Annual review of cell and developmental biology最新文献

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Expansion Microscopy: Scalable and Convenient Super-Resolution Microscopy. 扩展显微镜:可扩展和方便的超分辨率显微镜。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100818-125320

Paul W. Tillberg, Fei Chen

Expansion microscopy (ExM) is a physical form of magnification that increases the effective resolving power of any microscope. Here, we describe the fundamental principles of ExM, as well as how recently developed ExM variants build upon and apply those principles. We examine applications of ExM in cell and developmental biology for the study of nanoscale structures as well as ExM's potential for scalable mapping of nanoscale structures across large sample volumes. Finally, we explore how the unique anchoring and hydrogel embedding properties enable postexpansion molecular interrogation in a purified chemical environment. ExM promises to play an important role complementary to emerging live-cell imaging techniques, because of its relative ease of adoption and modification and its compatibility with tissue specimens up to at least 200 μm thick. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

膨胀显微镜（ExM）是一种物理放大形式，可以提高任何显微镜的有效分辨率。在这里，我们描述了ExM的基本原理，以及最近开发的ExM变体是如何建立和应用这些原理的。我们研究了ExM在细胞和发育生物学中研究纳米级结构的应用，以及ExM在大样本量上可扩展绘制纳米级结构图的潜力。最后，我们探索了独特的锚定和水凝胶包埋特性如何在纯化的化学环境中实现膨胀后分子询问。ExM有望发挥重要作用，补充新兴的活细胞成像技术，因为它相对容易采用和修改，并且与厚度至少200μm的组织样本兼容。《细胞与发育生物学年度评论》第35卷预计最终在线出版日期为2019年10月7日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

引用次数: 24

Neurovascular Interactions in the Nervous System. 神经系统中的神经血管相互作用。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100818-125142

M. Segarra, M. R. Aburto, Jasmin K. Hefendehl, A. Acker-Palmer

Molecular cross talk between the nervous and vascular systems is necessary to maintain the correct coupling of organ structure and function. Molecular pathways shared by both systems are emerging as major players in the communication of the neuronal compartment with the endothelium. Here we review different aspects of this cross talk and how vessels influence the development and homeostasis of the nervous system. Beyond the classical role of the vasculature as a conduit to deliver oxygen and metabolites needed for the energy-demanding neuronal compartment, vessels emerge as powerful signaling systems that control and instruct a variety of cellular processes during the development of neurons and glia, such as migration, differentiation, and structural connectivity. Moreover, a broad spectrum of mild to severe vascular dysfunctions occur in various pathologies of the nervous system, suggesting that mild structural and functional changes at the neurovascular interface may underlie cognitive decline in many of these pathological conditions.

神经和血管系统之间的分子串扰对于维持器官结构和功能的正确耦合是必要的。两个系统共享的分子通路正在成为神经元隔室与内皮沟通的主要参与者。在这里，我们回顾了这种串扰的不同方面，以及血管如何影响神经系统的发育和稳态。除了血管系统作为输送能量需求神经元室所需氧气和代谢物的管道的经典作用外，血管还成为强大的信号系统，在神经元和神经胶质发育过程中控制和指导各种细胞过程，如迁移、分化和结构连接。此外，神经系统的各种病理中都会出现广泛的轻度至重度血管功能障碍，这表明神经-血管界面的轻度结构和功能变化可能是许多这些病理条件下认知能力下降的基础。

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引用次数: 54

Plant Cell Polarity: Creating Diversity from Inside the Box. 植物细胞极性:从盒子里创造多样性。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100818-125211

A. Muroyama, D. Bergmann

Cell polarity in plants operates across a broad range of spatial and temporal scales to control processes from acute cell growth to systemic hormone distribution. Similar to other eukaryotes, plants generate polarity at both the subcellular and tissue levels, often through polarization of membrane-associated protein complexes. However, likely due to the constraints imposed by the cell wall and their extremely plastic development, plants possess novel polarity molecules and mechanisms highly tuned to environmental inputs. Considerable progress has been made in identifying key plant polarity regulators, but detailed molecular understanding of polarity mechanisms remains incomplete in plants. Here, we emphasize the striking similarities in the conceptual frameworks that generate polarity in both animals and plants. To this end, we highlight how novel, plant-specific proteins engage in common themes of positive feedback, dynamic intracellular trafficking, and posttranslational regulation to establish polarity axes in development. We end with a discussion of how environmental signals control intrinsic polarity to impact postembryonic organogenesis and growth.

植物的细胞极性在广泛的空间和时间尺度上起作用，控制着从细胞急性生长到全身激素分布的过程。与其他真核生物类似，植物在亚细胞和组织水平上产生极性，通常是通过膜相关蛋白复合物的极化。然而，可能是由于细胞壁的限制和它们极具可塑性的发育，植物具有新的极性分子和高度适应环境输入的机制。在确定植物极性调节因子方面已经取得了相当大的进展，但对植物极性机制的详细分子理解仍不完整。在这里，我们强调在动物和植物中产生极性的概念框架中惊人的相似性。为此，我们强调了新颖的植物特异性蛋白质如何参与正反馈、动态细胞内运输和翻译后调节的共同主题，以建立发育中的极性轴。我们最后讨论了环境信号如何控制内在极性以影响胚胎后器官发生和生长。

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引用次数: 24

Plant Noncoding RNAs: Hidden Players in Development and Stress Responses. 植物非编码rna:在发育和胁迫反应中的隐藏角色。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100818-125218

Yu Yu, Yuchan Zhang, Xuemei Chen, Yue‐Qin Chen

A large and significant portion of eukaryotic transcriptomes consists of noncoding RNAs (ncRNAs) that have minimal or no protein-coding capacity but are functional. Diverse ncRNAs, including both small RNAs and long ncRNAs (lncRNAs), play essential regulatory roles in almost all biological processes by modulating gene expression at the transcriptional and posttranscriptional levels. In this review, we summarize the current knowledge of plant small RNAs and lncRNAs, with a focus on their biogenesis, modes of action, local and systemic movement, and functions at the nexus of plant development and environmental responses. The complex connections among small RNAs, lncRNAs, and small peptides in plants are also discussed, along with the challenges of identifying and investigating new classes of ncRNAs. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

真核生物转录组中有很大一部分是由非编码rna (ncRNAs)组成的，这些非编码rna具有很少或没有蛋白质编码能力，但具有功能。多种ncrna，包括小rna和长ncrna (lncrna)，通过在转录和转录后水平调节基因表达，在几乎所有生物过程中发挥重要的调节作用。本文综述了植物小rna和lncrna的最新研究进展，重点介绍了它们的生物起源、作用方式、局部和系统运动以及它们在植物发育和环境响应中的作用。还讨论了植物中小rna、lncrna和小肽之间的复杂联系，以及鉴定和研究新型ncrna的挑战。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

引用次数: 176

Autophagy in Neurons. 神经元中的自噬。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 Epub Date: 2019-07-23 DOI: 10.1146/annurev-cellbio-100818-125242

Andrea K H Stavoe, Erika L F Holzbaur

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged or damaged mitochondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. These pathways are required in neurodevelopment as well as in the maintenance of neuronal homeostasis. Here we review the core components of the pathway for autophagosome biogenesis, as well as the cell biology of bulk and selective autophagy in neurons. Finally, we discuss the role of autophagy in neuronal development, homeostasis, and aging and the links between deficits in autophagy and neurodegeneration.

自噬是细胞降解功能失调细胞器和蛋白质聚集体的主要途径。自噬在神经元中尤为重要，神经元是终末分化的细胞，必须持续整个生物体的生命周期。神经元自噬有构成性和应激诱导两种途径，可催化老化或受损的线粒体、内质网、其他细胞器和聚集蛋白的更新。这些通路在神经发育和维持神经元稳态中都是必需的。在此，我们综述了自噬体生物发生途径的核心成分，以及神经元中大量和选择性自噬的细胞生物学。最后，我们讨论了自噬在神经元发育、稳态和衰老中的作用，以及自噬缺陷与神经变性之间的联系。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

引用次数: 0

Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport. 细胞物流：解开微管组织和细胞内运输之间的相互关系。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100818-125149

M. Burute, L. Kapitein

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein-based intracellular transport. Microtubule networks are highly diverse across different cell types and are believed to adapt to cell type-specific transport demands. Here we review how the spatial organization of different subsets of microtubules into higher-order networks determines the traffic rules for motor-based transport in different animal cell types. We describe the interplay between microtubule network organization and motor-based transport within epithelial cells, oocytes, neurons, cilia, and the spindle apparatus. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

微管是细胞骨架的核心组成部分，是基于运动蛋白的细胞内运输的轨道。微管网络在不同的细胞类型中高度多样化，并且被认为适应细胞类型特异性的运输需求。在这里，我们回顾了微管的不同子集在高阶网络中的空间组织如何决定不同动物细胞类型中基于运动的运输的交通规则。我们描述了微管网络组织和上皮细胞、卵母细胞、神经元、纤毛和纺锤体内基于运动的运输之间的相互作用。《细胞与发育生物学年度评论》第35卷预计最终在线出版日期为2019年10月7日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

引用次数: 56

Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management. 多任务处理:双亮氨酸拉链承载激酶在神经元发育和压力管理。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 DOI: 10.1146/annurev-cellbio-100617-062644

Yishi Jin, B. Zheng

The dual leucine zipper-bearing kinase (DLK) and leucine zipper-bearing kinase (LZK) are evolutionarily conserved MAPKKKs of the mixed-lineage kinase family. Acting upstream of stress-responsive JNK and p38 MAP kinases, DLK and LZK have emerged as central players in neuronal responses to a variety of acute and traumatic injuries. Recent studies also implicate their function in astrocytes, microglia, and other nonneuronal cells, reflecting their expanding roles in the multicellular response to injury and in disease. Of particular note is the potential link of these kinases to neurodegenerative diseases and cancer. It is thus critical to understand the physiological contexts under which these kinases are activated, as well as the signal transduction mechanisms that mediate specific functional outcomes. In this review we first provide a historical overview of the biochemical and functional dissection of these kinases. We then discuss recent findings on regulating their activity to enhance cellular protection following injury and in disease, focusing on but not limited to the nervous system.

双亮氨酸带拉链激酶(DLK)和亮氨酸带拉链激酶(LZK)是混合谱系激酶家族中进化保守的MAPKKKs。作为应激反应JNK和p38 MAP激酶的上游，DLK和LZK在各种急性和创伤性损伤的神经元反应中发挥着核心作用。最近的研究也暗示了它们在星形胶质细胞、小胶质细胞和其他非神经元细胞中的功能，反映了它们在多细胞损伤反应和疾病中的作用。特别值得注意的是这些激酶与神经退行性疾病和癌症的潜在联系。因此，了解这些激酶被激活的生理背景以及介导特定功能结果的信号转导机制是至关重要的。在这篇综述中，我们首先提供了这些激酶的生化和功能解剖的历史概述。然后，我们讨论了在损伤和疾病中调节其活性以增强细胞保护的最新发现，重点关注但不限于神经系统。

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引用次数: 17

Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development. 先天性淋巴细胞和树突状细胞发育的共同转录控制

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-10-06 Epub Date: 2019-07-05 DOI: 10.1146/annurev-cellbio-100818-125403

Prachi Bagadia, Xiao Huang, Tian-Tian Liu, Kenneth M Murphy

Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.

先天性免疫和适应性免疫由高度特化的免疫系组成，它们的功能和发育都依赖于转录因子。在这篇综述中，我们将剖析先天性淋巴细胞（ILCs）和树突状细胞（DCs）这两个先天性免疫系与适应性免疫系 T 细胞之间的相似之处。先天性淋巴细胞、树突状细胞和 T 细胞组成了四个功能性免疫模块，它们相互作用，共同产生特定的免疫反应。这三个免疫系也共享转录网络，管理每个系的发育，我们将在这篇综述中讨论 ILC 和 DC 之间的相似之处。

引用次数: 0

Not Just Going with the Flow: The Effects of Fluid Flow on Bacteria and Plankton. 不只是随波逐流:流体对细菌和浮游生物的影响。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-08-14 DOI: 10.1146/annurev-cellbio-100818-125119

J. Wheeler, E. Secchi, R. Rusconi, R. Stocker

Microorganisms often live in habitats characterized by fluid flow, from lakes and oceans to soil and the human body. Bacteria and plankton experience a broad range of flows, from the chaotic motion characteristic of turbulence to smooth flows at boundaries and in confined environments. Flow creates forces and torques that affect the movement, behavior, and spatial distribution of microorganisms and shapes the chemical landscape on which they rely for nutrient acquisition and communication. Methodological advances and closer interactions between physicists and biologists have begun to reveal the importance of flow-microorganism interactions and the adaptations of microorganisms to flow. Here we review selected examples of such interactions from bacteria, phytoplankton, larvae, and zooplankton. We hope that this article will serve as a blueprint for a more in-depth consideration of the effects of flow in the biology of microorganisms and that this discussion will stimulate further multidisciplinary effort in understanding this important component of microorganism habitats. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

微生物通常生活在以流体为特征的栖息地，从湖泊和海洋到土壤和人体。细菌和浮游生物经历的流动范围很广，从湍流的混沌运动特征到边界和受限环境中的平滑流动。水流产生的力和扭矩影响微生物的运动、行为和空间分布，并形成微生物赖以获取和交流营养的化学景观。方法的进步和物理学家和生物学家之间更密切的互动已经开始揭示流动-微生物相互作用和微生物适应流动的重要性。在这里，我们回顾了从细菌、浮游植物、幼虫和浮游动物中选择的这种相互作用的例子。我们希望这篇文章将作为一个蓝图，为更深入地考虑微生物生物学中流动的影响，并希望这一讨论将激发进一步的多学科努力，以理解微生物栖息地的这一重要组成部分。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

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引用次数: 60

Cell Motility and Cytokinesis: From Mysteries to Molecular Mechanisms in Five Decades. 细胞运动和细胞分裂:50年来从谜团到分子机制。

IF 11.3 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology

Pub Date : 2019-08-08 DOI: 10.1146/annurev-cellbio-100818-125427

T. Pollard

This is the story of someone who has been fortunate to work in a field of research where essentially nothing was known at the outset but blossomed with the discovery of profound insights about two basic biological processes: cell motility and cytokinesis. The field started with no molecules, just a few people, and primitive methods. Over time, technological advances in biophysics, biochemistry, and microscopy allowed the combined efforts of scientists in hundreds of laboratories to explain mysterious processes with molecular mechanisms that can be embodied in mathematical equations and simulated by computers. The success of this field is a tribute to the power of the reductionist strategy for understanding biology. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

这是一个关于一个研究领域的人的故事，这个领域一开始基本上一无所知，但随着对两个基本生物过程——细胞运动和细胞分裂——的深刻见解的发现而蓬勃发展。这个领域开始时没有分子，只有几个人和原始的方法。随着时间的推移，生物物理学、生物化学和显微镜技术的进步，使得数百个实验室的科学家们共同努力，用分子机制来解释神秘的过程，这些过程可以体现在数学方程中，并由计算机模拟。这一领域的成功是对还原论理解生物学策略的力量的致敬。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

引用次数: 12

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