Pub Date : 2026-03-12DOI: 10.1007/s00402-026-06243-1
Michael N. Megafu, Jacob T. Ayers, Lance C. Evans, Spencer A. Newell, Michelle Uwefoh, Omar D. Guerrero, Andrew C. Hecht, James Lin, Robert L. Parisien, Investigation Performed by the Scientific Collaborative for Orthopaedic Research and Education (SCORE) Group
Introduction
Social determinants of health (SDOH) are nonmedical factors that influence patient outcomes. This study aimed to determine the prevalence of randomized controlled trials (RCTs) reporting SDOH factors in their patient cohorts within several of the highest-impact spinal surgery journals. We hypothesize that SDOH factors will be infrequently reported and often miss variables such as socioeconomic status, employment status, insurance, and education level.
Methods
From 2020 to 2024, the PubMed database was queried to analyze spine RCTs reporting SDOHs from four high-impact journals. For each study, we determined the age, sex, and/or gender, body mass index (BMI), the year the article was published, the country of origin of the senior author, and self-reported SDOH factors.
Results
Of the 147 included RCTs, age (95.9%), sex/gender (94.6%), and BMI (72.8%) were reported by the majority of studies. There were a total of 33 countries represented by the RCTs reporting spine outcomes, where 25 (17.0%) RCTs were conducted in the United States, 22 (15.0%) RCTs conducted in China, 11 (7.5%) RCTs in the Netherlands, 9 (6.1%) RCTs in Japan and 9 (6.1%) RCTs in Turkey.
Conclusion
This paper provides valuable insights into the landscape of spine research and emphasizes the necessity of consistently reporting all SDOH factors. Future research can better inform clinical practice and policy decisions by addressing these considerations, ultimately improving healthcare outcomes for spine patients worldwide.
{"title":"Examining the underreporting of social determinants of health in randomized controlled trials published in spine journals","authors":"Michael N. Megafu, Jacob T. Ayers, Lance C. Evans, Spencer A. Newell, Michelle Uwefoh, Omar D. Guerrero, Andrew C. Hecht, James Lin, Robert L. Parisien, Investigation Performed by the Scientific Collaborative for Orthopaedic Research and Education (SCORE) Group","doi":"10.1007/s00402-026-06243-1","DOIUrl":"10.1007/s00402-026-06243-1","url":null,"abstract":"<div><h3>Introduction</h3><p>Social determinants of health (SDOH) are nonmedical factors that influence patient outcomes. This study aimed to determine the prevalence of randomized controlled trials (RCTs) reporting SDOH factors in their patient cohorts within several of the highest-impact spinal surgery journals. We hypothesize that SDOH factors will be infrequently reported and often miss variables such as socioeconomic status, employment status, insurance, and education level.</p><h3>Methods</h3><p>From 2020 to 2024, the PubMed database was queried to analyze spine RCTs reporting SDOHs from four high-impact journals. For each study, we determined the age, sex, and/or gender, body mass index (BMI), the year the article was published, the country of origin of the senior author, and self-reported SDOH factors. </p><h3>Results</h3><p> Of the 147 included RCTs, age (95.9%), sex/gender (94.6%), and BMI (72.8%) were reported by the majority of studies. There were a total of 33 countries represented by the RCTs reporting spine outcomes, where 25 (17.0%) RCTs were conducted in the United States, 22 (15.0%) RCTs conducted in China, 11 (7.5%) RCTs in the Netherlands, 9 (6.1%) RCTs in Japan and 9 (6.1%) RCTs in Turkey. </p><h3>Conclusion</h3><p> This paper provides valuable insights into the landscape of spine research and emphasizes the necessity of consistently reporting all SDOH factors. Future research can better inform clinical practice and policy decisions by addressing these considerations, ultimately improving healthcare outcomes for spine patients worldwide.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-026-06243-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147441495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1007/s00402-026-06221-7
Ahmed Aly, Tarek Aly
Background
Childhood obesity is a pressing global health issue with potential implications for musculoskeletal injury risk and recovery. Although the influence of obesity on bone metabolism is acknowledged, its specific connection to the incidence, patterns, and treatment results of long bone fractures in the pediatric demographic requires further clarification.
Purpose
This systematic review aims to evaluate the existing literature on the relationship between obesity and long bone fractures in children and adolescents, with a focus on fracture risk, anatomical distribution, management approaches, and clinical outcomes.
Methods
We conducted a systematic literature search of PubMed, MEDLINE, Cochrane Library, and Google Scholar for studies published from January 2000 to March 2025. Search terms included “childhood obesity”, “bone health”, and “long bone fractures”. We included English-language original research that analyzed the relationship between pediatric obesity (BMI ≥ 95th percentile) and long bone fractures. Data on study characteristics, fracture patterns, treatments, and outcomes were extracted.
Results
Out of 2,152 articles screened, 14 met the inclusion criteria. Children who were overweight or obese had higher odds of lower extremity fractures, particularly of the tibia and femur (odds ratios 1.5–3.3). Obesity was linked to more complex fracture patterns, including physical involvement and displacement, and a higher failure rate of nonsurgical management, especially for forearm and supracondylar fractures. Operative complications, such as varus deformity and pin-related issues, were more frequent in obese patients. However, no consistent differences were observed between obese and non-obese groups regarding mortality and long-term functional outcomes.
Conclusions
Pediatric obesity significantly elevates the risk and complexity of long bone fractures and complicates both nonoperative and surgical management. Acknowledging these challenges is crucial for optimizing treatment and preventing adverse outcomes. Further multicenter prospective studies are needed to clarify the underlying biomechanical and metabolic mechanisms and to guide the development of individualized management protocols.
{"title":"Obesity and long bone fractures in children. Systematic review","authors":"Ahmed Aly, Tarek Aly","doi":"10.1007/s00402-026-06221-7","DOIUrl":"10.1007/s00402-026-06221-7","url":null,"abstract":"<div><h3>Background</h3><p>Childhood obesity is a pressing global health issue with potential implications for musculoskeletal injury risk and recovery. Although the influence of obesity on bone metabolism is acknowledged, its specific connection to the incidence, patterns, and treatment results of long bone fractures in the pediatric demographic requires further clarification.</p><h3>Purpose</h3><p>This systematic review aims to evaluate the existing literature on the relationship between obesity and long bone fractures in children and adolescents, with a focus on fracture risk, anatomical distribution, management approaches, and clinical outcomes.</p><h3>Methods</h3><p>We conducted a systematic literature search of PubMed, MEDLINE, Cochrane Library, and Google Scholar for studies published from January 2000 to March 2025. Search terms included “childhood obesity”, “bone health”, and “long bone fractures”. We included English-language original research that analyzed the relationship between pediatric obesity (BMI ≥ 95th percentile) and long bone fractures. Data on study characteristics, fracture patterns, treatments, and outcomes were extracted.</p><h3>Results</h3><p>Out of 2,152 articles screened, 14 met the inclusion criteria. Children who were overweight or obese had higher odds of lower extremity fractures, particularly of the tibia and femur (odds ratios 1.5–3.3). Obesity was linked to more complex fracture patterns, including physical involvement and displacement, and a higher failure rate of nonsurgical management, especially for forearm and supracondylar fractures. Operative complications, such as varus deformity and pin-related issues, were more frequent in obese patients. However, no consistent differences were observed between obese and non-obese groups regarding mortality and long-term functional outcomes.</p><h3>Conclusions</h3><p>Pediatric obesity significantly elevates the risk and complexity of long bone fractures and complicates both nonoperative and surgical management. Acknowledging these challenges is crucial for optimizing treatment and preventing adverse outcomes. Further multicenter prospective studies are needed to clarify the underlying biomechanical and metabolic mechanisms and to guide the development of individualized management protocols.</p><h3>Level of evidence</h3><p>Systematic Review, Level III.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-026-06221-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06237-z
Josefa Stadelmeier, Filip Bijeljac, Alexander Klein, Felix Winden, Paul Reidler, Hans Roland Dürr
Introduction
Tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis (PVNS), involving the shoulder is extremely rare and can present with a challenging clinical course. Due to the complex anatomy of the shoulder, both diagnosis and treatment are demanding. This study aims to evaluate the diagnostic and therapeutic management of shoulder TGCT based on a case series and a review of the literature.
Materials and methods
Between 2005 and 2021, four patients (2 females, 2 males) with shoulder TGCT (1 localized, 3 diffuse) underwent surgical treatment at our institution. The minimum follow-up was 39 months (range: 39–233 months). Functional outcomes were assessed using the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), the Oxford Shoulder Score (OSS), and the Short Form 36 Health Survey (SF-36). Additionally, a literature review of 65 studies comprising 108 patients was performed.
Results
Treatments consisted of arthroscopic and open resections, tendon repair, adjuvant radiosynoviorthesis, and radiotherapy, as appropriate. All patients were recurrence-free at the last follow-up, except for one with stable residual disease after radiotherapy. The mean interval from symptom onset to diagnosis was 23.6 ± 28.1 months. In the literature cohort, the mean patient age was 50.3 ± 19.7 years, with a nearly equal gender distribution. Diffuse TGCT was more common (66.1%) than nodular TGCT (33.8%). Treatment was primarily surgery, arthroscopic (53.2%) or open (42.9%), with adjuvant therapies applied in 9.3% of cases. After a mean follow-up of 37.6 ± 36.2 months in 67 cases, diffuse in 44.8%, nodular in 19.4% (no data regarding TGCT-type in 35.8%) the reported recurrence rate was 10.6% and 4.5% remained with residual disease.
Conclusions
TGCT of the shoulder remains a rare and complex condition requiring individualized treatment strategies. Arthroscopic and open resections are the mainstays of therapy, while the role of adjuvant treatments should be carefully considered. Given the risk of recurrence, follow-up is essential. Further studies are needed to establish standardized treatment protocols and evaluate long-term outcomes.
{"title":"TGCT of the shoulder – a case series and literature review","authors":"Josefa Stadelmeier, Filip Bijeljac, Alexander Klein, Felix Winden, Paul Reidler, Hans Roland Dürr","doi":"10.1007/s00402-026-06237-z","DOIUrl":"10.1007/s00402-026-06237-z","url":null,"abstract":"<div><h3>Introduction</h3><p>Tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis (PVNS), involving the shoulder is extremely rare and can present with a challenging clinical course. Due to the complex anatomy of the shoulder, both diagnosis and treatment are demanding. This study aims to evaluate the diagnostic and therapeutic management of shoulder TGCT based on a case series and a review of the literature.</p><h3>Materials and methods</h3><p>Between 2005 and 2021, four patients (2 females, 2 males) with shoulder TGCT (1 localized, 3 diffuse) underwent surgical treatment at our institution. The minimum follow-up was 39 months (range: 39–233 months). Functional outcomes were assessed using the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), the Oxford Shoulder Score (OSS), and the Short Form 36 Health Survey (SF-36). Additionally, a literature review of 65 studies comprising 108 patients was performed.</p><h3>Results</h3><p>Treatments consisted of arthroscopic and open resections, tendon repair, adjuvant radiosynoviorthesis, and radiotherapy, as appropriate. All patients were recurrence-free at the last follow-up, except for one with stable residual disease after radiotherapy. The mean interval from symptom onset to diagnosis was 23.6 ± 28.1 months. In the literature cohort, the mean patient age was 50.3 ± 19.7 years, with a nearly equal gender distribution. Diffuse TGCT was more common (66.1%) than nodular TGCT (33.8%). Treatment was primarily surgery, arthroscopic (53.2%) or open (42.9%), with adjuvant therapies applied in 9.3% of cases. After a mean follow-up of 37.6 ± 36.2 months in 67 cases, diffuse in 44.8%, nodular in 19.4% (no data regarding TGCT-type in 35.8%) the reported recurrence rate was 10.6% and 4.5% remained with residual disease.</p><h3>Conclusions</h3><p>TGCT of the shoulder remains a rare and complex condition requiring individualized treatment strategies. Arthroscopic and open resections are the mainstays of therapy, while the role of adjuvant treatments should be carefully considered. Given the risk of recurrence, follow-up is essential. Further studies are needed to establish standardized treatment protocols and evaluate long-term outcomes.</p><h3>Level of evidence</h3><p>Level IV (Case series with no comparison group).</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06220-8
Ashok Rajgopal, Dhanasekara Raja Palanisami, Adarsh Annapareddy, Moin Khan, Raju Easwaran, Ashok Shyam, Sahil Sanghavi, Parag Sancheti
Introduction
Total knee arthroplasty (TKA) in obese patients poses multiple challenges and there is a lack of consensus on various aspects of TKA in this patient population. This study is a modified Delphi consensus study of international experts to provide recommendations on TKA in obese patients.
Materials and methods
The consensus statements were generated using an anonymized two-round modified Delphi questionnaire, sent to an international panel of 53 knee surgeons, with an 80% agreement being set as the limit for consensus. The responses were analysed using descriptive statistics, with median as the measure of central tendency. Anonymized feedback was provided to all panellists based on responses from previous rounds to help generate the consensus.
Results
9 statements reached a consensus: WHO classification (87%), BMI cut-off for single-stage bilateral TKA (92%), use of tibial stem (84%), medial parapatellar approach (92%), same surgical approach as non-obese TKA (92%), inherent malnutrition (82%), higher risk of aseptic loosening in BMI class 3 (81%), need for time interval between bilateral TKA (88%), and consensus against leaving the knee in slight flexion (82%). The panel was unable to reach a consensus on 17 statements.
Conclusion
This indicates lack of consensus on a majority of issues among experts and further research is required in this field to address evidence gaps, so we can improve our management of this increasing cohort of patients undergoing TKA. The statements reaching consensus form an important set of recommendation to improve patient selection and outcomes.
{"title":"Recommendations of an international Delphi study group for total knee arthroplasty in obese patients","authors":"Ashok Rajgopal, Dhanasekara Raja Palanisami, Adarsh Annapareddy, Moin Khan, Raju Easwaran, Ashok Shyam, Sahil Sanghavi, Parag Sancheti","doi":"10.1007/s00402-026-06220-8","DOIUrl":"10.1007/s00402-026-06220-8","url":null,"abstract":"<div><h3>Introduction</h3><p>Total knee arthroplasty (TKA) in obese patients poses multiple challenges and there is a lack of consensus on various aspects of TKA in this patient population. This study is a modified Delphi consensus study of international experts to provide recommendations on TKA in obese patients.</p><h3>Materials and methods</h3><p>The consensus statements were generated using an anonymized two-round modified Delphi questionnaire, sent to an international panel of 53 knee surgeons, with an 80% agreement being set as the limit for consensus. The responses were analysed using descriptive statistics, with median as the measure of central tendency. Anonymized feedback was provided to all panellists based on responses from previous rounds to help generate the consensus.</p><h3>Results</h3><p>9 statements reached a consensus: WHO classification (87%), BMI cut-off for single-stage bilateral TKA (92%), use of tibial stem (84%), medial parapatellar approach (92%), same surgical approach as non-obese TKA (92%), inherent malnutrition (82%), higher risk of aseptic loosening in BMI class 3 (81%), need for time interval between bilateral TKA (88%), and consensus against leaving the knee in slight flexion (82%). The panel was unable to reach a consensus on 17 statements.</p><h3>Conclusion</h3><p>This indicates lack of consensus on a majority of issues among experts and further research is required in this field to address evidence gaps, so we can improve our management of this increasing cohort of patients undergoing TKA. The statements reaching consensus form an important set of recommendation to improve patient selection and outcomes.</p><p><i>Level of evidence</i> Level V </p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06214-6
Muhammad Haider, Farouk Khury, Jonathan Katzman, Patrick Connolly, Anzar Sarfraz, Ran Schwarzkopf, Claudette M. Lajam
Background
The impact of liver cirrhosis on surgical outcomes is well-known. This study aimed to compare postoperative outcomes of total hip arthroplasty (THA) in patients with versus without cirrhosis.
Methods
A retrospective review was conducted of all patients who received a THA between 2012 and 2021 with a minimum of two years of clinical follow-up at a single, urban tertiary health center with lab results available to calculate Model for End-stage Liver Disease (MELD) scores. Using demographic variables, patients with and without cirrhosis underwent a 10:1 propensity score match. Short-term clinical outcomes were compared between cohorts. Cirrhotic patients were stratified based on their MELD score as mild (MELD < 10, n = 39) or moderate-to-severe (MELD ≥ 10, n = 10).
Results
Of the 539 patients included in this study, 49 patients were in the cirrhotic group and 490 patients were in the non-cirrhotic group. Compared to non-cirrhotic and mild cirrhotic, moderate-to-severe cirrhotic THA patients had significantly higher incidence of 30-day (2.9% vs. 2.6% vs. 30.0%, p = 0.011) and 90-day readmissions (5.9% vs. 2.6% vs. 30.0%, p = 0.038) due to periprosthetic joint infection (PJI), and higher incidence of 90-day (3.1% vs. 2.6% vs. 20.0%, p = 0.024) and all-time revisions (1.4% vs. 5.1% vs. 20.0%, p = 0.016) due to PJI. There were no differences in overall 90-day reoperation (p = 0.115) and revision risk (p = 0.202) between non-cirrhotic, mild cirrhotic, and moderate-to-severe cirrhotic THA patients. Freedom from all-cause reoperations/revisions did not differ significantly (p = 0.479) between non-cirrhotic and cirrhotic THA patients at 120 months of follow-up.
Conclusions
Cirrhotic patients, particularly those categorized as moderate-to-severe, undergoing THA may have higher risk of having a readmission or revision for PJI. However, overall 90-day readmission and revision risk were similar between non-cirrhotic and cirrhotic patients. Future research with larger sample sizes and databases is needed to further risk stratify, optimize and counsel cirrhosis patients surrounding THA.
{"title":"Comparing outcomes of total hip arthroplasty between cirrhotic and non-cirrhotic patients through a propensity-matched analysis","authors":"Muhammad Haider, Farouk Khury, Jonathan Katzman, Patrick Connolly, Anzar Sarfraz, Ran Schwarzkopf, Claudette M. Lajam","doi":"10.1007/s00402-026-06214-6","DOIUrl":"10.1007/s00402-026-06214-6","url":null,"abstract":"<div><h3>Background</h3><p>The impact of liver cirrhosis on surgical outcomes is well-known. This study aimed to compare postoperative outcomes of total hip arthroplasty (THA) in patients with versus without cirrhosis.</p><h3>Methods</h3><p>A retrospective review was conducted of all patients who received a THA between 2012 and 2021 with a minimum of two years of clinical follow-up at a single, urban tertiary health center with lab results available to calculate Model for End-stage Liver Disease (MELD) scores. Using demographic variables, patients with and without cirrhosis underwent a 10:1 propensity score match. Short-term clinical outcomes were compared between cohorts. Cirrhotic patients were stratified based on their MELD score as mild (MELD < 10, <i>n</i> = 39) or moderate-to-severe (MELD ≥ 10, <i>n</i> = 10).</p><h3>Results</h3><p>Of the 539 patients included in this study, 49 patients were in the cirrhotic group and 490 patients were in the non-cirrhotic group. Compared to non-cirrhotic and mild cirrhotic, moderate-to-severe cirrhotic THA patients had significantly higher incidence of 30-day (2.9% vs. 2.6% vs. 30.0%, <i>p</i> = 0.011) and 90-day readmissions (5.9% vs. 2.6% vs. 30.0%, <i>p</i> = 0.038) due to periprosthetic joint infection (PJI), and higher incidence of 90-day (3.1% vs. 2.6% vs. 20.0%, <i>p</i> = 0.024) and all-time revisions (1.4% vs. 5.1% vs. 20.0%, <i>p</i> = 0.016) due to PJI. There were no differences in overall 90-day reoperation (<i>p</i> = 0.115) and revision risk (<i>p</i> = 0.202) between non-cirrhotic, mild cirrhotic, and moderate-to-severe cirrhotic THA patients. Freedom from all-cause reoperations/revisions did not differ significantly (<i>p</i> = 0.479) between non-cirrhotic and cirrhotic THA patients at 120 months of follow-up.</p><h3>Conclusions</h3><p>Cirrhotic patients, particularly those categorized as moderate-to-severe, undergoing THA may have higher risk of having a readmission or revision for PJI. However, overall 90-day readmission and revision risk were similar between non-cirrhotic and cirrhotic patients. Future research with larger sample sizes and databases is needed to further risk stratify, optimize and counsel cirrhosis patients surrounding THA.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Immunological purification of rat precartilaginous stem cells and construction of the immortalized cell strain","authors":"Shuwei Zhang, Anmin Chen, Weihua Hu, Minghui Li, Hui Liao, Wentao Zhu, Dengxin Song, Fengjing Guo","doi":"10.1007/s00402-026-06231-5","DOIUrl":"10.1007/s00402-026-06231-5","url":null,"abstract":"","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06263-x
Damien Brochard, Maëlys Thepaut, Thomas Daoulas, Arthur Poiri, Hoel Letissier, Rémi Di Francia
Purpose
Proximal femur fractures primarily affect the elderly, with significant morbidity, mortality, and socioeconomic impact. The main complication of short trochanteric intramedullary nailing is the cut-out of the cervicocapital screw through the femoral head. The objective of this study was to analyze the influence of technical errors in short trochanteric intramedullary nailing for the treatment of trochanteric femur fractures on the mechanical failure of osteosynthesis.
Methods
A total of 540 patients who underwent surgery for a trochanteric femur fracture using short trochanteric intramedullary nailing were included in a single-center, retrospective study conducted between February 2012 and July 2018.
Results
Thirty patients (5.6%) experienced mechanical failure of the osteosynthesis at the 3-month follow-up. An anterior position of the cervicocapital screw, accumulation of technical errors, a tip-apex distance > 25 mm, and an intra-focal entry point were significantly associated with cervicocapital screw cut-out.
Conclusion
The mechanical failure rate is 5.6%. Short trochanteric intramedullary nailing requires precise execution to reduce the risk of cervicocapital screw cut-out, which is a source of osteosynthesis failure.
{"title":"The accumulation of technical errors exponentially increases the risk of screw cut-out in femoral intramedullary nailing","authors":"Damien Brochard, Maëlys Thepaut, Thomas Daoulas, Arthur Poiri, Hoel Letissier, Rémi Di Francia","doi":"10.1007/s00402-026-06263-x","DOIUrl":"10.1007/s00402-026-06263-x","url":null,"abstract":"<div><h3>Purpose</h3><p>Proximal femur fractures primarily affect the elderly, with significant morbidity, mortality, and socioeconomic impact. The main complication of short trochanteric intramedullary nailing is the cut-out of the cervicocapital screw through the femoral head. The objective of this study was to analyze the influence of technical errors in short trochanteric intramedullary nailing for the treatment of trochanteric femur fractures on the mechanical failure of osteosynthesis.</p><h3>Methods</h3><p>A total of 540 patients who underwent surgery for a trochanteric femur fracture using short trochanteric intramedullary nailing were included in a single-center, retrospective study conducted between February 2012 and July 2018.</p><h3>Results</h3><p>Thirty patients (5.6%) experienced mechanical failure of the osteosynthesis at the 3-month follow-up. An anterior position of the cervicocapital screw, accumulation of technical errors, a tip-apex distance > 25 mm, and an intra-focal entry point were significantly associated with cervicocapital screw cut-out.</p><h3>Conclusion</h3><p>The mechanical failure rate is 5.6%. Short trochanteric intramedullary nailing requires precise execution to reduce the risk of cervicocapital screw cut-out, which is a source of osteosynthesis failure.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06227-1
Ruoxuan Zhu, Maolin Wang, Juan Wang
Introduction
Despite the availability of various osteotomies for varus knee osteoarthritis, including proximal tibial, distal femoral, and fibular osteotomies, HTO is the most prevalent in clinical practice. The primary focus of this study is to investigate how distal femoral morphology influences the outcomes of HTO.
Methods
Demographic characteristics, radiographic parameters, and functional scores were collected preoperatively and at 2-year follow-up from patients undergoing HTO at our institution between January 2022 and July 2022. Patients were categorized into two cohorts based on the lateral distal femoral angle (LDFA): Group I (LDFA ≤ 89°) and Group II (LDFA > 89°). Each cohort was further stratified into three subgroups according to postoperative hip-knee-ankle angle (post-HKA): Subgroup A (HKA = 180° ± 0.5°), Subgroup B (HKA = 181° ± 0.5°), and Subgroup C (HKA = 182° ± 0.5°). Radiographic and functional outcomes were compared.
Results
The study included 191 patients distributed across six subgroups (IA: 33, IB:29, IC:29, IIA:37, IIB:30 and IIC:33). Significant inter-subgroup differences were observed in the change in joint line convergence angle (ΔJLCA) for both Group I (F = 11.876, P = 0.048) and Group II (F = 9.826, P = 0.042). ΔJLCA exhibited a positive correlation with the change in hip-knee-ankle angle (ΔHKA) in both groups (Group I: r = 0.323, P = 0.011; Group II: r = 0.522, P < 0.001). In Group I, postoperative joint line orientation angle (Post-JLOA) showed no significant differences. At 2-year follow-up, subgroup C demonstrated superiority in the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Oxford Knee Scores (OKS) compared to subgroup A(WOMAC:P = 0.006; OKS: P = 0.007). Changes in WOMAC and OKS (ΔWOMAC and ΔOKS) correlated positively with ΔHKA and ΔJLCA but showed no correlation with Post-JLOA. In Group II, Post-JLOA differed among the subgroups (F = 9.205, P = 0.035). At 2-year follow-up, Functional outcomes were comparable across subgroups. Both ΔWOMAC and ΔOKS positively correlated with ΔHKA and ΔJLCA but negatively with Post-JLOA.
Conclusion
A mechanical axis of 182° optimizes clinical outcomes in patients with normal femoral anatomy, while 180° is preferable for cases with distal femoral varus to minimize joint line obliquity.
尽管对于膝内翻性关节炎有多种截骨术,包括胫骨近端、股骨远端和腓骨截骨术,但HTO在临床实践中最为普遍。本研究的主要焦点是探讨股骨远端形态如何影响HTO的结果。方法收集2022年1月至2022年7月在我院接受HTO手术的患者术前和2年随访期间的人口统计学特征、影像学参数和功能评分。根据股骨外侧远端角度(LDFA)将患者分为两组:I组(LDFA≤89°)和II组(LDFA > 89°)。每个队列根据术后髋关节-膝关节-踝关节角度(HKA后)进一步分为三个亚组:A亚组(HKA = 180°±0.5°),B亚组(HKA = 181°±0.5°)和C亚组(HKA = 182°±0.5°)。比较影像学和功能预后。结果191例患者被分为6个亚组(IA: 33, IB:29, IC:29, IIA:37, IIB:30和IIC:33)。组I (F = 11.876, P = 0.048)和组II (F = 9.826, P = 0.042)关节线收敛角变化(ΔJLCA)亚组间差异有统计学意义。ΔJLCA与两组髋关节-膝关节-踝关节角度变化(ΔHKA)呈正相关(I组:r = 0.323, P = 0.011; II组:r = 0.522, P < 0.001)。组术后关节线定位角(Post-JLOA)差异无统计学意义。在2年的随访中,与A亚组相比,C亚组在西安大略省和麦克马斯特大学骨关节炎(WOMAC)和牛津膝关节评分(OKS)方面表现出优势(WOMAC:P = 0.006; OKS: P = 0.007)。WOMAC和OKS (ΔWOMAC和ΔOKS)的变化与ΔHKA和ΔJLCA呈正相关,但与jloa后无相关性。II组jloa后亚组间差异有统计学意义(F = 9.205, P = 0.035)。在2年的随访中,各亚组的功能结果具有可比性。ΔWOMAC、ΔOKS与ΔHKA、ΔJLCA呈正相关,与Post-JLOA呈负相关。结论股骨解剖正常患者机械轴为182°,股骨远端内翻患者机械轴为180°,可使关节线倾斜度最小。
{"title":"Impact of distal femoral morphology on short-term outcomes following high tibial osteotomy (HTO) in varus knees","authors":"Ruoxuan Zhu, Maolin Wang, Juan Wang","doi":"10.1007/s00402-026-06227-1","DOIUrl":"10.1007/s00402-026-06227-1","url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the availability of various osteotomies for varus knee osteoarthritis, including proximal tibial, distal femoral, and fibular osteotomies, HTO is the most prevalent in clinical practice. The primary focus of this study is to investigate how distal femoral morphology influences the outcomes of HTO.</p><h3>Methods</h3><p>Demographic characteristics, radiographic parameters, and functional scores were collected preoperatively and at 2-year follow-up from patients undergoing HTO at our institution between January 2022 and July 2022. Patients were categorized into two cohorts based on the lateral distal femoral angle (LDFA): Group I (LDFA ≤ 89°) and Group II (LDFA > 89°). Each cohort was further stratified into three subgroups according to postoperative hip-knee-ankle angle (post-HKA): Subgroup A (HKA = 180° ± 0.5°), Subgroup B (HKA = 181° ± 0.5°), and Subgroup C (HKA = 182° ± 0.5°). Radiographic and functional outcomes were compared.</p><h3>Results</h3><p>The study included 191 patients distributed across six subgroups (IA: 33, IB:29, IC:29, IIA:37, IIB:30 and IIC:33). Significant inter-subgroup differences were observed in the change in joint line convergence angle (ΔJLCA) for both Group I (F = 11.876, <i>P</i> = 0.048) and Group II (F = 9.826, <i>P</i> = 0.042). ΔJLCA exhibited a positive correlation with the change in hip-knee-ankle angle (ΔHKA) in both groups (Group I: r = 0.323, <i>P</i> = 0.011; Group II: r = 0.522, <i>P</i> < 0.001). In Group I, postoperative joint line orientation angle (Post-JLOA) showed no significant differences. At 2-year follow-up, subgroup C demonstrated superiority in the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Oxford Knee Scores (OKS) compared to subgroup A(WOMAC:<i>P</i> = 0.006; OKS: <i>P</i> = 0.007). Changes in WOMAC and OKS (ΔWOMAC and ΔOKS) correlated positively with ΔHKA and ΔJLCA but showed no correlation with Post-JLOA. In Group II, Post-JLOA differed among the subgroups (F = 9.205, <i>P</i> = 0.035). At 2-year follow-up, Functional outcomes were comparable across subgroups. Both ΔWOMAC and ΔOKS positively correlated with ΔHKA and ΔJLCA but negatively with Post-JLOA.</p><h3>Conclusion</h3><p>A mechanical axis of 182° optimizes clinical outcomes in patients with normal femoral anatomy, while 180° is preferable for cases with distal femoral varus to minimize joint line obliquity.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06242-2
Steffen Brodt, Sebastian Rohe, Philipp Knospe, Pablo Sanz-Ruiz, Georgi Wassilew, Georg Matziolis
Introduction
For cementless implantation of hip stems, it is very important that the original stem fits exactly into the femoral prosthesis bed previously shaped using a stem rasp. If the geometry of the stem rasp does not match the prosthesis geometry, this can result in either overstuffing or post-sintering of the original stem in relation to trial reduction with the stem rasp. Overstuffing results in leg lengthening, while subsidence of the stem results in shortening with the risk of dislocation and impingement. Trial reduction with the original stem and trial head can prevent this, but is associated with additional soft tissue trauma and a longer operating time.
Materials and methods
Three groups were prospectively randomized. Group 0 was treated with the Fitmore B stem and the conventional rasp system, Group 1 with the Optimys stem and Group 2 with the Fitmore B stem with a new, optimized rasp system via a minimally invasive posterolateral approach. Intraoperatively, the differences in leg length and offset between trial reduction with the stem rasp and the original stem were recorded using a hip navigation system.
Results
The conventional rasp system led to significant overstuffing (1.2 ± 0.5 mm, p = 0.024) with the Fitmore B stem, compared with the instruments of the Optimys stem. In contrast, the optimized rasp system with the Fitmore B stem resulted in an equally precise fit of the endoprosthesis to that achieved with Optimys.
Conclusion
There are relevant differences in the fit of rasp and original stem between different manufacturers and system evolutions. In order to ensure reproducible comparability of the fit of the original stem to the trial rasp, it is imperative that trial rasps are optimally adapted to the stems. This is an important way to avoid trial reduction after implantation of the original stem.
Trial registration
This study was registered in the German Clinical Trials Register (Deutsches Register Klinischer Studien) with the registration number DRKS00026749.
对于无骨水泥植入的髋关节干,非常重要的是,原始干完全适合股骨假体床先前使用干锉成形。如果柄锉的几何形状与假体的几何形状不匹配,这可能导致原始柄的填塞或后烧结,这与柄锉的试用减少有关。过度填充导致腿变长,而骨干下沉导致缩短,有脱位和撞击的风险。用原柄和试验头进行试验复位可以防止这种情况,但会造成额外的软组织损伤和更长的手术时间。材料与方法前瞻性随机分组。0组采用Fitmore B柄和传统的锉刀系统,1组采用Optimys柄,2组采用微创后外侧入路的Fitmore B柄和新的优化的锉刀系统。术中,使用髋关节导航系统记录试验复位与原始复位之间的腿长和偏移量的差异。结果与Optimys器械相比,常规锉制的Fitmore B器械出现明显的压塞现象(1.2±0.5 mm, p = 0.024)。相比之下,Fitmore B柄优化后的锉刀系统与Optimys实现了同样精确的假体配合。结论不同生产厂家、不同系统演进之间,棘轮与原杆的配合度存在相关差异。为了确保原始干与试验锉刀配合的可重复性可比性,必须使试验锉刀最佳地适应于茎。这是避免原茎植入术后试验减少的重要途径。试验注册本研究已在德国临床试验注册(Deutsches Register Klinischer studen)注册,注册号为DRKS00026749。
{"title":"Properly designed femoral stem impactors help to avoid overstuffing and make a second trial reduction unnecessary","authors":"Steffen Brodt, Sebastian Rohe, Philipp Knospe, Pablo Sanz-Ruiz, Georgi Wassilew, Georg Matziolis","doi":"10.1007/s00402-026-06242-2","DOIUrl":"10.1007/s00402-026-06242-2","url":null,"abstract":"<div><h3>Introduction</h3><p>For cementless implantation of hip stems, it is very important that the original stem fits exactly into the femoral prosthesis bed previously shaped using a stem rasp. If the geometry of the stem rasp does not match the prosthesis geometry, this can result in either overstuffing or post-sintering of the original stem in relation to trial reduction with the stem rasp. Overstuffing results in leg lengthening, while subsidence of the stem results in shortening with the risk of dislocation and impingement. Trial reduction with the original stem and trial head can prevent this, but is associated with additional soft tissue trauma and a longer operating time.</p><h3>Materials and methods</h3><p>Three groups were prospectively randomized. Group 0 was treated with the Fitmore B stem and the conventional rasp system, Group 1 with the Optimys stem and Group 2 with the Fitmore B stem with a new, optimized rasp system via a minimally invasive posterolateral approach. Intraoperatively, the differences in leg length and offset between trial reduction with the stem rasp and the original stem were recorded using a hip navigation system.</p><h3>Results</h3><p>The conventional rasp system led to significant overstuffing (1.2 ± 0.5 mm, <i>p</i> = 0.024) with the Fitmore B stem, compared with the instruments of the Optimys stem. In contrast, the optimized rasp system with the Fitmore B stem resulted in an equally precise fit of the endoprosthesis to that achieved with Optimys.</p><h3>Conclusion</h3><p>There are relevant differences in the fit of rasp and original stem between different manufacturers and system evolutions. In order to ensure reproducible comparability of the fit of the original stem to the trial rasp, it is imperative that trial rasps are optimally adapted to the stems. This is an important way to avoid trial reduction after implantation of the original stem.</p><h3>Trial registration</h3><p>This study was registered in the German Clinical Trials Register (Deutsches Register Klinischer Studien) with the registration number DRKS00026749.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00402-026-06262-y
Marlena Rose Mueller, Travis Cleland, Corrilynn O. Hileman, Andrew Olsen, Robert Wissner, Kimberley R. Monden
Introduction
Septic arthritis is a rare but devastating complication of intra-articular corticosteroid injection (CSI), associated with significant medical morbidity and poor clinical outcomes. Although previous studies have examined risks associated with CSI, few have tracked patients long-term. This study evaluates the incidence, timing, and patient characteristics related to iatrogenic septic arthritis within 6 months of receiving a large joint CSI, offering new insights to inform clinical practice.
Materials and methods
A retrospective, descriptive cohort study was conducted using SlicerDicer, a software stratification system within Epic, to identify patients diagnosed with septic arthritis within six months of receiving an intra-articular CSI of the hip, knee, or shoulder. Data were collected from a single institution over a 10-year period (July 1, 2010 to July 1, 2020). Individual chart review was used to obtain patient demographics, clinical characteristics, and procedural details for identified cases.
Results
Of 15,021 intra-articular corticosteroid injections performed, 14 cases of septic arthritis were identified within 6 months of the procedure, resulting in an incidence rate of 0.093%. Of the affected patients, 21% had underlying inflammatory arthritis, and 21% had underlying comorbidities resulting in immunosuppression. The median time to diagnosis was 3.5 (range 1–16) weeks post-injection, with a bimodal distribution of infections occurring primarily between 1 and 3 and 7–10 weeks post-injection. Staphylococcus aureus (42%) and coagulase-negative Staphylococcus species (36%) were the most commonly isolated organisms.
Conclusions
Large joint intra-articular CSI presents a low risk (< 0.1%) for developing septic arthritis, but can present up to 16 weeks post-injection. The preliminary observation of bimodal timing and delayed presentation of septic arthritis suggests that a standard two-week surveillance window may not be long enough to fully capture all infections, particularly those involving lower-virulence organisms. These findings highlight the need for informed risk stratification and prolonged vigilance well beyond the immediate post-injection period to identify infectious complications after large joint CSI.
{"title":"Septic arthritis following intra-articular corticosteroid injections: a retrospective analysis","authors":"Marlena Rose Mueller, Travis Cleland, Corrilynn O. Hileman, Andrew Olsen, Robert Wissner, Kimberley R. Monden","doi":"10.1007/s00402-026-06262-y","DOIUrl":"10.1007/s00402-026-06262-y","url":null,"abstract":"<div><h3>Introduction</h3><p>Septic arthritis is a rare but devastating complication of intra-articular corticosteroid injection (CSI), associated with significant medical morbidity and poor clinical outcomes. Although previous studies have examined risks associated with CSI, few have tracked patients long-term. This study evaluates the incidence, timing, and patient characteristics related to iatrogenic septic arthritis within 6 months of receiving a large joint CSI, offering new insights to inform clinical practice.</p><h3>Materials and methods</h3><p>A retrospective, descriptive cohort study was conducted using SlicerDicer, a software stratification system within Epic, to identify patients diagnosed with septic arthritis within six months of receiving an intra-articular CSI of the hip, knee, or shoulder. Data were collected from a single institution over a 10-year period (July 1, 2010 to July 1, 2020). Individual chart review was used to obtain patient demographics, clinical characteristics, and procedural details for identified cases.</p><h3>Results</h3><p>Of 15,021 intra-articular corticosteroid injections performed, 14 cases of septic arthritis were identified within 6 months of the procedure, resulting in an incidence rate of 0.093%. Of the affected patients, 21% had underlying inflammatory arthritis, and 21% had underlying comorbidities resulting in immunosuppression. The median time to diagnosis was 3.5 (range 1–16) weeks post-injection, with a bimodal distribution of infections occurring primarily between 1 and 3 and 7–10 weeks post-injection. <i>Staphylococcus aureus</i> (42%) and coagulase-negative <i>Staphylococcus</i> species (36%) were the most commonly isolated organisms.</p><h3>Conclusions</h3><p>Large joint intra-articular CSI presents a low risk (< 0.1%) for developing septic arthritis, but can present up to 16 weeks post-injection. The preliminary observation of bimodal timing and delayed presentation of septic arthritis suggests that a standard two-week surveillance window may not be long enough to fully capture all infections, particularly those involving lower-virulence organisms. These findings highlight the need for informed risk stratification and prolonged vigilance well beyond the immediate post-injection period to identify infectious complications after large joint CSI.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}