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Treating macular edema secondary to retinal vein occlusion with suprachoroidal injection of triamcinolone acetonide using custom made needle 定制针在脉络膜上注射曲安奈德治疗视网膜静脉阻塞继发黄斑水肿
Pub Date : 2018-10-22 DOI: 10.15406/AOVS.2018.08.00321
A. Marashi
Treatment of cystoid macular edema secondary to retinal vein occlusion used to be laser1 then intravitreal triamcinolone was used for the treatment2 today monthly intravitreal vascular endothelial growth factor blockage agents are used as first line therapy, as they showed efficacy and safety,3 however there are intravitreal steroids (dexamethasone or fluocinolone) in a form of implants (slow release devices) has shown durability and efficacy4 especially in cases where intravitreal VEGF blockage agents are contraindicated or nonresponsive mainly in cases where inflammatory cascade is the main pathological element.
对于继发于视网膜静脉阻塞的囊样黄斑水肿,过去采用激光治疗1,后来采用玻璃体内曲安奈德治疗2,目前采用每月一次的玻璃体内血管内皮生长因子阻滞剂作为一线治疗。由于它们显示出有效性和安全性,然而,玻璃体内类固醇(地塞米松或氟西诺酮)以一种植入形式(缓释装置)显示出持久性和有效性,特别是在玻璃体内VEGF阻断剂禁忌或无反应的情况下,主要是在炎症级联是主要病理因素的情况下。
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引用次数: 0
Integrity of the nerve fiber layer of the retina in Alzheimer’s disease 阿尔茨海默病视网膜神经纤维层的完整性
Pub Date : 2018-10-17 DOI: 10.15406/AOVS.2018.08.00320
Pires Jwl, Andrade Ep
With the increase in the life expectancy of the world population there was a greater attention to the diagnosis and treatment of neurodegenerative diseases. Although there is an exponential increase in the number of neuroprotective drugs for diseases, the inverse is seen in relation to the biomarkers and diagnostic neurodegenerative process. Among the neurodegenerative diseases associated with age, Alzheimer’s disease is the most frequent, with cognitive and neuropsychiatric disorders resulting in progressive disability and eventual incapacitation.1,2
随着世界人口预期寿命的增加,人们更加重视神经退行性疾病的诊断和治疗。尽管疾病的神经保护药物数量呈指数增长,但与生物标志物和诊断神经退行性过程相关的情况却相反。在与年龄相关的神经退行性疾病中,阿尔茨海默病是最常见的,伴有认知和神经精神疾病,导致进行性残疾和最终丧失能力1,2
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引用次数: 0
Femtosecond laser assisted cataract surgery 飞秒激光辅助白内障手术
Pub Date : 2018-10-09 DOI: 10.15406/aovs.2018.08.00319
B. DeBroff
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引用次数: 0
Remembering the Modified Lincoff ’s rules for practical identification of retinal break in regmatogenous retinal detachment 记住修正的Lincoff规则在视网膜脱离中视网膜破裂的实际识别
Pub Date : 2018-10-04 DOI: 10.15406/aovs.2018.08.00318
B. Turgut
and find small-dimensioned or hidden RBs in thin, folded and clear retina may sometimes be difficult. Intraoperative visualization of the peripheral retina in pars plana vitrectomy (PPV) may provide to detect these. However, each RB cannot be detected even during careful peripheral retinal examination with indentation. The detection of the RB is the first stage of the management of RRD. Possible localizations of RBs in the eyes with RRD are supero temporal (60%), superonasal (15%), inferotemporal (15%) and inferonasal (10%) quadrants. Additionally, it should not forget that there is more than one RB, and it is often within 90° of each other in about 50% of the eyes with RRD. RBs in pseudophakic eyes are almost invariably anterior to the equator.1 In most cases, RBs can be detected through Lincoff’s rules before the surgery. Although the application of these rules has been not used as much as in the past, I think that Lincoff’s rules should be taken into account again in the identification of the RBs. Modified Lincoff’s rules are rules to detection of primary RBs based on the configuration of sub retinal fluid (SRF) and the localisation of RRD in retrospective analysis of 1,000 cases of RD.1 In a recent study, it has been reported that anterior RBs and posterior vitreous detachment (PVD) have a significant association with validity of Lincoff rules.2 It has been reported that these rules are conformed to 96% of cases with primary RRD. Modified Lincoff’s rules include followings:1, 3‒6
在薄、折叠和透明的视网膜中发现小尺寸或隐藏的RBs有时可能很困难。术中观察睫状体部玻璃体切除术(PPV)的周围视网膜可能有助于检测这些病变。然而,每个RB不能被检测到,即使在仔细的视网膜周围检查与压痕。RB的检测是RRD管理的第一步。RRD患者眼内可能的RBs定位为颞上象限(60%)、鼻上象限(15%)、颞下象限(15%)和鼻下象限(10%)。此外,不要忘记有不止一个RB,并且在大约50%的RRD眼睛中,它们之间的距离通常在90°以内。假性晶状体眼几乎总是位于赤道的前方在大多数情况下,RBs可以在手术前通过Lincoff规则检测到。虽然这些规则的应用已经不像过去那样多了,但我认为在识别RBs时应该再次考虑Lincoff的规则。修正Lincoff规则是基于视网膜下液(SRF)的配置和RRD的定位对1000例rd进行回顾性分析的原发性RBs的检测规则。在最近的一项研究中,报道了前RBs和后玻璃体脱离(PVD)与Lincoff规则的有效性有显著相关据报道,这些规则符合96%的原发性RRD病例。修改后的Lincoff规则包括:1,3 - 6
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引用次数: 1
The distribution of subspecialties in ophthalmology group practices in an era of change group practices in an era of change 变革时代的眼科群诊亚专科分布
Pub Date : 2018-09-06 DOI: 10.15406/aovs.2018.08.00317
M. M. Palmisano, P. Palmisano
cohort expanded, but this trend is expected to continue for the next 30years.5 The cost of medical equipment is particularly high in the field of Ophthalmology and reimbursements for services are expected to decrease, putting tremendous pressure on practices to handle these challenges.4,5,16 It is difficult to determine how to staff a multi-subspecialty practice in this environment. The decision to hire a subspecialist involves weighing many factors including patient demand, reimbursement, the availability of physician applicants, competitive salaries, and the synergistic effects that the new physician may have on the group practice.
人数在增加,但这一趋势预计将持续30年眼科领域的医疗设备成本特别高,预计服务报销将减少,这给应对这些挑战的做法带来巨大压力。4,5,16在这种环境下,很难确定如何为多专科实践提供人员。决定聘请一名专科医生需要权衡许多因素,包括患者需求、报销、医生申请人的可用性、有竞争力的薪水以及新医生可能对团队实践产生的协同效应。
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引用次数: 2
A review on punctum plugs in the management of dry eye syndrome 干眼综合征治疗中点塞的研究进展
Pub Date : 2018-08-27 DOI: 10.15406/aovs.2018.08.00316
Amrish Kumar, V. Ashwlayan, Mansi Verma, V. Garg, S. Gupta
With estimated prevalence ranging from 7.8% to 93.2% from different studies worldwide, dry eye disease is probably the most common ocular condition seen by eye care practitioners.1‒4 Apparently, Asian studies report higher prevalence than those from western countries and the 3 studies from India report the prevalence between 18.4% and 40.8%. Despite the common use of the term dry eye in ophthalmic literature, there was no formal definition of dry eye was proposed as 1995. The currently used definition of dry eye was proposed by the 2007 International dry eye Workshop, dry eye is a multi-factorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface.5
根据全球不同的研究,干眼病的患病率估计在7.8%到93.2%之间,干眼病可能是眼科医生最常见的眼病。1-4显然,亚洲研究报告的患病率高于西方国家,印度的3项研究报告的患病率在18.4%至40.8%之间。尽管在眼科文献中经常使用“干眼症”一词,但直到1995年才提出干眼症的正式定义。目前使用的干眼定义是2007年国际干眼研讨会提出的,干眼是一种眼泪和眼表的多因素疾病,可导致不适、视力障碍和泪膜不稳定等症状,并可能对眼表造成损害。伴有泪膜渗透性增高和眼表炎症
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引用次数: 1
Annular keratectomy assisted by femto second laser: a case report 飞秒激光辅助环形角膜切除术1例
Pub Date : 2018-08-13 DOI: 10.15406/aovs.2018.08.00314
C. Orlich
keratoconus is a multifactorial corneal degeneration. It commonly presents with corneal thinning, irregular astigmatism and poor vision that generally does not improve with glasses and typically requires the use of contact lenses. It appears in pediatric patients, adolescents and young adults and very rarely presents itself in individuals older than 35.1 In developing countries, it is one of the principal indications for a full thickness corneal graft. In these countries, it is generally difficult to obtain tissue, generating long waiting lists for corneal transplants. Fortunately, the number of penetrating keratoplasties for keratoconus has decreased in recent years thanks to earlier detection of the disease and new treatment options. Professor Theo Seiler discovered corneal collagen cross-linking (CXL) at the end of the 1990’s at Dresden Technical University in Germany. The FDA has approved it in the US. It is indicated most in young patients with evidence of progressive keratoconus, the principal purpose of CXL is to avoid progression.2 The intracorneal segments may be very effective in regularizing the cornea and improving the astigmatic component, especially when assisted by the femtosecond laser. However, the spherical component, especially in regards to high degree myopia, is difficult to correct with this technique. Some surgeons combine the use of intracorneal segments with phakic lenses to achieve better UDVA.3 However, if the segments are implanted superficially or when the segments are near to the incision, they can extrude through the anterior corneal surface. In central keratoconus without leukoma or Vogt’s striae, 355° intracorneal segments may be indicated (Keraring, Mediphacos).4 However, in our experience, they remain near to the incision and extrude with greater frequency. For this reason, we reduced the arc to 340°. We do not have enough experience with these shorter segments to make a definitive comment. More than 50years ago, Professor José Ignacio Barraquer demonstrated the law of thickness. Based on this law, there exist two alternatives for flattening the central cornea and correcting myopia, or in this case keratoconus. The first alternative is to augment the peripheral corneal thickness, as the intracorneal segments or lenticule inclusions do in the periphery of the bag created with the femtosecond laser.5 The second alternative is to take out the tissue in the center of the cornea to flatten it.6 Combining the surface ablation with excimer laser (PRK), simultaneously guided by topography and CXL, is called the Athens Protocol. In a very select group of patients, positive results are being reported with keratoconus grade I or II with minor stable refraction at 6 D of spherical equivalent and pachymetry at 400 microns.7 Enrique Graue et al. in Mexico City describe the combination of SMILE and CXL as the “Aztec Protocol” to differentiate it from the Athens Protocol in which SMILE and CXL are combined to treat thwarted ker
圆锥角膜是一种多因素的角膜变性。它通常表现为角膜变薄、不规则散光和视力差,戴眼镜通常无法改善,通常需要使用隐形眼镜。在发展中国家,它是全层角膜移植的主要适应症之一,常见于儿科患者、青少年和年轻人,很少出现在年龄大于35.1岁的个体中。在这些国家,通常很难获得角膜组织,导致角膜移植的等待名单很长。幸运的是,由于疾病的早期发现和新的治疗选择,圆锥角膜穿透性角膜移植术的数量近年来有所减少。上世纪90年代末,西奥·塞勒教授在德国德累斯顿工业大学发现了角膜胶原交联(CXL)。美国食品和药物管理局已经批准了它。多见于有进展性圆锥角膜的年轻患者,CXL的主要目的是避免进展尤其是在飞秒激光的辅助下,角膜内节段可以非常有效地矫正角膜和改善散光成分。然而,球面成分,特别是在高度近视方面,很难用这种技术来纠正。一些外科医生将角膜内节段与晶状体结合使用,以获得更好的udva。3但是,如果节段植入较浅,或者当节段靠近切口时,会从角膜前表面挤出。在没有白血病或Vogt氏纹的中央圆锥角膜中,可以显示355°的角膜内节段(Keraring, Mediphacos)然而,根据我们的经验,它们仍然靠近切口并以更大的频率挤压。因此,我们把弧度减小到340°。对于这些较短的片段,我们没有足够的经验来作出明确的评论。50多年前,约瑟夫·伊格纳西奥·巴拉克教授证明了厚度定律。根据这一规律,有两种选择,即平坦中央角膜和矫正近视,或在本例中矫正圆锥角膜。第一种选择是增加角膜周围的厚度,就像飞秒激光在眼袋周围形成的角膜内段或透镜包涵体一样第二种方法是取出角膜中心的组织使其变平结合准分子激光(PRK)的表面烧蚀,同时引导的地形和CXL,被称为雅典协议。在一组非常精选的患者中,报告了I级或II级圆锥角膜的阳性结果,其轻微的稳定屈光度为6度的球面等效和400微米的视厚墨西哥城的Enrique Graue等人将SMILE和CXL的组合描述为“阿兹特克方案”,以区别于雅典方案。在雅典方案中,SMILE和CXL联合治疗圆锥角膜受损或不规则角膜,在SMILE晶状体取出后向袋内注射核黄素,并使用波长为370nm的紫外线A光照射30分钟,3mW/cm2。他们的研究结果表明,SMILE联合角膜基质内CXL对于常规激光屈光手术禁忌的患者是一种很有希望的治疗选择有多例进展性圆锥角膜患者在没有CXL的情况下接受SMILE治疗,这不是一个可行的选择。9,10其中一些建议的技术仍在研究中,不适合晚期圆锥角膜患者。jos伊格纳西奥·巴拉克医生(Dr. jos Ignacio Barraquer)描述的半月角膜切除术或“新月形角膜切除术”多年来一直用于改善透明边缘变性患者的高度散光或术后高度散光的角膜移植目前,这项技术只能手动执行。其结果不能重复,取决于外科医生的能力和经验。最近,卡里亚佐博士发表了用激光进行半月和环形切除术的发明。他继续了Barraquer博士的工作,但使用准分子激光代替,对圆锥角膜患者进行了更精确的半月形或环形切除术。他使用了为此目的而设计的面具,在面具上进行激光消融。他发表了他的很有希望的结果
{"title":"Annular keratectomy assisted by femto second laser: a case report","authors":"C. Orlich","doi":"10.15406/aovs.2018.08.00314","DOIUrl":"https://doi.org/10.15406/aovs.2018.08.00314","url":null,"abstract":"keratoconus is a multifactorial corneal degeneration. It commonly presents with corneal thinning, irregular astigmatism and poor vision that generally does not improve with glasses and typically requires the use of contact lenses. It appears in pediatric patients, adolescents and young adults and very rarely presents itself in individuals older than 35.1 In developing countries, it is one of the principal indications for a full thickness corneal graft. In these countries, it is generally difficult to obtain tissue, generating long waiting lists for corneal transplants. Fortunately, the number of penetrating keratoplasties for keratoconus has decreased in recent years thanks to earlier detection of the disease and new treatment options. Professor Theo Seiler discovered corneal collagen cross-linking (CXL) at the end of the 1990’s at Dresden Technical University in Germany. The FDA has approved it in the US. It is indicated most in young patients with evidence of progressive keratoconus, the principal purpose of CXL is to avoid progression.2 The intracorneal segments may be very effective in regularizing the cornea and improving the astigmatic component, especially when assisted by the femtosecond laser. However, the spherical component, especially in regards to high degree myopia, is difficult to correct with this technique. Some surgeons combine the use of intracorneal segments with phakic lenses to achieve better UDVA.3 However, if the segments are implanted superficially or when the segments are near to the incision, they can extrude through the anterior corneal surface. In central keratoconus without leukoma or Vogt’s striae, 355° intracorneal segments may be indicated (Keraring, Mediphacos).4 However, in our experience, they remain near to the incision and extrude with greater frequency. For this reason, we reduced the arc to 340°. We do not have enough experience with these shorter segments to make a definitive comment. More than 50years ago, Professor José Ignacio Barraquer demonstrated the law of thickness. Based on this law, there exist two alternatives for flattening the central cornea and correcting myopia, or in this case keratoconus. The first alternative is to augment the peripheral corneal thickness, as the intracorneal segments or lenticule inclusions do in the periphery of the bag created with the femtosecond laser.5 The second alternative is to take out the tissue in the center of the cornea to flatten it.6 Combining the surface ablation with excimer laser (PRK), simultaneously guided by topography and CXL, is called the Athens Protocol. In a very select group of patients, positive results are being reported with keratoconus grade I or II with minor stable refraction at 6 D of spherical equivalent and pachymetry at 400 microns.7 Enrique Graue et al. in Mexico City describe the combination of SMILE and CXL as the “Aztec Protocol” to differentiate it from the Athens Protocol in which SMILE and CXL are combined to treat thwarted ker","PeriodicalId":90420,"journal":{"name":"Advances in ophthalmology & visual system","volume":"79 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74577230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A right eye exophthalmia revealing an en-plaque meningioma in spheno-orbital plate: a case report 右眼突出症显示蝶眶板内斑状脑膜瘤1例
Pub Date : 2018-08-09 DOI: 10.15406/aovs.2018.08.00313
W. Akioud, Taoufik Alabdellaoui
Mrs F. a 39 years old patient with a medical history of hypertension treated with beta blocker and of a type 2 diabetes treated with oral medication. She is referred to our department for chronic headaches, sight impairment, and a right eye proptosis evolving for a year and worsening over time without diplopia. The ocular examination of the right eye shows a visual acuity at 8/10 as well as a proptosis that is scaled grade I, axile, painful, non pulsatile and non reductible without any eye movement limitation. The right cornea suffered an exposure keratitis and the intraocular pressure was normal in both eyes (Figure 1). The right eye fund us showed no abnormalities; neither an optic nerve compression nor any choroid folds. A complete neurological examination was performed on the patient which was completely normal. The MRI scan shows a spheno orbital meningeal tumor highly in favor of an En plaque meningioma (Figure 2).The patient was admitted in the Neurosurgical department where she is to undergo a surgical resection followed by a spheno orbital reconstruction after getting the biopsy results. Figure 1 Right eye proptosis.
f女士,39岁,有高血压病史,用受体阻滞剂治疗,2型糖尿病患者,口服药物治疗。她因慢性头痛、视力障碍和右眼突出而转介至我科,病程持续一年并逐渐恶化,但无复视。右眼视力检查显示视力8/10,眼球突出呈鳞片状I级,轴状,疼痛,无搏动,不复位,无眼动限制。右眼角膜暴露性角膜炎,双眼眼压正常(图1)。右眼眼底未见异常;既没有视神经压迫也没有脉络膜褶皱。对病人进行了全面的神经学检查,结果完全正常。MRI扫描显示蝶眶脑膜瘤高度倾向于En斑块脑膜瘤(图2)。患者住进神经外科,在获得活检结果后接受手术切除和蝶眶重建。图1右眼突出。
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引用次数: 0
Screening for glaucoma suspects in a sample of Egyptian population coming for general checkup 对前来接受普通体检的埃及人群样本进行青光眼疑似筛查
Pub Date : 2018-08-09 DOI: 10.15406/AOVS.2018.08.00312
Iman M Eissa
disease should be implemented in healthcare systems of populations with risk factors for glaucoma.1 POAG is characterized by glaucomatous optic nerve damage and visual field loss in the presence of an open anterior chamber angle. The disease usually has an adult onset, is usually bilateral, and has no specific symptoms except late when patients start losing their central vision.3 Recently, along with the clinical disc signs of glaucoma, Optical coherence tomography (OCT) imaging of the optic nerve head (retinal nerve fiber layer thickness and ganglion cell complex parameters) as well as central corneal thickness have been introduced as factors which can support or defer our diagnosis of glaucoma.4 A disc with a wide cup to disc ratio but normal retinal nerve fiber layer (RNFL) parameters on OCT is unlikely to be glaucomatous. A patient with a relatively thick cornea may give a false high intraocular pressure (Goldmann) reading, and thus is unlikely to be a suspect. The issue of who to consider a glaucoma suspect and which patient requires follow up is thus of crucial clinical importance. This article reports the results of a study done to screen for glaucoma suspects within a sample population of Egyptians at initial eye screening.
应在具有青光眼危险因素人群的卫生保健系统中实施该疾病POAG的特点是青光眼视神经损伤和视野丧失,存在开放的前房角。本病通常为成人发病,通常为双侧发病,除晚期患者开始丧失中央视力外,无特异性症状近年来,随着青光眼的临床椎间盘征象,光学相干断层扫描(OCT)视神经头成像(视网膜神经纤维层厚度和神经节细胞复合体参数)以及角膜中央厚度被引入作为支持或推迟青光眼诊断的因素如果椎间盘杯盘比宽,但OCT上视网膜神经纤维层参数正常,则不太可能是青光眼。角膜相对较厚的患者可能会出现假的高眼压(Goldmann)读数,因此不太可能是可疑的。因此,谁来考虑青光眼的嫌疑以及哪些患者需要随访的问题具有至关重要的临床意义。这篇文章报告了一项研究的结果,在埃及人的样本人群中筛选青光眼嫌疑人在最初的眼睛筛查。
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引用次数: 2
Swept-source-optical coherence tomography study of choroidal thickness in maculopathy type two diabetes mellitus patients 黄斑病变2型糖尿病患者脉络膜厚度的扫描源光学相干断层扫描研究
Pub Date : 2018-08-07 DOI: 10.15406/aovs.2018.08.00311
Osama M. Elbassiouny, Ali Khalil Awadallah, Moataz A. Sallam, F. Soliman
Our study was performed between April 2017 and September 2017, at out-patients clinic (OPD) of Ophthalmic Department, Faculty of Medicine, Suez Canal University Hospital, Ismailia, Egypt. Fifty cases were included in this study. A diabetic group 25 cases (Ischemic & non Ischemic Maculopathy) with or/without macular edema. Detection was performed by Fluorescein Angiography (ZeissVisucam 500), Figure 1. Choroidal Thickness CT was evaluated by SS OCT, Figure 2. It provides sectoral analysis and follow-up of retinal pathologies involving the choroid. All SS-OCT examinations were performed between 12 pm and 2 pm to avoid any inclusion of diurnal variations in CT.3 The macular 3D scan (512X256 A scans/ 0.8 Sec), program of the built-in software was used for our measurements of retinal & Choroidal Thickness. Choroidal Thickness measurement included nine zones. Subfoveal (from the epithelium/Bruch’s membrane complex to the sclerochoroidal interface within 6mm) was measured using automatic analysis software. We analyzed for each of the eyes 9 regions of the macular zone in accordance with Early Treatment Diabetic Retinopathy Study (ETDRS). Figure 3 Control group included 25 healthy adult individuals. Figure 4 shows details of retina and choroid as seen by SS-OCT. Figure 1 Fluorescein Angiography Zeiss-Visucam 500.
我们的研究于2017年4月至2017年9月在埃及伊斯梅利亚苏伊士运河大学医院医学院眼科门诊(OPD)进行。本研究纳入了50例病例。糖尿病组25例(缺血性和非缺血性黄斑病变)伴或不伴黄斑水肿。荧光素血管造影(ZeissVisucam 500)检测,图1。采用SS OCT评估脉络膜厚度,见图2。它提供涉及脉络膜的视网膜病理的部门分析和随访。所有SS-OCT检查均在下午12点至下午2点之间进行,以避免任何包括ct的日变化。3黄斑3D扫描(512X256 A扫描/ 0.8秒),内置软件程序用于测量视网膜和脉络膜厚度。脉络膜厚度测量包括9个区域。使用自动分析软件测量中央凹下(从上皮/布鲁氏膜复合体到硬脉络膜界面6mm内)。我们根据早期治疗糖尿病视网膜病变研究(ETDRS)对每只眼睛的黄斑区9个区域进行了分析。图3对照组25例健康成人。图4为SS-OCT所见视网膜和脉络膜的细节。图1蔡司visucam 500荧光素血管造影。
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引用次数: 1
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Advances in ophthalmology & visual system
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