Pub Date : 2025-11-07DOI: 10.1007/s00402-025-06121-2
Roberta Laggner, Florian Bur, Michael Humenberger, Martin Frossard, Stefan Hajdu, Valerie Weihs
Background
Trochanteric femoral fractures are associated with high morbidity and mortality with a substantial proportion of patients presenting with ongoing antithrombotic therapy (ATT). Evidence regarding the impact of ATT on surgical outcomes and complication rates in this population remains limited. The purpose of this study was to evaluate revision rates, infection risk, surgical timing, and mortality in patients with trochanteric fractures receiving ATT.
Methods
We retrospectively analyzed 656 patients who underwent cephalomedullary nailing for trochanteric femoral fractures between January 2021 and December 2024. Patients were stratified by pre-injury ATT status. The primary outcome was revision surgery; secondary outcomes included infection requiring revision, surgical timing, and mortality at predefined intervals.
Results
Of 656 patients, 319 (48.6%) presented with pre-injury ATT. Revision surgery was required in 33 patients (5.0%) and did not differ significantly between ATT and non-ATT groups (6.0% vs. 4.2%, p = 0.291). Infections occurred in 1.2% of patients, with no excess risk in ATT patients. Patients with pre-injury ATT had significantly higher mortality rates (p = 0.005), although the one-year mortality did not differ significantly (23.8% vs. 23.1%, p = 0.989) between the two groups. Competing risk analyses revealed a significant impact of pre-injury ATT on the mortality (p = 0.004) but not on the revision rates (p = 0.311).
Conclusions
In this large cohort, nearly half of all patients with trochanteric fractures were on ATT at admission. ATT was not associated with increased revision or infection risk. While overall mortality was higher in patients receiving ATT, one-year mortality was comparable between groups, indicating that early excess risk is more likely related to age and comorbidity. These findings suggest that ATT itself does not predispose to adverse surgical outcomes.
背景:股骨粗隆骨折与高发病率和死亡率相关,相当大比例的患者持续接受抗血栓治疗(ATT)。在这一人群中,关于ATT对手术结果和并发症发生率影响的证据仍然有限。本研究的目的是评估接受att治疗的股骨粗隆骨折患者的翻修率、感染风险、手术时机和死亡率。方法回顾性分析2021年1月至2024年12月期间接受股骨粗隆骨折头髓内钉治疗的656例患者。根据损伤前ATT状态对患者进行分层。主要结局是翻修手术;次要结局包括需要翻修的感染、手术时机和预定时间间隔内的死亡率。结果656例患者中,319例(48.6%)出现损伤前ATT, 33例(5.0%)患者需要翻修手术,ATT组与非ATT组之间差异无统计学意义(6.0% vs. 4.2%, p = 0.291)。感染发生在1.2%的患者中,ATT患者没有额外的风险。损伤前ATT患者的死亡率显著高于对照组(p = 0.005),但两组1年死亡率无显著差异(23.8% vs. 23.1%, p = 0.989)。竞争风险分析显示,损伤前ATT对死亡率有显著影响(p = 0.004),但对翻修率没有显著影响(p = 0.311)。结论:在这个大型队列中,近一半的转子骨折患者在入院时接受了ATT治疗。ATT与翻修或感染风险增加无关。虽然接受ATT治疗的患者的总死亡率较高,但两组之间的一年死亡率具有可比性,这表明早期过度风险更可能与年龄和合并症有关。这些发现表明ATT本身并不会导致不良的手术结果。
{"title":"Does ongoing antithrombotic therapy increase the risk of revision after trochanteric fracture fixation? A retrospective cohort study with competing risk analyses","authors":"Roberta Laggner, Florian Bur, Michael Humenberger, Martin Frossard, Stefan Hajdu, Valerie Weihs","doi":"10.1007/s00402-025-06121-2","DOIUrl":"10.1007/s00402-025-06121-2","url":null,"abstract":"<div><h3>Background</h3><p>Trochanteric femoral fractures are associated with high morbidity and mortality with a substantial proportion of patients presenting with ongoing antithrombotic therapy (ATT). Evidence regarding the impact of ATT on surgical outcomes and complication rates in this population remains limited. The purpose of this study was to evaluate revision rates, infection risk, surgical timing, and mortality in patients with trochanteric fractures receiving ATT.</p><h3>Methods</h3><p>We retrospectively analyzed 656 patients who underwent cephalomedullary nailing for trochanteric femoral fractures between January 2021 and December 2024. Patients were stratified by pre-injury ATT status. The primary outcome was revision surgery; secondary outcomes included infection requiring revision, surgical timing, and mortality at predefined intervals.</p><h3>Results</h3><p>Of 656 patients, 319 (48.6%) presented with pre-injury ATT. Revision surgery was required in 33 patients (5.0%) and did not differ significantly between ATT and non-ATT groups (6.0% vs. 4.2%, <i>p</i> = 0.291). Infections occurred in 1.2% of patients, with no excess risk in ATT patients. Patients with pre-injury ATT had significantly higher mortality rates (<i>p</i> = 0.005), although the one-year mortality did not differ significantly (23.8% vs. 23.1%, <i>p</i> = 0.989) between the two groups. Competing risk analyses revealed a significant impact of pre-injury ATT on the mortality (<i>p</i> = 0.004) but not on the revision rates (<i>p</i> = 0.311).</p><h3>Conclusions</h3><p>In this large cohort, nearly half of all patients with trochanteric fractures were on ATT at admission. ATT was not associated with increased revision or infection risk. While overall mortality was higher in patients receiving ATT, one-year mortality was comparable between groups, indicating that early excess risk is more likely related to age and comorbidity. These findings suggest that ATT itself does not predispose to adverse surgical outcomes.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06121-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145456436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1007/s00402-025-06099-x
Rosario Junior Sagliocco, Filippo Leggieri, Andrea Baldini, Domenico Andrea Campanacci, Roberto Civinini, Matteo Innocenti
Introduction
Achieving personalized alignment in total knee arthroplasty (TKA) with conventional instrumentation remains challenging. This study validates a novel trigonometric formula that calculates the exact lateralization needed for the tibial extramedullary guide based on preoperative weight-bearing X-rays.
Methods
We retrospectively analysed 196 patients who underwent TKA between November 2018 and June 2023. Inclusion criteria: patients with preoperative weight-bearing AP lower limb X-rays aged 18 or older. Exclusion criteria: previous total hip arthroplasty, those without consent. The formula LAT = LENG(S) × sin α angle calculated tibial guide lateralization, where LAT was the lateralization distance, LENG(S) was the tibial length from radiographs, and α angle was the tibial coronal correction angle. The true radiographic lateralization was measured to validate the formula’s accuracy and defined a “safety zone” representing acceptable surgical margins to validate the formula’s accuracy and defined a “safety zone” representing acceptable surgical margins. The Intraclass Correlation Coefficient (ICC) was used to test for the measurement consistency among observers. 95% Clopper-Pearson Confidence Interval was calculated for the frequency of lateralization falling within a “safety zone”. A T-test compared LAT measurements with true radiographic lateralization.
Results
ICC showed that 97.2% of lateralization measurements fell within the defined “safety cone” (95% CI 93.9–98.9%). Inter-observer reliability was high (ICC 0.91). No differences were found between the formula-derived measurements and the true radiographic lateralization. The 95% Clopper-Pearson Confidence Interval was 93.9–98.9%. LAT was found to fall outside the safety cone with a total mean of 2.3° (range 1–5) in 2.8% of the cases, with a mean error in the degree of proximal tibial cut of -0.67° (range − 1 - +1). No association between CPAK and cases within or outside the safety cone was found (χ²= 5.014, p = 0.658).
Conclusions
This validated trigonometric formula enables surgeons to accurately calculate tibial guide lateralization for personalized alignment using only conventional instrumentation and standard radiographs. The method’s 97.2% accuracy within safe surgical margins supports its use as a reliable preoperative planning tool for personalized TKA alignment without requiring specialized software or robotic assistance.
在全膝关节置换术(TKA)中使用传统器械实现个性化对齐仍然具有挑战性。本研究验证了一种新的三角公式,该公式基于术前负重x射线计算胫骨髓外导尿管所需的精确侧化。方法回顾性分析2018年11月至2023年6月期间接受TKA的196例患者。纳入标准:术前负重AP下肢x线片患者年龄≥18岁。排除标准:既往全髋关节置换术,未经同意者。公式LAT = LENG(S) × sin α角计算胫骨引导侧化,其中LAT为侧化距离,LENG(S)为胫骨x线片长度,α角为胫骨冠状矫正角。测量真实的x线侧化以验证公式的准确性,并定义一个代表可接受手术边缘的“安全区”来验证公式的准确性,并定义一个代表可接受手术边缘的“安全区”。用类内相关系数(Intraclass Correlation Coefficient, ICC)检验观察者间测量的一致性。对于侧化频率落在“安全区”内的情况,计算95%的Clopper-Pearson置信区间。t检验比较了LAT测量值和真实的x线侧位。结果icc显示97.2%的侧化测量值落在定义的“安全锥”内(95% CI 93.9-98.9%)。观察者间信度高(ICC 0.91)。公式导出的测量结果与真实的x线侧位之间没有差异。95%的Clopper-Pearson置信区间为93.9-98.9%。在2.8%的病例中发现LAT落在安全锥外,总平均为2.3°(范围1 - 5),胫骨近端切割程度的平均误差为-0.67°(范围- 1 - +1)。CPAK与安全锥内、外病例无相关性(χ 2 = 5.014, p = 0.658)。结论:经过验证的三角公式使外科医生能够仅使用常规器械和标准x线片准确计算胫骨导板侧位以进行个性化对齐。该方法在安全手术范围内的97.2%的准确率支持其作为可靠的术前规划工具用于个性化TKA对齐,而无需专门的软件或机器人辅助。
{"title":"Extramedullary tibial guide orientation in TKA personalized alignment: validation of a trigonometric method","authors":"Rosario Junior Sagliocco, Filippo Leggieri, Andrea Baldini, Domenico Andrea Campanacci, Roberto Civinini, Matteo Innocenti","doi":"10.1007/s00402-025-06099-x","DOIUrl":"10.1007/s00402-025-06099-x","url":null,"abstract":"<div><h3>Introduction</h3><p> Achieving personalized alignment in total knee arthroplasty (TKA) with conventional instrumentation remains challenging. This study validates a novel trigonometric formula that calculates the exact lateralization needed for the tibial extramedullary guide based on preoperative weight-bearing X-rays.</p><h3>Methods</h3><p>We retrospectively analysed 196 patients who underwent TKA between November 2018 and June 2023. Inclusion criteria: patients with preoperative weight-bearing AP lower limb X-rays aged 18 or older. Exclusion criteria: previous total hip arthroplasty, those without consent. The formula LAT = LENG(S) × sin α angle calculated tibial guide lateralization, where LAT was the lateralization distance, LENG(S) was the tibial length from radiographs, and α angle was the tibial coronal correction angle. The true radiographic lateralization was measured to validate the formula’s accuracy and defined a “safety zone” representing acceptable surgical margins to validate the formula’s accuracy and defined a “safety zone” representing acceptable surgical margins. The Intraclass Correlation Coefficient (ICC) was used to test for the measurement consistency among observers. 95% Clopper-Pearson Confidence Interval was calculated for the frequency of lateralization falling within a “safety zone”. A T-test compared LAT measurements with true radiographic lateralization.</p><h3>Results</h3><p>ICC showed that 97.2% of lateralization measurements fell within the defined “safety cone” (95% CI 93.9–98.9%). Inter-observer reliability was high (ICC 0.91). No differences were found between the formula-derived measurements and the true radiographic lateralization. The 95% Clopper-Pearson Confidence Interval was 93.9–98.9%. LAT was found to fall outside the safety cone with a total mean of 2.3° (range 1–5) in 2.8% of the cases, with a mean error in the degree of proximal tibial cut of -0.67° (range − 1 - +1). No association between CPAK and cases within or outside the safety cone was found (χ²= 5.014, <i>p</i> = 0.658).</p><h3>Conclusions</h3><p>This validated trigonometric formula enables surgeons to accurately calculate tibial guide lateralization for personalized alignment using only conventional instrumentation and standard radiographs. The method’s 97.2% accuracy within safe surgical margins supports its use as a reliable preoperative planning tool for personalized TKA alignment without requiring specialized software or robotic assistance. </p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06099-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Introduction</h3><p>Metacarpal shaft fractures require techniques that balance stability with rapid rehabilitation. Conventional crossed K‑wires are minimally invasive yet provide limited interfragmentary compression and may compromise reduction, whereas mini‑plates offer rigid fixation at the expense of larger incisions, longer operative time, and higher cost. Building on these trade‑offs, we evaluated a transverse K‑wire technique across adjacent metacarpals augmented with the Nice knot. In our cohort, this approach delivered perioperative efficiencies—no secondary surgery, shorter operative time, smaller incisions, and lower hospitalization costs—without increasing complications. Early joint mobility at 4 weeks was statistically greater with the Nice knot approach, but the effect size was small and likely of limited clinical relevance.</p><h3>Materials and methods</h3><p>We performed a retrospective cohort analysis of patients treated for second to fifth metacarpal shaft fractures at our institution between December 2021 and January 2025. Two groups were compared: (1) Transverse K‑wire fixation across adjacent metacarpals combined with Nice knot suture augmentation (Nice knot group) and (2) conventional open reduction and internal fixation with mini‑plates (plate group).Outcome measures included average hospitalization cost, operative time, incision length, postoperative metacarpophalangeal joint range of motion (ROM) at 2,4 and 6 weeks, grip strength recovery, time to union, Disabilities of the Arm, Shoulder and Hand (DASH) score, and complication rate. Baseline variables (age, sex, dominant‑hand involvement, preoperative waiting period) were assessed for group comparability.</p><h3>Results</h3><p>Baseline characteristics—including patient age, sex, dominance of the injured hand, and time from injury to surgery—did not differ significantly between the Nice knot and plate groups (all <i>P</i> > 0.05). Relative to the plate group, the Nice knot group had a 29.3% lower mean hospitalization cost (432.7 ± 43.7 EUR vs. 611.5 ± 94.5 EUR; <i>P</i> < 0.01) and a 38.8% shorter mean operative time (23.2 min vs. 37.9 min; <i>P</i> < 0.01), accompanied by a smaller median incision length (2.5 cm vs. 4.7 cm; <i>P</i> < 0.01). At 4 weeks postoperatively, the median metacarpophalangeal joint range of motion was greater in the Nice knot cohort (82°vs 80°; <i>P</i> = 0.039). By 6 weeks, there were no significant between‑group differences in joint mobility, grip strength recovery, or time to fracture union (all <i>P</i> > 0.05). At the primary 6‑month endpoint, DASH scores did not differ significantly between groups (<i>P</i> > 0.05). Complication rates were similarly low (3.03% vs. 3.33%; <i>P</i> = 1.000), indicating that trans‑metacarpal K‑wire fixation with Nice knots does not increase the risk of adverse events relative to plate fixation.At 6 months, DASH difference was 1.0 (95% CI − 0.8 to 2.8), meeting non‑inferiority versus Δ
掌骨干骨折需要平衡稳定性和快速康复的技术。传统的交叉K针是微创的,但提供有限的碎片间压缩,可能会影响复位,而微型钢板提供刚性固定,但以更大的切口、更长的手术时间和更高的成本为代价。在这些权衡的基础上,我们评估了一种横向K线技术,该技术在相邻的掌骨上加尼斯结。在我们的队列中,这种方法提供了围手术期的效率——没有二次手术,更短的手术时间,更小的切口,更低的住院费用——没有增加并发症。尼斯结入路4周早期关节活动度在统计学上更大,但效应量很小,可能有限的临床相关性。材料和方法我们对2021年12月至2025年1月期间在我院接受第二至第五次掌骨干骨折治疗的患者进行了回顾性队列分析。两组比较:(1)相邻掌骨横向K线内固定联合尼斯结缝合增强术(尼斯结组)和(2)常规切开复位微型钢板内固定(钢板组)。结果指标包括平均住院费用、手术时间、切口长度、术后2周、4周和6周掌指关节活动范围(ROM)、握力恢复、愈合时间、臂、肩和手残疾(DASH)评分和并发症发生率。基线变量(年龄、性别、主手受累、术前等待时间)被评估为组间可比性。结果基线特征,包括患者的年龄、性别、受伤手的优势以及从受伤到手术的时间,在尼斯结组和钢板组之间没有显著差异(均P >; 0.05)。与钢板组相比,尼斯结组平均住院费用降低29.3%(432.7±43.7欧元比611.5±94.5欧元;P < 0.01),平均手术时间缩短38.8%(23.2分钟比37.9分钟;P < 0.01),切口正中长度更小(2.5 cm比4.7 cm; P < 0.01)。术后4周,尼斯结组的中位掌指关节活动范围更大(82°vs 80°;P = 0.039)。6周时,两组在关节活动度、握力恢复或骨折愈合时间方面无显著差异(均P >; 0.05)。在主要6个月终点,两组间DASH评分无显著差异(P > 0.05)。并发症发生率同样较低(3.03% vs. 3.33%; P = 1.000),表明尼斯节经掌骨K针固定相对于钢板固定不会增加不良事件的风险。6个月时,DASH差异为1.0 (95% CI - 0.8 - 2.8),与Δ = 10相比符合非劣效性。结论相邻掌骨横向K线内固定联合尼斯结缝合增强与钢板内固定相比,6个月的功能效果相当,同时减少了成本、手术时间和切口长度,且未增加并发症的风险。在4周(≈2°)时观察到MCP AROM具有统计学上显着的小优势,但其临床相关性可能有限。这些研究结果支持该技术是一种安全、微创、经济的选择,用于移位的斜或螺旋型掌骨骨折。
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Pub Date : 2025-10-30DOI: 10.1007/s00402-025-06092-4
Amy Pearce, Chaitanya Joshi, Georgina Chan, Tony Lamberton, Simon MacLean, Andrew Vane, Kim Hébert-Losier
Introduction
Compare 10-year survival of the cemented highly crosslinked polyethylene Exeter® Rimfit™ (Rimfit) Cup and its predecessor, the ultra-high molecular weight polyethylene Exeter® Contemporary Flanged Cup™ (ECF), both with an Exeter® V40™ stem, in primary total hip arthroplasty (THA) for osteoarthritis in the Bay of Plenty region of NZ.
Method
We extracted national registry data for THA surgeries in the region between 1 January 2003 and 30 June 2023 and report the 10-year survival and reasons for revision of the two fully cemented implants (n = 495). We compared standard Kaplan-Meier estimates using the log-rank test. Cox proportional hazard models investigated the potential influence of six patient variables on the survival of each implant: sex, age, body mass index (BMI), ethnicity, American Society of Anesthesiologists (ASA) rating, and funding source (public/private).
Results
No statistically significant difference in 10-year survival rate between the implants (p = 0.334) (ECF 95.6% [93.4, 97.9], Rimfit 97.0% [95.9, 98.2]) or statistically significant difference in revision reasons between the implants (p = 0.09) was noted. Cox regression revealed no statistically significant influence of any of the six patient variables on the 10-year survival of the ECF (p = 0.584) or Rimfit (p = 0.611).
Conclusion
Both implants exceeded 95% survival at 10-years, which is favourable compared to the corresponding 94.8% national survivorship of cemented implants in NZ. There is no statistically significant difference in the 10-year survival rate or reasons for revision of the two cemented implants compared in this region. The Rimfit appears a suitable alternative to the ECF, from a survival and revision perspective.
{"title":"10-year survival comparison of two cemented implants in primary total hip arthroplasty for osteoarthritis: a New Zealand regional study","authors":"Amy Pearce, Chaitanya Joshi, Georgina Chan, Tony Lamberton, Simon MacLean, Andrew Vane, Kim Hébert-Losier","doi":"10.1007/s00402-025-06092-4","DOIUrl":"10.1007/s00402-025-06092-4","url":null,"abstract":"<div><h3>Introduction</h3><p>Compare 10-year survival of the cemented highly crosslinked polyethylene Exeter<sup>®</sup> Rimfit™ (Rimfit) Cup and its predecessor, the ultra-high molecular weight polyethylene Exeter<sup>®</sup> Contemporary Flanged Cup™ (ECF), both with an Exeter<sup>®</sup> V40™ stem, in primary total hip arthroplasty (THA) for osteoarthritis in the Bay of Plenty region of NZ.</p><h3>Method</h3><p>We extracted national registry data for THA surgeries in the region between 1 January 2003 and 30 June 2023 and report the 10-year survival and reasons for revision of the two fully cemented implants (<i>n</i> = 495). We compared standard Kaplan-Meier estimates using the log-rank test. Cox proportional hazard models investigated the potential influence of six patient variables on the survival of each implant: sex, age, body mass index (BMI), ethnicity, American Society of Anesthesiologists (ASA) rating, and funding source (public/private).</p><h3>Results</h3><p>No statistically significant difference in 10-year survival rate between the implants (<i>p</i> = 0.334) (ECF 95.6% [93.4, 97.9], Rimfit 97.0% [95.9, 98.2]) or statistically significant difference in revision reasons between the implants (<i>p</i> = 0.09) was noted. Cox regression revealed no statistically significant influence of any of the six patient variables on the 10-year survival of the ECF (<i>p</i> = 0.584) or Rimfit (<i>p</i> = 0.611).</p><h3>Conclusion</h3><p>Both implants exceeded 95% survival at 10-years, which is favourable compared to the corresponding 94.8% national survivorship of cemented implants in NZ. There is no statistically significant difference in the 10-year survival rate or reasons for revision of the two cemented implants compared in this region. The Rimfit appears a suitable alternative to the ECF, from a survival and revision perspective.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06092-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}