Being overweight and obese are risk factors that have increased during the COVID-19 pandemic; these factors increase the white adipose tissue (WAT) that increases the release of adipokines (adiponectin, leptin, and resistin). So, obesity provokes the expansion of adipose tissue; it induces changes in their macrophages of pro-inflammatory cytokines (M2 to M1). These changes increase the resistin levels with effects on the metabolism, inflammation process, glucose homeostasis, and insulin resistance, promote cell proliferation and migration, and even serve as a biomarker for tumorigenesis. Therefore, resistin is proposed as a multipotential therapeutic target to treat different diseases, between chronic-degenerative and some types of cancer, because resistin has characteristics that give it a high probability to be a therapeutic target to attend to and prevent various diseases. In different ways, developing new drugs by molecular docking to use molecules with pharmacological characteristics capable of interacting in the regions of resistin to hinder/block the interaction between resistin and their receptors (Δ-DCN, TLR4, and CAP-1) and by promoting health to reduce overweight and obesity, and this could generate lower plasma serum resistin values, so this review remarks the potential of resistin as multipotential therapeutic target.
{"title":"Resistin, a Multipotential Therapeutic Target","authors":"J. L. Vique‐Sánchez","doi":"10.33263/briac134.384","DOIUrl":"https://doi.org/10.33263/briac134.384","url":null,"abstract":"Being overweight and obese are risk factors that have increased during the COVID-19 pandemic; these factors increase the white adipose tissue (WAT) that increases the release of adipokines (adiponectin, leptin, and resistin). So, obesity provokes the expansion of adipose tissue; it induces changes in their macrophages of pro-inflammatory cytokines (M2 to M1). These changes increase the resistin levels with effects on the metabolism, inflammation process, glucose homeostasis, and insulin resistance, promote cell proliferation and migration, and even serve as a biomarker for tumorigenesis. Therefore, resistin is proposed as a multipotential therapeutic target to treat different diseases, between chronic-degenerative and some types of cancer, because resistin has characteristics that give it a high probability to be a therapeutic target to attend to and prevent various diseases. In different ways, developing new drugs by molecular docking to use molecules with pharmacological characteristics capable of interacting in the regions of resistin to hinder/block the interaction between resistin and their receptors (Δ-DCN, TLR4, and CAP-1) and by promoting health to reduce overweight and obesity, and this could generate lower plasma serum resistin values, so this review remarks the potential of resistin as multipotential therapeutic target.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43921731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CO2 corrosion has emanated as a significant concern in the oil/gas industry owing to the aging of its oilfields. Thus, corrosion protection is significant for maintaining the integrity and sustainability of pipelines, surface facilities, and downhole tools in the oil/gas sector. The present study evaluates the corrosion inhibitory properties of three oxazolone derivatives in CO2 saturated 3.5 weight% NaCl solution against API5LX60 carbon steel used in certain wells and oil/ gas transportation pipelines. The inhibitory behavior was investigated utilizing gravimetric and electrochemical techniques viz. EIS, PDP, and LPR. Electrochemical and Gravimetric technique results were in congruence. EIS asserts capacitive behavior, and PDP affirms oxazolones as mixed inhibitors. SEM and SEM-EDX confirmed the formation of a protective layer by adsorption. At an optimum inhibitor concentration of 200 ppm, inhibitor I exhibited 91.30% inhibition—linear correlation coefficient R2 value of 0.99 avowed adsorptions via Langmuir Isotherm.
{"title":"Corrosion Inhibition Investigation of Small Organic Inhibitor on API5LX60 Steel in 3.5% NaCl Solution with CO2 Saturation","authors":"","doi":"10.33263/briac134.380","DOIUrl":"https://doi.org/10.33263/briac134.380","url":null,"abstract":"CO2 corrosion has emanated as a significant concern in the oil/gas industry owing to the aging of its oilfields. Thus, corrosion protection is significant for maintaining the integrity and sustainability of pipelines, surface facilities, and downhole tools in the oil/gas sector. The present study evaluates the corrosion inhibitory properties of three oxazolone derivatives in CO2 saturated 3.5 weight% NaCl solution against API5LX60 carbon steel used in certain wells and oil/ gas transportation pipelines. The inhibitory behavior was investigated utilizing gravimetric and electrochemical techniques viz. EIS, PDP, and LPR. Electrochemical and Gravimetric technique results were in congruence. EIS asserts capacitive behavior, and PDP affirms oxazolones as mixed inhibitors. SEM and SEM-EDX confirmed the formation of a protective layer by adsorption. At an optimum inhibitor concentration of 200 ppm, inhibitor I exhibited 91.30% inhibition—linear correlation coefficient R2 value of 0.99 avowed adsorptions via Langmuir Isotherm.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46960207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous studies have demonstrated the potential anticancer effect of quercetin (QUR). However, water insolubility and less bioavailability of QUR reduce its efficiency in cancer therapy. So, this study aims to develop a nanoformulation of quercetin (QURnp) and evaluate its anticancer effect against Ehrlich ascites carcinoma (EAC)-bearing mice compared with native QUR. QUR- loaded pluronic nanoparticles (QURnp) were prepared and characterized. To investigate the anticancer effect of QUR and QURnp, histopathological, ultrastructural, immunohistochemical, cell cycle analysis, western blot, and qRT-PCR studies were performed on EAC tumor cells, as well as antioxidant biomarkers. The results showed that QURnp destroyed tumor cells and significantly elevated antioxidant status with the reduction in MDA and NO levels. QURnp caused mitochondrial degeneration in tumor cells. Furthermore, QURnp completely reduced tumor growth by inhibiting the IL-6/STAT3 signaling pathway, inducing cell cycle arrest at the G1/S phase via overexpression of p27 and suppression of angiogenesis via downregulation in VEGF gene expression. Moreover, immunohistochemical studies indicated that QURnp showed significant inhibition of proliferation marker Ki-67 and anti-apoptotic marker Bcl-2. This study demonstrated that QURnp is a promising anticancer agent superior to native QUR.
{"title":"Newly Modified Nanoformulation of Quercetin as Promising Chemotherapeutic Anticancer Agent","authors":"","doi":"10.33263/briac134.387","DOIUrl":"https://doi.org/10.33263/briac134.387","url":null,"abstract":"Previous studies have demonstrated the potential anticancer effect of quercetin (QUR). However, water insolubility and less bioavailability of QUR reduce its efficiency in cancer therapy. So, this study aims to develop a nanoformulation of quercetin (QURnp) and evaluate its anticancer effect against Ehrlich ascites carcinoma (EAC)-bearing mice compared with native QUR. QUR- loaded pluronic nanoparticles (QURnp) were prepared and characterized. To investigate the anticancer effect of QUR and QURnp, histopathological, ultrastructural, immunohistochemical, cell cycle analysis, western blot, and qRT-PCR studies were performed on EAC tumor cells, as well as antioxidant biomarkers. The results showed that QURnp destroyed tumor cells and significantly elevated antioxidant status with the reduction in MDA and NO levels. QURnp caused mitochondrial degeneration in tumor cells. Furthermore, QURnp completely reduced tumor growth by inhibiting the IL-6/STAT3 signaling pathway, inducing cell cycle arrest at the G1/S phase via overexpression of p27 and suppression of angiogenesis via downregulation in VEGF gene expression. Moreover, immunohistochemical studies indicated that QURnp showed significant inhibition of proliferation marker Ki-67 and anti-apoptotic marker Bcl-2. This study demonstrated that QURnp is a promising anticancer agent superior to native QUR.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45201873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Here, we report the facile synthesis of graphene oxide/gold nanocomposite, and dye removal ability as an adsorbent was studied. Sodium citrate as a reducing agent was used to reduce Au (III) ions to the formation of gold nanoparticles on the surface of graphene oxide sheets that were prepared by Hummers’ method. Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) was used to specify nanocomposite synthesis. Adsorption dosage and contact time were investigated and explained as influencing parameters in removing methylene blue and methyl orange. In optimum conditions, the amount of adsorbent 30 mg and contact time 15 min for methylene blue and the amount of adsorbent 30 mg and contact time 25 min for methyl orange were quantitatively removed from 10 mL of wastewater. The pseudo-second-order model explained the kinetic data. Since graphene oxide/gold nanocomposite could be reused reasonably and had adsorptive properties, it tends to be produced as a modest and elective adsorbent to treat wastewater.
{"title":"Synthesis, Characterization, and Dye Removal Applications of Graphene Oxide-Gold Nanocomposite","authors":"","doi":"10.33263/briac134.385","DOIUrl":"https://doi.org/10.33263/briac134.385","url":null,"abstract":"Here, we report the facile synthesis of graphene oxide/gold nanocomposite, and dye removal ability as an adsorbent was studied. Sodium citrate as a reducing agent was used to reduce Au (III) ions to the formation of gold nanoparticles on the surface of graphene oxide sheets that were prepared by Hummers’ method. Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) was used to specify nanocomposite synthesis. Adsorption dosage and contact time were investigated and explained as influencing parameters in removing methylene blue and methyl orange. In optimum conditions, the amount of adsorbent 30 mg and contact time 15 min for methylene blue and the amount of adsorbent 30 mg and contact time 25 min for methyl orange were quantitatively removed from 10 mL of wastewater. The pseudo-second-order model explained the kinetic data. Since graphene oxide/gold nanocomposite could be reused reasonably and had adsorptive properties, it tends to be produced as a modest and elective adsorbent to treat wastewater.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45339720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main objective is to find a suitable and effective solution to strengthen agglomerated paper fibers and improve their physical, mechanical, and chemical properties. Many reasons lead to petrification and sticking papers. The alone worker can't lead to petrification and damage because all deterioration factors participate in the provisions of the damage circle on papers. The possible end is the loss of parts or parts or the annihilation of the entire manuscript or book. Given the archaeological and artistic value of the paper manuscripts, hydroxypropyl cellulose was chosen because it is a paper-friendly material. The papers are subject to artificial aging to reach an age like the age of the fossilized manuscript. Then the samples were naturally aged by infecting them with A. niger until they reached adhesion and agglomeration. After that, a separation process was carried out for the leaves. The leaves were consolidated with 2% hydroxypropyl cellulose. Then, an evaluation was carried out to determine the effect of hydroxypropyl cellulose on paper using digital microscopy, scanning electron microscopy, mechanical properties measurement, color change measurement, FTIR measurement, and pH measurement. The results of the examination and evaluation revealed its success in strengthening the papers and improving their properties. Therefore, it was applied to manuscript papers dating back to the thirteenth century AD.
{"title":"Strengthening the Clumping Paper Properties using Hydroxypropyl Cellulose Applied on a Historical manuscript 13th Century AD.","authors":"","doi":"10.33263/briac134.375","DOIUrl":"https://doi.org/10.33263/briac134.375","url":null,"abstract":"The main objective is to find a suitable and effective solution to strengthen agglomerated paper fibers and improve their physical, mechanical, and chemical properties. Many reasons lead to petrification and sticking papers. The alone worker can't lead to petrification and damage because all deterioration factors participate in the provisions of the damage circle on papers. The possible end is the loss of parts or parts or the annihilation of the entire manuscript or book. Given the archaeological and artistic value of the paper manuscripts, hydroxypropyl cellulose was chosen because it is a paper-friendly material. The papers are subject to artificial aging to reach an age like the age of the fossilized manuscript. Then the samples were naturally aged by infecting them with A. niger until they reached adhesion and agglomeration. After that, a separation process was carried out for the leaves. The leaves were consolidated with 2% hydroxypropyl cellulose. Then, an evaluation was carried out to determine the effect of hydroxypropyl cellulose on paper using digital microscopy, scanning electron microscopy, mechanical properties measurement, color change measurement, FTIR measurement, and pH measurement. The results of the examination and evaluation revealed its success in strengthening the papers and improving their properties. Therefore, it was applied to manuscript papers dating back to the thirteenth century AD.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D-glucofuranose has potent bioactivity against numerous diseases and pathogens, such as bacteria, fungi, viruses, and cancer. Normally, the ketal form of D-glucofuranose is converted into the non-ketal form by drug metabolism in the human body; as a result, both the ketal and non-ketal forms of D-glucofuranose are considered. To make a comparative biological activity study of ketal and non-ketal species of nine derivatives of D-glucofuranose, two bacteria, black fungus, white fungus, and triple-negative breast cancer, were selected. Firstly, the PASS prediction data from the online PASS tool indicated the probability of pathogenic efficacy through the Pa and Pi parameters. Secondly, the computational studies, such as molecular docking, molecular dynamic, ADMET, drug-likeness, pharmacokinetic, aquatic, and non-aquatic features, were calculated with three FDA-approved drugs, including azithromycin, nystatin, and cyclophosphamide. A comparative study of computational data has been performed where the ketal forms of D-glucofuranose derivatives were found highly biologically active with the satisfaction of the pharmacokinetic parameters, ADMET parameters, and Lipinski rule.
d -葡聚糖对许多疾病和病原体，如细菌、真菌、病毒和癌症具有强大的生物活性。正常情况下，d -葡聚糖在人体内通过药物代谢转化为非酮型;因此，考虑了d -葡萄糖葡萄糖的酮态和非酮态形式。以黑木耳、白木耳和三阴性乳腺癌两种细菌为研究对象，对九种d -葡聚糖衍生物的酮类和非酮类生物活性进行比较研究。首先，通过在线PASS工具的PASS预测数据，通过Pa和Pi参数表示致病功效的概率。其次，以阿奇霉素、制霉菌素、环磷酰胺3种fda批准的药物进行分子对接、分子动力学、ADMET、药物相似性、药代动力学、水生和非水生特征等计算研究。对计算数据进行了比较研究，发现d -葡聚糖衍生物的酮形具有高度的生物活性，符合药代动力学参数、ADMET参数和Lipinski规则。
{"title":"Quantum Calculation, Docking, ADMET and Molecular Dynamics of Ketal and Non-ketal Forms of D-glucofuranose Against Bacteria, Black & White Fungus, and Triple-Negative Breast Cancer","authors":"","doi":"10.33263/briac134.374","DOIUrl":"https://doi.org/10.33263/briac134.374","url":null,"abstract":"D-glucofuranose has potent bioactivity against numerous diseases and pathogens, such as bacteria, fungi, viruses, and cancer. Normally, the ketal form of D-glucofuranose is converted into the non-ketal form by drug metabolism in the human body; as a result, both the ketal and non-ketal forms of D-glucofuranose are considered. To make a comparative biological activity study of ketal and non-ketal species of nine derivatives of D-glucofuranose, two bacteria, black fungus, white fungus, and triple-negative breast cancer, were selected. Firstly, the PASS prediction data from the online PASS tool indicated the probability of pathogenic efficacy through the Pa and Pi parameters. Secondly, the computational studies, such as molecular docking, molecular dynamic, ADMET, drug-likeness, pharmacokinetic, aquatic, and non-aquatic features, were calculated with three FDA-approved drugs, including azithromycin, nystatin, and cyclophosphamide. A comparative study of computational data has been performed where the ketal forms of D-glucofuranose derivatives were found highly biologically active with the satisfaction of the pharmacokinetic parameters, ADMET parameters, and Lipinski rule.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41391910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Targeting angiotensin-converting enzyme (ACE) comes out to be an effective mechanism for controlling hypertension. Two-dimensional quantitative structural activity relationship models were generated to predict the ACE inhibitory activity of chalcone analogs. The genetic algorithm- multiple linear regression models (GA-MLR) approach was used to generate highly predictive models using straightforwardly interpretable Py, Estate, Alvadesc, and Padel descriptors. Application of Intelligent consensus modeling confirms that model-2 is statistically robust (R2tr = 0.66, Q2LOO = 0.5621) with good external predictivity (Concordance Correlation Coefficient, CCCex = 0.9109, Q2-F1 = 0.85818, Q2-F2 = 0.85782 and Q2-F3 = 0.88489). Novel analogs designed according to the synthetic route considering structural requirements indicated by the model were found to be satisfactory and could be considered for synthesis and subsequent screening.
{"title":"2D-QSAR Modeling of Chalcone Analogues as Angiotensin Converting Enzyme Inhibitor","authors":"","doi":"10.33263/briac134.370","DOIUrl":"https://doi.org/10.33263/briac134.370","url":null,"abstract":"Targeting angiotensin-converting enzyme (ACE) comes out to be an effective mechanism for controlling hypertension. Two-dimensional quantitative structural activity relationship models were generated to predict the ACE inhibitory activity of chalcone analogs. The genetic algorithm- multiple linear regression models (GA-MLR) approach was used to generate highly predictive models using straightforwardly interpretable Py, Estate, Alvadesc, and Padel descriptors. Application of Intelligent consensus modeling confirms that model-2 is statistically robust (R2tr = 0.66, Q2LOO = 0.5621) with good external predictivity (Concordance Correlation Coefficient, CCCex = 0.9109, Q2-F1 = 0.85818, Q2-F2 = 0.85782 and Q2-F3 = 0.88489). Novel analogs designed according to the synthetic route considering structural requirements indicated by the model were found to be satisfactory and could be considered for synthesis and subsequent screening.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48405642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The approach of using existing drugs initially developed for one disease to treat other indications has found success across medical fields. This article emphasizes the drug repurposing of 9H-thioxanthene based on FDA-approved drugs for anticancer agents precisely targeting VEGFR-2 and COX-2. The investigated 9H-thioxanthene drugs 1-4 were analyzed for Lipinski's drug-likeness rule and ideal ADME parameters. The results show that all calculated physicochemical descriptors and pharmacokinetic properties are within the expected range. 9H-thioxanthene drugs 1-4 were subjected to molecular docking to determine their molecular interactions at the active sites of VEGFR-2 and COX-2. The molecular docking study revealed that all four 9H-thioxanthene drugs 1-4 were able to target VEGFR-2 and COX-2. In the future, these findings will be greatly favorable in augmenting the utility of the development of the investigated drugs 1-4 for cancer therapeutics specifically targeting VEGFR-2 and COX-2.
{"title":"In Silico Drug Repurposing of 9H-Thioxanthene Based FDA-Approved Drugs as Potent Chemotherapeutics Targeting VEGFR-2 and COX-2","authors":"","doi":"10.33263/briac134.372","DOIUrl":"https://doi.org/10.33263/briac134.372","url":null,"abstract":"The approach of using existing drugs initially developed for one disease to treat other indications has found success across medical fields. This article emphasizes the drug repurposing of 9H-thioxanthene based on FDA-approved drugs for anticancer agents precisely targeting VEGFR-2 and COX-2. The investigated 9H-thioxanthene drugs 1-4 were analyzed for Lipinski's drug-likeness rule and ideal ADME parameters. The results show that all calculated physicochemical descriptors and pharmacokinetic properties are within the expected range. 9H-thioxanthene drugs 1-4 were subjected to molecular docking to determine their molecular interactions at the active sites of VEGFR-2 and COX-2. The molecular docking study revealed that all four 9H-thioxanthene drugs 1-4 were able to target VEGFR-2 and COX-2. In the future, these findings will be greatly favorable in augmenting the utility of the development of the investigated drugs 1-4 for cancer therapeutics specifically targeting VEGFR-2 and COX-2.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48102580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the last three decades, there has been wide progress in nanomaterials development, and several studies are being performed to show its biological effects and cellular interaction for biomedical applications. Due to the exponential increase in nanomaterial diversity, production, and possibilities of applications in different areas, there is an important concern about its toxicity for humans, animals, and ecosystems. There is a great effort to minimize experimental assays in animals, and this is a commendable initiative. Several alternatives in vitro assays are available; however, several new protocols have been introduced to elucidate the mechanisms of cell-nanomaterial interaction. Wide and fast progress in nanotechnology has been observed. Nonetheless, the nanomaterial interaction with cells or biological systems is still not totally described. In this aspect, this paper is a brief overview of nanomaterials and cellular interactions (nano-bio interaction).
{"title":"Overview of Nanomaterials and Cellular Interactions","authors":"","doi":"10.33263/briac134.367","DOIUrl":"https://doi.org/10.33263/briac134.367","url":null,"abstract":"In the last three decades, there has been wide progress in nanomaterials development, and several studies are being performed to show its biological effects and cellular interaction for biomedical applications. Due to the exponential increase in nanomaterial diversity, production, and possibilities of applications in different areas, there is an important concern about its toxicity for humans, animals, and ecosystems. There is a great effort to minimize experimental assays in animals, and this is a commendable initiative. Several alternatives in vitro assays are available; however, several new protocols have been introduced to elucidate the mechanisms of cell-nanomaterial interaction. Wide and fast progress in nanotechnology has been observed. Nonetheless, the nanomaterial interaction with cells or biological systems is still not totally described. In this aspect, this paper is a brief overview of nanomaterials and cellular interactions (nano-bio interaction).","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43745198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Novel 2-aminomethyl benzimidazole (AMBI) ruthenium complexes were synthesized and thoroughly characterized by elemental analysis, spectroscopy (FTIR, 1HNMR, UV–Vis), magnetic measurements, molar conductivity, and thermal analysis techniques. According to analytical data, all complexes demonstrated a 1:1 metal-to-ligand ratio with an octahedral shape. Thermal analysis showed that the complexes have acceptable thermal stability. Cyclic voltammetry was also used to observe their redox actions, and it was found that all of the complexes had electrochemical activity. Using GAUSSIAN 09 W software, the density functional theory (DFT) method and the 3-21G basis set, optimized structures (HOMO & LUMO) of ruthenium complexes (1-4) were carried out. Additionally, the selected quantum and geometric parameters of bond lengths and angles have been determined. The antimicrobial activity of ligand and ruthenium complexes has been evaluated against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans). Two human cancers, HePG-2(hepatocellular carcinoma) and MCF-7 (Michigan Cancer Foundation-7), were tested for cytotoxic activity of complexes. Using the ABTS technique, the antioxidant function of complexes was evaluated. Using a high-affinity Fab sandwich and a specific PCa antibody, molecular docking was utilized to anticipate how the ligand would bind to a human prostate-specific antigen (PSA) immune system receptor (3qum).
{"title":"Structural, Characterization, Biological Activity, and DFT Studies on some Novel Ruthenium 2-Aminomethyl Benzimidazole Complexes","authors":"","doi":"10.33263/briac134.365","DOIUrl":"https://doi.org/10.33263/briac134.365","url":null,"abstract":"Novel 2-aminomethyl benzimidazole (AMBI) ruthenium complexes were synthesized and thoroughly characterized by elemental analysis, spectroscopy (FTIR, 1HNMR, UV–Vis), magnetic measurements, molar conductivity, and thermal analysis techniques. According to analytical data, all complexes demonstrated a 1:1 metal-to-ligand ratio with an octahedral shape. Thermal analysis showed that the complexes have acceptable thermal stability. Cyclic voltammetry was also used to observe their redox actions, and it was found that all of the complexes had electrochemical activity. Using GAUSSIAN 09 W software, the density functional theory (DFT) method and the 3-21G basis set, optimized structures (HOMO & LUMO) of ruthenium complexes (1-4) were carried out. Additionally, the selected quantum and geometric parameters of bond lengths and angles have been determined. The antimicrobial activity of ligand and ruthenium complexes has been evaluated against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans). Two human cancers, HePG-2(hepatocellular carcinoma) and MCF-7 (Michigan Cancer Foundation-7), were tested for cytotoxic activity of complexes. Using the ABTS technique, the antioxidant function of complexes was evaluated. Using a high-affinity Fab sandwich and a specific PCa antibody, molecular docking was utilized to anticipate how the ligand would bind to a human prostate-specific antigen (PSA) immune system receptor (3qum).","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42915802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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