Pub Date : 2016-05-31DOI: 10.15272/AJBPS.V6I56.814
Chavan Bb, Gadekar As, Mehta Pp, P. Vawhal, Kolsure Ak, Chabukswar Ar
Chalcone is an aromatic ketone that forms a central core for a variety of important biological compounds, which are collectively known as chalcones. They possess different activities like antibacterial, antifungal, anti-inflammatory and anti tumor etc depending on the substitution made on them. Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon α, β-unsaturated carbonyl system.These are abundant in edible plants and are considered to be precursors of flavonoids and isoflavonoids. Chalcones possess conjugated double bonds and a completely delocalized Π-electron system on both benzene rings. Molecules possessing such system have relatively low redox potentials and have a greater probability of undergoing electron transfer reactions. The compounds with the backbone of chalcones have been reported to possess various biological activities such as antimicrobial, anti-inflammatory, analgesic, anti platelet, anti ulcerative, anti malarial, anticancer, antiviral, anti leishmanial, antioxidant, anti tubercular, anti hyperglycemic, immunomodulatory, inhibition of chemical mediators release, inhibition of leukotriene B4, inhibition of tyrosinase and inhibition of aldose reductase activities. The presence of a reactive alpha, beta -unsatutated keto function in chalcones is found to be responsible for their antimicrobial activity. In this paper through reviewing different biological significance of chalcones and their derivatives have been reported along with their chemistry and of synthesis. Synthetically or chemically chalcones are synthesized by two reactions: a) Aldol condensation and b) Claisen Schmidt condensation. But here is a focus on chalcones synthesized by Claisen Schmidt condensation which involves the condensation between an aromatic aldehyde or ketone with an aliphatic ketone or aldehyde catalysed by the presence of dilute alkali or acid to form alpha beta unsaturated compound.
{"title":"Synthesis and Medicinal Significance of Chalcones- A Review","authors":"Chavan Bb, Gadekar As, Mehta Pp, P. Vawhal, Kolsure Ak, Chabukswar Ar","doi":"10.15272/AJBPS.V6I56.814","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I56.814","url":null,"abstract":"Chalcone is an aromatic ketone that forms a central core for a variety of important biological compounds, which are collectively known as chalcones. They possess different activities like antibacterial, antifungal, anti-inflammatory and anti tumor etc depending on the substitution made on them. Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon α, β-unsaturated carbonyl system.These are abundant in edible plants and are considered to be precursors of flavonoids and isoflavonoids. Chalcones possess conjugated double bonds and a completely delocalized Π-electron system on both benzene rings. Molecules possessing such system have relatively low redox potentials and have a greater probability of undergoing electron transfer reactions. The compounds with the backbone of chalcones have been reported to possess various biological activities such as antimicrobial, anti-inflammatory, analgesic, anti platelet, anti ulcerative, anti malarial, anticancer, antiviral, anti leishmanial, antioxidant, anti tubercular, anti hyperglycemic, immunomodulatory, inhibition of chemical mediators release, inhibition of leukotriene B4, inhibition of tyrosinase and inhibition of aldose reductase activities. The presence of a reactive alpha, beta -unsatutated keto function in chalcones is found to be responsible for their antimicrobial activity. In this paper through reviewing different biological significance of chalcones and their derivatives have been reported along with their chemistry and of synthesis. Synthetically or chemically chalcones are synthesized by two reactions: a) Aldol condensation and b) Claisen Schmidt condensation. But here is a focus on chalcones synthesized by Claisen Schmidt condensation which involves the condensation between an aromatic aldehyde or ketone with an aliphatic ketone or aldehyde catalysed by the presence of dilute alkali or acid to form alpha beta unsaturated compound.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"19 1","pages":"01-07"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85147817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-31DOI: 10.15272/AJBPS.V6I56.813
H. Zeweil, Abaza Im, S. Zahran, M. Ahmed, M. Haiam, Asmaa As
This work was performed to investigate the effect of Spirulina platensis levels and vitamin E under heat stress on the performance, some physiological and blood biochemical constituents, antioxidant and immune responses traits of growing chickens. A total of 150 male Gimmizah local strain chicks (4 weeks of age) were randomly distributed among five treatment groups in battery brooder placed in a temperature-controlled room until 14 weeks of age. The first treatment was fed the basal diet only without any supplementation and kept in the first sector under optimum temperature 22-24oC and relative humidity (RH) 45-55 % (normal) used as negative control. Whereas, the other four treatments were kept in the last sector under chronic heat stress condition (38°C±1; 55-65 % RH) for three successive days a week from 11.00 am until 15.00 pm. The first heat stress group was fed the basal diet only without any supplementation and used as positive control (PC). Whereas in the other three treatments were fed the basal diet supplemented with Spirulina platensis at levels (0.5 and 1 g/kg diet) and vitamin E (75 mg/kg diet). The results indicated that different supplementations as Spirulina and VE decreased adverse effect of heat stress on growth performance and blood total protein, albumin, globulin, createinin, ALT, AST, total lipids, LDL, WBCs, RBCs, immunity of Chickens. In conclusion, addition of Spirulina platensis improved growth performance, immunity and can be decreased adverse effect stress on chickens under heat stress condition.
{"title":"Effect of Spirulina platensis as dietary Supplement on Some Biological Traits for Chickensunder Heat Stress Condition","authors":"H. Zeweil, Abaza Im, S. Zahran, M. Ahmed, M. Haiam, Asmaa As","doi":"10.15272/AJBPS.V6I56.813","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I56.813","url":null,"abstract":"This work was performed to investigate the effect of Spirulina platensis levels and vitamin E under heat stress on the performance, some physiological and blood biochemical constituents, antioxidant and immune responses traits of growing chickens. A total of 150 male Gimmizah local strain chicks (4 weeks of age) were randomly distributed among five treatment groups in battery brooder placed in a temperature-controlled room until 14 weeks of age. The first treatment was fed the basal diet only without any supplementation and kept in the first sector under optimum temperature 22-24oC and relative humidity (RH) 45-55 % (normal) used as negative control. Whereas, the other four treatments were kept in the last sector under chronic heat stress condition (38°C±1; 55-65 % RH) for three successive days a week from 11.00 am until 15.00 pm. The first heat stress group was fed the basal diet only without any supplementation and used as positive control (PC). Whereas in the other three treatments were fed the basal diet supplemented with Spirulina platensis at levels (0.5 and 1 g/kg diet) and vitamin E (75 mg/kg diet). The results indicated that different supplementations as Spirulina and VE decreased adverse effect of heat stress on growth performance and blood total protein, albumin, globulin, createinin, ALT, AST, total lipids, LDL, WBCs, RBCs, immunity of Chickens. In conclusion, addition of Spirulina platensis improved growth performance, immunity and can be decreased adverse effect stress on chickens under heat stress condition.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"43 1","pages":"08-12"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89634871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-31DOI: 10.15272/ajbps.v6i56.817
Hossein Eslami, A. Zarandi, F. Pouralibaba, Vahid Fakhrzadeh, Parisa Falsafi, Roya Rezaii Sepas
Streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of cytokines in dental caries. The aim of this study was to evaluate TGF-β in patients with S. mutans.Seventy samples were selected during pulpectomy and investigated for the presence of TGF-β by ELISA. The results were analyzed by t-test (α = 0.05). The results showed higher mean concentrations of TGF-β in inflamed pulpal tissues in subjects with dental caries associated with S. mutans, compared with intact pulpal tissue samples; these higher means were statistically significant in all cases (P < 0.05). The results of this study suggested relations between the production of TGF-β in dental caries caused by S. mutans .
{"title":"Assessment of Relationship between Streptococcus mutans, Dental Caries and TGF-β","authors":"Hossein Eslami, A. Zarandi, F. Pouralibaba, Vahid Fakhrzadeh, Parisa Falsafi, Roya Rezaii Sepas","doi":"10.15272/ajbps.v6i56.817","DOIUrl":"https://doi.org/10.15272/ajbps.v6i56.817","url":null,"abstract":"Streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of cytokines in dental caries. The aim of this study was to evaluate TGF-β in patients with S. mutans.Seventy samples were selected during pulpectomy and investigated for the presence of TGF-β by ELISA. The results were analyzed by t-test (α = 0.05). The results showed higher mean concentrations of TGF-β in inflamed pulpal tissues in subjects with dental caries associated with S. mutans, compared with intact pulpal tissue samples; these higher means were statistically significant in all cases (P < 0.05). The results of this study suggested relations between the production of TGF-β in dental caries caused by S. mutans .","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"10 5 1","pages":"20-22"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82710262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-07DOI: 10.15272/ajbps.v6i57.843
Kalyani Singh
Vaginal bleeding during the first trimester has been estimated to occur in 16% of all pregnant women, while the frequency of spontaneous abortion is traditionally estimated as 10-20%. The clinical approach though helpful is of limited value. Despite the latest technological developments and laboratory diagnosis the desired goal of early recognition is not achieved.The objective of the study to evaluate role of ultrasound in patients with first trimester vaginal bleeding. Hospital based study. A total of 100 cases presented with complaint of bleeding per vaginum during first trimester, were enrolled for study. Ultrasonographic examinations were done per abdominally by using ultrasound equipment.The data showed that it is the common problem in 20-30 age pregnant womens. In the present study various types of abortions constituted the commonest cause of first trimester bleeding. All cases the cases were diagnosed correctly on ultrasonography with 100% sensitivity and accuracy and managed appropriately. So ultrasound helped in establishing correct diagnosis timey and decides the line of management. Keywords: First trimester bleeding, Ultrasound examination, Clinical examination, Vaginal bleeding.
{"title":"Assessment of First Trimester Vaginal Bleeding Using Ultrasound Sonography","authors":"Kalyani Singh","doi":"10.15272/ajbps.v6i57.843","DOIUrl":"https://doi.org/10.15272/ajbps.v6i57.843","url":null,"abstract":"Vaginal bleeding during the first trimester has been estimated to occur in 16% of all pregnant women, while the frequency of spontaneous abortion is traditionally estimated as 10-20%. The clinical approach though helpful is of limited value. Despite the latest technological developments and laboratory diagnosis the desired goal of early recognition is not achieved.The objective of the study to evaluate role of ultrasound in patients with first trimester vaginal bleeding. Hospital based study. A total of 100 cases presented with complaint of bleeding per vaginum during first trimester, were enrolled for study. Ultrasonographic examinations were done per abdominally by using ultrasound equipment.The data showed that it is the common problem in 20-30 age pregnant womens. In the present study various types of abortions constituted the commonest cause of first trimester bleeding. All cases the cases were diagnosed correctly on ultrasonography with 100% sensitivity and accuracy and managed appropriately. So ultrasound helped in establishing correct diagnosis timey and decides the line of management. Keywords: First trimester bleeding, Ultrasound examination, Clinical examination, Vaginal bleeding.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"120 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2016-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77305007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-03DOI: 10.15272/AJBPS.V6I53.794
R. Kumari
Goiter is denotes to the abnormal development of the thyroid gland. The insufficient intake of the Iodine may lead to the Goiter. Iodine deficiency is a lack of the trace element iodine. It may result in goiter (so-called endemic goiter), as well as cretinism, which results in developmental delays and other health problems. Iodine deficiency is an important public health issue as it is a preventable cause of intellectual disability. The goiter survey was done in the rural area of the North Indian district. In the study the primary schools were selected to get the proposed goiter population for the study. The school children’s between the age of 5-12 years were included from the schools. All the enrolled patients were clinically examined for the goiter i.e. development of the thyroid. The age & the sex of the students were also noted. In the summary that the present data showed that the prevalence of the goiter in the age group of the 5-13 in the rural area of the north India. There is need to implement the ban on the non iodized salt in the area. Also the efforts must be taken to improve awareness regarding the use of Iodized salt to avoid the Goiter.
{"title":"Goiter Prevalence in Children in North India Region","authors":"R. Kumari","doi":"10.15272/AJBPS.V6I53.794","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I53.794","url":null,"abstract":"Goiter is denotes to the abnormal development of the thyroid gland. The insufficient intake of the Iodine may lead to the Goiter. Iodine deficiency is a lack of the trace element iodine. It may result in goiter (so-called endemic goiter), as well as cretinism, which results in developmental delays and other health problems. Iodine deficiency is an important public health issue as it is a preventable cause of intellectual disability. The goiter survey was done in the rural area of the North Indian district. In the study the primary schools were selected to get the proposed goiter population for the study. The school children’s between the age of 5-12 years were included from the schools. All the enrolled patients were clinically examined for the goiter i.e. development of the thyroid. The age & the sex of the students were also noted. In the summary that the present data showed that the prevalence of the goiter in the age group of the 5-13 in the rural area of the north India. There is need to implement the ban on the non iodized salt in the area. Also the efforts must be taken to improve awareness regarding the use of Iodized salt to avoid the Goiter.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"2 1","pages":"39-40"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83598644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-03DOI: 10.15272/AJBPS.V6I53.791
P. Ck, E. Jc
In the Cirrhosis healthy liver tissue is changed with scar tissue. The blood flow is affected through the liver. This is responsible for the decrease circulation of nutrients, hormones, drugs, and naturally produced toxins. Zinc is a micronutrient that plays an important role in the function of liver. Significant decrease in zinc levels were observed in liver cirrhosis patients. The study was conducted in 30 liver cirrhotic patients. The blood samples were obtained from the patients. The samples were then sent to the pathological findings of zinc. The zinc estimation was done using Atomic Absorption Spectrophotometer. The revealed that there is lower the zinc level in the liver cirrohotic patients. This work is an attempt to understand the important role that the zinc plays in the pathogenesis and therapy of liver cirrhosis.
{"title":"Monitoring of Zinc in Liver Cirrhosis Patients","authors":"P. Ck, E. Jc","doi":"10.15272/AJBPS.V6I53.791","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I53.791","url":null,"abstract":"In the Cirrhosis healthy liver tissue is changed with scar tissue. The blood flow is affected through the liver. This is responsible for the decrease circulation of nutrients, hormones, drugs, and naturally produced toxins. Zinc is a micronutrient that plays an important role in the function of liver. Significant decrease in zinc levels were observed in liver cirrhosis patients. The study was conducted in 30 liver cirrhotic patients. The blood samples were obtained from the patients. The samples were then sent to the pathological findings of zinc. The zinc estimation was done using Atomic Absorption Spectrophotometer. The revealed that there is lower the zinc level in the liver cirrohotic patients. This work is an attempt to understand the important role that the zinc plays in the pathogenesis and therapy of liver cirrhosis.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"14 1","pages":"32-34"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87679060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-03DOI: 10.15272/AJBPS.V6I53.793
R. Kumari
Blindness is a worldwide problem. Corneal blindness accounts for 0.9%of blindness in India. Approximately 0.12 million people are corneal blind. Restoration of their vision is possible only through transplantation. Though 45000 eyes are collected every year, it does not meet half the requirement. Well informed medical students could be expected to enhance eye donation rates. To study the awareness of the patient about the eye donation is assessed. This cross-sectional type of study was conducted in 200 Life sciences students. All the required information was collected on pretested, semi-structured questionnaire. All the students know that eye can be donated. 170 students tell that there is no age limit for eye donation. ‘Eyes can be removed from living peoples’ this answer is told by 185 students. 155 students told that consent of family is not required for the pledging. 170 students told that there is shortage of donors in India. The results of the study indicate that although awareness regarding eye donation is high, there is lack of motivation related to eye donation.
{"title":"Eye Donation Awareness among the Students","authors":"R. Kumari","doi":"10.15272/AJBPS.V6I53.793","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I53.793","url":null,"abstract":"Blindness is a worldwide problem. Corneal blindness accounts for 0.9%of blindness in India. Approximately 0.12 million people are corneal blind. Restoration of their vision is possible only through transplantation. Though 45000 eyes are collected every year, it does not meet half the requirement. Well informed medical students could be expected to enhance eye donation rates. To study the awareness of the patient about the eye donation is assessed. This cross-sectional type of study was conducted in 200 Life sciences students. All the required information was collected on pretested, semi-structured questionnaire. All the students know that eye can be donated. 170 students tell that there is no age limit for eye donation. ‘Eyes can be removed from living peoples’ this answer is told by 185 students. 155 students told that consent of family is not required for the pledging. 170 students told that there is shortage of donors in India. The results of the study indicate that although awareness regarding eye donation is high, there is lack of motivation related to eye donation.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"27 1","pages":"37-38"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73163548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-03DOI: 10.15272/AJBPS.V6I53.792
ey Cj, P. Ck
Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. Hence the present study was conducted to evaluate the levels of the acute phase proteins in the normal healthy group & the liver diseases patient. The 40 liver diseases patients were enrolled in to the study. All the patients are informed consents. The liver diseases include the liver cirrohosis, jaundice, infective hepatitis. The age group of the patients are from 20-50 years. 20 normal healthy groups were also selected as control to study the levels of acute phase proteins in them. Ceruloplasmin and Serum transferrin is estimated from the pathological findings. From the above study it can be concluded that the acute phase proteins in liver disorders plays important role. The increases level of the ceruloplasmin and transferrin shows the liver disorders.
{"title":"Study of acute phase proteins in liver disease","authors":"ey Cj, P. Ck","doi":"10.15272/AJBPS.V6I53.792","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I53.792","url":null,"abstract":"Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. Hence the present study was conducted to evaluate the levels of the acute phase proteins in the normal healthy group & the liver diseases patient. The 40 liver diseases patients were enrolled in to the study. All the patients are informed consents. The liver diseases include the liver cirrohosis, jaundice, infective hepatitis. The age group of the patients are from 20-50 years. 20 normal healthy groups were also selected as control to study the levels of acute phase proteins in them. Ceruloplasmin and Serum transferrin is estimated from the pathological findings. From the above study it can be concluded that the acute phase proteins in liver disorders plays important role. The increases level of the ceruloplasmin and transferrin shows the liver disorders.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"20 1","pages":"35-36"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90330675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-30DOI: 10.15272/ajbps.v6i55.811
A. Marwah
Objective: To study the profile of gross congenital malformations among live newborns and its associated risk factors. Material and methods: All the babies born in this hospital (live births) during January 2014 to December 2014 formed the baseline population and those with congenital malformations were included in the study. Antenatal records were assessed and mothers were interviewed for socio-demographic variables. Study design: Cross- sectional, descriptive. Results: There were 6143 live births out of which 109 had gross congenital malformations giving an incidence of 1.7%. Central nervous system was most commonly affected (48%) followed by musculoskeletal (28%) and gastrointestinal system (13%). Incidence of congenital malformations was more among multipara females, preterm and low birth weight babies. Conclusion: A relative increase in the incidence of congenital malformations once again implies the importance of public health education and regular antenatal screening. We also, strongly recommend mandatory screening of all newborns by pediatrician after birth for timely detection and best possible treatment of these congenital malformations. Keywords: congenital malformation, newborn, live birth, antenatal, genetic.
{"title":"Profile of gross congenital malformations among live newborns and its associated risk factors from a tertiary care rural teaching institute.","authors":"A. Marwah","doi":"10.15272/ajbps.v6i55.811","DOIUrl":"https://doi.org/10.15272/ajbps.v6i55.811","url":null,"abstract":"Objective: To study the profile of gross congenital malformations among live newborns and its associated risk factors. Material and methods: All the babies born in this hospital (live births) during January 2014 to December 2014 formed the baseline population and those with congenital malformations were included in the study. Antenatal records were assessed and mothers were interviewed for socio-demographic variables. Study design: Cross- sectional, descriptive. Results: There were 6143 live births out of which 109 had gross congenital malformations giving an incidence of 1.7%. Central nervous system was most commonly affected (48%) followed by musculoskeletal (28%) and gastrointestinal system (13%). Incidence of congenital malformations was more among multipara females, preterm and low birth weight babies. Conclusion: A relative increase in the incidence of congenital malformations once again implies the importance of public health education and regular antenatal screening. We also, strongly recommend mandatory screening of all newborns by pediatrician after birth for timely detection and best possible treatment of these congenital malformations. Keywords: congenital malformation, newborn, live birth, antenatal, genetic.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"4 1","pages":"16-18"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78442707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-04-25DOI: 10.15272/AJBPS.V6I55.809
K. Dhanya, S. Satish, K. Hegde, A. Shabaraya
Two doses (100 mg/kg and 200 mg/kg p.o) of the Albizia julibrissin essential oil (AJEO) were subjected for the evaluation of learning and memory enhancing activity against amnesia induced by scopolamine (0.4mg/kg, i.p) in young mice. Piracetam (400 mg/kg i.p) was served as standard in both the models. Biochemical parameter like Anticholinesterase activity was evaluated. Both the lower (100mg/kg) and higher dose (200mg/kg) of AJEO has shown dose dependent significant decrease in Transfer latency (TL) by EPM and decrease in AChE activity in brain estimation which in terms indicate improved learning and memory when compared with scopolamine group. Sub-acute treatment (long term) was more significant than acute treatment (short term) on learning and memory enhancing activity.
{"title":"Investigation on Learning and Memory Enhancing activity of Essential Oil inAlbizia julibrissin Flowers in Experimental Mice","authors":"K. Dhanya, S. Satish, K. Hegde, A. Shabaraya","doi":"10.15272/AJBPS.V6I55.809","DOIUrl":"https://doi.org/10.15272/AJBPS.V6I55.809","url":null,"abstract":"Two doses (100 mg/kg and 200 mg/kg p.o) of the Albizia julibrissin essential oil (AJEO) were subjected for the evaluation of learning and memory enhancing activity against amnesia induced by scopolamine (0.4mg/kg, i.p) in young mice. Piracetam (400 mg/kg i.p) was served as standard in both the models. Biochemical parameter like Anticholinesterase activity was evaluated. Both the lower (100mg/kg) and higher dose (200mg/kg) of AJEO has shown dose dependent significant decrease in Transfer latency (TL) by EPM and decrease in AChE activity in brain estimation which in terms indicate improved learning and memory when compared with scopolamine group. Sub-acute treatment (long term) was more significant than acute treatment (short term) on learning and memory enhancing activity.","PeriodicalId":8517,"journal":{"name":"Asian Journal of Biomedical and Pharmaceutical Sciences","volume":"6 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87159241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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