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The Introduction of Some Mushrooms as an Effective Source of Medicines in Iran Northern 在伊朗北部引进一些蘑菇作为有效的药物来源
Pub Date : 2018-01-01 DOI: 10.4172/0974-8369.1000451
E. Alinia-Ahandani, M. Fazilati, Zahra Alizadeh, A. Boghozian
Northern parts of the Iran, including Guilan and Mazandaran, are known as the best Hyrcanian forest place in the world. Most of these lands are rolling or hilly topography. There are several types of edible or medicinal mushrooms that either grows on wood (i.e., logs) or on the forest floor. My extension program in Guilan focuses on the production of shiitake (Lentinula edodes L.) mushrooms because they are becoming the best known of the exotic mushrooms, but there are several others to consider as source of medicines. In this research we overlooked mushrooms as medicinal gadgets and reviewed some varieties like Lentinula edodes L, Grifola frondosa L., Agaricus spp. L., Pleurotus spp., Morchella spp. L., Stropharia rugosa-annulata L,. Hericium spp. L., Ganoderma lucidum L. and etc. Finally we introduced some remarkable overview on some highlighted ones with point of their importance.
伊朗北部地区,包括吉兰和马赞达兰,被认为是世界上最好的海卡尼亚森林。这些土地大多是起伏的或丘陵地形。有几种可食用或药用蘑菇,它们要么生长在木头上(即原木),要么生长在森林地面上。我在桂兰的扩展项目侧重于香菇(Lentinula edodes L.)的生产,因为它们正在成为最知名的外来蘑菇,但还有其他几种可以作为药物来源。本文综述了香菇(Lentinula edodes L.)、灰树花(Grifola frondosa L.)、松茸菇(Agaricus spp. L.)、侧耳菇(Pleurotus spp. L.)、羊肚菌(Morchella spp. L.)、环孢蘑菇(Stropharia rugosa-annulata L.)等药用蘑菇品种。猴头菌、灵芝等。最后,我们介绍了一些值得注意的概述,其中一些突出的重要性点。
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引用次数: 16
Combination of Osteogenesis imperfecta, Ehlers Danlos syndrome, TRAPsyndrome, and Stickler syndrome as multiple inherited connective tissue disordersin a 28-year-old Egyptian woman. 成骨不全、Ehlers Danlos综合征、trap综合征和Stickler综合征合并为一名28岁的埃及女性的多重遗传性结缔组织疾病。
Pub Date : 2018-01-01 DOI: 10.35841/biology-medicine.2.2.9-11
Hany El-Saadany, S. Negm
Collagen related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis assembly posttranslational modification a secretion or other processes involved in normal collagen production. One thousand mutations have been identified in twelve out of more than twenty types of collagen. These mutations can lead to various diseases at the tissue level. This report describes an Egyptian female presented by multiple different polysystematic disorders proved to be manifestations of multiple rare inherited connective tissue disorders in the same patient to be the first woman worldwide to comprise all these rare syndromes up to our review.
胶原蛋白相关疾病最常见的原因是遗传缺陷或营养缺乏,影响了生物合成组装、翻译后修饰、分泌或正常胶原蛋白产生的其他过程。在20多种胶原蛋白中,有12种已经发现了1000个突变。这些突变可以在组织水平上导致各种疾病。本报告描述了一名埃及女性,其表现为多种不同的多系统疾病,经证实为同一患者的多种罕见遗传性结缔组织疾病的表现,是世界上第一个包括所有这些罕见综合征的女性。
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引用次数: 1
Prevalence of Postural Dysfunction among Female College Students-A Qualitative Analysis 女大学生体位功能障碍患病率的定性分析
Pub Date : 2018-01-01 DOI: 10.4172/0974-8369.1000421
S. Kiruthika, K. Rekha, G. Preethy, M. Abraham
In the present day, proper posture is considered to be a state of musculoskeletal balance involving minimal body stress or strain. Modern life and the rise in a sedentary lifestyle have had a negative effect on most of the human motor behavior. This study included 804 female subjects, who were photographed in the sagittal and frontal planes. The common postural misalignments analyzed were swayback, lumbar lordosis, thoracic kyphosis, forward head, rounded shoulder, and pronated foot. The results showed that older women had greater incidence of forward head, thoracic kyphosis, and pronated foot. The abnormalities were probably related to prolonged sitting and reduced fl exibility
在当今,正确的姿势被认为是一种肌肉骨骼平衡的状态,涉及最小的身体压力或紧张。现代生活和久坐生活方式的增加对大多数人类运动行为产生了负面影响。这项研究包括804名女性受试者,他们在矢状面和额叶面拍照。常见的体位失调包括腰背偏倚、腰椎前凸、胸后凸、头向前、肩圆和足内翻。结果显示,老年妇女有较高的发病率前头,胸后凸和足内翻。这些异常可能与久坐和灵活性降低有关
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引用次数: 4
Correlation of CT Findings and Clinical Characteristics of Pneumocystis Pneumonia in Patients with Acquired Immunodeficiency Syndrome 获得性免疫缺陷综合征肺囊虫性肺炎的CT表现与临床特征的相关性研究
Pub Date : 2018-01-01 DOI: 10.4172/0974-8369.1000447
M. Kawakami, M. Tominaga, C. Yano, M. Okamoto, Masayuki Nakamura, Y. Sakazaki, Y. Naito, T. Kawayama, T. Hoshino
Background: Pneumocystis pneumonia (PCP) is the most common opportunistic infection, and it is difficult to diagnose as PCP. The aim of this study was to assess whether CT findings or clinical characteristics contribute to early diagnosis of PCP. Method: Twenty-six patients with AIDS and PCP received medical treatment at the Kurume University Hospital between 1999 and 2018. None of the patients with AIDS had been diagnosed as HIV positive until the episode of PCP. In this study, the correlation between computed tomography (CT) findings and clinical characteristics were analyzed in patients with AIDS and PCP. The number of patients with PCP is not that high in Japan; therefore, it is difficult to diagnose patients with PCP in the clinic. Results: This study included 24 men and 2 women, and the mean age was 47.8 years. The mean CD4 cell count was 65.7 cells/μl, HIV-viral load was 680 × 104 copy, β-D-glucan (βDG) level was 234 pg/ml, and mean time till diagnosis was 41.3 days; 14 patients had hypoxemia. Twelve patients had PCP, 10 had cytomegalovirus (CMV) infection, 2 had Cryptococcus infection, 1 had Entamoeba histolytica infection, 1 had non-tuberculous mycobacteria infection, and 1 had Toxoplasma infection. CT images of the patients showed 10 cases with ground-glass opacity (GGO), 13 with consolidation, 1 with small nodules, 2 with a cavity, and 1 with cyst formation. Nine cases revealed peripheral distribution with peripheral sparing, 1 had pleural fluid, and 6 had lymph node enlargement. The mean time till diagnosis and cough were significantly correlated with lymphadenopathy. Patients with consolidation were more likely to be infected with CMV. Conclusion: GGO, combined with peripheral distribution and peripheral sparing, was the most common CT finding. When consolidation was present in PCP patients as shown in CT images, the patients were more likely to be infected with CMV.
背景:肺囊虫性肺炎(PCP)是最常见的机会性感染,诊断困难。本研究的目的是评估CT表现或临床特征是否有助于PCP的早期诊断。方法:1999年至2018年在库鲁姆大学医院接受治疗的26例艾滋病合并PCP患者。在PCP发作之前,没有一个艾滋病患者被诊断为HIV阳性。本研究分析AIDS合并PCP患者的CT表现与临床特征的相关性。在日本,PCP患者的数量并没有那么高;因此,临床上对PCP患者的诊断比较困难。结果:男性24例,女性2例,平均年龄47.8岁。平均CD4细胞计数65.7个/μl, hiv病毒载量680 × 104拷贝,β- d -葡聚糖(βDG)水平234 pg/ml,平均诊断时间41.3 d;14例出现低氧血症。PCP 12例,巨细胞病毒感染10例,隐球菌感染2例,溶组织内阿米巴感染1例,非结核分枝杆菌感染1例,弓形虫感染1例。CT表现为磨玻璃影(GGO) 10例,实变13例,小结节1例,空腔2例,囊肿形成1例。9例外周分布伴外周保留,1例胸腔积液,6例淋巴结肿大。平均诊断时间和咳嗽与淋巴结病变有显著相关性。合并合并的患者更容易感染巨细胞病毒。结论:GGO伴外周分布和外周保留是最常见的CT表现。当CT图像显示PCP患者出现实变时,患者更有可能感染巨细胞病毒。
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引用次数: 0
Evaluation of the anxiolytic activity of the leaves of Nymphaea lotus (WaterLily) in mice. 睡莲叶对小鼠抗焦虑活性的评价。
Pub Date : 2018-01-01 DOI: 10.35841/BIOLOGY-MEDICINE.2.1.21-24
W. Aduema, C. Akunneh-Wariso, Amah Ak, Vidona Wb
The anxiolytic effect of the leaves of water lily was investigated using mice as experimental animals. Thirty (30) were mice randomly divided into group 1, 2 and 3. Before the neurobehavioral parameters were assessed, the LD50 and the phytochemical screening of the leaves of the plant were determined. The open field maze and the transition box apparatus were used to determine the level of fear and anxiety related behaviors in mice. In the open field arena, the grooming frequency was statistically not different when compared to control. Stretch attend posture frequency (SAP) was statistically higher in the test groups when compared to control (P<0.001). It was also observed that the frequency of defecation decreased in the treated groups when compared to the control group (P<0.01). The light duration box and frequency of transition were statistically higher (P<0.001) compared to control. Thus, the leaves of the plant tend to reduce the level anxiety in mice.
以小鼠为实验动物,研究了睡莲叶的抗焦虑作用。30只小鼠随机分为1、2、3组。在评估神经行为参数之前,确定了植物叶片的LD50和植物化学筛选。采用开阔地迷宫和过渡箱仪测定小鼠恐惧焦虑相关行为水平。在开放场地竞技场,梳理频率与对照组相比没有统计学差异。与对照组相比,实验组的伸展姿势频率(SAP)在统计学上更高(P<0.001)。与对照组相比,治疗组排便次数明显减少(P<0.01)。与对照组相比,光持续时间盒和转换频率具有统计学意义(P<0.001)。因此,这种植物的叶子倾向于降低老鼠的焦虑水平。
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引用次数: 5
Glycine powder therapy on a hairy tongue: A case report. 甘氨酸粉治疗舌毛1例。
Pub Date : 2018-01-01 DOI: 10.35841/biology-medicine.2.2.5-6
C. Casu, L. Viganó
Black hairy tongue (BHT) is a benign condition characterized by a discolored, hairy appearance of the dorsal tongue. The lesion is distributed on the dorsal aspect of the tongue and does not involve the lateral and the tip site of the tongue. The most common discoloration of the tongue in this condition is black to blackish-brown, but it can present with green or yellow discoloration or can lack pigmentation altogether. Glycin powder is described in the literature for the treatment of periodontitis and per implantitis, but never is it used for treatment of hairy tongue. 50-year-old male patient came to our observation showed a whitish film on the tongue with hypertrophy of the filiform papillae, typical of a hairy tongue. It is decided to treat the patient with glycine powder using an airflow hand piece. The powder was insufflated for about 2 minutes on the lingual central surface. 7 days after the lingual lesion healed. The use of glycin powder is considered safe and effective in the literature, especially in removing biofilms. This case report could be the starting point for randomized clinical trials that investigate the use of glycine powder in treatment of hairy tongue.
黑毛舌(BHT)是一种良性疾病,其特征是舌背变色,多毛。病变分布于舌背侧,不累及舌侧和舌尖。在这种情况下,舌头最常见的变色是黑色到黑棕色,但也可能出现绿色或黄色变色,或者完全没有色素沉着。甘氨酸粉在文献中被描述用于治疗牙周炎和种植体炎,但从未用于治疗舌毛。50岁男性患者到我们就诊时,舌上有一白色膜伴丝状乳头肥大,为典型的多毛舌。决定用甘氨酸粉治疗患者,并使用气流手片。在舌中央表面喷气约2分钟。舌损愈合后7天。在文献中,甘氨酸粉的使用被认为是安全有效的,特别是在去除生物膜方面。本病例报告可作为研究甘氨酸粉治疗舌毛的随机临床试验的起点。
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引用次数: 0
Cytotoxic Effect of Selected Wild Medicinal Plant Species from Jordan on Two Different Breast Cancer Cell Lines, MCF7 and T47D 约旦部分野生药用植物对两种不同乳腺癌细胞株MCF7和T47D的细胞毒作用
Pub Date : 2018-01-01 DOI: 10.4172/0974-8369.1000443
Israa Yousef, Sawan Oran, Y. Bustanji, D. Al-Eisawi, B. Abu-irmaileh
Background: Breast cancer is the most common type of cancer in females in Jordan, it accounts for about 35.3% of all female cancers. Searching for alternative medicine from plants for breast cancer is a paramount importance. No studies have investigated the cytotoxic effect of the plants of Ajuga chia, Micromeria nervosa and Origanum dayi that are belonging to the family Lamiaceae and are growing wild in Jordan.Objective: To investigate the cytotoxic effect of the A. chia, M. nervosa and O. dayi plant species against two different breast cancer cell lines MCF7 and T47D.Materials and methods: The aerial parts of the aforementioned plant species were extracted with water and ethanol. Cell viability was assessed using MTT assay, after incubation with various concentrations of plant extracts.Results: A pronounced cytotoxic effect of the ethanolic extract of O. dayi against MCF7 and T47D cell lines, with IC50=99.4 ± 2.9 and 250 ± 4 μg/mL respectively. The ethanolic extract of A. chia has shown cytotoxic effect against T47D cell line with IC50=200 ± 5.2. The aqueous and ethanolic extracts of M. nervosa did not show any toxicity against the aforementioned cell lines. The three plant species showed selectivity when they were tested on fibroblasts (normal cells).Conclusion: Origanum dayi exhibited good cytotoxicity against aforementioned cell lines among the detected plant species, so O. dayi is considered a candidate for the development of a novel agent against breast cancer.
背景:乳腺癌是约旦女性中最常见的癌症类型,约占所有女性癌症的35.3%。从植物中寻找治疗乳腺癌的替代药物是至关重要的。在约旦野生生长的牛膝科植物牛膝草(Ajuga chia)、神经小细穗草(Micromeria nervosa)和大牛膝草(Origanum dayi)的细胞毒作用还没有研究。目的:探讨黄芪、黄芪和黄芪对两种乳腺癌细胞株MCF7和T47D的细胞毒作用。材料与方法:用水和乙醇提取上述植物的地上部分。用不同浓度的植物提取物孵育后,用MTT法评估细胞活力。结果:大黄醇提物对MCF7和T47D细胞有明显的细胞毒作用,IC50分别为99.4±2.9和250±4 μg/mL。枳椇醇提物对T47D细胞株具有细胞毒作用,IC50=200±5.2。水提液和醇提液对上述细胞系均无毒性作用。这三种植物在成纤维细胞(正常细胞)上测试时显示出选择性。结论:在检测到的植物种类中,大牛对上述细胞系具有良好的细胞毒性,因此大牛可能是开发抗乳腺癌新药的候选药物。
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引用次数: 7
Formation of Neutrophil Extracellular Traps against Infection and During Inflammation: Boon or a Bane? 抗感染和炎症期间中性粒细胞胞外陷阱的形成:是福还是祸?
Pub Date : 2018-01-01 DOI: 10.4172/0974-8369.1000446
S. Alasmari
Neutrophils are the first line of innate immune defence against pathogens. They have three different processes for directly attacking microorganisms, including phagocytosis, degranulation, and forming neutrophil extracellular traps (NETs). The methods of degranulation and phagocytosis are well established. However, several recent studies have been conducted to understand the potential role of NETs in diseases. The involvement of NETs was shown in several conditions including infections and inflammation. This review will discuss the morphology and mechanisms of NET formation, as well as NET formation against infection and during inflammation.
中性粒细胞是先天免疫防御病原体的第一道防线。它们有三种不同的直接攻击微生物的过程,包括吞噬、脱颗粒和形成中性粒细胞胞外陷阱(NETs)。脱肉芽和吞噬的方法已经建立。然而,最近进行了几项研究,以了解NETs在疾病中的潜在作用。包括感染和炎症在内的几种情况都显示了NETs的作用。本文将讨论NET的形态和形成机制,以及NET在抗感染和炎症过程中的形成。
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引用次数: 0
A case series of over-hydration in making baby formula -Importance of the metricsystem. 制作婴儿配方奶粉过程中过量补水的一系列案例——公制的重要性。
Pub Date : 2018-01-01 DOI: 10.35841/BIOLOGY-MEDICINE.2.1.25-28
Okpodu Cm, Pyuzza So
Over-hydration is a serious concern when making formula for infants. If the formula is not made according to the instructions because the wrong amount of formula is used in relationship to the volume of water added, the infant could experience life threatening changes. Understanding the difference between US fluid ounces (US fl oz) and UK fluid ounces (UK fl oz) was the objective of this case. Baby formula and breast feeding have been a topic of discussion in the media. Based on this case we able to promote dialogue and critical analysis of the risk and benefits of formula feeding as compared to breastfeeding.
在制作婴儿配方奶粉时,过度补水是一个严重的问题。如果由于配方奶粉的用量与添加的水的量的关系不对,而没有按照说明制作配方奶粉,婴儿可能会经历危及生命的变化。了解美国液盎司(US fl oz)和英国液盎司(UK fl oz)之间的区别是本案例的目的。婴儿配方奶粉和母乳喂养一直是媒体讨论的话题。基于这一案例,我们能够促进对话和对配方奶喂养与母乳喂养相比的风险和益处的批判性分析。
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引用次数: 1
X-linked colour vision deficiency (CVD) in some government school childrenof Nepal. 尼泊尔部分公立学校儿童的x连锁色觉缺陷(CVD)。
Pub Date : 2018-01-01 DOI: 10.35841/biology-medicine.2.1.12-14
K. Sushil, D. Sushma, G. Rani
The X-linked colour vision deficiencies have different frequency and incidence in various locations and different castes. A total of 386 Nepalese children including 214 males and 172 females between ages 10-16 years were evaluated and screened for X-linked CVD in different government schools. An individual child was presented with the Ishihara’s 38 Plates edition under normal day light from a distance of 75 cm and single plate was shown to them for 5 seconds. Among 214 boys, 13 (6.07%) were colour deficient. Among 172 girls, 4(2.32%) were colour deficient. The prevalence of colour vision deficiency in school children shows the importance of proper screening in schools.
x连锁色觉缺陷在不同的地区和不同的种姓有不同的频率和发病率。共有386名尼泊尔儿童,其中包括214名男性和172名女性,年龄在10-16岁之间,在不同的政府学校接受了x连锁心血管疾病的评估和筛查。在正常的日光下,在75厘米的距离外,给一个孩子看石原的38版,其中一个盘子给他们看5秒钟。214名男孩中有13名(6.07%)色盲。在172名女孩中,有4名(2.32%)色盲。学童普遍存在色觉缺陷,可见在学校进行适当筛检的重要性。
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引用次数: 0
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Biology and medicine (Aligarh)
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