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Pelvic insufficiency fractures after radiation therapy for pelvic cancer in female patients: an updated meta-analysis of 11,272 patients. 盆腔癌放疗后女性患者盆腔功能不全骨折:11,272例患者的最新荟萃分析
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-24 DOI: 10.1007/s00402-026-06269-5
Mingchen Gao, Zihan Qiu, Zhijian Xu, Chengliang Zhao, Feng Zhong, Tianlin Gao
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引用次数: 0
The ulna osteotomy locking plate II in patients with ulnocarpal impaction syndrome: a retrospective evaluation. 尺骨截骨锁定钢板II在尺腕嵌塞综合征患者中的应用:回顾性评价。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-17 DOI: 10.1007/s00402-026-06223-5
Stefan Benedikt, Ulrike Seeher, Moritz Stricker, Simone Bode, Kerstin Stock, Rohit Arora
{"title":"The ulna osteotomy locking plate II in patients with ulnocarpal impaction syndrome: a retrospective evaluation.","authors":"Stefan Benedikt, Ulrike Seeher, Moritz Stricker, Simone Bode, Kerstin Stock, Rohit Arora","doi":"10.1007/s00402-026-06223-5","DOIUrl":"10.1007/s00402-026-06223-5","url":null,"abstract":"","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tranexamic acid reduces transfusion requirements after pelvic osteotomy: a nationwide propensity score-matched analysis. 氨甲环酸减少骨盆截骨术后输血需求:一项全国性倾向评分匹配分析。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-16 DOI: 10.1007/s00402-026-06272-w
Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kazuyoshi Baba, Hiroaki Kurishima, Ryuichi Kanabuchi, Hiroki Kawamata, Hideki Fukuchi, Kiyohide Fushimi, Kenj Fujimori, Toshimi Aizawa
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引用次数: 0
Revision rate of large head diameter metal-on-metal total hip arthroplasty: long-term results 大直径金属对金属全髋关节置换术的翻修率:远期效果
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-14 DOI: 10.1007/s00402-026-06258-8
Hiroki Wakabayashi, Shine Tone, Yohei Naito, Akihiro Sudo, Masahiro Hasegawa

Background

To assess the long-term outcomes (minimum 10 years) of total hip arthroplasty (THA) using a large head diameter metal-on-metal (MoM) acetabular prosthesis.

Methods

In total, 108 primary THAs (98 patients) were performed using a Cormet MoM acetabular prosthesis. Clinical hip function, radiographic evaluation and revision rate were evaluated.

Results

Of the 98 patients, 15 (16 hips) followed up for < 10 years were excluded. Among the remaining 92 hips (83 patients), 35 (38.0%) had pseudotumors (PTs) detected by MRI at an average of 5.0 years after the initial THA. On radiographic evaluation, osteolysis (OL) was noted in 10 hips (10.8%) on the cup side and six hips (6.5%) on the stem side. Loosening was observed in six hips (6.5%) on the cup side, whereas no loosening was noted on the stem side. Twenty-three hips (22 patients) were switched to metal-on-polyethylene articulation between 1.2 and 14.7 years (mean: 6.3 years) postoperatively due to pain, swelling, infection, and/or implant failure. In this analysis, cup failure (OL, loosening, or both) was the highest in patients with revision surgery compared to those with PTs but not revision surgery and those without PTs.

Conclusions

The prevalence of PTs was 38.0%, and that of revision surgery was 25%. Some cases required revisions even after 10 years following surgery. We advise against its continued use and recommend regular clinical surveillance, such as MRI, to detect adverse reactions to metal debris and periprosthetic joint infection early.

背景:评估使用大直径金属对金属(MoM)髋臼假体的全髋关节置换术(THA)的长期疗效(至少10年)。方法采用Cormet MoM髋臼假体行108例原发性髋关节置换术(98例)。评估临床髋关节功能、影像学评价及翻修率。结果98例患者中,15例(16髋)随访10年。在其余92髋(83例患者)中,35例(38.0%)在首次THA术后平均5.0年MRI检测到假肿瘤(PTs)。x线评估显示,杯侧10髋(10.8%)和柄侧6髋(6.5%)出现骨溶解(OL)。在杯侧观察到6个髋关节(6.5%)松动,而在柄侧没有发现松动。由于疼痛、肿胀、感染和/或植入物失败,23髋(22例患者)在术后1.2至14.7年(平均6.3年)间切换到金属-聚乙烯关节。在本分析中,与未行翻修手术的患者和未行翻修手术的患者相比,行翻修手术的患者杯型衰竭(OL、松动或两者兼而有之)发生率最高。结论PTs发生率为38.0%,翻修手术发生率为25%。有些病例甚至在手术后10年还需要复查。我们建议不要继续使用,并建议定期进行临床监测,如MRI,以及早发现金属碎片和假体周围关节感染的不良反应。
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引用次数: 0
Favorable midterm clinical results of medial unicompartmental knee arthroplasty guided by coronal limb alignment using an image-free navigation system 采用无图像导航系统冠状肢体对齐引导的内侧单室膝关节置换术中期临床效果良好
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-13 DOI: 10.1007/s00402-026-06264-w
Kengo Shimozaki, Shingo Shimozaki, Eiji Shimozaki

Introduction

Medial unicompartmental knee arthroplasty results in good postoperative motion and high patient satisfaction. However, inaccurate bone resection during manual procedures can cause tibial fractures, implant subsidence, or lateral compartment osteoarthritis. To improve accuracy, we performed medial unicompartmental knee arthroplasty using an image-free navigation system, with a target postoperative alignment of 2°–5° varus. This study evaluated midterm clinical outcomes and safety.

Materials and methods

This single-center retrospective case series included 144 consecutive knees (25 in men and 119 in women; mean age, 72.2 years) that underwent medial unicompartmental knee arthroplasty for varus osteoarthritis between 2011 and 2021, with at least three years of follow-up (mean, 63.1 months). A fixed-bearing implant (Triathlon PKR; Stryker) was used in all cases. The navigation system guided tibial and femoral resections to achieve a hip–knee–ankle angle of 2°–5° varus, while minimizing tibial resection. Pre- and postoperative outcomes were compared for range of motion, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), ability to sit in the seiza position, implant survival, and complications.

Results

Mean knee extension improved from − 5.7° to − 0.6°, flexion from 141.6° to 145.9°, and the mean WOMAC score improved from 41.5 ± 9.9 to 4.9 ± 3.5. The number of patients able to sit in the seiza position increased significantly. Four knees underwent lateral unicompartmental knee arthroplasty for progression of lateral osteoarthritis, and one was converted to total knee arthroplasty for infection. No tibial fractures or implant subsidence occurred. The Kaplan–Meier implant survival rate, with failure defined as reoperation for any cause, was 96.5%.

Conclusions

Alignment-guided medial unicompartmental knee arthroplasty targeting 2°–5° varus using image-free navigation achieved favorable midterm outcomes without major complications.

Level of evidence

Level IV.

内侧单室膝关节置换术术后运动良好,患者满意度高。然而,在人工手术过程中,不准确的骨切除会导致胫骨骨折、植入物下沉或外侧骨关节炎。为了提高准确性,我们使用无图像导航系统进行内侧单室膝关节置换术,术后目标定位为2°-5°内翻。该研究评估了中期临床结果和安全性。材料和方法该单中心回顾性病例系列包括2011年至2021年间144个连续膝关节(男性25个,女性119个,平均年龄72.2岁),接受内侧单室膝关节置换术治疗内翻性骨关节炎,随访至少3年(平均63.1个月)。所有病例均使用固定轴承种植体(Triathlon PKR; Stryker)。导航系统引导胫骨和股骨切除,实现髋关节-膝关节-踝关节2°-5°内翻角,同时尽量减少胫骨切除。对术前和术后结果进行比较,包括活动范围、西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)、以癫痫姿势坐着的能力、植入物存活率和并发症。结果膝关节平均伸度由- 5.7°改善至- 0.6°,膝关节屈曲由141.6°改善至145.9°,WOMAC评分由41.5±9.9改善至4.9±3.5。能够以癫痫姿势坐下的患者数量显著增加。4例膝关节因外侧骨关节炎进展而行外侧单室膝关节置换术,1例因感染而行全膝关节置换术。无胫骨骨折或植入物下沉发生。Kaplan-Meier种植体的存活率为96.5%,失败定义为任何原因的再次手术。结论对齐引导下无图像导航针对2°-5°内翻的内侧单室膝关节置换术中期效果良好,无重大并发症。证据等级:四级。
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引用次数: 0
Medial open-wedge high tibial osteotomy alters sagittal tibial tubercle–trochlear groove distance 内侧开楔胫骨高位截骨改变了矢状面胫骨结节-滑车沟距离
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-13 DOI: 10.1007/s00402-026-06205-7
Sebastian Schmidt, Chilan Bou Ghosson Leite, Domenico Franco, Nicole Krabb, Sascha Gravius, Cale Andrew Jacobs, Christian Lattermann

Purpose

Medial open-wedge high tibial osteotomy (MOWHTO) is widely used to treat varus knee osteoarthritis, but its impact on patellofemoral biomechanics remains incompletely understood. In particular, the sagittal tibial tubercle–trochlear groove (sTT-TG) distance, a novel parameter linked to patellofemoral contact pressure, has not been evaluated in this context. This study aimed to assess changes in sTT-TG following MOWHTO and identify anatomical predictors of its postoperative magnitude.

Methods

In this retrospective study, 34 knees from 33 patients (mean age 36.6 ± 9.5 years, mean BMI 26.2 ± 4.3 kg/m²) undergoing ascending biplanar MOWHTO with pre- and postoperative MRI and radiographs were analyzed. The sTT-TG, Caton–Deschamps Index (CDI), posterior tibial slope (PTS), and tibiofemoral rotation angle (TFRA) were measured. Correlation and multivariable regression analyses were performed to identify predictors of postoperative sTT-TG.

Results

MOWHTO significantly decreased the sTT-TG distance from 6.25 ± 5.34 mm to 3.74 ± 6.81 mm (p = .009), indicating anteriorization of the tibial tubercle. Patellar height (CDI) decreased from 1.14 ± 0.20 to 0.99 ± 0.15 (p < .001), and TFRA was reduced from 4.74 ± 5.54° to 2.62 ± 5.50° (p = .017). Multivariable regression identified preoperative sTT-TG, postoperative medial PTS, and CDI as independent predictors of postoperative sTT-TG (adjusted R² = 0.697). A steeper medial PTS and lower patellar height were associated with greater tibial tubercle anteriorization.

Conclusion

MOWHTO resulted in a significant anteriorization of the tibial tubercle in the sagittal plane. Postoperative sTT-TG is strongly influenced by tibial slope and patellar height, emphasizing the need to account for these factors during surgical planning, particularly in patients with patellofemoral cartilage changes. Future biomechanical studies should explore the clinical relevance of these changes on joint loading.

目的内侧开楔高位胫骨截骨术(MOWHTO)被广泛用于治疗膝内翻性骨关节炎,但其对髌骨生物力学的影响尚不完全清楚。特别是,矢状胫骨结节-滑车沟(sTT-TG)距离,一个与髌股接触压力相关的新参数,尚未在此背景下进行评估。本研究旨在评估MOWHTO术后sTT-TG的变化,并确定其术后大小的解剖学预测因素。方法回顾性分析33例(平均年龄36.6±9.5岁,平均BMI 26.2±4.3 kg/m²)行上升双平面MOWHTO的患者34个膝关节术前、术后MRI及x线片资料。测量sTT-TG、Caton-Deschamps指数(CDI)、胫骨后斜率(PTS)、胫股旋转角(TFRA)。通过相关和多变量回归分析来确定术后sTT-TG的预测因素。结果smowhto使sTT-TG距离由6.25±5.34 mm显著缩短至3.74±6.81 mm (p = 0.009),提示胫骨结节前化。髌骨高度(CDI)由1.14±0.20降至0.99±0.15 (p < 0.001), TFRA由4.74±5.54°降至2.62±5.50°(p = 0.017)。多变量回归发现术前sTT-TG、术后内侧PTS和CDI是术后sTT-TG的独立预测因子(校正R²= 0.697)。更陡的内侧PTS和更低的髌骨高度与更大的胫骨结节前固定有关。结论mowhto对胫骨结节矢状面有明显的前固结作用。术后sTT-TG受胫骨斜率和髌骨高度的强烈影响,强调在手术计划中需要考虑这些因素,特别是在髌股软骨改变的患者中。未来的生物力学研究应探讨这些变化对关节负荷的临床意义。
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引用次数: 0
Influence of different preservation methods on the mechanical in vitro stability of bones: a comparative study using porcine metatarsals 不同保存方法对骨体外力学稳定性的影响:以猪跖骨为例的比较研究
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-13 DOI: 10.1007/s00402-026-06226-2
Martin Bäumlein, Moritz Kühlein-Lehr, Alexander M. König, Volker Ziller, Steffen Ruchholtz, Jürgen R. J. Paletta, Vanessa dos Santos

Introduction

Large quantities of bone specimens are required for the mechanical testing of orthopedic and trauma implants. Currently, fresh-frozen or chemically preserved bones—such as formalin-fixed—are commonly used. This study aimed to evaluate the effects of different conservation methods on mechanical bone stability under standardized conditions.

Materials and methods

Porcine metatarsals were divided into seven groups based on the preservation technique: fresh, fresh-frozen (− 18 °C), frozen with repeated freeze-thaw cycles, vacuum-sealed and refrigerated (4 °C), and chemically fixed using formalin, Thiel-fixation, or glycerol-based methods. All specimens underwent three-point bending tests to assess mechanical stability. Following induced fractures, bones were stabilized with a plate osteosynthesis (DCP® small fragment set, Synthes®, Germany) and retested. Bone mineral density (BMD) was also measured via dual-energy X-ray absorptiometry (DXA).

Results

Results revealed no significant differences in BMD, maximum load, or breaking strength between groups. However, chemically fixed bones—especially formalin and glycerol—showed significantly reduced deformation, indicating increased stiffness. Additionally, chemically fixed specimens exhibited more consistent fracture patterns compared to fresh or physically preserved bones. After osteosynthesis, bones preserved with glycerol showed a significant increase in both maximum load and breaking strength.

Conclusions

While physical preservation methods had no notable effect on mechanical stability, chemically fixed bones exhibited altered deformation characteristics and should therefore be used selectively, depending on the research question.

骨科和创伤植入物的力学测试需要大量的骨标本。目前,新鲜冷冻或化学保存的骨头——比如福尔马林固定物——是常用的。本研究旨在评价标准化条件下不同保护方法对机械骨稳定性的影响。材料与方法将孢素跖骨按保存方法分为7组:新鲜、新鲜冷冻(- 18℃)、反复冻融循环冷冻、真空密封冷藏(4℃)、化学固定(福尔马林法、thil固定法或甘油法)。所有试件均进行三点弯曲试验以评估机械稳定性。诱发骨折后,用钢板固定(DCP®小碎片固定,Synthes®,德国)稳定骨,并重新测试。采用双能x线骨密度仪(DXA)测定骨密度(BMD)。结果显示两组间骨密度、最大负荷和断裂强度无显著差异。然而,化学固定的骨头——尤其是福尔马林和甘油——显示出明显减少变形,表明硬度增加。此外,与新鲜或物理保存的骨头相比,化学固定的标本显示出更一致的骨折模式。植骨后,用甘油保存的骨显示出最大载荷和断裂强度的显著增加。虽然物理保存方法对机械稳定性没有显著影响,但化学固定骨表现出改变的变形特征,因此应根据研究问题有选择地使用。
{"title":"Influence of different preservation methods on the mechanical in vitro stability of bones: a comparative study using porcine metatarsals","authors":"Martin Bäumlein,&nbsp;Moritz Kühlein-Lehr,&nbsp;Alexander M. König,&nbsp;Volker Ziller,&nbsp;Steffen Ruchholtz,&nbsp;Jürgen R. J. Paletta,&nbsp;Vanessa dos Santos","doi":"10.1007/s00402-026-06226-2","DOIUrl":"10.1007/s00402-026-06226-2","url":null,"abstract":"<div><h3>Introduction</h3><p>Large quantities of bone specimens are required for the mechanical testing of orthopedic and trauma implants. Currently, fresh-frozen or chemically preserved bones—such as formalin-fixed—are commonly used. This study aimed to evaluate the effects of different conservation methods on mechanical bone stability under standardized conditions.</p><h3>Materials and methods</h3><p>Porcine metatarsals were divided into seven groups based on the preservation technique: fresh, fresh-frozen (− 18 °C), frozen with repeated freeze-thaw cycles, vacuum-sealed and refrigerated (4 °C), and chemically fixed using formalin, Thiel-fixation, or glycerol-based methods. All specimens underwent three-point bending tests to assess mechanical stability. Following induced fractures, bones were stabilized with a plate osteosynthesis (DCP<sup>®</sup> small fragment set, Synthes<sup>®</sup>, Germany) and retested. Bone mineral density (BMD) was also measured via dual-energy X-ray absorptiometry (DXA).</p><h3>Results</h3><p>Results revealed no significant differences in BMD, maximum load, or breaking strength between groups. However, chemically fixed bones—especially formalin and glycerol—showed significantly reduced deformation, indicating increased stiffness. Additionally, chemically fixed specimens exhibited more consistent fracture patterns compared to fresh or physically preserved bones. After osteosynthesis, bones preserved with glycerol showed a significant increase in both maximum load and breaking strength.</p><h3>Conclusions</h3><p>While physical preservation methods had no notable effect on mechanical stability, chemically fixed bones exhibited altered deformation characteristics and should therefore be used selectively, depending on the research question.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"146 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-026-06226-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147441679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical therapy of conservatively exhausted rhizarthrosis – total joint replacement or resection arthroplasty? A systematic review. 保守性精疲力竭的椎管根关节病的手术治疗——全关节置换术还是关节置换切除术?系统回顾。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-12 DOI: 10.1007/s00402-025-06180-5
Julie Boever, Frank Unglaub, Christian K. Spies, Adrian Cavalcanti Kußmaul, Jan Wulf, Wolfgang Böcker, Ali Ayache

Rhizarthrosis is a common degenerative disorder of the carpometacarpal joint of the thumb, significantly impairing hand function due to pain and loss of mobility. While conservative and joint-preserving measures are the first-line treatment in early stages, advanced disease often requires surgical intervention. The aim of this study was to evaluate and compare the clinical outcomes, functional results, and complication profiles of resection arthroplasty versus latest generations of thumb carpometacarpal joint prostheses. Resection arthroplasty has proven to be a reliable therapy, providing effective pain relief and high patient satisfaction. Latest generations of thumb carpometacarpal joint prostheses demonstrate low rates of loosening and dislocation, along with advantages such as faster rehabilitation, preservation of thumb length, and good functional outcomes. The choice of procedure should be individualized, considering age, activity level, and functional requirements.

根状关节病是一种常见的拇指掌关节退行性疾病,由于疼痛和活动能力丧失,严重损害了手功能。虽然保守和关节保护措施是早期的一线治疗,但晚期疾病通常需要手术干预。本研究的目的是评估和比较切除关节置换术与最新一代拇指腕掌关节假体的临床结果、功能结果和并发症。关节置换术已被证明是一种可靠的治疗方法,提供有效的疼痛缓解和高患者满意度。最新一代的拇指手掌骨关节假体显示出低松动和脱位率,以及更快的康复、保留拇指长度和良好的功能结果等优点。手术的选择应个体化,考虑到年龄、活动水平和功能要求。
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引用次数: 0
Serotonergic antidepressants are associated with increased bleeding events within 30-days after total shoulder arthroplasty: a propensity-matched analysis of 54,291 patients 5 -羟色胺类抗抑郁药与全肩关节置换术后30天内出血事件增加有关:54,291例患者的倾向匹配分析
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-12 DOI: 10.1007/s00402-026-06254-y
John T. Strony, Andrew J. Moyal, Jeremy M. Adelstein, Robert J. Burkhart, Anthony M. Imbrogno, Rayyan Abid, Robert J. Gillespie, Raymond E. Chen

Introduction

Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are associated with bleeding events following orthopaedic surgery. However, their effect on total shoulder arthroplasty (TSA) outcomes is unknown.

Methods

Patients undergoing primary anatomic or reverse TSA in the United States were identified in the TriNetX database using Current Procedural Terminology (CPT) and International Classification of Disease (ICD-10) codes. TSA for fracture was excluded. Two cohorts were created based on preoperative serotonergic antidepressant use. Cohorts were matched to 14 demographic, comorbidity, laboratory and medication parameters. Outcomes were analyzed at one week, one month and three months postoperatively. Significance was set at p < 0.05.

Results

7,374 matched patients were included per cohort. The SSRI/SNRI cohort had significantly higher odds for post-hemorrhagic anemia and transfusion on the day of surgery (Anemia - OR 1.50, 95%CI 1.28–1.76; Transfusion - OR 2.55, 95%CI 1.27–5.13), at seven-days post-op (Anemia - OR 2.78, 95%CI 1.68–4.58; Transfusion - OR 2.58, 95%CI 1.39–4.79) and at one month post-op (Anemia - OR 2.73, 95%CI 1.37–5.46; Transfusion - OR 2.31, 95%CI 1.09–4.88). From one through three-months post-operatively, the two cohorts did not differ in rates of postoperative anemia, hematoma/hemorrhage, or reoperation.

Conclusions

Serotonergic antidepressants were associated with a higher rate of bleeding events within 30 days postoperatively after TSA. These results are seen even when propensity matching for PT/PTT and platelet function. Complications normalize after 30 days and do not appear to pose a long-term risk.

选择性血清素再摄取抑制剂(SSRIs)和血清素-去甲肾上腺素再摄取抑制剂(SNRIs)与骨科手术后出血事件相关。然而,它们对全肩关节置换术(TSA)结果的影响尚不清楚。方法使用现行程序术语(CPT)和国际疾病分类(ICD-10)代码在TriNetX数据库中识别在美国接受初级解剖或反向TSA的患者。排除骨折TSA。根据术前血清素能抗抑郁药的使用创建了两个队列。队列与14个人口统计学、合并症、实验室和药物参数相匹配。分别于术后1周、1个月和3个月进行结果分析。p <; 0.05为显著性。结果每个队列纳入7374例匹配患者。SSRI/SNRI队列在手术当天(贫血- OR 1.50, 95%CI 1.28-1.76;输血- OR 2.55, 95%CI 1.27-5.13)、术后7天(贫血- OR 2.78, 95%CI 1.68-4.58;输血- OR 2.58, 95%CI 1.39-4.79)和术后1个月(贫血- OR 2.73, 95%CI 1.37-5.46;输血- OR 2.31, 95%CI 1.09-4.88)出血性贫血和输血的几率显著较高。从术后1个月到3个月,两个队列在术后贫血、血肿/出血或再手术的发生率上没有差异。结论血清素能抗抑郁药与TSA术后30天内出血事件发生率升高有关。这些结果甚至在PT/PTT和血小板功能倾向匹配时也能看到。并发症在30天后恢复正常,似乎不会造成长期风险。
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引用次数: 0
Pre-operative activity level and a sport or recreation injury mechanism are associated with 2-year clinical outcome after proximal hamstring tendon repair 术前活动水平和运动或娱乐损伤机制与近端腘绳肌腱修复后2年的临床结果相关
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2026-03-12 DOI: 10.1007/s00402-026-06252-0
Jay Ebert, Peter Edwards, Sven Klinken, Brendan Ricciardo, Peter Annear, Peter D’Alessandro

Introduction

Surgical repair of proximal hamstring tendon ruptures has demonstrated encouraging outcomes and satisfaction rates, superior to non-operative management. This study sought to investigate injury, surgical and post-operative factors associated with clinical outcome and satisfaction 2-years after proximal hamstring tendon repair of acute tendon injuries.

Methods

This study included 59 patients undergoing proximal hamstring repair for acute tendon ruptures. Clinical assessment pre-operatively and 2-years post-operatively included the Perth Hamstring Assessment Tool (PHAT), Lower Extremity Functional Scale (LEFS) and Tegner Activity Scale (TAS). Regression analysis assessed the contribution of pre-operative patient (age, sex, body mass index, TAS), injury/surgery (time from injury to surgery, injury mechanism, semimembranosus and conjoint tendon retraction) and post-operative (peak isokinetic knee flexor strength) variables, to the 2-year PHAT and reporting complete satisfaction.

Results

From baseline to 2-years, the PHAT improved by 47.1 points (95% CI, 41.9 to 52.3; p < 0.001), with 97.1% of patients meeting the PHAT minimal important change of 8.6 points by 2 years post-surgery. Furthermore, the LEFS improved by 44.5 points (95% CI, 39.9 to 49.1; p < 0.001) and TAS by 2.6 points (95% CI, 2.1 to 3.2; p < 0.001). Forty-six (78.0%) patients were ‘very satisfied’ with their 2-year outcome. Univariable analysis indicated that age (p = 0.004), baseline TAS (p = 0.006), a sport/recreation injury mechanism (p < 0.001) and 6-month normalized knee flexor torque (p = 0.030) were associated with the 2-year PHAT. In the final multivariable model, only the baseline TAS (p = 0.021) and a sport/recreation injury mechanism (p = 0.001) remained. No variable was significantly associated with being ‘very satisfied’ with 2-year surgical outcome.

Conclusions

Clinical scores improved significantly from baseline to 2 years after proximal hamstring repair. While pre-operative TAS and a sport/recreation injury mechanism were associated with the 2-year PHAT, no variables were associated with being ‘very satisfied’ with the 2-year outcome.

Level of evidence

Prospective cohort study, Level of evidence 3.

手术修复近端腘绳肌腱断裂已显示出令人鼓舞的结果和满意率,优于非手术治疗。本研究旨在探讨损伤、手术和术后因素与急性肌腱损伤近端肌腱修复术后2年的临床结果和满意度相关。方法对59例急性肌腱断裂行近端腘绳肌修复术的患者进行研究。术前和术后2年的临床评估包括Perth腘绳肌评估工具(PHAT)、下肢功能量表(LEFS)和Tegner活动量表(TAS)。回归分析评估了术前患者(年龄、性别、体重指数、TAS)、损伤/手术(从损伤到手术的时间、损伤机制、半膜肌和联合肌腱牵伸)和术后(峰值等速膝关节屈肌力量)变量对2年PHAT的贡献,并报告了完全满意度。结果从基线到2年,PHAT改善了47.1分(95% CI, 41.9至52.3;p < 0.001), 97.1%的患者在术后2年达到PHAT最小重要变化8.6分。此外,LEFS提高了44.5分(95% CI, 39.9至49.1;p < 0.001), TAS提高了2.6分(95% CI, 2.1至3.2;p < 0.001)。46例(78.0%)患者对其2年预后“非常满意”。单变量分析表明,年龄(p = 0.004)、基线TAS (p = 0.006)、运动/娱乐损伤机制(p < 0.001)和6个月正常膝关节屈曲扭矩(p = 0.030)与2年PHAT相关。在最后的多变量模型中,只剩下基线TAS (p = 0.021)和运动/娱乐损伤机制(p = 0.001)。没有变量与“非常满意”的2年手术结果显著相关。结论近端腘绳肌修复术后2年临床评分显著提高。虽然术前TAS和运动/娱乐损伤机制与2年的PHAT相关,但没有变量与2年的结果“非常满意”相关。证据水平:前瞻性队列研究,证据水平为3。
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引用次数: 0
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Archives of Orthopaedic and Trauma Surgery
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