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The single antegrade sling graft: a novel hamstring autograft technique for combined anterior cruciate ligament and anterolateral ligament reconstruction 单顺行吊带移植:一种新的腘绳肌腱自体移植技术用于前交叉韧带和前外侧韧带联合重建。
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05697-5
Ahmed Rabie, Mohamed S. Arafa, Mahmoud Bahloul, Ahmed Abdelbadie

Introduction

As a result of increased incidence of anterior cruciate ligament (ACL) injury in young athletes, there is a rise in the indications surgical ACL reconstruction procedures. The value of anterolateral ligament (ALL) reconstruction emerges as a proposed solution to prevent graft failures and improve stability in this high demanding category of patients. The purpose of this study is to present our experience with a novel hamstring auto-grafting technique, the single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL using autologous gracilis (GR) and semitendinosus (ST) grafts utilizing a single femoral tunnel and double tibial tunnels.

Materials and methods

From January 2020 to December 2021, 21 soccer players were operated utilizing the SASG technique, a modification of the technique of SANTI study group. Inclusion criteria were participating in pivoting sport, high-grade pivot shift examination (Grade 2–3), and evidence of a lateral femoral notch sign or Segond's fracture on preoperative imaging. Patients were assessed for 2 years postoperatively by Lachman’s test for anteroposterior laxity and pivot shift test for rotational laxity. The postoperative outcomes were assessed by Tegner-Lysholm and International knee documentation committee scores. Also, the postoperative complications such as stiffness, infection and graft failure were reported.

Results

21 male soccer players with a mean age 26.4 years were included in this study. After 2 years follow up there was a statistically significant improvement in the both post-operative functional scores, P value < 0.001. Fifteen patients (71.4%) could return to their preoperative sport activity level with no giving-way symptoms. Only one case of graft failure was reported in the follow up.

Conclusions

The single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL yielded good results in terms of stability and return to sports. The technique is reproducible, and results are comparable to the available published literature.

简介:由于年轻运动员前交叉韧带(ACL)损伤发生率的增加,ACL重建手术的适应症有所增加。前外侧韧带(ALL)重建的价值是预防移植物失败和提高这类高要求患者稳定性的一种建议解决方案。本研究的目的是介绍一种新型腘绳肌腱自体移植技术的经验,即单顺行吊带移植(SASG),利用单股隧道和双胫骨隧道,利用自体股薄肌(GR)和半腱肌(ST)移植联合重建ACL和ALL。材料和方法:从2020年1月到2021年12月,21名足球运动员使用SASG技术进行手术,SASG技术是SANTI研究组技术的改进。纳入标准为参与旋转运动,高级别枢轴移位检查(2-3级),术前影像学显示股骨外侧切迹征象或Segond骨折。术后2年通过Lachman’s前后松弛试验和枢轴移位试验评估患者的旋转松弛。术后结果通过Tegner-Lysholm和国际膝关节文献委员会评分进行评估。术后出现僵硬、感染、移植物失败等并发症。结果:共纳入21名男性足球运动员,平均年龄26.4岁。经过2年的随访,两组术后功能评分P值均有统计学意义上的改善。结论:单顺行悬吊移植物(SASG)联合重建ACL和ALL,在稳定性和恢复运动能力方面均取得了良好的效果。该技术具有可重复性,结果与现有的已发表文献相当。
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引用次数: 0
Total joint arthroplasty of the thumb CMC joint 拇指CMC关节的全关节置换术。
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05663-1
Jiří Jurča, Martin Vlach, Vojtěch Havlas

Purpose of the study

Rhizarthrosis—osteoarthritis of the thumb carpometacarpal (CMC) joint is usually a primary idiopathic disease. Total joint arthroplasty (TJA) is one of the surgical treatment options for symptomatic advanced thumb CMC arthritis. This retrospective study aims to evaluate the mid-term functional and radiological results of TJA with the minimum follow-up period of 3 years after the surgery.

Material and methods

Presented are the results of 136 total trapeziometacarpal joint replacements in the group of 105 patients consisted of 96 women and 9 men. Used prostheses were ELiS® implant (27 cases), Ivory® implant (42 cases), Touch® Dual mobility (67 cases). The follow-up period was minimally 3 years postoperatively. In all the patients, along with range of motion and radiologic evaluation of implant position, the function and pain of operated joint were evaluated using DASH and VAS score at regular intervals pre- and postoperatively.

Results

At a mean of 85 months (range 38–126 months) post-operatively, patients in 116 cases (85%) reported full satisfaction and absence of symptoms and difficulties. In 12 cases (9%) some slight residual post-exercise pain was reported. In eight cases (6%) patients suffered from episodic rest-pain, but with a lower intensity than in the preoperative period. Postoperatively, the patients declared subjective improvement in hand function. The total DASH score and VAS score decreased in all patients, while ROM increased. The course of all of TJA surgeries was complication-free. Five patients needed revision surgery. In two patients a dislocation has occurred and in three cases a loosening of the cup’s implant was reported. The most frequent postoperative complication was the occurrence of transient paraesthesias of the thumb in eight cases (6%).

Conclusions

TJA is the method of choice in management of advanced symptomatic osteoarthritis of the thumb CMC joint. Mastering surgical technique, TJA represents safe and effective treatment method in advanced degenerative changes of the thumb CMC joint and it’s benefits exceed possible perioperative and postoperative risks.

研究目的:拇指腕掌骨(CMC)关节的根状关节病通常是一种原发性特发性疾病。全关节置换术(TJA)是有症状的晚期拇指CMC关节炎的手术治疗选择之一。本回顾性研究旨在评估TJA术后至少3年随访期的中期功能和影像学结果。材料和方法:本文报告了105例患者(96例女性,9例男性)136例全斜跖关节置换术的结果。使用的假体有ELiS®假体27例,Ivory®假体42例,Touch®双活动体67例。术后随访时间最短3年。所有患者术前、术后定期采用DASH评分和VAS评分对手术关节功能和疼痛进行评估,同时对关节活动范围和种植体位置进行影像学评估。结果:术后平均85个月(38-126个月),116例(85%)患者报告完全满意,无症状和困难。在12例(9%)中,报告了一些轻微的残余运动后疼痛。8例(6%)患者出现阵发性休息疼痛,但强度低于术前。术后,患者声称手功能主观改善。所有患者的总DASH评分和VAS评分均下降,ROM升高。所有TJA手术过程均无并发症。5例患者需要翻修手术。两例患者发生脱位,三例报告了假杯植入物松动。术后最常见的并发症是8例(6%)发生短暂性拇指感觉异常。结论:TJA是治疗晚期症状性拇指CMC关节骨性关节炎的首选方法。掌握手术技术,TJA是一种安全有效的治疗拇指CMC关节晚期退行性变的方法,其益处超过了围手术期和术后可能存在的风险。
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引用次数: 0
Presurgical anxiety and acute postsurgical pain predict worse chronic pain profiles after total knee/hip arthroplasty 术前焦虑和术后急性疼痛预示着全膝关节/髋关节置换术后更严重的慢性疼痛
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05681-z
Ana Cristina Paredes, Patrício Costa, Armando Almeida, Patrícia R. Pinto

Introduction

Total joint arthroplasties generally achieve good outcomes, but chronic pain and disability are a significant burden after these interventions. Acknowledging relevant risk factors can inform preventive strategies. This study aimed to identify chronic pain profiles 6 months after arthroplasty using the ICD-11 (International Classification of Diseases) classification and to find pre and postsurgical predictors of these profiles.

Materials and methods

Patients undergoing total knee/hip arthroplasty (n = 209, female = 54.5%) were assessed before surgery, 48 h and 6 months postsurgery for sociodemographic, pain-related, disability and psychological characteristics. K-means-constrained cluster analysis identified chronic pain profiles based on 6-month pain intensity, pain interference and disability. Chi-square tests or one-way ANOVA explored between-cluster differences. Multinomial regression identified predictors of cluster membership. Separate models analyzed presurgical (model 1), postsurgical (model 2) and a combination of previously significant pre and postsurgical (model 3) variables.

Results

A three-cluster solution was selected, translating increasingly worse chronic pain severity: cluster 1 (C1, n = 129), cluster 2 (C2, n = 60) and cluster 3 (C3, n = 20). There were presurgical differences among clusters in the presence of other painful sites (p = 0.013, ϕc = 0.20), pain interference (p = 0.038, η2 = 0.031), disability (p = 0.020, η2 = 0.037), pain catastrophizing (p = 0.019, η2 = 0.060), anxiety (p < 0.001, η2 = 0.087), depression (p = 0.017; η2 = 0.039), self-efficacy (p = 0.018, η2 = 0.038) and satisfaction with life (p = 0.034, η2 = 0.032), postsurgical pain frequency (p = 0.003, ϕc = 0.243) and intensity (p < 0.001, η2 = 0.101). In model 1, disability predicted C2 (OR = 1.040) and anxiety predicted C3 (OR = 1.154) membership. In model 2, pain intensity predicted C3 (OR = 1.690) membership. In model 3, presurgical anxiety predicted C3 (OR = 1.181) and postsurgical pain intensity predicted C2 (OR = 1.234) and C3 (OR = 1.679) membership.

Conclusions

Most patients had low chronic pain severity at 6 months, but a relevant percentage exhibited poor outcomes. Membership to different outcome profiles was predicted by presurgical anxiety and acute postsurgical pain. These seem promising targets to prevent pain chronification that should be optimized for better surgical outcomes.

全关节置换术通常取得良好的效果,但慢性疼痛和残疾是这些干预后的重大负担。承认相关的风险因素可以为预防战略提供信息。本研究旨在利用ICD-11(国际疾病分类)分类确定关节置换术后6个月的慢性疼痛情况,并寻找这些情况的术前和术后预测因素。材料与方法对接受全膝关节/髋关节置换术的患者(209例,女性54.5%)术前、术后48小时和6个月的社会人口学、疼痛相关、残疾和心理特征进行评估。k均值约束聚类分析确定了基于6个月疼痛强度、疼痛干扰和残疾的慢性疼痛概况。卡方检验或单因素方差分析探讨了聚类之间的差异。多项回归确定了聚类隶属度的预测因子。单独的模型分析术前(模型1)、术后(模型2)以及先前重要的术前和术后(模型3)变量的组合。结果选择了三组解决方案,慢性疼痛程度逐渐加重:1组(C1, n = 129)、2组(C2, n = 60)和3组(C3, n = 20)。手术前存在其他疼痛部位(p = 0.013, ϕc = 0.20)、疼痛干扰(p = 0.038, η2 = 0.031)、残疾(p = 0.020, η2 = 0.037)、疼痛灾难化(p = 0.019, η2 = 0.060)、焦虑(p < 0.001, η2 = 0.087)、抑郁(p = 0.017;η2 = 0.039)、自我效能感(p = 0.018, η2 = 0.038)、生活满意度(p = 0.034, η2 = 0.032)、术后疼痛频率(p = 0.003, η c = 0.243)、疼痛强度(p < 0.001, η2 = 0.101)。在模型1中,残疾预测C2 (OR = 1.040),焦虑预测C3 (OR = 1.154)。在模型2中,疼痛强度预测C3隶属度(OR = 1.690)。在模型3中,术前焦虑预测C3 (OR = 1.181),术后疼痛强度预测C2 (OR = 1.234)和C3 (OR = 1.679)。结论大多数患者在6个月时慢性疼痛严重程度较低,但相关比例的患者预后较差。通过术前焦虑和术后急性疼痛来预测不同的预后概况。这些似乎有希望的目标,以防止疼痛的慢性化,应该优化更好的手术结果。
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引用次数: 0
Diabesity is associated with a worse joint specific functional outcome following primary total knee replacement 糖尿病与原发性全膝关节置换术后较差的关节特定功能结果相关
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05704-9
Jack Lovie, Nicholas D. Clement, Deborah MacDonald, Issaq Ahmed

Introduction

The combined effect of diabetes mellitus and obesity (Diabesity) on total knee replacement (TKR) outcomes is unclear. This study aimed to assess whether diabesity influenced functional outcomes and complication rate following primary TKR.

Materials and methods

This case-controlled study compared the independent effects of obesity, diabetes, and diabesity on TKR outcomes. Data were collected pre-operatively and 12 months post-operatively from a single study centre. Outcomes included Oxford Knee Score (OKS), EuroQol 5-dimensions (Eq. 5D), post-operative satisfaction and complication rate.

Results

There were 2577 TKRs in the cohort, of which 244 (9.5%) had diabesity. Diabesity was independently associated with reduced pre-operative OKS (-1.14 points, 95% CI -1.97 to -0.31, p = 0.007) and OKS improvement (-2.37 points, 95% CI -3.11 to -1.62, p < 0.001). Obesity was also independently associated with worse pre-operative OKS (-0.78 points, 95% CI -1.28 to -0.27, p = 0.003) and OKS improvement (-0.81 points, 95% CI -1.26 to -0.35, p = 0.001). Both diabesity (-0.05 points, 95% CI -0.08 to -0.02, p = 0.003) and obesity (-0.02 points, 95% CI -0.04 to 0.00, p = 0.039) were associated with worse pre-operative Eq. 5D score. Patients with diabesity reported reduced post-operative satisfaction due to obesity independently (OR 0.75, 95% CI 0.56 to 1.00, p = 0.048). Diabesity was not independently associated with post-operative complications.

Conclusions

Diabesity was independently associated with a worse knee-specific function and Eq. 5D score pre-operatively, and diminished joint specific functional improvement following TKR. Patients with diabesity also experienced reduced post-operative satisfaction due to obesity independently.

糖尿病和肥胖症对全膝关节置换术(TKR)预后的综合影响尚不清楚。本研究旨在评估糖尿病是否影响原发性TKR后的功能结局和并发症发生率。材料和方法本病例对照研究比较了肥胖、糖尿病和糖尿病对TKR结果的独立影响。术前和术后12个月从一个研究中心收集数据。结果包括牛津膝关节评分(OKS)、EuroQol 5维度(Eq. 5D)、术后满意度和并发症发生率。结果本组2577例tkr患者中有糖尿病患者244例(9.5%)。糖尿病与术前OKS降低(-1.14分,95% CI -1.97 ~ -0.31, p = 0.007)和OKS改善(-2.37分,95% CI -3.11 ~ -1.62, p < 0.001)独立相关。肥胖还与术前OKS恶化(-0.78点,95% CI -1.28 ~ -0.27, p = 0.003)和OKS改善(-0.81点,95% CI -1.26 ~ -0.35, p = 0.001)独立相关。糖尿病(-0.05点,95% CI -0.08 ~ -0.02, p = 0.003)和肥胖(-0.02点,95% CI -0.04 ~ 0.00, p = 0.039)与术前Eq. 5D评分较差相关。糖尿病患者报告术后满意度因肥胖而降低(OR 0.75, 95% CI 0.56 ~ 1.00, p = 0.048)。糖尿病与术后并发症无独立相关性。结论糖尿病与术前膝关节特异性功能和Eq. 5D评分恶化以及TKR后关节特异性功能改善减弱独立相关。糖尿病患者的术后满意度也因肥胖而降低。
{"title":"Diabesity is associated with a worse joint specific functional outcome following primary total knee replacement","authors":"Jack Lovie,&nbsp;Nicholas D. Clement,&nbsp;Deborah MacDonald,&nbsp;Issaq Ahmed","doi":"10.1007/s00402-024-05704-9","DOIUrl":"10.1007/s00402-024-05704-9","url":null,"abstract":"<div><h3>Introduction</h3><p>The combined effect of diabetes mellitus and obesity (Diabesity) on total knee replacement (TKR) outcomes is unclear. This study aimed to assess whether diabesity influenced functional outcomes and complication rate following primary TKR.</p><h3>Materials and methods</h3><p>This case-controlled study compared the independent effects of obesity, diabetes, and diabesity on TKR outcomes. Data were collected pre-operatively and 12 months post-operatively from a single study centre. Outcomes included Oxford Knee Score (OKS), EuroQol 5-dimensions (Eq. 5D), post-operative satisfaction and complication rate.</p><h3>Results</h3><p>There were 2577 TKRs in the cohort, of which 244 (9.5%) had diabesity. Diabesity was independently associated with reduced pre-operative OKS (-1.14 points, 95% CI -1.97 to -0.31, <i>p</i> = 0.007) and OKS improvement (-2.37 points, 95% CI -3.11 to -1.62, <i>p</i> &lt; 0.001). Obesity was also independently associated with worse pre-operative OKS (-0.78 points, 95% CI -1.28 to -0.27, <i>p</i> = 0.003) and OKS improvement (-0.81 points, 95% CI -1.26 to -0.35, <i>p</i> = 0.001). Both diabesity (-0.05 points, 95% CI -0.08 to -0.02, <i>p</i> = 0.003) and obesity (-0.02 points, 95% CI -0.04 to 0.00, <i>p</i> = 0.039) were associated with worse pre-operative Eq. 5D score. Patients with diabesity reported reduced post-operative satisfaction due to obesity independently (OR 0.75, 95% CI 0.56 to 1.00, <i>p</i> = 0.048). Diabesity was not independently associated with post-operative complications.</p><h3>Conclusions</h3><p>Diabesity was independently associated with a worse knee-specific function and Eq. 5D score pre-operatively, and diminished joint specific functional improvement following TKR. Patients with diabesity also experienced reduced post-operative satisfaction due to obesity independently.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic packing – status 2024 骨盆填塞-现状2024
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05699-3
Axel Gänsslen, Tim Pohlemann, Jan Lindahl, Jan Erik Madsen

Patients with unstable hemodynamics and unstable pelvic ring injuries are still demanding patients regarding initial treatment and survival. Several concepts were reported during the last 30 years. Mechanical stabilization of the pelvis together with hemorrhage control offer the best treatment option in these patients. While pelvic ring stabilization using pelvic binders, external fixators and the pelvic C-clamp are the basis for mechanical stability of the pelvic ring, the optimal modality for pelvic bleeding control is still under discussion. Beside angioembolization (AE) and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), pelvic packing PP (predominantly extraperitoneal) with direct access to the pelvic bleeding sources, are potential options. The present overview represents the present status, results and the value of pelvic packing in treating these patients. Interpretation of these results must consider the difference between the initial European concept of pelvic ring stabilization followed by PP in contrast to the North American concept with a reduced rate of pelvic ring stabilizations.

不稳定血流动力学和不稳定骨盆环损伤的患者在初始治疗和生存方面仍然需要患者。在过去的30年里,有几个概念被报道出来。骨盆的机械稳定和出血控制是这些患者的最佳治疗选择。虽然使用骨盆固定器、外固定架和骨盆c型钳稳定骨盆环是骨盆环机械稳定的基础,但控制骨盆出血的最佳方式仍在讨论中。除了血管栓塞术(AE)和复苏性血管内球囊主动脉闭塞术(REBOA)外,直接进入盆腔出血源的骨盆填塞PP(主要是腹膜外填塞)也是潜在的选择。本文概述了骨盆填充物在治疗这些患者中的现状、结果和价值。对这些结果的解释必须考虑到欧洲最初的骨盆环稳定概念与PP之后的骨盆环稳定率降低的北美概念之间的差异。
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引用次数: 0
Differential effects of tibia varus deformity on clinical outcomes following high tibial osteotomy and unicompartmental knee arthroplasty for moderate medial compartment osteoarthritis with moderate varus alignment 胫骨内翻畸形对胫骨高位截骨和单室膝关节置换术治疗中度内翻对齐的中度骨关节炎临床结果的不同影响
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05718-3
Jun-Gu Park, Seung-Beom Han, Ki-Mo Jang, Seung-Min Shin

Introduction

There is a lack of clinical evidence supporting the decision-making process between high tibial osteotomy (HTO) and unicomparmental knee arthroplasty (UKA) in gray zone indication, such as moderate medial osteoarthritis with moderate varus alignment. This study compared the outcomes between HTO and UKA in such cases and assessed the risk factor for not maintaining clinical improvements.

Materials and methods

We retrospectively reviewed 65 opening-wedge HTOs and 55 UKAs with moderate medial osteoarthritis (Kellgren-Lawrence grade ≥ 3 and Ahlback grade < 3) and moderate varus alignment (5°< Hip-Knee-Ankle angle < 10°) over 3 years follow-up. Confounding factors including patient demographics, postoperative lower limb alignment was assessed. Dummy variable was used to categorize the HTO and UKA according to presence of tibia varus deformity (medial proximal tibial angle of 85°). Clinical outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score preoperatively, 1 year postoperatively, and at the last follow-up. Cox regression analysis identified risk factors for not achieving minimal clinically important differences (MCID) in WOMAC scores.

Results

The WOMAC score at 1-postoperative year significantly improved beyond MCID in all UKA and HTO. However, over a mean follow-up of 68.7 months (HTO) and 64.3 months (UKA), 16 patients (13.3%) experienced clinical deterioration. Notably, patients with suboptimal postoperative alignment, those undergoing HTO without tibial vara, and UKA with tibial vara had higher risks of clinical deterioration during the mid-term period.

Conclusion

Tibial varus deformity differentially affects clinical outcomes after HTO and UKA in moderate medial compartment osteoarthritis with moderate varus alignment. Clinicians should consider the deformity’s origin when selecting treatment for this patient, as certain combinations (HTO without tibia vara and UKA with tibia vara) are associated with increased risk of not maintaining mid-term clinical improvements.

在灰色地带适应症中,如中度内翻对齐的中度内侧骨关节炎,缺乏临床证据支持在高位胫骨截骨术(HTO)和单间膝关节置换术(UKA)之间的决策过程。本研究比较了HTO和UKA在这种情况下的结果,并评估了不能维持临床改善的风险因素。材料和方法我们回顾性分析了65例开放式楔形hto和55例uka患者的中度内侧骨关节炎(kelgren - lawrence分级≥3级和Ahlback分级<; 3)和中度内翻对准(5°<;髋关节-膝关节-踝关节角(10°),随访3年。混杂因素包括患者人口统计学,术后下肢对齐进行评估。根据是否存在胫骨内翻畸形(胫骨内侧近端角85°),使用虚拟变量对HTO和UKA进行分类。临床结果采用术前、术后1年和最后一次随访时的西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分进行测量。Cox回归分析确定了WOMAC评分未达到最小临床重要差异(MCID)的危险因素。结果所有UKA和HTO术后1年WOMAC评分均显著高于MCID。然而,在平均68.7个月(HTO)和64.3个月(UKA)的随访中,16例患者(13.3%)出现临床恶化。值得注意的是,术后排列不理想的患者、无胫骨内翻的HTO患者和有胫骨内翻的UKA患者在中期临床恶化的风险更高。结论胫骨内翻畸形对中度内翻线型中度内翻骨关节炎HTO和UKA术后的临床疗效有不同的影响。临床医生在为该患者选择治疗方法时应考虑畸形的来源,因为某些组合(无胫骨内翻的HTO和有胫骨内翻的UKA)与不能维持中期临床改善的风险增加有关。
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引用次数: 0
Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: a systematic review 精确医学在骨和软组织肉瘤的诊断、预后和疾病监测中使用液体活检:系统回顾
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05711-w
Maria Anna Smolle, Markus G. Seidel, Karl Kashofer, Bernadette Liegl-Atzwanger, Patrick Sadoghi, Daniel A. Müller, Andreas Leithner

Introduction

Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms.

Materials and methods

A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas.

Results

Overall, data on clinical applicability of liquid biopsy in 2636 patients with > 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively.

Conclusions

This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.

多年来,液体活检作为一种非侵入性的癌症生物学研究和残留疾病监测方法在临床实践中具有重要意义。虽然它在癌症中的适用性已经得到了很好的确立,但骨和软组织肉瘤的低发病率和异质性解释了在这些高度恶性的间充质肿瘤中考虑液体活检的不太完善的知识。材料和方法根据PRISMA指南进行的系统性文献综述初步确定了920项研究,其中68篇原创文章最终被纳入,这些研究均涉及肉瘤液体活检的临床适用性。研究分为两个主要章节,即易位相关肉瘤和复杂核型肉瘤。结果总结了10种不同类型骨软组织肉瘤2636例患者液体活检的临床适用性数据。5种最常见的肿瘤包括骨肉瘤(602例)、尤文氏肉瘤(384例)、胃肠道间质瘤(GIST;N = 203),横纹肌肉瘤(N = 193)和平滑肌肉瘤(N = 145)。在11项液体活检分析中,ctDNA和cfDNA的证据最多,分别在26项和18项研究中进行了调查。本系统的文献综述提供了广泛的最新综述,介绍了不同液体活检方式作为肉瘤诊断、预后和疾病监测标志物的当前和潜在的未来应用。
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引用次数: 0
Functional outcomes after ankle fracture-dislocation: a systematic review 踝关节骨折脱位后的功能结局:系统回顾
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05643-5
Helena F. Barber, Zachary D. Randall, Matthew J. Strok, Jake H. Goldfarb, Lauren Yaeger, Marschall B. Berkes

Introduction

Ankle fractures represent a significant portion of orthopedic injuries, with fracture dislocations tending to have worse outcomes. Logsplitter fractures represent a subset of fracture dislocations in which the talus is axially wedged in the tibiofibular joint. We aim to comprehensively investigate and report on the complications and functional outcomes associated with ankle fracture-dislocations.

Materials and Methods

Following PRISMA guidelines, a medical librarian conducted a literature search in Embase, Ovid Medline, Scopus, Cochrane Central Register of Controlled Trials, and The Cochrane Database of Systematic Reviews. Studies examining ankle fracture-dislocations and reporting on functional or employment outcomes were included. Excluded were non-English studies, abstracts, conference proceedings, letters, perspective pieces, reviews, editorials, and case reports or series with fewer than five patients. Data on functional outcomes were extracted and reported using descriptive statistics. A comparative analysis of AOFAS scores between Logsplitter and ankle fracture-dislocations was conducted using pooled means and independent t-tests.

Results

A total of 21 studies involving 810 cases of ankle fracture-dislocations were included. The pooled mean AOFAS score across 13 studies was 81.5, indicating “good” outcomes, while Logsplitter injuries had a significantly lower mean score of 75.8 compared to 82.9 for other ankle fracture-dislocations (p = 0.016). Complications included wound infection (7.3%), posttraumatic osteoarthritis (29.2%), nonunion/malunion (12.6%), and malunion. No studies reported on employment outcomes.

Conclusions

Ankle fracture-dislocations are high-energy injuries that affect a younger population compared to non-dislocated ankle fractures. Their functional outcomes resemble those of pilon fractures more than common ankle fractures. Logsplitter injuries are a subset of fracture dislocations that occur in even younger patients, with worse functional outcomes. This information can guide perioperative discussion and expectations for functional recovery. Additional studies are needed to evaluate the impact of these injuries on return to employment.

踝关节骨折是骨科损伤的重要组成部分,骨折脱位往往有较差的预后。Logsplitter骨折是骨折脱位的一个子集,其中距骨轴向楔入胫腓骨关节。我们的目的是全面调查和报道与踝关节骨折脱位相关的并发症和功能结局。材料和方法根据PRISMA指南,一位医学图书管理员在Embase、Ovid Medline、Scopus、Cochrane Central Register of Controlled Trials和Cochrane system Reviews数据库中进行了文献检索。研究检查踝关节骨折脱位并报告功能或就业结果。排除非英语研究、摘要、会议记录、信件、透视片、评论、社论、病例报告或少于5例患者的系列。功能结果的数据提取和报告使用描述性统计。采用合并均值和独立t检验对Logsplitter和踝关节骨折脱位的AOFAS评分进行比较分析。结果共纳入21篇研究,涉及踝关节骨折脱位810例。13项研究的综合平均AOFAS评分为81.5分,表明“良好”的结果,而Logsplitter损伤的平均评分为75.8分,明显低于其他踝关节骨折脱位的82.9分(p = 0.016)。并发症包括伤口感染(7.3%)、创伤后骨关节炎(29.2%)、不愈合/不愈合(12.6%)和不愈合。没有关于就业结果的研究报告。结论踝关节骨折脱位是一种高能量损伤,与非脱位的踝关节骨折相比,影响的人群更年轻。他们的功能结果更类似于头枕骨折,而不是普通的踝关节骨折。劈裂伤是骨折脱位的一个子集,发生在更年轻的患者中,功能预后更差。这些信息可以指导围手术期的讨论和对功能恢复的期望。需要进一步的研究来评估这些伤害对重返就业的影响。
{"title":"Functional outcomes after ankle fracture-dislocation: a systematic review","authors":"Helena F. Barber,&nbsp;Zachary D. Randall,&nbsp;Matthew J. Strok,&nbsp;Jake H. Goldfarb,&nbsp;Lauren Yaeger,&nbsp;Marschall B. Berkes","doi":"10.1007/s00402-024-05643-5","DOIUrl":"10.1007/s00402-024-05643-5","url":null,"abstract":"<div><h3>Introduction</h3><p>Ankle fractures represent a significant portion of orthopedic injuries, with fracture dislocations tending to have worse outcomes. Logsplitter fractures represent a subset of fracture dislocations in which the talus is axially wedged in the tibiofibular joint. We aim to comprehensively investigate and report on the complications and functional outcomes associated with ankle fracture-dislocations.</p><h3>Materials and Methods</h3><p>Following PRISMA guidelines, a medical librarian conducted a literature search in Embase, Ovid Medline, Scopus, Cochrane Central Register of Controlled Trials, and The Cochrane Database of Systematic Reviews. Studies examining ankle fracture-dislocations and reporting on functional or employment outcomes were included. Excluded were non-English studies, abstracts, conference proceedings, letters, perspective pieces, reviews, editorials, and case reports or series with fewer than five patients. Data on functional outcomes were extracted and reported using descriptive statistics. A comparative analysis of AOFAS scores between Logsplitter and ankle fracture-dislocations was conducted using pooled means and independent t-tests.</p><h3>Results</h3><p>A total of 21 studies involving 810 cases of ankle fracture-dislocations were included. The pooled mean AOFAS score across 13 studies was 81.5, indicating “good” outcomes, while Logsplitter injuries had a significantly lower mean score of 75.8 compared to 82.9 for other ankle fracture-dislocations (<i>p</i> = 0.016). Complications included wound infection (7.3%), posttraumatic osteoarthritis (29.2%), nonunion/malunion (12.6%), and malunion. No studies reported on employment outcomes.</p><h3>Conclusions</h3><p>Ankle fracture-dislocations are high-energy injuries that affect a younger population compared to non-dislocated ankle fractures. Their functional outcomes resemble those of pilon fractures more than common ankle fractures. Logsplitter injuries are a subset of fracture dislocations that occur in even younger patients, with worse functional outcomes. This information can guide perioperative discussion and expectations for functional recovery. Additional studies are needed to evaluate the impact of these injuries on return to employment.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous hallux fusion with calcaneus bone autograft: a retrospective cohort study of clinical and radiographic outcomes 经皮拇趾融合自体跟骨移植:临床和影像学结果的回顾性队列研究
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05613-x
Marco Minelli, Alirio J. deMeireles, Gerard F. Marciano, Bonnie Y. Chien, Mahant Malempati, Ettore Vulcano

Background

In the case of end-stage hallux rigidus, first metatarsophalangeal (MTP) joint arthrodesis is the gold-standard and is traditionally performed via an open approach. However, complications such as nonunion have been reported to be as high as 30%. Recently, there have been reports demonstrating a percutaneous approach to be effective and safe.

Methods

Forty-nine patients with end-stage hallux rigidus underwent percutaneous first MTP joint arthrodesis with calcaneus autograft performed by a single surgeon. Each patient underwent a minimum of 24 month clinical and radiographic follow up, including 3 month post operative computed tomography scans. Clinical outcomes were assessed using the Visual Analog Scale (VAS) and Foot Function Index (FFI) preoperatively and at final follow-up.

Results

Mean follow-up was 27.3 months. Bone union was observed in 46 patients (93.9%). Mean time to union was 3.1 months. Nonunion rate was 6.1%. Overall complication rate was 12.2%. Mean pre- and postoperative VAS scores were 7.5 and 0.2, respectively (P < .0001). Mean pre- and postoperative total FFI values were 56.3 and 15.7 (P < .0001), respectively. Patient satisfaction after the procedure was 93.9%.

Conclusion

Observed union rate is comparable to the average fusion rate previously reported for open and minimally invasive procedure union rates. Mean time to union was observed to be comparable to open procedures union time. Observed overall complication rate is similar to those reported for open techniques as well. Patient reported outcomes demonstrated a significant reduction in postoperative VAS and FFI for the percutaneous metatarsophalangeal arthrodesis with calcaneus bone autograft. Patient satisfaction rates compared favorably to those reported following open surgery.

Level of evidence.

Level IV.

背景:在终末期拇趾僵直的病例中,第一跖趾(MTP)关节融合术是金标准,传统上通过开放入路进行。然而,诸如骨不连之类的并发症据报道高达30%。最近,有报道表明经皮入路是有效和安全的。方法对49例终末期拇僵直患者行自体跟骨植入术。每位患者接受了至少24个月的临床和影像学随访,包括术后3个月的计算机断层扫描。采用视觉模拟量表(VAS)和足部功能指数(FFI)对术前和最终随访的临床结果进行评估。结果平均随访27.3个月。骨愈合46例(93.9%)。平均合并时间3.1个月。不愈合率为6.1%。总并发症发生率为12.2%。术前和术后平均VAS评分分别为7.5和0.2 (P < .0001)。术前和术后总FFI平均值分别为56.3和15.7 (P < .0001)。术后患者满意度为93.9%。结论观察到的愈合率与先前报道的开放和微创手术愈合率的平均融合率相当。观察到平均愈合时间与开放手术愈合时间相当。观察到的总并发症发生率与报道的开放式手术相似。患者报告的结果显示,自体跟骨经皮跖趾融合术术后VAS和FFI显著降低。患者满意率与开放手术后的报告相比较有利。证据水平。IV级。
{"title":"Percutaneous hallux fusion with calcaneus bone autograft: a retrospective cohort study of clinical and radiographic outcomes","authors":"Marco Minelli,&nbsp;Alirio J. deMeireles,&nbsp;Gerard F. Marciano,&nbsp;Bonnie Y. Chien,&nbsp;Mahant Malempati,&nbsp;Ettore Vulcano","doi":"10.1007/s00402-024-05613-x","DOIUrl":"10.1007/s00402-024-05613-x","url":null,"abstract":"<div><h3>Background</h3><p>In the case of end-stage hallux rigidus, first metatarsophalangeal (MTP) joint arthrodesis is the gold-standard and is traditionally performed via an open approach. However, complications such as nonunion have been reported to be as high as 30%. Recently, there have been reports demonstrating a percutaneous approach to be effective and safe.</p><h3>Methods</h3><p>Forty-nine patients with end-stage hallux rigidus underwent percutaneous first MTP joint arthrodesis with calcaneus autograft performed by a single surgeon. Each patient underwent a minimum of 24 month clinical and radiographic follow up, including 3 month post operative computed tomography scans. Clinical outcomes were assessed using the Visual Analog Scale (VAS) and Foot Function Index (FFI) preoperatively and at final follow-up.</p><h3>Results</h3><p>Mean follow-up was 27.3 months. Bone union was observed in 46 patients (93.9%). Mean time to union was 3.1 months. Nonunion rate was 6.1%. Overall complication rate was 12.2%. Mean pre- and postoperative VAS scores were 7.5 and 0.2, respectively (<i>P</i> &lt; .0001). Mean pre- and postoperative total FFI values were 56.3 and 15.7 (<i>P</i> &lt; .0001), respectively. Patient satisfaction after the procedure was 93.9%.</p><h3>Conclusion</h3><p>Observed union rate is comparable to the average fusion rate previously reported for open and minimally invasive procedure union rates. Mean time to union was observed to be comparable to open procedures union time. Observed overall complication rate is similar to those reported for open techniques as well. Patient reported outcomes demonstrated a significant reduction in postoperative VAS and FFI for the percutaneous metatarsophalangeal arthrodesis with calcaneus bone autograft. Patient satisfaction rates compared favorably to those reported following open surgery.</p><p>Level of evidence.</p><p>Level IV.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iliosacral screw osteosynthesis – state of the art 髂骶螺钉植骨术-最新技术
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05716-5
Alexander Hofmann, Daniel Wagner, Pol Maria Rommens

Iliosacral screw osteosynthesis is a widely recognized technique for stabilizing unstable posterior pelvic ring injuries, offering notable advantages, including enhanced mechanical stability, minimal invasiveness, reduced blood loss, and lower infection rates. However, the procedure presents technical challenges due to the complex anatomy of the sacrum and the proximity of critical neurovascular structures. While conventional fluoroscopy remains the primary method for intraoperative guidance, precise preoperative planning using multiplanar reconstructions and three-dimensional volume rendering is crucial for ensuring accurate placement of iliosacral or transsacral screws. Particular attention must be given to the preoperative evaluation of both the iliosacral and transsacral corridors, as anatomical variations may restrict the available space for screw insertion. This review aims to highlight the essential aspects of sacroiliac osteosynthesis, with a focus on the critical role of thorough preoperative planning and its impact on achieving successful surgical outcomes.

髂骶螺钉固定术是一种被广泛认可的稳定不稳定骨盆后环损伤的技术,具有显著的优点,包括增强机械稳定性、微创、减少失血和降低感染率。然而,由于骶骨复杂的解剖结构和关键神经血管结构的接近,该手术提出了技术挑战。虽然传统的透视术仍然是术中指导的主要方法,但使用多平面重建和三维体积绘制精确的术前规划对于确保准确放置髂骶或经骶螺钉至关重要。必须特别注意髂骶和经骶通道的术前评估,因为解剖变化可能限制螺钉插入的可用空间。这篇综述旨在强调骶髂骨融合术的基本方面,重点是全面的术前计划的关键作用及其对获得成功手术结果的影响。
{"title":"Iliosacral screw osteosynthesis – state of the art","authors":"Alexander Hofmann,&nbsp;Daniel Wagner,&nbsp;Pol Maria Rommens","doi":"10.1007/s00402-024-05716-5","DOIUrl":"10.1007/s00402-024-05716-5","url":null,"abstract":"<div><p>Iliosacral screw osteosynthesis is a widely recognized technique for stabilizing unstable posterior pelvic ring injuries, offering notable advantages, including enhanced mechanical stability, minimal invasiveness, reduced blood loss, and lower infection rates. However, the procedure presents technical challenges due to the complex anatomy of the sacrum and the proximity of critical neurovascular structures. While conventional fluoroscopy remains the primary method for intraoperative guidance, precise preoperative planning using multiplanar reconstructions and three-dimensional volume rendering is crucial for ensuring accurate placement of iliosacral or transsacral screws. Particular attention must be given to the preoperative evaluation of both the iliosacral and transsacral corridors, as anatomical variations may restrict the available space for screw insertion. This review aims to highlight the essential aspects of sacroiliac osteosynthesis, with a focus on the critical role of thorough preoperative planning and its impact on achieving successful surgical outcomes.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of Orthopaedic and Trauma Surgery
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