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Brain Functional Alterations in Patients With Benign Paroxysmal Positional Vertigo Demonstrate the Visual–Vestibular Interaction and Integration 良性阵发性位置性眩晕患者的大脑功能变化显示了视觉与前庭的相互作用和整合。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70053
Jing Wu, Liang Shu, Chen-Yan Zhou, Xiao-Xia Du, Xu-Hong Sun, Hui Pan, Guo-Hong Cui, Jian-Ren Liu, Wei Chen
<div> <section> <h3> Objective</h3> <p>This study aimed to analyze the features of resting-state functional magnetic resonance imaging (rs-fMRI) and clinical relevance in patients with benign paroxysmal positional vertigo (BPPV) that have undergone repositioning maneuvers.</p> </section> <section> <h3> Methods</h3> <p>A total of 38 patients with BPPV who have received repositioning maneuvers and 38 matched healthy controls (HCs) were enrolled in the present study from March 2018 to August 2021. Imaging analysis software was employed for functional image preprocessing and indicator calculation, mainly including the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), percent amplitude of fluctuation (PerAF), and seed-based functional connectivity (FC). Statistical analysis of the various functional indicators in patients with BPPV and HCs was also conducted, and correlation analysis with clinical data was performed.</p> </section> <section> <h3> Results</h3> <p>Patients with BPPV displayed decrease in ALFF, fALFF, and PerAF values, mainly in the bilateral occipital lobes in comparison with HCs. Additionally, their ALFF and fALFF values in the proximal vermis region of the cerebellum increased relative to HCs. The PerAF values in the bilateral paracentral lobules, the right supplementary motor area (SMA), and the left precuneus decreased in patients with BPPV and were negatively correlated with dizziness visual analog scale (VAS) scores 1 week after repositioning (W1). In addition, in the left fusiform gyrus and lingual gyrus, the PerAF values show a negative correlation with dizziness handicap inventory (DHI) scores at initial visit (W0). Seed-based FC analysis using the seeds from differential clusters of fALFF, ALFF, and PerAF showed reductions between the left precuneus and bilateral occipital lobe, the left precuneus and left paracentral lobule, and within the occipital lobes among patients with BPPV.</p> </section> <section> <h3> Conclusion</h3> <p>The spontaneous activity of certain brain regions in the bilateral occipital and frontoparietal lobes of patients with BPPV was reduced, whereas the activity in the cerebellar vermis was increased. Additionally, there were reductions in FC between the precuneus and occipital cortex or paracentral lobule, as well as within the occipital cortex. The functional alterations in these brain regions may be associated with the inhibitory interaction and functional integration of visual, vestibular, and sensorimotor systems. The functional alterations observed in the visual cortex and precu
研究目的本研究旨在分析接受过复位手法的良性阵发性位置性眩晕(BPPV)患者的静息态功能磁共振成像(rs-fMRI)特征及临床意义:本研究从2018年3月至2021年8月共招募了38名接受过复位手法治疗的BPPV患者和38名匹配的健康对照组(HCs)。采用成像分析软件进行功能图像预处理和指标计算,主要包括低频波动振幅(ALFF)、分数ALFF(fALFF)、波动振幅百分比(PerAF)和基于种子的功能连接性(FC)。此外,还对BPPV患者和HCs患者的各项功能指标进行了统计分析,并与临床数据进行了相关性分析:结果:与 HCs 相比,BPPV 患者的 ALFF、fALFF 和 PerAF 值均有所下降,主要集中在双侧枕叶。此外,小脑近端蚓部的 ALFF 和 fALFF 值与 HCs 相比有所增加。BPPV患者双侧旁中心小叶、右侧辅助运动区(SMA)和左侧楔前区的PerAF值下降,并与复位一周后(W1)的眩晕视觉模拟量表(VAS)评分呈负相关。此外,在左侧纺锤回和舌回,PerAF 值与初次就诊时(W0)的眩晕障碍量表(DHI)评分呈负相关。使用 fALFF、ALFF 和 PerAF 差异群的种子进行的基于种子的 FC 分析表明,在 BPPV 患者中,左侧楔前叶和双侧枕叶之间、左侧楔前叶和左侧枕旁小叶之间以及枕叶内部的活动减少:结论:BPPV 患者双侧枕叶和顶叶某些脑区的自发活动减少,而小脑蚓部的活动增加。此外,楔前叶与枕叶皮质或枕叶旁中心小叶之间以及枕叶皮质内部的FC也有所降低。这些脑区的功能改变可能与视觉、前庭和感觉运动系统的抑制性相互作用和功能整合有关。在视觉皮层和楔前皮层观察到的功能改变可能是与残余眩晕有关的适应性反应。
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引用次数: 0
Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis 神经质与创伤后应激障碍:孟德尔随机分析
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70041
Zifan You, Shanshan Chen, Jinsong Tang

Objective

Epidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the development of PTSD.

Method

We obtained data on three neuroticism clusters, PTSD, and nine other psychiatric disorders from genome-wide association studies summary statistics and employed univariable, multivariable, and mediation MR analyses to explore causal associations among them.

Results

Neuroticism clusters were linked with PTSD (depressed affect (odds ratio [OR]: 2.94 [95% confidence interval: 2.21–3.92]); SESA (2.69 [1.95–3.71]; worry (1.81 [1.37–2.99])). Neuroticism clusters were also associated with psychiatric disorders, with the depressed effect on panic disorder (PD) (2.60 [1.14–5.91]), SESA on anorexia nervosa (AN) (2.77 [1.95–3.94]) and schizophrenia (2.55 [1.99–3.25]), worry on major depressive disorder (MDD) (2.58 [2.19–3.05]). In multivariable MR, only the SESA-PTSD association remained (2.60 [2.096, 3.107]) while worry-PTSD and depressed affect-PTSD associations attenuated to nonsignificance. Mediation MR analyses suggested that PD mediated 3.76% of the effect of depressed effect on PTSD and AN mediated 10.33% of the effect of SESA on PTSD.

Conclusion

Delving deeper into neuroticism clusters, we comprehensively understand the role of neuroticism in PTSD.

目的:流行病学研究显示,神经质与创伤后应激障碍(PTSD)之间存在尚未确定的关联,因此我们进行了泯灭随机化(MR)分析,以研究神经质集群中的担忧、抑郁情绪以及对环境压力和逆境的敏感性(SESA)是否与创伤后应激障碍的发展有关:我们从全基因组关联研究的汇总统计中获得了三个神经质群组、创伤后应激障碍和其他九种精神疾病的数据,并采用单变量、多变量和中介MR分析来探讨它们之间的因果关联:神经质群组与创伤后应激障碍(情绪低落(几率比[OR]:2.94 [95%置信区间:2.21-3.92]);SESA(2.69 [1.95-3.71];担忧(1.81 [1.37-2.99]))有关。神经质群组也与精神障碍有关,抑郁对惊恐障碍(PD)(2.60 [1.14-5.91] )、SESA 对神经性厌食症(AN)(2.77 [1.95-3.94] )和精神分裂症(2.55 [1.99-3.25])、担忧对重度抑郁障碍(MDD)(2.58 [2.19-3.05])有影响。在多变量磁共振分析中,只有 SESA 与创伤后应激障碍的相关性保持不变(2.60 [2.096, 3.107]),而担忧与创伤后应激障碍和抑郁情绪与创伤后应激障碍的相关性则减弱至无显著性。中介MR分析表明,PD中介了抑郁对创伤后应激障碍影响的3.76%,AN中介了SESA对创伤后应激障碍影响的10.33%:通过深入研究神经质群组,我们全面了解了神经质在创伤后应激障碍中的作用。
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引用次数: 0
The Monocyte-to-Lymphocyte Ratio Was Associated With Intraplaque Neovascularization of the Carotid Artery on AngioPLUS 单核细胞与淋巴细胞比率与 AngioPLUS 显示的颈动脉斑块内新生血管有关。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70058
Mingfeng Zhai, Xiao Sun, Jian Wang, Jimei Xu, Fuqin Bian, Menglin Wu, Yafei Yang, Hongwei Chen, Jinghong Lu

Background

The monocyte–lymphocyte ratio (MLR) is a hematological test parameter that reflects the status of both monocytes and lymphocytes as inflammatory cells. This study aims to investigate the relationship between MLR and carotid intraplaque neovascularization (IPN) in patients with asymptomatic carotid stenosis.

Methods

We performed the Angio Planewave Ultrasensitive (AngioPLUS) screening for patients with carotid plaques. The carotid plaque stability was evaluated by semiquantitative visual grading of carotid IPN. Binary logistic regression models were performed to determine the associations between different clinical and laboratory indicators and the presence of high IPN.

Results

A total of 160 patients were eventually enrolled with 99 in the low IPN group (Scores 0–1) and 61 in the high IPN group (Score 2). Univariate logistic regression showed that age, monocytes, lymphocytes, glycated hemoglobin (HbA1c), fibrinogen, d-dimmer, and MLR were significantly associated with the presence of high IPN (all p < 0.05). Multivariate logistic regression models showed that MLR was significantly associated with the presence of high IPN after adjusting for other covariates. An MLR value of 32.9 was the optimal cutoff value to differentiate high and low IPN. High MLR was also significantly correlated with the presence of high IPN (odds ratio [OR] = 4.08, 95% confidence interval [CI]: 1.69–9.88, p = 0.002) when included in the above multivariate logistic regression model.

Conclusion

Elevated MLR is closely associated with the presence of high IPN and may serve as a surrogate biomarker for carotid IPN.

背景:单核细胞-淋巴细胞比值(MLR)是反映单核细胞和淋巴细胞作为炎症细胞状态的血液学检测参数。本研究旨在探讨无症状颈动脉狭窄患者的单核细胞-淋巴细胞比值与颈动脉斑块内新生血管(IPN)之间的关系:我们对颈动脉斑块患者进行了Angio Planewave Ultrasensitive(AngioPLUS)筛查。通过对颈动脉IPN进行半定量视觉分级来评估颈动脉斑块的稳定性。通过二元逻辑回归模型确定不同临床和实验室指标与高IPN之间的关联:最终共有 160 名患者入选,其中低 IPN 组(0-1 分)99 人,高 IPN 组(2 分)61 人。单变量逻辑回归显示,年龄、单核细胞、淋巴细胞、糖化血红蛋白(HbA1c)、纤维蛋白原、d-二聚体和 MLR 与高 IPN 存在显著相关(均为 p 结论:MLR 升高与高 IPN 密切相关:MLR 升高与高 IPN 密切相关,可作为颈动脉 IPN 的替代生物标志物。
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引用次数: 0
Causal Relationship Between Post-Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study 创伤后应激障碍与免疫细胞特征之间的因果关系:孟德尔随机化研究》。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70073
Jian Wang, Yuan Shao, Xianhua Deng, Jianbin Du

Introduction

Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that occurs after exposure to catastrophic-level experiences. Although alterations in immune function have been identified in individuals with PTSD, the causal relationship between the two remains unclear.

Methods

To investigate the causal relationship between PTSD and immune function, we conducted the forward and backward two-sample Mendelian randomization (MR) analyses, based on summary-level genome-wide association studies (GWAS) data on PTSD and immune cell traits.

Results

For the forward MR analysis, PTSD was found to reduce the levels of CD62L− dendritic cell (DC) (beta = −0.254, FDR = 0.01), CD86+ myeloid DC (beta = −0.238, FDR = 0.014), CD62L− myeloid DC (beta = −0.26, FDR = 0.01), CD62L− CD86+ myeloid DC absolute count (beta = −0.264, FDR = 0.024), and CD62L− CD86+ myeloid DC (beta = −0.328, FDR = 0.002). In contrast, PTSD was observed to increase the level of CD28− CD8dim T-cell absolute count (beta = 0.27, FDR = 0.029). For the backward MR analysis, the odds ratio (OR) for CD33 on CD33dim HLA DR+ CD11b− in relation to PTSD risk was found to be 1.045 (95% CI = 1.021–1.069, FDR = 0.008). The OR for FSC-A on HLA DR+ CD8br was 1.048 (95% CI = 1.018–1.079, FDR = 0.039) and for CCR2 on CD14− CD16+ monocyte was 1.059 (95% CI = 1.027–1.092, FDR = 0.008). No significant pleiotropy was detected in both forward and backward MR analyses.

Conclusion

The bidirectional MR study shed light on the intricate interplay between immune function and PTSD. The identification of a bidirectional causal relationship between T cells and PTSD opens new avenues for considering innovative approaches to the prevention and early intervention of PTSD.

简介创伤后应激障碍(PTSD)是一种使人衰弱的心理疾病,发生于遭受灾难性经历之后。虽然已发现创伤后应激障碍患者的免疫功能发生了改变,但两者之间的因果关系仍不清楚:为了研究创伤后应激障碍与免疫功能之间的因果关系,我们根据创伤后应激障碍和免疫细胞特质的全基因组关联研究(GWAS)数据,进行了正向和反向双样本孟德尔随机化(MR)分析:结果:在前向 MR 分析中,发现创伤后应激障碍会降低 CD62L- 树突状细胞(DC)(β = -0.254,FDR = 0.01)、CD86+ 髓样 DC(β = -0.238,FDR = 0.014)、CD62L- 髓样 DC(β = -0.26,FDR = 0.01)、CD62L- CD86+ 髓样 DC 绝对计数(β = -0.264,FDR = 0.024)和 CD62L- CD86+ 髓样 DC(β = -0.328,FDR = 0.002)。相反,创伤后应激障碍会增加 CD28- CD8dim T 细胞绝对计数水平(β = 0.27,FDR = 0.029)。在反向 MR 分析中,CD33dim HLA DR+ CD11b- 上的 CD33 与创伤后应激障碍风险的比值比 (OR) 为 1.045(95% CI = 1.021-1.069,FDR = 0.008)。HLA DR+ CD8br 的 FSC-A OR 为 1.048(95% CI = 1.018-1.079,FDR = 0.039),CD14- CD16+ 单核细胞的 CCR2 OR 为 1.059(95% CI = 1.027-1.092,FDR = 0.008)。正向和反向磁共振分析均未发现明显的多向性:双向磁共振研究揭示了免疫功能与创伤后应激障碍之间错综复杂的相互作用。T细胞与创伤后应激障碍之间双向因果关系的确定为考虑预防和早期干预创伤后应激障碍的创新方法开辟了新途径。
{"title":"Causal Relationship Between Post-Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study","authors":"Jian Wang,&nbsp;Yuan Shao,&nbsp;Xianhua Deng,&nbsp;Jianbin Du","doi":"10.1002/brb3.70073","DOIUrl":"10.1002/brb3.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that occurs after exposure to catastrophic-level experiences. Although alterations in immune function have been identified in individuals with PTSD, the causal relationship between the two remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To investigate the causal relationship between PTSD and immune function, we conducted the forward and backward two-sample Mendelian randomization (MR) analyses, based on summary-level genome-wide association studies (GWAS) data on PTSD and immune cell traits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For the forward MR analysis, PTSD was found to reduce the levels of CD62L− dendritic cell (DC) (beta = −0.254, FDR = 0.01), CD86+ myeloid DC (beta = −0.238, FDR = 0.014), CD62L− myeloid DC (beta = −0.26, FDR = 0.01), CD62L− CD86+ myeloid DC absolute count (beta = −0.264, FDR = 0.024), and CD62L− CD86+ myeloid DC (beta = −0.328, FDR = 0.002). In contrast, PTSD was observed to increase the level of CD28− CD8dim T-cell absolute count (beta = 0.27, FDR = 0.029). For the backward MR analysis, the odds ratio (OR) for CD33 on CD33dim HLA DR+ CD11b− in relation to PTSD risk was found to be 1.045 (95% CI = 1.021–1.069, FDR = 0.008). The OR for FSC-A on HLA DR+ CD8br was 1.048 (95% CI = 1.018–1.079, FDR = 0.039) and for CCR2 on CD14− CD16+ monocyte was 1.059 (95% CI = 1.027–1.092, FDR = 0.008). No significant pleiotropy was detected in both forward and backward MR analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The bidirectional MR study shed light on the intricate interplay between immune function and PTSD. The identification of a bidirectional causal relationship between T cells and PTSD opens new avenues for considering innovative approaches to the prevention and early intervention of PTSD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic immune-inflammation index predicts short-term mortality in acute ischemic stroke with severe stenosis of internal carotid artery associated pneumonia 全身免疫炎症指数可预测颈内动脉严重狭窄伴肺炎的急性缺血性中风患者的短期死亡率。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70047
Yi Yang, Peng He, Yongbo Zhang

Background

We aimed to investigate the relationship between systemic immune-inflammation index (SII) and short-term mortality in acute ischemic stroke (AIS) with internal carotid artery (ICA) severe stenosis and stroke associated pneumonia (SAP) patients.

Methods

Information on general demographic, laboratory data, CT angiography, magnetic resonance angiography, or digital subtraction angiography were obtained. The predictive power was evaluated by assessing the area under the receiver operating characteristic (ROC) curve. The logistic regression was performed to assess the association of SII and short-term mortality in severe stenosis ICA-AIS and SAP patients.

Result

Among 342 patients with severe stenosis ICA-AIS and SAP, death occurred in 66 patients during 120 days follow-up. Multivariate regression analyses indicated that increased SII predicts higher mortality in 120 days follow-up, and the risk of short-term mortality in SII > 666.31 × 109/L group is increased 4.671-fold. Patients with SII > 666.31 × 109/L had higher proportion of male, hypertension, smoking, higher admission NIHSS score, higher systolic blood pressure, and higher proportion of 120 days mortality. Higher SII predicted a worse 120 days mortality was worked out by Kaplan–Meier methods.

Conclusion

An elevated SII was remarkably associated with 120 days mortality in severe stenosis ICA-AIS and SAP patients.

研究背景我们旨在研究颈内动脉(ICA)严重狭窄的急性缺血性卒中(AIS)和卒中相关肺炎(SAP)患者的全身免疫炎症指数(SII)与短期死亡率之间的关系:获取一般人口统计学、实验室数据、CT 血管造影术、磁共振血管造影术或数字减影血管造影术的信息。通过评估接收者操作特征曲线(ROC)下的面积来评估预测能力。对严重狭窄的ICA-AIS和SAP患者的SII与短期死亡率的关系进行了逻辑回归评估:结果:在342例重度狭窄ICA-AIS和SAP患者中,有66例患者在120天的随访期间死亡。多变量回归分析表明,SII的增加预示着随访120天的死亡率会升高,SII>666.31×109/L组的短期死亡风险增加了4.671倍。SII > 666.31 × 109/L 组患者中男性、高血压、吸烟比例较高,入院时 NIHSS 评分较高,收缩压较高,120 天死亡率较高。通过卡普兰-梅耶法计算,SII越高,120天死亡率越低:结论:SII升高与严重狭窄的ICA-AIS和SAP患者的120天死亡率明显相关。
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引用次数: 0
Acute Augmented Effect of Virtual Reality (VR)–Integrated Relaxation and Mindfulness Exercising on Anxiety and Insomnia Symptoms: A Retrospective Analysis of 103 Anxiety Disorder Patients With Prominent Insomnia 虚拟现实(VR)结合放松和正念练习对焦虑和失眠症状的急性增强效应:对103名焦虑症和失眠症患者的回顾性分析。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70060
Hao Zhou, Cuijie Chen, Jinxi Liu, Changhe Fan
<div> <section> <h3> Background</h3> <p>Anxiety disorder is one of the most common mental disorders and often accompanied with sleep disturbance which can in turn exacerbate anxiety symptoms, creating a vicious cycle. In addition to psychopharmacological therapy, the effectiveness of psychotherapy as cognitive behavioral therapy (CBT) for treating anxiety disorders and insomnia has been well documented and widely accepted, but it is labor-intensive and costly. However, virtual reality (VR)–integrated CBT may improve this condition but needs more evidences to support its extensive application in routine clinical practice.</p> </section> <section> <h3> Objectives</h3> <p>This explorative study was aimed to conduct a retrospective analysis to evaluate the acute (2 weeks) augmented effect of VR-integrated relaxation and mindfulness exercising in improving anxiety and insomnia symptoms for patients who were diagnosed with anxiety disorders and concurrently with prominent insomnia symptoms and admitted to the Department of Psychiatry, The Affiliated Guangdong Second Provincial General Hospital of Jinan University during January 2021 to June 2021.</p> </section> <section> <h3> Methods</h3> <p>All patients who were admitted to the department of psychiatry during January 1, 2021 to June 30, 2021 were screened with inclusion criteria and exclusion criteria, and the sociodemographic and clinical data of those included patients were collected from the electronic medical record system of the hospital using a self-designed case report form (CRF). Subjects who were administrated with medication alone were designated as conventional group, and those receiving treatment of medication combined with VR-integrated CBT (VR relaxation and mindfulness exercising) as VR group. The baseline and 2-week posttreatment data were compared between the two groups.</p> </section> <section> <h3> Results</h3> <p>In total, there were 103 patients (70 female, 68%) included in the study. Among all, 68 (66.02%) were designated as the “VR group,” and 35 (33.98%) as the “conventional group.” The majority of patients (67%) were diagnosed with generalized anxiety disorder (GAD). Twenty-three (22.3%) patients had a comorbid diagnosis with primary insomnia, and insomnia was just one of the accompanying symptoms with anxiety for the rest 80 subjects. No statistically significant differences were found between VR and conventional groups in all baseline sociodemographic and clinical characteristics except for occupation. There were statistically significant differences for the remission rates of
背景介绍焦虑症是最常见的精神障碍之一,通常伴有睡眠障碍,而睡眠障碍又会加重焦虑症状,形成恶性循环。除精神药物疗法外,认知行为疗法(CBT)等心理疗法对治疗焦虑症和失眠症的有效性也得到了充分的证明和广泛的认可,但这种疗法耗费大量人力物力,而且成本高昂。然而,整合了虚拟现实技术(VR)的认知行为疗法可能会改善这种状况,但还需要更多证据来支持其在常规临床实践中的广泛应用:本探索性研究旨在对2021年1月至2021年6月期间,暨南大学附属广东省第二综合医院精神科收治的被诊断为焦虑症并同时伴有明显失眠症状的患者进行回顾性分析,评估虚拟现实整合放松和正念训练在改善焦虑和失眠症状方面的急性(2周)增强效果:方法:根据纳入标准和排除标准对2021年1月1日至2021年6月30日期间精神科收治的所有患者进行筛选,并使用自行设计的病例报告表(CRF)从医院的电子病历系统中收集纳入患者的社会人口学和临床数据。仅接受药物治疗的受试者被定为常规组,而接受药物治疗并结合VR-CBT(VR放松和正念练习)的受试者被定为VR组。比较两组患者的基线和治疗后两周的数据:共有 103 名患者(70 名女性,占 68%)参与研究。其中 68 人(66.02%)被指定为 "VR 组",35 人(33.98%)被指定为 "常规组"。大多数患者(67%)被诊断为广泛性焦虑症(GAD)。23名患者(22.3%)合并有原发性失眠诊断,其余80名受试者的失眠只是焦虑症的伴随症状之一。除职业外,VR 组和传统组在所有基线社会人口学和临床特征方面均无明显统计学差异。在焦虑症状或失眠症状的缓解率以及汉密尔顿焦虑评分量表或失眠严重程度指数总分的降低率方面,传统组和 VR 组之间存在统计学意义上的显著差异。无论是焦虑症还是失眠症,VR 组的缓解率或得分降低率均高于常规组。在对 "职业 "这一变量进行控制后,仍存在稳健的差异:为期两周的增强型 VR 综合放松和正念练习对缓解焦虑和失眠症状有显著疗效,值得推荐用于常规临床实践。需要进一步开展前瞻性随机研究,将其与传统的CBT进行比较,探讨其对焦虑和失眠的急性和长期影响。
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引用次数: 0
Cortical activation during the verbal fluency task for obstructive sleep apnea patients with depressive symptoms: A multi-channel fNIRS study 有抑郁症状的阻塞性睡眠呼吸暂停患者在语言流畅性任务中的皮层激活:多通道 fNIRS 研究。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-29 DOI: 10.1002/brb3.70038
Xuan Zhang, Ning Zhang, Yang Yang, Shuo Wang, Ping Yu, Chun-Xue Wang

Study objective

The aim of our study was to elucidate differences in brain activity patterns among obstructive sleep apnea (OSA) patients, OSA patients with depressive symptoms, and healthy controls (HCs). We also investigated the relationship between brain function and depression in OSA patients.

Methods

A total of 95 subjects were included in the study, including 34 OSA patients without depressive symptoms, 31 OSA patients with depressive symptoms, and 30 HCs. The 53-channel functional near-infrared spectroscopy (fNIRS) was used to monitor the concentration of oxy-hemoglobin (Oxy-Hb) in the brain, whereas the participants performed the verbal fluency task, and the degree of depression was scored using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Hierarchical regression models were conducted to analyze the association of fNIRS features with depressive symptom.

Results

The Oxy-Hb changes of the three groups were significantly different in Channels 25 (H = 9.878, p = .007) and 43 (H = 6.957, p = .031). Inter-group comparisons showed that the Oxy-Hb change of Channel 25 (located in the dorsolateral prefrontal cortex [DLPFC]) in OSA group was less than that in HC group (p = .006), and the Oxy-Hb change of Channel 43 (located in the right frontal polar region) in OSA group with depression was less than that in OSA group (p = .025). Spearman's test showed that there was a significant negative correlation between HAMD-17 scores and mean Oxy-Hb changes in Channel 43 (r = −.319, p < .05) in the OSA patients. Using hierarchical regression, Oxy-Hb changes in Channel 43 accounted for a significant proportion of the variation in outcome variables, even when accounting for other polysomnography features.

Conclusions:

Changes in the hemodynamic response of DLPFC may be a potential mechanism of executive dysfunction in OSA patients. And the right frontal polar region may be significant in assessing depressive symptoms in patients with OSA.

研究目的我们的研究旨在阐明阻塞性睡眠呼吸暂停(OSA)患者、伴有抑郁症状的OSA患者和健康对照组(HCs)之间大脑活动模式的差异。我们还研究了 OSA 患者大脑功能与抑郁症之间的关系:研究共纳入 95 名受试者,包括 34 名无抑郁症状的 OSA 患者、31 名有抑郁症状的 OSA 患者和 30 名健康对照组(HCs)。采用 53 通道功能性近红外光谱(fNIRS)监测大脑中氧血红蛋白(Oxy-Hb)的浓度,同时让受试者完成语言流畅性任务,并使用 17 项汉密尔顿抑郁评定量表(HAMD-17)对受试者的抑郁程度进行评分。研究人员采用层次回归模型分析了fNIRS特征与抑郁症状的关联:结果:三组的血氧-血红蛋白变化在通道 25(H = 9.878,p = .007)和通道 43(H = 6.957,p = .031)有显著差异。组间比较显示,OSA组第25通道(位于背外侧前额叶皮层[DLPFC])的Oxy-Hb变化小于HC组(p = .006),OSA伴抑郁组第43通道(位于右额极区)的Oxy-Hb变化小于OSA组(p = .025)。DLPFC血流动力学反应的变化可能是导致OSA患者执行功能障碍的潜在机制。右额极区可能对评估 OSA 患者的抑郁症状有重要意义。
{"title":"Cortical activation during the verbal fluency task for obstructive sleep apnea patients with depressive symptoms: A multi-channel fNIRS study","authors":"Xuan Zhang,&nbsp;Ning Zhang,&nbsp;Yang Yang,&nbsp;Shuo Wang,&nbsp;Ping Yu,&nbsp;Chun-Xue Wang","doi":"10.1002/brb3.70038","DOIUrl":"10.1002/brb3.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Study objective</h3>\u0000 \u0000 <p>The aim of our study was to elucidate differences in brain activity patterns among obstructive sleep apnea (OSA) patients, OSA patients with depressive symptoms, and healthy controls (HCs). We also investigated the relationship between brain function and depression in OSA patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 95 subjects were included in the study, including 34 OSA patients without depressive symptoms, 31 OSA patients with depressive symptoms, and 30 HCs. The 53-channel functional near-infrared spectroscopy (fNIRS) was used to monitor the concentration of oxy-hemoglobin (Oxy-Hb) in the brain, whereas the participants performed the verbal fluency task, and the degree of depression was scored using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Hierarchical regression models were conducted to analyze the association of fNIRS features with depressive symptom.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Oxy-Hb changes of the three groups were significantly different in Channels 25 (<i>H</i> = 9.878, <i>p</i> = .007) and 43 (<i>H</i> = 6.957, <i>p</i> = .031). Inter-group comparisons showed that the Oxy-Hb change of Channel 25 (located in the dorsolateral prefrontal cortex [DLPFC]) in OSA group was less than that in HC group (<i>p</i> = .006), and the Oxy-Hb change of Channel 43 (located in the right frontal polar region) in OSA group with depression was less than that in OSA group (<i>p</i> = .025). Spearman's test showed that there was a significant negative correlation between HAMD-17 scores and mean Oxy-Hb changes in Channel 43 (<i>r</i> = −.319, <i>p</i> &lt; .05) in the OSA patients. Using hierarchical regression, Oxy-Hb changes in Channel 43 accounted for a significant proportion of the variation in outcome variables, even when accounting for other polysomnography features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions:</h3>\u0000 \u0000 <p>Changes in the hemodynamic response of DLPFC may be a potential mechanism of executive dysfunction in OSA patients. And the right frontal polar region may be significant in assessing depressive symptoms in patients with OSA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and validation of AQUA CHILD—Pre-aquatic questionnaire assessing child development AQUA CHILD--水上运动前儿童发展评估问卷的设计与验证。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-29 DOI: 10.1002/brb3.70033
Merav Hadar Frumer, Huib Ten Napel, Maria José Yuste-Sánchez, Isabel Rodríguez-Costa

Purpose

We developed a proxy questionnaire for parents of children with Developmental Delay (DD) to provide comprehensive information for instructors about the child's functioning before participating in aquatic activities. This dedicated information will enable a high-quality treatment plan to promote the child's functioning in everyday life.

Methods

Based on the International Classification of Functioning, Disability, and Health (ICF) Coreset development and linking rules method, a set of questions was constructed in a preliminary process. A draft version was sent to instructors and parents in Israel. Seventy-five questionnaires from instructors and 25 from parents returned to the statistical analysis procedure. Reliability and face validity were analyzed by experts.

Results and conclusions

The questionnaire showed high validity and reliability for its purposes and allowed self-completion by the parents.

目的:我们为发育迟缓(DD)儿童的家长编制了一份代理问卷,以便在参加水上活动前为指导员提供有关儿童功能的全面信息。这些专门信息将有助于制定高质量的治疗计划,以促进儿童在日常生活中的功能:方法:根据《国际功能、残疾和健康分类》(ICF)核心集开发和链接规则方法,初步构建了一套问题。初稿发给了以色列的教师和家长。有 75 份来自指导教师和 25 份来自家长的问卷返回统计分析程序。专家对问卷的信度和面效进行了分析:问卷显示出较高的有效性和可靠性,符合其目的,并允许家长自行填写。
{"title":"Design and validation of AQUA CHILD—Pre-aquatic questionnaire assessing child development","authors":"Merav Hadar Frumer,&nbsp;Huib Ten Napel,&nbsp;Maria José Yuste-Sánchez,&nbsp;Isabel Rodríguez-Costa","doi":"10.1002/brb3.70033","DOIUrl":"10.1002/brb3.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>We developed a proxy questionnaire for parents of children with Developmental Delay (DD) to provide comprehensive information for instructors about the child's functioning before participating in aquatic activities. This dedicated information will enable a high-quality treatment plan to promote the child's functioning in everyday life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the International Classification of Functioning, Disability, and Health (ICF) Coreset development and linking rules method, a set of questions was constructed in a preliminary process. A draft version was sent to instructors and parents in Israel. Seventy-five questionnaires from instructors and 25 from parents returned to the statistical analysis procedure. Reliability and face validity were analyzed by experts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and conclusions</h3>\u0000 \u0000 <p>The questionnaire showed high validity and reliability for its purposes and allowed self-completion by the parents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The causal association between epilepsy and amyotrophic lateral sclerosis: A two-sample Mendelian randomization study 癫痫与肌萎缩侧索硬化症之间的因果关系:双样本孟德尔随机研究
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-27 DOI: 10.1002/brb3.70018
Yayong Cui, Junyu Chen, Hong Li, Dong Zheng, Xiaolei Shi

Objectives

Epilepsy and amyotrophic lateral sclerosis (ALS) are common neurological disorders. The association between the two disorders has been raised in observational studies. However, it is uncertain to what extent they have mutual causal effects. In this study, we aimed to investigate their causal association using a two-sample Mendelian randomization (MR) method.

Methods

We performed a two-sample bidirectional MR analysis to evaluate the causal association of epilepsy with the risk of ALS. Publicly published genome-wide association study statistics for epilepsy and ALS were used in the study. The primary analysis included genetic variants with a p value of less than 1 × 10–5 as instrumental variables. We applied several alternative methods, including inverse variance weighting, weighted median, simple mode, weighted mode, MR-Egger regression and MR pleiotropy residual sum and outlier, and statistical graphs to assess the associations of epilepsy and its subtype with the risk of ALS. Reverse MR analyses were also performed to examine the association of ALS with the risk of epilepsy.

Results

The primary MR analysis found no causal effect of epilepsy on risk of ALS (odds ration [OR]: 1.133, 95% confidence interval [CI]: 0.964–1.332, p = .130). Among subtypes of epilepsy, it also failed to observe any causal association between general epilepsy and ALS (OR: 1.036, 95% CI: 0.969–1.108, P = .300). However, focal epilepsy contributed to an increase in the risk of ALS (OR: 1.177, 95% CI: 1.027–1.348, p = .019). Moreover, the investigation of reverse causalities did not reveal significant results.

Conclusions

The current study supports a causal influence of focal epilepsy on ALS risk. Future studies are needed to explore its potential role in ALS.

目的 癫痫和肌萎缩性脊髓侧索硬化症(ALS)是常见的神经系统疾病。观察性研究发现,这两种疾病之间存在关联。然而,目前还不能确定这两种疾病在多大程度上存在互为因果的效应。在本研究中,我们旨在使用双样本孟德尔随机化(MR)方法研究它们之间的因果关系。 方法 我们进行了双样本双向 MR 分析,以评估癫痫与 ALS 风险的因果关系。研究采用了公开发表的癫痫和 ALS 全基因组关联研究统计数据。主要分析将 p 值小于 1 × 10-5 的遗传变异作为工具变量。我们采用了几种替代方法,包括反方差加权法、加权中位数法、简单模式法、加权模式法、MR-Egger 回归法和 MR pleiotropy 残差和离群值法,以及统计图表法来评估癫痫及其亚型与 ALS 风险的关联。此外,还进行了反向磁共振分析,以研究 ALS 与癫痫风险的关联。 结果 主要的 MR 分析发现,癫痫与 ALS 风险没有因果关系(赔率 [OR]:1.133,95% 置信区间 [CI]:0.964-1.332, p = .130).在癫痫的亚型中,也没有观察到一般癫痫与 ALS 之间存在任何因果关系(OR:1.036,95% 置信区间:0.969-1.108,P = .300)。然而,局灶性癫痫会导致 ALS 风险增加(OR:1.177,95% CI:1.027-1.348,P = .019)。此外,对反向因果关系的调查也未发现显著结果。 结论 目前的研究支持局灶性癫痫对 ALS 风险的因果影响。未来的研究需要探索其在 ALS 中的潜在作用。
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引用次数: 0
The relationship between menstrual cycle pattern and post-traumatic stress in women following the 2023 earthquake in Turkey 土耳其 2023 年地震后妇女月经周期模式与创伤后应激反应之间的关系
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-25 DOI: 10.1002/brb3.70034
Sibel Kiyak, Serap Batı

Aim

In the aftermath of natural disasters, understanding the intricate links between mental health and physiological responses, such as menstrual cycle patterns, becomes crucial. This study explores the relationship between post-traumatic stress and menstrual irregularities among women of reproductive age residing in regions affected by the 2023 earthquake in Turkey.

Methods

309 women of reproductive age living in 11 provinces affected by the earthquake centered in Kahramanmaraş on February 6, 2023 and declared as disaster areas constituted the study sample. Data were collected online using Google forms nine months after the earthquake. The collected data were obtained using the Participant Information Form, Impact of Events Scale and Post-traumatic Stress Disorder-Short Form. In the data analysis, descriptive statistics such as count, percentage, median, minimum, and maximum were used, along with statistical tests including the Mann–Whitney U test, chi-squared test, multiple logistic regression analysis, and ROC analysis.

Results

In the study, an increase in menstrual irregularities among women was observed following the earthquake (%14.3 to %44.8, p < .001). Risk factors for menstrual irregularities included post-traumatic stress symptoms, comorbid chronic diseases, and smoking. The prevalence of PTSD was found to be 22.7% and this was associated with women with menstrual irregularities. Setting the cut-off score of the IES-R scale at 45.50 resulted in higher sensitivity for detecting irregular menstrual cycles.

Conclusions

Women's menstrual cycles are affected after an earthquake. Therefore, post-earthquake mental health recovery programs should specifically address the protection of women's physical and mental health. This comprehensive approach can reduce the effects of earthquake-induced stress and trauma.

自然灾害发生后,了解心理健康与生理反应(如月经周期模式)之间错综复杂的联系变得至关重要。本研究探讨了居住在土耳其 2023 年地震灾区的育龄妇女的创伤后应激反应与月经不调之间的关系。
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引用次数: 0
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Brain and Behavior
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