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Examining the underreporting of social determinants of health in randomized controlled trials published in spine journals 检查在脊柱期刊上发表的随机对照试验中对健康的社会决定因素的漏报
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-12 DOI: 10.1007/s00402-026-06243-1
Michael N. Megafu, Jacob T. Ayers, Lance C. Evans, Spencer A. Newell, Michelle Uwefoh, Omar D. Guerrero, Andrew C. Hecht, James Lin, Robert L. Parisien, Investigation Performed by the Scientific Collaborative for Orthopaedic Research and Education (SCORE) Group

Introduction

Social determinants of health (SDOH) are nonmedical factors that influence patient outcomes. This study aimed to determine the prevalence of randomized controlled trials (RCTs) reporting SDOH factors in their patient cohorts within several of the highest-impact spinal surgery journals. We hypothesize that SDOH factors will be infrequently reported and often miss variables such as socioeconomic status, employment status, insurance, and education level.

Methods

From 2020 to 2024, the PubMed database was queried to analyze spine RCTs reporting SDOHs from four high-impact journals. For each study, we determined the age, sex, and/or gender, body mass index (BMI), the year the article was published, the country of origin of the senior author, and self-reported SDOH factors.

Results

Of the 147 included RCTs, age (95.9%), sex/gender (94.6%), and BMI (72.8%) were reported by the majority of studies. There were a total of 33 countries represented by the RCTs reporting spine outcomes, where 25 (17.0%) RCTs were conducted in the United States, 22 (15.0%) RCTs conducted in China, 11 (7.5%) RCTs in the Netherlands, 9 (6.1%) RCTs in Japan and 9 (6.1%) RCTs in Turkey.

Conclusion

This paper provides valuable insights into the landscape of spine research and emphasizes the necessity of consistently reporting all SDOH factors. Future research can better inform clinical practice and policy decisions by addressing these considerations, ultimately improving healthcare outcomes for spine patients worldwide.

健康的社会决定因素(SDOH)是影响患者预后的非医学因素。本研究旨在确定在几个最具影响力的脊柱外科期刊中报道SDOH因素的随机对照试验(rct)在其患者队列中的流行程度。我们假设SDOH因素将很少被报道,并且经常遗漏诸如社会经济地位、就业状况、保险和教育水平等变量。方法从2020年到2024年,查询PubMed数据库,分析4种高影响力期刊报道SDOHs的脊柱随机对照试验。对于每项研究,我们确定了年龄、性别、身体质量指数(BMI)、文章发表年份、资深作者的原籍国和自我报告的SDOH因素。结果在纳入的147项随机对照试验中,大多数研究报告了年龄(95.9%)、性别/性别(94.6%)和BMI(72.8%)。共有33个国家的随机对照试验报告了脊柱结局,其中美国25项(17.0%)随机对照试验,中国22项(15.0%)随机对照试验,荷兰11项(7.5%)随机对照试验,日本9项(6.1%)随机对照试验,土耳其9项(6.1%)。结论:本文为脊柱研究提供了有价值的见解,并强调了一致报告所有SDOH因素的必要性。通过解决这些问题,未来的研究可以更好地为临床实践和政策决策提供信息,最终改善全球脊柱患者的医疗保健结果。
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引用次数: 0
Obesity and long bone fractures in children. Systematic review 儿童肥胖与长骨骨折。系统的回顾。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-10 DOI: 10.1007/s00402-026-06221-7
Ahmed Aly, Tarek Aly

Background

Childhood obesity is a pressing global health issue with potential implications for musculoskeletal injury risk and recovery. Although the influence of obesity on bone metabolism is acknowledged, its specific connection to the incidence, patterns, and treatment results of long bone fractures in the pediatric demographic requires further clarification.

Purpose

This systematic review aims to evaluate the existing literature on the relationship between obesity and long bone fractures in children and adolescents, with a focus on fracture risk, anatomical distribution, management approaches, and clinical outcomes.

Methods

We conducted a systematic literature search of PubMed, MEDLINE, Cochrane Library, and Google Scholar for studies published from January 2000 to March 2025. Search terms included “childhood obesity”, “bone health”, and “long bone fractures”. We included English-language original research that analyzed the relationship between pediatric obesity (BMI ≥ 95th percentile) and long bone fractures. Data on study characteristics, fracture patterns, treatments, and outcomes were extracted.

Results

Out of 2,152 articles screened, 14 met the inclusion criteria. Children who were overweight or obese had higher odds of lower extremity fractures, particularly of the tibia and femur (odds ratios 1.5–3.3). Obesity was linked to more complex fracture patterns, including physical involvement and displacement, and a higher failure rate of nonsurgical management, especially for forearm and supracondylar fractures. Operative complications, such as varus deformity and pin-related issues, were more frequent in obese patients. However, no consistent differences were observed between obese and non-obese groups regarding mortality and long-term functional outcomes.

Conclusions

Pediatric obesity significantly elevates the risk and complexity of long bone fractures and complicates both nonoperative and surgical management. Acknowledging these challenges is crucial for optimizing treatment and preventing adverse outcomes. Further multicenter prospective studies are needed to clarify the underlying biomechanical and metabolic mechanisms and to guide the development of individualized management protocols.

Level of evidence

Systematic Review, Level III.

儿童肥胖是一个紧迫的全球健康问题,对肌肉骨骼损伤的风险和恢复有潜在的影响。虽然肥胖对骨代谢的影响是公认的,但它与儿童长骨骨折的发病率、模式和治疗结果的具体联系需要进一步澄清。目的本系统综述旨在对儿童和青少年肥胖与长骨骨折之间关系的现有文献进行评估,重点关注骨折的风险、解剖分布、处理方法和临床结果。方法系统检索PubMed、MEDLINE、Cochrane Library和谷歌Scholar网站2000年1月至2025年3月发表的研究。搜索词包括“儿童肥胖”、“骨骼健康”和“长骨骨折”。我们纳入了分析儿童肥胖(BMI≥95百分位)与长骨骨折之间关系的英文原始研究。提取有关研究特征、骨折类型、治疗和结果的数据。结果筛选的2152篇文献中,14篇符合纳入标准。超重或肥胖的儿童下肢骨折的几率更高,尤其是胫骨和股骨(优势比为1.5-3.3)。肥胖与更复杂的骨折类型有关,包括身体受损伤和移位,非手术治疗失败率更高,尤其是前臂和髁上骨折。手术并发症,如内翻畸形和针相关问题,在肥胖患者中更常见。然而,肥胖组和非肥胖组在死亡率和长期功能结局方面没有一致的差异。结论儿童肥胖显著增加了长骨骨折的风险和复杂性,并使非手术和手术治疗复杂化。认识到这些挑战对于优化治疗和预防不良后果至关重要。需要进一步的多中心前瞻性研究来阐明潜在的生物力学和代谢机制,并指导个性化管理方案的发展。证据等级:系统评价,III级。
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引用次数: 0
TGCT of the shoulder – a case series and literature review 肩部TGCT:病例系列及文献回顾。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06237-z
Josefa Stadelmeier, Filip Bijeljac, Alexander Klein, Felix Winden, Paul Reidler, Hans Roland Dürr

Introduction

Tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis (PVNS), involving the shoulder is extremely rare and can present with a challenging clinical course. Due to the complex anatomy of the shoulder, both diagnosis and treatment are demanding. This study aims to evaluate the diagnostic and therapeutic management of shoulder TGCT based on a case series and a review of the literature.

Materials and methods

Between 2005 and 2021, four patients (2 females, 2 males) with shoulder TGCT (1 localized, 3 diffuse) underwent surgical treatment at our institution. The minimum follow-up was 39 months (range: 39–233 months). Functional outcomes were assessed using the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), the Oxford Shoulder Score (OSS), and the Short Form 36 Health Survey (SF-36). Additionally, a literature review of 65 studies comprising 108 patients was performed.

Results

Treatments consisted of arthroscopic and open resections, tendon repair, adjuvant radiosynoviorthesis, and radiotherapy, as appropriate. All patients were recurrence-free at the last follow-up, except for one with stable residual disease after radiotherapy. The mean interval from symptom onset to diagnosis was 23.6 ± 28.1 months. In the literature cohort, the mean patient age was 50.3 ± 19.7 years, with a nearly equal gender distribution. Diffuse TGCT was more common (66.1%) than nodular TGCT (33.8%). Treatment was primarily surgery, arthroscopic (53.2%) or open (42.9%), with adjuvant therapies applied in 9.3% of cases. After a mean follow-up of 37.6 ± 36.2 months in 67 cases, diffuse in 44.8%, nodular in 19.4% (no data regarding TGCT-type in 35.8%) the reported recurrence rate was 10.6% and 4.5% remained with residual disease.

Conclusions

TGCT of the shoulder remains a rare and complex condition requiring individualized treatment strategies. Arthroscopic and open resections are the mainstays of therapy, while the role of adjuvant treatments should be carefully considered. Given the risk of recurrence, follow-up is essential. Further studies are needed to establish standardized treatment protocols and evaluate long-term outcomes.

Level of evidence

Level IV (Case series with no comparison group).

腱鞘巨细胞瘤(TGCT),又称色素绒毛结节性滑膜炎(PVNS),累及肩部极为罕见,临床过程具有挑战性。由于肩部复杂的解剖结构,诊断和治疗都要求很高。本研究旨在通过一系列病例和文献回顾来评估肩部TGCT的诊断和治疗管理。材料和方法2005年至2021年间,我院共收治4例肩部TGCT患者(2女2男)(1例局限性,3例弥漫性)。最小随访时间为39个月(39 - 233个月)。使用手臂、肩膀和手的残疾问卷(DASH)、牛津肩部评分(OSS)和短表36健康调查(SF-36)评估功能结果。此外,对包括108例患者在内的65项研究进行了文献综述。结果治疗方法包括关节镜和切开切除、肌腱修复、辅助放射滑膜成形术和适当的放射治疗。最后一次随访时,除1例放疗后残留病变稳定外,其余均无复发。从症状出现到诊断的平均时间间隔为23.6±28.1个月。在文献队列中,患者平均年龄为50.3±19.7岁,性别分布几乎相等。弥漫性TGCT(66.1%)高于结节性TGCT(33.8%)。治疗主要是手术、关节镜(53.2%)或开放(42.9%),9.3%的病例采用辅助治疗。67例患者平均随访37.6±36.2个月,弥漫性44.8%,结节性19.4%(无tgct类型资料35.8%),复发率10.6%,残余病变4.5%。结论肩部stgct是一种罕见且复杂的疾病,需要个性化的治疗策略。关节镜和开放切除是治疗的主要方法,同时应仔细考虑辅助治疗的作用。考虑到复发的风险,随访是必要的。需要进一步的研究来建立标准化的治疗方案和评估长期结果。证据水平:IV级(病例系列,无对照组)。
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引用次数: 0
Recommendations of an international Delphi study group for total knee arthroplasty in obese patients 国际德尔菲研究小组对肥胖患者全膝关节置换术的建议。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06220-8
Ashok Rajgopal, Dhanasekara Raja Palanisami, Adarsh Annapareddy, Moin Khan, Raju Easwaran, Ashok Shyam, Sahil Sanghavi, Parag Sancheti

Introduction

Total knee arthroplasty (TKA) in obese patients poses multiple challenges and there is a lack of consensus on various aspects of TKA in this patient population. This study is a modified Delphi consensus study of international experts to provide recommendations on TKA in obese patients.

Materials and methods

The consensus statements were generated using an anonymized two-round modified Delphi questionnaire, sent to an international panel of 53 knee surgeons, with an 80% agreement being set as the limit for consensus. The responses were analysed using descriptive statistics, with median as the measure of central tendency. Anonymized feedback was provided to all panellists based on responses from previous rounds to help generate the consensus.

Results

9 statements reached a consensus: WHO classification (87%), BMI cut-off for single-stage bilateral TKA (92%), use of tibial stem (84%), medial parapatellar approach (92%), same surgical approach as non-obese TKA (92%), inherent malnutrition (82%), higher risk of aseptic loosening in BMI class 3 (81%), need for time interval between bilateral TKA (88%), and consensus against leaving the knee in slight flexion (82%). The panel was unable to reach a consensus on 17 statements.

Conclusion

This indicates lack of consensus on a majority of issues among experts and further research is required in this field to address evidence gaps, so we can improve our management of this increasing cohort of patients undergoing TKA. The statements reaching consensus form an important set of recommendation to improve patient selection and outcomes.

Level of evidence Level V

引言:肥胖患者的全膝关节置换术(TKA)面临多重挑战,在该患者群体中TKA的各个方面缺乏共识。本研究是一项修正的德尔福共识研究,旨在为肥胖患者的TKA提供建议。材料和方法:共识陈述是通过匿名的两轮修改的德尔菲问卷生成的,发送给53名膝关节外科医生的国际小组,80%的同意被设定为共识的限制。使用描述性统计分析应答,以中位数作为集中趋势的度量。根据前几轮的反馈,向所有小组成员提供了匿名反馈,以帮助达成共识。结果:9项声明达成共识:WHO分类(87%),单期双侧TKA的BMI分界点(92%),使用胫骨干(84%),内侧髌旁入路(92%),与非肥胖TKA相同的手术入路(92%),固有营养不良(82%),BMI 3级无菌性松动风险较高(81%),双侧TKA需要间隔时间(88%),一致反对让膝盖轻微弯曲(82%)。该小组未能就17项声明达成共识。结论:这表明专家在大多数问题上缺乏共识,需要在该领域进一步研究以解决证据差距,因此我们可以改善对这一不断增加的TKA患者的管理。达成共识的声明形成了一套重要的建议,以改善患者的选择和结果。证据等级V级。
{"title":"Recommendations of an international Delphi study group for total knee arthroplasty in obese patients","authors":"Ashok Rajgopal,&nbsp;Dhanasekara Raja Palanisami,&nbsp;Adarsh Annapareddy,&nbsp;Moin Khan,&nbsp;Raju Easwaran,&nbsp;Ashok Shyam,&nbsp;Sahil Sanghavi,&nbsp;Parag Sancheti","doi":"10.1007/s00402-026-06220-8","DOIUrl":"10.1007/s00402-026-06220-8","url":null,"abstract":"<div><h3>Introduction</h3><p>Total knee arthroplasty (TKA) in obese patients poses multiple challenges and there is a lack of consensus on various aspects of TKA in this patient population. This study is a modified Delphi consensus study of international experts to provide recommendations on TKA in obese patients.</p><h3>Materials and methods</h3><p>The consensus statements were generated using an anonymized two-round modified Delphi questionnaire, sent to an international panel of 53 knee surgeons, with an 80% agreement being set as the limit for consensus. The responses were analysed using descriptive statistics, with median as the measure of central tendency. Anonymized feedback was provided to all panellists based on responses from previous rounds to help generate the consensus.</p><h3>Results</h3><p>9 statements reached a consensus: WHO classification (87%), BMI cut-off for single-stage bilateral TKA (92%), use of tibial stem (84%), medial parapatellar approach (92%), same surgical approach as non-obese TKA (92%), inherent malnutrition (82%), higher risk of aseptic loosening in BMI class 3 (81%), need for time interval between bilateral TKA (88%), and consensus against leaving the knee in slight flexion (82%). The panel was unable to reach a consensus on 17 statements.</p><h3>Conclusion</h3><p>This indicates lack of consensus on a majority of issues among experts and further research is required in this field to address evidence gaps, so we can improve our management of this increasing cohort of patients undergoing TKA. The statements reaching consensus form an important set of recommendation to improve patient selection and outcomes.</p><p><i>Level of evidence</i> Level V </p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing outcomes of total hip arthroplasty between cirrhotic and non-cirrhotic patients through a propensity-matched analysis 通过倾向匹配分析比较肝硬化和非肝硬化患者全髋关节置换术的结果。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06214-6
Muhammad Haider, Farouk Khury, Jonathan Katzman, Patrick Connolly, Anzar Sarfraz, Ran Schwarzkopf, Claudette M. Lajam

Background

The impact of liver cirrhosis on surgical outcomes is well-known. This study aimed to compare postoperative outcomes of total hip arthroplasty (THA) in patients with versus without cirrhosis.

Methods

A retrospective review was conducted of all patients who received a THA between 2012 and 2021 with a minimum of two years of clinical follow-up at a single, urban tertiary health center with lab results available to calculate Model for End-stage Liver Disease (MELD) scores. Using demographic variables, patients with and without cirrhosis underwent a 10:1 propensity score match. Short-term clinical outcomes were compared between cohorts. Cirrhotic patients were stratified based on their MELD score as mild (MELD < 10, n = 39) or moderate-to-severe (MELD ≥ 10, n = 10).

Results

Of the 539 patients included in this study, 49 patients were in the cirrhotic group and 490 patients were in the non-cirrhotic group. Compared to non-cirrhotic and mild cirrhotic, moderate-to-severe cirrhotic THA patients had significantly higher incidence of 30-day (2.9% vs. 2.6% vs. 30.0%, p = 0.011) and 90-day readmissions (5.9% vs. 2.6% vs. 30.0%, p = 0.038) due to periprosthetic joint infection (PJI), and higher incidence of 90-day (3.1% vs. 2.6% vs. 20.0%, p = 0.024) and all-time revisions (1.4% vs. 5.1% vs. 20.0%, p = 0.016) due to PJI. There were no differences in overall 90-day reoperation (p = 0.115) and revision risk (p = 0.202) between non-cirrhotic, mild cirrhotic, and moderate-to-severe cirrhotic THA patients. Freedom from all-cause reoperations/revisions did not differ significantly (p = 0.479) between non-cirrhotic and cirrhotic THA patients at 120 months of follow-up.

Conclusions

Cirrhotic patients, particularly those categorized as moderate-to-severe, undergoing THA may have higher risk of having a readmission or revision for PJI. However, overall 90-day readmission and revision risk were similar between non-cirrhotic and cirrhotic patients. Future research with larger sample sizes and databases is needed to further risk stratify, optimize and counsel cirrhosis patients surrounding THA.

背景肝硬化对手术结果的影响是众所周知的。本研究旨在比较肝硬化患者与无肝硬化患者全髋关节置换术(THA)的术后结果。方法回顾性分析2012年至2021年间接受THA的所有患者,在单个城市三级卫生中心进行至少两年的临床随访,实验室结果可用于计算终末期肝病模型(MELD)评分。使用人口统计学变量,有肝硬化和没有肝硬化的患者进行了10:1的倾向评分匹配。比较各组间的短期临床结果。根据MELD评分将肝硬化患者分为轻度(MELD≥10,n = 39)或中度至重度(MELD≥10,n = 10)。结果本研究纳入的539例患者中,49例为肝硬化组,490例为非肝硬化组。与非肝硬化和轻度肝硬化相比,中度至重度肝硬化THA患者因假体周围关节感染(PJI)而在30天内(2.9%比2.6%比30.0%,p = 0.011)和90天内再入院(5.9%比2.6%比30.0%,p = 0.038)的发生率显著高于非肝硬化和轻度肝硬化THA患者,并且由于PJI而在90天内(3.1%比2.6%比20.0%,p = 0.024)和所有翻修(1.4%比5.1%比20.0%,p = 0.016)的发生率更高。非肝硬化、轻度肝硬化和中重度肝硬化THA患者的90天再手术(p = 0.115)和翻修风险(p = 0.202)均无差异。在120个月的随访中,非肝硬化和肝硬化THA患者的全因再手术/翻修自由度无显著差异(p = 0.479)。结论:肝硬化患者,特别是那些中度至重度的患者,接受THA可能有更高的再入院或PJI翻修的风险。然而,总的90天再入院和翻修风险在非肝硬化和肝硬化患者之间是相似的。未来需要更大样本量和数据库的研究来进一步对THA周围肝硬化患者进行风险分层、优化和建议。
{"title":"Comparing outcomes of total hip arthroplasty between cirrhotic and non-cirrhotic patients through a propensity-matched analysis","authors":"Muhammad Haider,&nbsp;Farouk Khury,&nbsp;Jonathan Katzman,&nbsp;Patrick Connolly,&nbsp;Anzar Sarfraz,&nbsp;Ran Schwarzkopf,&nbsp;Claudette M. Lajam","doi":"10.1007/s00402-026-06214-6","DOIUrl":"10.1007/s00402-026-06214-6","url":null,"abstract":"<div><h3>Background</h3><p>The impact of liver cirrhosis on surgical outcomes is well-known. This study aimed to compare postoperative outcomes of total hip arthroplasty (THA) in patients with versus without cirrhosis.</p><h3>Methods</h3><p>A retrospective review was conducted of all patients who received a THA between 2012 and 2021 with a minimum of two years of clinical follow-up at a single, urban tertiary health center with lab results available to calculate Model for End-stage Liver Disease (MELD) scores. Using demographic variables, patients with and without cirrhosis underwent a 10:1 propensity score match. Short-term clinical outcomes were compared between cohorts. Cirrhotic patients were stratified based on their MELD score as mild (MELD &lt; 10, <i>n</i> = 39) or moderate-to-severe (MELD ≥ 10, <i>n</i> = 10).</p><h3>Results</h3><p>Of the 539 patients included in this study, 49 patients were in the cirrhotic group and 490 patients were in the non-cirrhotic group. Compared to non-cirrhotic and mild cirrhotic, moderate-to-severe cirrhotic THA patients had significantly higher incidence of 30-day (2.9% vs. 2.6% vs. 30.0%, <i>p</i> = 0.011) and 90-day readmissions (5.9% vs. 2.6% vs. 30.0%, <i>p</i> = 0.038) due to periprosthetic joint infection (PJI), and higher incidence of 90-day (3.1% vs. 2.6% vs. 20.0%, <i>p</i> = 0.024) and all-time revisions (1.4% vs. 5.1% vs. 20.0%, <i>p</i> = 0.016) due to PJI. There were no differences in overall 90-day reoperation (<i>p</i> = 0.115) and revision risk (<i>p</i> = 0.202) between non-cirrhotic, mild cirrhotic, and moderate-to-severe cirrhotic THA patients. Freedom from all-cause reoperations/revisions did not differ significantly (<i>p</i> = 0.479) between non-cirrhotic and cirrhotic THA patients at 120 months of follow-up.</p><h3>Conclusions</h3><p>Cirrhotic patients, particularly those categorized as moderate-to-severe, undergoing THA may have higher risk of having a readmission or revision for PJI. However, overall 90-day readmission and revision risk were similar between non-cirrhotic and cirrhotic patients. Future research with larger sample sizes and databases is needed to further risk stratify, optimize and counsel cirrhosis patients surrounding THA.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Immunological purification of rat precartilaginous stem cells and construction of the immortalized cell strain 修正:大鼠不稳定干细胞的免疫纯化和永生化细胞株的构建。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06231-5
Shuwei Zhang, Anmin Chen, Weihua Hu, Minghui Li, Hui Liao, Wentao Zhu, Dengxin Song, Fengjing Guo
{"title":"Correction: Immunological purification of rat precartilaginous stem cells and construction of the immortalized cell strain","authors":"Shuwei Zhang,&nbsp;Anmin Chen,&nbsp;Weihua Hu,&nbsp;Minghui Li,&nbsp;Hui Liao,&nbsp;Wentao Zhu,&nbsp;Dengxin Song,&nbsp;Fengjing Guo","doi":"10.1007/s00402-026-06231-5","DOIUrl":"10.1007/s00402-026-06231-5","url":null,"abstract":"","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The accumulation of technical errors exponentially increases the risk of screw cut-out in femoral intramedullary nailing 技术错误的积累成倍地增加了股骨髓内钉断螺钉的风险。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06263-x
Damien Brochard, Maëlys Thepaut, Thomas Daoulas, Arthur Poiri, Hoel Letissier, Rémi Di Francia

Purpose

Proximal femur fractures primarily affect the elderly, with significant morbidity, mortality, and socioeconomic impact. The main complication of short trochanteric intramedullary nailing is the cut-out of the cervicocapital screw through the femoral head. The objective of this study was to analyze the influence of technical errors in short trochanteric intramedullary nailing for the treatment of trochanteric femur fractures on the mechanical failure of osteosynthesis.

Methods

A total of 540 patients who underwent surgery for a trochanteric femur fracture using short trochanteric intramedullary nailing were included in a single-center, retrospective study conducted between February 2012 and July 2018.

Results

Thirty patients (5.6%) experienced mechanical failure of the osteosynthesis at the 3-month follow-up. An anterior position of the cervicocapital screw, accumulation of technical errors, a tip-apex distance > 25 mm, and an intra-focal entry point were significantly associated with cervicocapital screw cut-out.

Conclusion

The mechanical failure rate is 5.6%. Short trochanteric intramedullary nailing requires precise execution to reduce the risk of cervicocapital screw cut-out, which is a source of osteosynthesis failure.

目的:股骨近端骨折主要影响老年人,具有显著的发病率、死亡率和社会经济影响。短转子髓内钉的主要并发症是颈椎螺钉经股骨头切开。本研究的目的是分析短股骨粗隆髓内钉治疗股骨粗隆骨折的技术错误对成骨机械失效的影响。方法:在2012年2月至2018年7月进行的一项单中心回顾性研究中,共纳入540例使用短转子髓内钉治疗股骨粗隆骨折的患者。结果:30例(5.6%)患者在随访3个月时出现骨固定机械失效。颈椎螺钉的前位、技术错误的积累、尖端-尖端距离bbb25 mm和病灶内进入点与颈椎螺钉切断有显著关系。结论:机械故障率为5.6%。短转子髓内钉需要精确的执行,以减少颈资本螺钉切断的风险,这是骨折失败的一个来源。
{"title":"The accumulation of technical errors exponentially increases the risk of screw cut-out in femoral intramedullary nailing","authors":"Damien Brochard,&nbsp;Maëlys Thepaut,&nbsp;Thomas Daoulas,&nbsp;Arthur Poiri,&nbsp;Hoel Letissier,&nbsp;Rémi Di Francia","doi":"10.1007/s00402-026-06263-x","DOIUrl":"10.1007/s00402-026-06263-x","url":null,"abstract":"<div><h3>Purpose</h3><p>Proximal femur fractures primarily affect the elderly, with significant morbidity, mortality, and socioeconomic impact. The main complication of short trochanteric intramedullary nailing is the cut-out of the cervicocapital screw through the femoral head. The objective of this study was to analyze the influence of technical errors in short trochanteric intramedullary nailing for the treatment of trochanteric femur fractures on the mechanical failure of osteosynthesis.</p><h3>Methods</h3><p>A total of 540 patients who underwent surgery for a trochanteric femur fracture using short trochanteric intramedullary nailing were included in a single-center, retrospective study conducted between February 2012 and July 2018.</p><h3>Results</h3><p>Thirty patients (5.6%) experienced mechanical failure of the osteosynthesis at the 3-month follow-up. An anterior position of the cervicocapital screw, accumulation of technical errors, a tip-apex distance &gt; 25 mm, and an intra-focal entry point were significantly associated with cervicocapital screw cut-out.</p><h3>Conclusion</h3><p>The mechanical failure rate is 5.6%. Short trochanteric intramedullary nailing requires precise execution to reduce the risk of cervicocapital screw cut-out, which is a source of osteosynthesis failure.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of distal femoral morphology on short-term outcomes following high tibial osteotomy (HTO) in varus knees 股骨远端形态对膝内翻高位胫骨截骨(HTO)术后短期预后的影响。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06227-1
Ruoxuan Zhu, Maolin Wang, Juan Wang

Introduction

Despite the availability of various osteotomies for varus knee osteoarthritis, including proximal tibial, distal femoral, and fibular osteotomies, HTO is the most prevalent in clinical practice. The primary focus of this study is to investigate how distal femoral morphology influences the outcomes of HTO.

Methods

Demographic characteristics, radiographic parameters, and functional scores were collected preoperatively and at 2-year follow-up from patients undergoing HTO at our institution between January 2022 and July 2022. Patients were categorized into two cohorts based on the lateral distal femoral angle (LDFA): Group I (LDFA ≤ 89°) and Group II (LDFA > 89°). Each cohort was further stratified into three subgroups according to postoperative hip-knee-ankle angle (post-HKA): Subgroup A (HKA = 180° ± 0.5°), Subgroup B (HKA = 181° ± 0.5°), and Subgroup C (HKA = 182° ± 0.5°). Radiographic and functional outcomes were compared.

Results

The study included 191 patients distributed across six subgroups (IA: 33, IB:29, IC:29, IIA:37, IIB:30 and IIC:33). Significant inter-subgroup differences were observed in the change in joint line convergence angle (ΔJLCA) for both Group I (F = 11.876, P = 0.048) and Group II (F = 9.826, P = 0.042). ΔJLCA exhibited a positive correlation with the change in hip-knee-ankle angle (ΔHKA) in both groups (Group I: r = 0.323, P = 0.011; Group II: r = 0.522, P < 0.001). In Group I, postoperative joint line orientation angle (Post-JLOA) showed no significant differences. At 2-year follow-up, subgroup C demonstrated superiority in the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Oxford Knee Scores (OKS) compared to subgroup A(WOMAC:P = 0.006; OKS: P = 0.007). Changes in WOMAC and OKS (ΔWOMAC and ΔOKS) correlated positively with ΔHKA and ΔJLCA but showed no correlation with Post-JLOA. In Group II, Post-JLOA differed among the subgroups (F = 9.205, P = 0.035). At 2-year follow-up, Functional outcomes were comparable across subgroups. Both ΔWOMAC and ΔOKS positively correlated with ΔHKA and ΔJLCA but negatively with Post-JLOA.

Conclusion

A mechanical axis of 182° optimizes clinical outcomes in patients with normal femoral anatomy, while 180° is preferable for cases with distal femoral varus to minimize joint line obliquity.

尽管对于膝内翻性关节炎有多种截骨术,包括胫骨近端、股骨远端和腓骨截骨术,但HTO在临床实践中最为普遍。本研究的主要焦点是探讨股骨远端形态如何影响HTO的结果。方法收集2022年1月至2022年7月在我院接受HTO手术的患者术前和2年随访期间的人口统计学特征、影像学参数和功能评分。根据股骨外侧远端角度(LDFA)将患者分为两组:I组(LDFA≤89°)和II组(LDFA > 89°)。每个队列根据术后髋关节-膝关节-踝关节角度(HKA后)进一步分为三个亚组:A亚组(HKA = 180°±0.5°),B亚组(HKA = 181°±0.5°)和C亚组(HKA = 182°±0.5°)。比较影像学和功能预后。结果191例患者被分为6个亚组(IA: 33, IB:29, IC:29, IIA:37, IIB:30和IIC:33)。组I (F = 11.876, P = 0.048)和组II (F = 9.826, P = 0.042)关节线收敛角变化(ΔJLCA)亚组间差异有统计学意义。ΔJLCA与两组髋关节-膝关节-踝关节角度变化(ΔHKA)呈正相关(I组:r = 0.323, P = 0.011; II组:r = 0.522, P < 0.001)。组术后关节线定位角(Post-JLOA)差异无统计学意义。在2年的随访中,与A亚组相比,C亚组在西安大略省和麦克马斯特大学骨关节炎(WOMAC)和牛津膝关节评分(OKS)方面表现出优势(WOMAC:P = 0.006; OKS: P = 0.007)。WOMAC和OKS (ΔWOMAC和ΔOKS)的变化与ΔHKA和ΔJLCA呈正相关,但与jloa后无相关性。II组jloa后亚组间差异有统计学意义(F = 9.205, P = 0.035)。在2年的随访中,各亚组的功能结果具有可比性。ΔWOMAC、ΔOKS与ΔHKA、ΔJLCA呈正相关,与Post-JLOA呈负相关。结论股骨解剖正常患者机械轴为182°,股骨远端内翻患者机械轴为180°,可使关节线倾斜度最小。
{"title":"Impact of distal femoral morphology on short-term outcomes following high tibial osteotomy (HTO) in varus knees","authors":"Ruoxuan Zhu,&nbsp;Maolin Wang,&nbsp;Juan Wang","doi":"10.1007/s00402-026-06227-1","DOIUrl":"10.1007/s00402-026-06227-1","url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the availability of various osteotomies for varus knee osteoarthritis, including proximal tibial, distal femoral, and fibular osteotomies, HTO is the most prevalent in clinical practice. The primary focus of this study is to investigate how distal femoral morphology influences the outcomes of HTO.</p><h3>Methods</h3><p>Demographic characteristics, radiographic parameters, and functional scores were collected preoperatively and at 2-year follow-up from patients undergoing HTO at our institution between January 2022 and July 2022. Patients were categorized into two cohorts based on the lateral distal femoral angle (LDFA): Group I (LDFA ≤ 89°) and Group II (LDFA &gt; 89°). Each cohort was further stratified into three subgroups according to postoperative hip-knee-ankle angle (post-HKA): Subgroup A (HKA = 180° ± 0.5°), Subgroup B (HKA = 181° ± 0.5°), and Subgroup C (HKA = 182° ± 0.5°). Radiographic and functional outcomes were compared.</p><h3>Results</h3><p>The study included 191 patients distributed across six subgroups (IA: 33, IB:29, IC:29, IIA:37, IIB:30 and IIC:33). Significant inter-subgroup differences were observed in the change in joint line convergence angle (ΔJLCA) for both Group I (F = 11.876, <i>P</i> = 0.048) and Group II (F = 9.826, <i>P</i> = 0.042). ΔJLCA exhibited a positive correlation with the change in hip-knee-ankle angle (ΔHKA) in both groups (Group I: r = 0.323, <i>P</i> = 0.011; Group II: r = 0.522, <i>P</i> &lt; 0.001). In Group I, postoperative joint line orientation angle (Post-JLOA) showed no significant differences. At 2-year follow-up, subgroup C demonstrated superiority in the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Oxford Knee Scores (OKS) compared to subgroup A(WOMAC:<i>P</i> = 0.006; OKS: <i>P</i> = 0.007). Changes in WOMAC and OKS (ΔWOMAC and ΔOKS) correlated positively with ΔHKA and ΔJLCA but showed no correlation with Post-JLOA. In Group II, Post-JLOA differed among the subgroups (F = 9.205, <i>P</i> = 0.035). At 2-year follow-up, Functional outcomes were comparable across subgroups. Both ΔWOMAC and ΔOKS positively correlated with ΔHKA and ΔJLCA but negatively with Post-JLOA.</p><h3>Conclusion</h3><p>A mechanical axis of 182° optimizes clinical outcomes in patients with normal femoral anatomy, while 180° is preferable for cases with distal femoral varus to minimize joint line obliquity.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Properly designed femoral stem impactors help to avoid overstuffing and make a second trial reduction unnecessary 合理设计的股骨干冲击器有助于避免过度填充,避免不必要的第二次复位。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06242-2
Steffen Brodt, Sebastian Rohe, Philipp Knospe, Pablo Sanz-Ruiz, Georgi Wassilew, Georg Matziolis

Introduction

For cementless implantation of hip stems, it is very important that the original stem fits exactly into the femoral prosthesis bed previously shaped using a stem rasp. If the geometry of the stem rasp does not match the prosthesis geometry, this can result in either overstuffing or post-sintering of the original stem in relation to trial reduction with the stem rasp. Overstuffing results in leg lengthening, while subsidence of the stem results in shortening with the risk of dislocation and impingement. Trial reduction with the original stem and trial head can prevent this, but is associated with additional soft tissue trauma and a longer operating time.

Materials and methods

Three groups were prospectively randomized. Group 0 was treated with the Fitmore B stem and the conventional rasp system, Group 1 with the Optimys stem and Group 2 with the Fitmore B stem with a new, optimized rasp system via a minimally invasive posterolateral approach. Intraoperatively, the differences in leg length and offset between trial reduction with the stem rasp and the original stem were recorded using a hip navigation system.

Results

The conventional rasp system led to significant overstuffing (1.2 ± 0.5 mm, p = 0.024) with the Fitmore B stem, compared with the instruments of the Optimys stem. In contrast, the optimized rasp system with the Fitmore B stem resulted in an equally precise fit of the endoprosthesis to that achieved with Optimys.

Conclusion

There are relevant differences in the fit of rasp and original stem between different manufacturers and system evolutions. In order to ensure reproducible comparability of the fit of the original stem to the trial rasp, it is imperative that trial rasps are optimally adapted to the stems. This is an important way to avoid trial reduction after implantation of the original stem.

Trial registration

This study was registered in the German Clinical Trials Register (Deutsches Register Klinischer Studien) with the registration number DRKS00026749.

对于无骨水泥植入的髋关节干,非常重要的是,原始干完全适合股骨假体床先前使用干锉成形。如果柄锉的几何形状与假体的几何形状不匹配,这可能导致原始柄的填塞或后烧结,这与柄锉的试用减少有关。过度填充导致腿变长,而骨干下沉导致缩短,有脱位和撞击的风险。用原柄和试验头进行试验复位可以防止这种情况,但会造成额外的软组织损伤和更长的手术时间。材料与方法前瞻性随机分组。0组采用Fitmore B柄和传统的锉刀系统,1组采用Optimys柄,2组采用微创后外侧入路的Fitmore B柄和新的优化的锉刀系统。术中,使用髋关节导航系统记录试验复位与原始复位之间的腿长和偏移量的差异。结果与Optimys器械相比,常规锉制的Fitmore B器械出现明显的压塞现象(1.2±0.5 mm, p = 0.024)。相比之下,Fitmore B柄优化后的锉刀系统与Optimys实现了同样精确的假体配合。结论不同生产厂家、不同系统演进之间,棘轮与原杆的配合度存在相关差异。为了确保原始干与试验锉刀配合的可重复性可比性,必须使试验锉刀最佳地适应于茎。这是避免原茎植入术后试验减少的重要途径。试验注册本研究已在德国临床试验注册(Deutsches Register Klinischer studen)注册,注册号为DRKS00026749。
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引用次数: 0
Septic arthritis following intra-articular corticosteroid injections: a retrospective analysis 关节内皮质类固醇注射后脓毒性关节炎:回顾性分析。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-09 DOI: 10.1007/s00402-026-06262-y
Marlena Rose Mueller, Travis Cleland, Corrilynn O. Hileman, Andrew Olsen, Robert Wissner, Kimberley R. Monden

Introduction

Septic arthritis is a rare but devastating complication of intra-articular corticosteroid injection (CSI), associated with significant medical morbidity and poor clinical outcomes. Although previous studies have examined risks associated with CSI, few have tracked patients long-term. This study evaluates the incidence, timing, and patient characteristics related to iatrogenic septic arthritis within 6 months of receiving a large joint CSI, offering new insights to inform clinical practice.

Materials and methods

A retrospective, descriptive cohort study was conducted using SlicerDicer, a software stratification system within Epic, to identify patients diagnosed with septic arthritis within six months of receiving an intra-articular CSI of the hip, knee, or shoulder. Data were collected from a single institution over a 10-year period (July 1, 2010 to July 1, 2020). Individual chart review was used to obtain patient demographics, clinical characteristics, and procedural details for identified cases.

Results

Of 15,021 intra-articular corticosteroid injections performed, 14 cases of septic arthritis were identified within 6 months of the procedure, resulting in an incidence rate of 0.093%. Of the affected patients, 21% had underlying inflammatory arthritis, and 21% had underlying comorbidities resulting in immunosuppression. The median time to diagnosis was 3.5 (range 1–16) weeks post-injection, with a bimodal distribution of infections occurring primarily between 1 and 3 and 7–10 weeks post-injection. Staphylococcus aureus (42%) and coagulase-negative Staphylococcus species (36%) were the most commonly isolated organisms.

Conclusions

Large joint intra-articular CSI presents a low risk (< 0.1%) for developing septic arthritis, but can present up to 16 weeks post-injection. The preliminary observation of bimodal timing and delayed presentation of septic arthritis suggests that a standard two-week surveillance window may not be long enough to fully capture all infections, particularly those involving lower-virulence organisms. These findings highlight the need for informed risk stratification and prolonged vigilance well beyond the immediate post-injection period to identify infectious complications after large joint CSI.

脓毒性关节炎是关节内皮质类固醇注射(CSI)的一种罕见但破坏性的并发症,与显著的医学发病率和不良的临床结果相关。虽然以前的研究已经检查了与CSI相关的风险,但很少有长期追踪患者的研究。本研究评估了接受大关节CSI治疗后6个月内与医源性脓毒性关节炎相关的发病率、时间和患者特征,为临床实践提供了新的见解。材料和方法采用Epic公司的软件分层系统SlicerDicer进行了一项回顾性、描述性队列研究,以确定接受髋关节、膝关节或肩部关节内CSI治疗后6个月内诊断为脓毒性关节炎的患者。数据收集于同一家机构,时间跨度为10年(2010年7月1日至2020年7月1日)。个体图表回顾用于获得患者的人口统计学、临床特征和确定病例的程序细节。结果15021例关节内皮质类固醇注射中,14例化脓性关节炎在手术后6个月内被确诊,发生率为0.093%。在受影响的患者中,21%有潜在的炎症性关节炎,21%有潜在的合并症导致免疫抑制。中位诊断时间为注射后3.5周(范围1 - 16周),感染主要发生在注射后1 - 3周和7-10周。金黄色葡萄球菌(42%)和凝固酶阴性葡萄球菌(36%)是最常见的分离菌。结论:大关节关节内CSI发生脓毒性关节炎的风险较低(0.1%),但在注射后16周仍可能出现。对脓毒性关节炎的双峰时间和延迟表现的初步观察表明,标准的两周监测窗口可能不足以完全捕获所有感染,特别是那些涉及低毒力生物体的感染。这些发现强调了需要进行知情的风险分层,并在注射后立即保持警惕,以识别大关节CSI后的感染性并发症。
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引用次数: 0
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Archives of Orthopaedic and Trauma Surgery
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