Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2024.11.012
N. Laaribi, R. Mendes, K. Reda, A. Oubaaz
Corneal crosslinking is considered a safe procedure even if sight-threatening side effects have been reported. Other han our case report, few reports of herpetic keratitis (HK) after crosslinking have been published. We report a new onset HK after corneal crosslinking for keratoconus.
A 40-year-old woman underwent corneal collagen crosslinking in her right eye for progressive keratoconus. The patient returned with pain and photophobia. Infiltration in the corneal stroma was observed. Fluorescein staining specified epithelial defects overlying the corneal infiltrates.
The diagnostic of HK was confirmed with polymerase chain reaction for DNA detection of HSV type 1 of corneal swab. The epithelial defect healed with oral valacyclovir treatment.
Topical corticosteroid drops and preservative-free lubricant eye drops were, also, added to the antiviral treatment. Afterwards, a decrease in stromal infiltrate was observed.
This case report highlights the risk of HK after crosslinking and elucidates the importance of timely diagnosis of this unusual but important complication. The ophthalmologist should be aware of the possibility of HK in eyes after crosslinking, even in patients without a past medical history of HSV infection.
{"title":"Queratitis herpética después de crosslinkig corneal","authors":"N. Laaribi, R. Mendes, K. Reda, A. Oubaaz","doi":"10.1016/j.oftal.2024.11.012","DOIUrl":"10.1016/j.oftal.2024.11.012","url":null,"abstract":"<div><div>Corneal crosslinking is considered a safe procedure even if sight-threatening side effects have been reported. Other han our case report, few reports of herpetic keratitis (HK) after crosslinking have been published. We report a new onset HK after corneal crosslinking for keratoconus.</div><div>A 40-year-old woman underwent corneal collagen crosslinking in her right eye for progressive keratoconus. The patient returned with pain and photophobia. Infiltration in the corneal stroma was observed. Fluorescein staining specified epithelial defects overlying the corneal infiltrates.</div><div>The diagnostic of HK was confirmed with polymerase chain reaction for DNA detection of HSV type 1 of corneal swab. The epithelial defect healed with oral valacyclovir treatment.</div><div>Topical corticosteroid drops and preservative-free lubricant eye drops were, also, added to the antiviral treatment. Afterwards, a decrease in stromal infiltrate was observed.</div><div>This case report highlights the risk of HK after crosslinking and elucidates the importance of timely diagnosis of this unusual but important complication. The ophthalmologist should be aware of the possibility of HK in eyes after crosslinking, even in patients without a past medical history of <em>HSV</em> infection.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 435-438"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2025.01.005
M. Sanchidrián Mayo
{"title":"Grabaciones con teléfonos móviles en consulta de oftalmología: límites legales","authors":"M. Sanchidrián Mayo","doi":"10.1016/j.oftal.2025.01.005","DOIUrl":"10.1016/j.oftal.2025.01.005","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 375-376"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2025.01.010
L.M. Méndez-Rodríguez , L.C. Nocua-Báez , G. Mejía-Salgado , A. de-la-Torre , C.A. Álvarez-Moreno
Infectious uveitis is an inflammation of the uveal tract, corresponding to the eye's middle layer, triggered by a response against an infectious agent. This condition is classified into anterior, intermediate, posterior and panuveitis. The most frequent infectious agents in anterior uveitis are viruses, mainly herpes simplex virus. However, it can also be caused by other pathogens such as Bartonella spp., Mycobacterium tuberculosis and Fusarium spp. In intermediate uveitis, syphilis plays a predominant role, while in posterior uveitis various microorganisms are involved, among them Toxoplasma gondii, Cytomegalovirus, Plasmodium spp. and Candida spp. In some instances, as in ocular toxoplasmosis, severe inflammation may involve the entire uvea, resulting in panuveitis.
Clinical manifestations of uveitis include ocular pain, redness, myodesopsias, blurred vision, and even vision loss. Direct identification of the causative agent is complex, and the diagnostic performance of available tests varies significantly. For example, polymerase chain reaction (PCR) on ocular specimens for Herpes simplex virus has a sensitivity of 91.3% and specificity of 98.8%, while for toxoplasmosis the sensitivity is 43.1% and specificity 98.5%. Another challenge in infectious uveitis is treatment, as systemic antimicrobials generally have a low penetration into ocular tissue, mostly less than 5%, mainly due to the blood-retinal and blood-aqueous barriers. The efficacy of the molecules in ocular tissue is favored by low protein binding and high liposolubility.
This review addresses the most frequent clinical manifestations of bacterial, viral, parasitic and fungal etiologies of infectious uveitis, as well as the diagnostic performance of available tests. In addition, emphasis is placed on the different therapeutic approaches depending on etiology.
{"title":"Uveítis infecciosa: epidemiología, etiología, rendimiento de pruebas diagnósticas y tratamiento","authors":"L.M. Méndez-Rodríguez , L.C. Nocua-Báez , G. Mejía-Salgado , A. de-la-Torre , C.A. Álvarez-Moreno","doi":"10.1016/j.oftal.2025.01.010","DOIUrl":"10.1016/j.oftal.2025.01.010","url":null,"abstract":"<div><div>Infectious uveitis is an inflammation of the uveal tract, corresponding to the eye's middle layer, triggered by a response against an infectious agent. This condition is classified into anterior, intermediate, posterior and panuveitis. The most frequent infectious agents in anterior uveitis are viruses, mainly herpes simplex virus. However, it can also be caused by other pathogens such as <em>Bartonella</em> spp<em>., Mycobacterium tuberculosis</em> and <em>Fusarium</em> spp<em>.</em> In intermediate uveitis, syphilis plays a predominant role, while in posterior uveitis various microorganisms are involved, among them <em>Toxoplasma gondii, Cytomegalovirus, Plasmodium</em> spp<em>. and Candida</em> spp. In some instances, as in ocular toxoplasmosis, severe inflammation may involve the entire uvea, resulting in panuveitis.</div><div>Clinical manifestations of uveitis include ocular pain, redness, myodesopsias, blurred vision, and even vision loss. Direct identification of the causative agent is complex, and the diagnostic performance of available tests varies significantly. For example, polymerase chain reaction (PCR) on ocular specimens for Herpes simplex virus has a sensitivity of 91.3% and specificity of 98.8%, while for toxoplasmosis the sensitivity is 43.1% and specificity 98.5%. Another challenge in infectious uveitis is treatment, as systemic antimicrobials generally have a low penetration into ocular tissue, mostly less than 5%, mainly due to the blood-retinal and blood-aqueous barriers. The efficacy of the molecules in ocular tissue is favored by low protein binding and high liposolubility.</div><div>This review addresses the most frequent clinical manifestations of bacterial, viral, parasitic and fungal etiologies of infectious uveitis, as well as the diagnostic performance of available tests. In addition, emphasis is placed on the different therapeutic approaches depending on etiology.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 397-420"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2024.11.011
Manuel Gonzalez de la Rosa, Marta Gonzalez Hernandez, Daniel Gonzalez-Hernandez
The relationship between the optic disc area and the vertical cup/disc ratio is presented by means of a graphic nomogram after studying a total of 365,356 normal optic nerves. For this purpose, the Laguna ONhE application was used, which analyses the distribution of hemoglobin based on the colorimetric analysis of fundus color images. The 1%, 5%, 50% and 95% percentiles are given for disc areas between 1 mm2 and 4 mm2. The highest cup-to-disc ratios (1-5% percentiles) were close to 0.7 for large discs, while for more common sizes (1.9-2.0 mm2) they were close to 0.6 and for small ones to 0.5. Data allowed the Laguna ONhE Globin Discriminant Function (GDF) index to be corrected, in such a way that it could, then, be verified in 544 normal eyes that it was less dependent on the vertical cup/disc ratio, whereas in 436 confirmed and suspected glaucoma an intimate relationship was reported.
{"title":"Frecuencia del cociente vertical copa-disco con relación al tamaño del disco óptico normal","authors":"Manuel Gonzalez de la Rosa, Marta Gonzalez Hernandez, Daniel Gonzalez-Hernandez","doi":"10.1016/j.oftal.2024.11.011","DOIUrl":"10.1016/j.oftal.2024.11.011","url":null,"abstract":"<div><div>The relationship between the optic disc area and the vertical cup/disc ratio is presented by means of a graphic nomogram after studying a total of 365,356 normal optic nerves. For this purpose, the Laguna ONhE application was used, which analyses the distribution of hemoglobin based on the colorimetric analysis of fundus color images. The 1%, 5%, 50% and 95% percentiles are given for disc areas between 1<!--> <!-->mm<sup>2</sup> and 4<!--> <!-->mm<sup>2</sup>. The highest cup-to-disc ratios (1-5% percentiles) were close to 0.7 for large discs, while for more common sizes (1.9-2.0<!--> <!-->mm<sup>2</sup>) they were close to 0.6 and for small ones to 0.5. Data allowed the Laguna ONhE Globin Discriminant Function (GDF) index to be corrected, in such a way that it could, then, be verified in 544 normal eyes that it was less dependent on the vertical cup/disc ratio, whereas in 436 confirmed and suspected glaucoma an intimate relationship was reported.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 431-434"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2025.02.008
Ó. García-Espinilla , P. Arlanzón-Lope , A. Novo-Díez , D.R. Llanos Ferraris , S. Ortiz-Toquero , P. de la Iglesia Rodríguez , M. López-Gálvez , J.C. Pastor
Background and objectives
Diabetic retinopathy (DR) is the most common ocular complication of diabetes. Screening programmes using fundus examination with retinal imaging are a useful tool for early diagnosis of DR and an improved disease prognosis. The purpose of this study is to analyse the number of patients attended in the DR screening programme of the Castilla y León health system and to estimate DR prevalence and severity.
Material and methods
An observational study of patients previously registered as diabetic who participated in the screening programme between 2018 and 2028 was conducted. Patients were classified according to their diagnosis in non-evaluable test, non-evaluable patient, no DR, DR (mild, moderate, severe, proliferative, and suspected diabetic macular oedema) and other pathologies.
Results
The total number of consultations in the program up to the present date has been 31,901, increasing from 3,934 in 2018 to 9,508 in 2023. The estimated prevalence of DR is 15.41%. 1.58% of patients were referred to their reference hospitals due to DR or other pathologies requiring urgent treatment. The remaining patients were managed by the program.
Conclusions
The prevalence of DR appears to be slightly lower than that reported in other published series, but no significant differences were observed between different program years, overall assessment, or different forms of DR or suspected diabetic macular oedema.
背景与目的糖尿病视网膜病变（DR）是糖尿病最常见的眼部并发症。使用眼底检查和视网膜成像的筛查方案是早期诊断DR和改善疾病预后的有用工具。本研究的目的是分析Castilla y León卫生系统中参加DR筛查计划的患者人数，并估计DR的患病率和严重程度。材料和方法对2018年至2028年间参加筛查计划的既往登记为糖尿病患者进行了一项观察性研究。根据诊断结果分为不可评价试验、不可评价患者、无DR、DR（轻度、中度、重度、增殖性及疑似糖尿病性黄斑水肿）及其他病理。结果截至目前，该方案的总咨询次数为31901次，从2018年的3934次增加到2023年的9508次。DR的估计患病率为15.41%。1.58%的患者因DR或其他病理需要紧急治疗而转诊到参考医院。其余患者由该项目管理。结论：DR的患病率似乎略低于其他已发表的系列报道，但在不同的项目年限、总体评估、不同形式的DR或疑似糖尿病性黄斑水肿之间没有观察到显著差异。
{"title":"Análisis de la prevalencia de la retinopatía diabética en un programa de cribado por telemedicina durante el periodo 2018 a 2023","authors":"Ó. García-Espinilla , P. Arlanzón-Lope , A. Novo-Díez , D.R. Llanos Ferraris , S. Ortiz-Toquero , P. de la Iglesia Rodríguez , M. López-Gálvez , J.C. Pastor","doi":"10.1016/j.oftal.2025.02.008","DOIUrl":"10.1016/j.oftal.2025.02.008","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Diabetic retinopathy (DR) is the most common ocular complication of diabetes. Screening programmes using fundus examination with retinal imaging are a useful tool for early diagnosis of DR and an improved disease prognosis. The purpose of this study is to analyse the number of patients attended in the DR screening programme of the Castilla y León health system and to estimate DR prevalence and severity.</div></div><div><h3>Material and methods</h3><div>An observational study of patients previously registered as diabetic who participated in the screening programme between 2018 and 2028 was conducted. Patients were classified according to their diagnosis in non-evaluable test, non-evaluable patient, no DR, DR (mild, moderate, severe, proliferative, and suspected diabetic macular oedema) and other pathologies.</div></div><div><h3>Results</h3><div>The total number of consultations in the program up to the present date has been 31,901, increasing from 3,934 in 2018 to 9,508 in 2023. The estimated prevalence of DR is 15.41%. 1.58% of patients were referred to their reference hospitals due to DR or other pathologies requiring urgent treatment. The remaining patients were managed by the program.</div></div><div><h3>Conclusions</h3><div>The prevalence of DR appears to be slightly lower than that reported in other published series, but no significant differences were observed between different program years, overall assessment, or different forms of DR or suspected diabetic macular oedema.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 377-385"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2025.02.002
F. Calleja Casado , B. Juan Ribelles , S.A. Maugard Tepper , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper
Acute macular neuroretinopathy (AMN) is a rare retinal condition characterized by paracentral scotomas and typical wedge-shaped lesions in the outer retina, often affecting young, otherwise healthy individuals. We report a case of AMN associated with dengue virus infection in a 48-year-old female doctor presenting with sudden onset of visual disturbances during a febrile illness after working away in Africa. Ophthalmologic examination and multimodal imaging, including optical coherence tomography and fundus autofluorescence, revealed characteristic outer retinal changes consistent with AMN. Dengue infection was confirmed through serologic testing, and no other systemic or ocular conditions were identified, apart from fever and myalgias.
The pathophysiology of AMN in the context of dengue virus remains unclear, though it may involve ischemic damage to the deep retinal capillary plexus due to systemic inflammation, endothelial dysfunction, or immune-mediated mechanisms. This case underscores the importance of considering dengue virus infection in the differential diagnosis of AMN and/or foveolitis, particularly in endemic regions. Early recognition and diagnosis are critical for appropriate management and follow up, though no specific treatment for AMN exists. This case adds to the growing body of literature on the ocular manifestations of viral infections, specifically dengue, and highlights the need for further research into the underlying mechanisms and potential therapeutic interventions.
{"title":"Neurorretinopatía macular aguda asociada a infección por el virus del dengue","authors":"F. Calleja Casado , B. Juan Ribelles , S.A. Maugard Tepper , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper","doi":"10.1016/j.oftal.2025.02.002","DOIUrl":"10.1016/j.oftal.2025.02.002","url":null,"abstract":"<div><div>Acute macular neuroretinopathy (AMN) is a rare retinal condition characterized by paracentral scotomas and typical wedge-shaped lesions in the outer retina, often affecting young, otherwise healthy individuals. We report a case of AMN associated with dengue virus infection in a 48-year-old female doctor presenting with sudden onset of visual disturbances during a febrile illness after working away in Africa. Ophthalmologic examination and multimodal imaging, including optical coherence tomography and fundus autofluorescence, revealed characteristic outer retinal changes consistent with AMN. Dengue infection was confirmed through serologic testing, and no other systemic or ocular conditions were identified, apart from fever and myalgias.</div><div>The pathophysiology of AMN in the context of dengue virus remains unclear, though it may involve ischemic damage to the deep retinal capillary plexus due to systemic inflammation, endothelial dysfunction, or immune-mediated mechanisms. This case underscores the importance of considering dengue virus infection in the differential diagnosis of AMN and/or foveolitis, particularly in endemic regions. Early recognition and diagnosis are critical for appropriate management and follow up, though no specific treatment for AMN exists. This case adds to the growing body of literature on the ocular manifestations of viral infections, specifically dengue, and highlights the need for further research into the underlying mechanisms and potential therapeutic interventions.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 421-425"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2024.10.014
F. Gonzalez-Lopez, S. Delgado-Tirado, E. Sevillano, E. Corral-Carrasquilla, D. Medel
As a result of the successful development of corneal refractive techniques over the past three decades, an increasing number of patients who have undergone refractive surgery are now seeking surgical solutions for dysfunctional or cataractous lenses, with high expectations for precise visual outcomes. Refractive calculation in these cases poses a challenge for the surgeon. One available option to address residual postoperative refractive errors after lensectomy is the implantation of a secondary intraocular lens in a piggyback configuration. We present a unique case of implanting a collamer phakic intraocular lens (ICL) in a piggyback fashion, addressing not only residual refractive error following cataract surgery but also severe negative dysphotopsia in a patient who had undergone LASIK 20 years earlier and already had a posterior capsulotomy.
{"title":"Lente intraocular fáquica de colámero tórica implantada en piggyback: manejo de la ametropía pseudofáquica y la disfotopsia negativa","authors":"F. Gonzalez-Lopez, S. Delgado-Tirado, E. Sevillano, E. Corral-Carrasquilla, D. Medel","doi":"10.1016/j.oftal.2024.10.014","DOIUrl":"10.1016/j.oftal.2024.10.014","url":null,"abstract":"<div><div>As a result of the successful development of corneal refractive techniques over the past three decades, an increasing number of patients who have undergone refractive surgery are now seeking surgical solutions for dysfunctional or cataractous lenses, with high expectations for precise visual outcomes. Refractive calculation in these cases poses a challenge for the surgeon. One available option to address residual postoperative refractive errors after lensectomy is the implantation of a secondary intraocular lens in a piggyback configuration. We present a unique case of implanting a collamer phakic intraocular lens (ICL) in a piggyback fashion, addressing not only residual refractive error following cataract surgery but also severe negative dysphotopsia in a patient who had undergone LASIK 20<!--> <!-->years earlier and already had a posterior capsulotomy.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 426-430"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2024.12.006
A. Arnaiz-Camacho, C. Parés-Alfonso, L. Sánchez-Vela
{"title":"La noche estrellada: turbulencias de pigmento tras iridotomía periférica en iris bombé","authors":"A. Arnaiz-Camacho, C. Parés-Alfonso, L. Sánchez-Vela","doi":"10.1016/j.oftal.2024.12.006","DOIUrl":"10.1016/j.oftal.2024.12.006","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 439-440"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.oftal.2025.03.007
M. Comes-Carsí, J.M. Vilaplana-Mora, L. Manfreda-Domínguez, C. Cañete-Nicolás, A.M. Duch-Samper
Objective
The main objective is to determine if there are differences in visual function and retinal structure in patients with bipolar disorder compared to healthy subjects.
Material and methods
Cross-sectional observational study of cases and controls, adjusted for age and sex. A total of 43 controls (86 eyes) and 82 cases (163 eyes) were included. Visual function was assessed by measuring best corrected visual acuity (BCVA) using high contrast and low contrast visual charts. Optical coherence tomography (OCT) model DRI OCT Triton-Swept Source (Topcon, Tokyo, Japón) was used for retinal structural analysis.
Results
BCVA with high contrast, as well as with reduced contrast at 2.5% and 1.25%, showed significant differences (P<.05) between both groups, being the mean of each variable lower in the case group. OCT analysis also showed significant differences in the mean thickness of the nerve fiber layer (RNFL) and ganglion cell layer (GCL) between the two groups, with the mean of each variable lower in the case group (P=.007 in both). No significant differences were observed in the mean thickness of these retinal layers between type I and type II bipolar patients (P=.556 and 0.871 respectively).
Conclusions
There are significant differences in visual function and in the mean thickness of retinal layers between bipolar patients and healthy controls.
目的主要目的是确定双相情感障碍患者的视觉功能和视网膜结构与健康受试者相比是否存在差异。材料和方法病例和对照的横断面观察研究，调整了年龄和性别。共纳入43例对照组（86只眼）和82例病例（163只眼）。采用高对比度和低对比度视力表测量最佳矫正视力（BCVA）评估视觉功能。光学相干断层扫描（OCT）模型DRI OCT triton - sweep Source （Topcon, Tokyo, Japón）用于视网膜结构分析。结果高对比度的bcva，以及2.5%和1.25%对比度降低的bcva，两组之间存在显著差异（P< 0.05），为病例组各变量的平均值。OCT分析还显示，两组患者神经纤维层（RNFL）和神经节细胞层（GCL）的平均厚度也有显著差异，病例组各变量的平均值较低(P=。007)。在I型和II型双相患者之间，这些视网膜层的平均厚度没有显著差异(P=。556和0.871)。结论双相情感障碍患者的视功能和视网膜层平均厚度与健康对照有显著差异。
{"title":"Alteraciones en la función visual y en la estructura retiniana de los pacientes con trastorno bipolar","authors":"M. Comes-Carsí, J.M. Vilaplana-Mora, L. Manfreda-Domínguez, C. Cañete-Nicolás, A.M. Duch-Samper","doi":"10.1016/j.oftal.2025.03.007","DOIUrl":"10.1016/j.oftal.2025.03.007","url":null,"abstract":"<div><h3>Objective</h3><div>The main objective is to determine if there are differences in visual function and retinal structure in patients with bipolar disorder compared to healthy subjects.</div></div><div><h3>Material and methods</h3><div>Cross-sectional observational study of cases and controls, adjusted for age and sex. A total of 43 controls (86 eyes) and 82 cases (163 eyes) were included. Visual function was assessed by measuring best corrected visual acuity (BCVA) using high contrast and low contrast visual charts. Optical coherence tomography (OCT) model DRI OCT Triton-Swept Source (Topcon, Tokyo, Japón<em>)</em> was used for retinal structural analysis.</div></div><div><h3>Results</h3><div>BCVA with high contrast, as well as with reduced contrast at 2.5% and 1.25%, showed significant differences (<em>P</em><.05) between both groups, being the mean of each variable lower in the case group. OCT analysis also showed significant differences in the mean thickness of the nerve fiber layer (RNFL) and ganglion cell layer (GCL) between the two groups, with the mean of each variable lower in the case group (<em>P</em>=.007 in both). No significant differences were observed in the mean thickness of these retinal layers between type I and type II bipolar patients (<em>P</em>=.556 and 0.871 respectively).</div></div><div><h3>Conclusions</h3><div>There are significant differences in visual function and in the mean thickness of retinal layers between bipolar patients and healthy controls.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 7","pages":"Pages 386-391"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-24DOI: 10.1016/j.oftal.2025.05.001
D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano
A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.
{"title":"Enfermedad de Stargardt por mutación en ABCA4 en un adulto joven: reporte de caso y alternativas actuales de tratamientos ópticos y médicos","authors":"D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano","doi":"10.1016/j.oftal.2025.05.001","DOIUrl":"10.1016/j.oftal.2025.05.001","url":null,"abstract":"<div><div>A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 9","pages":"Pages 571-575"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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