Drug-drug interactions (DDIs) represent an important clinical problem. During inpatient admissions, infants, children, and adolescents are typically exposed to different medications, increasing their risk of potential drug-drug interactions (pDDIs). While drug interactions are reported to be common, there are only few publications of the prevalence of such interactions among pediatric patients in Bangladesh. The present study tries to estimates the prevalence and characteristics of pDDI exposure of pediatric patients treated in children’s hospitals. This observational retrospective study was carried out on 155 patients admitted to a children’s hospital located at Dhaka during January 2019 to August 2019. The medications of the patients were analyzed for pDDIs by using Medscape drug interaction checker. The prescriptions were analyzed for demographic characteristics, medical and detailed drug history. Drug-drug interactions (DDIs) were evaluated for total numbers, types and severity of DDIs. Total 155 prescriptions with mean age 2.12±2.08 years were analyzed and a total of 25 pDDIs were recorded. The prevalence of pDDI was 17%, of which 12 (48%) were pharmacodynamic interactions, 10 (40%) were pharmacokinetic interactions and 3 (12%) of unknown mechanism. According to the severity of interaction, 4 (18%) cases were categorized as serious, 15 (55%) cases as moderate and 6 (27%) cases as minor. The occurrence of DDIs were significantly associated (r=0.912, p<0.05) with the number of drugs prescribed. The present study has identified pDDIs and also documented interactions in pediatrics patients. It has highlighted the need for screening prescriptions of pediatric patients for pDDIs and proactive monitoring of patients who have identified risk factors in order to promote detection and prevention of possible adverse drug interactions. Bangladesh Pharmaceutical Journal 24(2): 91-98, 2021
{"title":"Assessment of Interactions of Drugs Prescribed for Pediatric Patients in Bangladesh","authors":"S. Ahmed, S. Yesmine, Mizanur Rahman, M. Shahriar","doi":"10.3329/BPJ.V24I2.54706","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54706","url":null,"abstract":"Drug-drug interactions (DDIs) represent an important clinical problem. During inpatient admissions, infants, children, and adolescents are typically exposed to different medications, increasing their risk of potential drug-drug interactions (pDDIs). While drug interactions are reported to be common, there are only few publications of the prevalence of such interactions among pediatric patients in Bangladesh. The present study tries to estimates the prevalence and characteristics of pDDI exposure of pediatric patients treated in children’s hospitals. This observational retrospective study was carried out on 155 patients admitted to a children’s hospital located at Dhaka during January 2019 to August 2019. The medications of the patients were analyzed for pDDIs by using Medscape drug interaction checker. The prescriptions were analyzed for demographic characteristics, medical and detailed drug history. Drug-drug interactions (DDIs) were evaluated for total numbers, types and severity of DDIs. Total 155 prescriptions with mean age 2.12±2.08 years were analyzed and a total of 25 pDDIs were recorded. The prevalence of pDDI was 17%, of which 12 (48%) were pharmacodynamic interactions, 10 (40%) were pharmacokinetic interactions and 3 (12%) of unknown mechanism. According to the severity of interaction, 4 (18%) cases were categorized as serious, 15 (55%) cases as moderate and 6 (27%) cases as minor. The occurrence of DDIs were significantly associated (r=0.912, p<0.05) with the number of drugs prescribed. The present study has identified pDDIs and also documented interactions in pediatrics patients. It has highlighted the need for screening prescriptions of pediatric patients for pDDIs and proactive monitoring of patients who have identified risk factors in order to promote detection and prevention of possible adverse drug interactions. \u0000Bangladesh Pharmaceutical Journal 24(2): 91-98, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85127040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ampelocissus barbata (Wall.) Planch. is a native medicinal herb in Bangladesh. The present study was aimed at exploring the phytochemical compositions and analgesic potential of the plant in vivo. The methanol extract of A. barbata along with its different fractions were subjected to phytochemical evaluation through established chemical tests for ascertaining the available pool of secondary metabolites within the plant. Eventually, the presence of at least eleven classes of phytoconstituents viz. alkaloids, flavonoids, phenolics, glycosides, saponins, starch, phytosterols, coumarins, tanins, resins and quinones were demonstrated. Among the four partitonates, ethyl acetate soluble fraction of A. barbata illustrated the maximum types of secondary metabolites qualitatively. The ability of the crude methanol extract (MEAB) and its ethyl acetate soluble fraction (EAAB) to suppress nociception both centrally and peripherally were investigated in Swiss albino mice by tail immersion method and acetic acid-induced writhing method, respectively. At the 90th minute of the tail immersion study, both MEAB and EAAB administered at the doses of 250 and 500 mg/kg body weight (MEAB1, MEAB2, EAAB1, EAAB2) exhibited 240.41%, 285.34%, 302.83% and 339.60% elongation of pain response, respectively, in comparison to the standard, pentazocine which effectuated 421.36% elongation at the same mark. Moreover, the test samples at the same doses as before exhibited reduction of pain sensation by 66.81%, 74.08%, 76.81%, and 83.52%, respectively, in the acetic acid-induced writhing response in mice. Both the central and peripheral analgesic potentials of EAAB were discernibly higher than those of MEAB at both doses. The findings of the study represents the pharmacological potential of this species in appropriate animal model for the first time and provides valid foundation to warrant future scientific endeavors into the plant. Bangladesh Pharmaceutical Journal 24(2): 117-124, 2021
{"title":"Phytochemical Screening and In vivo Analgesic Activity of Ampelocissus barbata (Wall.) Planch.","authors":"Labony Khandokar, Sanjida Rahman Mim, Rasel Rana","doi":"10.3329/BPJ.V24I2.54710","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54710","url":null,"abstract":"Ampelocissus barbata (Wall.) Planch. is a native medicinal herb in Bangladesh. The present study was aimed at exploring the phytochemical compositions and analgesic potential of the plant in vivo. The methanol extract of A. barbata along with its different fractions were subjected to phytochemical evaluation through established chemical tests for ascertaining the available pool of secondary metabolites within the plant. Eventually, the presence of at least eleven classes of phytoconstituents viz. alkaloids, flavonoids, phenolics, glycosides, saponins, starch, phytosterols, coumarins, tanins, resins and quinones were demonstrated. Among the four partitonates, ethyl acetate soluble fraction of A. barbata illustrated the maximum types of secondary metabolites qualitatively. The ability of the crude methanol extract (MEAB) and its ethyl acetate soluble fraction (EAAB) to suppress nociception both centrally and peripherally were investigated in Swiss albino mice by tail immersion method and acetic acid-induced writhing method, respectively. At the 90th minute of the tail immersion study, both MEAB and EAAB administered at the doses of 250 and 500 mg/kg body weight (MEAB1, MEAB2, EAAB1, EAAB2) exhibited 240.41%, 285.34%, 302.83% and 339.60% elongation of pain response, respectively, in comparison to the standard, pentazocine which effectuated 421.36% elongation at the same mark. Moreover, the test samples at the same doses as before exhibited reduction of pain sensation by 66.81%, 74.08%, 76.81%, and 83.52%, respectively, in the acetic acid-induced writhing response in mice. Both the central and peripheral analgesic potentials of EAAB were discernibly higher than those of MEAB at both doses. The findings of the study represents the pharmacological potential of this species in appropriate animal model for the first time and provides valid foundation to warrant future scientific endeavors into the plant. \u0000Bangladesh Pharmaceutical Journal 24(2): 117-124, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73842530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Safaet Alam, N. Emon, Sadman Hasib, M. Rashid, Mahfuza Afroz Soma, Tanoy Saha, M. R. Haque
Dillenia pentagyna Roxb., a deciduous and medium sized tree, is an ethnobotanically important species of several Asian countries including Bangladesh, Srilanka, and India. Various parts of this endangered tree including leaf, bark, root etc. are used in folkloric medicine systems for a very long time. It is locally used in the treatment of pain, wound healing, diabetes, diarrhea and other disease states. Molecular docking is an important technique to validate the exerted pharmacological actions of a plant or specific phytoconstituents by assessing the binding affinity and interaction pattern between small molecules and particular target receptors. Thus, to justify the notable ethnobotanical importances of D. pentagyna, an in silico study was designed employing selected phytochemicals i.e. isorhamnetin, lupeol, quercetin, kaempferol, and betulin isolated from this plant based on previous literature searches. The molecular docking revealed strong binding affinities (-4.8 to -12.9 kcal/mol) with the respective target proteins: 2OYE, 6COX, 4YK5, 5ZHP, and 1A5H. Besides, in accordance with the Lipinski’s rules, all five selected compounds of D. pentagyna showed promising orally active drug-like characteristics. To recapitulate, the present study has been found parallel with the existing ethnobotanical significance of D. pentagyna as the source of pain, fever, thrombosis, and diarrhea management agent. Bangladesh Pharmaceutical Journal 24(2): 125-132, 2021
{"title":"Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study","authors":"Safaet Alam, N. Emon, Sadman Hasib, M. Rashid, Mahfuza Afroz Soma, Tanoy Saha, M. R. Haque","doi":"10.3329/BPJ.V24I2.54711","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54711","url":null,"abstract":"Dillenia pentagyna Roxb., a deciduous and medium sized tree, is an ethnobotanically important species of several Asian countries including Bangladesh, Srilanka, and India. Various parts of this endangered tree including leaf, bark, root etc. are used in folkloric medicine systems for a very long time. It is locally used in the treatment of pain, wound healing, diabetes, diarrhea and other disease states. Molecular docking is an important technique to validate the exerted pharmacological actions of a plant or specific phytoconstituents by assessing the binding affinity and interaction pattern between small molecules and particular target receptors. Thus, to justify the notable ethnobotanical importances of D. pentagyna, an in silico study was designed employing selected phytochemicals i.e. isorhamnetin, lupeol, quercetin, kaempferol, and betulin isolated from this plant based on previous literature searches. The molecular docking revealed strong binding affinities (-4.8 to -12.9 kcal/mol) with the respective target proteins: 2OYE, 6COX, 4YK5, 5ZHP, and 1A5H. Besides, in accordance with the Lipinski’s rules, all five selected compounds of D. pentagyna showed promising orally active drug-like characteristics. To recapitulate, the present study has been found parallel with the existing ethnobotanical significance of D. pentagyna as the source of pain, fever, thrombosis, and diarrhea management agent. \u0000Bangladesh Pharmaceutical Journal 24(2): 125-132, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"41 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89510720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Alam, Shahidul Islam, K. Sikdar, Asm Monjur Al Hossain
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed by the physicians for the management of pain due to their anti-inflammatory and analgesic properties. Long term use of NSAIDs causes gastrointestinal (GI) toxicity and the common GI disorders are indigestion, ulcers or bleeding. Therefore, the production of local oral tablets containing NSAIDs and gastro-protectant is inevitable. In this experiment, combination of ibuprofen 600 mg and famotidine 20 mg tablets were prepared by direct compression technique, which is unique in Bangladesh. To pursue the study Design of Experiments (DoE) approach was implemented to create fifteen trial formulations where Polyvinylpyrrolidone (PVPK30) 1%-3%, Microcrystalline Cellulose (Avicel PH-102) 1%-7% and Starch-1500 1%-13% were considered as independent variables and the responses were depicted in friability and disintegration time which were found 0.21–0.45% and 1.8–20.5 minutes respectively. Out of fifteen formulation trials (F-1 to F-15), seven formulations (F-3, F-6, F-8, F-9, F-10, F-13 and F-14) had met the acceptable criteria and one formulation (F-9) with independent variables PVP-K30 2.00%, Avicel PH-102 4.75% and Starch-1500 6.5% was selected because of its better disintegration, dissolution and friability profile. Data obtained from in-vitro dissolution tests were fitted to different kinetic models such as zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas models. Also, a compatibility study was conducted using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA) and X-Ray Diffraction (XRD). Furthermore, Scanning Electron Microscopy (SEM) was performed to analyze surface morphology. Finally, the selected formulation was compared to FDA regulated QC parameters and proved its superiority over conventional market products. Bangladesh Pharmaceutical Journal 24(2): 133-148, 2021
{"title":"Formulation and Evaluation of Fixed-Dose Combination Immediate Release Tablets of Ibuprofen and Famotidine through Quality by Design Approach","authors":"M. Alam, Shahidul Islam, K. Sikdar, Asm Monjur Al Hossain","doi":"10.3329/BPJ.V24I2.54712","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54712","url":null,"abstract":"Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed by the physicians for the management of pain due to their anti-inflammatory and analgesic properties. Long term use of NSAIDs causes gastrointestinal (GI) toxicity and the common GI disorders are indigestion, ulcers or bleeding. Therefore, the production of local oral tablets containing NSAIDs and gastro-protectant is inevitable. In this experiment, combination of ibuprofen 600 mg and famotidine 20 mg tablets were prepared by direct compression technique, which is unique in Bangladesh. To pursue the study Design of Experiments (DoE) approach was implemented to create fifteen trial formulations where Polyvinylpyrrolidone (PVPK30) 1%-3%, Microcrystalline Cellulose (Avicel PH-102) 1%-7% and Starch-1500 1%-13% were considered as independent variables and the responses were depicted in friability and disintegration time which were found 0.21–0.45% and 1.8–20.5 minutes respectively. Out of fifteen formulation trials (F-1 to F-15), seven formulations (F-3, F-6, F-8, F-9, F-10, F-13 and F-14) had met the acceptable criteria and one formulation (F-9) with independent variables PVP-K30 2.00%, Avicel PH-102 4.75% and Starch-1500 6.5% was selected because of its better disintegration, dissolution and friability profile. Data obtained from in-vitro dissolution tests were fitted to different kinetic models such as zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas models. Also, a compatibility study was conducted using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA) and X-Ray Diffraction (XRD). Furthermore, Scanning Electron Microscopy (SEM) was performed to analyze surface morphology. Finally, the selected formulation was compared to FDA regulated QC parameters and proved its superiority over conventional market products. \u0000Bangladesh Pharmaceutical Journal 24(2): 133-148, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"450 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76548398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mst Jasmin Akter, Sekendar Ali, Iffat Hasnin, N. A. Khatune, A. Rahman
The study aims to assess the cytotoxic activity of the methanolic extract (CME) and various fractions from the bark of Dillenia indica L (Family: Dilleniaceae) using brine shrimp lethality bioassay and sedative activities using hole cross, open field, and elevated-plus maze (EPM) test in Swiss albino mice. In brine shrimp assay, the LC50 for CME, pet-ether (PETF), chloroform (CHF) and aqueous (AQF) fraction were found to be 110, 24.55, 85 and 14.45 μg/ml, respectively, indicating significant cytotoxicity of PETF and AQF when compared to the standard vincristine sulfate (7.5 μg/ml). In open field test, the number of movements per min (after 120 min) was 40.90, 12.43, 5.45, 3.66, and 29.74 for control, standard diazepam, CME, CHF and AQF, respectively, indicating strong activity of the chloroform soluble fraction compared to the other test samples of D. indica. Similar data was observed in hole cross test where the number of movements per minute after 120 min were 3.60, 5.56, 4.77, and 7.99 for the standard, CME, CHF and AQF, respectively. In EPM test, the CME showed a significant decreased percentage of entries of mice into the open arms of EPM as well as the percentage of time spent in the open arms. The result indicates that the CHF significantly suppressed the locomotor activity than that of methanol and aqueous fractions. These findings will be helpful for bioassay-guided isolation of active principles responsible for cytotoxicity and sedative activities. Bangladesh Pharmaceutical Journal 24(2): 105-110, 2021
本研究旨在通过盐水对虾致死生物测定和孔交叉、空地和升高+迷宫(EPM)实验对瑞士白化病小鼠的镇静作用进行评价。在盐水对虾实验中，CME、pet-醚(PETF)、氯仿(CHF)和水溶液(AQF)的LC50分别为110、24.55、85和14.45 μg/ml，与标准硫酸长春新碱(7.5 μg/ml)相比，PETF和AQF具有显著的细胞毒性。在野外试验中，对照、标准安定、CME、CHF和AQF的运动次数分别为40.90次、12.43次、5.45次、3.66次和29.74次/ min (120 min后)，表明氯仿可溶性部位的活性较其他样品强。在孔交叉试验中也观察到类似的数据，120 min后标准、CME、CHF和AQF的每分钟运动次数分别为3.60次、5.56次、4.77次和7.99次。在EPM测试中，CME显示小鼠进入EPM张开臂的百分比以及在张开臂中花费的时间百分比显着降低。结果表明，CHF对运动活性的抑制作用明显优于甲醇和水溶液组分。这些发现将有助于生物测定指导分离负责细胞毒性和镇静活性的活性成分。孟加拉药学杂志24(2):105-110,2021
{"title":"Cytotoxicity and Sedative Activity of Steam Bark of Dillenia indica L.","authors":"Mst Jasmin Akter, Sekendar Ali, Iffat Hasnin, N. A. Khatune, A. Rahman","doi":"10.3329/BPJ.V24I2.54708","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54708","url":null,"abstract":"The study aims to assess the cytotoxic activity of the methanolic extract (CME) and various fractions from the bark of Dillenia indica L (Family: Dilleniaceae) using brine shrimp lethality bioassay and sedative activities using hole cross, open field, and elevated-plus maze (EPM) test in Swiss albino mice. In brine shrimp assay, the LC50 for CME, pet-ether (PETF), chloroform (CHF) and aqueous (AQF) fraction were found to be 110, 24.55, 85 and 14.45 μg/ml, respectively, indicating significant cytotoxicity of PETF and AQF when compared to the standard vincristine sulfate (7.5 μg/ml). In open field test, the number of movements per min (after 120 min) was 40.90, 12.43, 5.45, 3.66, and 29.74 for control, standard diazepam, CME, CHF and AQF, respectively, indicating strong activity of the chloroform soluble fraction compared to the other test samples of D. indica. Similar data was observed in hole cross test where the number of movements per minute after 120 min were 3.60, 5.56, 4.77, and 7.99 for the standard, CME, CHF and AQF, respectively. In EPM test, the CME showed a significant decreased percentage of entries of mice into the open arms of EPM as well as the percentage of time spent in the open arms. The result indicates that the CHF significantly suppressed the locomotor activity than that of methanol and aqueous fractions. These findings will be helpful for bioassay-guided isolation of active principles responsible for cytotoxicity and sedative activities. \u0000Bangladesh Pharmaceutical Journal 24(2): 105-110, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74423628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anika Tabassum Obonti, Safaet Alam, Taslima Binte Kamal, A. Zaman, H. Hasnat, Tanoy Saha, A. Islam
Malaria is a serious illness resulted from parasites that are communicated to people through the bites of infected female Anopheles mosquitoes. Malaria is still in a worrying trend, particularly in tropical and subtropical climates although it is curable and preventable. In spite of a noteworthy abetment in incidence and death rates caused by malaria, even in 2017, a big number of people (219 million) have been affected by it along with 435 thousand confirmed death cases. Though a lot of synthetic drugs have been commercialized to treat malaria, those are compromised with some serious side effects. On the contrary, plant sources are always getting a big focus to develop novel and effective therapeutics in the treatment of different ailments i.e. quinine and artemisinin to treat malarial complications. The usage of herbal plants against malaria has also a very ancient root. Several families of plant species have showed potential antimalarial activities in previous research works. In this review work, families of these plants have been compiled so that prospective researchers can find a hint to discover more effective and safer plant-derived therapeutic options against malaria. Bangladesh Pharmaceutical Journal 24(2): 180-193, 2021
{"title":"Prospective Plants with Corroborated Antimalarial Actions: A Review","authors":"Anika Tabassum Obonti, Safaet Alam, Taslima Binte Kamal, A. Zaman, H. Hasnat, Tanoy Saha, A. Islam","doi":"10.3329/BPJ.V24I2.54716","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54716","url":null,"abstract":"Malaria is a serious illness resulted from parasites that are communicated to people through the bites of infected female Anopheles mosquitoes. Malaria is still in a worrying trend, particularly in tropical and subtropical climates although it is curable and preventable. In spite of a noteworthy abetment in incidence and death rates caused by malaria, even in 2017, a big number of people (219 million) have been affected by it along with 435 thousand confirmed death cases. Though a lot of synthetic drugs have been commercialized to treat malaria, those are compromised with some serious side effects. On the contrary, plant sources are always getting a big focus to develop novel and effective therapeutics in the treatment of different ailments i.e. quinine and artemisinin to treat malarial complications. The usage of herbal plants against malaria has also a very ancient root. Several families of plant species have showed potential antimalarial activities in previous research works. In this review work, families of these plants have been compiled so that prospective researchers can find a hint to discover more effective and safer plant-derived therapeutic options against malaria. \u0000Bangladesh Pharmaceutical Journal 24(2): 180-193, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81587446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fajilatun Nesa, M. Shoeb, Mazharul Islam, N. Islam
Syzygium jambos L. belonging to the family Myrtaceae has a long history of using as a dietary fruit and folklore medicine. Investigation of this fruit was carried out to evaluate the different chemical properties and biological activities. The moisture and ash content of the fruit sample were calculated as 86.88 ± 0.61% and 0.29±0.02%, respectively. Dried powder of the fruit was extracted successively with nhexane, dichloromethane (DCM) and methanol (MeOH). UV-Visible and FT-IR spectral analyses confirmed the presence of unsaturated carboxylic acid in n-hexane, unsaturated ester in DCM and a diketone in MeOH extracts. Cytotoxicity assay of different extracts was carried out against HeLa and Vero cell lines and no extract was found to be cytotoxic. Total phenolic contents of the n-hexane, DCM and MeOH extracts were 15.39 ± 0.24, 31.32 ± 0.25 and 42.19 ± 0.16 mg gallic acid equivalent per gram of dry extract, respectively and total flavonoid content of n-hexane, DCM and MeOH extracts were 6.52 ± 0.18, 15.55 ± 0.16 and 8.36 ± 0.16 mg quercetin equivalent per gram of dry extract, respectively. This study establishes that S. jambos fruit can be a potential source of natural antioxidants. Bangladesh Pharmaceutical Journal 24(2): 111-116, 2021
{"title":"Studies of Physico-chemical Properties and Cytotoxicity of Fruits of Syzygium jambos L. against HeLa and Vero Cell Lines","authors":"Fajilatun Nesa, M. Shoeb, Mazharul Islam, N. Islam","doi":"10.3329/BPJ.V24I2.54709","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54709","url":null,"abstract":"Syzygium jambos L. belonging to the family Myrtaceae has a long history of using as a dietary fruit and folklore medicine. Investigation of this fruit was carried out to evaluate the different chemical properties and biological activities. The moisture and ash content of the fruit sample were calculated as 86.88 ± 0.61% and 0.29±0.02%, respectively. Dried powder of the fruit was extracted successively with nhexane, dichloromethane (DCM) and methanol (MeOH). UV-Visible and FT-IR spectral analyses confirmed the presence of unsaturated carboxylic acid in n-hexane, unsaturated ester in DCM and a diketone in MeOH extracts. Cytotoxicity assay of different extracts was carried out against HeLa and Vero cell lines and no extract was found to be cytotoxic. Total phenolic contents of the n-hexane, DCM and MeOH extracts were 15.39 ± 0.24, 31.32 ± 0.25 and 42.19 ± 0.16 mg gallic acid equivalent per gram of dry extract, respectively and total flavonoid content of n-hexane, DCM and MeOH extracts were 6.52 ± 0.18, 15.55 ± 0.16 and 8.36 ± 0.16 mg quercetin equivalent per gram of dry extract, respectively. This study establishes that S. jambos fruit can be a potential source of natural antioxidants. \u0000Bangladesh Pharmaceutical Journal 24(2): 111-116, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82331338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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