Behavioural Brain Research最新文献_第9页

Electroacupuncture ameliorates mitochondrial dysfunction and alleviates traumatic brain injury via the PANX1/ATP/Ca2+ pathway 电针通过PANX1/ATP/Ca2+通路改善线粒体功能障碍，减轻创伤性脑损伤。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-11-04 DOI: 10.1016/j.bbr.2025.115918

Quanxiu Liu , Fang Tan , Jinpeng Wen , Chi Ma , Zitong Wang , Xu Fan

Traumatic brain injury (TBI) involves complex pathophysiological processes. This study investigates the therapeutic effects of electroacupuncture (EA) on mitochondrial dysfunction and TBI in rats through the PANX1/ATP/Ca²⁺ pathway, thereby providing effective intervention targets for TBI. A TBI rat model was established using the cortical controlled impact method, followed by behavioral tests (modified neurological severity score, rotarod test, grip strength test, and balance beam test) to assess the neurological function. Brain edema, neuronal apoptosis, and oxidative stress were evaluated using histological staining, Enzyme-linked immunosorbent assay, and Western blotting. The results showed that EA treatment significantly improved the motor coordination, reduced the brain water content, and preserved neuronal integrity. Moreover, EA reduced levels of oxidative stress, inflammation, and apoptosis markers. EA also inhibited the PANX1/ATP/Ca²⁺ pathway, Ca²⁺ levels, caspase-3 activation, and mitochondrial Cyt C, while enhancing ATP, NAD+ /NADPH levels, and mitochondrial respiratory chain complex activity. These findings suggest that EA mitigates mitochondrial dysfunction and oxidative stress, thereby improving neurological outcomes and reducing brain edema in TBI rats. Inhibition of PANX1 expression further confirmed its role in modulating TBI-related pathology via the PANX1/ATP/Ca²⁺ axis.

创伤性脑损伤（TBI）是一个复杂的病理生理过程。本研究探讨电针（EA）通过PANX1/ATP/Ca2+通路对大鼠线粒体功能障碍和TBI的治疗作用，从而为TBI提供有效的干预靶点。采用皮质控制冲击法建立脑损伤大鼠模型，并进行行为学测试（改良神经严重程度评分、旋转杆测试、握力测试、平衡木测试）评估神经功能。采用组织学染色、酶联免疫吸附试验和Western blotting评估脑水肿、神经元凋亡和氧化应激。结果表明，EA治疗显著改善了大鼠的运动协调性，降低了脑含水量，并保持了神经元的完整性。此外，EA还能降低氧化应激、炎症和细胞凋亡标志物的水平。EA还抑制PANX1/ATP/Ca2+通路、Ca2+水平、caspase-3激活和线粒体Cyt C，同时增强ATP、NAD+/NADPH水平和线粒体呼吸链复合物活性。这些发现表明，EA减轻了线粒体功能障碍和氧化应激，从而改善了脑损伤大鼠的神经预后，减少了脑水肿。PANX1表达的抑制进一步证实了其通过PANX1/ATP/Ca2+轴调节tbi相关病理的作用。

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引用次数: 0

Salicin ameliorates Alzheimer’s-like pathology by modulation of NTSP/CSP/GLM pathways: An integrated in silico and in vivo approach 水杨苷通过调节NTSP/CSP/GLM通路改善阿尔茨海默病样病理：一种集成在硅和体内的方法

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-11-03 DOI: 10.1016/j.bbr.2025.115907

Padmaja Kore , Utkarsha Patil , Shrinath Bodkhe , Deepti Bandawane , Aishwarya Pandit , Anuradha More

Alzheimer’s disease (AD) is marked by modifiable and non-modifiable risk factors. Despite existing treatments, effective therapies to halt or reverse AD progression remain limited, highlighting the urgent need for new multitarget strategies. Phytotherapy as an anti-AD approach has emerged as an increasingly promising strategy in combating neurodegeneration, triggered by suppression of neuronal oxidation and inflammation. Salicin is a natural substance found in willow bark with anti-inflammatory and antioxidant effects. The present study investigates the protective effects of Salicin on neurodegeneration triggered by Scopolamine (Scop). Network pharmacology identified target pathways and genes involved in AD pathogenesis and suggested Salicin as a potential therapeutic agent. Molecular docking elucidated interactions within these target pathways. Scop (1 mg/kg, i.p.) induced memory dysfunction, and Salicin was administered at 12.5, 25, and 50 mg/kg (i.p.). Behavioral parameters were assessed for recognition and spatial memory using Novel Object Recognition (NOR) and Radial Arm Maze (RAM), respectively. AChE, BDNF, and PSEN-1 levels were studied as per in silico predictions, and microscopic changes in hippocampus and cortex were observed via histopathology. Top three pathways of Salicin were identified. The results of in silico and in vivo analyses demonstrate that the protective effects of Salicin are mediated through the Neurotrophin Signaling Pathway (NTSP), Cholinergic Synapse Pathway (CSP), and Glycerolipid Metabolism Pathway (GLM), which are critically implicated in AD progression. Relevant behavioral and histopathological improvements were observed. This study provides preliminary evidence supporting the potential of Salicin as a therapeutic candidate for AD, offering valuable direction for future research.

阿尔茨海默病（AD）的特点是可改变和不可改变的危险因素。尽管已有治疗方法，但阻止或逆转AD进展的有效疗法仍然有限，因此迫切需要新的多靶点策略。植物疗法作为一种抗阿尔茨海默病的方法已经成为一种越来越有前途的治疗神经退行性疾病的策略，这种疾病是由抑制神经元氧化和炎症引起的。水杨苷是柳树皮中发现的一种天然物质，具有抗炎和抗氧化作用。本研究探讨水杨苷对东莨菪碱引起的神经退行性变的保护作用。网络药理学鉴定了AD发病机制的靶通路和基因，认为水杨苷是潜在的治疗药物。分子对接阐明了这些靶通路内的相互作用。scopp （1mg/kg, i.p.）诱导记忆功能障碍，水杨苷12.5、25和50mg/kg （i.p.）给药。采用新目标识别（NOR）和径向臂迷宫（RAM）分别评估识别和空间记忆的行为参数。根据计算机预测研究AChE、BDNF和PSEN-1水平，并通过组织病理学观察海马和皮层的微观变化。确定了水杨苷的前3条途径。体外和体内分析结果表明，水杨苷的保护作用是通过神经营养因子信号通路（NTSP）、胆碱能突触通路（CSP）和甘油脂代谢途径（GLM）介导的，这些途径与AD的进展有重要关系。观察到相关的行为和组织病理学改善。本研究为水杨苷作为阿尔茨海默病候选药物的潜力提供了初步证据，为今后的研究提供了有价值的方向。

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引用次数: 0

Female mice in established social groups use different ultrasonic vocalizations during peaceful and aggressive interactions 在已建立的社会群体中，雌性老鼠在和平和攻击性的互动中使用不同的超声波发声。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-11-01 DOI: 10.1016/j.bbr.2025.115904

Anna V. Klenova , Benjamin Lang , Anne Jaap , Christa Thöne-Reineke , Lars Lewejohann , Paul Mieske

The ultrasonic vocalizations (USVs) of house mice (Mus musculus) have a surprisingly complex structure and have been actively studied as a model for applied questions in biomedical science. Despite this, the functional significance of different USV types and their use during natural social behaviour in diverse groups remains unclear. In this pilot long-term study, we examined the ultrasound activity of female mice housed in stable groups within an enriched environment, focusing on how behavioural context influences USV time-frequency characteristics, call type occurrence, and nonlinear phenomena. Our findings show that USVs are mainly produced in bouts, and bouts containing ten or more variable calls always accompanying direct social interactions. USV variables and types varied markedly depending on the interaction context. During aggressive encounters, USVs and entire bouts became longer, vocalization time and frequency modulation increased, while peak and minimum fundamental frequencies decreased. Additionally, aggressive context was characterized by a higher prevalence of multi-component and complex-low USVs (with peak frequency < 50 kHz), and increased nonlinear phenomena. These results suggest that USV features closely reflect emotional arousal (intensity) and probably also valence (positive/negative) in female mice during social hierarchy formation and maintenance. Notably, the relationship between arousal and nonlinear vocal phenomena in mice USVs follows patterns observed in audible vocalizations of other mammals (increase with arousal). In the future, complex-low USVs could potentially serve as non-invasive indicators of negative emotional expression in groups of female mice. This opens new possibilities for acoustic home-cage monitoring aimed at welfare assessment and other applied uses.

家鼠（Mus musculus）的超声发声（USVs）具有令人惊讶的复杂结构，并作为生物医学应用问题的模型被积极研究。尽管如此，不同USV类型的功能意义及其在不同群体自然社会行为中的使用仍不清楚。在这项初步的长期研究中，我们研究了在丰富的环境中饲养的稳定组的雌性小鼠的超声活动，重点关注行为背景如何影响USV时频特性，呼叫类型发生和非线性现象。我们的研究结果表明，usv主要是在回合中产生的，回合包含十个或更多的变量呼叫，总是伴随着直接的社会互动。USV变量和类型因交互环境的不同而有显著差异。在激烈的战斗中，usv和整个回合变得更长，发声时间和频率调制增加，而峰值和最低基频降低。此外，侵略性环境的特点是多分量和复杂低usv（峰值频率< 50kHz）的发生率更高，非线性现象增加。这些结果表明，USV特征密切反映了雌性小鼠在社会等级形成和维持过程中的情绪唤醒（强度），可能也反映了效价（正/负）。值得注意的是，在小鼠usv中，唤醒和非线性发声现象之间的关系遵循了在其他哺乳动物的可听发声中观察到的模式（随着唤醒而增加）。在未来，复合物-低usv有可能作为雌性小鼠群体负性情绪表达的非侵入性指标。这为旨在进行福利评估和其他应用的家庭笼声监测开辟了新的可能性。

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引用次数: 0

The serotonergic 5-HT7 receptor: A therapeutic target for mitigating acute stress-induced cognitive, neuroinflammatory, and oxidative damage in the hippocampus 5-羟色胺能5-HT7受体：减轻海马急性应激诱导的认知、神经炎症和氧化损伤的治疗靶点

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-31 DOI: 10.1016/j.bbr.2025.115901

Nasrin Abdolmaleki , Siamak Shahidi , Ali Haeri Rohani , Parisa Habibi

This study investigates the role of 5-HT7 receptors in mediating repeated acute stress-induced impairments on memory, hippocampal neuronal health, neuroinflammation, and oxidative stress in mice. By elucidating these mechanisms, we aim to identify novel therapeutic targets to mitigate cognitive deficits resulting from acute stress. Mice were randomly assigned to four groups: control, stress, 5-HT7 receptor agonist (AS19, 5 mg/kg, i.p.) + stress, and 5-HT7 receptor antagonist (SB-269970, 2.5 mg/kg, i.p.) + stress. Cognitive and avoidance memory were assessed using the novel object recognition (NOR) and passive avoidance (PA) tests, respectively. Hippocampus tissue was analyzed for BDNF levels via ELISA, neuronal density through hematoxylin staining, and TNFα inflammatory marker via immunofluorescence. Additionally, oxidative stress markers including total oxidant status (TOS), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), total thiol groups (TTG), and glutathione (GSH) were measured. Our findings demonstrate that repeated acute stress significantly impairs memory, reduces hippocampal BDNF levels and neuronal density, and increases neuroinflammation and oxidative stress. Crucially, administration of the 5-HT7 receptor agonist, AS19, effectively ameliorated these stress-induced deficits, while the antagonist, SB-269970, had no protective effect. These results highlight the 5-HT7 receptor as a promising therapeutic target for combating the detrimental effects of acute stress on brain health and cognitive function.

本研究探讨了5-HT7受体在小鼠记忆、海马神经元健康、神经炎症和氧化应激中介导急性应激性损伤的作用。通过阐明这些机制，我们旨在确定新的治疗靶点，以减轻急性应激引起的认知缺陷。小鼠随机分为4组：对照组、应激组、5-HT7受体激动剂（AS19, 5mg/kg, i.p）。+应激，5-HT7受体拮抗剂（SB-269970, 2.5mg/kg, i.p）+压力。认知记忆和回避记忆分别采用新目标识别（NOR）和被动回避（PA）测试进行评估。ELISA法检测海马组织BDNF水平，苏木精染色法检测神经元密度，免疫荧光法检测TNFα炎症标志物。此外，测定氧化应激标志物，包括总氧化状态（TOS）、丙二醛（MDA）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）、总硫醇群（TTG）和谷胱甘肽（GSH）。我们的研究结果表明，反复的急性应激显著损害记忆，降低海马BDNF水平和神经元密度，增加神经炎症和氧化应激。关键是，施用5-HT7受体激动剂AS19可以有效改善这些应激诱导的缺陷，而拮抗剂SB-269970则没有保护作用。这些结果突出了5-HT7受体作为对抗急性应激对大脑健康和认知功能的有害影响的有希望的治疗靶点。

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引用次数: 0

Corrigendum to “The mechanism of electroacupuncture treatment for post-stroke spasticity: A systematic review and meta-analysis” [Behav. Brain Res. 497 (2026) 115873] 《电针治疗脑卒中后痉挛的机制：一项系统综述和荟萃分析》的更正。中国生物医学工程学报，2015(5):357 - 357。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115897

Lei You , Mengwan Hu , Jingang Li , Jiahui Tan , Fengmin Guo , Ying Kong

引用次数: 0

Individual differences in frequency modulated 50-kHz ultrasonic vocalizations reflect but do not predict cocaine self-administration in rats 频率调制50 khz超声波发声的个体差异反映但不能预测大鼠的可卡因自我给药。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115906

Anna Skórzewska , Karolina Kuchniak , Edyta Wyszogrodzka , Ewa Taracha

Frequency-modulated (FM) 50-kHz ultrasonic vocalizations (USVs) in rats reflect a positive emotional state. The aim of this study was to evaluate whether anticipatory and cocaine-induced FM 50-kHz USVs can predict individual vulnerability to cocaine self-administration behavior. Twenty singly housed rats underwent behavioral testing (elevated plus maze, novel object recognition, and tickling-induced vocalizations) and amphetamine sensitization. The animals then participated in 22 self-administration (SA) sessions (2 days on / 1 day off), during which active nose pokes and FM 50-kHz USVs were recorded during both the anticipatory (cocaine-free) and cocaine phases. Despite pronounced individual differences in SA levels, none of the analyzed behavioral markers predicted SA acquisition. The FM 50-kHz USV response to the first dose of amphetamine showed a bimodal distribution; rats with a weak response exhibited significantly higher levels of cocaine SA. Due to substantial behavioral differences, further analyses were conducted in low-SA and high-SA groups. Anticipatory FM 50-kHz USVs did not correlate with SA intensity and were similarly high in both groups. During the cocaine phase, high-SA rats displayed significantly stronger vocal responses than low-SA rats. FM 50-kHz USVs reflect both contextual and drug-induced positive affect but are highly sensitive to housing conditions and experimental procedures. The response to the first amphetamine dose may serve as a predictive marker of vulnerability to cocaine SA. However, anticipatory FM 50-kHz USVs do not provide a reliable indicator of SA intensity. Accurate interpretation of FM 50-kHz USVs requires integration with behavioral and neurobiological markers to effectively identify addiction risk phenotypes.

调频（FM） 50 khz超声发声（usv）在大鼠反映积极的情绪状态。本研究的目的是评估预期性和可卡因诱导的FM 50-kHz usv是否可以预测个体对可卡因自我给药行为的易感性。20只单独饲养的大鼠进行了行为测试（升高+迷宫，新物体识别和挠痒诱导的发声）和安非他明致敏。然后，这些动物参加了22个自我给药（SA）阶段（2天开/ 1天休息），在此期间，在预期（无可卡因）和可卡因阶段记录活跃的鼻子戳和FM 50-kHz usv。尽管SA水平存在显著的个体差异，但所分析的行为标记都不能预测SA的获得。FM对第一剂量安非他明的50-kHz USV响应呈双峰分布；反应较弱的大鼠表现出明显较高的可卡因SA水平。由于行为学差异很大，我们对低sa组和高sa组进行了进一步的分析。预期调频50-kHz usv与SA强度无关，在两组中同样高。在可卡因阶段，高sa大鼠的声音反应明显强于低sa大鼠。FM 50-kHz usv反映了环境和药物诱导的积极影响，但对住房条件和实验程序高度敏感。对第一剂量安非他明的反应可以作为对可卡因SA易感性的预测标志。然而，预期调频50-kHz usv不能提供SA强度的可靠指标。准确解释FM 50-kHz usv需要与行为和神经生物学标记相结合，以有效识别成瘾风险表型。

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引用次数: 0

PET-measured tau deposition in emotion-related brain regions is differentially associated with depressive symptoms in individuals with versus without Alzheimer’s disease pathology pet测量的情绪相关脑区域的tau沉积与阿尔茨海默病病理与非阿尔茨海默病病理个体的抑郁症状存在差异。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115889

Erika Glaubitz, Xiuyuan Hugh Wang, Ke Xi, Farnia Feiz, Silky Pahlajani, Tom Maloney, Emily Tanzi, Hani Hojjati, Liangong Zhou, Lidia Glodzik, Gloria Chiang, Yi Li, Ray Razlighi, Mony de Leon, Tracy Butler

Depressive symptoms are common in patients diagnosed with Alzheimer’s Disease (AD) and can also precede AD as a risk factor and/or prodrome. Brain deposition of hyper-phosphorylated tau is a hallmark pathology of AD. Tau deposition in brain regions involved in emotional processing is likely to be pathophysiologically relevant to these links between AD and depression. We used 18F-MK6240 PET to measure tau in amygdala, hippocampus, and nucleus accumbens—regions implicated in depression—in 141 participants with and without AD. In addition to tau PET, participants underwent amyloid-beta (Aβ) PET, MRI, and cognitive evaluation. Depressive symptoms were assessed with the Beck Depression Inventory (BDI). Multiple regression analyzed contributions of tau and Aβ status (positive vs. negative), depression (BDI > 13), cognition (impaired vs. normal), age and sex to tau burden in the three regions. A significant interaction between tau status and depression prompted subgroup analyses of tau-positive (n = 34) and tau-negative (n = 107) participants. Among tau-positive participants, depression was associated with greater tau in the nucleus accumbens, a region critical for reward processing and motivation. This finding suggests that tau-mediated accumbens dysfunction may contribute to anhedonia, a key symptom of depression that is particularly common in AD-related depression. In tau-negative participants, greater depression was associated with less tau in the medial temporal lobe. This unexpected finding requires confirmation through further research, but could reflect impaired neurogenesis in depression without AD pathology.

抑郁症状在诊断为阿尔茨海默病（AD）的患者中很常见，也可以作为AD的危险因素和/或前驱症状。脑内过度磷酸化的tau沉积是阿尔茨海默病的标志性病理。参与情绪处理的大脑区域的Tau沉积可能与AD和抑郁症之间的这些联系有病理生理学上的相关性。我们使用18F-MK6240 PET测量141名AD患者和非AD患者杏仁核、海马和伏隔核中与抑郁有关的tau蛋白。除了tau PET外，参与者还接受了β淀粉样蛋白（Aβ） PET、MRI和认知评估。用贝克抑郁量表（BDI）评估抑郁症状。多元回归分析了三个区域tau和Aβ状态（阳性与阴性）、抑郁（BDI bbb13）、认知（受损与正常）、年龄和性别对tau负担的贡献。tau状态和抑郁之间的显著相互作用促使对tau阳性（n=34）和tau阴性（n=107）参与者进行亚组分析。在tau阳性的参与者中，抑郁与伏隔核中较大的tau有关，伏隔核是一个对奖励处理和动机至关重要的区域。这一发现表明，tau介导的伏隔核功能障碍可能导致快感缺乏症，这是抑郁症的一个关键症状，在ad相关抑郁症中尤为常见。在tau阴性的参与者中，更大的抑郁与内侧颞叶中较少的tau相关。这一意想不到的发现需要通过进一步的研究来证实，但可能反映了没有AD病理的抑郁症的神经发生受损。

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引用次数: 0

Ultrasonic calls accompanying affiliative contacts between adult groupmates in two Lasiopodomys vole species 两种Lasiopodomys田鼠成年群体间亲缘接触的超声呼叫

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115903

Ilya A. Volodin , Margarita M. Dymskaya , Antonina V. Smorkatcheva , Elena V. Volodina

Ultrasonic calls (USVs) produced by rodents during contacts with group members are poorly studied compared to USVs elicited by isolation, handling, mate exposition or dyad same-sex interactions on a neutral territory. In this study, we apply a procedure for eliciting the USVs accompanying contacts between adult voles living in permanent social groups for two Lasiopodomys vole species. The values of all variables of fundamental and peak frequencies were significantly higher in L. brandtii than in L. mandarinus, the duration of USVs was two times longer in L. brandtii than in L. mandarinus. At the same time, the USVs did not differ between species in the occurrence of different call contours, nonlinear phenomena and note compositions. The USVs emitted during affiliative contacts were acoustically nearly identical to the low-frequency USVs described previously for these two species in the situation of short-term isolation from conspecifics. We discuss that voles can use the same type USVs in two different situations: of short-term isolation from conspecifics and during affiliative contacts in social groups. Call-eliciting procedure applied in this study is easy and potentially appropriate for pilot and comparative studies of USVs across species, including wild-type rodents without long experience of living under laboratory conditions.

与隔离、处理、配偶暴露或在中立领土上的同性互动引起的超声波呼叫相比，啮齿动物在与群体成员接触时产生的超声波呼叫（usv）研究得很少。在这项研究中，我们应用了一种程序来引出在永久社会群体中生活的两种Lasiopodomys田鼠的成年田鼠之间的接触所伴随的usv。各变量的基频和峰频值均显著高于野田葵，野田葵的usv持续时间是野田葵的2倍。与此同时，不同物种的usv在不同叫声轮廓、非线性现象和音符组成的发生上没有差异。在亲密接触时发出的usv在声学上与之前描述的这两个物种在与同种动物短期隔离的情况下发出的低频usv几乎相同。我们讨论了田鼠可以在两种不同的情况下使用相同类型的usv：与同种动物的短期隔离和在社会群体中的从属接触。本研究中使用的呼叫引出程序很容易，并且可能适用于跨物种的usv试点和比较研究，包括没有长期在实验室条件下生活经验的野生型啮齿动物。

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引用次数: 0

Audiovisual integration of faces and voices in Chinese individuals with social anxiety 中国社交焦虑个体面孔和声音的视听整合

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-30 DOI: 10.1016/j.bbr.2025.115905

Jing Yuan , Xianghui Liu , Xiaoli Chen , Mengyi Li , Zejun Liu , Bing Li

In our daily lives, we perceive the emotions of others usually through a variety of modalities such as faces, voices, gestures, etc. However, very few studies have investigated the multisensory integration of emotional information. In the current study, we aimed to explored the audiovisual integration of faces and voices in individuals with social anxiety. In Experiment 1, individuals with social anxiety disorder (SAD) and healthy controls (HCs) participated in an emotion categorisation task using static angry and happy faces and voices. The results showed that for angry emotion, compared to auditory stimuli, the SAD group took shorter to categorise audiovisual stimuli; while the HC group took shorter to categorise audiovisual stimuli than visual stimuli. In Experiment 2, We replaced static faces with dynamic faces. The results showed that facilitation effects of audiovisual integration for angry emotion in both groups. In addition, we found that the SAD group took longer to identify the angry emotion with the audiovisual modality compared to the HC group. However, these effects were only observed for reaction time, not accuracy. Our findings have implications for interventions for social anxiety.

在我们的日常生活中，我们通常通过各种方式感知他人的情绪，如面部、声音、手势等。然而，关于情绪信息的多感官整合的研究却很少。在本研究中，我们旨在探讨社交焦虑个体的面孔和声音的视听整合。在实验1中，患有社交焦虑障碍（SAD）的个体和健康对照（hc）的个体参与了一个使用静态愤怒和快乐面孔和声音的情绪分类任务。结果显示，对于愤怒情绪，与听觉刺激相比，SAD组对视听刺激进行分类的时间更短；而HC组对视听刺激的分类时间比视觉刺激短。在实验2中，我们用动态面代替静态面。结果表明，视听整合对两组愤怒情绪均有促进作用。此外，我们发现与HC组相比，SAD组用视听方式识别愤怒情绪所需的时间更长。然而，这些影响只观察到反应时间，而不是准确性。我们的发现对社会焦虑的干预具有启示意义。

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引用次数: 0

Dynamics of ACC excitatory neurons during reversal learning: Implications for cognitive flexibility 逆向学习过程中ACC兴奋性神经元的动态：对认知灵活性的影响。

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research

Pub Date : 2025-10-28 DOI: 10.1016/j.bbr.2025.115902

Meng Zhang , Fanzhi Shen , Chongzheng Liao , Shuai Liu , Huimin Wang , Chunxia Li

Cognitive flexibility, a core component of adaptive behavior, enables individuals to adjust their actions when environmental contingencies change and is frequently impaired in neuropsychiatric conditions such as obsessive-compulsive disorder (OCD) and autism spectrum disorder (ASD). The anterior cingulate cortex (ACC), known to support error monitoring, action-outcome evaluation, and rule updating, has been implicated in cognitive flexibility, yet the precise role of its excitatory neurons remains unclear. Using fiber photometry in a touchscreen-based task, we monitored ACC excitatory neuron activity in mice during discrimination and reversal learning to test whether their activity varies across learning stages and relates to behavioral adaptation. By analyzing calcium dynamics in a ± 1-second window around the reward-seeking nosepoke, we found that ACC activity increased significantly during incorrect trials compared to correct trials, specifically in the middle phase of reversal learning. Moreover, the magnitude of ACC activity in both correct and incorrect trials correlated positively with task accuracy and negatively with the number of correction trials, respectively, highlighting a strong link between ACC engagement and adaptive performance during this critical transition phase. These results suggest that ACC excitatory neurons may contribute to performance monitoring and rule updating rather than merely encoding trial outcomes. Together, our findings underscore a temporally specific role for ACC excitatory neurons in cognitive flexibility and may inform future therapeutic strategies targeting ACC-related dysfunction in disorders of behavioral rigidity.

认知灵活性是适应性行为的核心组成部分，它使个体能够在环境突发事件发生变化时调整自己的行为，在强迫症（OCD）和自闭症谱系障碍（ASD）等神经精神疾病中经常受到损害。前扣带皮层（ACC）支持错误监测、行为结果评估和规则更新，与认知灵活性有关，但其兴奋性神经元的确切作用尚不清楚。在基于触摸屏的任务中使用纤维光度法，我们监测了小鼠在辨别和反转学习期间ACC兴奋性神经元的活动，以测试它们的活动是否在学习阶段不同以及与行为适应有关。通过分析奖励鼻突周围±1秒窗口内的钙动力学，我们发现在不正确的实验中，与正确的实验相比，ACC活性显著增加，特别是在反转学习的中期。此外，在正确和错误试验中，前扣带皮层活动的大小分别与任务准确性呈正相关，与纠正试验的次数负相关，这表明在这一关键过渡阶段，前扣带皮层参与与适应性表现之间存在密切联系。这些结果表明，ACC兴奋性神经元可能有助于性能监测和规则更新，而不仅仅是编码试验结果。总之，我们的研究结果强调了ACC兴奋性神经元在认知灵活性中的暂时特异性作用，并可能为未来针对行为僵硬障碍中ACC相关功能障碍的治疗策略提供信息。

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引用次数: 0