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Antidepressant, Antidiarrheal, Thrombolytic and Phytochemical Profiling of Ethanol Extract of Amomum aromaticum Leaves: In vivo and In vitro Approaches 香叶乙醇提取物的抗抑郁、止泻、溶栓和植物化学分析:体内和体外方法
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71152
Enama Nabi Shetu, M. Sayeed, Mohammad Arman, M. Maruf, S. Sayem, M. Islam
The study evaluated several pharmacological effects including antidepressant, antidiarrheal and thrombolytic activities of ethanol extract of Amomum aromaticum leaves (EEAA). Upon the assessment for qualitative phytochemical groups in the extract, several doses of EEAA (1000 - 4000 mg/kg) were studied to find acute oral toxicity in mouse for safe dose selection. Then EEAA was tested whether it demonstrates antidepressant activity in tail suspension test (TST) and forced swim test (FST). Antidiarrheal and clot lysis activities of EEAA were evaluated in castor oil-induced diarrhoea in mouse and In vitro clot lysis method, respectively. Oral administration of EEAA (1000 - 4000 mg/kg) showed no morality after 10 days, and no sign of acute toxicity observed within 24 hrs post-treatment. The qualitative phytochemical screening showed the presence of carbohydrate, alkaloid, flavonoid, tannin, saponin, and polyphenol groups in EEAA. The TST and FST resulted with significant improvement in mobility in mice treated with EEAA (400 mg/kg), where fluoxetine (20 mg/kg) was used as standard in both tests. EEAA treatment also showed a moderate dose-dependent anti-diarrheal effect. The 400 mg/kg oral dosing for 14 days decreased the rate of defecation by 52.8% compared to the control group. This study also demonstrated that EEAA possesses clot lysis activity. Hence, further intense investigations are suggested to identify specific potential active phytochemicals.Bangladesh Pharmaceutical Journal 27(1): 51-58, 2024 (January)
该研究评估了芳香树叶乙醇提取物(EEAA)的多种药理作用,包括抗抑郁、止泻和溶栓活性。在对提取物中的植物化学组进行定性评估后,研究了几种剂量的 EEAA(1000 - 4000 mg/kg),以发现小鼠急性经口毒性,从而选择安全剂量。然后测试了 EEAA 在尾悬试验(TST)和强迫游泳试验(FST)中是否具有抗抑郁活性。在蓖麻油诱导的小鼠腹泻和体外凝块溶解法中,分别评估了 EEAA 的止泻和凝块溶解活性。口服 EEAA(1000 - 4000 毫克/千克)10 天后,小鼠无腹泻症状,且在治疗后 24 小时内未观察到急性毒性迹象。植物化学定性筛选显示,EEAA 中含有碳水化合物、生物碱、黄酮类、单宁、皂苷和多酚类。在以氟西汀(20 毫克/千克)为标准的两项测试中,用 EEAA(400 毫克/千克)治疗小鼠后,TST 和 FST 均显著改善了小鼠的活动能力。EEAA 还显示出中等剂量依赖性的止泻效果。与对照组相比,连续 14 天口服 400 毫克/千克可使排便率降低 52.8%。这项研究还表明,EEAA 具有凝块溶解活性。因此,建议进一步深入研究,以确定特定的潜在活性植物化学物质:51-58,2024 年(一月)
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引用次数: 0
Characterization and In vitro Dissolution Assessment of Pitavastatin-polyvinyl Pyrrolidone and Kollicoat®IR Solid Dispersions Prepared by Solvent Evaporation and Fusion Methodologies 用溶剂蒸发法和熔融法制备的匹伐他汀-聚乙烯吡咯烷酮和 Kollicoat®IR 固体分散体的特性和体外溶出度评估
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71151
Ishtyaque Mikrani, Kazi Milenur Rahman Prattay, Md Raihan Sarkar, K. Sikdar, Mashiur Rahman, Md Abdus Samadd
Pitavastatin (PTV) is a potent lipid lowering drug that acts on hepatocytes by blocking the 3-hydroxy-3- methylglutaryl-CoA reductase enzyme. As a Biopharmaceutical Classification System (BCS) Class II drug, PTV possesses very low water solubility; hence, poor bioavailability leads to poor drug delivery to the target organ. The study aims to develop various PTV solid dispersion (SD) formulations and to investigate the release profile of PTV SD systems. Different PTV physical mixing and SD formulations were prepared using polyvinylpyrrolidone (Kollidon®90F) and Kollicoat®IR hydrophilic polymers by fusion and solvent evaporation approaches. The efficacy of the formulations was evaluated by in vitro PTV release studies. Subsequently, the characterization of SD formulations was performed using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The in vitro release studies confirmed that all the developed formulations showed a comparatively better release percentage (75.31–98.45%) than the pure PTV (61.76%) after 60 min. Additionally, the outcomes showed that raising the concentration of both polymers improved PTV's ability to dissolve. In comparison to physical mixing formulations, SD formulations made using fusion and solvent evaporation processes performed better during dissolution. The TGA, DSC, and FTIR studies confirmed that the tested SD formulations (1:2, 1:3 ratios) were stable at high temperatures with a reduction in crystallinity and no notable interaction between the drug and polymers. The SEM analysis showed that the PTV was evenly spread out in the carriers and that the crystal-like structure of the PTV had changed into an amorphous form.Bangladesh Pharmaceutical Journal 27(1): 37-50, 2024 (January)
匹伐他汀(PTV)是一种强效降脂药,通过阻断 3-hydroxy-3- methylglutaryl-CoA 还原酶作用于肝细胞。作为生物制药分类系统(BCS)的二类药物,PTV 的水溶性非常低,因此生物利用度较低,导致药物难以输送到靶器官。本研究旨在开发各种 PTV 固体分散(SD)制剂,并研究 PTV SD 系统的释放曲线。研究人员使用聚乙烯吡咯烷酮(Kollidon®90F)和 Kollicoat®IR 亲水聚合物,通过熔融和溶剂蒸发方法制备了不同的 PTV 物理混合和 SD 制剂。通过体外 PTV 释放研究评估了制剂的功效。随后,使用热重分析法(TGA)、差示扫描量热法(DSC)、傅立叶变换红外光谱法(FTIR)和扫描电子显微镜法(SEM)对 SD 制剂进行了表征。体外释放研究证实,与纯 PTV(61.76%)相比,所有开发的制剂在 60 分钟后的释放率(75.31%-98.45%)都相对较高。此外,研究结果表明,提高两种聚合物的浓度可提高 PTV 的溶解能力。与物理混合配方相比,使用熔融和溶剂蒸发工艺制作的 SD 配方在溶解过程中表现更好。TGA、DSC 和 FTIR 研究证实,测试的 SD 制剂(1:2、1:3 比例)在高温下稳定,结晶度降低,药物和聚合物之间没有明显的相互作用。扫描电镜分析表明,PTV 在载体中均匀分布,PTV 的晶体结构已变为无定形形式:37-50,2024 年(1 月)
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引用次数: 0
In vitro Anti-inflammatory, Antioxidant and Membrane Stabilization Activities of Leaf Extracts of Byttneria pilosa Roxb Byttneria pilosa Roxb 叶提取物的体外抗炎、抗氧化和膜稳定活性
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71161
Bilkis Zohora, A. Faruq, M. Adib, Irin Sultana, M. Chowdhury
This current research work was conducted an investigation into the biological activities of various fractions of Byttneria pilosa Roxb. (Family: Sterculiaceae) and analyze the chemical compositions. Preliminary examination of the raw fractional extractives identified the presence of alkaloids, glycosides, flavonoids, saponins, reducing sugars, and tannins. The standard was acetyl salicylic acid for heat-induced method to evaluate the anti-inflammatory and membrane-stabilizing properties. The crude ethanol extract displayed a moderate activity, inhibiting albumin denaturation by 44.7% compared to the positive control. All three extractives also demonstrated significant (p<0.05) in-vitro membrane-stabilizing activity. Additionally, the plant showcased robust antioxidant properties, as evidenced by the IC50 values of the ethanol extract, nhexane extract and chloroform extracts (5.3, 5.4, and 6.2 μg/ml, respectively), one the contrary, the acetyl salicylic acid as standard drug exhibited an IC50 value of 3.8 μg/ml. In summary, the outcomes of this investigation propose that this specific plant species holds promise for the discovery of novel natural bioactive compounds.Bangladesh Pharmaceutical Journal 27(1): 110-115, 2024 (January)
目前的研究工作是调查 Byttneria pilosa Roxb.(科:裸子植物)各种馏分的生物活性并分析其化学成分。对原始馏分提取物的初步检查确定了生物碱、苷类、黄酮类、皂苷、还原糖和单宁酸的存在。热诱导法以乙酰水杨酸为标准,评估其抗炎和膜稳定特性。粗乙醇提取物显示出中等程度的活性,与阳性对照组相比,其抑制白蛋白变性的效果为 44.7%。所有三种提取物在体外膜稳定活性方面也都表现出了显著的效果(p<0.05)。此外,乙醇提取物、正己烷提取物和氯仿提取物的 IC50 值(分别为 5.3、5.4 和 6.2 μg/ml)也证明了该植物具有很强的抗氧化性,相反,作为标准药物的乙酰水杨酸的 IC50 值为 3.8 μg/ml。总之,这项调查的结果表明,这种特殊的植物物种有望发现新型天然生物活性化合物:110-115,2024 年(一月)
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引用次数: 0
In vitro Anti-inflammatory, Antioxidant and Membrane Stabilization Activities of Leaf Extracts of Byttneria pilosa Roxb Byttneria pilosa Roxb 叶提取物的体外抗炎、抗氧化和膜稳定活性
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71161
Bilkis Zohora, A. Faruq, M. Adib, Irin Sultana, M. Chowdhury
This current research work was conducted an investigation into the biological activities of various fractions of Byttneria pilosa Roxb. (Family: Sterculiaceae) and analyze the chemical compositions. Preliminary examination of the raw fractional extractives identified the presence of alkaloids, glycosides, flavonoids, saponins, reducing sugars, and tannins. The standard was acetyl salicylic acid for heat-induced method to evaluate the anti-inflammatory and membrane-stabilizing properties. The crude ethanol extract displayed a moderate activity, inhibiting albumin denaturation by 44.7% compared to the positive control. All three extractives also demonstrated significant (p<0.05) in-vitro membrane-stabilizing activity. Additionally, the plant showcased robust antioxidant properties, as evidenced by the IC50 values of the ethanol extract, nhexane extract and chloroform extracts (5.3, 5.4, and 6.2 μg/ml, respectively), one the contrary, the acetyl salicylic acid as standard drug exhibited an IC50 value of 3.8 μg/ml. In summary, the outcomes of this investigation propose that this specific plant species holds promise for the discovery of novel natural bioactive compounds.Bangladesh Pharmaceutical Journal 27(1): 110-115, 2024 (January)
目前的研究工作是调查 Byttneria pilosa Roxb.(科:裸子植物)各种馏分的生物活性并分析其化学成分。对原始馏分提取物的初步检查确定了生物碱、苷类、黄酮类、皂苷、还原糖和单宁酸的存在。热诱导法以乙酰水杨酸为标准,评估其抗炎和膜稳定特性。粗乙醇提取物显示出中等程度的活性,与阳性对照组相比,其抑制白蛋白变性的效果为 44.7%。所有三种提取物在体外膜稳定活性方面也都表现出了显著的效果(p<0.05)。此外,乙醇提取物、正己烷提取物和氯仿提取物的 IC50 值(分别为 5.3、5.4 和 6.2 μg/ml)也证明了该植物具有很强的抗氧化性,相反,作为标准药物的乙酰水杨酸的 IC50 值为 3.8 μg/ml。总之,这项调查的结果表明,这种特殊的植物物种有望发现新型天然生物活性化合物:110-115,2024 年(一月)
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引用次数: 0
Community-based Descriptive Cross-sectional Study on Prevalence, Clinical Manifestation, Beliefs and Management Approach of Gastroesophageal Reflux Disease (GERD) Among Young Bangladeshi Population 基于社区的描述性横断面研究:孟加拉国年轻人胃食管反流病 (GERD) 的患病率、临床表现、观念和管理方法
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71150
Kazi Milenur Rahman Prattay, Riaz Uddin, Diponkor Kumar Shill, Rajib Das, Md Raihan Sarkar, K. Sikdar
Despite being a common public health problem, there are few population-based research available to learn about the epidemiology and management of gastrointestinal reflux disease (GERD) in Bangladesh. The tenacity of this study was to investigate the prevalence, potential predisposing factors, clinical representation, therapeutic management of GERD among the young Bangladeshi population along with their beliefs regarding the disease. A descriptive cross-sectional study was conducted during 13th June 2022 to 10th December 2022 among 925 individuals (16-35 years of age) from various parts of Bangladesh. A standardized online questionnaire in both English and the local language (Bengali) was utilized to collect all the desired data that were analyzed using either Microsoft Excel 2019 or, IBM SPSS Statistics, v26.0. The prevalence of GERD was 55.7% which was not significantly associated with different sociodemographic parameters. However, family history (Odds ratio (OR) = 2.512), irregular meal (OR = 1.527) and spicy/junk food (OR = 1.495) were significantly associated with GERD prevalence in binary logistic regression analysis. Heart burn (94.0%) and regurgitation (83.3%) were the major symptoms observed and the average number of symptoms was higher in patients with relevant family history (p < 0.0005). Omeprazole (42.5%) was the most used medication to treat GERD followed by other proton pump inhibitors and H2 blockers. Self-medication was practiced by 52.6% of the patients which was associated with duration of treatment (p < 0.0005). The study has found a high prevalence of GERD in Bangladesh. Family history, irregular meal and spicy/junk foods have been identified as potential risk factors and only half the participants had the right belief regarding the effectiveness of lifestyle modification against GERD. Further cohort studies are advised to solidify the findings of this study.Bangladesh Pharmaceutical Journal 27(1): 19-36, 2024 (January)
尽管胃食管反流病(GERD)是一个常见的公共卫生问题,但在孟加拉国,关于胃食管反流病(GERD)的流行病学和治疗方法的人群研究却很少。本研究旨在调查孟加拉国年轻人胃食管反流病的发病率、潜在诱发因素、临床表现、治疗方法以及他们对该疾病的看法。该研究于 2022 年 6 月 13 日至 2022 年 12 月 10 日期间对来自孟加拉国不同地区的 925 人(16-35 岁)进行了描述性横断面研究。该研究使用英语和当地语言(孟加拉语)的标准化在线问卷收集所有所需数据,并使用 Microsoft Excel 2019 或 IBM SPSS Statistics, v26.0 进行分析。胃食管反流病的患病率为 55.7%,与不同的社会人口学参数无明显关联。然而,在二元逻辑回归分析中,家族史(比值比(OR)= 2.512)、不规律进餐(OR = 1.527)和辛辣/垃圾食品(OR = 1.495)与胃食管反流病的患病率有显著相关性。心脏烧灼感(94.0%)和反流(83.3%)是观察到的主要症状,有相关家族史的患者平均症状数量较多(P < 0.0005)。奥美拉唑(42.5%)是治疗胃食管反流病最常用的药物,其次是其他质子泵抑制剂和 H2 受体阻滞剂。52.6%的患者会自行用药,这与治疗时间长短有关(p < 0.0005)。研究发现,胃食管反流病在孟加拉国的发病率很高。家族病史、不规律进餐和辛辣/垃圾食品被认为是潜在的风险因素,只有一半的参与者对改变生活方式预防胃食管反流病的有效性有正确的认识。建议进一步开展队列研究,以巩固本研究的结果:19-36,2024 年(1 月)
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引用次数: 0
Design and Evaluation of Hair Growth - Hair Fall Oil Formulation from Botanicals 植物生发-掉发油配方的设计与评估
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71149
Md Jahid Hossain, Omar Faruk, Dilshad Noor Lira, Diponkor Kumar Shill, A. S. Rouf
Hair loss in adult men albeit common, can cause emotional distress. Many people with hair fall issues try chemical-based treatments that may lead to health complications and allergic reactions. Cosmetics using natural ingredients derived from plants have fewer side effects compared to synthetic alternatives. The study aimed to formulate herbal hair oil using various ingredients like castor oil, sunflower oil, jojoba oil, olive oil, pumpkin oil, etc. and evaluate its effectiveness in promoting hair growth and prevention of hair fall (HG-HF). Besides, the oil was supposed to provide a range of benefits for hair health, including preventing dandruff, improving scalp health, providing antioxidant properties, and thereby protecting against oxidative damage. The DPPH radical scavenging test was done to evaluate the antioxidant activity of the oils. Varying IC50 values were found such as olive oil and sunflower oil showed IC50 values of 3.79 μg/ml and 4.44 μg/ml respectively. Hence, these oils have significant antioxidant activity with a strong ability to scavenge or neutralize free radicals. A study was conducted on sixteen volunteers with hair loss, dandruff, and other hair problems to check the performance of the oil. 56.25% of the participants experienced increased hair growth and 50% reported a decrease in hair fall after using the oil for 3 months, with no remarkable side effects. Data demonstrated effectiveness and overall acceptable perception of the HG-HF oil by the participants.Bangladesh Pharmaceutical Journal 27(1): 9-18, 2024 (January)
成年男性脱发虽然常见,但也会造成情绪困扰。许多有掉发问题的人都尝试过化学疗法,但这些疗法可能会导致健康并发症和过敏反应。与合成替代品相比,使用从植物中提取的天然成分的化妆品副作用更小。这项研究旨在使用蓖麻油、葵花籽油、荷荷巴油、橄榄油、南瓜油等多种成分配制草本发油,并评估其在促进头发生长和防止掉发(HG-HF)方面的功效。此外,这种油应该还能为头发健康提供一系列益处,包括预防头皮屑、改善头皮健康、提供抗氧化特性,从而防止氧化损伤。DPPH 自由基清除试验用于评估精油的抗氧化活性。结果发现,橄榄油和葵花籽油的 IC50 值各不相同,分别为 3.79 μg/ml 和 4.44 μg/ml。因此,这些油具有很强的抗氧化活性,能够清除或中和自由基。研究人员对 16 名脱发、头皮屑和其他头发问题的志愿者进行了研究,以检测精油的性能。56.25% 的参与者在使用该精油 3 个月后,头发生长有所增加,50% 的参与者表示掉发有所减少,而且没有明显的副作用。数据显示了 HG-HF 油的有效性和参与者对它的总体接受度:9-18,2024 年(1 月)
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引用次数: 0
Antidepressant, Antidiarrheal, Thrombolytic and Phytochemical Profiling of Ethanol Extract of Amomum aromaticum Leaves: In vivo and In vitro Approaches 香叶乙醇提取物的抗抑郁、止泻、溶栓和植物化学分析:体内和体外方法
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71152
Enama Nabi Shetu, M. Sayeed, Mohammad Arman, M. Maruf, S. Sayem, M. Islam
The study evaluated several pharmacological effects including antidepressant, antidiarrheal and thrombolytic activities of ethanol extract of Amomum aromaticum leaves (EEAA). Upon the assessment for qualitative phytochemical groups in the extract, several doses of EEAA (1000 - 4000 mg/kg) were studied to find acute oral toxicity in mouse for safe dose selection. Then EEAA was tested whether it demonstrates antidepressant activity in tail suspension test (TST) and forced swim test (FST). Antidiarrheal and clot lysis activities of EEAA were evaluated in castor oil-induced diarrhoea in mouse and In vitro clot lysis method, respectively. Oral administration of EEAA (1000 - 4000 mg/kg) showed no morality after 10 days, and no sign of acute toxicity observed within 24 hrs post-treatment. The qualitative phytochemical screening showed the presence of carbohydrate, alkaloid, flavonoid, tannin, saponin, and polyphenol groups in EEAA. The TST and FST resulted with significant improvement in mobility in mice treated with EEAA (400 mg/kg), where fluoxetine (20 mg/kg) was used as standard in both tests. EEAA treatment also showed a moderate dose-dependent anti-diarrheal effect. The 400 mg/kg oral dosing for 14 days decreased the rate of defecation by 52.8% compared to the control group. This study also demonstrated that EEAA possesses clot lysis activity. Hence, further intense investigations are suggested to identify specific potential active phytochemicals.Bangladesh Pharmaceutical Journal 27(1): 51-58, 2024 (January)
该研究评估了芳香树叶乙醇提取物(EEAA)的多种药理作用,包括抗抑郁、止泻和溶栓活性。在对提取物中的植物化学组进行定性评估后,研究了几种剂量的 EEAA(1000 - 4000 mg/kg),以发现小鼠急性经口毒性,从而选择安全剂量。然后测试了 EEAA 在尾悬试验(TST)和强迫游泳试验(FST)中是否具有抗抑郁活性。在蓖麻油诱导的小鼠腹泻和体外凝块溶解法中,分别评估了 EEAA 的止泻和凝块溶解活性。口服 EEAA(1000 - 4000 毫克/千克)10 天后,小鼠无腹泻症状,且在治疗后 24 小时内未观察到急性毒性迹象。植物化学定性筛选显示,EEAA 中含有碳水化合物、生物碱、黄酮类、单宁、皂苷和多酚类。在以氟西汀(20 毫克/千克)为标准的两项测试中,用 EEAA(400 毫克/千克)治疗小鼠后,TST 和 FST 均显著改善了小鼠的活动能力。EEAA 还显示出中等剂量依赖性的止泻效果。与对照组相比,连续 14 天口服 400 毫克/千克可使排便率降低 52.8%。这项研究还表明,EEAA 具有凝块溶解活性。因此,建议进一步深入研究,以确定特定的潜在活性植物化学物质:51-58,2024 年(一月)
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引用次数: 0
Carvacrol: A Prospective Gold Mine of New Drug Discovery and Development 香芹酚:新药发现和开发的前瞻性金矿
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71154
A. Zaman, Suriya Akter Shampa, Nazim Uddin Ahmed, Md Jasim Uddin, Md Al Amin Miah, Shabiba Parvin Shandhi, Bakul Akter, Safaet Alam
Carvacrol, a widely extracted monoterpenoid phenol from an abundant number of aromatic plant species including thyme and oregano. At present, carvacrol is being utilized in low concentrations as a preservative and food flavoring agent, in addition to serving as a fragrance element in cosmetic formulations. A great deal of study has been done in recent years as an effort to determine the biological effects of carvacrol for possible therapeutic application. Carvacrol has been identified to have a vast range of biological and pharmacological characteristics which include antidiabetic, antimicrobial, antiinflammatory, anti-obesity, antitumor, hepatoprotective, gastroprotective, and neuroprotective effects based on both in vitro and in vivo experiments. The main objective of this review is to assess current understanding of carvacrol's pharmacological impacts as well as its biosynthesis and plant sources in order to potentially inform the future researchers. It can be postulated that upon extensive research, this noteworthy bioactive phytochemical can be a very promising source of next generation drug development.Bangladesh Pharmaceutical Journal 27(1): 116-125, 2024 (January)
香芹酚是从百里香和牛至等大量芳香植物中广泛提取的单萜酚类。目前,除了作为化妆品配方中的香料成分外,香芹酚还被用作低浓度防腐剂和食品调味剂。近年来,人们对香芹酚的生物效应进行了大量研究,以确定其可能的治疗用途。根据体外和体内实验,发现香芹酚具有多种生物和药理特性,包括抗糖尿病、抗菌、抗炎、抗肥胖、抗肿瘤、保肝、保胃和神经保护作用。本综述的主要目的是评估目前对香芹酚的药理作用及其生物合成和植物来源的认识,以便为未来的研究人员提供参考。可以推测,经过广泛研究,这种值得注意的生物活性植物化学物质将成为下一代药物开发的一个非常有前景的来源:孟加拉制药杂志》27(1):116-125,2024 年(1 月
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引用次数: 0
Characterization and In vitro Dissolution Assessment of Pitavastatin-polyvinyl Pyrrolidone and Kollicoat®IR Solid Dispersions Prepared by Solvent Evaporation and Fusion Methodologies 用溶剂蒸发法和熔融法制备的匹伐他汀-聚乙烯吡咯烷酮和 Kollicoat®IR 固体分散体的特性和体外溶出度评估
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71151
Ishtyaque Mikrani, Kazi Milenur Rahman Prattay, Md Raihan Sarkar, K. Sikdar, Mashiur Rahman, Md Abdus Samadd
Pitavastatin (PTV) is a potent lipid lowering drug that acts on hepatocytes by blocking the 3-hydroxy-3- methylglutaryl-CoA reductase enzyme. As a Biopharmaceutical Classification System (BCS) Class II drug, PTV possesses very low water solubility; hence, poor bioavailability leads to poor drug delivery to the target organ. The study aims to develop various PTV solid dispersion (SD) formulations and to investigate the release profile of PTV SD systems. Different PTV physical mixing and SD formulations were prepared using polyvinylpyrrolidone (Kollidon®90F) and Kollicoat®IR hydrophilic polymers by fusion and solvent evaporation approaches. The efficacy of the formulations was evaluated by in vitro PTV release studies. Subsequently, the characterization of SD formulations was performed using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The in vitro release studies confirmed that all the developed formulations showed a comparatively better release percentage (75.31–98.45%) than the pure PTV (61.76%) after 60 min. Additionally, the outcomes showed that raising the concentration of both polymers improved PTV's ability to dissolve. In comparison to physical mixing formulations, SD formulations made using fusion and solvent evaporation processes performed better during dissolution. The TGA, DSC, and FTIR studies confirmed that the tested SD formulations (1:2, 1:3 ratios) were stable at high temperatures with a reduction in crystallinity and no notable interaction between the drug and polymers. The SEM analysis showed that the PTV was evenly spread out in the carriers and that the crystal-like structure of the PTV had changed into an amorphous form.Bangladesh Pharmaceutical Journal 27(1): 37-50, 2024 (January)
匹伐他汀(PTV)是一种强效降脂药,通过阻断 3-hydroxy-3- methylglutaryl-CoA 还原酶作用于肝细胞。作为生物制药分类系统(BCS)的二类药物,PTV 的水溶性非常低,因此生物利用度较低,导致药物难以输送到靶器官。本研究旨在开发各种 PTV 固体分散(SD)制剂,并研究 PTV SD 系统的释放曲线。研究人员使用聚乙烯吡咯烷酮(Kollidon®90F)和 Kollicoat®IR 亲水聚合物,通过熔融和溶剂蒸发方法制备了不同的 PTV 物理混合和 SD 制剂。通过体外 PTV 释放研究评估了制剂的功效。随后,使用热重分析法(TGA)、差示扫描量热法(DSC)、傅立叶变换红外光谱法(FTIR)和扫描电子显微镜法(SEM)对 SD 制剂进行了表征。体外释放研究证实,与纯 PTV(61.76%)相比,所有开发的制剂在 60 分钟后的释放率(75.31%-98.45%)都相对较高。此外,研究结果表明,提高两种聚合物的浓度可提高 PTV 的溶解能力。与物理混合配方相比,使用熔融和溶剂蒸发工艺制作的 SD 配方在溶解过程中表现更好。TGA、DSC 和 FTIR 研究证实,测试的 SD 制剂(1:2、1:3 比例)在高温下稳定,结晶度降低,药物和聚合物之间没有明显的相互作用。扫描电镜分析表明,PTV 在载体中均匀分布,PTV 的晶体结构已变为无定形形式:37-50,2024 年(1 月)
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引用次数: 0
In vitro Assessment of Antioxidant, Membrane Stabilization and Thrombolytic Activities of Ethanolic Extract of Lagenaria siceraria Fruit 西洋接骨木果实乙醇提取物的抗氧化、膜稳定和血栓溶解活性的体外评估
Pub Date : 2024-02-11 DOI: 10.3329/bpj.v27i1.71148
A. Sultana, Abida Sultana, F. Aktar, J. A. Chowdhury, A. A. Chowdhury, Shaila Kabir, Md. Shah Amran
Lagenaria siceraria is a well-known vegetable fruit in Bangladesh. This study aimed to investigate the antioxidant, membrane stabilizing and thrombolytic activities of the ethanolic extract of L. siceraria fruits (EELSF). Total phenolic content and DPPH free radical scavenging activity tests were done to determine antioxidant properties. The anti-inflammatory effects were evaluated using heat- and hypotonic solution induced hemolysis. Human RBC from healthy volunteers were used to assess the thrombolytic activity of the extract. Ethanolic extract of L. siceraria fruits displayed noticeable antioxidant, membrane stabilizing and thrombolytic activities when compared to the standard drugs. Further studies are necessary to evaluate the pharmacological activities of different solvent fractions and plant parts of L. siceraria.Bangladesh Pharmaceutical Journal 27(1): 1-8, 2024 (January)
西洋菜(Lagenaria siceraria)是孟加拉国一种著名的蔬菜水果。本研究旨在探讨鳞茎果实乙醇提取物(EELSF)的抗氧化、膜稳定和溶栓活性。总酚含量和 DPPH 自由基清除活性测试用于确定抗氧化特性。使用热溶血和低渗溶液诱导溶血来评估抗炎效果。用健康志愿者的人体红细胞来评估提取物的溶栓活性。与标准药物相比,西洋参果实乙醇提取物具有明显的抗氧化、稳定膜和溶栓活性。孟加拉药学杂志》27(1),1-8,2024 年 1 月:1-8, 2024 (January)
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引用次数: 0
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Bangladesh Pharmaceutical Journal
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