Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.012
Utari ., dan Erni Rustiani
Please cite this article as: Utari et al., Liquid Herbal Mixed of Indian Borage Extract and Tamarind Flesh As Anti-diabetes. American Journal of PharmTech Research 2019. Liquid Herbal Mixed of Indian Borage Extract and Tamarind Flesh As Anti-diabetes Utari dan Erni Rustiani Pharmacy Study Program, Mathematics & Sciences Faculty, Pakuan University, Bogor ABSTRACT Indian borage leaves (Coleus amboinicus) at dose of 620mg/KgBB and tamarind (Tamarindus indica) at dose of 300mg/KgBB effectively decrease glucose contain in blood with work mechanism by reducing oxidative stress in body. Flavonoid contain in these plants was thought to play role as anti-diabetes. Because of the efficacy similarity of these plants, so the combination of Indian borage and tamarind extract was made in liquid herbal dosage form. The liquid herbal in this research were intended to oral use, so they can be given additional flavoring, sweetener, or watersoluble dyes to improve dosage quality. Liquid herbal dosage were made in 4 formulas based on different types of sweeteners, the test result showed that liquid herbal with palm sugar sweetener was the most preferred by panellists. Selected formulas from the test of preference was tested for quality testing include : stabilization test at three different temperatures over a period of 8 weeks with parameters pH measuring, viscosity, specific gravity, organoleptic, determination of flavonoid content and testing of microbial contamination. Stability test result showed a change in the quality and decrease in flavonoid levels in liquid herbals dosage every week. Based on data on the decrease in flavonoid contain in stability test, the prediction of the shelf life of liquid herbals dosage was obtained for 8 week at room temperature.
{"title":"Liquid Herbal Mixed of Indian Borage Extract and Tamarind Flesh As Anti-diabetes","authors":"Utari ., dan Erni Rustiani","doi":"10.46624/ajptr.2020.v10.i3.012","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.012","url":null,"abstract":"Please cite this article as: Utari et al., Liquid Herbal Mixed of Indian Borage Extract and Tamarind Flesh As Anti-diabetes. American Journal of PharmTech Research 2019. Liquid Herbal Mixed of Indian Borage Extract and Tamarind Flesh As Anti-diabetes Utari dan Erni Rustiani Pharmacy Study Program, Mathematics & Sciences Faculty, Pakuan University, Bogor ABSTRACT Indian borage leaves (Coleus amboinicus) at dose of 620mg/KgBB and tamarind (Tamarindus indica) at dose of 300mg/KgBB effectively decrease glucose contain in blood with work mechanism by reducing oxidative stress in body. Flavonoid contain in these plants was thought to play role as anti-diabetes. Because of the efficacy similarity of these plants, so the combination of Indian borage and tamarind extract was made in liquid herbal dosage form. The liquid herbal in this research were intended to oral use, so they can be given additional flavoring, sweetener, or watersoluble dyes to improve dosage quality. Liquid herbal dosage were made in 4 formulas based on different types of sweeteners, the test result showed that liquid herbal with palm sugar sweetener was the most preferred by panellists. Selected formulas from the test of preference was tested for quality testing include : stabilization test at three different temperatures over a period of 8 weeks with parameters pH measuring, viscosity, specific gravity, organoleptic, determination of flavonoid content and testing of microbial contamination. Stability test result showed a change in the quality and decrease in flavonoid levels in liquid herbals dosage every week. Based on data on the decrease in flavonoid contain in stability test, the prediction of the shelf life of liquid herbals dosage was obtained for 8 week at room temperature.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73597449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.001
Usha Veerachari, Bopaiah Ak, S. U, Jyothi Sg, Somashekariah Bv, Ravikanth G
Please cite this article as: Veerachari U et al., Anti-oxidative activity of Cassia L. species of Southern India. American Journal of PharmTech Research 2019. Anti-oxidative activity of Cassia L. species of Southern India Usha Veerachari*, Bopaiah AK, Senthilkumar U, Jyothi SG, Somashekariah BV, Ravikanth G. 1.Department of Life Sciences, Jain University, Bengaluru-560027, India. 2.Department of Botany, St. Joseph’s College PG and Research Centre, Bengaluru560027, India. 3.Ashoka Trust for Research in Ecology and the Environment, Srirampura, Jakkur Post, Bengaluru-560064, India. 4.School of Ecology and Conservation, University of Agricultural Sciences, GKVK, Bengaluru560065, India. 5. Department of Biochemistry, BMS College for Women, Bengaluru-560004, India. ABSTRACT To establish a comparative account within the taxa by assessing its anti-oxidative property and mapping it with the morphometric characters. The methanolic leaf extracts of 12 Cassia L. species were screened for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and reducing power capability with reference to standard Ascorbic acid. Chamaecrista kleinii exhibited strong antioxidant activity with IC50 2.17 μg mL, followed with Senna auriculata (IC50 11.51 μg mL ) and Senna polyphylla (15.17 μg mL). Highest reducing ability was observed in Senna auriculata extract with 0.676 nm absorbance. The correlation observed between the reducing power and DPPH radical scavenging assay supports the contribution of the phytoconstitutents like phenolics and flavonoids towards managing oxidative stress. The present study reveals the beneficiary effects of the selected plants by virtue of their antioxidant activity that can be harnessed in drug formulations.
{"title":"Anti-oxidative activity of Cassia L. species of Southern India","authors":"Usha Veerachari, Bopaiah Ak, S. U, Jyothi Sg, Somashekariah Bv, Ravikanth G","doi":"10.46624/ajptr.2020.v10.i3.001","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.001","url":null,"abstract":"Please cite this article as: Veerachari U et al., Anti-oxidative activity of Cassia L. species of Southern India. American Journal of PharmTech Research 2019. Anti-oxidative activity of Cassia L. species of Southern India Usha Veerachari*, Bopaiah AK, Senthilkumar U, Jyothi SG, Somashekariah BV, Ravikanth G. 1.Department of Life Sciences, Jain University, Bengaluru-560027, India. 2.Department of Botany, St. Joseph’s College PG and Research Centre, Bengaluru560027, India. 3.Ashoka Trust for Research in Ecology and the Environment, Srirampura, Jakkur Post, Bengaluru-560064, India. 4.School of Ecology and Conservation, University of Agricultural Sciences, GKVK, Bengaluru560065, India. 5. Department of Biochemistry, BMS College for Women, Bengaluru-560004, India. ABSTRACT To establish a comparative account within the taxa by assessing its anti-oxidative property and mapping it with the morphometric characters. The methanolic leaf extracts of 12 Cassia L. species were screened for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and reducing power capability with reference to standard Ascorbic acid. Chamaecrista kleinii exhibited strong antioxidant activity with IC50 2.17 μg mL, followed with Senna auriculata (IC50 11.51 μg mL ) and Senna polyphylla (15.17 μg mL). Highest reducing ability was observed in Senna auriculata extract with 0.676 nm absorbance. The correlation observed between the reducing power and DPPH radical scavenging assay supports the contribution of the phytoconstitutents like phenolics and flavonoids towards managing oxidative stress. The present study reveals the beneficiary effects of the selected plants by virtue of their antioxidant activity that can be harnessed in drug formulations.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85096344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2019.v9.i4.014
Saripadiya Nimesh D, D. M. M. Patel
Skin cancer remains the second most common cancer causing death in majority of the population worldwide.” Chemotherapeutical treatment generally includes treatment by administration of chemotherapeutical formulations mostly by intravenous route of administration which is painful, toxic, time consuming and costly for the patients. Chemotherapy also causes toxicity and cell death to other normal cells in the body apart from cancerous cells. The aim of the present investigation was to formulate a topical nano-particulate drug delivery system which causes lower exposure to normal body cells by higher efficacy of targeting the cancerous cells, producing lower toxicity rates and avoiding maximum possible side effects.” “Henceforth, an anti-neoplastic agent has been used in order to prepare Nano-structured Lipid Carriers (NLCs) which was further loaded into gel formulation for topical application. “The nano-structured lipid carrier (NLCs) of 5-fluorouracil (5-FU) were prepared by using Compritol ATO 888 by double emulsification method.” The lipids were selected based on the solubility studies and partition coefficient of 5-FU in lipids. The particle size of optimized formulation was found to be 246.2nm. The in vitro release studies of developed NLCs was carriers carried out at pH 7.4. Sodium carboxy methylcellulose, hydroxyl propyl methyl cellulose , and chitosan hydrogels loaded with NLCs were developed. The permeability behavior through dialysis membrane was performed for 24 hrs and Q 24 of optimized gel formulation was found to be 435.974µg/cm 2 .The steady-state flux (Jss) was found to be 0.062102 mg/cm 2 , and permeability coefficient (Kp) was found to be 4.14013 cm/hr for optimized NLCs based gel formulation for ex-vivo skin permeability studies.
{"title":"Preparation and Evaluation of 5-Florouracil loaded Nano-Structured lipid carrier by double emulsification techniques","authors":"Saripadiya Nimesh D, D. M. M. Patel","doi":"10.46624/ajptr.2019.v9.i4.014","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i4.014","url":null,"abstract":"Skin cancer remains the second most common cancer causing death in majority of the population worldwide.” Chemotherapeutical treatment generally includes treatment by administration of chemotherapeutical formulations mostly by intravenous route of administration which is painful, toxic, time consuming and costly for the patients. Chemotherapy also causes toxicity and cell death to other normal cells in the body apart from cancerous cells. The aim of the present investigation was to formulate a topical nano-particulate drug delivery system which causes lower exposure to normal body cells by higher efficacy of targeting the cancerous cells, producing lower toxicity rates and avoiding maximum possible side effects.” “Henceforth, an anti-neoplastic agent has been used in order to prepare Nano-structured Lipid Carriers (NLCs) which was further loaded into gel formulation for topical application. “The nano-structured lipid carrier (NLCs) of 5-fluorouracil (5-FU) were prepared by using Compritol ATO 888 by double emulsification method.” The lipids were selected based on the solubility studies and partition coefficient of 5-FU in lipids. The particle size of optimized formulation was found to be 246.2nm. The in vitro release studies of developed NLCs was carriers carried out at pH 7.4. Sodium carboxy methylcellulose, hydroxyl propyl methyl cellulose , and chitosan hydrogels loaded with NLCs were developed. The permeability behavior through dialysis membrane was performed for 24 hrs and Q 24 of optimized gel formulation was found to be 435.974µg/cm 2 .The steady-state flux (Jss) was found to be 0.062102 mg/cm 2 , and permeability coefficient (Kp) was found to be 4.14013 cm/hr for optimized NLCs based gel formulation for ex-vivo skin permeability studies.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73115395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2019.v9.i4.017
Y. Raut, A. Dubey
Please cite this article as: Raut YB et al., Formulation and Evaluation of Levetiracetam Matrix Tablet Using Polyethylene Oxides. American Journal of PharmTech Research 2019. Formulation and Evaluation of Levetiracetam Matrix Tablet Using Polyethylene Oxides Y.B Raut*, A.S. Dubey 1.Department of Pharmaceutics, Gawande College of pharmacy, Sakharkherda-443201, Dist. Buldana, Maharashtra 2.Department of Pharmaceutics, CSM University, Kanpur, U.P ABSTRACT The objective of work was to prepare and characterize Levetiracetam matrix tablet using Polyethylene oxides (PEO 301, PEO coagulant and PEO 303) by wet granulation technique using variable concentrations of PEO 301, PEO coagulant and PEO 303. Total 12 formulations were prepared and optimized formulation were evaluated by Differential scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and The results obtained showed that the formulations of Levetiracetam prepared with combination PEO 303 (T10) has controlled release over 12 hrs.
{"title":"Formulation and Evaluation of Levetiracetam Matrix Tablet Using Polyethylene Oxides","authors":"Y. Raut, A. Dubey","doi":"10.46624/ajptr.2019.v9.i4.017","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i4.017","url":null,"abstract":"Please cite this article as: Raut YB et al., Formulation and Evaluation of Levetiracetam Matrix Tablet Using Polyethylene Oxides. American Journal of PharmTech Research 2019. Formulation and Evaluation of Levetiracetam Matrix Tablet Using Polyethylene Oxides Y.B Raut*, A.S. Dubey 1.Department of Pharmaceutics, Gawande College of pharmacy, Sakharkherda-443201, Dist. Buldana, Maharashtra 2.Department of Pharmaceutics, CSM University, Kanpur, U.P ABSTRACT The objective of work was to prepare and characterize Levetiracetam matrix tablet using Polyethylene oxides (PEO 301, PEO coagulant and PEO 303) by wet granulation technique using variable concentrations of PEO 301, PEO coagulant and PEO 303. Total 12 formulations were prepared and optimized formulation were evaluated by Differential scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and The results obtained showed that the formulations of Levetiracetam prepared with combination PEO 303 (T10) has controlled release over 12 hrs.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89439916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.016
Elena Mallia, Dr Claire Shoemake
Elena Mallia*, Dr Claire Shoemake University of Malta ABSTRACT Staurosporine is a naturally occurring alkaloid isolated from the bacterium Streptomyces staurosporesa. It inhibits the protein kinases class of enzymes (including protein kinase C) inducing apoptosis and thus resulting in it having potential anti-tumour activity. Recent studies showed that staurosporine had high affinity for the protein kinase C receptor, however lacked selectivity resulting in a wide adverse effect profile. Thus, this study targets the protein kinase C receptor for the development of novel structures capable of its inhibition using staurosporine as template molecule. This study has yielded two molecular cohorts, one from each approach. These were filtered for Lipinski Rule compliance and segregated into families of pharmacophoric similarity and ranked in order of affinity. The molecules with the best ligand binding affinities were generated using the de novo approach. The best molecule from the de novo approach had an affinity of 10, while the best molecule from the virtual screening approach had an affinity of 9.65. This study was valuable in demonstrating that the staurosporine scaffold was suitable for the identification and design of high affinity structures capable of modulating the protein kinase C receptor through two distinct approachesde novo design and virtual screening. The affinities of the optimal molecules exceeded that of stautosporine, and these molecules will be proposed for further study. Specifically, their enhanced molecular interactions will be explained from an atomic perspective, and also through molecular dynamic simulation studies.
{"title":"Design of Novel Protein Kinase Inhibitors Using the Naturally Occurring Staurosporine Scaffold as a Lead","authors":"Elena Mallia, Dr Claire Shoemake","doi":"10.46624/ajptr.2020.v10.i3.016","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.016","url":null,"abstract":"Elena Mallia*, Dr Claire Shoemake University of Malta ABSTRACT Staurosporine is a naturally occurring alkaloid isolated from the bacterium Streptomyces staurosporesa. It inhibits the protein kinases class of enzymes (including protein kinase C) inducing apoptosis and thus resulting in it having potential anti-tumour activity. Recent studies showed that staurosporine had high affinity for the protein kinase C receptor, however lacked selectivity resulting in a wide adverse effect profile. Thus, this study targets the protein kinase C receptor for the development of novel structures capable of its inhibition using staurosporine as template molecule. This study has yielded two molecular cohorts, one from each approach. These were filtered for Lipinski Rule compliance and segregated into families of pharmacophoric similarity and ranked in order of affinity. The molecules with the best ligand binding affinities were generated using the de novo approach. The best molecule from the de novo approach had an affinity of 10, while the best molecule from the virtual screening approach had an affinity of 9.65. This study was valuable in demonstrating that the staurosporine scaffold was suitable for the identification and design of high affinity structures capable of modulating the protein kinase C receptor through two distinct approachesde novo design and virtual screening. The affinities of the optimal molecules exceeded that of stautosporine, and these molecules will be proposed for further study. Specifically, their enhanced molecular interactions will be explained from an atomic perspective, and also through molecular dynamic simulation studies.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83246181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.010
K. Bhavyasri, R. Sai Chandana, M. Sumakanth, R. Swethasri
Please cite this article as: Bhavyasri K et al., Analytical Method Development and Validation for The Estimation of Pioglitazone Hydrochloride in Bulk and Formulation by UV-Spectrophotometry. American Journal of PharmTech Research 2019. Analytical Method Development and Validation for The Estimation of Pioglitazone Hydrochloride in Bulk and Formulation by UVSpectrophotometry K. Bhavyasri *, R. Sai Chandana, M. Sumakanth, R. Swethasri 1.RBVRRWomen’s College of Pharmacy Barkatpura, Hyderabad500027, India ABSTRACT The present work deals with the development of reliable method for the estimation of pioglitazone hydrochloride by using UV spectroscopy. The pioglitazone hydrochloride showed absorption maxima at wavelength 268nm respectively. The linearity range for pioglitazone hydrochloride was in the range of 10-50μg/ml with correlation coefficient of 0.999. The precision was carried out for pioglitazone hydrochloride and value was found to be less than 2. The proposed method’s results were found satisfactory and are suitable for determination of pioglitazone hydrochloride for routine quality control of drug in bulk and formulation. This method is validated according to ICH guidelines Q2R1.
{"title":"Analytical Method Development and Validation for The Estimation of Pioglitazone Hydrochloride in Bulk and Formulation by UV-Spectrophotometry","authors":"K. Bhavyasri, R. Sai Chandana, M. Sumakanth, R. Swethasri","doi":"10.46624/ajptr.2020.v10.i3.010","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.010","url":null,"abstract":"Please cite this article as: Bhavyasri K et al., Analytical Method Development and Validation for The Estimation of Pioglitazone Hydrochloride in Bulk and Formulation by UV-Spectrophotometry. American Journal of PharmTech Research 2019. Analytical Method Development and Validation for The Estimation of Pioglitazone Hydrochloride in Bulk and Formulation by UVSpectrophotometry K. Bhavyasri *, R. Sai Chandana, M. Sumakanth, R. Swethasri 1.RBVRRWomen’s College of Pharmacy Barkatpura, Hyderabad500027, India ABSTRACT The present work deals with the development of reliable method for the estimation of pioglitazone hydrochloride by using UV spectroscopy. The pioglitazone hydrochloride showed absorption maxima at wavelength 268nm respectively. The linearity range for pioglitazone hydrochloride was in the range of 10-50μg/ml with correlation coefficient of 0.999. The precision was carried out for pioglitazone hydrochloride and value was found to be less than 2. The proposed method’s results were found satisfactory and are suitable for determination of pioglitazone hydrochloride for routine quality control of drug in bulk and formulation. This method is validated according to ICH guidelines Q2R1.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84607461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.006
C.Murali Krishna Goud, Y. Sravani
A Pulsatile drug delivery system delivers drug in rapid and burst manner within a short time after a lag time. There are many situations where drug is needed to be released immediately (after bursting the delaying film coat) at specific site. The aim of present work is to develop Pulsatile drug delivery of Tiotropium Bromide using press coating method. All the formulations have shown satisfactory results for various physicochemical parameters like hardness, friability, thickness, weight variation. Ethyl cellulose has predominant effect on the lag time, while also shows significant effect on drug release. Press coated tablet shows a delayed release pattern. Among all the core tablet formulations T7 was selected based on drug release within a given period of time. In-vitro release rate studies showed that the P3T7 was optimized based on less amount of drug release during lag time. Formulations P3T7 found to be stable at 45 C and 75% RH for a period of 6 months. FT-IR studies revealed that there was no interaction between Tiotropium bromide and the polymers.
{"title":"Formulation Development of Pulsatile Drug Delivery of Tiotropium Bromide","authors":"C.Murali Krishna Goud, Y. Sravani","doi":"10.46624/ajptr.2020.v10.i3.006","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.006","url":null,"abstract":"A Pulsatile drug delivery system delivers drug in rapid and burst manner within a short time after a lag time. There are many situations where drug is needed to be released immediately (after bursting the delaying film coat) at specific site. The aim of present work is to develop Pulsatile drug delivery of Tiotropium Bromide using press coating method. All the formulations have shown satisfactory results for various physicochemical parameters like hardness, friability, thickness, weight variation. Ethyl cellulose has predominant effect on the lag time, while also shows significant effect on drug release. Press coated tablet shows a delayed release pattern. Among all the core tablet formulations T7 was selected based on drug release within a given period of time. In-vitro release rate studies showed that the P3T7 was optimized based on less amount of drug release during lag time. Formulations P3T7 found to be stable at 45 C and 75% RH for a period of 6 months. FT-IR studies revealed that there was no interaction between Tiotropium bromide and the polymers.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82950854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.003
S. Shalini, N. Reddy
{"title":"Immediate Denture - Case Report","authors":"S. Shalini, N. Reddy","doi":"10.46624/ajptr.2020.v10.i3.003","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.003","url":null,"abstract":"","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88020536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.004
Saumil Desai, Ashish Kharadi
GIST is a visceral sarcoma that arises from the gastrointestinal tract. The clinical features and radiologic differential diagnosis of gastrointestinal stromal tumours are discussed. Gastrointestinal stromal tumours is a rare gastrointestinal tumour. Computed tomography (CT) is an imaging modality of choice for diagnosing GIST. The aim of this Retrospective study is to evaluate CT feature of GIST in20 cases. In this study 20 biopsy proven cases of GIST were evaluated retrospectively in our department from November 2010 to July 2012. The CT scan was performed prior to the treatment in all these patients. CT imaging feature includes, tumour location, size/diameter, degree & pattern of enhancement, intraluminal/exophytic, internal necrosis & haemorrhage, perilesional rat stranding, local spread, nodal & distant metastasis. Out of 20 patients, in 13/20 (65 %) cases tumour was found in stomach, 4/20 (20%) in small bowel (jejunum & ileum), 2/20 (10%) in omentum and mesentery; and 1 (5%) case tumour was found in transverse colon. 14/20 (70%) had exophytic tumour with communicating to lumen of gastrointestinal tract or in omentum and mesentery; rest 6/20 (30%) had polypoidal mass. Size of tumour ranges from 4 to 15 cm, with mean of 7.9 cm.15/20 (75%) cases shows heterogeneous enhancement with necrosis and/or calcification, rest 5/20 (25%) had homogenous enhancement. The CT HU ranges from 35 to 55, with mean of 40, 14/20 (75 %) cases had well defined margins of tumour, and rest 6 (30%) cases showed perilesional fat stranding and loss of fat plane with adjacent organ.2/20 (10%) cases showed regional nodal involvement and 3/20 (15%) cases shows distant metastasis to liver(2) & lungs (1).
{"title":"CT imaging of GIST (Gastrointestinal Stromal Tumour): Retrospective study of 20 cases.","authors":"Saumil Desai, Ashish Kharadi","doi":"10.46624/ajptr.2020.v10.i3.004","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.004","url":null,"abstract":"GIST is a visceral sarcoma that arises from the gastrointestinal tract. The clinical features and radiologic differential diagnosis of gastrointestinal stromal tumours are discussed. Gastrointestinal stromal tumours is a rare gastrointestinal tumour. Computed tomography (CT) is an imaging modality of choice for diagnosing GIST. The aim of this Retrospective study is to evaluate CT feature of GIST in20 cases. In this study 20 biopsy proven cases of GIST were evaluated retrospectively in our department from November 2010 to July 2012. The CT scan was performed prior to the treatment in all these patients. CT imaging feature includes, tumour location, size/diameter, degree & pattern of enhancement, intraluminal/exophytic, internal necrosis & haemorrhage, perilesional rat stranding, local spread, nodal & distant metastasis. Out of 20 patients, in 13/20 (65 %) cases tumour was found in stomach, 4/20 (20%) in small bowel (jejunum & ileum), 2/20 (10%) in omentum and mesentery; and 1 (5%) case tumour was found in transverse colon. 14/20 (70%) had exophytic tumour with communicating to lumen of gastrointestinal tract or in omentum and mesentery; rest 6/20 (30%) had polypoidal mass. Size of tumour ranges from 4 to 15 cm, with mean of 7.9 cm.15/20 (75%) cases shows heterogeneous enhancement with necrosis and/or calcification, rest 5/20 (25%) had homogenous enhancement. The CT HU ranges from 35 to 55, with mean of 40, 14/20 (75 %) cases had well defined margins of tumour, and rest 6 (30%) cases showed perilesional fat stranding and loss of fat plane with adjacent organ.2/20 (10%) cases showed regional nodal involvement and 3/20 (15%) cases shows distant metastasis to liver(2) & lungs (1).","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87950611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-08DOI: 10.46624/ajptr.2020.v10.i3.011
SK Asmath Begum, K. Swamy
Please cite this article as: Swamy K et al., Studies on the anti obesity activity of ethanolic extract of Centella Asiatica in Triton-X, High fat diet and Progesterone induced obesity. American Journal of PharmTech Research 2019. Studies on the anti obesity activity of ethanolic extract of Centella Asiatica in Triton-X, High fat diet and Progesterone induced obesity . SK Asmath Begum*, Kumar Swamy Sri Venkateswara university college of sciences, Sri venkateswara University, Tirupati-517502, Andhra Pradesh , India. ABSTRACT Our aim in the present study was to evaluate the anti-obesity activity of Centella asiatica in high fat diet (HFD), Triton-X and Progesterone induced obese rats and mice. Ethanolic extract od centella asiativa was prepared And the extract is tested with different doses(100mg/kg, 200mg/kg, 400mg/kg) and the efficiency of EECA is comparable to that of orlistat (20mg/kg b.wt), a standard anti-obesity drug. Although food consumption was moderately increased in HFD-fed rats, EECA administration significantly reduced weight gain in them. Serum total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) levels were significantly (P< 0.05) lowered, while high density lipoproteins (HDL) increased in EECA administered with different (HFD, Triton-X, Progesterone) Based on our results we demonstrate that EECA has potential anti-obesity activity.
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