M. Alam, Md Sakib Rayhan, Arnob Ghosh, Asm Monjur Al Hossain
Numerous clinical and experimental studies have shown that individuals with a variety of orthopedic diseases can get benefit from the undenatured form of type II collagen (UC-II). It has proved its efficacy and long lasting effectiveness for several orthopedic patients throughout different countries in the world. But in Bangladesh it is not frequently prescribed yet. Therefore, we made the decision to conduct a survey-based study to determine the number of patients prescribed with UC-II under which pathological conditions and to what extent they have got relief from their joint associated ailments. To conduct the study, we visited the orthopedic department of various hospitals in Bangladesh and with consent from patients we collected pictures of prescriptions as well as got overview regarding their complications. We gathered photographs of 252 prescriptions from orthopedic department patients, among which only 31 patients were prescribed with UC-II. According to this study, 40.47 , 32.54 , 15.47 , 9.12 and 2.38 % of patients were over the age group of 60 , 50 , 40 , 30 and 20 - years respectively. We found that a range of individuals with various orthopedic problems such as osteoarthritis, spondylosis, right tibial plateau, paresthesia in right upper limb and various bone fractures were advised with UC-II. However, we discovered only in 12.30% of prescriptions that the doctors prescribed UC-II, indicating this is a less common practice in Bangladesh in spite of its huge potential to recover joint pain associated complications. Bangladesh Pharmaceutical Journal 26(2): 157-161, 2023 (July)
{"title":"A Cross-sectional Study on the Prescription Pattern of Undenatured Collagen-II in Bangladeshi Patients","authors":"M. Alam, Md Sakib Rayhan, Arnob Ghosh, Asm Monjur Al Hossain","doi":"10.3329/bpj.v26i2.67805","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67805","url":null,"abstract":"Numerous clinical and experimental studies have shown that individuals with a variety of orthopedic diseases can get benefit from the undenatured form of type II collagen (UC-II). It has proved its efficacy and long lasting effectiveness for several orthopedic patients throughout different countries in the world. But in Bangladesh it is not frequently prescribed yet. Therefore, we made the decision to conduct a survey-based study to determine the number of patients prescribed with UC-II under which pathological conditions and to what extent they have got relief from their joint associated ailments. To conduct the study, we visited the orthopedic department of various hospitals in Bangladesh and with consent from patients we collected pictures of prescriptions as well as got overview regarding their complications. We gathered photographs of 252 prescriptions from orthopedic department patients, among which only 31 patients were prescribed with UC-II. According to this study, 40.47 , 32.54 , 15.47 , 9.12 and 2.38 % of patients were over the age group of 60 , 50 , 40 , 30 and 20 - years respectively. We found that a range of individuals with various orthopedic problems such as osteoarthritis, spondylosis, right tibial plateau, paresthesia in right upper limb and various bone fractures were advised with UC-II. However, we discovered only in 12.30% of prescriptions that the doctors prescribed UC-II, indicating this is a less common practice in Bangladesh in spite of its huge potential to recover joint pain associated complications.\u0000Bangladesh Pharmaceutical Journal 26(2): 157-161, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86823171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Litsea deccanensis Gamble. (Family: Lauraceae) is used traditionally for sprained or swollen joints such as ankles or knee. Still, there is no report for its analgesic activity, therefore the present study was aimed to evaluate analgesic activity of the crude methanolic extract of L. deccanensis (MELD) bark in various mice models. Acetic acid-induced writhing, Eddy’s hot plate and formalin induced paw licking tests were performed to evaluate the pain reducing/relieving effects. In acetic acid-induced writhing model, MELD showed significant reduction of squirming (p < 0.001, p < 0.01 and p < 0.05) in a dose dependent manner as compared to control. In the heat induced pain model (Eddy’s hot plate method), MELD showed a slight increment of the latency time for the initiation of the reaction in the experimental animals, that revealed a moderate analgesic activity of MELD when compared to control group, but the results were insignificant. Whereas, in the formalin induced pain model, the reaction time was decreased significantly (p < 0.05) with the increment of doses for the studied plant extract (MELD) as well as standard in the late phase (20-30 min) of the study. So, the present study concluded a significant reduction of acetic acid-induced squirming or writhing, and formalin induced biting or licking in mice, provided us the evidence of having pain reducing potential. Bangladesh Pharmaceutical Journal 26(2): 144-149, 2023 (July)
{"title":"Analgesic Activity of Methanolic Extract of Litsea deccanensis Gamble Bark in Mice Model","authors":"I. Bulbul, M. R. Haque, M. Rashid","doi":"10.3329/bpj.v26i2.67803","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67803","url":null,"abstract":"Litsea deccanensis Gamble. (Family: Lauraceae) is used traditionally for sprained or swollen joints such as ankles or knee. Still, there is no report for its analgesic activity, therefore the present study was aimed to evaluate analgesic activity of the crude methanolic extract of L. deccanensis (MELD) bark in various mice models. Acetic acid-induced writhing, Eddy’s hot plate and formalin induced paw licking tests were performed to evaluate the pain reducing/relieving effects. In acetic acid-induced writhing model, MELD showed significant reduction of squirming (p < 0.001, p < 0.01 and p < 0.05) in a dose dependent manner as compared to control. In the heat induced pain model (Eddy’s hot plate method), MELD showed a slight increment of the latency time for the initiation of the reaction in the experimental animals, that revealed a moderate analgesic activity of MELD when compared to control group, but the results were insignificant. Whereas, in the formalin induced pain model, the reaction time was decreased significantly (p < 0.05) with the increment of doses for the studied plant extract (MELD) as well as standard in the late phase (20-30 min) of the study. So, the present study concluded a significant reduction of acetic acid-induced squirming or writhing, and formalin induced biting or licking in mice, provided us the evidence of having pain reducing potential.\u0000Bangladesh Pharmaceutical Journal 26(2): 144-149, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86594529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Omar Ali, N. A. Khatune, A. Alam, Md Aziz Abdur Rahman
Lippia alba (Mill.) (Family: Verbenaceae) is widely known due to both ethnobotanical uses and chemical diversity. The present work was designated to determine the antimicrobial and cytotoxic activities of the aqueous ethanolic extract and various fractions of this plant. The whole plant was made into coarse powder and was extracted with 5% aqueous ethanol. The concentrated ethanolic extract (abbreviated as LAE) was successively partitioned with n-hexane (LAH), chloroform (LAC), ethyl acetate (LAA), and the remaining part was designated as water (LAQ). The antimicrobial and cytotoxic activities of extract and all these fractions were evaluated in vitro using disc diffusion technique and brine shrimp (Artemia salina) lethality assay, respectively. In antimicrobial assay, five Gram-positive and five Gram-negative bacteria and standard antibiotic ciprofloxacin (10 μg/disc) were used. All the samples were tested at four concentrations (200, 400, 600 and 800 μg/disc). Our study showed that the extractive and different fractions of L. alba had antibacterial activity against all the tested bacteria except Pseudomonas aeruginosa. Among the extractives, LAE and LAH had significant antibacterial activity when compared to standard ciprofloxacin. The zone of inhibition of LAE and LAH were found to be 14.4, 24.4, 13.4, 15.2, 18.5, 24.1, 16.1, 23.5, 23.2 and 14.5, 20.1, 12.5, 17.1, 17.5, 20.1, 12.5, 19.4, and 18.16 mm against Bacillus cereus, Staphylococcus aureus, Streptococcus-β- haemolyticus, Bacillus subtilis, Sarcina lutea, Escherichia coli, Klebsiella pneumonia, Salmonella typhi and Shigella dysenteriae, respectively, at 800 μg/disc. The median lethal concentration (LC50) in brine shrimp lethality bioassay was determined by extrapolation from graph and the values were found to be 41.9, 23.9, 21.3, 88.7, 6.7 and 7.5 μg/ml for LAQ, LAH, LAC, LAA, LAE and standard vincristine sulfate, respectively. In the study, different mortality rate was observed at different concentration and all the samples showed positive response, indicating the presence of cytotoxic components in L. alba. Phytochemical screening revealed that L. alba contains saponins, tannins, glycosides, steroids, alkaloids, terpenoids and flavonoids. The results of the study indicate that L. alba might be a good source of potent antibiotic and anticancer drugs. Bangladesh Pharmaceutical Journal 26(2): 150-156, 2023 (July)
{"title":"In vitro Antibacterial and Cytotoxic Activities of Various Fractions of Lippia alba (Mill.)","authors":"Md. Omar Ali, N. A. Khatune, A. Alam, Md Aziz Abdur Rahman","doi":"10.3329/bpj.v26i2.67804","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67804","url":null,"abstract":"Lippia alba (Mill.) (Family: Verbenaceae) is widely known due to both ethnobotanical uses and chemical diversity. The present work was designated to determine the antimicrobial and cytotoxic activities of the aqueous ethanolic extract and various fractions of this plant. The whole plant was made into coarse powder and was extracted with 5% aqueous ethanol. The concentrated ethanolic extract (abbreviated as LAE) was successively partitioned with n-hexane (LAH), chloroform (LAC), ethyl acetate (LAA), and the remaining part was designated as water (LAQ). The antimicrobial and cytotoxic activities of extract and all these fractions were evaluated in vitro using disc diffusion technique and brine shrimp (Artemia salina) lethality assay, respectively. In antimicrobial assay, five Gram-positive and five Gram-negative bacteria and standard antibiotic ciprofloxacin (10 μg/disc) were used. All the samples were tested at four concentrations (200, 400, 600 and 800 μg/disc). Our study showed that the extractive and different fractions of L. alba had antibacterial activity against all the tested bacteria except Pseudomonas aeruginosa. Among the extractives, LAE and LAH had significant antibacterial activity when compared to standard ciprofloxacin. The zone of inhibition of LAE and LAH were found to be 14.4, 24.4, 13.4, 15.2, 18.5, 24.1, 16.1, 23.5, 23.2 and 14.5, 20.1, 12.5, 17.1, 17.5, 20.1, 12.5, 19.4, and 18.16 mm against Bacillus cereus, Staphylococcus aureus, Streptococcus-β- haemolyticus, Bacillus subtilis, Sarcina lutea, Escherichia coli, Klebsiella pneumonia, Salmonella typhi and Shigella dysenteriae, respectively, at 800 μg/disc. The median lethal concentration (LC50) in brine shrimp lethality bioassay was determined by extrapolation from graph and the values were found to be 41.9, 23.9, 21.3, 88.7, 6.7 and 7.5 μg/ml for LAQ, LAH, LAC, LAA, LAE and standard vincristine sulfate, respectively. In the study, different mortality rate was observed at different concentration and all the samples showed positive response, indicating the presence of cytotoxic components in L. alba. Phytochemical screening revealed that L. alba contains saponins, tannins, glycosides, steroids, alkaloids, terpenoids and flavonoids. The results of the study indicate that L. alba might be a good source of potent antibiotic and anticancer drugs.\u0000Bangladesh Pharmaceutical Journal 26(2): 150-156, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91083228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanzina Binta Enam, Silvia Afrin, Hasan Mahmud Reza, M. Shill
Emergency obstetric care (EmOC) has dramatically lowered the maternal death rate in Bangladesh since the early 1990s. Rising caesarean section rates over the past ten years have had an impact on the nation's economy in addition to other signs of better mother care. According to demographic and health surveys, caesarean section rates increased from 3.5% in 2004 to 23% in 2014. Women who become pregnant after 35 years, live in cities, have a higher level of education and frequently use antenatal services have a greater average annual rate of prevalence in caesarean sections. The objective was to assess the indications and the trends of caesarean sections done over a two-month period. The study of prevalence and determinants of caesarean section was conducted in a renowned private hospital in Dhaka. Among 197 women who were admitted to the department of obstetrics and gynecology, the number of total deliveries was 175 (89% of total admission). The indications varied a little in cases of lower abdominal pain and preeclampsia. Antepartum hemorrhage (APH) and breech have a small proportion (about 5% both). The proportion of repeated caesarean sections was 47%. Recently the indication of a maternal choice is also coming up (11%). The data were compared and analyzed to determine if the indications were significant enough for cesarean delivery. Although a caesarean section is currently a relatively safe obstetrical procedure, it is advised that the indications should be carefully evaluated in order to lower caesarean section rates. Bangladesh Pharmaceutical Journal 26(2): 195-203, 2023 (July)
{"title":"Prevalence and Determinants of Caesarean Section in a Private Health Facility: A Cross-sectional Study","authors":"Tanzina Binta Enam, Silvia Afrin, Hasan Mahmud Reza, M. Shill","doi":"10.3329/bpj.v26i2.67809","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67809","url":null,"abstract":"Emergency obstetric care (EmOC) has dramatically lowered the maternal death rate in Bangladesh since the early 1990s. Rising caesarean section rates over the past ten years have had an impact on the nation's economy in addition to other signs of better mother care. According to demographic and health surveys, caesarean section rates increased from 3.5% in 2004 to 23% in 2014. Women who become pregnant after 35 years, live in cities, have a higher level of education and frequently use antenatal services have a greater average annual rate of prevalence in caesarean sections. The objective was to assess the indications and the trends of caesarean sections done over a two-month period. The study of prevalence and determinants of caesarean section was conducted in a renowned private hospital in Dhaka. Among 197 women who were admitted to the department of obstetrics and gynecology, the number of total deliveries was 175 (89% of total admission). The indications varied a little in cases of lower abdominal pain and preeclampsia. Antepartum hemorrhage (APH) and breech have a small proportion (about 5% both). The proportion of repeated caesarean sections was 47%. Recently the indication of a maternal choice is also coming up (11%). The data were compared and analyzed to determine if the indications were significant enough for cesarean delivery. Although a caesarean section is currently a relatively safe obstetrical procedure, it is advised that the indications should be carefully evaluated in order to lower caesarean section rates.\u0000Bangladesh Pharmaceutical Journal 26(2): 195-203, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"52 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91471456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract not available Bangladesh Pharmaceutical Journal 26(2): 237-238, 2023 (July)
孟加拉药学杂志26(2):237-238,2023(7月)
{"title":"Current Health News Vol. 26(2)","authors":"M. A. Rahim","doi":"10.3329/bpj.v26i2.67981","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67981","url":null,"abstract":"Abstract not available \u0000Bangladesh Pharmaceutical Journal 26(2): 237-238, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79428768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Increased awareness of the multiple roles of RNA molecules has led to the realization that, in addition to their structural and functional roles, RNAs can be drug targets for small molecular therapy. Amikacin, a member of the aminoglycoside group of antibiotics, binds to specific sites in bacterial 16S ribosomal RNAs (rRNAs) and interferes with protein synthesis leading to cell death. Here, we used the systemic evolution of ligands by exponential enrichment (SELEX) method to isolate high affinity RNA fragments (aptamers) that bind to amikacin. After five rounds of SELEX selection, in which a linear N25 DNA template was used for the first selection cycle, the resulting RNA was cloned and sequenced. Among the 38 clones generated, five groups of sequences (groups A through E) containing nine conserved motifs were identified. The sequences of groups A and B were almost identical, indicating that the selected RNA was enriched. Subsequently, the Basic Local Alignment Search Tool program was used to search for the conserved motifs in bacterial 16S rRNA sequences. Strikingly, no sequence homology was observed, suggesting that the conserved sequences (motifs) identified in this studymay be novel target sites for amikacin. Bangladesh Pharmaceutical Journal 26(2): 134-143, 2023 (July)
{"title":"Screening of Aptamers that Bind to the Multivalent Aminoglycoside Amikacin","authors":"AHM Khurshid Alam, Yoshiko Miura, Aziz Abdur Rahman, Md Golam Sadik, Mamunur Rashid, Toshifumi Tsukahara","doi":"10.3329/bpj.v26i2.67802","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67802","url":null,"abstract":"Increased awareness of the multiple roles of RNA molecules has led to the realization that, in addition to their structural and functional roles, RNAs can be drug targets for small molecular therapy. Amikacin, a member of the aminoglycoside group of antibiotics, binds to specific sites in bacterial 16S ribosomal RNAs (rRNAs) and interferes with protein synthesis leading to cell death. Here, we used the systemic evolution of ligands by exponential enrichment (SELEX) method to isolate high affinity RNA fragments (aptamers) that bind to amikacin. After five rounds of SELEX selection, in which a linear N25 DNA template was used for the first selection cycle, the resulting RNA was cloned and sequenced. Among the 38 clones generated, five groups of sequences (groups A through E) containing nine conserved motifs were identified. The sequences of groups A and B were almost identical, indicating that the selected RNA was enriched. Subsequently, the Basic Local Alignment Search Tool program was used to search for the conserved motifs in bacterial 16S rRNA sequences. Strikingly, no sequence homology was observed, suggesting that the conserved sequences (motifs) identified in this studymay be novel target sites for amikacin. Bangladesh Pharmaceutical Journal 26(2): 134-143, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135796316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Zaman, H. Hasnat, Z. Noman, M. M. Islam, Abdullah Al Nakib, Swakshar Mukherjee, Kabbo Saha, N. U. Ahmed, S. Ashrafi, Tanoy Saha, Md. Ashraful Islam, Safaet Alam
p-coumaric acid, commonly referred to as 4-hydroxycinnamic acid, is a phenolic acid, which has been subjected to much research in recognition of its beneficial properties against several diseases and its widespread distribution in the plant kingdom. This compound can be found in the free-state or coupled with other molecules in nature. It has demonstrated prospective pharmacological effects including antiproliferative, nephroprotective, neuroprotective, antioxidant and antimicrobial effects in addition to other biological properties through numerous in vivo, in vitro and clinical studies. This review reported a short summary on p-coumaric acid to provide fundamental information in its biosynthesis, plant sources, and pharmacological effects which may help in future research and development of novel therapeutics. Bangladesh Pharmaceutical Journal 26(2): 185-194, 2023 (July)
{"title":"Exploring Pharmacological Potentials of p-Coumaric Acid: A Prospective Phytochemical for Drug Discovery","authors":"A. Zaman, H. Hasnat, Z. Noman, M. M. Islam, Abdullah Al Nakib, Swakshar Mukherjee, Kabbo Saha, N. U. Ahmed, S. Ashrafi, Tanoy Saha, Md. Ashraful Islam, Safaet Alam","doi":"10.3329/bpj.v26i2.67808","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67808","url":null,"abstract":"p-coumaric acid, commonly referred to as 4-hydroxycinnamic acid, is a phenolic acid, which has been subjected to much research in recognition of its beneficial properties against several diseases and its widespread distribution in the plant kingdom. This compound can be found in the free-state or coupled with other molecules in nature. It has demonstrated prospective pharmacological effects including antiproliferative, nephroprotective, neuroprotective, antioxidant and antimicrobial effects in addition to other biological properties through numerous in vivo, in vitro and clinical studies. This review reported a short summary on p-coumaric acid to provide fundamental information in its biosynthesis, plant sources, and pharmacological effects which may help in future research and development of novel therapeutics.\u0000Bangladesh Pharmaceutical Journal 26(2): 185-194, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81037451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayeda Mushfika Akter, Sreebash Chandra Bhowmik, Marzia Alam, S. Shahriar, Tanoy Saha, Md Saiful Islam Pathan
The purpose of the present research was to develop a fast and rapidly dissolving polymeric sublingual thin film of vildagliptin due to its simplicity of use as an alternative to oral disintegrating tablets and better compliance for diabetic patients. Nine different formulations (F1-F9) of vildagliptin sublingual films were produced using diverse concentrations of polymer A and plasticizer B by solvent casting method. Several physicochemical properties, including morphological properties, weight variation test, film thickness, folding endurance, surface pH, percentage of moisture loss, in-vitro disintegration test, in-vitro dissolution test, trinocular microscopic imaging of film, differential scanning calorimetry (DSC), FTIR study and content uniformity were evaluated. The ratios of polymer A-plasticizer B were as follows (5:1), (7:1), (7.67:1), (8:1), (8.5:1), (8.67:1, (9.67:1), (10:1), (11:1) which made the film smooth, mechanically strong and easy to peel out. Among all the different formulations, the F1 formulation showed the most significant result concerning in-vitro dissolution (98.95%) in 5 minutes, minimum disintegration time (38 sec.), less film thickness (116.67 ± .58 μm) and better folding endurance (403 times). Bangladesh Pharmaceutical Journal 26(2): 212-218, 2023 (July)
{"title":"Formulation and Estimation of Rapidly Dissolving Sublingual Thin Film of Vildagliptin","authors":"Sayeda Mushfika Akter, Sreebash Chandra Bhowmik, Marzia Alam, S. Shahriar, Tanoy Saha, Md Saiful Islam Pathan","doi":"10.3329/bpj.v26i2.67811","DOIUrl":"https://doi.org/10.3329/bpj.v26i2.67811","url":null,"abstract":"The purpose of the present research was to develop a fast and rapidly dissolving polymeric sublingual thin film of vildagliptin due to its simplicity of use as an alternative to oral disintegrating tablets and better compliance for diabetic patients. Nine different formulations (F1-F9) of vildagliptin sublingual films were produced using diverse concentrations of polymer A and plasticizer B by solvent casting method. Several physicochemical properties, including morphological properties, weight variation test, film thickness, folding endurance, surface pH, percentage of moisture loss, in-vitro disintegration test, in-vitro dissolution test, trinocular microscopic imaging of film, differential scanning calorimetry (DSC), FTIR study and content uniformity were evaluated. The ratios of polymer A-plasticizer B were as follows (5:1), (7:1), (7.67:1), (8:1), (8.5:1), (8.67:1, (9.67:1), (10:1), (11:1) which made the film smooth, mechanically strong and easy to peel out. Among all the different formulations, the F1 formulation showed the most significant result concerning in-vitro dissolution (98.95%) in 5 minutes, minimum disintegration time (38 sec.), less film thickness (116.67 ± .58 μm) and better folding endurance (403 times).\u0000Bangladesh Pharmaceutical Journal 26(2): 212-218, 2023 (July)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87583029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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