M. Rashid, J. Sultana, A. Jahan, M. Saifuddin, Md. Selim Reza
The objective of this study is to investigate the prescription pattern of proton pump inhibitors (PPIs) in association with patients’ age, gender and type of hospital visited (government or private), location of the hospital and doctors’ specialty in major divisions of Bangladesh. The secondary objective of this study was to analyze the current market size, share and growth of PPIs in the antiulcer drug market. A crosssectional survey of drug prescriptions was done at hospitals and clinics (private practices) between April 2021 to June 2021 of 7 divisions in Bangladesh. A total of 386 prescriptions, containing 2354 medicines, from 21 districts/areas of 7 divisions in Bangladesh were reviewed to determine the trend of prescribing PPIs. Market data of PPIs were collected from a secondary source (IQVIA). The data collected from the survey were tabulated, analyzed and graphically presented using Microsoft Office Excel 2016. Collected data were entered into the SPSS19.0 statistical software “R” and analyzed. Prescribed antiulcer drugs included Esomeprazole (70.2%), Rabeprazole (7.8%), Omeprazole (4.7%), Dexlansoprazole (4.4%), Pantoprazole (3.1%), and Lansoprazole (0.3%); and 9.3% of collected prescriptions had no anti-ulcerant. There was no association between gender and PPIs prescribed, nor across the type of hospital visited. Only the regression coefficient relating to the patient's age is statistically significant (β=0.01, p<0.05) in overall drug consumption. Along with nonspecific explanations, there were twelve specific reasons for prescribing antiulcer drug generics where the majority of the cases were attributed to NSAID-induced acidity (36%). Bangladesh Pharmaceutical Journal 25(2): 209-217, 2022 (July)
{"title":"A Study on the Prescription Trend of Proton Pump Inhibitors in Major Divisions of Bangladesh","authors":"M. Rashid, J. Sultana, A. Jahan, M. Saifuddin, Md. Selim Reza","doi":"10.3329/bpj.v25i2.60972","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60972","url":null,"abstract":"The objective of this study is to investigate the prescription pattern of proton pump inhibitors (PPIs) in association with patients’ age, gender and type of hospital visited (government or private), location of the hospital and doctors’ specialty in major divisions of Bangladesh. The secondary objective of this study was to analyze the current market size, share and growth of PPIs in the antiulcer drug market. A crosssectional survey of drug prescriptions was done at hospitals and clinics (private practices) between April 2021 to June 2021 of 7 divisions in Bangladesh. A total of 386 prescriptions, containing 2354 medicines, from 21 districts/areas of 7 divisions in Bangladesh were reviewed to determine the trend of prescribing PPIs. Market data of PPIs were collected from a secondary source (IQVIA). The data collected from the survey were tabulated, analyzed and graphically presented using Microsoft Office Excel 2016. Collected data were entered into the SPSS19.0 statistical software “R” and analyzed. Prescribed antiulcer drugs included Esomeprazole (70.2%), Rabeprazole (7.8%), Omeprazole (4.7%), Dexlansoprazole (4.4%), Pantoprazole (3.1%), and Lansoprazole (0.3%); and 9.3% of collected prescriptions had no anti-ulcerant. There was no association between gender and PPIs prescribed, nor across the type of hospital visited. Only the regression coefficient relating to the patient's age is statistically significant (β=0.01, p<0.05) in overall drug consumption. Along with nonspecific explanations, there were twelve specific reasons for prescribing antiulcer drug generics where the majority of the cases were attributed to NSAID-induced acidity (36%).\u0000Bangladesh Pharmaceutical Journal 25(2): 209-217, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83040933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sumayea Kabir Saba, F. Khan, Samantha Lamia, Md. Iqbal Shahid, Tahsin Anika, S. Akhter, Khadizatul Fariha Chowdhury, Umma Mysha Tannum Arpita, Shanta Islam, Khandaker Amirul Momenin, Shah Alam, Kanij Fatima Tisha, Md. Jamal Hossain, Md. Harun Or Rashid, M. Sarker
COVID-19 is a pandemic malady caused by SARS-CoV-2, a novel coronavirus. It is a global threat that has affected 223 countries and territories all over the world. According to the WHO report as of April 06, 2022 coronavirus has affected 492,189,439 people globally with 6,159,474 confirmed deaths. The pandemic of COVID-19 has badly affected Bangladesh likewise many other countries of the world. According to Worldometer report on 06 April 2022 the number of confirmed cases of COVID-19 were 1,951,903 with 29,123 deaths, and 1,886,036 COVID-19 recoveries in Bangladesh. After originating from China, this notorious virus has been spread to almost all the countries of the world. Its spike protein aids in binding with the ACE2 receptors of the cell membrane resulting in cell entry, replication, and induction of inflammatory and pro-inflammatory responses leading to the pathogenic condition. The novel COVID-19 virus has structural and genetic similarity with its predecessors specially SARS-CoV and MERS-CoV. This review presents the existing literature on COVID-19 and discusses different aspects of COVID-19 including virology, etiology, epidemiology, pathogenesis, diagnosis, transmission and susceptibility and preventive measures of COVID-19. Bangladesh Pharmaceutical Journal 25(2): 143-163, 2022 (July)
{"title":"Updates on COVID-19: Virology, Etiology, Epidemiology, Pathogenesis, Diagnosis, Transmission and Prevention","authors":"Sumayea Kabir Saba, F. Khan, Samantha Lamia, Md. Iqbal Shahid, Tahsin Anika, S. Akhter, Khadizatul Fariha Chowdhury, Umma Mysha Tannum Arpita, Shanta Islam, Khandaker Amirul Momenin, Shah Alam, Kanij Fatima Tisha, Md. Jamal Hossain, Md. Harun Or Rashid, M. Sarker","doi":"10.3329/bpj.v25i2.60966","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60966","url":null,"abstract":"COVID-19 is a pandemic malady caused by SARS-CoV-2, a novel coronavirus. It is a global threat that has affected 223 countries and territories all over the world. According to the WHO report as of April 06, 2022 coronavirus has affected 492,189,439 people globally with 6,159,474 confirmed deaths. The pandemic of COVID-19 has badly affected Bangladesh likewise many other countries of the world. According to Worldometer report on 06 April 2022 the number of confirmed cases of COVID-19 were 1,951,903 with 29,123 deaths, and 1,886,036 COVID-19 recoveries in Bangladesh. After originating from China, this notorious virus has been spread to almost all the countries of the world. Its spike protein aids in binding with the ACE2 receptors of the cell membrane resulting in cell entry, replication, and induction of inflammatory and pro-inflammatory responses leading to the pathogenic condition. The novel COVID-19 virus has structural and genetic similarity with its predecessors specially SARS-CoV and MERS-CoV. This review presents the existing literature on COVID-19 and discusses different aspects of COVID-19 including virology, etiology, epidemiology, pathogenesis, diagnosis, transmission and susceptibility and preventive measures of COVID-19.\u0000Bangladesh Pharmaceutical Journal 25(2): 143-163, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84619970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aphananthe Aspera (Thunb.) Planch. is a towering woody deciduous tree and belongs to riparian forest territory. It is highly allocated to the Northern region of Eastern Asia especially Korea, China, Northern Vietnam, and Japan to be the richest countries with this species. The plants were assayed based on various types of methods including extraction. Based on folkloric usage it is important to treat acne, inflammation and cancer. Google Scholar, Web of Science, PubMed, Science Direct, and MEDLINE etc. are the electronic versions from which many bibliographic records were thoroughly explored to identify, collect, and analyze available information relevant to A. aspera. The extracted data were scrutinized in order to have a better understanding of the existing research on this species and to look into the plant's future potential in pharmaceutical research. This study aims to offer current knowledge on botany, distribution, ethnomedicinal applications, pharmacological actions, clinical study and reported phytochemicals of A. aspera. Finally, this plant is still recommended for extensive research to explore prospective novel sources of novel therapeutic agents as there are very little data available on this plant to the best of our knowledge. Extensive research on this plant can open a new horizon to discover novel therapeutics. Bangladesh Pharmaceutical Journal 25(2): 218-228, 2022 (July)
阿凡纳斯(拇指)木板。是一种高耸的木本落叶乔木，属于河岸林范畴。它高度分布于东亚北部地区，特别是韩国、中国、越南北部和日本，是该物种最丰富的国家。采用包括提取在内的各种方法对植物进行了测定。根据民间习惯，它对治疗痤疮、炎症和癌症很重要。谷歌Scholar、Web of Science、PubMed、Science Direct和MEDLINE等电子版本对许多书目记录进行了深入的研究，以识别、收集和分析与沙曲霉有关的可用信息。对提取的数据进行了仔细审查，以便更好地了解对该物种的现有研究，并研究该植物在药物研究中的未来潜力。本文主要介绍了沙刺草的植物学、分布、民族医药应用、药理作用、临床研究和已报道的植物化学成分等方面的研究进展。最后，这种植物仍然被推荐进行广泛的研究，以探索新的治疗药物的潜在新来源，因为据我们所知，这种植物的可用数据很少。对这种植物的广泛研究可以为发现新的治疗方法开辟新的视野。孟加拉国药学杂志25(2):218- 228,2022(7月)
{"title":"Aphananthe aspera (Thunb.) Planch.: An Unexploited Eastern Asian Species from the Center of Biodiversity","authors":"Maliha Momtaj, Safaet Alam, A. Sultana, M. Rashid","doi":"10.3329/bpj.v25i2.60973","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60973","url":null,"abstract":"Aphananthe Aspera (Thunb.) Planch. is a towering woody deciduous tree and belongs to riparian forest territory. It is highly allocated to the Northern region of Eastern Asia especially Korea, China, Northern Vietnam, and Japan to be the richest countries with this species. The plants were assayed based on various types of methods including extraction. Based on folkloric usage it is important to treat acne, inflammation and cancer. Google Scholar, Web of Science, PubMed, Science Direct, and MEDLINE etc. are the electronic versions from which many bibliographic records were thoroughly explored to identify, collect, and analyze available information relevant to A. aspera. The extracted data were scrutinized in order to have a better understanding of the existing research on this species and to look into the plant's future potential in pharmaceutical research. This study aims to offer current knowledge on botany, distribution, ethnomedicinal applications, pharmacological actions, clinical study and reported phytochemicals of A. aspera. Finally, this plant is still recommended for extensive research to explore prospective novel sources of novel therapeutic agents as there are very little data available on this plant to the best of our knowledge. Extensive research on this plant can open a new horizon to discover novel therapeutics.\u0000Bangladesh Pharmaceutical Journal 25(2): 218-228, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72942841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The rhizome of Canna indica L. (family: Cannaceae) was extracted in methanol and two doses- 200 and 400 mg/kg body weight of the extract were employed to reveal central and peripheral analgesic, hypoglycemic and antidiarrheal properties in vivo. According to tail immersion technique, both doses significantly rose the time of latent response for 90 minutes compared to control mice group in assessing central analgesia. Acetic acid-induced writhing process demonstrated 37.29% and 64.41% inhibition of mice movement at both doses, respectively which indicated promising and statistically significant peripheral analgesic effect. On the other hand, hypoglycemic and antidiarrheal activities maintained dose and time dependent manner. Moreover, the extract of rhizome displayed statistically significant antidiarrheal activity at 400 mg/kg b.w. dose. Bangladesh Pharmaceutical Journal 25(2): 137-142, 2022 (July)
{"title":"Analgesic, Hypoglycemic and Antidiarrheal Activities Screening of Canna indica L.","authors":"N. Sultana, Mahfuza Afroz Soma, Md. Abdur Rashid","doi":"10.3329/bpj.v25i2.60965","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60965","url":null,"abstract":"The rhizome of Canna indica L. (family: Cannaceae) was extracted in methanol and two doses- 200 and 400 mg/kg body weight of the extract were employed to reveal central and peripheral analgesic, hypoglycemic and antidiarrheal properties in vivo. According to tail immersion technique, both doses significantly rose the time of latent response for 90 minutes compared to control mice group in assessing central analgesia. Acetic acid-induced writhing process demonstrated 37.29% and 64.41% inhibition of mice movement at both doses, respectively which indicated promising and statistically significant peripheral analgesic effect. On the other hand, hypoglycemic and antidiarrheal activities maintained dose and time dependent manner. Moreover, the extract of rhizome displayed statistically significant antidiarrheal activity at 400 mg/kg b.w. dose.\u0000Bangladesh Pharmaceutical Journal 25(2): 137-142, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79631623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is an utmost urgency of having new and advanced diagnostics as well as therapeutic alternatives along with the conventional methods to treat coronavirus disease 2019 (COVID-19). For this purpose, different strategies must be explored for the advancement of testing capacity, developing effective treatments, and developing safe vaccines that provide long-term immunity. Nanotechnology has been found effective against COVID-19 in terms of diagnosis, prevention, and treatment. The diameter of SARS-CoV-2 (60–140 nm) is similar to nanoparticles. This is why, synthetic nanoparticles can precisely resemble SARS-CoV-2, and efficiently interact with the viral proteins and counter this virus. Nanotechnology offers benefits by developing efficient and cost-effective diagnosis methods and facilitating the improvement of drug properties through nano-carriers, namely liposomes, micelles, metallic nanoparticles, etc. The bibliometric analysis evaluates scholarly contributions using mathematical and statistical methodologies. In this study, the bibliometric analysis investigated the publication trends of nanoparticles and their application in COVID-19 diagnosis and treatment. We have systematically searched the different search engines and publishers (Scopus, PubMed, and Google scholar) from 2020 to 2021, and various visual maps were generated to show, the most- relevant authors, sources, countries, topics, and keywords by using a software called VOSviewer. The findings indicate the advancement of nanotechnology in the diagnosis and therapy of COVID-19. At last, the bibliometric analysis of nanoparticles for COVID-19 diagnosis and treatment provides a clear view of the future research directions and identifies the potential challenges and opportunities. This may pave the way for new researchers to find the proper subfields in nanoparticle-related research areas for combating the COVID-19. Bangladesh Pharmaceutical Journal 25(2): 199-208, 2022 (July)
{"title":"Nanotechnology in COVID-19 Diagnosis and Treatment: A Bibliometric Analysis","authors":"Ripa Kundu, Faria Nasrin, T. Saha, Md. Selim Reza","doi":"10.3329/bpj.v25i2.60971","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60971","url":null,"abstract":"There is an utmost urgency of having new and advanced diagnostics as well as therapeutic alternatives along with the conventional methods to treat coronavirus disease 2019 (COVID-19). For this purpose, different strategies must be explored for the advancement of testing capacity, developing effective treatments, and developing safe vaccines that provide long-term immunity. Nanotechnology has been found effective against COVID-19 in terms of diagnosis, prevention, and treatment. The diameter of SARS-CoV-2 (60–140 nm) is similar to nanoparticles. This is why, synthetic nanoparticles can precisely resemble SARS-CoV-2, and efficiently interact with the viral proteins and counter this virus. Nanotechnology offers benefits by developing efficient and cost-effective diagnosis methods and facilitating the improvement of drug properties through nano-carriers, namely liposomes, micelles, metallic nanoparticles, etc. The bibliometric analysis evaluates scholarly contributions using mathematical and statistical methodologies. In this study, the bibliometric analysis investigated the publication trends of nanoparticles and their application in COVID-19 diagnosis and treatment. We have systematically searched the different search engines and publishers (Scopus, PubMed, and Google scholar) from 2020 to 2021, and various visual maps were generated to show, the most- relevant authors, sources, countries, topics, and keywords by using a software called VOSviewer. The findings indicate the advancement of nanotechnology in the diagnosis and therapy of COVID-19. At last, the bibliometric analysis of nanoparticles for COVID-19 diagnosis and treatment provides a clear view of the future research directions and identifies the potential challenges and opportunities. This may pave the way for new researchers to find the proper subfields in nanoparticle-related research areas for combating the COVID-19.\u0000Bangladesh Pharmaceutical Journal 25(2): 199-208, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79015007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rashid, Juthika Das, Anika Akter, J. Uddin, Nazni Parvin, F. R. Laboni, M. Sarker, Nurul Karim
Eclipta prostata (E. prostata) L, is a herbal medicinal plant, which is reported to contain phenolics and flavonoids, but very little is known about its bioactive potentials. In this report, we reexamined the phenols and flavonoid content and evaluated different bioactivities of organic soluble fractions from the shoots of E. prostata for the first time. Among the extractives, chloroform soluble fraction (CSF) possessed the highest content of phenols (156.03 ± 0.52 mg gallic acid equivalent /g of dry extract) and flavonoids (67.47 ± 0.56 mg quercetin equivalent /g of dry extract) and exhibited the most potent antioxidant properties in terms of total antioxidant capacity (198.71 ± 0.89 mg ascorbic acid equivalent/g of dry extract) and DPPH free radical scavenging ability (IC50; 17.68 ± 0.32 μg/ml). Similarly, CSF showed the highest cytotoxicity with LC50 values of 16.03±0.23 μg/ml, and thrombolytic activity with 36.06 ± 0.39% clot lysis. A significant correlation was observed between flavonoid content and total antioxidant capacity (r2 = 0.894, p < 0.05), while high correlation was seen between polyphenols and flavonoid content with free radical scavenging, total antioxidant capacity and cytotoxicity (r2 = 0.612 - 0.928). These findings suggest that E. prostata is a precious source of polyphenols having potential bioactivities, which could be utilized for the management of lifestyle diseases. Bangladesh Pharmaceutical Journal 25(2): 164-174, 2022 (July)
黄竹(Eclipta prostata, E. prostata) L)是一种中草药植物，据报道含有酚类物质和类黄酮，但对其生物活性潜力知之甚少。本文首次对前列腺芽有机可溶性组分的酚类和类黄酮含量进行了重新测定，并对其生物活性进行了评价。其中，氯仿可溶性部位(CSF)的酚类含量最高(156.03±0.52 mg没食子酸当量/g)，黄酮类含量最高(67.47±0.56 mg槲皮素当量/g)，总抗氧化能力最高(198.71±0.89 mg抗坏血酸当量/g)，清除DPPH自由基的能力最高(IC50;17.68±0.32 μg/ml)。同样，CSF显示出最高的细胞毒性，LC50值为16.03±0.23 μg/ml，溶栓活性为36.06±0.39%。黄酮类含量与总抗氧化能力呈极显著相关(r2 = 0.894, p < 0.05)，多酚类和黄酮类含量与自由基清除能力、总抗氧化能力和细胞毒性呈极显著相关(r2 = 0.612 ~ 0.928)。这些发现提示前列腺芽胞杆菌是多酚的宝贵来源，具有潜在的生物活性，可用于生活方式疾病的治疗。孟加拉国医药杂志25(2):164-174,2022(7月)
{"title":"Possible Role of Phenolics and Flavonoids in Antioxidant, Cytotoxic and Thrombolytic Activities of Eclipta prostata L.","authors":"M. Rashid, Juthika Das, Anika Akter, J. Uddin, Nazni Parvin, F. R. Laboni, M. Sarker, Nurul Karim","doi":"10.3329/bpj.v25i2.60967","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60967","url":null,"abstract":"Eclipta prostata (E. prostata) L, is a herbal medicinal plant, which is reported to contain phenolics and flavonoids, but very little is known about its bioactive potentials. In this report, we reexamined the phenols and flavonoid content and evaluated different bioactivities of organic soluble fractions from the shoots of E. prostata for the first time. Among the extractives, chloroform soluble fraction (CSF) possessed the highest content of phenols (156.03 ± 0.52 mg gallic acid equivalent /g of dry extract) and flavonoids (67.47 ± 0.56 mg quercetin equivalent /g of dry extract) and exhibited the most potent antioxidant properties in terms of total antioxidant capacity (198.71 ± 0.89 mg ascorbic acid equivalent/g of dry extract) and DPPH free radical scavenging ability (IC50; 17.68 ± 0.32 μg/ml). Similarly, CSF showed the highest cytotoxicity with LC50 values of 16.03±0.23 μg/ml, and thrombolytic activity with 36.06 ± 0.39% clot lysis. A significant correlation was observed between flavonoid content and total antioxidant capacity (r2 = 0.894, p < 0.05), while high correlation was seen between polyphenols and flavonoid content with free radical scavenging, total antioxidant capacity and cytotoxicity (r2 = 0.612 - 0.928). These findings suggest that E. prostata is a precious source of polyphenols having potential bioactivities, which could be utilized for the management of lifestyle diseases.\u0000Bangladesh Pharmaceutical Journal 25(2): 164-174, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89814459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) working as a non-selective cyclooxygenase (COX) inhibitor to treat inflammation, pain, fever, and various disease conditions. The current study was conducted to determine and compare several in vitro quality parameters, often commercially available 500 mg naproxen brands available in Bangladesh. According to the existing protocols, different physical parameters such as uniformity of weight, hardness, friability, disintegration time and dissolution were determined. A validated UV-visible spectrophotometric approach was used to assess the content uniformity of drug material in the collected brands. All the brands taken for this study complied with the official specifications of physical parameters. These brands contained active ingredients ranging from 91.37% up to 101.18%. On the other hand, two brands (C4 and C8) of naproxen tablets failed to meet the specification of United States Pharmacopoeia (USP), 90-110% of the labeled claim for the 500 mg naproxen tablet. These sub-standard brands possessed only 88.16% and 86.67% naproxen sodium. In conclusion, the current study indicated that eight out of the ten brands complied with quality parameters and can be used correspondingly. Bangladesh Pharmaceutical Journal 25(2): 175-179, 2022 (July)
{"title":"Quantitative and Qualitative Estimation of Marketed Naproxen Tablets Available in Bangladesh","authors":"Tanoy Saha, Md. Hassan Kawsar, Md. kamrul Islam, Safaet Alam, Mirazul Islam, Nafla Hakim, Md. Jamal Hossain","doi":"10.3329/bpj.v25i2.60968","DOIUrl":"https://doi.org/10.3329/bpj.v25i2.60968","url":null,"abstract":"Naproxen is a non-steroidal anti-inflammatory drug (NSAID) working as a non-selective cyclooxygenase (COX) inhibitor to treat inflammation, pain, fever, and various disease conditions. The current study was conducted to determine and compare several in vitro quality parameters, often commercially available 500 mg naproxen brands available in Bangladesh. According to the existing protocols, different physical parameters such as uniformity of weight, hardness, friability, disintegration time and dissolution were determined. A validated UV-visible spectrophotometric approach was used to assess the content uniformity of drug material in the collected brands. All the brands taken for this study complied with the official specifications of physical parameters. These brands contained active ingredients ranging from 91.37% up to 101.18%. On the other hand, two brands (C4 and C8) of naproxen tablets failed to meet the specification of United States Pharmacopoeia (USP), 90-110% of the labeled claim for the 500 mg naproxen tablet. These sub-standard brands possessed only 88.16% and 86.67% naproxen sodium. In conclusion, the current study indicated that eight out of the ten brands complied with quality parameters and can be used correspondingly.\u0000Bangladesh Pharmaceutical Journal 25(2): 175-179, 2022 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90907394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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