首页 > 最新文献

Archives of Orthopaedic and Trauma Surgery最新文献

英文 中文
Scapho-metacarpal dual mobility prosthesis for TMC-1 joint salvage: technical insights.
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-025-05751-w
Julia Glaser, Martin Aman, Thomas Krohn, Joris Duerinckx, Benjamin Panzram, Leila Harhaus

Introduction: Rhizarthrosis, or osteoarthritis of the trapeziometacarpal joint, predominantly affects women over 50, with up to 30% experiencing some degree of arthritis in this joint. Traditional surgical approaches, such as trapeziectomy with ligament reconstruction, can result in some patients in persistent pain or limited functionality. TMC ball-in-socket arthroplasty, with a cup placed in the distal scaphoid, offers a promising alternative to traditional arthrodesis or resection-suspension arthroplasty.

Materials and methods: This study involved 11 patients with treated 13 hands who had persistent symptoms after previous TMC-1 surgeries. Procedures included a bilateral scaphometacarpal implantation in two cases. Main symptoms were pain, thumb shortening, and reduced grip strength. The Touch® ball-in-socket prosthesis was used, with specific considerations for implant selection, surgical steps and customization based on the patient-specific case.

Results: We included 11 patients with 13 thumbs, with a mean follow-up time of 16 months (range: 4-49 months). All patients showed significant improvements in thumb function. Grip strength, as measured by dynamometry, showed an average recovery to 80-90% of the contralateral side. Thumb opposition according to the Kapandji score averaged 9 out of 10. Radiographs demonstrated good osseointegration of the implants, with no signs of prosthetic loosening or dislocation. Complications included one case of persistent mild hypesthesia of the radial nerve's superficial branch, which did not impair function, and one scaphoid fracture 4 weeks post-implantation during cast immobilization.

Conclusion: The scapho-metacarpal dual mobility prosthesis is a feasible and effective option for patients with persistent TMC-1 symptoms after failed surgeries. It uniquely preserves both thumb mobility and length, unlike alternatives like arthrodesis and tendon suspensionplasty, which remain options if the prosthesis fails. Further research and long-term studies are necessary to determine the definitive role of this approach in complex TMC-1 cases.

{"title":"Scapho-metacarpal dual mobility prosthesis for TMC-1 joint salvage: technical insights.","authors":"Julia Glaser, Martin Aman, Thomas Krohn, Joris Duerinckx, Benjamin Panzram, Leila Harhaus","doi":"10.1007/s00402-025-05751-w","DOIUrl":"https://doi.org/10.1007/s00402-025-05751-w","url":null,"abstract":"<p><strong>Introduction: </strong>Rhizarthrosis, or osteoarthritis of the trapeziometacarpal joint, predominantly affects women over 50, with up to 30% experiencing some degree of arthritis in this joint. Traditional surgical approaches, such as trapeziectomy with ligament reconstruction, can result in some patients in persistent pain or limited functionality. TMC ball-in-socket arthroplasty, with a cup placed in the distal scaphoid, offers a promising alternative to traditional arthrodesis or resection-suspension arthroplasty.</p><p><strong>Materials and methods: </strong>This study involved 11 patients with treated 13 hands who had persistent symptoms after previous TMC-1 surgeries. Procedures included a bilateral scaphometacarpal implantation in two cases. Main symptoms were pain, thumb shortening, and reduced grip strength. The Touch<sup>®</sup> ball-in-socket prosthesis was used, with specific considerations for implant selection, surgical steps and customization based on the patient-specific case.</p><p><strong>Results: </strong>We included 11 patients with 13 thumbs, with a mean follow-up time of 16 months (range: 4-49 months). All patients showed significant improvements in thumb function. Grip strength, as measured by dynamometry, showed an average recovery to 80-90% of the contralateral side. Thumb opposition according to the Kapandji score averaged 9 out of 10. Radiographs demonstrated good osseointegration of the implants, with no signs of prosthetic loosening or dislocation. Complications included one case of persistent mild hypesthesia of the radial nerve's superficial branch, which did not impair function, and one scaphoid fracture 4 weeks post-implantation during cast immobilization.</p><p><strong>Conclusion: </strong>The scapho-metacarpal dual mobility prosthesis is a feasible and effective option for patients with persistent TMC-1 symptoms after failed surgeries. It uniquely preserves both thumb mobility and length, unlike alternatives like arthrodesis and tendon suspensionplasty, which remain options if the prosthesis fails. Further research and long-term studies are necessary to determine the definitive role of this approach in complex TMC-1 cases.</p>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":"128"},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and magnetic resonance imaging outcome after proximal hamstring tendon repair at mean 3 years follow-up.
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05684-w
Carlo Sgustav, Lucca Lacheta, Ulrich Stöckle, Doruk Akgün, Dominik Geisel, Hi-Un Park, Adrian Marth, Suchung Kim

Purpose: The purpose of this study was to assess clinical and radiological outcome in patients after proximal hamstring tendon repair. We hypothesized that there is a significant correlation among subjective clinical outcome and interlimb asymmetries in muscle strength, fatty infiltration, and hamstring volume.

Methods: This retrospective monocentric case series included patients with surgical repair after proximal hamstring tendon rupture. Clinical outcome was assessed utilizing: Healthy Days Core Module (CDC HRQOL-4), numeric pain rating scale (NRS), modified Harris Hip Score (mHHS), Tegner Activity Scale (TAS), return to pre-injury activity level (RTPA), and patient satisfaction score. Postoperative hamstring strength was measured using a handheld dynamometer and radiological outcome was determined by postoperative magnetic resonance imaging (MRI).

Results: Twenty-seven patients with a mean age of 51.2 (± 12.6) years were available for follow-up at a mean of 41.11 (± 18.4) months. Patients state a mean of 10.6 (± 11.5) days in the unhealthy days (UHD) index and 88.9% show "good health" in the simple summary score (SSS). Mean subjective outcome scores were as follows: NRS 1.1 (± 2.4), mHHS 90.3 (± 14.8) and TAS 5.7 (± 2.2). A total of 59.3% RTPA and 88.9% state to be somewhat or very satisfied with their surgery. Mean interlimb strength ratio was 0.88 (± 0.21). MRI demonstrated a fully restored muscle-tendon unit, significantly greater fatty infiltration in the injured hamstrings (p = 0.009, d = 0.558), and a mean interlimb hamstring volume ratio of 0.94 (± 0.11). With respect to the 10% benchmark, patients had no significant asymmetries in muscle strength (p = 0.677, d = 0.084) or hamstring volume (p = 0.102, d = - 0.34). Correlation analysis revealed moderate correlation among asymmetries in strength and volume (p = 0.073, r = 0.373). In patients with the operated side inferior to the healthy side (n = 15), there was strong correlation among asymmetries in strength and volume (p = 0.002, r = 0.725). Statistically significant correlation was found between interlimb muscle volume atrophy and increase in fatty infiltration (p = 0.015, r = 0.481).

Conclusion: Proximal hamstring repair results in good clinical outcome with satisfactory recovery of hamstring strength and volume. Interlimb asymmetries, in terms of muscle strength, fatty infiltration, and hamstring volume do not correlate with clinical outcome.

Study type: Retrospective cohort study; Level of evidence, 3.

{"title":"Clinical and magnetic resonance imaging outcome after proximal hamstring tendon repair at mean 3 years follow-up.","authors":"Carlo Sgustav, Lucca Lacheta, Ulrich Stöckle, Doruk Akgün, Dominik Geisel, Hi-Un Park, Adrian Marth, Suchung Kim","doi":"10.1007/s00402-024-05684-w","DOIUrl":"https://doi.org/10.1007/s00402-024-05684-w","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to assess clinical and radiological outcome in patients after proximal hamstring tendon repair. We hypothesized that there is a significant correlation among subjective clinical outcome and interlimb asymmetries in muscle strength, fatty infiltration, and hamstring volume.</p><p><strong>Methods: </strong>This retrospective monocentric case series included patients with surgical repair after proximal hamstring tendon rupture. Clinical outcome was assessed utilizing: Healthy Days Core Module (CDC HRQOL-4), numeric pain rating scale (NRS), modified Harris Hip Score (mHHS), Tegner Activity Scale (TAS), return to pre-injury activity level (RTPA), and patient satisfaction score. Postoperative hamstring strength was measured using a handheld dynamometer and radiological outcome was determined by postoperative magnetic resonance imaging (MRI).</p><p><strong>Results: </strong>Twenty-seven patients with a mean age of 51.2 (± 12.6) years were available for follow-up at a mean of 41.11 (± 18.4) months. Patients state a mean of 10.6 (± 11.5) days in the unhealthy days (UHD) index and 88.9% show \"good health\" in the simple summary score (SSS). Mean subjective outcome scores were as follows: NRS 1.1 (± 2.4), mHHS 90.3 (± 14.8) and TAS 5.7 (± 2.2). A total of 59.3% RTPA and 88.9% state to be somewhat or very satisfied with their surgery. Mean interlimb strength ratio was 0.88 (± 0.21). MRI demonstrated a fully restored muscle-tendon unit, significantly greater fatty infiltration in the injured hamstrings (p = 0.009, d = 0.558), and a mean interlimb hamstring volume ratio of 0.94 (± 0.11). With respect to the 10% benchmark, patients had no significant asymmetries in muscle strength (p = 0.677, d = 0.084) or hamstring volume (p = 0.102, d = - 0.34). Correlation analysis revealed moderate correlation among asymmetries in strength and volume (p = 0.073, r = 0.373). In patients with the operated side inferior to the healthy side (n = 15), there was strong correlation among asymmetries in strength and volume (p = 0.002, r = 0.725). Statistically significant correlation was found between interlimb muscle volume atrophy and increase in fatty infiltration (p = 0.015, r = 0.481).</p><p><strong>Conclusion: </strong>Proximal hamstring repair results in good clinical outcome with satisfactory recovery of hamstring strength and volume. Interlimb asymmetries, in terms of muscle strength, fatty infiltration, and hamstring volume do not correlate with clinical outcome.</p><p><strong>Study type: </strong>Retrospective cohort study; Level of evidence, 3.</p>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":"130"},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bipolar vs. monopolar sealer in decreasing blood loss and transfusion rate in patients undergoing two-stage exchange in infected total knee arthroplasty: propensity score-matched study.
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05685-9
Giovanni Balato, Tiziana Ascione, Donato Di Gennaro, Enrico Festa, Domenico De Mauro, Viviana Lo Conte, Massimo Mariconda

Background: Two-stage revision in infected total knee arthroplasty increases the risk of blood loss and the need for transfusion. The present study aimed to test the hemostatic efficacy of a bipolar sealer to reduce blood loss and transfusion requirements after the first stage in patients affected by peri-prosthetic knee infections.

Methods: Twenty-four patients undergoing 2-stage arthroplasty for infected TKA using a bipolar sealer (Haemodiss, Kylix, Naples, IT) were compared with 24 patients of a historical control group in which conventional electrocautery was used. Transfusion data, clinical information, and operative data were evaluated. The primary outcome measure was estimated blood loss at the time of the lowest hemoglobin level (nadir). The secondary outcome measures were the transfusion requirement and the number of units transfused.

Results: The total blood loss was significantly lower in the prospective bipolar sealer group than the control group (1.19 (IQR 1.03-1.93) vs. 1.75 (IQR 1.13-2.07) L; p = 0.022). The transfusion rate was 8% in the bipolar sealer group, whereas 33% in the control group (p = 0.036). Furthermore, the mean number of blood units transfused was higher in the control group (0.4 ± 0.7 vs. 0.08 ± 0.3; p < 0.01). The Baseline Hematocrit and Operative time were directly associated with blood loss, whereas the bipolar use represented inverse predictor using multiple linear regression analysis.

Conclusion: After the first stage of a two-stage exchange for periprosthetic knee infection, several factors influence postoperative blood loss, including preoperative HCT level and operative time. The bipolar sealer effectively supports hemostasis, thus reducing blood loss and the need for transfusions.

{"title":"Bipolar vs. monopolar sealer in decreasing blood loss and transfusion rate in patients undergoing two-stage exchange in infected total knee arthroplasty: propensity score-matched study.","authors":"Giovanni Balato, Tiziana Ascione, Donato Di Gennaro, Enrico Festa, Domenico De Mauro, Viviana Lo Conte, Massimo Mariconda","doi":"10.1007/s00402-024-05685-9","DOIUrl":"https://doi.org/10.1007/s00402-024-05685-9","url":null,"abstract":"<p><strong>Background: </strong>Two-stage revision in infected total knee arthroplasty increases the risk of blood loss and the need for transfusion. The present study aimed to test the hemostatic efficacy of a bipolar sealer to reduce blood loss and transfusion requirements after the first stage in patients affected by peri-prosthetic knee infections.</p><p><strong>Methods: </strong>Twenty-four patients undergoing 2-stage arthroplasty for infected TKA using a bipolar sealer (Haemodiss, Kylix, Naples, IT) were compared with 24 patients of a historical control group in which conventional electrocautery was used. Transfusion data, clinical information, and operative data were evaluated. The primary outcome measure was estimated blood loss at the time of the lowest hemoglobin level (nadir). The secondary outcome measures were the transfusion requirement and the number of units transfused.</p><p><strong>Results: </strong>The total blood loss was significantly lower in the prospective bipolar sealer group than the control group (1.19 (IQR 1.03-1.93) vs. 1.75 (IQR 1.13-2.07) L; p = 0.022). The transfusion rate was 8% in the bipolar sealer group, whereas 33% in the control group (p = 0.036). Furthermore, the mean number of blood units transfused was higher in the control group (0.4 ± 0.7 vs. 0.08 ± 0.3; p < 0.01). The Baseline Hematocrit and Operative time were directly associated with blood loss, whereas the bipolar use represented inverse predictor using multiple linear regression analysis.</p><p><strong>Conclusion: </strong>After the first stage of a two-stage exchange for periprosthetic knee infection, several factors influence postoperative blood loss, including preoperative HCT level and operative time. The bipolar sealer effectively supports hemostasis, thus reducing blood loss and the need for transfusions.</p>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":"129"},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The single antegrade sling graft: a novel hamstring autograft technique for combined anterior cruciate ligament and anterolateral ligament reconstruction.
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05697-5
Ahmed Rabie, Mohamed S Arafa, Mahmoud Bahloul, Ahmed Abdelbadie

Introduction: As a result of increased incidence of anterior cruciate ligament (ACL) injury in young athletes, there is a rise in the indications surgical ACL reconstruction procedures. The value of anterolateral ligament (ALL) reconstruction emerges as a proposed solution to prevent graft failures and improve stability in this high demanding category of patients. The purpose of this study is to present our experience with a novel hamstring auto-grafting technique, the single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL using autologous gracilis (GR) and semitendinosus (ST) grafts utilizing a single femoral tunnel and double tibial tunnels.

Materials and methods: From January 2020 to December 2021, 21 soccer players were operated utilizing the SASG technique, a modification of the technique of SANTI study group. Inclusion criteria were participating in pivoting sport, high-grade pivot shift examination (Grade 2-3), and evidence of a lateral femoral notch sign or Segond's fracture on preoperative imaging. Patients were assessed for 2 years postoperatively by Lachman's test for anteroposterior laxity and pivot shift test for rotational laxity. The postoperative outcomes were assessed by Tegner-Lysholm and International knee documentation committee scores. Also, the postoperative complications such as stiffness, infection and graft failure were reported.

Results: 21 male soccer players with a mean age 26.4 years were included in this study. After 2 years follow up there was a statistically significant improvement in the both post-operative functional scores, P value < 0.001. Fifteen patients (71.4%) could return to their preoperative sport activity level with no giving-way symptoms. Only one case of graft failure was reported in the follow up.

Conclusions: The single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL yielded good results in terms of stability and return to sports. The technique is reproducible, and results are comparable to the available published literature.

{"title":"The single antegrade sling graft: a novel hamstring autograft technique for combined anterior cruciate ligament and anterolateral ligament reconstruction.","authors":"Ahmed Rabie, Mohamed S Arafa, Mahmoud Bahloul, Ahmed Abdelbadie","doi":"10.1007/s00402-024-05697-5","DOIUrl":"https://doi.org/10.1007/s00402-024-05697-5","url":null,"abstract":"<p><strong>Introduction: </strong>As a result of increased incidence of anterior cruciate ligament (ACL) injury in young athletes, there is a rise in the indications surgical ACL reconstruction procedures. The value of anterolateral ligament (ALL) reconstruction emerges as a proposed solution to prevent graft failures and improve stability in this high demanding category of patients. The purpose of this study is to present our experience with a novel hamstring auto-grafting technique, the single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL using autologous gracilis (GR) and semitendinosus (ST) grafts utilizing a single femoral tunnel and double tibial tunnels.</p><p><strong>Materials and methods: </strong>From January 2020 to December 2021, 21 soccer players were operated utilizing the SASG technique, a modification of the technique of SANTI study group. Inclusion criteria were participating in pivoting sport, high-grade pivot shift examination (Grade 2-3), and evidence of a lateral femoral notch sign or Segond's fracture on preoperative imaging. Patients were assessed for 2 years postoperatively by Lachman's test for anteroposterior laxity and pivot shift test for rotational laxity. The postoperative outcomes were assessed by Tegner-Lysholm and International knee documentation committee scores. Also, the postoperative complications such as stiffness, infection and graft failure were reported.</p><p><strong>Results: </strong>21 male soccer players with a mean age 26.4 years were included in this study. After 2 years follow up there was a statistically significant improvement in the both post-operative functional scores, P value < 0.001. Fifteen patients (71.4%) could return to their preoperative sport activity level with no giving-way symptoms. Only one case of graft failure was reported in the follow up.</p><p><strong>Conclusions: </strong>The single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL yielded good results in terms of stability and return to sports. The technique is reproducible, and results are comparable to the available published literature.</p>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":"126"},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total joint arthroplasty of the thumb CMC joint.
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1007/s00402-024-05663-1
Jiří Jurča, Martin Vlach, Vojtěch Havlas

Purpose of the study: Rhizarthrosis-osteoarthritis of the thumb carpometacarpal (CMC) joint is usually a primary idiopathic disease. Total joint arthroplasty (TJA) is one of the surgical treatment options for symptomatic advanced thumb CMC arthritis. This retrospective study aims to evaluate the mid-term functional and radiological results of TJA with the minimum follow-up period of 3 years after the surgery.

Material and methods: Presented are the results of 136 total trapeziometacarpal joint replacements in the group of 105 patients consisted of 96 women and 9 men. Used prostheses were ELiS® implant (27 cases), Ivory® implant (42 cases), Touch® Dual mobility (67 cases). The follow-up period was minimally 3 years postoperatively. In all the patients, along with range of motion and radiologic evaluation of implant position, the function and pain of operated joint were evaluated using DASH and VAS score at regular intervals pre- and postoperatively.

Results: At a mean of 85 months (range 38-126 months) post-operatively, patients in 116 cases (85%) reported full satisfaction and absence of symptoms and difficulties. In 12 cases (9%) some slight residual post-exercise pain was reported. In eight cases (6%) patients suffered from episodic rest-pain, but with a lower intensity than in the preoperative period. Postoperatively, the patients declared subjective improvement in hand function. The total DASH score and VAS score decreased in all patients, while ROM increased. The course of all of TJA surgeries was complication-free. Five patients needed revision surgery. In two patients a dislocation has occurred and in three cases a loosening of the cup's implant was reported. The most frequent postoperative complication was the occurrence of transient paraesthesias of the thumb in eight cases (6%).

Conclusions: TJA is the method of choice in management of advanced symptomatic osteoarthritis of the thumb CMC joint. Mastering surgical technique, TJA represents safe and effective treatment method in advanced degenerative changes of the thumb CMC joint and it's benefits exceed possible perioperative and postoperative risks.

{"title":"Total joint arthroplasty of the thumb CMC joint.","authors":"Jiří Jurča, Martin Vlach, Vojtěch Havlas","doi":"10.1007/s00402-024-05663-1","DOIUrl":"https://doi.org/10.1007/s00402-024-05663-1","url":null,"abstract":"<p><strong>Purpose of the study: </strong>Rhizarthrosis-osteoarthritis of the thumb carpometacarpal (CMC) joint is usually a primary idiopathic disease. Total joint arthroplasty (TJA) is one of the surgical treatment options for symptomatic advanced thumb CMC arthritis. This retrospective study aims to evaluate the mid-term functional and radiological results of TJA with the minimum follow-up period of 3 years after the surgery.</p><p><strong>Material and methods: </strong>Presented are the results of 136 total trapeziometacarpal joint replacements in the group of 105 patients consisted of 96 women and 9 men. Used prostheses were ELiS<sup>®</sup> implant (27 cases), Ivory<sup>®</sup> implant (42 cases), Touch<sup>®</sup> Dual mobility (67 cases). The follow-up period was minimally 3 years postoperatively. In all the patients, along with range of motion and radiologic evaluation of implant position, the function and pain of operated joint were evaluated using DASH and VAS score at regular intervals pre- and postoperatively.</p><p><strong>Results: </strong>At a mean of 85 months (range 38-126 months) post-operatively, patients in 116 cases (85%) reported full satisfaction and absence of symptoms and difficulties. In 12 cases (9%) some slight residual post-exercise pain was reported. In eight cases (6%) patients suffered from episodic rest-pain, but with a lower intensity than in the preoperative period. Postoperatively, the patients declared subjective improvement in hand function. The total DASH score and VAS score decreased in all patients, while ROM increased. The course of all of TJA surgeries was complication-free. Five patients needed revision surgery. In two patients a dislocation has occurred and in three cases a loosening of the cup's implant was reported. The most frequent postoperative complication was the occurrence of transient paraesthesias of the thumb in eight cases (6%).</p><p><strong>Conclusions: </strong>TJA is the method of choice in management of advanced symptomatic osteoarthritis of the thumb CMC joint. Mastering surgical technique, TJA represents safe and effective treatment method in advanced degenerative changes of the thumb CMC joint and it's benefits exceed possible perioperative and postoperative risks.</p>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":"127"},"PeriodicalIF":2.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presurgical anxiety and acute postsurgical pain predict worse chronic pain profiles after total knee/hip arthroplasty
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05681-z
Ana Cristina Paredes, Patrício Costa, Armando Almeida, Patrícia R. Pinto

Introduction

Total joint arthroplasties generally achieve good outcomes, but chronic pain and disability are a significant burden after these interventions. Acknowledging relevant risk factors can inform preventive strategies. This study aimed to identify chronic pain profiles 6 months after arthroplasty using the ICD-11 (International Classification of Diseases) classification and to find pre and postsurgical predictors of these profiles.

Materials and methods

Patients undergoing total knee/hip arthroplasty (n = 209, female = 54.5%) were assessed before surgery, 48 h and 6 months postsurgery for sociodemographic, pain-related, disability and psychological characteristics. K-means-constrained cluster analysis identified chronic pain profiles based on 6-month pain intensity, pain interference and disability. Chi-square tests or one-way ANOVA explored between-cluster differences. Multinomial regression identified predictors of cluster membership. Separate models analyzed presurgical (model 1), postsurgical (model 2) and a combination of previously significant pre and postsurgical (model 3) variables.

Results

A three-cluster solution was selected, translating increasingly worse chronic pain severity: cluster 1 (C1, n = 129), cluster 2 (C2, n = 60) and cluster 3 (C3, n = 20). There were presurgical differences among clusters in the presence of other painful sites (p = 0.013, ϕc = 0.20), pain interference (p = 0.038, η2 = 0.031), disability (p = 0.020, η2 = 0.037), pain catastrophizing (p = 0.019, η2 = 0.060), anxiety (p < 0.001, η2 = 0.087), depression (p = 0.017; η2 = 0.039), self-efficacy (p = 0.018, η2 = 0.038) and satisfaction with life (p = 0.034, η2 = 0.032), postsurgical pain frequency (p = 0.003, ϕc = 0.243) and intensity (p < 0.001, η2 = 0.101). In model 1, disability predicted C2 (OR = 1.040) and anxiety predicted C3 (OR = 1.154) membership. In model 2, pain intensity predicted C3 (OR = 1.690) membership. In model 3, presurgical anxiety predicted C3 (OR = 1.181) and postsurgical pain intensity predicted C2 (OR = 1.234) and C3 (OR = 1.679) membership.

Conclusions

Most patients had low chronic pain severity at 6 months, but a relevant percentage exhibited poor outcomes. Membership to different outcome profiles was predicted by presurgical anxiety and acute postsurgical pain. These seem promising targets to prevent pain chronification that should be optimized for better surgical outcomes.

{"title":"Presurgical anxiety and acute postsurgical pain predict worse chronic pain profiles after total knee/hip arthroplasty","authors":"Ana Cristina Paredes,&nbsp;Patrício Costa,&nbsp;Armando Almeida,&nbsp;Patrícia R. Pinto","doi":"10.1007/s00402-024-05681-z","DOIUrl":"10.1007/s00402-024-05681-z","url":null,"abstract":"<div><h3>Introduction</h3><p>Total joint arthroplasties generally achieve good outcomes, but chronic pain and disability are a significant burden after these interventions. Acknowledging relevant risk factors can inform preventive strategies. This study aimed to identify chronic pain profiles 6 months after arthroplasty using the ICD-11 (International Classification of Diseases) classification and to find pre and postsurgical predictors of these profiles.</p><h3>Materials and methods</h3><p>Patients undergoing total knee/hip arthroplasty (<i>n</i> = 209, female = 54.5%) were assessed before surgery, 48 h and 6 months postsurgery for sociodemographic, pain-related, disability and psychological characteristics. K-means-constrained cluster analysis identified chronic pain profiles based on 6-month pain intensity, pain interference and disability. Chi-square tests or one-way ANOVA explored between-cluster differences. Multinomial regression identified predictors of cluster membership. Separate models analyzed presurgical (model 1), postsurgical (model 2) and a combination of previously significant pre and postsurgical (model 3) variables.</p><h3>Results</h3><p>A three-cluster solution was selected, translating increasingly worse chronic pain severity: cluster 1 (C1, <i>n</i> = 129), cluster 2 (C2, <i>n</i> = 60) and cluster 3 (C3, <i>n</i> = 20). There were presurgical differences among clusters in the presence of other painful sites (<i>p</i> = 0.013, ϕc = 0.20), pain interference (<i>p</i> = 0.038, η<sup>2</sup> = 0.031), disability (<i>p</i> = 0.020, η<sup>2</sup> = 0.037), pain catastrophizing (<i>p</i> = 0.019, η<sup>2</sup> = 0.060), anxiety (<i>p</i> &lt; 0.001, η<sup>2</sup> = 0.087), depression (<i>p</i> = 0.017; η<sup>2</sup> = 0.039), self-efficacy (<i>p</i> = 0.018, η<sup>2</sup> = 0.038) and satisfaction with life (<i>p</i> = 0.034, η<sup>2</sup> = 0.032), postsurgical pain frequency (<i>p</i> = 0.003, ϕc = 0.243) and intensity (<i>p</i> &lt; 0.001, η<sup>2</sup> = 0.101). In model 1, disability predicted C2 (OR = 1.040) and anxiety predicted C3 (OR = 1.154) membership. In model 2, pain intensity predicted C3 (OR = 1.690) membership. In model 3, presurgical anxiety predicted C3 (OR = 1.181) and postsurgical pain intensity predicted C2 (OR = 1.234) and C3 (OR = 1.679) membership.</p><h3>Conclusions</h3><p>Most patients had low chronic pain severity at 6 months, but a relevant percentage exhibited poor outcomes. Membership to different outcome profiles was predicted by presurgical anxiety and acute postsurgical pain. These seem promising targets to prevent pain chronification that should be optimized for better surgical outcomes.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabesity is associated with a worse joint specific functional outcome following primary total knee replacement
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05704-9
Jack Lovie, Nicholas D. Clement, Deborah MacDonald, Issaq Ahmed

Introduction

The combined effect of diabetes mellitus and obesity (Diabesity) on total knee replacement (TKR) outcomes is unclear. This study aimed to assess whether diabesity influenced functional outcomes and complication rate following primary TKR.

Materials and methods

This case-controlled study compared the independent effects of obesity, diabetes, and diabesity on TKR outcomes. Data were collected pre-operatively and 12 months post-operatively from a single study centre. Outcomes included Oxford Knee Score (OKS), EuroQol 5-dimensions (Eq. 5D), post-operative satisfaction and complication rate.

Results

There were 2577 TKRs in the cohort, of which 244 (9.5%) had diabesity. Diabesity was independently associated with reduced pre-operative OKS (-1.14 points, 95% CI -1.97 to -0.31, p = 0.007) and OKS improvement (-2.37 points, 95% CI -3.11 to -1.62, p < 0.001). Obesity was also independently associated with worse pre-operative OKS (-0.78 points, 95% CI -1.28 to -0.27, p = 0.003) and OKS improvement (-0.81 points, 95% CI -1.26 to -0.35, p = 0.001). Both diabesity (-0.05 points, 95% CI -0.08 to -0.02, p = 0.003) and obesity (-0.02 points, 95% CI -0.04 to 0.00, p = 0.039) were associated with worse pre-operative Eq. 5D score. Patients with diabesity reported reduced post-operative satisfaction due to obesity independently (OR 0.75, 95% CI 0.56 to 1.00, p = 0.048). Diabesity was not independently associated with post-operative complications.

Conclusions

Diabesity was independently associated with a worse knee-specific function and Eq. 5D score pre-operatively, and diminished joint specific functional improvement following TKR. Patients with diabesity also experienced reduced post-operative satisfaction due to obesity independently.

{"title":"Diabesity is associated with a worse joint specific functional outcome following primary total knee replacement","authors":"Jack Lovie,&nbsp;Nicholas D. Clement,&nbsp;Deborah MacDonald,&nbsp;Issaq Ahmed","doi":"10.1007/s00402-024-05704-9","DOIUrl":"10.1007/s00402-024-05704-9","url":null,"abstract":"<div><h3>Introduction</h3><p>The combined effect of diabetes mellitus and obesity (Diabesity) on total knee replacement (TKR) outcomes is unclear. This study aimed to assess whether diabesity influenced functional outcomes and complication rate following primary TKR.</p><h3>Materials and methods</h3><p>This case-controlled study compared the independent effects of obesity, diabetes, and diabesity on TKR outcomes. Data were collected pre-operatively and 12 months post-operatively from a single study centre. Outcomes included Oxford Knee Score (OKS), EuroQol 5-dimensions (Eq. 5D), post-operative satisfaction and complication rate.</p><h3>Results</h3><p>There were 2577 TKRs in the cohort, of which 244 (9.5%) had diabesity. Diabesity was independently associated with reduced pre-operative OKS (-1.14 points, 95% CI -1.97 to -0.31, <i>p</i> = 0.007) and OKS improvement (-2.37 points, 95% CI -3.11 to -1.62, <i>p</i> &lt; 0.001). Obesity was also independently associated with worse pre-operative OKS (-0.78 points, 95% CI -1.28 to -0.27, <i>p</i> = 0.003) and OKS improvement (-0.81 points, 95% CI -1.26 to -0.35, <i>p</i> = 0.001). Both diabesity (-0.05 points, 95% CI -0.08 to -0.02, <i>p</i> = 0.003) and obesity (-0.02 points, 95% CI -0.04 to 0.00, <i>p</i> = 0.039) were associated with worse pre-operative Eq. 5D score. Patients with diabesity reported reduced post-operative satisfaction due to obesity independently (OR 0.75, 95% CI 0.56 to 1.00, <i>p</i> = 0.048). Diabesity was not independently associated with post-operative complications.</p><h3>Conclusions</h3><p>Diabesity was independently associated with a worse knee-specific function and Eq. 5D score pre-operatively, and diminished joint specific functional improvement following TKR. Patients with diabesity also experienced reduced post-operative satisfaction due to obesity independently.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic packing – status 2024
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05699-3
Axel Gänsslen, Tim Pohlemann, Jan Lindahl, Jan Erik Madsen

Patients with unstable hemodynamics and unstable pelvic ring injuries are still demanding patients regarding initial treatment and survival. Several concepts were reported during the last 30 years. Mechanical stabilization of the pelvis together with hemorrhage control offer the best treatment option in these patients. While pelvic ring stabilization using pelvic binders, external fixators and the pelvic C-clamp are the basis for mechanical stability of the pelvic ring, the optimal modality for pelvic bleeding control is still under discussion. Beside angioembolization (AE) and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), pelvic packing PP (predominantly extraperitoneal) with direct access to the pelvic bleeding sources, are potential options. The present overview represents the present status, results and the value of pelvic packing in treating these patients. Interpretation of these results must consider the difference between the initial European concept of pelvic ring stabilization followed by PP in contrast to the North American concept with a reduced rate of pelvic ring stabilizations.

{"title":"Pelvic packing – status 2024","authors":"Axel Gänsslen,&nbsp;Tim Pohlemann,&nbsp;Jan Lindahl,&nbsp;Jan Erik Madsen","doi":"10.1007/s00402-024-05699-3","DOIUrl":"10.1007/s00402-024-05699-3","url":null,"abstract":"<div><p>Patients with unstable hemodynamics and unstable pelvic ring injuries are still demanding patients regarding initial treatment and survival. Several concepts were reported during the last 30 years. Mechanical stabilization of the pelvis together with hemorrhage control offer the best treatment option in these patients. While pelvic ring stabilization using pelvic binders, external fixators and the pelvic C-clamp are the basis for mechanical stability of the pelvic ring, the optimal modality for pelvic bleeding control is still under discussion. Beside angioembolization (AE) and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), pelvic packing PP (predominantly extraperitoneal) with direct access to the pelvic bleeding sources, are potential options. The present overview represents the present status, results and the value of pelvic packing in treating these patients. Interpretation of these results must consider the difference between the initial European concept of pelvic ring stabilization followed by PP in contrast to the North American concept with a reduced rate of pelvic ring stabilizations.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-024-05699-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential effects of tibia varus deformity on clinical outcomes following high tibial osteotomy and unicompartmental knee arthroplasty for moderate medial compartment osteoarthritis with moderate varus alignment
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05718-3
Jun-Gu Park, Seung-Beom Han, Ki-Mo Jang, Seung-Min Shin

Introduction

There is a lack of clinical evidence supporting the decision-making process between high tibial osteotomy (HTO) and unicomparmental knee arthroplasty (UKA) in gray zone indication, such as moderate medial osteoarthritis with moderate varus alignment. This study compared the outcomes between HTO and UKA in such cases and assessed the risk factor for not maintaining clinical improvements.

Materials and methods

We retrospectively reviewed 65 opening-wedge HTOs and 55 UKAs with moderate medial osteoarthritis (Kellgren-Lawrence grade ≥ 3 and Ahlback grade < 3) and moderate varus alignment (5°< Hip-Knee-Ankle angle < 10°) over 3 years follow-up. Confounding factors including patient demographics, postoperative lower limb alignment was assessed. Dummy variable was used to categorize the HTO and UKA according to presence of tibia varus deformity (medial proximal tibial angle of 85°). Clinical outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score preoperatively, 1 year postoperatively, and at the last follow-up. Cox regression analysis identified risk factors for not achieving minimal clinically important differences (MCID) in WOMAC scores.

Results

The WOMAC score at 1-postoperative year significantly improved beyond MCID in all UKA and HTO. However, over a mean follow-up of 68.7 months (HTO) and 64.3 months (UKA), 16 patients (13.3%) experienced clinical deterioration. Notably, patients with suboptimal postoperative alignment, those undergoing HTO without tibial vara, and UKA with tibial vara had higher risks of clinical deterioration during the mid-term period.

Conclusion

Tibial varus deformity differentially affects clinical outcomes after HTO and UKA in moderate medial compartment osteoarthritis with moderate varus alignment. Clinicians should consider the deformity’s origin when selecting treatment for this patient, as certain combinations (HTO without tibia vara and UKA with tibia vara) are associated with increased risk of not maintaining mid-term clinical improvements.

{"title":"Differential effects of tibia varus deformity on clinical outcomes following high tibial osteotomy and unicompartmental knee arthroplasty for moderate medial compartment osteoarthritis with moderate varus alignment","authors":"Jun-Gu Park,&nbsp;Seung-Beom Han,&nbsp;Ki-Mo Jang,&nbsp;Seung-Min Shin","doi":"10.1007/s00402-024-05718-3","DOIUrl":"10.1007/s00402-024-05718-3","url":null,"abstract":"<div><h3>Introduction</h3><p>There is a lack of clinical evidence supporting the decision-making process between high tibial osteotomy (HTO) and unicomparmental knee arthroplasty (UKA) in gray zone indication, such as moderate medial osteoarthritis with moderate varus alignment. This study compared the outcomes between HTO and UKA in such cases and assessed the risk factor for not maintaining clinical improvements.</p><h3>Materials and methods</h3><p>We retrospectively reviewed 65 opening-wedge HTOs and 55 UKAs with moderate medial osteoarthritis (Kellgren-Lawrence grade ≥ 3 and Ahlback grade &lt; 3) and moderate varus alignment (5°&lt; Hip-Knee-Ankle angle &lt; 10°) over 3 years follow-up. Confounding factors including patient demographics, postoperative lower limb alignment was assessed. Dummy variable was used to categorize the HTO and UKA according to presence of tibia varus deformity (medial proximal tibial angle of 85°). Clinical outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score preoperatively, 1 year postoperatively, and at the last follow-up. Cox regression analysis identified risk factors for not achieving minimal clinically important differences (MCID) in WOMAC scores.</p><h3>Results</h3><p>The WOMAC score at 1-postoperative year significantly improved beyond MCID in all UKA and HTO. However, over a mean follow-up of 68.7 months (HTO) and 64.3 months (UKA), 16 patients (13.3%) experienced clinical deterioration. Notably, patients with suboptimal postoperative alignment, those undergoing HTO without tibial vara, and UKA with tibial vara had higher risks of clinical deterioration during the mid-term period.</p><h3>Conclusion</h3><p>Tibial varus deformity differentially affects clinical outcomes after HTO and UKA in moderate medial compartment osteoarthritis with moderate varus alignment. Clinicians should consider the deformity’s origin when selecting treatment for this patient, as certain combinations (HTO without tibia vara and UKA with tibia vara) are associated with increased risk of not maintaining mid-term clinical improvements.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: a systematic review
IF 2 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-11 DOI: 10.1007/s00402-024-05711-w
Maria Anna Smolle, Markus G. Seidel, Karl Kashofer, Bernadette Liegl-Atzwanger, Patrick Sadoghi, Daniel A. Müller, Andreas Leithner

Introduction

Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms.

Materials and methods

A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas.

Results

Overall, data on clinical applicability of liquid biopsy in 2636 patients with > 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively.

Conclusions

This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.

{"title":"Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: a systematic review","authors":"Maria Anna Smolle,&nbsp;Markus G. Seidel,&nbsp;Karl Kashofer,&nbsp;Bernadette Liegl-Atzwanger,&nbsp;Patrick Sadoghi,&nbsp;Daniel A. Müller,&nbsp;Andreas Leithner","doi":"10.1007/s00402-024-05711-w","DOIUrl":"10.1007/s00402-024-05711-w","url":null,"abstract":"<div><h3>Introduction</h3><p>Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms.</p><h3>Materials and methods</h3><p>A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas.</p><h3>Results</h3><p>Overall, data on clinical applicability of liquid biopsy in 2636 patients with &gt; 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively.</p><h3>Conclusions</h3><p>This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-024-05711-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of Orthopaedic and Trauma Surgery
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1