Pub Date : 2024-10-29DOI: 10.1164/rccm.202409-1866LE
Marco Giani, Douglas Slobod, Elena Spinelli, Tommaso Mauri
{"title":"Reply to Jha: Cardiopulmonary Effects of Increased Mixed Venous Saturation During Veno-Venous ECMO.","authors":"Marco Giani, Douglas Slobod, Elena Spinelli, Tommaso Mauri","doi":"10.1164/rccm.202409-1866LE","DOIUrl":"https://doi.org/10.1164/rccm.202409-1866LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1164/rccm.202409-1756LE
Ajay Kumar Jha
{"title":"Cardiopulmonary Effects of Increased Mixed Venous Saturation During Veno-Venous ECMO.","authors":"Ajay Kumar Jha","doi":"10.1164/rccm.202409-1756LE","DOIUrl":"https://doi.org/10.1164/rccm.202409-1756LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1164/rccm.202404-0801IM
Andriy Katyukha, Jeffrey M Singh, Hannah Wozniak, Ghislaine Douflé
{"title":"Normalization of Oscillating Flow Pattern on Transcranial Duplex Colour-coded Doppler.","authors":"Andriy Katyukha, Jeffrey M Singh, Hannah Wozniak, Ghislaine Douflé","doi":"10.1164/rccm.202404-0801IM","DOIUrl":"https://doi.org/10.1164/rccm.202404-0801IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-24DOI: 10.1164/rccm.202410-2054st
Tina V Hartert,Kathleen A Hiltz
{"title":"What Is RSV Infection in Adults?","authors":"Tina V Hartert,Kathleen A Hiltz","doi":"10.1164/rccm.202410-2054st","DOIUrl":"https://doi.org/10.1164/rccm.202410-2054st","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"119 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1164/rccm.202311-2184oc
Michael Burnim,Nirupama Putcha,David LaFon,Han Woo,Antoine Azar,Lars Groenke,Martin Stampfli,Alexander Schaub,Ashraf Fawzy,Aparna Balasubramanian,Neal Fedarko,Christopher B Cooper,Russell P Bowler,Alejandro Comellas,Jerry A Krishnan,MeiLan K Han,David Couper,Stephen P Peters,M Bradley Drummond,Wanda O'Neal,Robert Paine,Gerard Criner,Fernando J Martinez,Jeffrey L Curtis,Graham Barr,Yvonne J Huang,Prescott Woodruff,Mark Dransfield,Nadia N Hansel
RATIONALESerum Immunoglobulin G (IgG) deficiency is associated with morbidity in chronic obstructive pulmonary disease (COPD) but it is unclear whether concentrations in the lower end of the normal range still confer risk.OBJECTIVESTo determine if levels above traditional cutoffs for serum IgG deficiency are associated with exacerbations among current and former smokers with or at risk for COPD.MEASUREMENTS AND MAIN RESULTSFormer and current smokers in SPIROMICS (n=1,497) were studied, n=1,026 with and n=471 at risk for COPD. In a subset (n=1,031), IgG subclasses were measured. Associations between total IgG or subclasses and prospective exacerbations were evaluated with multivariable models adjusting for demographics, current smoking, smoking history, FEV1% predicted, inhaled corticosteroids, and serum IgA.RESULTSThe 35th percentile (1225 mg/dL in this cohort) of IgG was the best cutoff by Akaike Information Criterion (AIC). Below this, there was increased exacerbation risk (IRR 1.28, 95% CI 1.08-1.51). Among subclasses, IgG1 and IgG2 below 35th percentile (354 and 105 mg/dL, respectively) were both associated with increased risk of severe exacerbation (IgG1: IRR 1.39, 95% CI 1.06-1.84; IgG2: IRR 1.50, 95% CI 1.14-1.1.97). These associations remained significant when additionally adjusting for history of exacerbations.CONCLUSIONSLower serum IgG is prospectively associated with exacerbations in individuals with or at risk for COPD. Among subclasses, lower IgG1 and IgG2 are prospectively associated with severe exacerbations. The optimal IgG cutoff was substantially higher than traditional cutoffs for deficiency, suggesting subtle impairment of humoral immunity may be associated with exacerbations.
理论依据血清免疫球蛋白 G (IgG) 缺乏与慢性阻塞性肺病 (COPD) 的发病率有关，但尚不清楚正常范围下限的浓度是否仍会带来风险。测量和主要结果研究了 SPIROMICS（n=1,497）中的吸烟者（n=1,026）和有慢性阻塞性肺病风险的吸烟者（n=471）。在一个子集（n=1,031）中，对 IgG 亚类进行了测量。通过多变量模型评估了总 IgG 或亚类与前瞻性病情加重之间的关系，并对人口统计学、目前吸烟情况、吸烟史、预测 FEV1%、吸入皮质类固醇和血清 IgA 进行了调整。结果IgG 的第 35 百分位数（该队列中为 1225 mg/dL）是阿凯克信息标准 (Akaike Information Criterion, AIC) 的最佳临界值。低于此值，病情恶化风险增加（IRR 1.28，95% CI 1.08-1.51）。在亚类别中，IgG1 和 IgG2 低于第 35 百分位数（分别为 354 和 105 mg/dL）均与严重病情恶化风险增加有关（IgG1：IRR 1.39，95% CI 1.06-1.84；IgG2：IRR 1.50，95% CI 1.14-1.1.97）。结论在慢性阻塞性肺病患者或高危人群中，血清 IgG 较低与病情恶化前瞻性相关。在亚类中，较低的 IgG1 和 IgG2 可能与严重的病情加重有关。最佳的 IgG 临界值远高于传统的缺乏临界值，这表明体液免疫的细微损伤可能与病情加重有关。
{"title":"Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.","authors":"Michael Burnim,Nirupama Putcha,David LaFon,Han Woo,Antoine Azar,Lars Groenke,Martin Stampfli,Alexander Schaub,Ashraf Fawzy,Aparna Balasubramanian,Neal Fedarko,Christopher B Cooper,Russell P Bowler,Alejandro Comellas,Jerry A Krishnan,MeiLan K Han,David Couper,Stephen P Peters,M Bradley Drummond,Wanda O'Neal,Robert Paine,Gerard Criner,Fernando J Martinez,Jeffrey L Curtis,Graham Barr,Yvonne J Huang,Prescott Woodruff,Mark Dransfield,Nadia N Hansel","doi":"10.1164/rccm.202311-2184oc","DOIUrl":"https://doi.org/10.1164/rccm.202311-2184oc","url":null,"abstract":"RATIONALESerum Immunoglobulin G (IgG) deficiency is associated with morbidity in chronic obstructive pulmonary disease (COPD) but it is unclear whether concentrations in the lower end of the normal range still confer risk.OBJECTIVESTo determine if levels above traditional cutoffs for serum IgG deficiency are associated with exacerbations among current and former smokers with or at risk for COPD.MEASUREMENTS AND MAIN RESULTSFormer and current smokers in SPIROMICS (n=1,497) were studied, n=1,026 with and n=471 at risk for COPD. In a subset (n=1,031), IgG subclasses were measured. Associations between total IgG or subclasses and prospective exacerbations were evaluated with multivariable models adjusting for demographics, current smoking, smoking history, FEV1% predicted, inhaled corticosteroids, and serum IgA.RESULTSThe 35th percentile (1225 mg/dL in this cohort) of IgG was the best cutoff by Akaike Information Criterion (AIC). Below this, there was increased exacerbation risk (IRR 1.28, 95% CI 1.08-1.51). Among subclasses, IgG1 and IgG2 below 35th percentile (354 and 105 mg/dL, respectively) were both associated with increased risk of severe exacerbation (IgG1: IRR 1.39, 95% CI 1.06-1.84; IgG2: IRR 1.50, 95% CI 1.14-1.1.97). These associations remained significant when additionally adjusting for history of exacerbations.CONCLUSIONSLower serum IgG is prospectively associated with exacerbations in individuals with or at risk for COPD. Among subclasses, lower IgG1 and IgG2 are prospectively associated with severe exacerbations. The optimal IgG cutoff was substantially higher than traditional cutoffs for deficiency, suggesting subtle impairment of humoral immunity may be associated with exacerbations.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"234 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1164/rccm.202402-0306im
Don Hayes
{"title":"Resolution of Acute Lung Allograft Rejection Detected by Probe-based Confocal Laser Endomicroscopy.","authors":"Don Hayes","doi":"10.1164/rccm.202402-0306im","DOIUrl":"https://doi.org/10.1164/rccm.202402-0306im","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"23 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-23DOI: 10.1164/rccm.202309-1594oc
Sairam Parthasarathy,Christopher Wendel,Michael A Grandner,Patricia L Haynes,Stefano Guerra,Daniel Combs,Stuart F Quan
RATIONALEObstructive sleep apnea (OSA) is a common condition that is usually treated by continuous positive airway pressure (CPAP) therapy, but poor adherence is common and is associated with worse patient outcomes and experiences. Patient satisfaction is increasingly adopted as a quality indicator by healthcare systems.OBJECTIVEWe tested the hypothesis that peer-driven intervention effected through interactive voice-response(PDI-IVR) system leads to better patient satisfaction (primary outcome), care-coordination, and CPAP adherence when compared to active-control.METHODSWe performed a 6-month randomized, parallel-group, controlled trial with CPAP naïve patients recruited from four centers and CPAP-adherent patients who were trained to be mentors delivering support through an IVR system.MEASUREMENTS AND RESULTSIn 263 patients, intention-to-treat analysis global satisfaction for sleep-specific services was better in the intervention group (4.57+0.71 Likert scale score) than in the active-control group (4.10+1.13; P<0.001). CPAP adherence was greater in intervention group (4.5+0.2 hours/night; 62.0+3.0% of nights >4 hours usage) versus active-control group (3.7+0.2 hours/night; 51.4+3.0% of nights >4 hours usage; P=0.014 and P=0.023). When compared to active-control group, Patient Assessment of Chronic Illness Care ratings was moderately increased by an adjusted difference of 0.33+0.12 (P=0.009); Consumer Assessment of Healthcare Provider and Systems ratings was not different (adjusted difference of 0.46+0.26; P=0.076); and Client Perception of Coordination Questionnaire was mildly better in the intervention group (adjusted difference 0.15+0.07; P=0.035).CONCLUSIONPatient satisfaction with care delivery, CPAP adherence, and care-coordination was improved by peer-driven intervention through an IVR system. New payor policies compensating peer-support may enable implementation of this approach. Clinical trial registration available at www.CLINICALTRIALSgov, ID: NCT02056002.
{"title":"Peer-Driven Intervention for Care Coordination and Adherence Promotion for Obstructive Sleep Apnea: A Randomized, Parallel-Group Clinical Trial.","authors":"Sairam Parthasarathy,Christopher Wendel,Michael A Grandner,Patricia L Haynes,Stefano Guerra,Daniel Combs,Stuart F Quan","doi":"10.1164/rccm.202309-1594oc","DOIUrl":"https://doi.org/10.1164/rccm.202309-1594oc","url":null,"abstract":"RATIONALEObstructive sleep apnea (OSA) is a common condition that is usually treated by continuous positive airway pressure (CPAP) therapy, but poor adherence is common and is associated with worse patient outcomes and experiences. Patient satisfaction is increasingly adopted as a quality indicator by healthcare systems.OBJECTIVEWe tested the hypothesis that peer-driven intervention effected through interactive voice-response(PDI-IVR) system leads to better patient satisfaction (primary outcome), care-coordination, and CPAP adherence when compared to active-control.METHODSWe performed a 6-month randomized, parallel-group, controlled trial with CPAP naïve patients recruited from four centers and CPAP-adherent patients who were trained to be mentors delivering support through an IVR system.MEASUREMENTS AND RESULTSIn 263 patients, intention-to-treat analysis global satisfaction for sleep-specific services was better in the intervention group (4.57+0.71 Likert scale score) than in the active-control group (4.10+1.13; P<0.001). CPAP adherence was greater in intervention group (4.5+0.2 hours/night; 62.0+3.0% of nights >4 hours usage) versus active-control group (3.7+0.2 hours/night; 51.4+3.0% of nights >4 hours usage; P=0.014 and P=0.023). When compared to active-control group, Patient Assessment of Chronic Illness Care ratings was moderately increased by an adjusted difference of 0.33+0.12 (P=0.009); Consumer Assessment of Healthcare Provider and Systems ratings was not different (adjusted difference of 0.46+0.26; P=0.076); and Client Perception of Coordination Questionnaire was mildly better in the intervention group (adjusted difference 0.15+0.07; P=0.035).CONCLUSIONPatient satisfaction with care delivery, CPAP adherence, and care-coordination was improved by peer-driven intervention through an IVR system. New payor policies compensating peer-support may enable implementation of this approach. Clinical trial registration available at www.CLINICALTRIALSgov, ID: NCT02056002.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"63 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1164/rccm.202406-1121rl
Andreas Perikleous,Sarah-Jane Bowen,Chris Griffiths,Ian Pavord,Mark Rosenthal,Louise Fleming,Andrew Bush
{"title":"Blood Eosinophil Count: Lack of Stability and Association with Wheeze Attacks in Preschool Children.","authors":"Andreas Perikleous,Sarah-Jane Bowen,Chris Griffiths,Ian Pavord,Mark Rosenthal,Louise Fleming,Andrew Bush","doi":"10.1164/rccm.202406-1121rl","DOIUrl":"https://doi.org/10.1164/rccm.202406-1121rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"861 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1164/rccm.202404-0843oc
Ignacio Oulego-Erroz,María Del Pilar De Castro-Vecino,Rafael González-Cortés,Almudena Alonso-Ojembarrena,Antonio Rodríguez-Nuñez,Daniel Palanca-Arias,Úrsula Quesada-Ortega,Sonia Sanchiz-Cardenas,María Ángeles Murillo-Pozo,Jorge López-González,Pilar Sánchez-Yáñez,Juan Valencia-Ramos,Andrea Fernández-de la Ballina,Nuria Chaves-Caro,Raúl Borrego-Domínguez,María Sánchez-Porras,Manuel Rodríguez-Martínez,Pedro José Carballo-Martín,Lorena Bermúdez-Barrezueta,Javier Rodríguez-Fanjul,Ana Vivanco-Allende,Patricia Rodríguez-Campoy,Laia Vega-Puyal,Javier Gil-Antón,Idoia Sánchez-Martínez,Olivia Pérez-Quevedo,Marta Muñoyerro-Sesmero,Luisa Barón-González de Suso,Juan Mayordomo-Colunga
RATIONALELung ultrasound may be useful for prognostication of acute lung disease.OBJECTIVESTo assess whether the lung ultrasound score is associated with the severity of lung disease and may predict prolonged invasive mechanical ventilation in critically ill children.METHODSProspective observational multicenter study in children aged 1 month to 18 years who required respiratory support in the intensive care unit. Children with chronic parenchymal lung disease were excluded. The lung ultrasound score was obtained at 12 hours and 48-72 hours from admission. Prolonged invasive mechanical ventilation was defined as >7 consecutive days. Correlation of the lung ultrasound score with oxygenation as well as its prognostic accuracy for prolonged invasive mechanical ventilation were investigated.RESULTS538 children were included and 62 (11.5%) required prolonged mechanical ventilation. In these subjects, the lung ultrasound score was higher at 12 [24 (19-26) vs. 8 (3-14); p<0.001] and 48-72 hours [16 (10.5-22.5) vs. 6 (3-11) vs; p<0.001]. At 12 hours the lung ultrasound score correlated with oxygenation index [R2= 0.435 (95% CI: 0.293-0.566), rho coefficient -0.705, p<0.001] and oxygen saturation index [R2 0.499 (95% CI: 0.370-0.613), rho coefficient 0.651, p<0.001p<0.001]. To predict prolonged invasive mechanical ventilation, the lung ultrasound score at 12 hours had a good accuracy [AUROC=0.87 (95% CI: 0.81-0.93)] while its use in a multivariable model had an excellent accuracy both in derivation [AUROC=0.92 (95% CI: 0.89-0.95)] and internal validation [AUROC=0.91 (95% CI: 0.90-0.92)].CONCLUSIONIn critically ill children, the lung ultrasound score early after admission may predict prolonged invasive mechanical ventilation.
{"title":"Lung Ultrasound Score, Severity of Acute Lung Disease and Prolonged Mechanical Ventilation in Children.","authors":"Ignacio Oulego-Erroz,María Del Pilar De Castro-Vecino,Rafael González-Cortés,Almudena Alonso-Ojembarrena,Antonio Rodríguez-Nuñez,Daniel Palanca-Arias,Úrsula Quesada-Ortega,Sonia Sanchiz-Cardenas,María Ángeles Murillo-Pozo,Jorge López-González,Pilar Sánchez-Yáñez,Juan Valencia-Ramos,Andrea Fernández-de la Ballina,Nuria Chaves-Caro,Raúl Borrego-Domínguez,María Sánchez-Porras,Manuel Rodríguez-Martínez,Pedro José Carballo-Martín,Lorena Bermúdez-Barrezueta,Javier Rodríguez-Fanjul,Ana Vivanco-Allende,Patricia Rodríguez-Campoy,Laia Vega-Puyal,Javier Gil-Antón,Idoia Sánchez-Martínez,Olivia Pérez-Quevedo,Marta Muñoyerro-Sesmero,Luisa Barón-González de Suso,Juan Mayordomo-Colunga","doi":"10.1164/rccm.202404-0843oc","DOIUrl":"https://doi.org/10.1164/rccm.202404-0843oc","url":null,"abstract":"RATIONALELung ultrasound may be useful for prognostication of acute lung disease.OBJECTIVESTo assess whether the lung ultrasound score is associated with the severity of lung disease and may predict prolonged invasive mechanical ventilation in critically ill children.METHODSProspective observational multicenter study in children aged 1 month to 18 years who required respiratory support in the intensive care unit. Children with chronic parenchymal lung disease were excluded. The lung ultrasound score was obtained at 12 hours and 48-72 hours from admission. Prolonged invasive mechanical ventilation was defined as >7 consecutive days. Correlation of the lung ultrasound score with oxygenation as well as its prognostic accuracy for prolonged invasive mechanical ventilation were investigated.RESULTS538 children were included and 62 (11.5%) required prolonged mechanical ventilation. In these subjects, the lung ultrasound score was higher at 12 [24 (19-26) vs. 8 (3-14); p<0.001] and 48-72 hours [16 (10.5-22.5) vs. 6 (3-11) vs; p<0.001]. At 12 hours the lung ultrasound score correlated with oxygenation index [R2= 0.435 (95% CI: 0.293-0.566), rho coefficient -0.705, p<0.001] and oxygen saturation index [R2 0.499 (95% CI: 0.370-0.613), rho coefficient 0.651, p<0.001p<0.001]. To predict prolonged invasive mechanical ventilation, the lung ultrasound score at 12 hours had a good accuracy [AUROC=0.87 (95% CI: 0.81-0.93)] while its use in a multivariable model had an excellent accuracy both in derivation [AUROC=0.92 (95% CI: 0.89-0.95)] and internal validation [AUROC=0.91 (95% CI: 0.90-0.92)].CONCLUSIONIn critically ill children, the lung ultrasound score early after admission may predict prolonged invasive mechanical ventilation.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"11 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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