Pub Date : 2023-09-18DOI: 10.9734/ajocs/2023/v13i5255
Famurewa, Oluwayemisi Juliannah
Moringa oleifera (Moringaceae) which grows in the tropical and subtropical regions of the world, has long unani system of medicine with ayurvedic history. The seeds are known to possess high medicinal properties. This study aimed to determine the antioxidant activity of M. oleifera seeds, extracted with different solvents (methanol, ethyl acetate and n-hexane) using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This research was carried out using different concentrations of methanol, ethyl acetate, and n-hexane extracts, (5, 10, 15, 20, 25, 30 mg/mL). Vitamin C was also used as standard antioxidant control. The percentage of inhibition and IC50 were measured. The results showed that the DPPH free radicals were scavenged by all seed extracts in a concentration dependent manner. Moreover, the IC50 values for DPPH radicals with methanol, ethyl acetate and n-hexane extract of the M. oleifera seeds were found to be 30.77, 44.77 and 45.04 mg/mL, respectively. Interestingly, the IC50 value of all the extracts revealed very active antioxidant activity but lower than the standard vitamin C due to their IC50 values < 50 mg/mL. The order of activity for all the assay was methanol > ethyl acetate > n-hexane. The results suggested that methanol extract of M. oleifera seeds has the most active antioxidant activity.
{"title":"Antioxidant Activities of Different Solvent Extracts of Moringa oleifera Seeds Using DPPH Assay","authors":"Famurewa, Oluwayemisi Juliannah","doi":"10.9734/ajocs/2023/v13i5255","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i5255","url":null,"abstract":"Moringa oleifera (Moringaceae) which grows in the tropical and subtropical regions of the world, has long unani system of medicine with ayurvedic history. The seeds are known to possess high medicinal properties. This study aimed to determine the antioxidant activity of M. oleifera seeds, extracted with different solvents (methanol, ethyl acetate and n-hexane) using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This research was carried out using different concentrations of methanol, ethyl acetate, and n-hexane extracts, (5, 10, 15, 20, 25, 30 mg/mL). Vitamin C was also used as standard antioxidant control. The percentage of inhibition and IC50 were measured. The results showed that the DPPH free radicals were scavenged by all seed extracts in a concentration dependent manner. Moreover, the IC50 values for DPPH radicals with methanol, ethyl acetate and n-hexane extract of the M. oleifera seeds were found to be 30.77, 44.77 and 45.04 mg/mL, respectively. Interestingly, the IC50 value of all the extracts revealed very active antioxidant activity but lower than the standard vitamin C due to their IC50 values < 50 mg/mL. The order of activity for all the assay was methanol > ethyl acetate > n-hexane. The results suggested that methanol extract of M. oleifera seeds has the most active antioxidant activity.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-18DOI: 10.9734/ajocs/2023/v13i5256
Taye Temitope Alawode
Several alkaloids with anticancer activities have been reported among the Crinum species. In this study, an in silico screening of crinine alkaloids was carried out to identify potential Caspase-3 activators and anti-angiogenic compounds. Thirty-one (31) crinine alkaloids were assessed for drug-likeness using the SwissADME online Web server. Nine (9) alkaloids, satisfying Lipinski’s rules for drug-likeness were selected and screened in silico for cytotoxic properties against cancer and normal cell lines using the Cell Line Cytotoxity Predictor (CLC-Pred). The alkaloids possessing drug-like properties and showing good selectivity towards cancer cell lines were evaluated for Caspase-3 activating and anti-angiogenic activities by docking with the Caspase-3 and VEGFR2 proteins, respectively. The binding energy of the compounds was compared with those of the standard drugs. Powelline, augustine, and undulatine possess drug-like properties and demonstrated good selectivity against lung cancer (A549) and oligodendroglioma (Hs683) cell lines. Among these three compounds, powelline had the best potential as a Caspase-3 stimulant and anti-angiogenic agent. Powelline, augustine, and undulatine are potential lead anticancer agents against human lung cancer and oligodendroglioma.
{"title":"Lead Anticancer Agents of Crinine Alkaloids: Cytotoxic, Caspase-3, and Anti-angiogenic Exploration","authors":"Taye Temitope Alawode","doi":"10.9734/ajocs/2023/v13i5256","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i5256","url":null,"abstract":"Several alkaloids with anticancer activities have been reported among the Crinum species. In this study, an in silico screening of crinine alkaloids was carried out to identify potential Caspase-3 activators and anti-angiogenic compounds. Thirty-one (31) crinine alkaloids were assessed for drug-likeness using the SwissADME online Web server. Nine (9) alkaloids, satisfying Lipinski’s rules for drug-likeness were selected and screened in silico for cytotoxic properties against cancer and normal cell lines using the Cell Line Cytotoxity Predictor (CLC-Pred). The alkaloids possessing drug-like properties and showing good selectivity towards cancer cell lines were evaluated for Caspase-3 activating and anti-angiogenic activities by docking with the Caspase-3 and VEGFR2 proteins, respectively. The binding energy of the compounds was compared with those of the standard drugs. Powelline, augustine, and undulatine possess drug-like properties and demonstrated good selectivity against lung cancer (A549) and oligodendroglioma (Hs683) cell lines. Among these three compounds, powelline had the best potential as a Caspase-3 stimulant and anti-angiogenic agent. Powelline, augustine, and undulatine are potential lead anticancer agents against human lung cancer and oligodendroglioma.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-16DOI: 10.9734/ajocs/2023/v13i5254
Francis Olusegun Oladeji, Adepoju Adelola, Tawakalitu T. Abolayo, Oluwaseun Awodele, Ojedeji Kolawole Ayodeji, Olanrewaju John Adedayo
One of the most crucial areas of agriculture is poultry production, with commercial layers and broilers making a significant contribution to supplying the rising need for protein from the growing population through eggs and meats. It's crucial that hens have enough of certain necessary metals like copper (Cu), zinc (Zn), and manganese (Mn) in their meals. We examined the levels of cadmium (Cd), cobalt (Co), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), chromium (Cr), and zinc (Zn) in four brands of two commercial feeds (Animal care and Top feeds) that are often used by chicken farmers in Osun state. The meals were bought at Ijebu-Jesa, Osun State, from several retail establishments. Atomic Absorption Spectrometer (AAS) analysis was done after the feeds had been ashed, digested, and examined for metal contamination. The concentration of the key components was consistently lowest in starting feed. The feed had relatively little of the necessary components (copper, zinc, iron, and manganese). Because of this, the projected nutritional values of the feed based on the concentrations of the necessary components were extremely low. This demonstrates that supplements were not provided to the diets as was reasonable to expect. The feed samples, however, had very high levels of lead. Anthropogenic sources of lead contamination in the environment, particularly fossil fuels, may be to blame for this. Adoption of alternative renewable energy sources like biodiesel and bioethanol is highly necessary.
{"title":"An Evaluation of the Presence of Heavy Metals in the Poultry Feeds Marketed in Ijebu Jesa, Osun State","authors":"Francis Olusegun Oladeji, Adepoju Adelola, Tawakalitu T. Abolayo, Oluwaseun Awodele, Ojedeji Kolawole Ayodeji, Olanrewaju John Adedayo","doi":"10.9734/ajocs/2023/v13i5254","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i5254","url":null,"abstract":"One of the most crucial areas of agriculture is poultry production, with commercial layers and broilers making a significant contribution to supplying the rising need for protein from the growing population through eggs and meats. It's crucial that hens have enough of certain necessary metals like copper (Cu), zinc (Zn), and manganese (Mn) in their meals. We examined the levels of cadmium (Cd), cobalt (Co), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), chromium (Cr), and zinc (Zn) in four brands of two commercial feeds (Animal care and Top feeds) that are often used by chicken farmers in Osun state. The meals were bought at Ijebu-Jesa, Osun State, from several retail establishments. Atomic Absorption Spectrometer (AAS) analysis was done after the feeds had been ashed, digested, and examined for metal contamination. The concentration of the key components was consistently lowest in starting feed. The feed had relatively little of the necessary components (copper, zinc, iron, and manganese). Because of this, the projected nutritional values of the feed based on the concentrations of the necessary components were extremely low. This demonstrates that supplements were not provided to the diets as was reasonable to expect. The feed samples, however, had very high levels of lead. Anthropogenic sources of lead contamination in the environment, particularly fossil fuels, may be to blame for this. Adoption of alternative renewable energy sources like biodiesel and bioethanol is highly necessary.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135308118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.9734/ajocs/2023/v13i5253
Ammara Yaseen, Adnan Yasin, Akasha Saleem, Faqeer Muhammad, Rafia Ismail, Muhammad Ismaeel, Ihsan Ali, Zarwali Khan, Muhammad Usman, Muhammad Ramzan, Tayyaba Shabir, Zobia Yaseen, Nasir Abbas
Nano Ni – Aluminates (Ni0.5 Fe0.5 Al2O4) and Cd Doped Nano Ni – Aluminates (Ni0.5 Fe0.5 Al2-x CdxO4) where x = 0.2, 0.4, 0.6 and 0.8 were synthesized by co-precipitation method. Ammonium hydroxide was used as precipitating agent. The samples were characterized using Fourier transform infrared spectroscopy. FTIR spectrum for each unannealed sample of Ni0.5 Fe0.5 Al2 O4 and Ni0.5 Fe0.5 Al2-x Cdx O4 exhibit a broad band near 3450 cm-1 due to –OH stretching vibration of free hydrogen bonded hydroxyl group and a second typical absorption band at 1620 cm-1 resulting from deformative vibration of water molecules. Spectra for samples after annealing show peaks in the range of 900-450 cm-1 and 850-500 cm-1 showing presence of Al-O and Ni-O bonds respectively thus confirm the formation of metal oxides bonds while no peak was observed for –OH bond. A peak around 420 cm-1 is assigned to Cd-O bond.
{"title":"Synthesis and FTIR Analysis of Cd Doped Nano Ni - Aluminates","authors":"Ammara Yaseen, Adnan Yasin, Akasha Saleem, Faqeer Muhammad, Rafia Ismail, Muhammad Ismaeel, Ihsan Ali, Zarwali Khan, Muhammad Usman, Muhammad Ramzan, Tayyaba Shabir, Zobia Yaseen, Nasir Abbas","doi":"10.9734/ajocs/2023/v13i5253","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i5253","url":null,"abstract":"Nano Ni – Aluminates (Ni0.5 Fe0.5 Al2O4) and Cd Doped Nano Ni – Aluminates (Ni0.5 Fe0.5 Al2-x CdxO4) where x = 0.2, 0.4, 0.6 and 0.8 were synthesized by co-precipitation method. Ammonium hydroxide was used as precipitating agent. The samples were characterized using Fourier transform infrared spectroscopy. FTIR spectrum for each unannealed sample of Ni0.5 Fe0.5 Al2 O4 and Ni0.5 Fe0.5 Al2-x Cdx O4 exhibit a broad band near 3450 cm-1 due to –OH stretching vibration of free hydrogen bonded hydroxyl group and a second typical absorption band at 1620 cm-1 resulting from deformative vibration of water molecules. Spectra for samples after annealing show peaks in the range of 900-450 cm-1 and 850-500 cm-1 showing presence of Al-O and Ni-O bonds respectively thus confirm the formation of metal oxides bonds while no peak was observed for –OH bond. A peak around 420 cm-1 is assigned to Cd-O bond.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.9734/ajocs/2023/v13i5252
Zobia Yaseen, Tabinda Jabeen, Ashraf Hussain, Muhammad Ismaeel, Tayyaba Munawar, Ammara Yaseen, Muhammad Ramzan, Zarwali Khan, Tayyaba Shabir, Nasir Abbas
Water is essential for living organisms, with our bodies containing a significant 60% water content. Water pollution resulting from harmful industrial practices and human activities poses a significant danger to humanity. The release of organic and inorganic substances, pathogens, herbicides, pesticides, drugs, heavy metals, and visible pollutants into water bodies leads to a decline in water quality, causing a reduction in oxygen levels. The toxicity and bioaccumulative properties of heavy metals make them prominent environmental pollutants. Researchers are particularly interested in the adsorption method due to its exceptional ability to eliminate toxic metals, wherein adsorbates bind to the solid surface of adsorbents through physicochemical interactions. In this study, TiO2 nanoparticles were synthesized via solgel method. These nanoparticles were used to remove lead from contaminated water. Various techniques, including XRD and EDX were employed to analyze the nanoparticle synthesis. The Atomic Absorption Spectrophotometer was used to measure the removal of Lead before and after adsorption. Key variables like pH, dosage, and contact time were carefully controlled in the experiments. To ensure the findings, statistical analysis were applied to examine all collected data. The ultimate aim was to enhance the efficiency of heavy metal removal and offer valuable insights into the use of chemically synthesized TiO2 nanoparticles for water purification purposes. This research has the potential to contribute to safer water resources and improved environmental management.
{"title":"Kinetics and Mechanism of Lead Removal from Effluents by Synthesized TiO2 Nanoparticles Via Sol-Gel Method: Adsorption Studies","authors":"Zobia Yaseen, Tabinda Jabeen, Ashraf Hussain, Muhammad Ismaeel, Tayyaba Munawar, Ammara Yaseen, Muhammad Ramzan, Zarwali Khan, Tayyaba Shabir, Nasir Abbas","doi":"10.9734/ajocs/2023/v13i5252","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i5252","url":null,"abstract":"Water is essential for living organisms, with our bodies containing a significant 60% water content. Water pollution resulting from harmful industrial practices and human activities poses a significant danger to humanity. The release of organic and inorganic substances, pathogens, herbicides, pesticides, drugs, heavy metals, and visible pollutants into water bodies leads to a decline in water quality, causing a reduction in oxygen levels. The toxicity and bioaccumulative properties of heavy metals make them prominent environmental pollutants. Researchers are particularly interested in the adsorption method due to its exceptional ability to eliminate toxic metals, wherein adsorbates bind to the solid surface of adsorbents through physicochemical interactions. In this study, TiO2 nanoparticles were synthesized via solgel method. These nanoparticles were used to remove lead from contaminated water. Various techniques, including XRD and EDX were employed to analyze the nanoparticle synthesis. The Atomic Absorption Spectrophotometer was used to measure the removal of Lead before and after adsorption. Key variables like pH, dosage, and contact time were carefully controlled in the experiments. To ensure the findings, statistical analysis were applied to examine all collected data. The ultimate aim was to enhance the efficiency of heavy metal removal and offer valuable insights into the use of chemically synthesized TiO2 nanoparticles for water purification purposes. This research has the potential to contribute to safer water resources and improved environmental management.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135980366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-19DOI: 10.9734/ajocs/2023/v14i1251
Zarwali Khan, M. Yaseen, I. Ali, A. Yaseen, Bakar bin Khatab Abbasi, Arslan Ali, Khalid Mehmood, Muhammad Ibrahim, Tayyaba Shabir, Fakiha Nazakat, Zobia Yaseen, N. Abbas
Pharmaceutical medications must be stable to preserve their efficacy and safety over the period of their shelf lives. Studies on force degradation are crucial for identifying probable degradation pathways and identifying extreme stresses that may lead to the breakdown of the pharmaceutical product. This report offers a thorough analysis of the force degradation tests performed on Clomifene citrate tablets. Evaluation of the effects of several stress factors, including temperature, humidity, light, and mechanical forces, on the stability of clomifene citrate is the main goal. To replicate actual storage and handling situations, the study used stress testing criteria specified by the International Conference on Harmonization (ICH). According to the study, temperature and humidity have the biggest roles in the degradation of Clomifene citrate tablets. In this article the FDS was performed by using a stainless-steel column (250 mm x 4.6 mm) packed with Butylsilane C4 (5µm) L26, detector 233nm, mobile phase; mobile Phase was prepared by mixing 550 volumes of methanol, 450 volumes of water and 3 volumes of triethylamine. Then adjust the pH to 2.5 with phosphoric acid. Flow rate; 1 mL/mint. The quantification and hyphenation of the instrumental analysis were successfully accomplished using the developed method.
药品必须是稳定的，以便在其保质期内保持其有效性和安全性。对力降解的研究对于确定可能的降解途径和确定可能导致药品分解的极端应力至关重要。本报告对枸橼酸克罗米芬片的力降解试验进行了全面分析。评价温度、湿度、光和机械力等几种应力因素对柠檬酸克罗米芬稳定性的影响是主要目标。为了模拟实际的储存和处理情况，该研究使用了国际协调会议(ICH)规定的压力测试标准。研究表明，温度和湿度对枸橼酸克罗米芬片的降解作用最大。本文采用不锈钢柱(250 mm × 4.6 mm)，填充丁基硅烷C4(5µm) L26，检测器233nm，流动相;流动相由550体积甲醇、450体积水和3体积三乙胺混合制备。然后用磷酸将pH调至2.5。流量;1毫升/薄荷。该方法成功地完成了仪器分析的定量和分节。
{"title":"Forced Degradation and Stability Indicating Studies for Clomifene Citrate Tablet","authors":"Zarwali Khan, M. Yaseen, I. Ali, A. Yaseen, Bakar bin Khatab Abbasi, Arslan Ali, Khalid Mehmood, Muhammad Ibrahim, Tayyaba Shabir, Fakiha Nazakat, Zobia Yaseen, N. Abbas","doi":"10.9734/ajocs/2023/v14i1251","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v14i1251","url":null,"abstract":"Pharmaceutical medications must be stable to preserve their efficacy and safety over the period of their shelf lives. Studies on force degradation are crucial for identifying probable degradation pathways and identifying extreme stresses that may lead to the breakdown of the pharmaceutical product. This report offers a thorough analysis of the force degradation tests performed on Clomifene citrate tablets. Evaluation of the effects of several stress factors, including temperature, humidity, light, and mechanical forces, on the stability of clomifene citrate is the main goal. To replicate actual storage and handling situations, the study used stress testing criteria specified by the International Conference on Harmonization (ICH). According to the study, temperature and humidity have the biggest roles in the degradation of Clomifene citrate tablets. In this article the FDS was performed by using a stainless-steel column (250 mm x 4.6 mm) packed with Butylsilane C4 (5µm) L26, detector 233nm, mobile phase; mobile Phase was prepared by mixing 550 volumes of methanol, 450 volumes of water and 3 volumes of triethylamine. Then adjust the pH to 2.5 with phosphoric acid. Flow rate; 1 mL/mint. The quantification and hyphenation of the instrumental analysis were successfully accomplished using the developed method.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90541037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.9734/ajocs/2023/v14i1250
Zobia Yaseen, Khalid Mehmood, M. Ibrahim, A. Yaseen, A. Ihsan, A. Raza, Akaash Hassan, G. Shabir, Tayyaba Shabir, N. Abbas
Water plays a remarkable role in the natural structure of a living organism as people's bodies comprise 60% water by weight. Water contamination due to negative industrialization and anthropogenic activities is a huge hazard to humanity. The water quality is degraded by the discharge of organic and Inorganic compounds, Pathogens, herbicides, pesticides, drugs, heavy metals, and macroscopic pollutants in the water bodies, leading to a decrease in the oxygen in the water. Heavy metals are well-defined habitat pollutants because of their toxicity and bio accumulative nature. The adsorption method is more appealing to researchers because of its extraordinary potential to remove toxic metals, in which adsorbate are attached to the solid surface of adsorbent through physiochemical interactions. In the current research, the plant leaf extract of Ziziphus mauritiana was subjected to synthesize TiO2. For Chromium removal from an aqueous solution, TiO2 nanoparticles will be used. UV-Visible, FTIR, powder and SEM will be employed to characterize nanoparticle synthesis. Atomic Absorption Spectrophotometer will be employed for heavy metal removal analysis before and after adsorption. pH, dosage rate, concentration, and contact time were among the various experimental activities used. Finally, to improve the results, experimental statistics were applied to all recorded data.
{"title":"Efficient Adsorption Kinetic Studies of Chromium from Effluents Using Ziziphus mauritiana Leaf Extract Mediated TiO2 Nanoparticles","authors":"Zobia Yaseen, Khalid Mehmood, M. Ibrahim, A. Yaseen, A. Ihsan, A. Raza, Akaash Hassan, G. Shabir, Tayyaba Shabir, N. Abbas","doi":"10.9734/ajocs/2023/v14i1250","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v14i1250","url":null,"abstract":"Water plays a remarkable role in the natural structure of a living organism as people's bodies comprise 60% water by weight. Water contamination due to negative industrialization and anthropogenic activities is a huge hazard to humanity. The water quality is degraded by the discharge of organic and Inorganic compounds, Pathogens, herbicides, pesticides, drugs, heavy metals, and macroscopic pollutants in the water bodies, leading to a decrease in the oxygen in the water. Heavy metals are well-defined habitat pollutants because of their toxicity and bio accumulative nature. The adsorption method is more appealing to researchers because of its extraordinary potential to remove toxic metals, in which adsorbate are attached to the solid surface of adsorbent through physiochemical interactions. In the current research, the plant leaf extract of Ziziphus mauritiana was subjected to synthesize TiO2. For Chromium removal from an aqueous solution, TiO2 nanoparticles will be used. UV-Visible, FTIR, powder and SEM will be employed to characterize nanoparticle synthesis. Atomic Absorption Spectrophotometer will be employed for heavy metal removal analysis before and after adsorption. pH, dosage rate, concentration, and contact time were among the various experimental activities used. Finally, to improve the results, experimental statistics were applied to all recorded data.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90152188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-02DOI: 10.9734/ajocs/2023/v14i1249
Tayyaba Shabir, Wardah Hassan, N. Abbas, Fakhar-un-Nisa, M. N. Akhtar, Zobia Yaseen, A. Yaseen, A. Ihsan, Mariam Khan
Novel water purification technologies are emerging to satisfy the requirement of clean drinking water for human life. The development of long-term water treatment systems is a serious concern. In this regard, nanotechnology holds enormous promise for improving the effectiveness and efficiency of polluted water remediation. The goal of this work was to create a simple and effective water purification system that used cost-effective, durable, and environmentally friendly novel materials. Green nanoparticle synthesis has emerged as a result of recent advancements in environmentally friendly technologies. The use of plant extract to synthesize nanoparticles is thought to be an incredible green strategy. In the present study, leaf extract of Ficus benghalensis was chosen to synthesize the low cost and novel copper oxide (CuO) nanoparticles. The aim was to investigate the ability of these novel nano particles in removing Congo red dye from water. Various parameters including contact time, adsorbent dosage, initial dye concentration and pH of dye solution that affect the adsorption were optimized by carrying out batch adsorption experiments. The mechanism of pseudo-first-order, pseudo-second-order, Langmuir equilibrium isotherm, and Freundlich isotherm was investigated using kinetic and equilibrium experimental data. These models gave an insight into the adsorption kinetics and adsorption mechanism. The pH effect revealed that Congo red dye being an acidic dye showed good adsorption at acidic pH. The findings of this work show that copper oxide nanoparticles are promising adsorbents for the removal of Congo red dye from aqueous based system.
{"title":"Removal of Congo Red Dye Using Ficus benghalensis-Assisted Copper Oxide Nanoparticles","authors":"Tayyaba Shabir, Wardah Hassan, N. Abbas, Fakhar-un-Nisa, M. N. Akhtar, Zobia Yaseen, A. Yaseen, A. Ihsan, Mariam Khan","doi":"10.9734/ajocs/2023/v14i1249","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v14i1249","url":null,"abstract":"Novel water purification technologies are emerging to satisfy the requirement of clean drinking water for human life. The development of long-term water treatment systems is a serious concern. In this regard, nanotechnology holds enormous promise for improving the effectiveness and efficiency of polluted water remediation. The goal of this work was to create a simple and effective water purification system that used cost-effective, durable, and environmentally friendly novel materials. Green nanoparticle synthesis has emerged as a result of recent advancements in environmentally friendly technologies. The use of plant extract to synthesize nanoparticles is thought to be an incredible green strategy. \u0000In the present study, leaf extract of Ficus benghalensis was chosen to synthesize the low cost and novel copper oxide (CuO) nanoparticles. The aim was to investigate the ability of these novel nano particles in removing Congo red dye from water. Various parameters including contact time, adsorbent dosage, initial dye concentration and pH of dye solution that affect the adsorption were optimized by carrying out batch adsorption experiments. The mechanism of pseudo-first-order, pseudo-second-order, Langmuir equilibrium isotherm, and Freundlich isotherm was investigated using kinetic and equilibrium experimental data. These models gave an insight into the adsorption kinetics and adsorption mechanism. The pH effect revealed that Congo red dye being an acidic dye showed good adsorption at acidic pH. The findings of this work show that copper oxide nanoparticles are promising adsorbents for the removal of Congo red dye from aqueous based system.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81130288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.9734/ajocs/2023/v13i4248
Tejaswini P. Masne, Shyam Rangari, K. Gupta, M. Umekar
Aims: The devised method for estimating hydroxychloroquine sulphate in bulk and pharmaceutical dose forms (tablets) is the subject of this work. The method can therefore be applied to regular quantitative analysis and stability. The following describes the planned work's goal and scope: To create an appropriate spectrophotometric method for tablet-based hydroxychloroquine sulphate estimation. Carry out the method's validation. Methodology: These techniques include the area under curve (AUC) method-I and the A1% solution method based on absorbance measurement, or method-II, both of which are chosen at wavelengths of 329.4 nm using a UV-visible spectrophotometer with a 1 cm matched quartz cell and 0.01N acetic acid with water as a solvent. Results: Plots of the hydroxychloroquine sulphate absorption spectra in 0.01N acetic acid were made. 329.4 nm was found to be the average maximum. With correlation coefficients of 0.9992 and 0.999 (r2>0.999) for AUC and 1%, respectively, and a linear connection between the absorbance and drug concentration in concentration ranges of 5-35 g/mL, it is clear that the method is linear. The percentage of medication calculated by various methods was close to 100.12, and 99.41% of the results were consistent with the label claim of the commercially available tablet formulation. As per ICH requirements, the validation parameter research was completed. Conclusion: The described UV methods offer good accuracy and precision with reduced limits of detection and quantification. They are straightforward, trustworthy, and highly selective. These disclosed methods are ideal for routine quantitative analysis in pharmaceutical dosage forms due to the decreased time required for analysis of hydroxychloroquine sulphate. The time-saving, low-cost alternative to the expensive high-performance liquid chromatographic technology is the applied spectrophotometric approaches.
{"title":"Method Development and Validation of UV-Spectrophotometric Estimation of Hydroxychloroquine Sulphate in Bulk and Pharmaceutical Dosage Form","authors":"Tejaswini P. Masne, Shyam Rangari, K. Gupta, M. Umekar","doi":"10.9734/ajocs/2023/v13i4248","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i4248","url":null,"abstract":"Aims: The devised method for estimating hydroxychloroquine sulphate in bulk and pharmaceutical dose forms (tablets) is the subject of this work. The method can therefore be applied to regular quantitative analysis and stability. The following describes the planned work's goal and scope: \u0000 \u0000To create an appropriate spectrophotometric method for tablet-based hydroxychloroquine sulphate estimation. \u0000Carry out the method's validation. \u0000 \u0000Methodology: These techniques include the area under curve (AUC) method-I and the A1% solution method based on absorbance measurement, or method-II, both of which are chosen at wavelengths of 329.4 nm using a UV-visible spectrophotometer with a 1 cm matched quartz cell and 0.01N acetic acid with water as a solvent. \u0000Results: Plots of the hydroxychloroquine sulphate absorption spectra in 0.01N acetic acid were made. 329.4 nm was found to be the average maximum. With correlation coefficients of 0.9992 and 0.999 (r2>0.999) for AUC and 1%, respectively, and a linear connection between the absorbance and drug concentration in concentration ranges of 5-35 g/mL, it is clear that the method is linear. The percentage of medication calculated by various methods was close to 100.12, and 99.41% of the results were consistent with the label claim of the commercially available tablet formulation. As per ICH requirements, the validation parameter research was completed. \u0000Conclusion: The described UV methods offer good accuracy and precision with reduced limits of detection and quantification. They are straightforward, trustworthy, and highly selective. These disclosed methods are ideal for routine quantitative analysis in pharmaceutical dosage forms due to the decreased time required for analysis of hydroxychloroquine sulphate. The time-saving, low-cost alternative to the expensive high-performance liquid chromatographic technology is the applied spectrophotometric approaches.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75288905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.9734/ajocs/2023/v13i4247
Xinyu Yan, G. Xiang, Xinyu Wang, Junli Li, Mengyao He, Xing Liu
Rapid, green and high yield synthesis of nitrogen doped carbon dots(N-CDs) through exothermic decomposition reaction of H2O2 using grasshopper powder as precursor and polyethyleneimine (PEI) as a surface passivation reagent. Water-soluble fluorescent N-CDs can be obtained by reacting 5 minutes and purified N-CDs were obtained after an activated carbon adsorption separation procedure with a product yield of 53.3%. TEM, FT-IR, XPS, fluorescence and UV-vis spectra were used to investigate the morphology, elemental information and optical properties of N-CDs. The results indicated that the fluorescence emission of N-CDs is typical excitation wavelength dependent with a strongest emission peak at 417 nm under 330 nm excitation wavelength. There is a good linear response between the fluorescence intensity of N-CDs and temperature, which makes N-CDs a potential nanothermometer to monitor temperature. The great spectral overlap between the blue emission peak (417 nm) of N-CDs and the absorption peak (430 nm) of tartrazine (TAR) leads to an effectively fluorescence quenching phenomenon by TAR through inner filter effect (IFE) and the fluorescence quenching degree (lg(I0/I)) was linearly response to the TAR concentration in the range of 1-100 µM. The detection limit of developed method is 54.3 nM for TAR, and the relative standard deviation (RSD) is 1.14% (n=7, c=10 μM). The N-CDs came from an exothermic reaction is a highly selective and sensitive fluorescent probe for TAR, and it was successfully applied to the determination of TAR in food samples with satisfactory results.
{"title":"High Product Yield Synthesis of Nitrogen Doped Carbon Dots through Exothermic Reaction for Temperature Sensing and Tartrazine Detection","authors":"Xinyu Yan, G. Xiang, Xinyu Wang, Junli Li, Mengyao He, Xing Liu","doi":"10.9734/ajocs/2023/v13i4247","DOIUrl":"https://doi.org/10.9734/ajocs/2023/v13i4247","url":null,"abstract":"Rapid, green and high yield synthesis of nitrogen doped carbon dots(N-CDs) through exothermic decomposition reaction of H2O2 using grasshopper powder as precursor and polyethyleneimine (PEI) as a surface passivation reagent. Water-soluble fluorescent N-CDs can be obtained by reacting 5 minutes and purified N-CDs were obtained after an activated carbon adsorption separation procedure with a product yield of 53.3%. TEM, FT-IR, XPS, fluorescence and UV-vis spectra were used to investigate the morphology, elemental information and optical properties of N-CDs. The results indicated that the fluorescence emission of N-CDs is typical excitation wavelength dependent with a strongest emission peak at 417 nm under 330 nm excitation wavelength. There is a good linear response between the fluorescence intensity of N-CDs and temperature, which makes N-CDs a potential nanothermometer to monitor temperature. The great spectral overlap between the blue emission peak (417 nm) of N-CDs and the absorption peak (430 nm) of tartrazine (TAR) leads to an effectively fluorescence quenching phenomenon by TAR through inner filter effect (IFE) and the fluorescence quenching degree (lg(I0/I)) was linearly response to the TAR concentration in the range of 1-100 µM. The detection limit of developed method is 54.3 nM for TAR, and the relative standard deviation (RSD) is 1.14% (n=7, c=10 μM). The N-CDs came from an exothermic reaction is a highly selective and sensitive fluorescent probe for TAR, and it was successfully applied to the determination of TAR in food samples with satisfactory results.","PeriodicalId":8505,"journal":{"name":"Asian Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81101565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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