Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.07.206
Elif Sar, T. Tokat, A. Aliyeva, M. Karadağ, Fatma Eren, Tolgahan Catl, L. Olgun
{"title":"Assessment of Vitamin D Levels in Patients with Sudden Sensorineural Hearing Loss","authors":"Elif Sar, T. Tokat, A. Aliyeva, M. Karadağ, Fatma Eren, Tolgahan Catl, L. Olgun","doi":"10.5455/annalsmedres.2022.07.206","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.07.206","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87189207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.02.047
kriye Ta, rem Dilaver, S. N., Birg Tok
Aim : Non-alcoholic fatty liver disease (NAFLD) has recently become a significant public health problem around the world, with a reported prevalence of 25%. In this study, we aimed to investigate the utility of biochemical and hematological markers in the progression from hepatosteatosis to fibrosis and to examine their superiority to each other by comparing them with pathological scoring parameters. Materials and Methods: : Pathological results of patients who underwent liver biopsy for different indications were reviewed retrospectively.Of these, 120 patients with fatty liver were selected and their biopsy specimens were re-evaluated according to the NAFLD Activity Score (NAS). The relationship between pathological scores and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST to platelet ratio index (APRI), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), RDW to platelet ratio (RPR), and gamma-glutamyl transpeptidase (GGT), RDW to platelet ratio (RPR), and gamma-glutamyl transpeptidase (GGT) was analyzed Results: The results indicated that ALT, APRI, and GGT were significant predictors of nonalcoholic steatohepatitis (NASH), while GGT, APRI, and RPR were significant predictors of fibrosis. Additionally, ROC analysis confirmed the significant predictive value of APRI, RPR, and GGT in the diagnosis of fibrosis. Conclusion:. Based on these results, we consider that GGT and APRI are better predictors than other biomarkers.
{"title":"PREDICTIVE VALUE OF BIOMARKERS IN STEATOHEPATITIS AND FIBROSIS","authors":"kriye Ta, rem Dilaver, S. N., Birg Tok","doi":"10.5455/annalsmedres.2023.02.047","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.02.047","url":null,"abstract":"Aim : Non-alcoholic fatty liver disease (NAFLD) has recently become a significant public health problem around the world, with a reported prevalence of 25%. In this study, we aimed to investigate the utility of biochemical and hematological markers in the progression from hepatosteatosis to fibrosis and to examine their superiority to each other by comparing them with pathological scoring parameters. Materials and Methods: : Pathological results of patients who underwent liver biopsy for different indications were reviewed retrospectively.Of these, 120 patients with fatty liver were selected and their biopsy specimens were re-evaluated according to the NAFLD Activity Score (NAS). The relationship between pathological scores and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST to platelet ratio index (APRI), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), RDW to platelet ratio (RPR), and gamma-glutamyl transpeptidase (GGT), RDW to platelet ratio (RPR), and gamma-glutamyl transpeptidase (GGT) was analyzed Results: The results indicated that ALT, APRI, and GGT were significant predictors of nonalcoholic steatohepatitis (NASH), while GGT, APRI, and RPR were significant predictors of fibrosis. Additionally, ROC analysis confirmed the significant predictive value of APRI, RPR, and GGT in the diagnosis of fibrosis. Conclusion:. Based on these results, we consider that GGT and APRI are better predictors than other biomarkers.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86208673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.09.285
A. M. Res, G. Yucel
Aim: In the investigation of the diagnosis of pediatric syncope, it was aimed to evaluate the rate of abnormal EEG findings and the diagnostic yield of the EEG in the electroencephalography (EEG) taken following their neurological examination. Materials and Methods: EEG records of 332 patients younger than 18 years of age who presented to the pediatric neurology outpatient clinic with syncope were retrospectively analyzed. The EEG results were classified as normal and abnormal. Based on the abnormal EEG results, four subgroups were formed as focal epileptiform discharge, generalized epileptiform discharge, focal slowing and generalized slowing. Abnormal EEG results were categorized according to age and gender. Results: Of the cases included in the study, 195 (58.7%) were female and 137 (41.3%) were male. The mean age of the patients was calculated as 12.67±3.21 years. Analysis of the EEG results revealed that 92.5% were normal and 7.53% were abnormal. The most common abnormal EEG finding was focal slowing, which was detected in 12 (3.6%) patients, followed by focal epileptiform discharge which was detected in eight (2.4%) and generalized epileptiform discharge which was detected in five (1.5%) patients. Conclusion: EEG should not be routinely performed to evaluate the diagnosis of pediatric syncope. Therefore, EEG should be performed only on patients to be selected based on their medical history and the results of their neurological examination. In this way, it will be possible to derive more benefits out of EEG and to reduce the associated medical costs.
{"title":"The diagnostic value of electroencephalography in pediatric patients presenting with syncope \u0000\u0000Running title: The yield of electroencephalography in pediatric syncope","authors":"A. M. Res, G. Yucel","doi":"10.5455/annalsmedres.2022.09.285","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.285","url":null,"abstract":"Aim: In the investigation of the diagnosis of pediatric syncope, it was aimed to evaluate the rate of abnormal EEG findings and the diagnostic yield of the EEG in the electroencephalography (EEG) taken following their neurological examination. Materials and Methods: EEG records of 332 patients younger than 18 years of age who presented to the pediatric neurology outpatient clinic with syncope were retrospectively analyzed. The EEG results were classified as normal and abnormal. Based on the abnormal EEG results, four subgroups were formed as focal epileptiform discharge, generalized epileptiform discharge, focal slowing and generalized slowing. Abnormal EEG results were categorized according to age and gender. Results: Of the cases included in the study, 195 (58.7%) were female and 137 (41.3%) were male. The mean age of the patients was calculated as 12.67±3.21 years. Analysis of the EEG results revealed that 92.5% were normal and 7.53% were abnormal. The most common abnormal EEG finding was focal slowing, which was detected in 12 (3.6%) patients, followed by focal epileptiform discharge which was detected in eight (2.4%) and generalized epileptiform discharge which was detected in five (1.5%) patients. Conclusion: EEG should not be routinely performed to evaluate the diagnosis of pediatric syncope. Therefore, EEG should be performed only on patients to be selected based on their medical history and the results of their neurological examination. In this way, it will be possible to derive more benefits out of EEG and to reduce the associated medical costs.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80469943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.09.283
A. M. Res, Mumune Bozdag Kiraz, Nevra Oksuz, O. Doğu
{"title":"EVALUATION OF THE PRESENCE OF RE-EMERGENT TREMOR AND ITS EFFECT ON CLINICAL FEATURES IN PARKINSON'S DISEASE","authors":"A. M. Res, Mumune Bozdag Kiraz, Nevra Oksuz, O. Doğu","doi":"10.5455/annalsmedres.2022.09.283","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.09.283","url":null,"abstract":"<jats:p />","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"77 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89715675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.07.169
A. M. Res, G. Yucel, S. Gungor
Abstract Objective: The aim was to evaluate the clinical and laboratory characteristics of children with Wilson's disease (WD) with and without neurological presentation with abnormalities on brain magnetic resonance imaging (MRI) and to describe the relationship of these observations with disease severity and functional outcome and their impact on prognosis. Materials and methods: Demographic, neuropsychiatric findings, laboratory, disease severity and functional results of 48 children with neurologically symptomatic and asymptomatic WD were evaluated retrospectively. Results: A significant positive correlation was found between the neurologic symptom score and functional outcome in WD with neurological presentation (p <0.001). A significant positive correlation was found between disease severity scores (PELD, MELD, Child Pugh and Dhwin score) and modified Rankin scores (mRS) in WD without neurological presentation (p <0.001, 0.004, <0.001, 0.001, respectively). In addition, a significant positive correlation was found between total bilirubin, direct bilirubin and Internationel Normalized Ratio (INR) values and mRS scores (p= 0.006, 0.012, 0.004, respectively). Kayser-Fleischer Ring sign in the eye was higher in the group with neurological symtomatic WD (p <0.001). The number of patients presenting with clinic of fulminant hepatitis and hepatic encephalopathy was significantly higher in the neurological asymptomatic group (p <0.001) Conclusion: Brain MRI changes may occur even in hepatic WD and presymptomatic cases, although infrequently, regardless of the presence of neurological symptoms. It should be known that neurological symptoms in children and adolescents may occur without significant liver disease. Even without neurological symptoms, all children with WD should have a brain MRI before treatment.
{"title":"Evaluation of neurologically symptomatic and asymptomatic patients in childhood Wilson's disease with central nervous system involvement: A retrospective observational study","authors":"A. M. Res, G. Yucel, S. Gungor","doi":"10.5455/annalsmedres.2023.07.169","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.07.169","url":null,"abstract":"Abstract Objective: The aim was to evaluate the clinical and laboratory characteristics of children with Wilson's disease (WD) with and without neurological presentation with abnormalities on brain magnetic resonance imaging (MRI) and to describe the relationship of these observations with disease severity and functional outcome and their impact on prognosis. Materials and methods: Demographic, neuropsychiatric findings, laboratory, disease severity and functional results of 48 children with neurologically symptomatic and asymptomatic WD were evaluated retrospectively. Results: A significant positive correlation was found between the neurologic symptom score and functional outcome in WD with neurological presentation (p <0.001). A significant positive correlation was found between disease severity scores (PELD, MELD, Child Pugh and Dhwin score) and modified Rankin scores (mRS) in WD without neurological presentation (p <0.001, 0.004, <0.001, 0.001, respectively). In addition, a significant positive correlation was found between total bilirubin, direct bilirubin and Internationel Normalized Ratio (INR) values and mRS scores (p= 0.006, 0.012, 0.004, respectively). Kayser-Fleischer Ring sign in the eye was higher in the group with neurological symtomatic WD (p <0.001). The number of patients presenting with clinic of fulminant hepatitis and hepatic encephalopathy was significantly higher in the neurological asymptomatic group (p <0.001) Conclusion: Brain MRI changes may occur even in hepatic WD and presymptomatic cases, although infrequently, regardless of the presence of neurological symptoms. It should be known that neurological symptoms in children and adolescents may occur without significant liver disease. Even without neurological symptoms, all children with WD should have a brain MRI before treatment.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79566819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.03.109
Fatih Baygutalp, Abbas Razm, Mansur Lu
ABSTRACT Aim: This study aims to numerically determine the biomechanical effect of von Mises stress, induced at different flexion angles of the spine while sitting at a desktop computer, on the soft tissues in the front and back of the lumbosacral region, as well as to contribute to determining the ideal sitting posture. Materials and Methods: Three-dimensional (3D) soft tissue models were created using Solidworks. Static structural analyses of the tissues were performed in ANSYS with the finite element method (FEM). Stress distribution and stress values occurring in the anterior and posterior sides of the lumbosacral region at 0, 15, 30, and 45 spine flexion angles were analyzed separately. The values of von Mises stress formed in the anterior and posterior soft tissues of the lumbosacral region gradually increased with the increase in the flexion angle. Furthermore, the stress values in the anterior and posterior soft tissues were compared with each other for the same spinal flexion angle. Results: The von Mises stress values were found to be higher in the posterior side only at 0 degrees, whereas at 15, 30, and 45 degrees, they were higher in the anterior side. As a result, the most suitable position for sitting at a computer was determined. Lower flexion angles of the spine, such as 0 and 15 degrees, create less stress on the anterior and posterior sides of the lumbosacral region. Conclusion: Sitting postures with a flexion angle of the spine higher than 0-15 degrees are not appropriate, and desktop users are not recommended to adopt such a posture. The results of the analysis could be used to better understand the effects of prolonged sitting on the lumbosacral area and to design interventions to reduce the risk of injury or discomfort.
{"title":"Finite element analysis of lumbosacral soft tissue at sitting posture at desktop computer","authors":"Fatih Baygutalp, Abbas Razm, Mansur Lu","doi":"10.5455/annalsmedres.2022.03.109","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.03.109","url":null,"abstract":"ABSTRACT Aim: This study aims to numerically determine the biomechanical effect of von Mises stress, induced at different flexion angles of the spine while sitting at a desktop computer, on the soft tissues in the front and back of the lumbosacral region, as well as to contribute to determining the ideal sitting posture. Materials and Methods: Three-dimensional (3D) soft tissue models were created using Solidworks. Static structural analyses of the tissues were performed in ANSYS with the finite element method (FEM). Stress distribution and stress values occurring in the anterior and posterior sides of the lumbosacral region at 0, 15, 30, and 45 spine flexion angles were analyzed separately. The values of von Mises stress formed in the anterior and posterior soft tissues of the lumbosacral region gradually increased with the increase in the flexion angle. Furthermore, the stress values in the anterior and posterior soft tissues were compared with each other for the same spinal flexion angle. Results: The von Mises stress values were found to be higher in the posterior side only at 0 degrees, whereas at 15, 30, and 45 degrees, they were higher in the anterior side. As a result, the most suitable position for sitting at a computer was determined. Lower flexion angles of the spine, such as 0 and 15 degrees, create less stress on the anterior and posterior sides of the lumbosacral region. Conclusion: Sitting postures with a flexion angle of the spine higher than 0-15 degrees are not appropriate, and desktop users are not recommended to adopt such a posture. The results of the analysis could be used to better understand the effects of prolonged sitting on the lumbosacral area and to design interventions to reduce the risk of injury or discomfort.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79005133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2022.08.240
Sinem Ozpar, Selcan Akesen, F. Kahveci
Purpose: To evaluate the efficiency of the capnography monitoring added to routine monitoring on oxygen desaturation, hypoxemia, and other vital parameters. Methods: 100 adult patients who had elective vitrectomy under sedation were included in this study. Patients were divided into “experiment”(capnography added to routine monitoring) and “control”(capnography not added to routine monitoring) groups. Hypoxemia, desaturation, tachycardia, bradycardia, additional maneuvers for the airway were compared. Increase and decrease in end-tidal carbon dioxide (EtCO2) levels, hypoxemia, desaturation, Integrated Pulmonary Index (IPI) levels requiring attention (5-7), and intervention (1-4) were determined in the experiment group, and frequencies of them were assessed. Results: Desaturation and bradycardia rates and counts in the experiment group were significantly lower than the control group. No significant difference was seen between groups in terms of hypoxemia, tachycardia, and additional maneuvers. 76%(38/50) of experiment group patients had decrease in EtCO2, 10%(5/50) increase in EtCO2, 38%(19/50) apnea, 52%(26/50) IPI levels requiring attention, 14%(7/50) IPI levels requiring intervention. Conclusion: With addition of the capnography to routine monitoring of sedated vitrectomy patients, oxygen desaturation and bradycardia can be less likely to occur, and with instant follow-up of the EtCO2, apnea, and IPI levels; respiratory depression can be recognized before oxygen desaturation develops.
{"title":"ROLE OF CAPNOGRAPHY IN SAFE SEDATION OF VITRECTOMY PATIENTS","authors":"Sinem Ozpar, Selcan Akesen, F. Kahveci","doi":"10.5455/annalsmedres.2022.08.240","DOIUrl":"https://doi.org/10.5455/annalsmedres.2022.08.240","url":null,"abstract":"Purpose: To evaluate the efficiency of the capnography monitoring added to routine monitoring on oxygen desaturation, hypoxemia, and other vital parameters. Methods: 100 adult patients who had elective vitrectomy under sedation were included in this study. Patients were divided into “experiment”(capnography added to routine monitoring) and “control”(capnography not added to routine monitoring) groups. Hypoxemia, desaturation, tachycardia, bradycardia, additional maneuvers for the airway were compared. Increase and decrease in end-tidal carbon dioxide (EtCO2) levels, hypoxemia, desaturation, Integrated Pulmonary Index (IPI) levels requiring attention (5-7), and intervention (1-4) were determined in the experiment group, and frequencies of them were assessed. Results: Desaturation and bradycardia rates and counts in the experiment group were significantly lower than the control group. No significant difference was seen between groups in terms of hypoxemia, tachycardia, and additional maneuvers. 76%(38/50) of experiment group patients had decrease in EtCO2, 10%(5/50) increase in EtCO2, 38%(19/50) apnea, 52%(26/50) IPI levels requiring attention, 14%(7/50) IPI levels requiring intervention. Conclusion: With addition of the capnography to routine monitoring of sedated vitrectomy patients, oxygen desaturation and bradycardia can be less likely to occur, and with instant follow-up of the EtCO2, apnea, and IPI levels; respiratory depression can be recognized before oxygen desaturation develops.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81084987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.206
Sinem Sensoy, Yeliz Arici
Aim: The aim of this study was to compare the robustness of some association coefficients used to determine the relationships between categorical variables under different experimental conditions. Material and Methods: A simulation study was conducted where random numbers were generated from a bivariate standard normal distribution with correlations of 0.5 and 0.9. Sample sizes were set at 30, 50, 100, 150 and 200. Random numbers were equally spaced and coded as 3×3, 4×4 and 5×5 cross-tabulations, respectively. The robustness of Pearson’s, Spearman's rank, Kendall's tau-b, Kendall's tau-c, Goodman-Kruskal’s gamma and Somer's d coefficients were compared under different experimental conditions consisting of combinations of specified population correlation degrees, table dimensions and sample sizes. Results: The Goodman-Kruskal’s gamma coefficient gave the closest result to the relationship levels set at the beginning of the study in all experimental conditions. However, after a certain level, it was negatively affected by the increase in table dimension and sample size. Kendall's tau-b and tau-c coefficients were furthest from the actual degree of the association. Spearman's rank correlation was more robust than Kendall's tau-b, Kendall's tau-c and Somer's d coefficients. Conclusion: The results of the study showed that the dimension of the contingency tables and sample size were effective factors in the robustness of association coefficients for categorical variables. Therefore, researchers should consider the table dimension and sample size as well as the type of variable when selecting the association coefficient to be calculated.
{"title":"Comparison via Simulation of Association Coefficients Calculated between Categorical Variables","authors":"Sinem Sensoy, Yeliz Arici","doi":"10.5455/annalsmedres.2023.08.206","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.206","url":null,"abstract":"Aim: The aim of this study was to compare the robustness of some association coefficients used to determine the relationships between categorical variables under different experimental conditions. Material and Methods: A simulation study was conducted where random numbers were generated from a bivariate standard normal distribution with correlations of 0.5 and 0.9. Sample sizes were set at 30, 50, 100, 150 and 200. Random numbers were equally spaced and coded as 3×3, 4×4 and 5×5 cross-tabulations, respectively. The robustness of Pearson’s, Spearman's rank, Kendall's tau-b, Kendall's tau-c, Goodman-Kruskal’s gamma and Somer's d coefficients were compared under different experimental conditions consisting of combinations of specified population correlation degrees, table dimensions and sample sizes. Results: The Goodman-Kruskal’s gamma coefficient gave the closest result to the relationship levels set at the beginning of the study in all experimental conditions. However, after a certain level, it was negatively affected by the increase in table dimension and sample size. Kendall's tau-b and tau-c coefficients were furthest from the actual degree of the association. Spearman's rank correlation was more robust than Kendall's tau-b, Kendall's tau-c and Somer's d coefficients. Conclusion: The results of the study showed that the dimension of the contingency tables and sample size were effective factors in the robustness of association coefficients for categorical variables. Therefore, researchers should consider the table dimension and sample size as well as the type of variable when selecting the association coefficient to be calculated.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.08.232
G ENER, Cihan kun, Esra lu, Ba Can, Bet Evran
Background: While type 2 diabetes (T2DM) is increasing rapidly, developing diabetic complications are the leading cause of morbidity and mortality. Biochemical markers are important for early diagnosis and treatment of nephropathy, which is a common complication. The aim of this study is to evaluate serum ischemia-modified albumin (IMA) levels in the development of diabetic nephropathy in T2DM patients and to determine the effectiveness of this parameter in predicting the presence and severity of nephropathy. Materials and Methods: 68 adult patients diagnosed with T2DM and 30 healthy controls were included in this study. The T2DM group consisted of 34 patients without microalbuminuria (<30 mg/g) and 34 patients with microalbuminuria (30–300 mg/g) according to albumin/creatinine ratio (UACR). Biochemical data and serum IMA levels of the patient and control groups were measured and compared. Results: In terms of IMA levels, the difference between T2DM patients with microalbuminuria (0.55 ± 0.08 ABSU) and without microalbuminuria (0.42 ± 0.05 ABSU) and control (0.37 ± 0.08 ABSU) groups was significant (p<0.0001). The T2DM group with microalbuminuria had the highest glucose, HbA1c, UACR, and IMA levels. There was a positive correlation between IMA levels and UACR (r = 0.541, p < 0.001). IMA had a weak correlation with HbA1c (r = 0.345, p = 0.002). ROC analysis was performed and the IMA test had a high diagnostic value in the diagnostic differentiation of T2DM patients with microalbuminuria. According to multiple logistic regression analysis, IMA levels were an independent risk factor for DN (p = 0.003). Conclusions: Our data showed that IMA values increased significantly in diabetic patients, especially in those with microalbuminuria, and this increase was correlated with UACR levels. This study has shown that increased IMA levels are an important marker for the presence and severity of microalbuminuria in diabetic patients and therefore may be important in the early detection of renal dysfunction in T2DM. We even think that it can be used as an important marker in the follow-up of diabetic patients, even before the development of microalbuminuria.
背景:随着2型糖尿病(T2DM)的迅速增加，糖尿病并发症是发病率和死亡率的主要原因。生化指标对肾病的早期诊断和治疗具有重要意义，肾病是常见的并发症。本研究的目的是评估2型糖尿病患者发生糖尿病肾病时血清缺血修饰白蛋白(IMA)水平，并确定该参数在预测肾病存在和严重程度方面的有效性。材料与方法:68例诊断为T2DM的成年患者和30例健康对照者纳入本研究。T2DM组按白蛋白/肌酐比值(UACR)分为34例无微量白蛋白尿患者(≤30mg /g)和34例微量白蛋白尿患者(≤30mg /g)。测定患者与对照组的生化指标及血清IMA水平，并进行比较。结果:T2DM微量白蛋白尿组(0.55±0.08 ABSU)、无微量白蛋白尿组(0.42±0.05 ABSU)与对照组(0.37±0.08 ABSU) IMA水平差异有统计学意义(p<0.0001)。伴有微量白蛋白尿的T2DM组血糖、HbA1c、UACR和IMA水平最高。IMA水平与UACR呈正相关(r = 0.541, p <0.001)。IMA与HbA1c的相关性较弱(r = 0.345, p = 0.002)。进行ROC分析，IMA试验对T2DM合并微量白蛋白尿的诊断鉴别有较高的诊断价值。多元logistic回归分析显示IMA水平是DN的独立危险因素(p = 0.003)。结论:我们的数据显示，IMA值在糖尿病患者中显著升高，特别是在微量白蛋白尿患者中，这种升高与UACR水平相关。本研究表明，IMA水平升高是糖尿病患者微量白蛋白尿存在和严重程度的重要标志，因此可能对T2DM肾功能障碍的早期检测具有重要意义。我们甚至认为它可以作为糖尿病患者随访的一个重要标志，甚至在发展为微量白蛋白尿之前。
{"title":"The Relationship with Disease Severity of Ischemia-Modified Albumin Levels in Diabetic Nephropathy","authors":"G ENER, Cihan kun, Esra lu, Ba Can, Bet Evran","doi":"10.5455/annalsmedres.2023.08.232","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.08.232","url":null,"abstract":"Background: While type 2 diabetes (T2DM) is increasing rapidly, developing diabetic complications are the leading cause of morbidity and mortality. Biochemical markers are important for early diagnosis and treatment of nephropathy, which is a common complication. The aim of this study is to evaluate serum ischemia-modified albumin (IMA) levels in the development of diabetic nephropathy in T2DM patients and to determine the effectiveness of this parameter in predicting the presence and severity of nephropathy. Materials and Methods: 68 adult patients diagnosed with T2DM and 30 healthy controls were included in this study. The T2DM group consisted of 34 patients without microalbuminuria (<30 mg/g) and 34 patients with microalbuminuria (30–300 mg/g) according to albumin/creatinine ratio (UACR). Biochemical data and serum IMA levels of the patient and control groups were measured and compared. Results: In terms of IMA levels, the difference between T2DM patients with microalbuminuria (0.55 ± 0.08 ABSU) and without microalbuminuria (0.42 ± 0.05 ABSU) and control (0.37 ± 0.08 ABSU) groups was significant (p<0.0001). The T2DM group with microalbuminuria had the highest glucose, HbA1c, UACR, and IMA levels. There was a positive correlation between IMA levels and UACR (r = 0.541, p < 0.001). IMA had a weak correlation with HbA1c (r = 0.345, p = 0.002). ROC analysis was performed and the IMA test had a high diagnostic value in the diagnostic differentiation of T2DM patients with microalbuminuria. According to multiple logistic regression analysis, IMA levels were an independent risk factor for DN (p = 0.003). Conclusions: Our data showed that IMA values increased significantly in diabetic patients, especially in those with microalbuminuria, and this increase was correlated with UACR levels. This study has shown that increased IMA levels are an important marker for the presence and severity of microalbuminuria in diabetic patients and therefore may be important in the early detection of renal dysfunction in T2DM. We even think that it can be used as an important marker in the follow-up of diabetic patients, even before the development of microalbuminuria.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135802051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/annalsmedres.2023.07.164
ESMA KIRIMLIOGLU, AHMET YAPICI
Objective: Platelet-rich plasma (PRP) is the cellular plasma component containing a higher platelet concentration obtained by centrifugation of autologous peripheral blood. PRP has an auxiliary role in regenerative medicine treatment. Current treatment protocols for tissue repair strategies may be globally insufficient. PRP treatment via Platelet-released growth factors (GF) supports inflammation, proliferation, and wound healing. PRP studies have progressed and have proposed different formulations in recent years. Although various methods and devices are used, there are few and different standardized protocols to obtain PRP with the highest platelet concentration. Although anticoagulants containing citrate are primarily preferred in PRP production To provide effective platelet concentration in PRP, we noticed differences in the literature regarding PRP tube volumes, anticoagulant-citrate, and blood amounts. We aimed to obtain the most appropriate platelet concentration in PRP treatment by using different concentration ratios of Acid Citrate dextrose (ACD) solution A and different blood amounts and introducing a new treatment method to the literature. Methods: The blood of 30 individuals aged between 30 and 75 was taken into 10cc laboratory tubes, and 15cc and 18cc hourglass-shaped PRP tubes containing 8% ACD-solution A. Blood fractions were separated by centrifugation, buffy coat area was collected, and count platelet amount by Hematology Analyzer. Results: The platelet amount per µl was statistically significantly higher in 18cc blood compared to 15cc and 10cc. Platelet amounts obtained from 15 and 18cc peripheral blood with 8% ACD-solution A were above the effective treatment amount recommended in the literature. Conclusion: It was observed that the amount of used blood volume was correlated with the amount of obtained platelets.
{"title":"DETERMINATION OF THE OPTIMUM PLATELET-RICH PLASMA METHOD FOR THE ESSENTIAL AMOUNT OF PLATELETS","authors":"ESMA KIRIMLIOGLU, AHMET YAPICI","doi":"10.5455/annalsmedres.2023.07.164","DOIUrl":"https://doi.org/10.5455/annalsmedres.2023.07.164","url":null,"abstract":"Objective: Platelet-rich plasma (PRP) is the cellular plasma component containing a higher platelet concentration obtained by centrifugation of autologous peripheral blood. PRP has an auxiliary role in regenerative medicine treatment. Current treatment protocols for tissue repair strategies may be globally insufficient. PRP treatment via Platelet-released growth factors (GF) supports inflammation, proliferation, and wound healing. PRP studies have progressed and have proposed different formulations in recent years. Although various methods and devices are used, there are few and different standardized protocols to obtain PRP with the highest platelet concentration. Although anticoagulants containing citrate are primarily preferred in PRP production To provide effective platelet concentration in PRP, we noticed differences in the literature regarding PRP tube volumes, anticoagulant-citrate, and blood amounts. We aimed to obtain the most appropriate platelet concentration in PRP treatment by using different concentration ratios of Acid Citrate dextrose (ACD) solution A and different blood amounts and introducing a new treatment method to the literature. Methods: The blood of 30 individuals aged between 30 and 75 was taken into 10cc laboratory tubes, and 15cc and 18cc hourglass-shaped PRP tubes containing 8% ACD-solution A. Blood fractions were separated by centrifugation, buffy coat area was collected, and count platelet amount by Hematology Analyzer. Results: The platelet amount per µl was statistically significantly higher in 18cc blood compared to 15cc and 10cc. Platelet amounts obtained from 15 and 18cc peripheral blood with 8% ACD-solution A were above the effective treatment amount recommended in the literature. Conclusion: It was observed that the amount of used blood volume was correlated with the amount of obtained platelets.","PeriodicalId":8248,"journal":{"name":"Annals of Medical Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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