Archives of Orthopaedic and Trauma Surgery最新文献

Purpose

The two-stage exchange revision represents a pivotal strategy in the management of prosthetic joint infections, wherein the judicious timing of reimplantation serves as a crucial determinant for therapeutic success. At present, attempts have been made to utilize predictive models to establish the optimal timing for reimplantation; however, their predictive accuracy remains unsatisfactory. This inadequacy primarily arises from the lack of dependable predictive indicators, which demonstrate inconsistent effectiveness across various studies and occasionally yield contradictory outcomes. Therefore, identifying solid predictive indicators is in desperate need.

Methods

Studies reporting outcomes of the two-stage exchange revision till June, 2023 were systematically retrieved, screened and subject to quality analysis. Basic characteristics of these studies were firstly summarized. Subsequently, factors of interest regarding clinical information, blood and body fluid test results, pathogen test results of the recurrent and recurrent-free cohorts were extracted and submitted to a fixed or random effects model. Meanwhile, evaluation of publication bias and sensitivity was performed.

Results

After filtering, a total of 45 studies were finally involved. Pooled analysis suggested that the recurrent cohort exhibited elevated incidences of body mass index (BMI) > 30, smoking and alcohol habits, diabetes, sinus tract, positive culture, and G⁻, polymicrobial and drug-resistant infections. Additionally, higher levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial white blood cell (WBC) count, and polymorphonuclear percentage (PMN%) were observed in the recurrent cohort. On the other hand, the results of D-dimer and fibrinogen were ambiguous, and no difference regarding peripheral WBC count was observed. Forest plots suggested a low risk of publication bias. Besides, sensitivity analysis indicated good stability of the aforementioned indicators, except D-dimer and fibrinogen.

Conclusion

To sum up, BMI > 30, smoking and alcohol habits, diabetes, sinus tract, positive culture, and G-, polymicrobial and drug-resistant infections, CRP, ESR, synovial WBC and PMN% exhibited significant differences between recurrent and recurrent-free cohorts. Therefore, these indicators may be considered as potential predictive factors for the further development of a prognostic model that aids the determination of reimplantation timing. Nevertheless, the efficacy of these indicators remains to be further confirmed.

Registration number

Prospero ID: CRD42022296568.

Introduction

Low rates of venous thromboembolism (VTE) have been found in patients with isolated orthopaedic trauma below the knee. Many surgeons routinely provide chemical thromboprophylaxis in these injuries, however. This is not without inherent risks, and this remains a controversial topic in perioperative care in orthopaedic trauma. This systematic review and meta-analysis was performed to look at rates of VTE in patients with isolated orthopaedic fractures below the knee, grouped by whether they received chemical prophylaxis versus no chemical prophylaxis.

Methods

A systematic review was performed comparing VTE with and without chemical thromboprophylaxis following isolated orthopaedic fracture below the knee. A chi-square analysis was then performed on data including patients who received chemical prophylaxis versus those who did not from all 25 included articles. The articles were grouped according to type of study, such as observational versus randomized controlled trial (RCT), and then further subdivided according to surgical intervention status, and whether routine screening for thromboembolism was utilized to diagnose. Risk of bias assessment was performed using the ROBINS-I criteria for cohort studies and the Cochrane RoB 2 tool for randomized controlled trials. A random effects pooled logistic regression and Fisher’s exact tests were then performed.

Results

222,188 patients were found from 25 articles. Chemical prophylaxis was given to 8,666 patients, and VTE was reported in 347 cases (4.0%). 213,522 patients did not receive chemical prophylaxis, and VTE was reported in 2,185 (1.02%) (χ² (1, n = 222,188) = 656.8, p < .00001). Pooled logistic regression revealed that patients receiving prophylaxis were 0.5 times less likely to develop VTE. With a calculated population baseline risk of 1.5% for developing VTE, the number needed to treat (NNT) with chemical prophylaxis is 134 to prevent 1 VTE after fracture below the knee.

Conclusions

In patients with isolated orthopaedic trauma below the knee, indiscriminate use of chemical VTE prophylaxis is not recommended due to the lack of significant benefit and high NNT.

Level of Evidence

Level III.

Aim

The aim of this study was to investigate on fulfillment of expectations and patient satisfaction after surgical treatment of complex proximal tibial fractures.

Methods

In this prospective study 114 patients who suffered a complex tibial fracture (AO/OTA-Type B and C) were enrolled. At follow-up, based on the Hospital For Special Surgery-Knee Surgery Expectations Survey (HFSS-KSES), an individualized questionnaire was used to evaluate whether the preoperative formulated expectations had been fulfilled. In addition, condition of the knee joint (rated 0–4), overall satisfaction (rated 0–4) with the outcome, the Knee injury and Osteoarthritis Outcome Score (KOOS), and SF-12 was used.

Results

Fulfillment of expectations for abilty to run, to knee, and regain an intact status of the knee joint performed worst in the HFSS-KSE. Highest fulfillment was reached for psychological well-being and to interact socially. No statistical difference was found between the two fracture groups (AO/OTA-Type B vs. C). In the study cohort n = 81 patients (83.5%) were satisfied or very satisfied with the outcome. Mean satisfaction in the study cohort was 3.5. Satisfaction correlated highly significant with all items of the HFSS-KSE survey. Results vary in the different fracture groups. Satisfaction also correlates highly significant with the condition of the knee joint as well as with all dimensions of the KOOS score and the PCS of the SF-12 survey.

Conclusion

In patients who suffered a complex proximal tibial fracture, fulfillment of preoperative expectations is only limited. Nevertheless, overall satisfaction with the outcome is high, and correlates to a high degree with fulfillment of joint functionality and current health status. The fracture type does not influence these results.

Introduction

A sinus tract, an abnormal channel between the skin and joint, is a major criterion that proves the presence of an underlying periprosthetic joint infection. Its presence not only increases failure rates but also leads to poor outcomes. Despite its clinical relevance, little is known about risk factors and underlying microorganism profiles. The aim of this study was to investigate PJIs of the hip with a sinus tract, identifying risk factors and microorganism profiles.

Materials and methods

This was a retrospective case control study of all PJI cases of the hip treated at our institution. A total of 4,368 cases with a PJI of the hip were identified of which 653 patients (14.95%), displayed a sinus tract. Univariate and multivariate analysis was performed. Odds ratio (OR) and 95% confidence interval (CI) were presented.

Results

Multivariate analysis identified diabetes mellitus (p = 0.004; OR = 1.62; 95% CI 1.17–2.44), history of ileus (p < 0.001; OR = 4.65; 95% CI 2.38–9.08), osteomyelitis (p < 0.001; OR = 2.35; 95% CI 1.65–3.35) and prior revisions (p = 0–014; OR = 1.36; 95% CI 1.07–1.74) as risk factors for a sinus tract. Polymicrobial infections (p < 0.001; OR = 2.35; 95% CI 1.86–2.96), Staphylococcus aureus (p < 0.001; OR = 3.67; 95% CI 2.86–4.71) and Escherichia coli (p = 0.014; OR = 1.65; 95% CI 1.11–2.46) were associated with a sinus tract in PJIs of the hip.

Conclusions

Microorganism profiles and risk factors differ significantly in patients with PJI of a THA with a sinus tract. These insights can help surgeons in planning and selecting appropriate antibiotics for cement loading and empiric antibiotic treatment, as well as in risk stratification of patients, who may develop a sinus tract following THA.

Core decompression was developed as a joint-preserving procedure for patients with early-stage osteonecrosis of the femoral head. Previous studies indicated a high success rate that outperforms nonoperative management of pre-collapse hips. The traditional single-tunnel core decompression technique uses a cannulated drill bit inserted into the lateral cortex of the proximal femur. Multiple small drilling was introduced to decrease the risk of fracture through a less invasive technique. Adjunctive therapeutics such as tantalum rods, bone-grafting, orthobiologic (e,g, bone marrow aspirate concentrate, mesenchymal stem cells, platelet-rich plasma, and human umbilical cord mesenchymal stem cell extracts) as well as electric stimulation have all been studied. No consensus regarding the ideal treatment has been reached. This review analyzes the advantages and disadvantages of current core decompression techniques to provide orthopaedic surgeons with direction in managing patients with avascular necrosis of the femoral head.

Introduction

Perioperative steroids administration in total joint arthroplasty gained popularity for pain relief, reduction of postoperative nausea and vomiting (PONV) and enhanced recovery. The purpose of this study is to systematically review and meta-analyze comparative results of prospective randomized trials focused on the effect of systemic steroid administration at different dosages in THA for hip osteoarthritis. The hypothesis is that perioperative systemic steroid administration has a positive impact on postoperative outcomes.

Material and methods

A systematic review of the literature has been performed, following the Cochrane Handbook of Systematic Reviews of Interventions and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for study selection. A comprehensive search was performed across multiple databases (Cochrane Central Register of Controlled Trials, MEDLINE/PubMed, Embase, Scopus, the Science Citation Index Expanded from Web of Science, ScienceDirect, CINAHL and LILACS) covering the period from 1990 to 2023. Placebo-controlled, prospective randomized trials that reported comparative outcomes of total hip arthroplasty (THA) with the use of systemic corticosteroids during the perioperative period were considered eligible for inclusion.

Results

A total of 8 prospective randomized trials involving 675 patients who underwent elective THA (369 in the study group and 306 in the control group) were finally included in this systematic review. Perioperative systemic steroid administration in THA provides a significant benefit in terms of length of stay (LOS), pain, opioid consumption, postoperative nausea and vomiting (PONV) and inflammatory response without improving post-operative complications. The high-dose steroid administration (≥ 20 mg of steroid equivalent) provided only a reduction of the inflammatory response of measured biomarkers at 24 and 48 h.

Conclusions

The use of steroids in total hip arthroplasty (THA) has positive effects in terms of reducing length of stay (LOS), post operative pain, opioid use, postoperative nausea and vomiting (PONV) and systemic inflammatory response.

Fragility and insufficiency fractures of the pelvis (FFP) and sacrum (SIF) are increasingly prevalent, particularly among the elderly, due to weakened bone structure and low-energy trauma. Chronic instability from these fractures causes persistent pain, limited mobility, and significant reductions in quality of life. Hospitalization is often required, with substantial risks of loss of independence (64–89%) and high mortality rates (13–27%). While conservative treatment is possible, surgical intervention is preferred for unstable or progressive fractures. FFP and SIF are primarily associated with osteoporosis, with 71% of patients not receiving adequate secondary fracture prevention. Imaging modalities play a crucial role in diagnosis. Conventional radiography often misses sacral fractures, while computed tomography (CT) is the gold standard for evaluating fracture morphology. Magnetic resonance imaging (MRI) offers the highest sensitivity (99%), essential for detecting complex fractures and assessing bone edema. Advanced techniques like dual-energy CT and SPECT/CT provide further diagnostic value. Rommens and Hofmann’s classification system categorizes FFP based on anterior and posterior pelvic ring involvement, guiding treatment strategies. Progression from stable fractures (FFP I–II) to highly unstable patterns (FFP IV) is common and influenced by factors like pelvic morphology, bone density, and sarcopenia. Treatment varies based on fracture type and stability. Non-displaced posterior fractures can be managed with sacroplasty or screw fixation, while displaced or unstable patterns often require more invasive methods, such as triangular lumbopelvic fixation or transsacral bar osteosynthesis. Sacroplasty provides significant pain relief but has limited stabilizing capacity, while screw augmentation with polymethylmethacrylate improves fixation in osteoporotic bones. Anterior ring fractures may be treated with retrograde transpubic screws or symphyseal plating, with biomechanical stability and long-term outcomes depending on fixation techniques. FFP and SIF management requires a multidisciplinary approach to ensure stability, pain relief, and functional recovery, emphasizing early diagnosis, tailored surgical strategies, and secondary prevention of osteoporoticfractures.

Introduction

There is conflicting data in the literature regarding the clinical utility of wearable devices. This study examined the association between patient reported outcome measures (PROMs) and step and stair flight counts obtained from wearable devices in postoperative total hip arthroplasty (THA) patients.

Methods

Data was collected from a multicenter prospective longitudinal cohort study from October 2018 to February 2022. A smartphone-based platform with smartwatch was utilized for collection of daily step and stair flight counts. Subjects (N = 1644) completed the Hip disability and Osteoarthritis Outcome Score for Joint Replacement (HOOS JR) and numerical rating scale (NRS) pain scores preoperatively and at 1 and 3 months postoperatively. Patients who reported living in a multi-level home (N = 931) were included in analysis of stair flight counts. Pearson correlation coefficients were calculated to determine correlations between step and stair flight counts with NRS pain and HOOS JR scores.

Results

Step counts demonstrated a weak negative correlation to NRS pain scores at preoperative (r = − 0.15, p < 0.0001), 1-month (r = − 0.15, p < 0.0001), and 3-months follow-up (r = − 0.06, p = 0.05). Step counts demonstrated a weak positive correlation with HOOS JR scores at preoperative (r = 0.16, p < 0.0001), 1-month (r = 0.15, p < 0.0001), and 3-months (r = 0.13, p < 0.0001). Stair flight counts demonstrated a weak negative correlation with NRS pain preoperatively (r = − 0.19, p < 0.0001) and at 1-month (r = − 0.11, p = 0.003). Stair flight counts positively correlated with HOOS JR scores at preoperative (r = 0.24, p < 0.0001), 1-month (r = 0.15, p < 0.0001), and 3-months (r = 0.09, p = 0.02).

Conclusion

The utilization of wearable technology can enhance the evaluation of patient outcomes after THA, primarily due to the observed correlation between data collected from wearables and PROMs. Our study highlights the importance of the use of objective data, in addition to subjective patient reported data, when analyzing postoperative patient progress, which propels forward the field of postoperative THA patient care.

Objective

To measure the predictive value of three perioperative risk assessment tools (National Surgical Quality Improvement Program–NSQIP, Modified 5-factor Frailty Index–mFI-5, and Score for Trauma Triage in Geriatric and Middle Aged–STTGMA) in predicting postoperative complications in older adult ankle fractures.

Materials and methods

This is a retrospective study of surgically treated isolated older adult ankle fractures at an academic center between 2007 and 2022. Exclusion criteria included age < 55 years, presence of pathologic fractures, and having multiple orthopaedic injuries. Patient sociodemographic information, injury characteristics, clinical outcomes, and complications were obtained. Data was entered into the NSQIP, mFI-5, and STTGMA calculators. Descriptive statistics and univariable logistic regression models were calculated for each outcome of interest. Area under the receiver operative curves (AUC) were determined as a measure of tool discrimination.

Results

382 patients met inclusion criteria. The average age was 67 years, 33% were male, and 87% ambulated without assistive devices prior to injury. 23.6% of all patients had a complication: 12.8% had at least one minor complication, 15.7% had at least one major complication, and 2.4% had surgical complications. Mortality within 1 year of initial injury was 2.9%. NSQIP was the best predictor of any complication (AUC 0.74) compared to the mFI-5 (AUC 0.68), and STTGMA (AUC 0.72).

Conclusions

NSQIP performed better than mFI-5, STTGMA, and CCI for postoperative complications and mortality, but none of the perioperative risk assessment tools performed exceptionally well in the context of isolated older adult ankle fractures.

Introduction

Total lower limb arthroplasties are standard orthopedic surgeries that are steadily increasing in modern civilization. In proportion, the number of revision arthroplasties and the corresponding financial burden for healthcare systems will increase. The present clinical investigation analyzed morbidities after aseptic revision knee arthroplasty.

Methods

Data from 122 patients following aseptic revision TKA (total knee arthroplasty) were collected. The study collected information on systemic and surgical complications during hospitalization and follow-up, blood transfusion units, and changes in Hb and CRP levels. Hb and CRP were measured preoperatively and on postoperative days 1, 2, and 4. Statistical analyses were performed using IBM SPSS version 29.

Results

Significant differences were observed in systemic, surgery-related and blood transfusion rates and reasons for knee replacement changes based on age and gender. Of the patients, 38.5% received a full component change, 11.5% received a partial component replacement (either femoral or tibial), 30.3% had an isolated inlay change, and 19.7% underwent debridement only. Femoral and tibial loosening were more frequent in patients over 75 years and those with longer intervals between the initial operation and re-presentation (p = 0.001). Patients with movement deficits and malposition presented earlier for consultation (p = 0.02). Prolonged high CRP levels were significantly correlated with systemic complications, longer hospital stays, and extended operative times.

Conclusions

Aseptic knee revision arthroplasty is a complex procedure with perioperative morbidities that can significantly impact outcomes. Age and gender are crucial factors in managing complications during hospitalization and follow-up. Elderly patients, particularly those over 75 years, are more prone to aseptic loosening and require tailored preoperative preparation. The study underscores the importance of individualized patient care strategies to mitigate risks and improve outcomes in aseptic knee revision arthroplasty.

Trial registration: Not applicable.