Bioinformation最新文献

Stress is derived from the Latin word "stringers" manifests as the body's response to various demands and pressures, affecting individuals' health and well-being. Therefore, it is of interest to evaluate stress levels in employed and unemployed women, recognizing the differential stress experiences in various life domains. A quantitative non-experimental comparative research design was employed, with data collected through structured questionnaires from 120 women in Visnagar, Gujarat. Results: Non-working women demonstrated lower stress levels compared to working women in pre-test measures. Post-intervention, non-working women experienced a reduction in stress, while working women showed no change. Demographic factors like age, education, and family structure did not significantly influence stress levels, except for monthly income, which correlated with lower stress across both groups. The study underscores significant disparities in stress levels between employed and unemployed women in rural Visnagar. Tailored interventions effectively reduced stress among non-working women but showed limited efficacy for working women. Financial stability emerged as a crucial factor in mitigating stress. Younger working women reported higher stress levels, suggesting the need for targeted interventions addressing career and familial pressures.

Smoking has emerged as a predominant risk factor for coronary artery disease (CAD) in India, contributing significantly to the country's rising cardiovascular morbidity and mortality rates. The adverse effects of tobacco on cardiovascular health are well-documented, exacerbating a public health challenge in a nation with a high prevalence of smoking. Therefore, it is of interest to analyse the impact of smoking on the incidence and progression of coronary artery disease among the Indian population, emphasizing the need for targeted public health interventions to mitigate this risk factor. We included 1000 adults were enrolled from January to July 2023. The group comprised 500 CAD patients (cases) and 500 individuals without CAD (controls). We gathered information on demographics, smoking habits & other CAD risk factors. To assess the relationships between smoking, CAD, and other variables, we utilized multivariate logistic regression. The analysis revealed that current smokers had a substantially increased likelihood of CAD, with an unadjusted odds ratio (OR) of 3.20 (95% CI: 2.45-4.18), compared to non-smokers. This association remained significant even after adjusting for confounders, with an adjusted OR of 2.80 (95% CI: 2.10-3.75). The study confirms smoking as a critical, Adaptable risk element for CAD, independently increasing the risk of the disease. Smoking significantly elevates the risk of developing coronary artery disease among Indians. Comprehensive anti-smoking campaigns and stringent tobacco control policies are imperative to reduce the burden of CAD. Public health strategies must focus on awareness, prevention, and cessation support to combat this major health threat effectively.

Amla, scientifically known as emblica officinalis and Acerola (malphigian emarginata) both are Vitamin C fruits possess varied medicinal properties being used for preventive disease health management strategies. Therefore, it is of interest to explore the antioxidant, anti-inflammatory, antibacterial, and cytotoxic properties of aqueous extracts from Acerola and Amla. Hence, the anti-inflammatory activity of Acerola and amla was assessed using the bovine serum albumin denaturation assay (BSA Assay), antioxidant properties were compared using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Both extracts antibacterial activities were evaluated through the agar well diffusion technique against oral pathogens and Brine shrimp lethality assay for cytotoxicity. The current research sheds light on natural remedies for oxidative stress-related diseases, inflammatory conditions and bacterial infections, offering promising avenues for disease management and preventive healthcare strategies especially in the treatment of oral health diseases like periodontitis.

Herbal remedies have demonstrated remarkable effects as anti-diabetic, anticancer, antimicrobials, immunological modulatory agent in liver problems, respiratory illnesses, and as beauty agents. The need for more affordable, readily accessible, and alternative medicines has led to a rise in the recognition of herbal drugs. Therefore, it is of interest to evaluate and compare the effectiveness of photosensitized curcumin fibers, Aloevera, Amla Juice and Pancha Tulsi in disinfecting guttapercha (GP) cones. It was observed that all experimental disinfectants were found to have greater antimicrobial action than the positive control in which no disinfectant was used. The order of antimicrobial action among different experimental disinfectants against Staphylococcus aureus and Enterococcus faecalis in disinfection of GP cones was in following order PanchaTulsi>Curcumin fibers >Amla juice > Aloe vera. It was concluded that all herbal disinfectants were found to have antimicrobial effectiveness in disinfection of GP cones with Panchtulsi having maximum disinfectant ability followed by photosensitized curcumin fibres.

Orthodontists should know variation in thickness of infrazygomatic crest region according to maturation status of patients. Therefore, it is of interest to evaluate the thickness of bone at infrazygomatic crest region and to correlate the thickness of bone with cervical vertebrae maturation index (CVMI) incorporating CBCT.A retrospective analysis of 120 patients' CBCT scans60 of them male and 60 female-was carried out. The thickness of the bone was determined at five locations. Using CBCT, the cervical vertebral maturation was created and the Hassel-Farmann index was used for analysis. A lone researcher conducted all of the measurements. Bone thickness of infrazygomatic arch at all five locations was found to increase as the maturation stage progressed from initiation stage to maturation stage. Then there was decrease in the bone thickness in completion stages compared to maturation stage. The thickness of bone at infrazygomatic arch is significantly correlated with CVM stages as determined by CBCT.

Bone transplant with osteopromotive elements - such as herbal extracts - that promote the creation of new boneis of interest to dentists. Hence, we compared the bone loss around dental implants while placing platelet rich fibrin (PRF) scaffold alone and PRF scaffold with simvastatin (SIM) and PRF scaffold with Moringaoleifera (MO). There were thirty six patients total. A total of 36 implants, or twelve implants in all three categories, were the estimated sample size. Category 1: PRF scaffolds alone. Category 2: PRF scaffolds with SIM. Category 3: PRF scaffolds with MO. Alteration in the bones were measured with CBCT. It was observed that there was decreased loss of crestal bone in PRF+ SIM and PRF+MO as compared to PRF alone. The use of herbal osteopromotive agents like simvastitin and Moringaoleifera along with PRF scaffolds can be effective in reducing bone loss around dental implants.

The microbial profile of patients with periimplantis to inqure any unique composition of microorganisms in them is of interest to dentists. Hence, we evaluated the microbial profile of patients with peri-implantitis, patients with periodontitis and normal healthy subjects. 180 subjects were included in this study. Plaque samples were collected from 60periodontically healthy (PH) participants, 60 periodontitis (PT) subjects, and 60 periimplantitis (PI) subjects. Final concentrations were obtained for seven most common periodontal pathogens namely Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Treponema denticola, Porphyromonas gingivalis, Prevotella intermedia, Staphylococcus aureus and Haemophilus parainfluenzae. The abundance of microorganisms was represented in the form of Log10CFU (x103). The abundance of periopathogens evaluated in this research was different in periimplantitis patients, periodontitis patients and normal healthy subjects with slight greater abundance of peripathogens in patient with periimplantitis.

Light Amplified Stimulated Emission of Radiation (LASER) is nowadays widely studied regarding their use in endodontics and restorative dentistry. Therefore, it is of interest to evaluate the antibacterial activity of three types of LASERs namely CO2 LASER.Er, Cr:YSGG LASER and Diode LASER in disinfection of root canals. 70 patients (105 single rooted teeth) were included in the study. There was application of 2% Sodium Hypochlorite (NaOCl), 2780 nm Er,Cr:YSGG LASER, 900 nm Diode LASER and CO2 LASER. Microbial samples were collected from root canals both before and after the interventions through paper points. These parameters were evaluated in microbiology laboratory to obtain Log10 Colony Forming Units (CFUs). There was significant reduction in CFUs of microorganisms inside root canal in all three LASERs evaluated and NaOCl. The reduction in CFUs in LASERs was comparable to NaOCl. Then secondly we applied each LASER in combination with NaOCl. It was observed that reduction in CFU was greater when combination of LASER with NaOCl was applied as compared when applied alone. It can be inferred that LASER when applied with NaOCl can have significant role in disinfection of root canals.

Stress and anxiety may be found in patients with oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral lichen planus (OLP). Cortisol, sometimes referred to as the "stress hormone," has been employed as a stress predictor. Therefore, it is of interest to estimate the levels of depression, anxiety and serum cortisol and establish correlation between them in patients with OL. OLP and OSMF. There were 240 patients, aged 20 years to 45 years, who were divided into four categories (OL, OSMF, OLP and control) of 60 patients apiece. In the supervision of a psychiatrist, the Hamilton Depression Rating Scale (HAM D) and Hamilton Anxiety Rating Scale (HAM (A) questionnaires were filled out. Five millilitres of venous blood were extracted using standard aseptic technique, and all of the samples were examined for serum cortisol level. Anxiety and depression was found in subjects of OL, OSMF and OLP at advanced stages. It was inferred that serum cortisol level was statistically correlated with depression and anxiety in patients with OL, OSMF and OLP.

The amount of apically extruded debris following glide-path preparation of mesial root of 120 freshly extracted human mandibular molar teeth using Senseus ProFinder files, PathFile, G-Files, Scout-RaCe files, HyFlex glidepath files and V glide-path two file system is of interest. The Eppendorf tubes were used as test equipment for collecting debris and the average weight of the debris was measured using an electronic micro-balancing system. It was observed that regardless of the file system utilized, debris was expelled from the apex. The G files resulted in a lower quantity of debris being extruded (0.070 ± 0.002 mg). In contrast, the V glide-path two file system exhibited the highest amount of debris extrusion (0.110 ± 0.004 mg) compared to all other file systems.