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Pregnancy and the Tropics: Physiology, Environment and Infectious Disease 怀孕和热带:生理、环境和传染病
Pub Date : 2014-05-29 DOI: 10.4172/2329-9088.1000173
I. Carroll
Disease processes often present and progress differently during pregnancy, often with worsening of the disease itself or adverse effects on the pregnancy. This article presents a brief overview of the physiological changes that occur with pregnancy and how they affect the pregnant patient’s response to the natural environment and to infectious diseases.
在怀孕期间,疾病的表现和进展往往不同,往往伴有疾病本身的恶化或对妊娠的不利影响。本文简要介绍了妊娠期间发生的生理变化,以及这些变化如何影响孕妇对自然环境和传染病的反应。
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引用次数: 0
Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women 人类t细胞淋巴病毒1型的垂直传播:咨询血清阳性妇女的影响
Pub Date : 2014-05-19 DOI: 10.4172/2329-9088.1000172
M. S. Amaranto-Damasio, C. F. Leal-Horiguchi, G. Seabra-Freitas, Bastos Rhc, Reiss Db, Couto Brgm, M. Ml, Starling Alb, Dias As, Namen-Lopes Mss, Carneiro-Proietti Abf
Objective: Although HTLV-1 is associated with severe diseases, there is ongoing vertical transmission since prenatal HTLV screening is not implemented in countries where the virus is present. We performed a cross-sectional analysis to verify the impact of counseling pregnant HTLV-1 seropositive women, who participate in the GIPH cohort study in Brazil, on this vertical transmission. Methods: GIPH study started in 1997 as an open prevalent cohort of HTLV-positive individuals. Children born from HTLV-1 seropositive women were divided into: (1) born before and (2) after the participation of mothers in the GIPH cohort (“GIPH babies”). The pregnant women participating in the study were counseled in order to prevent viral transmission, with recommendations of avoiding breastfeeding, giving infant formula, and preferably having the delivery by cesarean section. Results: We identified 54 children born of HTLV seropositive mothers. 3/21 (14.3%) of the children born from mothers who received no counseling were found positive for HTLV-1, in contrast to 1/18 (5.6%) of the “GIPH babies”, whose mothers received counseling. 15 children were not tested, either due to the family’s refusal or impossibility to locate them. Discussion: We found that it was worthwhile to counsel the mothers, since, as previously reported in the literature, we could observe a decline in the vertical transmission, which demonstrates the importance of prenatal screening of the virus. These actions should be widespread in countries where HTLV is present, in order to avoid the silent transmission of HTLV and future diseases in children born from positive mothers.
目的:尽管HTLV-1与严重疾病相关,但由于在病毒存在的国家未实施产前HTLV筛查,因此存在持续的垂直传播。我们进行了一项横断面分析,以验证对参与巴西GIPH队列研究的HTLV-1血清阳性孕妇进行咨询对这种垂直传播的影响。方法:GIPH研究开始于1997年,作为htlv阳性个体的公开流行队列。HTLV-1血清阳性妇女所生的孩子分为:(1)在母亲参与GIPH队列之前出生的和(2)在母亲参与GIPH队列之后出生的(“GIPH婴儿”)。参与研究的孕妇被告知要防止病毒传播,建议避免母乳喂养,给婴儿配方奶粉,最好是剖宫产。结果:我们确定了54名HTLV血清阳性母亲所生的儿童。未接受咨询的母亲所生的孩子HTLV-1阳性比例为3/21(14.3%),而接受咨询的母亲所生的“GIPH婴儿”HTLV-1阳性比例为1/18(5.6%)。15名儿童没有接受检测,要么是因为家庭拒绝,要么是因为无法找到他们。讨论:我们发现咨询母亲是值得的,因为正如先前文献报道的那样,我们可以观察到垂直传播的下降,这表明产前筛查病毒的重要性。这些行动应在艾滋病毒存在的国家广泛开展,以避免艾滋病毒无声传播和阳性母亲所生的儿童将来患病。
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引用次数: 1
Risk Factors Associated With Leishmaniasis 与利什曼病相关的危险因素
Pub Date : 2014-04-30 DOI: 10.4172/2329-9088.1000E118
A. Oryan, Soodeh Alidadi, M. Akbari
Received date: April 25, 2014, Accepted date: April 26, 2014, Published date: April 30, 2014Copyright: © 2014 Oryan A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.
收稿日期:2014年4月25日,录用日期:2014年4月26日,发表日期:2014年4月30日版权所有:©2014 Oryan A, et al.。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。
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引用次数: 32
Effect of Methylprednisolone and Cyclophosphamide on the Survival of Patients with Leptospirosis, Renal Failure and Pulmonary Hemorrhage 甲基强的松龙和环磷酰胺对钩端螺旋体病、肾功能衰竭和肺出血患者生存的影响
Pub Date : 2014-04-26 DOI: 10.4172/2329-9088.1000171
Rudi Joy T Manipol-Larano, R. Danguilan, S. Santos, J. Chavez, M. Mendoza
Objectives: To determine the efficacy of three day methylprednisolone plus single dose intravenous cyclophosphamide on the survival of patients with leptospirosis, renal failure and pulmonary hemorrhage. Methods: A retrospective review of 138 patients diagnosed with leptospirosis at the National Kidney and Transplant Institute (NKTI) from August 1, 2009 to August 31, 2013 were included in the study. Patients were grouped according to those who received standard therapy with a 3-day course of Hydrocortisone (HC group) compared to a 3-day course of Methylprednisolone-Cyclophosphamide (MP-C). Patient survival, length of hospital stay and time to becoming dialysis independent were compared. Results: There were 65 patients in the HC group and 73 patients in the MP-C group. Mean age was 35.9 years, with male predominance. The most common clinical manifestation was fever. Thrombocytopenia was the major indication to steroid therapy. Survival of patients given MP-C was significantly higher than those given HC (88% and 74% respectively; p=0.035). The post treatment activated Plasma Thromboplastin Time (aPTT) was significantly lower in the MP-C group. There was no significant difference in the length of hospital stay and time to becoming dialysis independent. Conclusion: Three day MP-C pulsing significantly improves survival of patients with leptospirosis, renal failure and pulmonary hemorrhage.
目的:探讨甲基强的松龙联合单剂量环磷酰胺对钩端螺旋体病、肾功能衰竭和肺出血患者生存期的影响。方法:回顾性分析2009年8月1日至2013年8月31日在美国国家肾脏和移植研究所(NKTI)诊断为钩端螺旋体病的138例患者。患者根据接受3天疗程氢化可的松(HC组)和3天疗程甲基强的松-环磷酰胺(MP-C)的标准治疗分组。比较两组患者的生存时间、住院时间和独立透析时间。结果:HC组65例,MP-C组73例。平均年龄35.9岁,以男性为主。最常见的临床表现为发热。血小板减少症是类固醇治疗的主要适应症。MP-C组患者的生存率显著高于HC组(分别为88%和74%;p = 0.035)。MP-C组治疗后活化血浆凝血活素时间(aPTT)明显降低。两组患者住院时间和独立透析时间无显著差异。结论:3 d MP-C脉冲治疗可显著提高钩端螺旋体病、肾功能衰竭和肺出血患者的生存率。
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引用次数: 5
Malaria Diagnostics, Where are we Now 疟疾诊断,我们现在在哪里
Pub Date : 2014-04-26 DOI: 10.4172/2329-9088.1000169
D. Mayer, Luke Dixon, J. Porter-Kelley
Malaria, a worldwide disease of high morbidity and mortality, causes over 1 million deaths per year, mostlyin children less than 5 years of age [1,2]. Delayed treatment of malaria increases the chances of death and neurological disease [3]. In addition, to bring about malaria eradication and prolong accumulation of drug resistant parasites, treatment must follow an accurate diagnosis. To that end, a major goal in malaria diagnostics is to develop assays that are both sensitive and cost-effective for use in developing countries, which are economically and infrastructurally challenged. This review analyzes the current state of malarial diagnostics, from the gold standard of Giemsa-stained blood smears for microscopic examination to highly sensitive and novel technologies. Here, we suggest a future direction for malarial diagnostics.
疟疾是一种高发病率和高死亡率的世界性疾病,每年造成100多万人死亡,其中大多数是5岁以下儿童[1,2]。疟疾的延迟治疗增加了死亡和神经系统疾病的机会。此外,为了根除疟疾和延长耐药寄生虫的积累,必须在准确诊断之后进行治疗。为此目的,疟疾诊断的一个主要目标是开发既灵敏又具有成本效益的检测方法,以便在经济和基础设施受到挑战的发展中国家使用。这篇综述分析了疟疾诊断的现状,从金标准的吉姆萨染色血涂片显微镜检查到高灵敏度和新颖的技术。在此,我们提出了疟疾诊断的未来方向。
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引用次数: 1
Evasive Mechanisms of Oral Microflora 口腔菌群的规避机制
Pub Date : 2014-04-26 DOI: 10.4172/2329-9088.1000168
S. Chatterjee
Oral microflora is an inherent and essential component in maintaining the oral health status of an individual. It is a necessary evil that can turn pathogenic if the oral microenvironment undergoes imbalance in homeostatic mechanisms. Thus, the oral microbiome is an intricate ecosystem where the host defense mechanisms keep in check the exuberant display of its otherwise foreign colonizers. This article presents with an overview of mechanisms that enable these microorganisms to evade the defense mechanisms in play in oral cavity.
口腔菌群是维持个体口腔健康状态的固有和必要组成部分。如果口腔微环境在稳态机制上发生不平衡,就可能变成致病性,这是一种必然之恶。因此,口腔微生物群是一个复杂的生态系统,宿主的防御机制一直在检查其其他外来殖民者的旺盛表现。本文介绍了使这些微生物逃避口腔防御机制的机制概述。
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引用次数: 3
Attributes of Patients with Suicide Attempts Seen At the Niger Delta University Teaching Hospital within a Year: A Case Series 尼日尔三角洲大学教学医院一年内自杀未遂患者的特征:一个案例系列
Pub Date : 2014-04-25 DOI: 10.4172/2329-9088.1000170
C. Eze, E. Desmond
Suicide is a leading cause of death worldwide. The rates of suicide attempts are on the rise especially in Nigeria and other developing countries. Youths are mostly affected and this presents a potential danger to national economy and well being. Unfortunately, the exact magnitude of these problems in Nigeria is unknown due to scanty literature. This underscores the need for further research. We present 5 case reports of patients with suicide attempts who were managed at the NDUTH within the period of one year. Our aim was to identify factors that are common among these patients and which could be highly associated with their suicidal behaviors. More so, to compare these factors with existing literature and to highlight treatment given and outcomes. Depression, dysfunctional family settings and financial/ relationship difficulties are common associated factors leading to frustration and suicide attempts. There is need for continuous health education and effective primary health care system to improve prevention of suicidal behaviors
自杀是全世界最主要的死亡原因。企图自杀的比率正在上升,尤其是在尼日利亚和其他发展中国家。受影响最大的是年轻人,这对国民经济和福祉构成了潜在的威胁。不幸的是,由于文献匮乏,尼日利亚这些问题的确切程度尚不清楚。这强调了进一步研究的必要性。我们报告了5例自杀未遂患者的病例报告,这些患者在一年内在NDUTH进行了治疗。我们的目的是确定这些患者中常见的因素,这些因素可能与他们的自杀行为高度相关。更重要的是,将这些因素与现有文献进行比较,并强调给予的治疗和结果。抑郁、不正常的家庭环境和经济/关系困难是导致沮丧和自杀企图的常见相关因素。需要持续的健康教育和有效的初级卫生保健系统来改善自杀行为的预防
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引用次数: 4
A Need to Spread Awareness Regarding the Ill Effects of Arecanut and Its Commercial Products on Oral Health 需要宣传槟榔及其商业产品对口腔健康的不良影响
Pub Date : 2014-04-21 DOI: 10.4172/2329-9088.1000167
R. Prabhu, V. Prabhu, L. Chatra
Areca nut, commonly known as betel nut or supari, is a fruit of areca catechu palm tree, which is native of South Asia and Pacific islands. The seed or endosperm is consumed fresh, boiled or after sun drying or curing. Areca nut is chewed by itself or in the form of commercial preparations like pan masala and gutka. Chewing areca nut is thought to have central nervous system stimulating effect and along with this it is known to have salivary stimulating and digestive properties. Along with the beneficial effects of areca nut one of its most harmful effects on the human body in general and oral cavity in particular is the development of potentially malignant disorder called Oral Submucous Fibrosis. The present paper discusses the ill effects of consumption of areca nut and its commercial products on oral health and a need to spread the awareness regarding the same.
槟榔,俗称槟榔或supari,是原产于南亚和太平洋岛屿的槟榔儿茶棕榈树的果实。种子或胚乳是新鲜、煮熟或晒干或腌制后食用的。槟榔可以单独咀嚼,也可以做成商业制剂,比如pan masala和gutka。咀嚼槟榔被认为具有刺激中枢神经系统的作用,此外,它还具有刺激唾液和消化的特性。槟榔果除了有益的作用外,它对人体,尤其是口腔最有害的影响之一是潜在的恶性疾病的发展,称为口腔粘膜下纤维化。本文讨论了食用槟榔及其商业产品对口腔健康的不良影响,以及传播这一意识的必要性。
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引用次数: 4
Prognostic Factors in Severe Falciparum Malaria 严重恶性疟疾的预后因素
Pub Date : 2014-04-20 DOI: 10.4172/2329-9088.1000E117
P. Wilairatana, N. Tangpukdee, S. Krudsood
Polrat Wilairatana1,2*, Noppadon Tangpukdee1,2 and Srivicha Krudsood1,3 1Malaria Clinical Research Unit, Malaria Excellence Center, Mahidol University, Thailand 2Department of Clinical Tropical Medicine, Mahidol University, Thailand 3Department of Tropical Hygiene, Mahidol University, Thailand *Corresponding author: Polrat Wilairatana, Malaria Clinical Research Unit, Malaria Excellence Center and Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University 420/6 Rajvithi Road, Rajthevi, Bangkok 10400, Thailand, Tel: 66-081-8602101; E-mail: polrat.wil@mahidol.ac.th
Polrat Wilairatana1,2*, Noppadon Tangpukdee1,2 and Srivicha Krudsood1,3 1泰国玛希隆大学疟疾卓越中心疟疾临床研究单元2泰国玛希隆大学热带临床医学系3泰国玛希隆大学热带卫生系*通讯作者:Polrat Wilairatana,泰国曼谷10400 Rajthevi Rajvithi路420/6号,Mahidol大学热带医学院疟疾卓越中心和临床热带医学系疟疾临床研究单位,电话:66-081-8602101;电子邮件:polrat.wil@mahidol.ac.th
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引用次数: 2
Vulnerable Wild Animal Species, Conservation and Genetic Investigations 易危野生动物物种,保护和遗传调查
Pub Date : 2014-04-10 DOI: 10.4172/2329-9088.1000E116
M. Giangaspero, Metab Al Ghafri
To date, approximately 5,600 species of animals are protected by the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) against over-exploitation through international trade. Among mammals, 300 species are considered threatened with extinction. Conservation efforts rely on a wide spectrum of measures, from rising public awareness to adapted legal framework. In this context, wild animal conservation centers represent a core aspect. Accurate management is required also through qualified veterinary care and research activities, including genetic investigations to support conservation strategies.
迄今为止,约有5600种动物受到《濒危野生动植物种国际贸易公约》(CITES)的保护,防止通过国际贸易过度开发。在哺乳动物中,有300种被认为面临灭绝的威胁。保护工作依赖于广泛的措施,从提高公众意识到适应的法律框架。在这种背景下,野生动物保护中心代表了一个核心方面。还需要通过合格的兽医护理和研究活动,包括支持保护战略的遗传调查,进行准确的管理。
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引用次数: 0
期刊
Tropical medicine & surgery
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