Pub Date : 2016-04-25DOI: 10.15272/AJBPS.V6I55.804
A. Eswar, K. Ramamoorthy, Z. Isha, S. Gokulakrishnan
The present work investigates the potential use of the whole tissue of clam Gafrarium divaricatum (Gmelin) as a food source in a coastal region of India. In order to evaluate its food value, a detailed biochemical analysis of the whole tissue has been carried out. The results of biochemical analysis show very high protein content (26.32%), Carbohydrate (11.23%) and lipid (1.29%). The protein consists of 10 essential and 9 non essential amino acids which are as follows (Lysine 14.36%, Histidine 9.02, Methionine 8.92 %) and (Alanine 5.94%, Aspartic acid 4.98, Asparagine 3.79, Tyrosine 3.52 and Proline 3.21%) are the predominant essential amino and non essential amino acids. G. divaricatum consists of 6 different fatty acids out of which 2 are saturated fatty acids (SFA), one monounsaturated fatty acids (MUFA) and three polyunsaturated fatty acids (PUFA). SFA, MUFA and PUFA content was 27.18, 11.02, 12.47, 17.96, 11.38 and 11.38% respectively in fat (1.29 gm/100gm). In addition it contains Vitamins such as Vitamin A (112.3 IU), Vitamin C (24.11 mg/g), D (13.96 IU), B12 (1.98μg/g.), E (1.14 mg/g), K (0.59 mg/g) and B6 (0.31mg/g). Mineral composition of whole tissue showed presence of Calcium 312.74 mg/g, Sodium 89.93mg/g, Magnesium 61.11 mg/g, Potassium 21.38 mg/g as major and Copper 1.43, iron 1.37 and zinc 0.38 mg/g as minor quantity. The test for secondary metabolites shows the presence of alkaloids, phenolics, terpenes, carotenoids and steroids. This shows that the clam species is a good alternative food source to fish and can be very well exploited after its toxicity evaluation. The presence of secondary metabolites will have some medicinal values like hepatoprotective activity and anti oxidant activity which is currently under investigation.
{"title":"Biochemical Composition and Preliminary Qualitative Analysis of Marine ClamGafrarium divaricatum (Gmelin) From Mumbai, West Coast of India","authors":"A. Eswar, K. Ramamoorthy, Z. Isha, S. Gokulakrishnan","doi":"10.15272/AJBPS.V6I55.804","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I55.804","url":null,"abstract":"The present work investigates the potential use of the whole tissue of clam Gafrarium divaricatum (Gmelin) as a food source in a coastal region of India. In order to evaluate its food value, a detailed biochemical analysis of the whole tissue has been carried out. The results of biochemical analysis show very high protein content (26.32%), Carbohydrate (11.23%) and lipid (1.29%). The protein consists of 10 essential and 9 non essential amino acids which are as follows (Lysine 14.36%, Histidine 9.02, Methionine 8.92 %) and (Alanine 5.94%, Aspartic acid 4.98, Asparagine 3.79, Tyrosine 3.52 and Proline 3.21%) are the predominant essential amino and non essential amino acids. G. divaricatum consists of 6 different fatty acids out of which 2 are saturated fatty acids (SFA), one monounsaturated fatty acids (MUFA) and three polyunsaturated fatty acids (PUFA). SFA, MUFA and PUFA content was 27.18, 11.02, 12.47, 17.96, 11.38 and 11.38% respectively in fat (1.29 gm/100gm). In addition it contains Vitamins such as Vitamin A (112.3 IU), Vitamin C (24.11 mg/g), D (13.96 IU), B12 (1.98μg/g.), E (1.14 mg/g), K (0.59 mg/g) and B6 (0.31mg/g). Mineral composition of whole tissue showed presence of Calcium 312.74 mg/g, Sodium 89.93mg/g, Magnesium 61.11 mg/g, Potassium 21.38 mg/g as major and Copper 1.43, iron 1.37 and zinc 0.38 mg/g as minor quantity. The test for secondary metabolites shows the presence of alkaloids, phenolics, terpenes, carotenoids and steroids. This shows that the clam species is a good alternative food source to fish and can be very well exploited after its toxicity evaluation. The presence of secondary metabolites will have some medicinal values like hepatoprotective activity and anti oxidant activity which is currently under investigation.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"2 1 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78293821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-25DOI: 10.15272/ajbps.v6i55.806
K. Nagamani, D. Kaur, G.Abhinayani, G. Goud
Depression is considered as affective mood disorder which is characterized by change in mood, lack of confidence, etc. Depression is the most prevelant disorder and the symptoms associated with depression changes the neurotransmitter levels in brain such as norepinephrine, serotonin and dopamine. Muscle relaxant is a term usually used to refer to skeletal muscle relaxants (drugs), which act on the central nervous system (CNS) to relax muscles. These drugs are often prescribed to reduce pain and soreness associated with sprains, strains, or other types of muscle injury. Basella alba is the plant selected to use as a test drug in experimental animals. After selecting the plant, Leaves has been dried and powdered by using methanol and extracted by using soxhlet apparatus. Evaluation of anti depressant activity as well as skeletal muscle relaxant activity has been done to test the potency of the drug and to know its activity. After comparing the test drug with standard drug Diazepam results has shown that the extract has both anti depressant and skeletal muscle relaxant activities .Therefore, it is concluded that Basella alba extract has good anti depressant and skeletal muscle relaxant activity on mice.
{"title":"Antidepressant and Skeletal Muscle Relaxant Activity of Methanolic Extracts of Basella alba. L","authors":"K. Nagamani, D. Kaur, G.Abhinayani, G. Goud","doi":"10.15272/ajbps.v6i55.806","DOIUrl":"https://doi.org/10.15272/ajbps.v6i55.806","url":null,"abstract":"Depression is considered as affective mood disorder which is characterized by change in mood, lack of confidence, etc. Depression is the most prevelant disorder and the symptoms associated with depression changes the neurotransmitter levels in brain such as norepinephrine, serotonin and dopamine. Muscle relaxant is a term usually used to refer to skeletal muscle relaxants (drugs), which act on the central nervous system (CNS) to relax muscles. These drugs are often prescribed to reduce pain and soreness associated with sprains, strains, or other types of muscle injury. Basella alba is the plant selected to use as a test drug in experimental animals. After selecting the plant, Leaves has been dried and powdered by using methanol and extracted by using soxhlet apparatus. Evaluation of anti depressant activity as well as skeletal muscle relaxant activity has been done to test the potency of the drug and to know its activity. After comparing the test drug with standard drug Diazepam results has shown that the extract has both anti depressant and skeletal muscle relaxant activities .Therefore, it is concluded that Basella alba extract has good anti depressant and skeletal muscle relaxant activity on mice.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"6 1","pages":"07-10"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74014021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-24DOI: 10.15272/AJBPS.V6I54.803
P. Pp, K. Vaishali, Payghan Santosh
The present work was aimed at formulating and physicochemical characterization SNEDDS (self Nano emulsifying drug delivery system) of ezetimibe and evaluating its in vitro and in vivo potential. The solubility of both drugs was determined in excipient screening studies. Pseudoternary phase diagrams were used to evaluate the Nano emulsification existence area, composed of different surfactants, co surfactants, and oils at different surfactant to-cosurfactant (S/CoS) ratios, and the system exhibiting the largest percentage area of the self-Nano emulsifying region was selected and optimum oil ratio in the SNEDDS was selected by evaluating the clarity, precipitation and mean droplet size of the resultant Nanoemulsions. The release rate of ezetimibe was investigated using an in vitro dissolution test. In vitro dissolution studies showed that the SNEDDS composed of Peceol (20% wt/wt), Tween 80 (30% wt/wt), Ethanol (30% wt/wt), and ezetimibe (20% wt/wt) had higher initial dissolution rates for both drugs when compared with plain EZT. More importantly, EZT SNEDDS had a significantly increased dissolution profile in distilled water and pH 4.0 acetate buffer, implying enhanced bioavailability. The underlying mechanism of the loading capacity of EZT was elucidated by measurement of the zeta potential analysis. The results implied that EZT was located both in the Nanoemulsion core and the surfactant–cosurfactant layer. Comparative pharmacokinetic evaluation of EZT SNEDDS was investigated in terms of C max, tmax and AUC using rats. The SNEDDS formulation significantly increases pharmacokinetics parameter as compared with plain ezetimibe. The optimized formulation was then subjected to stability studies and was found to be stable over 6 months. Thus, the study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of ezetimibe to improve its bioavailability
{"title":"Potential Investigation of Peceol for formulation of Ezetimibe self nano emulsifyingDrug Delivery Systems","authors":"P. Pp, K. Vaishali, Payghan Santosh","doi":"10.15272/AJBPS.V6I54.803","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I54.803","url":null,"abstract":"The present work was aimed at formulating and physicochemical characterization SNEDDS (self Nano emulsifying drug delivery system) of ezetimibe and evaluating its in vitro and in vivo potential. The solubility of both drugs was determined in excipient screening studies. Pseudoternary phase diagrams were used to evaluate the Nano emulsification existence area, composed of different surfactants, co surfactants, and oils at different surfactant to-cosurfactant (S/CoS) ratios, and the system exhibiting the largest percentage area of the self-Nano emulsifying region was selected and optimum oil ratio in the SNEDDS was selected by evaluating the clarity, precipitation and mean droplet size of the resultant Nanoemulsions. The release rate of ezetimibe was investigated using an in vitro dissolution test. In vitro dissolution studies showed that the SNEDDS composed of Peceol (20% wt/wt), Tween 80 (30% wt/wt), Ethanol (30% wt/wt), and ezetimibe (20% wt/wt) had higher initial dissolution rates for both drugs when compared with plain EZT. More importantly, EZT SNEDDS had a significantly increased dissolution profile in distilled water and pH 4.0 acetate buffer, implying enhanced bioavailability. The underlying mechanism of the loading capacity of EZT was elucidated by measurement of the zeta potential analysis. The results implied that EZT was located both in the Nanoemulsion core and the surfactant–cosurfactant layer. Comparative pharmacokinetic evaluation of EZT SNEDDS was investigated in terms of C max, tmax and AUC using rats. The SNEDDS formulation significantly increases pharmacokinetics parameter as compared with plain ezetimibe. The optimized formulation was then subjected to stability studies and was found to be stable over 6 months. Thus, the study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of ezetimibe to improve its bioavailability","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"7 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2016-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-07DOI: 10.15272/ajbps.v6i57.841
Ashutosh Kumar Singh
Duodenal ulcer perforation is the second most common abdominal emergency in our study. After invention of the H2 blockers and proton pump inhibitors the role of elective surgery for duodenal ulcer has been drastically decreasing, but the incidence of perforation is not much changing. All the patients are informed consents. The 80 peptic ulcer disease patients were enrolled in to the study. The age group of the patients are from 20-70 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All the patient’s clinical history were collected. Also the complete physical examination was done. The incidence of perforation is more in middle aged males. This trend can be attributed to their increased predisposition to smoking and alcohol. It is noted that post operative pulmonary complications and wound infection are more in the alcoholics and smokers.
{"title":"Complications of Peptic Ulcer Perforation: A Clinical Case Study","authors":"Ashutosh Kumar Singh","doi":"10.15272/ajbps.v6i57.841","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.841","url":null,"abstract":"Duodenal ulcer perforation is the second most common abdominal emergency in our study. After invention of the H2 blockers and proton pump inhibitors the role of elective surgery for duodenal ulcer has been drastically decreasing, but the incidence of perforation is not much changing. All the patients are informed consents. The 80 peptic ulcer disease patients were enrolled in to the study. The age group of the patients are from 20-70 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All the patient’s clinical history were collected. Also the complete physical examination was done. The incidence of perforation is more in middle aged males. This trend can be attributed to their increased predisposition to smoking and alcohol. It is noted that post operative pulmonary complications and wound infection are more in the alcoholics and smokers.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1 1","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78563736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-07DOI: 10.15272/ajbps.v6i57.840
D. Singh
Chronic pancreatitis (CP) is characterised by pancreatic inflammation and fibrosis the endpoint of which is destruction of pancreatic parenchyma with eventual loss of exocrine and endocrine function. Yet the syndrome is well considered in adults, there is incomplete data in children and adolescents; and most of the described series include small number of subjects. Hence study was conducted to evaluate the etiology, clinical presentation of chronic pancreatitis in children. The age group of the patients are upto 18 years. The patients astroenterology department of hospital in North India were considered in the study. All the patient’s clinical history were collected. Also the complete physical examination was done. Idiopathic chronic pancreatitis is the principal type of chronic pancreatitis in children and adolescents. It can present with or without calcification. The calcific variety is an aggressive disease characterized by early morphological and functional damage to the pancreas
{"title":"Clinical Profile and Outcome of Chronic Pancreatitis in Children","authors":"D. Singh","doi":"10.15272/ajbps.v6i57.840","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.840","url":null,"abstract":"Chronic pancreatitis (CP) is characterised by pancreatic inflammation and fibrosis the endpoint of which is destruction of pancreatic parenchyma with eventual loss of exocrine and endocrine function. Yet the syndrome is well considered in adults, there is incomplete data in children and adolescents; and most of the described series include small number of subjects. Hence study was conducted to evaluate the etiology, clinical presentation of chronic pancreatitis in children. The age group of the patients are upto 18 years. The patients astroenterology department of hospital in North India were considered in the study. All the patient’s clinical history were collected. Also the complete physical examination was done. Idiopathic chronic pancreatitis is the principal type of chronic pancreatitis in children and adolescents. It can present with or without calcification. The calcific variety is an aggressive disease characterized by early morphological and functional damage to the pancreas","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"79 1","pages":"45-47"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76502335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-07DOI: 10.15272/AJBPS.V6I57.839
A. Singh
The cystic swellings of scrotum are one among the common surgical problem in all age group. Objective of this study is to identify the cause, mode of presentation, various modalities of management and outcome of these with least complications. A total of 30 cases of cystic swellings of scrotum fulfilling the methodology criteria were subjected to preformatted study. Final diagnosis was made with clinical examination and ultrasound. All 50 cases were treated surgically. Most of the patients were in age group of 31-40 years, common presenting feature being scrotal swelling. Primary vaginal hydrocele was the commonest cystic swelling followed by epididymal cyst, sebaceous cyst, haematocoele, pyocoele. Most of the patients were discharged around 8th Post-operative day. All of the cystic swellings were treated surgically with good results.
{"title":"Clinico pathological Study of Cystic Swellings of Scrotum","authors":"A. Singh","doi":"10.15272/AJBPS.V6I57.839","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.839","url":null,"abstract":"The cystic swellings of scrotum are one among the common surgical problem in all age group. Objective of this study is to identify the cause, mode of presentation, various modalities of management and outcome of these with least complications. A total of 30 cases of cystic swellings of scrotum fulfilling the methodology criteria were subjected to preformatted study. Final diagnosis was made with clinical examination and ultrasound. All 50 cases were treated surgically. Most of the patients were in age group of 31-40 years, common presenting feature being scrotal swelling. Primary vaginal hydrocele was the commonest cystic swelling followed by epididymal cyst, sebaceous cyst, haematocoele, pyocoele. Most of the patients were discharged around 8th Post-operative day. All of the cystic swellings were treated surgically with good results.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"9 1","pages":"42-44"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78640246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-07DOI: 10.15272/AJBPS.V6I57.838
D. Singh
Abdominal tuberculosis is defined as infection of the peritoneum, hollow or solid abdominal organs with Mycobacterium tuberculi. The peritoneum and the ileocaecal region are the most likely sites of infection and are involved in the majority of the cases by hematogenous spread or through swallowing of infected sputum from primary pulmonary tuberculosis.The 40 patients were enrolled in to the study. The age group of the patients are from 20-50 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All patients, where diagnosis of tuberculosis was confirmed, received three-drug anti-tubercular regimen. There was no post-operative mortality. Inspite of specific anti tuberculosis drugs and vast measures against the disease, including chemoprophylaxis and pasteurisation abdominal tuberculosis remains a fairly common disease even today. Young adults between 20-40 years are the most commonly affected.
{"title":"A Study of Abdominal tuberculosis in North Indian Patients","authors":"D. Singh","doi":"10.15272/AJBPS.V6I57.838","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I57.838","url":null,"abstract":"Abdominal tuberculosis is defined as infection of the peritoneum, hollow or solid abdominal organs with Mycobacterium tuberculi. The peritoneum and the ileocaecal region are the most likely sites of infection and are involved in the majority of the cases by hematogenous spread or through swallowing of infected sputum from primary pulmonary tuberculosis.The 40 patients were enrolled in to the study. The age group of the patients are from 20-50 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All patients, where diagnosis of tuberculosis was confirmed, received three-drug anti-tubercular regimen. There was no post-operative mortality. Inspite of specific anti tuberculosis drugs and vast measures against the disease, including chemoprophylaxis and pasteurisation abdominal tuberculosis remains a fairly common disease even today. Young adults between 20-40 years are the most commonly affected.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"1 1","pages":"40-41"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85273999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-19DOI: 10.15272/ajbps.v6i54.789
S. Balasubramanian, V. R. and
Herbal medicines are respected for its medicinal values through generations. Areca catechu is commonly called as betel nut belonging to the family Arecaceae. Phytochemicals are the non-nutritive substances that protect the plant and human beings from diseases when consumed. In the present investigation, the aqueous extract of Areca catechu nut was analysed for the varieties of phytochemicals and the total tannin content was also quantified. The presence of saponin, flavonoid, tannin, phenol, steroid, alkaloid and protein were recorded in the aqueous extract of Areca catechu nut whereas acid and triterpenoid recorded their absence. Total tannin content was found to be 95.3 mg TE/g. Hence, it is proposed that Areca catechu nut may possess medicinal properties against human diseases.
{"title":"Phytochemical Qualitative Analysis and Total Tannin Content in the Aqueous Extract of Areca catechu Nut","authors":"S. Balasubramanian, V. R. and","doi":"10.15272/ajbps.v6i54.789","DOIUrl":"https://doi.org/10.15272/ajbps.v6i54.789","url":null,"abstract":"Herbal medicines are respected for its medicinal values through generations. Areca catechu is commonly called as betel nut belonging to the family Arecaceae. Phytochemicals are the non-nutritive substances that protect the plant and human beings from diseases when consumed. In the present investigation, the aqueous extract of Areca catechu nut was analysed for the varieties of phytochemicals and the total tannin content was also quantified. The presence of saponin, flavonoid, tannin, phenol, steroid, alkaloid and protein were recorded in the aqueous extract of Areca catechu nut whereas acid and triterpenoid recorded their absence. Total tannin content was found to be 95.3 mg TE/g. Hence, it is proposed that Areca catechu nut may possess medicinal properties against human diseases.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"179 1","pages":"07-09"},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83760621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-19DOI: 10.15272/AJBPS.V6I54.801
P. Ck, E. Jc
Gestational hypertension, also referred to as pregnancy induced hypertension (PIH) is a condition characterized by high blood pressure during pregnancy. Gestational hypertension can lead to a serious condition called preeclampsia, also referred to as toxemia. Hypertension during pregnancy affects about 6-8% of pregnant women. The present study was conducted in the Hospital in the North India. A total 80 women’s were included in the study. 40 normal condition and 40 pregnant womens having hypertension were included in to the study. The blood samples were collected and the estimation of blood urea, serum creatinine, Cholesterol, triglyceride, HDL, LDL, & VLDL is done. The present study showed the changes in the lipid parameters in the pregnancy induced hypertension womens and normal pregnant womens. The levels of the Proteinuria, Blood urea, Serum creatinine were estimated as the function of the kidney function test. The lipid parameters were also estimated and showed marked changes in the two study groups. Hence the monitoring of the lipid parameters in PIH womens is important to avoid any complications.
{"title":"Assessment of Lipoproteins in Pregnancy Induced Hypertension","authors":"P. Ck, E. Jc","doi":"10.15272/AJBPS.V6I54.801","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I54.801","url":null,"abstract":"Gestational hypertension, also referred to as pregnancy induced hypertension (PIH) is a condition characterized by high blood pressure during pregnancy. Gestational hypertension can lead to a serious condition called preeclampsia, also referred to as toxemia. Hypertension during pregnancy affects about 6-8% of pregnant women. The present study was conducted in the Hospital in the North India. A total 80 women’s were included in the study. 40 normal condition and 40 pregnant womens having hypertension were included in to the study. The blood samples were collected and the estimation of blood urea, serum creatinine, Cholesterol, triglyceride, HDL, LDL, & VLDL is done. The present study showed the changes in the lipid parameters in the pregnancy induced hypertension womens and normal pregnant womens. The levels of the Proteinuria, Blood urea, Serum creatinine were estimated as the function of the kidney function test. The lipid parameters were also estimated and showed marked changes in the two study groups. Hence the monitoring of the lipid parameters in PIH womens is important to avoid any complications.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"24 1","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81490349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-19DOI: 10.15272/AJBPS.V6I54.785
Mireille Km, P. Dd, Bilanda Danielle Claude, Yol, rine Mn, M. Marguerite, Ngoungoure Madeleine Chantal, N. Rodrigue, Agnes Oc, D. Théophile, Kamtchouing Pierre
Stress has been associated with various diseases such as harms the heart system, nervous system, affect the level of hormone, but also morphology and function of testis. The purpose of the present study was to investigate protective properties of Nymphaea lotus (N. lotus), against deleterious effects induced by unpredictable chronic mild stress (CMS) on testes of albino male rats. Adult male Wistar rats were divided into five groups as one non-stressed group and four stressed groups (n = 5 in each group). The stressed groups were exposed to 14 days of CMS, receiving concomitantly and respectively, distilled water (10 mL/kg), Yohimbine (2 mg/kg) and N. lotus at the level of 75 and 200 mg/kg. The reproductive organs weight, oxidative stress markers, and histoarchitecture of the testis were examined. Exposition to CMS to the male rats caused no significant changes in the relative weight of testis, but affects its histoarchitecture, that is preserved in stressed rats treated with N. lotus. Further CMS significantly declined the amount of Nitrites (P<0.05), GSH (P<0.05) and SOD (P<0.001) levels and increase up to 16.25% the level of testicular lipid peroxidation when compared to unstressed rats. N. lotus at the both doses significantly reduced (P<0.001 for 75 mg/kg and P<0.01 for 200 mg/kg) MDA levels in comparison to stressed rats, suggesting an lipid peroxidation inhibitory effect of our plant. The unpredictable chronic mild stress paradigm used in our study enhanced oxidative stress in testis and causes histological damages that N. lotus treatment significantly minimize.
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