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Glioblastoma multiforme (GBM) is a highly aggressive and treatment-resistant brain tumor, highlighting the need for novel therapeutic strategies. Therefore, it is of interest to investigate the anti-cancer effects of Arsenicum iodatum and Arsenicum album in U87 glioblastoma cells at 6C, 12C and 30C potencies. Both preparations induced apoptosis, confirmed by TUNEL along with the caspase-3 assays and triggered autophagy, evidenced by reduced p62 levels. Inhibition of autophagy enhanced cytotoxicity, indicating its protective role in GBM cells. Thus, we show that Arsenicum iodatum and Arsenicum album may serve as complementary candidates for GBM therapy, warranting further in vivo and mechanistic studies.

Mastoid osteoma is a benign osteoblastic tumour with a low incidence and has rarely been documented in childhood and adolescence. It manifests as a solitary lesion and the size rarely exceeds 3 cm at the time of presentation. The diagnosis is based on clinical and radiological findings. Complete excision of the tumour is the recommended treatment, based on the cosmetic concerns. We report a case of a giant mastoid osteoma in an 11-year-old female and outline its presentation, diagnosis and management.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune condition that has increase appreciated cardiovascular and neurovascular complications. This report presents a cross-sectional study of 100 SLE patients (18-55 years) who were evaluated for the prevalence and relationship of subclinical atherosclerosis and cognitive dysfunction. Subclinical atherosclerosis was measured by carotid intima-media thickness (CIMT) and cognition was measured by scoring the Montreal Cognitive Assessment (MoCA). The study found that 36% of participants had subclinical atherosclerosis, while 42% had cognitive impairment. Both subclinical atherosclerosis and cognitive dysfunction were associated with longer disease duration, corticosteroid exposure, higher SLEDAI scores and the presence of antiphospholipid antibodies. Data shows the high prevalence of concomitant vascular and cognitive dysfunction in SLE patients and the need for early screening for both outcomes in a non-invasive manner.

Penetrating injuries to the brain, due to low-velocity, non-missile objects are rare in civilian lament, but can carry significant morbidity. We describe a 20-year-old male with altered sensorium, headache and imbalance, months following what was deemed a trivial head injury from cricket. After imaging, a 2.5 cm metallic splinter lodged in the left cerebellum, which was subsequently surgically removed. The patient developed meningitis and hydrocephalus, required a shunt thereafter, but was complicated by the development of a pseudocyst, cherry-picking a CSF leak, malfunction of the original shunt and he ultimately had to be managed with a ventriculoarterial shunt. Thus, the need for routine imaging, expedited clinical recognition and individual management of delayed complications for penetrating injuries with the brain.

Recurrence of non-muscle invasive bladder cancer (NMIBC) remains a major clinical challenge despite advances in diagnosis and treatment. Hence, this case-control study evaluated the influence of lifestyle factors on NMIBC recurrence among 120 patients. Dietary habits, smoking, alcohol consumption, and physical activity were analyzed using structured questionnaires. Patients with recurrence showed higher rates of smoking, sedentary lifestyle, and processed meat intake. Multivariate analysis identified these factors as independent predictors, suggesting that targeted lifestyle modification may help reduce recurrence risk.

Clinical dental photography has become an integral part of dentistry, aiding documentation, patient education, treatment planning and aftercare. With advances in digital technology, both students and practitioners widely use dental photography, significantly influencing clinical practice. Therefore, it is of interest to assess the extent of use, knowledge and ethical perceptions of dental photography among dental practitioners and students through a structured questionnaire survey. An observational cross-sectional online survey was conducted and statistical analysis revealed no significant differences in knowledge between experienced clinicians and students. While dental photography is widely adopted for documentation and patient motivation, there remains a need to strengthen technical skills and ethical awareness to optimize its role in practice.

Thorough elimination of pulp tissue remnants and significant reduction of microbial pathogens within the root canal system are essential for the success of endodontic treatment. Therefore, it is of interest to compare and assess the effectiveness of 10% boric acid, 5% boric acid and 5.25% NaOCl in dissolving pulp tissue. Forty pulp tissue samples obtained during routine endodontic procedures were standardized to 25 mg each, evenly distributed into four groups (n=10 per group). The initial weight of the samples was recorded using an analytical balance and each sample was then immersed in 5 ml of the respective solution for 30 minutes at room temperature. After immersion, the samples were re-weighed and the weight loss was recorded and analyzed.

Medication-related osteonecrosis of the jaw (MRONJ) remains a significant clinical challenge due to its complex etiology and variable response to treatment. This prospective observational study evaluated the effectiveness of current management protocols in 130 patients receiving antiresorptive or antiangiogenic therapies. Patients were assessed clinically and radiographically and treated according to standardized stage-specific guidelines. Combined conservative and surgical interventions achieved better healing rates, symptom control, and improved quality of life over 12 months. These findings support ongoing refinement of stage-based MRONJ protocols to optimize therapeutic outcomes and patient care.

Bone cement implantation syndrome (BCIS) is a serious complication seen in cemented hip surgeries, causing hypoxia, hypotension and cardiovascular collapse but Indian studies on risk factors are limited. In this prospective study of 50 patients at MGM Medical College Indore, BCIS occurred in 20% cases (n=10), mostly mild Grade 1 (80%). Elderly patients (mean age 77.7 ± 4.6 years, p=0.001), ASA grade 3 (p=0.001), COPD (40%, p=0.001), hypertension (70%, p=0.012) and long-stem prosthesis (60%, p=0.006) showed higher risk. BCIS patients had significant fall in heart rate, BP and oxygen levels within first 30 minutes of cement insertion, needing urgent vasopressors and steroids. Gender, diabetes and fracture type were not linked to BCIS, highlighting the need for early identification and close monitoring in high-risk groups.

Chronic tympanic membrane perforations remain a frequent cause of hearing loss, and the optimal surgical approach for repair continues to be debated. This longitudinal comparative study evaluates graft success, hearing improvement, operative time, and complications between microscopic and endoscopic myringoplasty. Among patients studied, the endoscopic technique yielded greater hearing gain, reduced postoperative morbidity, and shorter hospital stay compared to the microscopic method. Although graft success was slightly higher in the endoscopic group (93.3% vs. 86.7%), complications were markedly fewer. Overall, endoscopic myringoplasty demonstrated superior efficiency, patient comfort, and satisfaction, supporting its advantage over the traditional microscopic approach.