Pub Date : 2025-06-24DOI: 10.1016/j.oftal.2025.05.001
D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano
A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.
{"title":"Enfermedad de Stargardt por mutación en ABCA4 en un adulto joven: reporte de caso y alternativas actuales de tratamientos ópticos y médicos","authors":"D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano","doi":"10.1016/j.oftal.2025.05.001","DOIUrl":"10.1016/j.oftal.2025.05.001","url":null,"abstract":"<div><div>A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 571-575"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-17DOI: 10.1016/j.oftal.2025.04.005
Javier Garulo Nicolás , Laura Manfreda Domínguez , Patricia Bayo Calduch , Sergio Obiol Ferrando , Andrea Català Nadal , Antonio Miguel Duch Samper
Papillary drusen are deposits of calcified hyaline material at the level of the optic nerve head. They are considered the most frequent cause of pseudopapilledema, so in clinical practice it is essential to identify and differentiate them from true optic disc oedema.
Parainfectious optic neuritis is an inflammatory optic neuropathy, usually bilateral and acute, which occurs between 1 and 3 weeks after an infectious disease. It usually occurs as a papillitis, since it is usually located in the head of the optic nerve causing optic disc oedema.
In this article we present an unusual case of bilateral papillitis superimposed on papillary drusen in a young male with Chlamydia trachomatis prostatitis. After an exhaustive etiological study, it was concluded that, in this patie
nt, papillitis was associated with his sexually transmitted disease.
{"title":"Papilitis parainfecciosa bilateral superpuesta a seudoedema de papila por drusas del nervio óptico","authors":"Javier Garulo Nicolás , Laura Manfreda Domínguez , Patricia Bayo Calduch , Sergio Obiol Ferrando , Andrea Català Nadal , Antonio Miguel Duch Samper","doi":"10.1016/j.oftal.2025.04.005","DOIUrl":"10.1016/j.oftal.2025.04.005","url":null,"abstract":"<div><div>Papillary drusen are deposits of calcified hyaline material at the level of the optic nerve head. They are considered the most frequent cause of pseudopapilledema, so in clinical practice it is essential to identify and differentiate them from true optic disc oedema.</div><div>Parainfectious optic neuritis is an inflammatory optic neuropathy, usually bilateral and acute, which occurs between 1 and 3 weeks after an infectious disease. It usually occurs as a papillitis, since it is usually located in the head of the optic nerve causing optic disc oedema.</div><div>In this article we present an unusual case of bilateral papillitis superimposed on papillary drusen in a young male with Chlamydia trachomatis prostatitis. After an exhaustive etiological study, it was concluded that, in this patie</div><div>nt, papillitis was associated with his sexually transmitted disease.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 558-562"},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-10DOI: 10.1016/j.oftal.2024.12.009
P.L. Matilde Mora , J. Tirado-Ángel , M.A. Martínez-Ceballos
Bacterial keratitis is one of the leading causes of monocular blindness worldwide. The following case describes the case of a patient with bilateral bacterial keratitis caused by Klebsiella oxytoca, a gram-negative bacterium often overlooked in cases of bacterial infectious keratitis. The patient is a 20-year-old man with a past medical history of allergic keratoconjunctivitis and keratoconus who developed an epithelial defect following improper handling of his contact lenses. Initially, the patient was managed with ocular lubricants. However, he experienced a rapid and aggressive deterioration in visual acuity, with an expansion of the epithelial defect and the appearance of bilateral stromal infiltrates. Due to the poor response to empirical antimicrobial therapy, cultures were obtained from the contact lenses, which identified the presence of K. oxytoca as the causative agent. The antibiogram revealed resistance to widely used antibiotics such as ciprofloxacin. Following these results, targeted antimicrobial therapy was initiated, leading to significant clinical improvement and substantial anatomical and visual recovery. This case underscores the importance of recognizing the potential aggressiveness of K. oxytoca in immunocompetent patients, which can cause severe ocular infections, particularly in individuals with risk factors such as contact lens wear. It also highlights the critical need for microbiological cultures and antibiograms to guide effective therapy, given the variable resistance patterns of this microorganism.
{"title":"Úlcera corneal bilateral por K. oxytoca: reporte de un caso","authors":"P.L. Matilde Mora , J. Tirado-Ángel , M.A. Martínez-Ceballos","doi":"10.1016/j.oftal.2024.12.009","DOIUrl":"10.1016/j.oftal.2024.12.009","url":null,"abstract":"<div><div>Bacterial keratitis is one of the leading causes of monocular blindness worldwide. The following case describes the case of a patient with bilateral bacterial keratitis caused by <em>Klebsiella oxytoca</em>, a gram-negative bacterium often overlooked in cases of bacterial infectious keratitis. The patient is a 20-year-old man with a past medical history of allergic keratoconjunctivitis and keratoconus who developed an epithelial defect following improper handling of his contact lenses. Initially, the patient was managed with ocular lubricants. However, he experienced a rapid and aggressive deterioration in visual acuity, with an expansion of the epithelial defect and the appearance of bilateral stromal infiltrates. Due to the poor response to empirical antimicrobial therapy, cultures were obtained from the contact lenses, which identified the presence of <em>K. oxytoca</em> as the causative agent. The antibiogram revealed resistance to widely used antibiotics such as ciprofloxacin. Following these results, targeted antimicrobial therapy was initiated, leading to significant clinical improvement and substantial anatomical and visual recovery. This case underscores the importance of recognizing the potential aggressiveness of <em>K. oxytoca</em> in immunocompetent patients, which can cause severe ocular infections, particularly in individuals with risk factors such as contact lens wear. It also highlights the critical need for microbiological cultures and antibiograms to guide effective therapy, given the variable resistance patterns of this microorganism.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 563-570"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.02.003
R. Navarro , E. Ballesteros-Zamalloa , R. Hualpa-Vicente , P. Minami , M.A. Rodríguez-Cuba
Objective
To describe the microbiological profile of bacterial and fungal corneal ulcers, as well as the antibiotic susceptibility profile of the most frequent pathogenic species.
Methods
A retrospective descriptive study was conducted using the recorded data of corneal ulcer scrapings from the ocular microbiology laboratory of the National Institute of Ophthalmology. Laboratory data from 2015 to 2022 were collected and included for all corneal ulcer scrapings.
Results
After excluding repeated, non-cultured, and duplicate results, a total of 3,470 corneal samples were analyzed. Positive samples accounted for 88,1% of all scraps. Of these, 2,816 (81,2%), 904 (26,2%), and 662 (19,1%) showed bacterial, fungal, and mixed growth, respectively, coagulase-negative Staphylococci (2,257; 69,8%) were the most frequent bacteria, with Staphylococcusepidermidis (1,677; 51,9%) being the most isolated organism, followed by Pseudomonasaeruginosa (275; 8,5%) and Staphylococcusaureus (274; 8,5%). Fusarium spp, was the most common fungus. Less than 60% of S. epidermidis isolates showed susceptibility to oxacillin, cefazolin, moxifloxacin, and gentamicin, while more than 90% of isolates were susceptible to gatifloxacin. P. aeruginosa showed less than 80% susceptibility only to imipenem.
Conclusion
Gram-positive bacteria were the most isolated, with S. epidermidis being the most frequent pathogen, followed by P. aeruginosa. S. epidermidis exhibited alarmingly low susceptibility to commonly used antibiotics.
{"title":"Perfil microbiológico de úlceras corneales bacterianas y fúngicas en un instituto nacional de oftalmología en Perú","authors":"R. Navarro , E. Ballesteros-Zamalloa , R. Hualpa-Vicente , P. Minami , M.A. Rodríguez-Cuba","doi":"10.1016/j.oftal.2025.02.003","DOIUrl":"10.1016/j.oftal.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the microbiological profile of bacterial and fungal corneal ulcers, as well as the antibiotic susceptibility profile of the most frequent pathogenic species.</div></div><div><h3>Methods</h3><div>A retrospective descriptive study was conducted using the recorded data of corneal ulcer scrapings from the ocular microbiology laboratory of the National Institute of Ophthalmology. Laboratory data from 2015 to 2022 were collected and included for all corneal ulcer scrapings.</div></div><div><h3>Results</h3><div>After excluding repeated, non-cultured, and duplicate results, a total of 3,470 corneal samples were analyzed. Positive samples accounted for 88,1% of all scraps. Of these, 2,816 (81,2%), 904 (26,2%), and 662 (19,1%) showed bacterial, fungal, and mixed growth, respectively, coagulase-negative <em>Staphylococci</em> (2,257; 69,8%) were the most frequent bacteria, with <em>Staphylococcus</em> <em>epidermidis</em> (1,677; 51,9%) being the most isolated organism, followed by <em>Pseudomonas</em> <em>aeruginosa</em> (275; 8,5%) and <em>Staphylococcus</em> <em>aureus</em> (274; 8,5%). <em>Fusarium</em> spp, was the most common fungus. Less than 60% of <em>S</em>. <em>epidermidis</em> isolates showed susceptibility to oxacillin, cefazolin, moxifloxacin, and gentamicin, while more than 90% of isolates were susceptible to gatifloxacin. <em>P</em>. <em>aeruginosa</em> showed less than 80% susceptibility only to imipenem.</div></div><div><h3>Conclusion</h3><div>Gram-positive bacteria were the most isolated, with <em>S</em>. <em>epidermidis</em> being the most frequent pathogen, followed by <em>P</em>. <em>aeruginosa</em>. <em>S</em>. <em>epidermidis</em> exhibited alarmingly low susceptibility to commonly used antibiotics.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 306-313"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2024.12.008
J. González-Martín-Moro , N. Ventura-Abreu , J. Zarallo-Gallardo , F.J. Muñoz-Negrete
Purpose
To assess the perception and knowledge Spanish ophthalmologists have of overdiagnosis (OD) and overtreatment (OT) in the field of glaucoma.
Methods
An anonymous, 26-item online survey was submitted to members of the Spanish Glaucoma Society and the Spanish Ophthalmology Society.
Results
A total of 55% out of the 195 respondents were aware of the current definition of OD/OT. Only 13 (6.7%) believe OD/OT is not a clinically significant problem. There were no significant differences in terms of demographics, type of practice and treatment preferences between ophthalmologists who considered OD/OT important and those who considerd OD/OT unimportant, except for a higher proportion of PhDs among the “not clinically relevant” group. No differences were found either across groups considering clinical findings/real-world scenarios. “Peace of mind” was considered a principal driver of OD/OT by both groups. Moderate OHT was considered the most common clinical scenario for OD/OT, which was estimated to affect 20% of medically treated patients and only 5% of those undergoing surgical procedures.
Conclusions
Spanish ophthalmologists reported being aware of the importance of OD and OT. However, only half were aware of the current definition of OD and OT. Most participants believe a White Paper should be produced to reduce the prevalence of OD/OT. The low participation rate and the non-response bias may limit the generalization of the results.
{"title":"Encuesta sobre la percepción que los oftalmólogos españoles tienen del sobrediagnóstico y sobretratamiento en glaucoma","authors":"J. González-Martín-Moro , N. Ventura-Abreu , J. Zarallo-Gallardo , F.J. Muñoz-Negrete","doi":"10.1016/j.oftal.2024.12.008","DOIUrl":"10.1016/j.oftal.2024.12.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the perception and knowledge Spanish ophthalmologists have of overdiagnosis (OD) and overtreatment (OT) in the field of glaucoma.</div></div><div><h3>Methods</h3><div>An anonymous, 26-item online survey was submitted to members of the Spanish Glaucoma Society and the Spanish Ophthalmology Society.</div></div><div><h3>Results</h3><div>A total of 55% out of the 195 respondents were aware of the current definition of OD/OT. Only 13 (6.7%) believe OD/OT is not a clinically significant problem. There were no significant differences in terms of demographics, type of practice and treatment preferences between ophthalmologists who considered OD/OT important and those who considerd OD/OT unimportant, except for a higher proportion of PhDs among the “not clinically relevant” group. No differences were found either across groups considering clinical findings/real-world scenarios. “Peace of mind” was considered a principal driver of OD/OT by both groups. Moderate OHT was considered the most common clinical scenario for OD/OT, which was estimated to affect 20% of medically treated patients and only 5% of those undergoing surgical procedures.</div></div><div><h3>Conclusions</h3><div>Spanish ophthalmologists reported being aware of the importance of OD and OT. However, only half were aware of the current definition of OD and OT. Most participants believe a White Paper should be produced to reduce the prevalence of OD/OT. The low participation rate and the non-response bias may limit the generalization of the results.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 320-329"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.02.005
C.E. Monera Lucas , C. Mora Caballero , J. Escolano Serrano , A. Machan , G. Castilla Martínez , D. Romero Valero , J. Campello Lluch
Purpose
To evaluate the performance of ChatGPT in solving clinical scenarios in ophthalmology, specifically questions from the specialty exams for Resident Medical Interns (MIR).
Design
Cross-sectional design for evaluating a diagnostic tool.
Method
Ophthalmology questions from the MIR exams from the 2010-2023 sessions were collected. The performance of ChatGPT in successfully answering the questions was calculated. The results were also compared with those obtained by ophthalmology professionals. Additionally, sensitivity, specificity, and positive and negative probability coefficients were calculated.
Results
A total of 54 questions were collected, with those from the subspecialty “Retina” being the most frequent. ChatGPT's overall score was 90.2%, with a sensitivity of 92.59% and a specificity of 96.8%. The average concordance with the evaluators’ answers was 86.41%. The agreement between the evaluators was 79.62%.
Conclusions
ChatGPT-4 is a useful tool for solving clinical scenarios and theoretical questions in ophthalmology. Proper use of the tool, supervised by professionals, can help optimize the care processes for ophthalmology patients.
{"title":"Análisis del rendimiento de ChatGPT-4 en las preguntas de oftalmología del examen MIR","authors":"C.E. Monera Lucas , C. Mora Caballero , J. Escolano Serrano , A. Machan , G. Castilla Martínez , D. Romero Valero , J. Campello Lluch","doi":"10.1016/j.oftal.2025.02.005","DOIUrl":"10.1016/j.oftal.2025.02.005","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the performance of ChatGPT in solving clinical scenarios in ophthalmology, specifically questions from the specialty exams for Resident Medical Interns (MIR).</div></div><div><h3>Design</h3><div>Cross-sectional design for evaluating a diagnostic tool.</div></div><div><h3>Method</h3><div>Ophthalmology questions from the MIR exams from the 2010-2023 sessions were collected. The performance of ChatGPT in successfully answering the questions was calculated. The results were also compared with those obtained by ophthalmology professionals. Additionally, sensitivity, specificity, and positive and negative probability coefficients were calculated.</div></div><div><h3>Results</h3><div>A total of 54 questions were collected, with those from the subspecialty “Retina” being the most frequent. ChatGPT's overall score was 90.2%, with a sensitivity of 92.59% and a specificity of 96.8%. The average concordance with the evaluators’ answers was 86.41%. The agreement between the evaluators was 79.62%.</div></div><div><h3>Conclusions</h3><div>ChatGPT-4 is a useful tool for solving clinical scenarios and theoretical questions in ophthalmology. Proper use of the tool, supervised by professionals, can help optimize the care processes for ophthalmology patients.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 314-319"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.01.002
M.M. Valentín-Pastrana Aguilar, B. Sandoval Cortés, S. Durán Poveda, L. Guerrero Altares, B. García Sandoval
Hypotony maculopathy is a potential complication of glaucoma filtering surgery, clinically relevant as it can cause vision loss. Classically, it produces choroidal folds, vascular tortuosity, and optic disc edema. However, in optical coherence tomography (OCT), it may also present as intraretinal cysts (IRC). We present the case of a patient who, 10 years after undergoing glaucoma surgery, developed ocular hypotony, IRC, and decreased visual acuity (VA). Given the patient's history of diabetes mellitus, it was initially diagnosed as diabetic macular edema (DME), which delayed appropriate treatment. This led to worsening corneal decompensation, ultimately requiring a corneal transplant in the form of Descemet membrane endothelial keratoplasty (DMEK).
{"title":"Maculopatía por hipotonía: un reto diagnóstico","authors":"M.M. Valentín-Pastrana Aguilar, B. Sandoval Cortés, S. Durán Poveda, L. Guerrero Altares, B. García Sandoval","doi":"10.1016/j.oftal.2025.01.002","DOIUrl":"10.1016/j.oftal.2025.01.002","url":null,"abstract":"<div><div>Hypotony maculopathy is a potential complication of glaucoma filtering surgery, clinically relevant as it can cause vision loss. Classically, it produces choroidal folds, vascular tortuosity, and optic disc edema. However, in optical coherence tomography (OCT), it may also present as intraretinal cysts (IRC). We present the case of a patient who, 10<!--> <!-->years after undergoing glaucoma surgery, developed ocular hypotony, IRC, and decreased visual acuity (VA). Given the patient's history of diabetes mellitus, it was initially diagnosed as diabetic macular edema (DME), which delayed appropriate treatment. This led to worsening corneal decompensation, ultimately requiring a corneal transplant in the form of Descemet membrane endothelial keratoplasty (DMEK).</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 351-355"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.01.009
A. Matheu Fabra , J.E. Martínez Rodríguez , B. Beltrán Mármol , M. Saint-Gerons Trecu
Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating autoimmune disease that affects the optic nerves, spinal cord and brain stem. It generally affects women between 30 and 40 years of age and has as a marker the anti-aquaporin-4 (AQP4) antibody.
We describe two Caucasian patients, a woman and a man aged 72 and 76 years, respectively, who presented with optic neuritis as the initial manifestation of NMOSD, with positive AQP4 antibodies.
Very late-onset NMOSD (over 70 years of age) is very rare and, according to small published series, in these patients, generally non-Caucasian, spinal cord involvement predominates and they have a worse prognosis. We consider that our cases illustrate the importance of including this entity in the differential diagnosis of atypical optic neuropathies even in advanced age, given the severity of this disease, which requires early and aggressive treatment.
{"title":"Neuromielitis óptica de inicio muy tardío, a propósito de dos casos","authors":"A. Matheu Fabra , J.E. Martínez Rodríguez , B. Beltrán Mármol , M. Saint-Gerons Trecu","doi":"10.1016/j.oftal.2025.01.009","DOIUrl":"10.1016/j.oftal.2025.01.009","url":null,"abstract":"<div><div>Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating autoimmune disease that affects the optic nerves, spinal cord and brain stem. It generally affects women between 30 and 40 years of age and has as a marker the anti-aquaporin-4 (AQP4) antibody.</div><div>We describe two Caucasian patients, a woman and a man aged 72 and 76 years, respectively, who presented with optic neuritis as the initial manifestation of NMOSD, with positive AQP4 antibodies.</div><div>Very late-onset NMOSD (over 70 years of age) is very rare and, according to small published series, in these patients, generally non-Caucasian, spinal cord involvement predominates and they have a worse prognosis. We consider that our cases illustrate the importance of including this entity in the differential diagnosis of atypical optic neuropathies even in advanced age, given the severity of this disease, which requires early and aggressive treatment.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 367-371"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.02.004
E. Garcia-Martin , J. Pérez-Velilla , B. Cordon , E. Vilades , M.J. Rodrigo , L.E. Pablo
{"title":"Actualización de la utilidad de la angiografía mediada por tomografía de coherencia óptica en las enfermedades neurodegenerativas","authors":"E. Garcia-Martin , J. Pérez-Velilla , B. Cordon , E. Vilades , M.J. Rodrigo , L.E. Pablo","doi":"10.1016/j.oftal.2025.02.004","DOIUrl":"10.1016/j.oftal.2025.02.004","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 303-305"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.oftal.2025.02.009
K. Camargo-Parra , F.J. Bonilla-Escobar , E. Lozano-Cruz , O. Salamanca , A. Martínez-Blanco , A.F. Plaza-Hernández
Background and objective
Glaucoma, a leading cause of preventable blindness, significantly impacts patients’ quality of life (QoL). The GQL-15 (1999) assesses functional disability due to glaucoma through 15 items across 4 domains. However, it has not been validated in Spanish. This study aimed to validate and update the GQL-15 for Spanish-speaking individuals.
Methods
We conducted a cross-sectional study with individuals diagnosed with glaucoma at 2 ophthalmological referral centers in Cali-Colombia. Researchers translated the GQL-15 into Spanish and modified it by replacing the ‘reading newspaper’ item with ‘reading on a cellphone/mobile/smartphone’ to modernize the questionnaire (GQL-15m). The GQL-15m was tested for validity and reliability using Cronbach's alpha (α) coefficient, exploratory factor analysis, and criterion validity. Reproducibility was assessed through a 2-week test-retest analysis.
Results
A total of 157 out of 468 eligible patients with glaucoma participated in the survey (33% response rate). The mean age was 67 ± 12 years (64%, women). The GQL-15m showed a mean total score of 29.3 ± 7.31, suggesting good QoL. Internal consistency was high for both the GQL-15 (α = 0.97) and GQL-15m (α = 0.96). Criterion validity was supported by significant correlations between the GQL-15m scores and the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ 25), World Health Organization Quality of Life-BREF (WHOQoL-BREF), Glaucoma Symptom Scale (GSS), Glaucoma Utility Index (GUI), and visual acuity. Reproducibility was high, with an intraclass correlation coefficient (ICC) of 0.89.
Conclusions
The GQL-15m is a reliable and valid instrument for assessing QoL in Spanish-speaking individuals with glaucoma and has potential for broader application across various cultural contexts.
{"title":"Validación y actualización del cuestionario de calidad de vida en glaucoma (GQL-15) para individuos de habla hispana","authors":"K. Camargo-Parra , F.J. Bonilla-Escobar , E. Lozano-Cruz , O. Salamanca , A. Martínez-Blanco , A.F. Plaza-Hernández","doi":"10.1016/j.oftal.2025.02.009","DOIUrl":"10.1016/j.oftal.2025.02.009","url":null,"abstract":"<div><h3>Background and objective</h3><div>Glaucoma, a leading cause of preventable blindness, significantly impacts patients’ quality of life (QoL). The GQL-15 (1999) assesses functional disability due to glaucoma through 15 items across 4 domains. However, it has not been validated in Spanish. This study aimed to validate and update the GQL-15 for Spanish-speaking individuals.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study with individuals diagnosed with glaucoma at 2 ophthalmological referral centers in Cali-Colombia. Researchers translated the GQL-15 into Spanish and modified it by replacing the ‘reading newspaper’ item with ‘reading on a cellphone/mobile/smartphone’ to modernize the questionnaire (GQL-15m). The GQL-15m was tested for validity and reliability using Cronbach's alpha (α) coefficient, exploratory factor analysis, and criterion validity. Reproducibility was assessed through a 2-week test-retest analysis.</div></div><div><h3>Results</h3><div>A total of 157 out of 468 eligible patients with glaucoma participated in the survey (33% response rate). The mean age was 67<!--> <!-->±<!--> <!-->12 years (64%, women). The GQL-15m showed a mean total score of 29.3<!--> <!-->±<!--> <!-->7.31, suggesting good QoL. Internal consistency was high for both the GQL-15 (α<!--> <!-->=<!--> <!-->0.97) and GQL-15m (α<!--> <!-->=<!--> <!-->0.96). Criterion validity was supported by significant correlations between the GQL-15m scores and the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ 25), World Health Organization Quality of Life-BREF (WHOQoL-BREF), Glaucoma Symptom Scale (GSS), Glaucoma Utility Index (GUI), and visual acuity. Reproducibility was high, with an intraclass correlation coefficient (ICC) of 0.89.</div></div><div><h3>Conclusions</h3><div>The GQL-15m is a reliable and valid instrument for assessing QoL in Spanish-speaking individuals with glaucoma and has potential for broader application across various cultural contexts.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 6","pages":"Pages 330-339"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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