Pub Date : 2025-10-14DOI: 10.1164/rccm.202505-1162vp
Bartolome R Celli,Leonardo M Fabbri,Gerard J Criner,Alberto Papi,Antoni Torres,Alvar Agusti
{"title":"The ROME COPD Exacerbation Proposal Works! Time to Move Forward.","authors":"Bartolome R Celli,Leonardo M Fabbri,Gerard J Criner,Alberto Papi,Antoni Torres,Alvar Agusti","doi":"10.1164/rccm.202505-1162vp","DOIUrl":"https://doi.org/10.1164/rccm.202505-1162vp","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"44 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1164/rccm.202503-0669rl
Joseph B Pryor,Jeffrey J Swigris,Kelsey J Klingel,Sonye K Danoff,Felix A Woodhead,Hilary J Goldberg,Ivan O Rosas,David A Lynch,Stephen M Humphries,Joshua J Solomon
{"title":"Quantitative CT Analysis Reveals Stability of RA-ILD in Patients Treated with Pirfenidone: Insights from the TRAIL1 Trial.","authors":"Joseph B Pryor,Jeffrey J Swigris,Kelsey J Klingel,Sonye K Danoff,Felix A Woodhead,Hilary J Goldberg,Ivan O Rosas,David A Lynch,Stephen M Humphries,Joshua J Solomon","doi":"10.1164/rccm.202503-0669rl","DOIUrl":"https://doi.org/10.1164/rccm.202503-0669rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"13 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1164/rccm.202411-2181rr
Julie C Coursen,Sheila E Enoh,Hannah L Miller,Kristina Montemayor
{"title":"Airway Management Strategies in Critical Care.","authors":"Julie C Coursen,Sheila E Enoh,Hannah L Miller,Kristina Montemayor","doi":"10.1164/rccm.202411-2181rr","DOIUrl":"https://doi.org/10.1164/rccm.202411-2181rr","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"1 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lung Involvement of Myeloid-Lymphoid Neoplasia with Eosinophilia.","authors":"Simone Petrarulo,Sara Piciucchi,Claudio Agostinelli,Stefano Oldani,Alessandra Dubini,Claudia Ravaglia,Venerino Poletti","doi":"10.1164/rccm.202506-1410im","DOIUrl":"https://doi.org/10.1164/rccm.202506-1410im","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"8 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1164/rccm.202501-0288oc
Helen Marshall,Laurie J Smith,Alberto M Biancardi,Guilhem J Collier,Ho-Fung Chan,Paul Jc Hughes,Martin L Brook,Joshua R Astley,Ryan Munro,Smitha Rajaram,Andrew J Swift,David Capener,Jody Bray,James E Ball,Oliver Rodgers,Demi-Jade Jakymelen,Bilal A Tahir,Madhwesha Rao,Graham Norquay,Nicholas D Weatherley,Leanne Armstrong,Latife Hardaker,Alberto Papi,Helen K Reddel,Hana Müllerová,Rod Hughes,Jim M Wild
Rationale: Asthma and chronic obstructive pulmonary disease (COPD) significantly overlap by conventional diagnostic criteria, yet important treatment differences remain, and people with both asthma and COPD ('asthma+COPD') have worse clinical outcomes than people with a single diagnosis. Hyperpolarized xenon-129 magnetic resonance imaging (129Xe MRI) and pulmonary function tests (PFTs) are sensitive to lung function and structure. Objective: To determine whether 129Xe MRI alongside PFTs can aid phenotyping of real-world patients with asthma and/or COPD. Methods: Patients ≥16 years with physician-assigned asthma and/or COPD were recruited from primary care. 129Xe and proton MRI, multiple-breath nitrogen washout, airwave oscillometry, transfer factor of the lung for carbon monoxide (TLco), body plethysmography, and spirometry were assessed post-bronchodilator. Differences between diagnostic groups were assessed. Results: The study assessed 165 patients. 129Xe MRI and PFT metrics differed significantly between diagnostic groups. On 129Xe MRI, patients with COPD had significantly reduced and more heterogeneous ventilation, greater acinar dimensions and lower gas transfer, in addition to lower spirometry, greater airways resistance and reactance, and more air trapping than patients with asthma. Similarly, 129Xe MRI metrics demonstrated greater abnormalities in COPD than asthma when comparing only those with normal forced expiratory volume in 1 second or TLco. Lung function and structure were worse in asthma+COPD than asthma and better than COPD. Conclusions: 129Xe MRI alongside PFTs provide phenotypically distinct airway disease signatures to aid diagnosis of asthma and/or COPD. 129Xe MRI is highly sensitive to minimal lung disease and identifies functional/structural phenotypes that may help to guide treatment decisions.
{"title":"Phenotyping Asthma and/or COPD Using 129Xe MRI and Comprehensive Physiologic Testing.","authors":"Helen Marshall,Laurie J Smith,Alberto M Biancardi,Guilhem J Collier,Ho-Fung Chan,Paul Jc Hughes,Martin L Brook,Joshua R Astley,Ryan Munro,Smitha Rajaram,Andrew J Swift,David Capener,Jody Bray,James E Ball,Oliver Rodgers,Demi-Jade Jakymelen,Bilal A Tahir,Madhwesha Rao,Graham Norquay,Nicholas D Weatherley,Leanne Armstrong,Latife Hardaker,Alberto Papi,Helen K Reddel,Hana Müllerová,Rod Hughes,Jim M Wild","doi":"10.1164/rccm.202501-0288oc","DOIUrl":"https://doi.org/10.1164/rccm.202501-0288oc","url":null,"abstract":"Rationale: Asthma and chronic obstructive pulmonary disease (COPD) significantly overlap by conventional diagnostic criteria, yet important treatment differences remain, and people with both asthma and COPD ('asthma+COPD') have worse clinical outcomes than people with a single diagnosis. Hyperpolarized xenon-129 magnetic resonance imaging (129Xe MRI) and pulmonary function tests (PFTs) are sensitive to lung function and structure. Objective: To determine whether 129Xe MRI alongside PFTs can aid phenotyping of real-world patients with asthma and/or COPD. Methods: Patients ≥16 years with physician-assigned asthma and/or COPD were recruited from primary care. 129Xe and proton MRI, multiple-breath nitrogen washout, airwave oscillometry, transfer factor of the lung for carbon monoxide (TLco), body plethysmography, and spirometry were assessed post-bronchodilator. Differences between diagnostic groups were assessed. Results: The study assessed 165 patients. 129Xe MRI and PFT metrics differed significantly between diagnostic groups. On 129Xe MRI, patients with COPD had significantly reduced and more heterogeneous ventilation, greater acinar dimensions and lower gas transfer, in addition to lower spirometry, greater airways resistance and reactance, and more air trapping than patients with asthma. Similarly, 129Xe MRI metrics demonstrated greater abnormalities in COPD than asthma when comparing only those with normal forced expiratory volume in 1 second or TLco. Lung function and structure were worse in asthma+COPD than asthma and better than COPD. Conclusions: 129Xe MRI alongside PFTs provide phenotypically distinct airway disease signatures to aid diagnosis of asthma and/or COPD. 129Xe MRI is highly sensitive to minimal lung disease and identifies functional/structural phenotypes that may help to guide treatment decisions.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"40 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1164/rccm.202505-1108le
Stavros P Loukogeorgakis,Federica Michielin,Paolo De Coppi
{"title":"Reply to Zeng: VEGF-based Therapy for CDH: A Breakthrough or a Hidden Risk?","authors":"Stavros P Loukogeorgakis,Federica Michielin,Paolo De Coppi","doi":"10.1164/rccm.202505-1108le","DOIUrl":"https://doi.org/10.1164/rccm.202505-1108le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"121 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1164/rccm.202504-0799rl
Fangqi Guo,Elizabeth M Kamai,Sandrah P Eckel,Luis Olmedo,Esther Bejarano,Christian Torres,Christopher Zuidema,Edmund Seto,Shohreh F Farzan,Jill E Johnston
{"title":"Dust Events and Children's Lung Function Near a Drying Saline Lake.","authors":"Fangqi Guo,Elizabeth M Kamai,Sandrah P Eckel,Luis Olmedo,Esther Bejarano,Christian Torres,Christopher Zuidema,Edmund Seto,Shohreh F Farzan,Jill E Johnston","doi":"10.1164/rccm.202504-0799rl","DOIUrl":"https://doi.org/10.1164/rccm.202504-0799rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"18 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1164/rccm.202508-2037ed
Sam Heft-Neal,Carlos F Gould
{"title":"Is a Microgram of Smoke PM2.5 Worse for Respiratory Health? Interpreting New Evidence.","authors":"Sam Heft-Neal,Carlos F Gould","doi":"10.1164/rccm.202508-2037ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-2037ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"122 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Healthcare-associated Family Mental Injury (HILLY).","authors":"Élie Azoulay, Frédéric Pochard, Judith Nelson, Margaret Herridge, Samir Jaber, Nancy Kentish-Barnes","doi":"10.1164/rccm.202501-0313VP","DOIUrl":"https://doi.org/10.1164/rccm.202501-0313VP","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preoperative GLP-1 RA Use and Postoperative Respiratory Complications in Patients Undergoing Elective Surgeries: A Target Trial Emulation Study.","authors":"Pareeta Kotecha,William T Donahoo,Anu Sharma,Naykky Singh Ospina,Ramon Sun,Carl Yang,Jiang Bian,Jingchuan Guo","doi":"10.1164/rccm.202503-0775rl","DOIUrl":"https://doi.org/10.1164/rccm.202503-0775rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"121 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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