Kazi Milenur Rahman Prattay, Riaz Uddin, Diponkor Kumar Shill, Rajib Das, Md Raihan Sarkar, K. Sikdar
Despite being a common public health problem, there are few population-based research available to learn about the epidemiology and management of gastrointestinal reflux disease (GERD) in Bangladesh. The tenacity of this study was to investigate the prevalence, potential predisposing factors, clinical representation, therapeutic management of GERD among the young Bangladeshi population along with their beliefs regarding the disease. A descriptive cross-sectional study was conducted during 13th June 2022 to 10th December 2022 among 925 individuals (16-35 years of age) from various parts of Bangladesh. A standardized online questionnaire in both English and the local language (Bengali) was utilized to collect all the desired data that were analyzed using either Microsoft Excel 2019 or, IBM SPSS Statistics, v26.0. The prevalence of GERD was 55.7% which was not significantly associated with different sociodemographic parameters. However, family history (Odds ratio (OR) = 2.512), irregular meal (OR = 1.527) and spicy/junk food (OR = 1.495) were significantly associated with GERD prevalence in binary logistic regression analysis. Heart burn (94.0%) and regurgitation (83.3%) were the major symptoms observed and the average number of symptoms was higher in patients with relevant family history (p < 0.0005). Omeprazole (42.5%) was the most used medication to treat GERD followed by other proton pump inhibitors and H2 blockers. Self-medication was practiced by 52.6% of the patients which was associated with duration of treatment (p < 0.0005). The study has found a high prevalence of GERD in Bangladesh. Family history, irregular meal and spicy/junk foods have been identified as potential risk factors and only half the participants had the right belief regarding the effectiveness of lifestyle modification against GERD. Further cohort studies are advised to solidify the findings of this study. Bangladesh Pharmaceutical Journal 27(1): 19-36, 2024 (January)
{"title":"Community-based Descriptive Cross-sectional Study on Prevalence, Clinical Manifestation, Beliefs and Management Approach of Gastroesophageal Reflux Disease (GERD) Among Young Bangladeshi Population","authors":"Kazi Milenur Rahman Prattay, Riaz Uddin, Diponkor Kumar Shill, Rajib Das, Md Raihan Sarkar, K. Sikdar","doi":"10.3329/bpj.v27i1.71150","DOIUrl":"https://doi.org/10.3329/bpj.v27i1.71150","url":null,"abstract":"Despite being a common public health problem, there are few population-based research available to learn about the epidemiology and management of gastrointestinal reflux disease (GERD) in Bangladesh. The tenacity of this study was to investigate the prevalence, potential predisposing factors, clinical representation, therapeutic management of GERD among the young Bangladeshi population along with their beliefs regarding the disease. A descriptive cross-sectional study was conducted during 13th June 2022 to 10th December 2022 among 925 individuals (16-35 years of age) from various parts of Bangladesh. A standardized online questionnaire in both English and the local language (Bengali) was utilized to collect all the desired data that were analyzed using either Microsoft Excel 2019 or, IBM SPSS Statistics, v26.0. The prevalence of GERD was 55.7% which was not significantly associated with different sociodemographic parameters. However, family history (Odds ratio (OR) = 2.512), irregular meal (OR = 1.527) and spicy/junk food (OR = 1.495) were significantly associated with GERD prevalence in binary logistic regression analysis. Heart burn (94.0%) and regurgitation (83.3%) were the major symptoms observed and the average number of symptoms was higher in patients with relevant family history (p < 0.0005). Omeprazole (42.5%) was the most used medication to treat GERD followed by other proton pump inhibitors and H2 blockers. Self-medication was practiced by 52.6% of the patients which was associated with duration of treatment (p < 0.0005). The study has found a high prevalence of GERD in Bangladesh. Family history, irregular meal and spicy/junk foods have been identified as potential risk factors and only half the participants had the right belief regarding the effectiveness of lifestyle modification against GERD. Further cohort studies are advised to solidify the findings of this study.\u0000Bangladesh Pharmaceutical Journal 27(1): 19-36, 2024 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"46 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferdous Alam Papry, Zasia Hossain Tishe, Md Zahidul Islam Zahid, A. Barman, M. Shill
Physical inactivity is one of the global health problems due to increased automation, moving less than before causing people to an elevated risk of developing various health conditions like obesity, hypertension, heart disease, etc. Most of the aforementioned diseases are linked to unhealthy lifestyles that are quite preventable. Although very few studies have been done related with sedentary lifestyle and its risks in Bangladesh, no study was focused on corporate professionals whom are at high health risk due to their job nature. This study therefore aims to explore the sedentary lifestyle and associated health and lifestyle related factors that might play role in the worsening of healthy life. Results of our study concluded that professionals belonging to age group between 25-29 years are most likely heading towards the risk zone of developing sedentary lifestyle associated risk according to WHO guidelines on sedentary lifestyle especially high body mass index (BMI 25 and more). Among the studied participants 78% were smokers and 21% were alcoholics. Moreover, 63% corporates reported that they could sleep 6 hour or less in a day, while 64% of the participants claimed that their stress level is high (7 to 10) in a 10 scale. Almost one fourth (24%) of the participants informed that they did not do any format of physical activity, and 26% participants were working for 5 years or more. Our data adequately pointed out some leading risk factors among the corporates that directly or indirectly provoke prospective health risks as described in numerous number of previous studies. Bangladesh Pharmaceutical Journal 27(1): 73-84, 2024 (January)
{"title":"Sedentary Lifestyle and Prospective Health Risks: A Pilot Study Among Bangladeshi Corporate Professionals","authors":"Ferdous Alam Papry, Zasia Hossain Tishe, Md Zahidul Islam Zahid, A. Barman, M. Shill","doi":"10.3329/bpj.v27i1.71157","DOIUrl":"https://doi.org/10.3329/bpj.v27i1.71157","url":null,"abstract":"Physical inactivity is one of the global health problems due to increased automation, moving less than before causing people to an elevated risk of developing various health conditions like obesity, hypertension, heart disease, etc. Most of the aforementioned diseases are linked to unhealthy lifestyles that are quite preventable. Although very few studies have been done related with sedentary lifestyle and its risks in Bangladesh, no study was focused on corporate professionals whom are at high health risk due to their job nature. This study therefore aims to explore the sedentary lifestyle and associated health and lifestyle related factors that might play role in the worsening of healthy life. Results of our study concluded that professionals belonging to age group between 25-29 years are most likely heading towards the risk zone of developing sedentary lifestyle associated risk according to WHO guidelines on sedentary lifestyle especially high body mass index (BMI 25 and more). Among the studied participants 78% were smokers and 21% were alcoholics. Moreover, 63% corporates reported that they could sleep 6 hour or less in a day, while 64% of the participants claimed that their stress level is high (7 to 10) in a 10 scale. Almost one fourth (24%) of the participants informed that they did not do any format of physical activity, and 26% participants were working for 5 years or more. Our data adequately pointed out some leading risk factors among the corporates that directly or indirectly provoke prospective health risks as described in numerous number of previous studies.\u0000Bangladesh Pharmaceutical Journal 27(1): 73-84, 2024 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"111 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139785340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Begum, Khodijatul Kubra, Rabiul Aowal, Nushrat Jahan Ema
The purpose of this present study was to explore lactic acid bacteria (LAB) from homemade kimchi. Traditionally, kimchi was made in this study at home using fresh vegetables such as cabbage, carrots, radish, green onion leaf, red pepper, garlic, ginger, salt and rice flour, and fermented for seven days. LAB were isolated using selective media and identified by macroscopic and microscopic morphological analysis and short biochemical tests such as catalase, oxidase and Kliger's iron agar (KIA) test. Probiotic potential of LAB was investigated by acid, salt, temperature tolerance and sugar including glucose, fructose, sucrose, xylose and lactose fermentation test. Four distinct single colonies were isolated from four different kimchi preparations. All isolated bacteria were identified as lactic acid bacteria and found gram positive, non-spore forming, survive in both aerobic and anaerobic condition, catalase and oxidase negative. Isolated LAB survive in both highly acidic (pH 2) and alkaline (pH 8) medium, up to 4% NaCl concentrations and at temperatures ranging from 4°C to 55°C. The isolated LAB have also ability to ferment sugars. These findings reveal that isolated LAB found suitable to survive in the environment of human gastrointestinal tract and have probiotic potential. Bangladesh Pharmaceutical Journal 27(1): 103-109, 2024 (January)
{"title":"Characterization of Lactic Acid Bacteria (LAB) Isolated from Homemade Fermented Kimchi in Bangladesh","authors":"K. Begum, Khodijatul Kubra, Rabiul Aowal, Nushrat Jahan Ema","doi":"10.3329/bpj.v27i1.71160","DOIUrl":"https://doi.org/10.3329/bpj.v27i1.71160","url":null,"abstract":"The purpose of this present study was to explore lactic acid bacteria (LAB) from homemade kimchi. Traditionally, kimchi was made in this study at home using fresh vegetables such as cabbage, carrots, radish, green onion leaf, red pepper, garlic, ginger, salt and rice flour, and fermented for seven days. LAB were isolated using selective media and identified by macroscopic and microscopic morphological analysis and short biochemical tests such as catalase, oxidase and Kliger's iron agar (KIA) test. Probiotic potential of LAB was investigated by acid, salt, temperature tolerance and sugar including glucose, fructose, sucrose, xylose and lactose fermentation test. Four distinct single colonies were isolated from four different kimchi preparations. All isolated bacteria were identified as lactic acid bacteria and found gram positive, non-spore forming, survive in both aerobic and anaerobic condition, catalase and oxidase negative. Isolated LAB survive in both highly acidic (pH 2) and alkaline (pH 8) medium, up to 4% NaCl concentrations and at temperatures ranging from 4°C to 55°C. The isolated LAB have also ability to ferment sugars. These findings reveal that isolated LAB found suitable to survive in the environment of human gastrointestinal tract and have probiotic potential.\u0000Bangladesh Pharmaceutical Journal 27(1): 103-109, 2024 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"103 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139785395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Azizur Rahman, Ikramul Hasan, Bk Sajeeb, Farhanul Islam, Saikat Mitra, Muhammad Rashedul Islam, Md Elias Al Mamun
Among many mosquito control approaches, the use of mosquito coil is popular because of its cost effectiveness and ease of use. But along with repelling mosquitoes, the burning of mosquito coils can cause severe health hazard. In mosquito coils, pyrethrin, allethrin, d-allethrin etc. are typically used as active ingredients. In this study, it was found that mosquito coil is used mostly (51%) in rural area and most of the rural people (64.7%) believed it to be beneficial as mosquito repellent as well as they are not so aware of the harmful effects of the mosquito coil (25%). Due to mosquito coil burning, the participants feel many such complications like suffocation (32.3%), eye irritation (29.2%), sneezing (13.1%) but they do not take any special measure or treatment to protect them. Rather, they mostly place the coil away from them (50%) to protect themselves after being exposed to those complications. These findings have raised a question, ― which one is more harmful: Mosquito or mosquito coil? Besides, most of the people even don’t know about the dangerous effects of mosquito coils. Although mosquito net is the most effective way to repel mosquito, 69% people do not use mosquito net due to laziness. Extensive research regarding alternative mosquito repelling strategy and safe use of mosquito coil is urgently needed in the context of countries like Bangladesh. Bangladesh Pharmaceutical Journal 27(1): 92-102, 2024 (January)
{"title":"Practice and Perception Analysis of Mosquito Coil Usages in Bangladesh","authors":"Md Azizur Rahman, Ikramul Hasan, Bk Sajeeb, Farhanul Islam, Saikat Mitra, Muhammad Rashedul Islam, Md Elias Al Mamun","doi":"10.3329/bpj.v27i1.71159","DOIUrl":"https://doi.org/10.3329/bpj.v27i1.71159","url":null,"abstract":"Among many mosquito control approaches, the use of mosquito coil is popular because of its cost effectiveness and ease of use. But along with repelling mosquitoes, the burning of mosquito coils can cause severe health hazard. In mosquito coils, pyrethrin, allethrin, d-allethrin etc. are typically used as active ingredients. In this study, it was found that mosquito coil is used mostly (51%) in rural area and most of the rural people (64.7%) believed it to be beneficial as mosquito repellent as well as they are not so aware of the harmful effects of the mosquito coil (25%). Due to mosquito coil burning, the participants feel many such complications like suffocation (32.3%), eye irritation (29.2%), sneezing (13.1%) but they do not take any special measure or treatment to protect them. Rather, they mostly place the coil away from them (50%) to protect themselves after being exposed to those complications. These findings have raised a question, ― which one is more harmful: Mosquito or mosquito coil? Besides, most of the people even don’t know about the dangerous effects of mosquito coils. Although mosquito net is the most effective way to repel mosquito, 69% people do not use mosquito net due to laziness. Extensive research regarding alternative mosquito repelling strategy and safe use of mosquito coil is urgently needed in the context of countries like Bangladesh.\u0000Bangladesh Pharmaceutical Journal 27(1): 92-102, 2024 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"126 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139845699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheikh Alma, Umme Tamima Tamme, Asif Uj Jaman, Md. Nasir Uddin, S. Shahriar, M. Rashid
Canna indica L., a perennial plant known as Indian shot and African arrowroot, is a member of the family Cannaceae. Historically, this plant was used to treat menstrual cramps, diarrhea and dysentery. The purpose of this investigation was to assess the antioxidant, cytotoxic, thrombolytic and membrane stabilizing activities of the methanol extract of C. indica leaf and its organic soluble fractions. The DPPH free radical scavenging method and the total phenolic content determination were utilized to evaluate the antioxidant capacity, whereas the brine shrimp lethality bioassay was implemented to study the cytotoxic potential. The ability of the extractives to prevent the hemolysis of red blood cells (RBC) in response to the application of heat and hypotonic solutions was used to estimate of their membrane stabilizing potential. In all of these experiments, the methanolic leaf extract (ME) displayed moderate activity, while the petroleum ether soluble fraction (PSF) and the dichloromethane soluble fraction (DSF) demonstrated the most promising antioxidant and cytotoxic activities among the extractives. However, the strongest thrombolytic and membrane stabilizing activities were observed by the chloroform soluble fraction (CSF). Additional research may be necessary to determine which phytoconstituents are most likely to be responsible for the aforementioned qualities. Bangladesh Pharmaceutical Journal 26(2): 162-166, 2023 (July)
{"title":"Evaluation of Antioxidant, Cytotoxic, Thrombolytic and Membrane Stabilizing Activities of Canna indica L. Leaves (Family: Cannaceae)","authors":"Sheikh Alma, Umme Tamima Tamme, Asif Uj Jaman, Md. Nasir Uddin, S. Shahriar, M. Rashid","doi":"10.3329/bpj.v26i2.67806","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67806","url":null,"abstract":"Canna indica L., a perennial plant known as Indian shot and African arrowroot, is a member of the family Cannaceae. Historically, this plant was used to treat menstrual cramps, diarrhea and dysentery. The purpose of this investigation was to assess the antioxidant, cytotoxic, thrombolytic and membrane stabilizing activities of the methanol extract of C. indica leaf and its organic soluble fractions. The DPPH free radical scavenging method and the total phenolic content determination were utilized to evaluate the antioxidant capacity, whereas the brine shrimp lethality bioassay was implemented to study the cytotoxic potential. The ability of the extractives to prevent the hemolysis of red blood cells (RBC) in response to the application of heat and hypotonic solutions was used to estimate of their membrane stabilizing potential. In all of these experiments, the methanolic leaf extract (ME) displayed moderate activity, while the petroleum ether soluble fraction (PSF) and the dichloromethane soluble fraction (DSF) demonstrated the most promising antioxidant and cytotoxic activities among the extractives. However, the strongest thrombolytic and membrane stabilizing activities were observed by the chloroform soluble fraction (CSF). Additional research may be necessary to determine which phytoconstituents are most likely to be responsible for the aforementioned qualities.\u0000Bangladesh Pharmaceutical Journal 26(2): 162-166, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"2009 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78900128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Hasnat, Suriya Akter Shompa, Fahmida Tasnim Richi, M. M. Islam, Mehedi Hasan Suman, N. U. Ahmed, S. Ashrafi, A. Zaman, Tanoy Saha, Md. Ashraful Islam, Safaet Alam
Diabetes mellitus (DM) is a condition characterized by excessive blood sugar levels, which have recently reached the level of a pandemic. There are various side effects of each drug to treat this condition. Molecular docking is a modern concept for computer-aided drug designing. Using this technique several potential antidiabetic phytocompounds are evaluated against three target receptors including GLUT-3, PPARγ and α-amylase related to DM. These compounds' ADMET and drug-likeliness characteristics have also been assessed to determine potential drug candidacy. Most of the compounds exhibited magnificent binding affinity against these targets, especially compounds 30 and 27 have shown great affinity against GLUT-3 with values of -11.2 and -10.2 Kcal/mol respectively. Where compound 37 has the highest binding affinity (-9.1 Kcal/mol) against PPARγ. Also, with values of -11.6 and -10.8 Kcal/mol respectively compounds 38 and 12 notably bind with α-amylase. Moreover, all of these compounds have magnificent results on ADMET and drug-likeliness studies, in particular, compound 29 has shown high affinity against all of these receptors, explored 0.55% bioavailability score, no toxicity and high absorptivity. Although these compounds have undergone a preliminary drug discovery study, more research must be done to determine their precise mechanism of action against DM. Bangladesh Pharmaceutical Journal 26(2): 167-184, 2023 (July)
{"title":"Bioactive Secondary Metabolites to Combat Diabetic Complications: Evidenced from in Silico Study","authors":"H. Hasnat, Suriya Akter Shompa, Fahmida Tasnim Richi, M. M. Islam, Mehedi Hasan Suman, N. U. Ahmed, S. Ashrafi, A. Zaman, Tanoy Saha, Md. Ashraful Islam, Safaet Alam","doi":"10.3329/bpj.v26i2.67807","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67807","url":null,"abstract":"Diabetes mellitus (DM) is a condition characterized by excessive blood sugar levels, which have recently reached the level of a pandemic. There are various side effects of each drug to treat this condition. Molecular docking is a modern concept for computer-aided drug designing. Using this technique several potential antidiabetic phytocompounds are evaluated against three target receptors including GLUT-3, PPARγ and α-amylase related to DM. These compounds' ADMET and drug-likeliness characteristics have also been assessed to determine potential drug candidacy. Most of the compounds exhibited magnificent binding affinity against these targets, especially compounds 30 and 27 have shown great affinity against GLUT-3 with values of -11.2 and -10.2 Kcal/mol respectively. Where compound 37 has the highest binding affinity (-9.1 Kcal/mol) against PPARγ. Also, with values of -11.6 and -10.8 Kcal/mol respectively compounds 38 and 12 notably bind with α-amylase. Moreover, all of these compounds have magnificent results on ADMET and drug-likeliness studies, in particular, compound 29 has shown high affinity against all of these receptors, explored 0.55% bioavailability score, no toxicity and high absorptivity. Although these compounds have undergone a preliminary drug discovery study, more research must be done to determine their precise mechanism of action against DM.\u0000Bangladesh Pharmaceutical Journal 26(2): 167-184, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78007100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Islam, M. A. Rahman, I. Imtiaz Ahmed, M. S. Hossain
Liver complication is a major concern in the world. Finding out a new way to combat various liver diseases is very much required. Ginger has been reported to have hepato-protective activity. Here we aimed to formulate an oil-based (self-micro emulsifying) powder to improve the hepatoprotective activity of dry powder of Zingiber officinale (Ginger). Four different formulations of self-microemulsifying dry powder were prepared by mixing with different excipients. The formulated powder was characterized for the angle of repose, Hausner ratio and compressibility index. The hepato-protective activity of the formulated powder was evaluated in vivo. All of the parameters tested for powder characterization showed a good response in terms of flow property and compressibility. Formulated powder exhibited a significant decrease (p<0.05) in hepatic enzymes like aspartate transaminase (AST) and alanine transaminase (ALT) in carbon tetrachloride (CCl4) induced hepatotoxic mice compared to fresh ginger powder group which indicates the enhanced hepatoprotective activity of prepared self-micro emulsifying power in hepatotoxicity. Bangladesh Pharmaceutical Journal 26(2): 125-133, 2023 (July)
{"title":"Formulation of Self Micro-Emulsifying Dry Powder of Zingiber officinale (Rhizome) and Its Effect on Hepatoprotective Activity in Mice Model","authors":"M. Islam, M. A. Rahman, I. Imtiaz Ahmed, M. S. Hossain","doi":"10.3329/bpj.v26i2.67801","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67801","url":null,"abstract":"Liver complication is a major concern in the world. Finding out a new way to combat various liver diseases is very much required. Ginger has been reported to have hepato-protective activity. Here we aimed to formulate an oil-based (self-micro emulsifying) powder to improve the hepatoprotective activity of dry powder of Zingiber officinale (Ginger). Four different formulations of self-microemulsifying dry powder were prepared by mixing with different excipients. The formulated powder was characterized for the angle of repose, Hausner ratio and compressibility index. The hepato-protective activity of the formulated powder was evaluated in vivo. All of the parameters tested for powder characterization showed a good response in terms of flow property and compressibility. Formulated powder exhibited a significant decrease (p<0.05) in hepatic enzymes like aspartate transaminase (AST) and alanine transaminase (ALT) in carbon tetrachloride (CCl4) induced hepatotoxic mice compared to fresh ginger powder group which indicates the enhanced hepatoprotective activity of prepared self-micro emulsifying power in hepatotoxicity.\u0000Bangladesh Pharmaceutical Journal 26(2): 125-133, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"391 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76451990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raisa S. Habib, Md. Rafat Tahsin, F. Aktar, J. A. Chowdhury, A. A. Chowdhury, Shaila Kabir, Md. Shah Amran
Chronic diseases are serious health concern all over the world and these are adding immense sufferings to millions of people. These remain persistent in one’s life and have long lasting effects on human life. Plant-based therapies can act as potential remedies to manage or cure these diseases with fewer, if not, no adverse effects and at a reasonable cost than the commercially available modern drugs. Furthermore, the constituents can be genetically modified to make them therapeutically effective against chronic diseases like diabetes, chronic inflammatory skin disease, chronic kidney disease, hypertension, cancer, ischemic heart disease and so on. Bombax ceiba Linn. is a tall, deciduous, multipurpose, miraculous tree that has numerous phytochemical constituents such as quercetin, carotenoids, β-sitosterol, α-tocopherol etc. along with shamimin, a novel compound that can help to treat chronic disorders. It has a long history for its medicinal uses. It is even highly regarded among aboriginal peoples for the remedy of various human and animal illnesses. Bangladesh Pharmaceutical Journal 26(2): 219-229, 2023 (July)
{"title":"Review on Bombax ceiba Linn.: A Potential Remedy for Chronic Diseases","authors":"Raisa S. Habib, Md. Rafat Tahsin, F. Aktar, J. A. Chowdhury, A. A. Chowdhury, Shaila Kabir, Md. Shah Amran","doi":"10.3329/bpj.v26i2.67812","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67812","url":null,"abstract":"Chronic diseases are serious health concern all over the world and these are adding immense sufferings to millions of people. These remain persistent in one’s life and have long lasting effects on human life. Plant-based therapies can act as potential remedies to manage or cure these diseases with fewer, if not, no adverse effects and at a reasonable cost than the commercially available modern drugs. Furthermore, the constituents can be genetically modified to make them therapeutically effective against chronic diseases like diabetes, chronic inflammatory skin disease, chronic kidney disease, hypertension, cancer, ischemic heart disease and so on. Bombax ceiba Linn. is a tall, deciduous, multipurpose, miraculous tree that has numerous phytochemical constituents such as quercetin, carotenoids, β-sitosterol, α-tocopherol etc. along with shamimin, a novel compound that can help to treat chronic disorders. It has a long history for its medicinal uses. It is even highly regarded among aboriginal peoples for the remedy of various human and animal illnesses. \u0000Bangladesh Pharmaceutical Journal 26(2): 219-229, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88957016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Severe acute respiratory syndrome or SARS-Cov-2 is a global pandemic causing over 6.5 million deaths worldwide. As a part of the global village, Bangladesh is also heavily affected with more than 29,000 deaths in those two years of pandemic. Though the severity and mortality rate are not so high compared to the other countries, Bangladesh also faced many difficulties combating the mutated and newer types of the Covid-19. The evolution and phylogenetic study of the virus is one of those key areas to focus in order to understand the nature of virus, its mutation pattern and gene prediction. This study investigates the evolutionary links among the older and newly emerged SARS‐Cov‐2 variants. In this study, the entire genome sequences of SARS‐Cov‐2 variants were obtained, aligned using muscle alignment, pairwise comparison was computed, differences, gaps and mutations were noted. The phylogenetics of different types of covid-19 variants were determined using a variety of evolutionary substitution models. The ultrametric and metric clustering methods, such as UPGMA and neighbor‐joining (NJ), using nucleotide substitution models allowed the inclusion of nucleotide transitions and transversions as Kimura 80 models. The findings revealed that Omicron variant forms a new monophyletic clade that is distant from other SARS‐Cov‐2 variants but surprisingly in proximity to the alpha variant, which was actually dominant in the early stage of pandemic. This finding also indicates that the omicron variant might have been there for a while, hiding the virulence and later becomes the variant of concern in the latest wave of the pandemic. This may pave the way for new researchers to find proper insight of different variants of Bangladesh in treatment plan and vaccine designing. Bangladesh Pharmaceutical Journal 26(2): 204-211, 2023 (July)
{"title":"Mutational and Phylogenetic Analyses of SARS-Cov-2: Bangladesh Perspective","authors":"BM Fahim Faisal, Md. Selim Reza","doi":"10.3329/bpj.v26i2.67810","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67810","url":null,"abstract":"Severe acute respiratory syndrome or SARS-Cov-2 is a global pandemic causing over 6.5 million deaths worldwide. As a part of the global village, Bangladesh is also heavily affected with more than 29,000 deaths in those two years of pandemic. Though the severity and mortality rate are not so high compared to the other countries, Bangladesh also faced many difficulties combating the mutated and newer types of the Covid-19. The evolution and phylogenetic study of the virus is one of those key areas to focus in order to understand the nature of virus, its mutation pattern and gene prediction. This study investigates the evolutionary links among the older and newly emerged SARS‐Cov‐2 variants. In this study, the entire genome sequences of SARS‐Cov‐2 variants were obtained, aligned using muscle alignment, pairwise comparison was computed, differences, gaps and mutations were noted. The phylogenetics of different types of covid-19 variants were determined using a variety of evolutionary substitution models. The ultrametric and metric clustering methods, such as UPGMA and neighbor‐joining (NJ), using nucleotide substitution models allowed the inclusion of nucleotide transitions and transversions as Kimura 80 models. The findings revealed that Omicron variant forms a new monophyletic clade that is distant from other SARS‐Cov‐2 variants but surprisingly in proximity to the alpha variant, which was actually dominant in the early stage of pandemic. This finding also indicates that the omicron variant might have been there for a while, hiding the virulence and later becomes the variant of concern in the latest wave of the pandemic. This may pave the way for new researchers to find proper insight of different variants of Bangladesh in treatment plan and vaccine designing.\u0000Bangladesh Pharmaceutical Journal 26(2): 204-211, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73274383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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