor, is sensitive to ambient strain variations and can turn the mechanical motion into a stable electrical signal output. With the advanced design of metallic electrodes, the device presents good operational stability and excellent mechanical tolerance towards bending, stretching and twisting. The stain sensor allows intimate mounting onto the human epidermal surface for the detection of body motion. By adopting a liquid bandage as an encapsulation layer, the device exhibits an ultrathin thickness (6.2 µ m), high sensitivity towards mechanical deformations and capability for the clear","PeriodicalId":74837,"journal":{"name":"Soft science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45597523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
期刊
Soft science
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