Pub Date : 2023-07-26DOI: 10.21608/bjas.2023.222626.1206
Y. Rizk, Mohamed Abdel Rhman, Dina Abdel Rhman, Ahmed Refaat
Background :In order to reduce patient pain and agitation during mechanical breathing, sedation has grown to be a crucial component of critical care management (MV). Patients' short-and long-term outcomes will alter as a result of pharmaceutical treatment that is evidence-based. The study's objective is to assess the effects of intermittent and continuous sedation on mechanically ventilated patients' length of stay in the critical care unit, frequency of adverse events, and MV duration. Methods :This randomised clinical research included 100 critically sick patients who had recently needed mechanical ventilation and were anticipated to need it for more than 24 hours. The patients were divided into two groups at random: group A, which received midazolam infusions of 1 to 8 mg/hour or 0.01 to 0.1 mg/kg/hour, titrated to the desired level of sedation, and morphine infusions of 2 to 30 mg/hour when they became agitated with a sedation agitation score (SAS) of 5 or higher. Group B, which received intermittent sedation, received morphine when they became agitated Results : When compared to patients receiving continuous sedation, those receiving intermittent sedation showed considerably greater SAS (P 0.001). Within 3 days of the follow-up, NAS was substantially different and lower when dealing with patients on intermittent sedation as opposed to those on continuous sedation (P values 0.001). When compared to patients receiving continuous sedation (median duration: 105 hr), those receiving intermittent sedation (median time: 47 hr, HR (95 percent CI): 4.686 (2.799: 7.847)), were on MV for a considerably shorter period of time with a greater HR of being extubated (P 0.001). While tracheostomy was not a predictor, the APACHE II score, being reintubated, and the incidence of delirium all significantly predicted the length of MV (coefficient: 2.361, 95 percent CI: 1.175 to 3.548, P0.001, coefficient: 28.411, 95 percent CI: 10.134 to 46.688, P=0.003, and coefficient: 21.222, 95 percent CI: 10.348 to 32.097, P0.001). Conclusions :Patients who had intermittent sedation experienced considerably lower rates of reintubation, NAS, brief MV stays, and longer hospital stays than those under continuous sedation, but significantly greater SAS.
{"title":"Intermittent versus Continuous Sedation during Mechanical Ventilation in Critically Ill Patient","authors":"Y. Rizk, Mohamed Abdel Rhman, Dina Abdel Rhman, Ahmed Refaat","doi":"10.21608/bjas.2023.222626.1206","DOIUrl":"https://doi.org/10.21608/bjas.2023.222626.1206","url":null,"abstract":"Background :In order to reduce patient pain and agitation during mechanical breathing, sedation has grown to be a crucial component of critical care management (MV). Patients' short-and long-term outcomes will alter as a result of pharmaceutical treatment that is evidence-based. The study's objective is to assess the effects of intermittent and continuous sedation on mechanically ventilated patients' length of stay in the critical care unit, frequency of adverse events, and MV duration. Methods :This randomised clinical research included 100 critically sick patients who had recently needed mechanical ventilation and were anticipated to need it for more than 24 hours. The patients were divided into two groups at random: group A, which received midazolam infusions of 1 to 8 mg/hour or 0.01 to 0.1 mg/kg/hour, titrated to the desired level of sedation, and morphine infusions of 2 to 30 mg/hour when they became agitated with a sedation agitation score (SAS) of 5 or higher. Group B, which received intermittent sedation, received morphine when they became agitated Results : When compared to patients receiving continuous sedation, those receiving intermittent sedation showed considerably greater SAS (P 0.001). Within 3 days of the follow-up, NAS was substantially different and lower when dealing with patients on intermittent sedation as opposed to those on continuous sedation (P values 0.001). When compared to patients receiving continuous sedation (median duration: 105 hr), those receiving intermittent sedation (median time: 47 hr, HR (95 percent CI): 4.686 (2.799: 7.847)), were on MV for a considerably shorter period of time with a greater HR of being extubated (P 0.001). While tracheostomy was not a predictor, the APACHE II score, being reintubated, and the incidence of delirium all significantly predicted the length of MV (coefficient: 2.361, 95 percent CI: 1.175 to 3.548, P0.001, coefficient: 28.411, 95 percent CI: 10.134 to 46.688, P=0.003, and coefficient: 21.222, 95 percent CI: 10.348 to 32.097, P0.001). Conclusions :Patients who had intermittent sedation experienced considerably lower rates of reintubation, NAS, brief MV stays, and longer hospital stays than those under continuous sedation, but significantly greater SAS.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.21608/bjas.2023.216978.1191
Emad El-Deen Esmat, Mohamed Ebrahim Al-Ashhab, Michael Maher Younan
Background: Medial malleolar fractures are common ankle injuries that can be managed using different surgical techniques. This research purposed to evaluate the short-term effects of percutaneous cancellous screw fixation against open reduction and internal fixation in the treatment of minimally displaced medial malleolar fractures. Methods: This study included a random sample of 20 patients who have minimally displaced medial malleolar fracture, fulfilled the inclusion criteria and completed 6 months follow up period at the Orthopedic Department of Benha University Hospitals and Mahalla General Hospital. Patients were split into 2 equal groups: Group I (Percutaneous group): included 10 patients who were treated with Closed Percutaneous cancellous screw Fixation. Group II (open group): comprised of 10 patients treated with open reduction and internal fixation. Results: A substantially critical change was present between both groups according to Operative Time which was 36.33 ± 5.16 min. in Percutaneous group and 54.00 ± 12.28 min. According to Operative outcomes in both groups, Follow-up time was about 6 months in both groups with no critical change between both groups. Union time was 9.7 ± 1.54 week in Percutaneous group and 9.1 ± 3.83 in Open group with no substantial change between both groups. Complete union was happened in 7 (70%) patients in Percutaneous group and 8 (80%) patients in Open group while delayed union has happened in 3 patients from percutaneous group and 2 patients from open group with no substantial change between both groups. Conclusions: The percutaneous technique for fixation of closed fractures of the medial malleolus is adequate and provided satisfactory final outcome but the open reduction and internal fixation allows removal of the trapped periosteal flap, direct inspection of the joint and the fracture so, it is better to use open reduction technique in all cases but in cases with bad soft tissue condition percutaneous technique could be used with acceptable results.
{"title":"Comparative study between Percutaneous screw Fixation and Open reduction and internal fixation in minimally displaced Medial Malleolar Fractures","authors":"Emad El-Deen Esmat, Mohamed Ebrahim Al-Ashhab, Michael Maher Younan","doi":"10.21608/bjas.2023.216978.1191","DOIUrl":"https://doi.org/10.21608/bjas.2023.216978.1191","url":null,"abstract":"Background: Medial malleolar fractures are common ankle injuries that can be managed using different surgical techniques. This research purposed to evaluate the short-term effects of percutaneous cancellous screw fixation against open reduction and internal fixation in the treatment of minimally displaced medial malleolar fractures. Methods: This study included a random sample of 20 patients who have minimally displaced medial malleolar fracture, fulfilled the inclusion criteria and completed 6 months follow up period at the Orthopedic Department of Benha University Hospitals and Mahalla General Hospital. Patients were split into 2 equal groups: Group I (Percutaneous group): included 10 patients who were treated with Closed Percutaneous cancellous screw Fixation. Group II (open group): comprised of 10 patients treated with open reduction and internal fixation. Results: A substantially critical change was present between both groups according to Operative Time which was 36.33 ± 5.16 min. in Percutaneous group and 54.00 ± 12.28 min. According to Operative outcomes in both groups, Follow-up time was about 6 months in both groups with no critical change between both groups. Union time was 9.7 ± 1.54 week in Percutaneous group and 9.1 ± 3.83 in Open group with no substantial change between both groups. Complete union was happened in 7 (70%) patients in Percutaneous group and 8 (80%) patients in Open group while delayed union has happened in 3 patients from percutaneous group and 2 patients from open group with no substantial change between both groups. Conclusions: The percutaneous technique for fixation of closed fractures of the medial malleolus is adequate and provided satisfactory final outcome but the open reduction and internal fixation allows removal of the trapped periosteal flap, direct inspection of the joint and the fracture so, it is better to use open reduction technique in all cases but in cases with bad soft tissue condition percutaneous technique could be used with acceptable results.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.21608/bjas.2023.218636.1196
Seham Al Berry, T. Assar, Ahmed Suliman, Mona Gohary
Background: Cervix cancer is a main cause of illness and death globally among women. It is the second most prevalent cancer and the leading cause of cancer-related death in women. To combat the condition, it is necessary to create a screening test with high specificity and sensitivity. Aim of the Work: to compare Visual Inspection with Acetic Acid, Visual Inspection with Lugol Iodine and colposcope Accuracy in Cervical Neoplasia Screening. Patients and Methods: This study is a Cross-sectional study this study was conducted in Obstetrics and Gynecology department at Benha University hospitals. The study period was carried out from February 2022 to January 2023. Results: In the current study, the mean age was 38.93±7.2 years and the most common age category was 40-50 years in 25 (38.5%) patients. In the present study, most of the studied cases 58 (89.2%) were House wife, only 4(6.2%) cases were nurse and 3 (4.6%) were Teacher. As regard to contraception, the most common Contraception used was IUCD in 34 (52.3%), then 8 (12.3%) cases used Cocs, 4(6.2%) cases used Pops and also tubal ligation, 3 (4.6%) cases used DMPA. As regard to symptoms, there were 37 (56.9%) suffer from bleeding, 47 (72.3%) cases had positive Discharge, 43 (66.2%) cases had pain. In the present study, there were 19(29.2%) cases had abnormal VIA and 46 (70.8%) cases were normal, there were 19(29.2%) cases had abnormal VILI and 46 (70.8%) cases were normal and there were 34(52.3%) cases had abnormal Colposcope and 31 (47.7%) cases were normal. By biopsy there were 32(49.2%) cases had abnormal Biopsy and 33 (50.8%) cases were normal Conclusion: The saying “preventable but not prevented" still applies to cervical cancer because there are currently no screening methods that are 100% sensitive and have good specificity . As a result, in the current study, an effort has been made to assess the colposcopy, VILI and VIA both separately and compined.
{"title":"Comparison of the Accuracy of Visual Inspection with Acetic Acid, Visual Inspection with Lugol Iodine and coloscope in Screening for Cervical Neoplasia","authors":"Seham Al Berry, T. Assar, Ahmed Suliman, Mona Gohary","doi":"10.21608/bjas.2023.218636.1196","DOIUrl":"https://doi.org/10.21608/bjas.2023.218636.1196","url":null,"abstract":"Background: Cervix cancer is a main cause of illness and death globally among women. It is the second most prevalent cancer and the leading cause of cancer-related death in women. To combat the condition, it is necessary to create a screening test with high specificity and sensitivity. Aim of the Work: to compare Visual Inspection with Acetic Acid, Visual Inspection with Lugol Iodine and colposcope Accuracy in Cervical Neoplasia Screening. Patients and Methods: This study is a Cross-sectional study this study was conducted in Obstetrics and Gynecology department at Benha University hospitals. The study period was carried out from February 2022 to January 2023. Results: In the current study, the mean age was 38.93±7.2 years and the most common age category was 40-50 years in 25 (38.5%) patients. In the present study, most of the studied cases 58 (89.2%) were House wife, only 4(6.2%) cases were nurse and 3 (4.6%) were Teacher. As regard to contraception, the most common Contraception used was IUCD in 34 (52.3%), then 8 (12.3%) cases used Cocs, 4(6.2%) cases used Pops and also tubal ligation, 3 (4.6%) cases used DMPA. As regard to symptoms, there were 37 (56.9%) suffer from bleeding, 47 (72.3%) cases had positive Discharge, 43 (66.2%) cases had pain. In the present study, there were 19(29.2%) cases had abnormal VIA and 46 (70.8%) cases were normal, there were 19(29.2%) cases had abnormal VILI and 46 (70.8%) cases were normal and there were 34(52.3%) cases had abnormal Colposcope and 31 (47.7%) cases were normal. By biopsy there were 32(49.2%) cases had abnormal Biopsy and 33 (50.8%) cases were normal Conclusion: The saying “preventable but not prevented\" still applies to cervical cancer because there are currently no screening methods that are 100% sensitive and have good specificity . As a result, in the current study, an effort has been made to assess the colposcopy, VILI and VIA both separately and compined.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"308 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139355108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.21608/bjas.2023.222175.1203
Samir Zahed, Hossam El Begawy, E. Bayomy, Sherif Eltregy, Ahmed Atallah
Background: Recurrent patellar instability is a difficult condition that frequently necessitates surgical treatment for effective management. Reconstruction of the medial patellofemoral ligament (MPFL) has become the standard surgical approach for restoring patellofemoral stability and enhancing functional results. Objective: The purpose of this research is to assess the early outcomes of MPFL reconstruction using hamstring autograft using the dual patella docking technique for the treatment of recurrent patellar instability. Conclusions: In the surgical treatment of recurrent patellar instability, MPFL reconstruction with hamstring autograft via the dual patella docking technique shows promise. The use of hamstring autograft provides sufficient strength and anatomical resemblance to the native MPFL while limiting morbidity at the donor location. The twin patella docking approach offers benefits in terms of graft attachment and tensioning, which contribute to superior outcomes.
{"title":"Reconstruction of Medial Patellofemoral Ligament in the Treatment of Recurrent Patellar Instability using Hamstring Autograft by Dual Patella Docking Technique: A Comparative Review","authors":"Samir Zahed, Hossam El Begawy, E. Bayomy, Sherif Eltregy, Ahmed Atallah","doi":"10.21608/bjas.2023.222175.1203","DOIUrl":"https://doi.org/10.21608/bjas.2023.222175.1203","url":null,"abstract":"Background: Recurrent patellar instability is a difficult condition that frequently necessitates surgical treatment for effective management. Reconstruction of the medial patellofemoral ligament (MPFL) has become the standard surgical approach for restoring patellofemoral stability and enhancing functional results. Objective: The purpose of this research is to assess the early outcomes of MPFL reconstruction using hamstring autograft using the dual patella docking technique for the treatment of recurrent patellar instability. Conclusions: In the surgical treatment of recurrent patellar instability, MPFL reconstruction with hamstring autograft via the dual patella docking technique shows promise. The use of hamstring autograft provides sufficient strength and anatomical resemblance to the native MPFL while limiting morbidity at the donor location. The twin patella docking approach offers benefits in terms of graft attachment and tensioning, which contribute to superior outcomes.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.21608/bjas.2023.223680.1207
Mohamed Salah Addin Shawky, Elsayed Mahmoud Bayomy, Mohammed Ahmed Abdallah Mohamed Gharib
Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure for individuals with ACL injuries. The choice of graft material is crucial for the success of the surgery, with minimally invasive quadriceps tendon autografts and hamstring tendon autografts being the most frequently used options. Objective: This comparative review aims to analyze and compare the outcomes of arthroscopic ACL reconstruction using minimally invasive quadriceps tendon autografts and hamstring tendon autografts. The objective is to provide valuable insights into the advantages, limitations, and clinical efficacy of each graft option. Conclusions: Both minimally invasive quadriceps tendon autografts and hamstring tendon autografts have demonstrated positive outcomes in arthroscopic ACL reconstruction. Each graft option has its own advantages and limitations, such as graft strength, harvest site morbidity, postoperative pain, and recovery time. Surgeons and patients can use this information to make informed decisions regarding graft selection in ACL reconstruction.
{"title":"Minimally Invasive Quadriceps vs Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction: A Comparative Review","authors":"Mohamed Salah Addin Shawky, Elsayed Mahmoud Bayomy, Mohammed Ahmed Abdallah Mohamed Gharib","doi":"10.21608/bjas.2023.223680.1207","DOIUrl":"https://doi.org/10.21608/bjas.2023.223680.1207","url":null,"abstract":"Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure for individuals with ACL injuries. The choice of graft material is crucial for the success of the surgery, with minimally invasive quadriceps tendon autografts and hamstring tendon autografts being the most frequently used options. Objective: This comparative review aims to analyze and compare the outcomes of arthroscopic ACL reconstruction using minimally invasive quadriceps tendon autografts and hamstring tendon autografts. The objective is to provide valuable insights into the advantages, limitations, and clinical efficacy of each graft option. Conclusions: Both minimally invasive quadriceps tendon autografts and hamstring tendon autografts have demonstrated positive outcomes in arthroscopic ACL reconstruction. Each graft option has its own advantages and limitations, such as graft strength, harvest site morbidity, postoperative pain, and recovery time. Surgeons and patients can use this information to make informed decisions regarding graft selection in ACL reconstruction.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139356094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.21608/bjas.2023.215490.1182
Hanan Yousef
{"title":"Fabrication, Structural and Photocatalytic Studies of Titanium Dioxide urchin-like Nanoparticles for the Removal of Organic Dye from Aqueous Media","authors":"Hanan Yousef","doi":"10.21608/bjas.2023.215490.1182","DOIUrl":"https://doi.org/10.21608/bjas.2023.215490.1182","url":null,"abstract":"","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90425831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21608/bjas.2023.224465.1211
Mohamed Kamal Elkhouly, Hisham Khalid Rasheed, Eman Saeed El-Keshk, AL-Shimaa Mohamed sabry
Background: Rheumatic heart disease (RHD) remains a significant health burden in many parts of the world, particularly in developing countries. Rheumatic mitral stenosis (MS) is one of the most common manifestations of RHD, characterized by the narrowing of the mitral valve orifice due to chronic inflammation and fibrosis. The aim of this study was to assess left ventricular systolic function in patients with rheumatic mitral stenosis by speckle tracking echocardiography. Methods: This was a single center, cross sectional, comparative study that was conducted at the cardiology department of Benha University Hospital from July 2019 to July 2021 on with isolated rheumatic mitral stenosis and preserved LV function. All patients were subjected to full history taking including age, gender and cardiovascular risk factors including smoking, hypertension, and diabetes. NYHA functional classification and clinical examination: including heart rate, systolic and diastolic blood pressure, chest and heart auscultation. D-Laboratory investigations, ECG and Transthoracic Echocardiography (TTE). Results: There was no statistically significant difference observed among the studied group regarding the age (p=0.368). The gender distribution showed varying proportions of males (14%, 8%, and 24%) and females (86%, 92%, and 76%) in the Moderate MS, Severe MS, and Control groups, respectively, but no statistically significant difference in gender distribution was found among the groups (p=0.317). Conclusions: Speckle tracking echocardiography is a reliable and effective tool for evaluating left ventricular systolic function in patients with rheumatic mitral stenosis. This non-invasive technique allows for a comprehensive assessment of myocardial mechanics, providing valuable information beyond traditional echocardiographic parameters.
{"title":"Evaluation of Left Ventricular Function in Patient with Rheumatic Mitral Stenosis by Using Speckle Tracking Echocardiography","authors":"Mohamed Kamal Elkhouly, Hisham Khalid Rasheed, Eman Saeed El-Keshk, AL-Shimaa Mohamed sabry","doi":"10.21608/bjas.2023.224465.1211","DOIUrl":"https://doi.org/10.21608/bjas.2023.224465.1211","url":null,"abstract":"Background: Rheumatic heart disease (RHD) remains a significant health burden in many parts of the world, particularly in developing countries. Rheumatic mitral stenosis (MS) is one of the most common manifestations of RHD, characterized by the narrowing of the mitral valve orifice due to chronic inflammation and fibrosis. The aim of this study was to assess left ventricular systolic function in patients with rheumatic mitral stenosis by speckle tracking echocardiography. Methods: This was a single center, cross sectional, comparative study that was conducted at the cardiology department of Benha University Hospital from July 2019 to July 2021 on with isolated rheumatic mitral stenosis and preserved LV function. All patients were subjected to full history taking including age, gender and cardiovascular risk factors including smoking, hypertension, and diabetes. NYHA functional classification and clinical examination: including heart rate, systolic and diastolic blood pressure, chest and heart auscultation. D-Laboratory investigations, ECG and Transthoracic Echocardiography (TTE). Results: There was no statistically significant difference observed among the studied group regarding the age (p=0.368). The gender distribution showed varying proportions of males (14%, 8%, and 24%) and females (86%, 92%, and 76%) in the Moderate MS, Severe MS, and Control groups, respectively, but no statistically significant difference in gender distribution was found among the groups (p=0.317). Conclusions: Speckle tracking echocardiography is a reliable and effective tool for evaluating left ventricular systolic function in patients with rheumatic mitral stenosis. This non-invasive technique allows for a comprehensive assessment of myocardial mechanics, providing valuable information beyond traditional echocardiographic parameters.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Infertility is a prevalent concern affecting numerous couples worldwide, often caused by anovulation or irregular ovulation. Induced ovulation using pharmacological agents, such as letrozole and clomiphene citrate, is a commonly employed approach to enhance fertility. However, the impact of these medications on endometrial receptivity, a critical factor for successful implantation and pregnancy, remains an area of ongoing research. The primary goal of this research was to compare endometrial receptivity during induced ovulation by letrazole or clomiphene citrate. Methods: This study was prospective comparative research where 120 PCO and infertility more than 1-year women were included and divided into 2 groups: Group A (Clomid induction group) (odd numbers); Clomid was administered in 100 mg/day for 5 days dose starting from day 3 to day 7. In this group, 130 women were followed and only 60 women were included, and 70 women were excluded because either data loss or failed ovulation. Group B (Letrozole induction group) (even numbers); Letrozole was given in the dose of 5 mg/day for 5 days starting from day 3 to day 7. In this group, 90 women were followed, and 60 women were included, and 30 women were excluded because either data loss or failed ovulation. Results: The results demonstrate significant differences in endometrial thickness among the two groups. On the 11th day of the cycle, Group B exhibited a significantly higher endometrial thickness (9.82 ± 0.21 mm) compared to Group A (7.00 ± 0.21 mm) (T = -73.53, p < 0.0001). Similarly, at the stage of mature follicle (follicle > 18mm), Group B showed a significantly greater endometrial thickness (10.22 ± 0.20 mm) compared to Group A (7.49 ± 0.20 mm) (T = -73.49, p < 0.0001). Furthermore, even 7 days after ovulation, Group B maintained a significantly thicker endometrium (10.65 ± 0.22 mm) compared to Group A (7.81 ± 0.20 mm) (T = -74.33, p < 0.0001). Conclusions: Letrozole induces a greater rise in endometrial thickness and conception rate than Clomiphene citrate in infertile PCOS women. Letrozole may enhance fertility by increasing endometrial receptivity relative to CC.
{"title":"Ultrasonographic comparative study between letrazole and clomiphene citrate on endometrial receptivity during induced ovulation","authors":"Hazem Mohamed, Khaled Slama, Samar Ali, Sobhy Mahmoud","doi":"10.21608/bjas.2023.211905.1172","DOIUrl":"https://doi.org/10.21608/bjas.2023.211905.1172","url":null,"abstract":"Background: Infertility is a prevalent concern affecting numerous couples worldwide, often caused by anovulation or irregular ovulation. Induced ovulation using pharmacological agents, such as letrozole and clomiphene citrate, is a commonly employed approach to enhance fertility. However, the impact of these medications on endometrial receptivity, a critical factor for successful implantation and pregnancy, remains an area of ongoing research. The primary goal of this research was to compare endometrial receptivity during induced ovulation by letrazole or clomiphene citrate. Methods: This study was prospective comparative research where 120 PCO and infertility more than 1-year women were included and divided into 2 groups: Group A (Clomid induction group) (odd numbers); Clomid was administered in 100 mg/day for 5 days dose starting from day 3 to day 7. In this group, 130 women were followed and only 60 women were included, and 70 women were excluded because either data loss or failed ovulation. Group B (Letrozole induction group) (even numbers); Letrozole was given in the dose of 5 mg/day for 5 days starting from day 3 to day 7. In this group, 90 women were followed, and 60 women were included, and 30 women were excluded because either data loss or failed ovulation. Results: The results demonstrate significant differences in endometrial thickness among the two groups. On the 11th day of the cycle, Group B exhibited a significantly higher endometrial thickness (9.82 ± 0.21 mm) compared to Group A (7.00 ± 0.21 mm) (T = -73.53, p < 0.0001). Similarly, at the stage of mature follicle (follicle > 18mm), Group B showed a significantly greater endometrial thickness (10.22 ± 0.20 mm) compared to Group A (7.49 ± 0.20 mm) (T = -73.49, p < 0.0001). Furthermore, even 7 days after ovulation, Group B maintained a significantly thicker endometrium (10.65 ± 0.22 mm) compared to Group A (7.81 ± 0.20 mm) (T = -74.33, p < 0.0001). Conclusions: Letrozole induces a greater rise in endometrial thickness and conception rate than Clomiphene citrate in infertile PCOS women. Letrozole may enhance fertility by increasing endometrial receptivity relative to CC.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135857580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21608/bjas.2023.221160.1200
Basma Mohamed, Mohamed Mohamed, Amr Sharaf Eldeen, Basma Sakr
Background: Postpartum hemorrhage (PPH) is a significant cause of maternal morbidity and mortality. This study aimed to evaluate and compare between carbetocin & oxytocin for post-partum haemorrhage prophylaxis among high-risk women giving birth through Vaginal Delivery and Caesarean Section. Methods: total of 200 singleton pregnant women with at least one risk factor for atonic PPH were included in the study. They were randomly assigned to two groups: Group A received carbetocin (n=100) and Group B received oxytocin (n=100). Clinical assessments, including blood pressure monitoring, blood loss measurement, and changes in hemoglobin concentrations, were conducted. Maternal demographics, risk factors, and outcomes such as PPH, need for additional uterotonics, and blood transfusion were analyzed. Results: Postpartum, both groups experienced increased pulse and blood pressure, with the oxytocin group showing considerably higher systolic and diastolic blood pressure (P-value < 0.001). Hemoglobin and hematocrit levels considerably decreased postpartum, with the oxytocin group exhibiting greater decreases (P-value < 0.001). Estimated blood loss, PPH incidence, and the need for additional uterotonics and blood transfusion were considerably lower in the carbetocin group (P-value < 0.001). Uterine tone was considerably better in the carbetocin group compared to the oxytocin group (P-value < 0.001). Conclusions: Carbetocin demonstrated superior efficacy in reducing blood loss and preventing PPH compared to oxytocin among high-risk women undergoing vaginal delivery and cesarean section.
{"title":"Effect of Carbetocin on Blood Loss after Cesarean Section or Vaginal Delivery","authors":"Basma Mohamed, Mohamed Mohamed, Amr Sharaf Eldeen, Basma Sakr","doi":"10.21608/bjas.2023.221160.1200","DOIUrl":"https://doi.org/10.21608/bjas.2023.221160.1200","url":null,"abstract":"Background: Postpartum hemorrhage (PPH) is a significant cause of maternal morbidity and mortality. This study aimed to evaluate and compare between carbetocin & oxytocin for post-partum haemorrhage prophylaxis among high-risk women giving birth through Vaginal Delivery and Caesarean Section. Methods: total of 200 singleton pregnant women with at least one risk factor for atonic PPH were included in the study. They were randomly assigned to two groups: Group A received carbetocin (n=100) and Group B received oxytocin (n=100). Clinical assessments, including blood pressure monitoring, blood loss measurement, and changes in hemoglobin concentrations, were conducted. Maternal demographics, risk factors, and outcomes such as PPH, need for additional uterotonics, and blood transfusion were analyzed. Results: Postpartum, both groups experienced increased pulse and blood pressure, with the oxytocin group showing considerably higher systolic and diastolic blood pressure (P-value < 0.001). Hemoglobin and hematocrit levels considerably decreased postpartum, with the oxytocin group exhibiting greater decreases (P-value < 0.001). Estimated blood loss, PPH incidence, and the need for additional uterotonics and blood transfusion were considerably lower in the carbetocin group (P-value < 0.001). Uterine tone was considerably better in the carbetocin group compared to the oxytocin group (P-value < 0.001). Conclusions: Carbetocin demonstrated superior efficacy in reducing blood loss and preventing PPH compared to oxytocin among high-risk women undergoing vaginal delivery and cesarean section.","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136301129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21608/bjas.2023.222149.1202
Karim Reda Karim, Fatma Mohamed El Esswey, Amany Ibrahim Mustafa, Maha Othman
Background: Vitiligo is a depigmenting skin condition characterized by specific melanocyte depletion, resulting in the attenuation of melanin within the affected skin regions. Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of vitiligo. This study aimed to investigate the gene expression levels of Uncoupling Protein 2 (UCP2) and Dynamin-related Protein 1 (Drp1) in vitiligo patients and their potential association with disease severity and activity. Methods: This case-control study was conducted, including 40 vitiligo patients and 40 age and sex-matched healthy controls. Gene expression levels of UCP2 and Drp1 were measured in plasma samples using an enzyme-linked immunosorbent assay (ELISA). Results: The study included 40 patients with vitiligo. Their mean age was 28.9 years. They were 77.5% males and 22.5% females. In addition to 40 healthy control subjects od matched age and gender (p≥ 0.05). The study revealed significant downregulation of UCP2 gene expression and upregulation of Drp1 gene expression in vitiligo patients compared to healthy controls. Conclusions: The findings suggest that dysregulation of UCP2 and Drp1 gene expression may play a role in the pathogenesis of vitiligo
{"title":"Uncoupling Protein 2 and Dynamin-related Protein 1mRNA Expression as Genetic Markers for Vitiligo","authors":"Karim Reda Karim, Fatma Mohamed El Esswey, Amany Ibrahim Mustafa, Maha Othman","doi":"10.21608/bjas.2023.222149.1202","DOIUrl":"https://doi.org/10.21608/bjas.2023.222149.1202","url":null,"abstract":"Background: Vitiligo is a depigmenting skin condition characterized by specific melanocyte depletion, resulting in the attenuation of melanin within the affected skin regions. Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of vitiligo. This study aimed to investigate the gene expression levels of Uncoupling Protein 2 (UCP2) and Dynamin-related Protein 1 (Drp1) in vitiligo patients and their potential association with disease severity and activity. Methods: This case-control study was conducted, including 40 vitiligo patients and 40 age and sex-matched healthy controls. Gene expression levels of UCP2 and Drp1 were measured in plasma samples using an enzyme-linked immunosorbent assay (ELISA). Results: The study included 40 patients with vitiligo. Their mean age was 28.9 years. They were 77.5% males and 22.5% females. In addition to 40 healthy control subjects od matched age and gender (p≥ 0.05). The study revealed significant downregulation of UCP2 gene expression and upregulation of Drp1 gene expression in vitiligo patients compared to healthy controls. Conclusions: The findings suggest that dysregulation of UCP2 and Drp1 gene expression may play a role in the pathogenesis of vitiligo","PeriodicalId":8745,"journal":{"name":"Benha Journal of Applied Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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