Huangxin Zhu, Qingan Fu, Juanjuan Hu, Yihong Wu, Jun Min
Background
Cognitive decline among the elderly is an increasingly prominent issue amid global population aging. Decanoic acid has been hypothesized to be associated with cognitive function. However, the relationship of decanoic acid with cognitive function in the elderly remains unclear.
Methods
This study analyzed the participants aged 60 years and older from National Health and Nutrition Examination Survey (NHANES) 2011–2014. Dietary decanoic acid (DDA) intake was derived from two 24-h dietary recalls. Cognitive function was assessed via immediate recall test (IRT), delayed recall test (DRT), animal fluency test (AFT), and digit symbol substitution test (DSST). Higher scores on these tests indicated better cognitive performance. Weighted multivariate linear regression, restricted cubic spline (RCS) curves, subgroup analyses, and mediating analysis were used to explore the relationship between DDA intake and cognitive function.
Results
A total of 2246 older adults were included in this study. After adjusting for confounding variables, DDA intake was positively associated with comprehensive cognitive function (β = 0.539, 95% CI: 0.168–0.910, p = 0.007). The RCS curve shows a positive correlation between DDA intake and comprehensive cognitive function (p-value for overall < 0.001, p-value for nonlinearity = 0.050). Subgroup analyses showed that the association remained relatively consistent across subgroups (all p for interaction > 0.05). Mediating analysis revealed that the indirect effects of hypertension and diabetes accounted for 27.53% and 24.33% of the total effect, respectively.
Conclusion
DDA intake is positively associated with global cognitive function in older adults. Hypertension and diabetes may partially mediate this relationship. The cross-sectional study design limits causal inference, and prospective or interventional studies should be conducted in the future.
{"title":"Associations of Dietary Decanoic Acid Intake With Cognitive Function in the Elderly and the Mediating Effects of Hypertension and Diabetes: An Analysis From NHANES 2011–2014","authors":"Huangxin Zhu, Qingan Fu, Juanjuan Hu, Yihong Wu, Jun Min","doi":"10.1002/brb3.71180","DOIUrl":"10.1002/brb3.71180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cognitive decline among the elderly is an increasingly prominent issue amid global population aging. Decanoic acid has been hypothesized to be associated with cognitive function. However, the relationship of decanoic acid with cognitive function in the elderly remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study analyzed the participants aged 60 years and older from National Health and Nutrition Examination Survey (NHANES) 2011–2014. Dietary decanoic acid (DDA) intake was derived from two 24-h dietary recalls. Cognitive function was assessed via immediate recall test (IRT), delayed recall test (DRT), animal fluency test (AFT), and digit symbol substitution test (DSST). Higher scores on these tests indicated better cognitive performance. Weighted multivariate linear regression, restricted cubic spline (RCS) curves, subgroup analyses, and mediating analysis were used to explore the relationship between DDA intake and cognitive function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 2246 older adults were included in this study. After adjusting for confounding variables, DDA intake was positively associated with comprehensive cognitive function (<i>β</i> = 0.539, 95% CI: 0.168–0.910, <i>p</i> = 0.007). The RCS curve shows a positive correlation between DDA intake and comprehensive cognitive function (<i>p</i>-value for overall < 0.001, <i>p</i>-value for nonlinearity = 0.050). Subgroup analyses showed that the association remained relatively consistent across subgroups (all <i>p</i> for interaction > 0.05). Mediating analysis revealed that the indirect effects of hypertension and diabetes accounted for 27.53% and 24.33% of the total effect, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DDA intake is positively associated with global cognitive function in older adults. Hypertension and diabetes may partially mediate this relationship. The cross-sectional study design limits causal inference, and prospective or interventional studies should be conducted in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146059922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Background</h3> <p>High school physical education courses commonly face problems such as low student participation and insufficient intrinsic motivation. To address these issues, this study focuses on exploring the impact mechanism and cross-group applicability of support strategies for autonomy, competence, and relatedness needs on students' motivation, and thus designs and implements a need-supported curriculum intervention program based on Self-Determination Theory (SDT). The research also aims to provide a solution combining theoretical depth and practical feasibility for addressing students' physical health issues, as well as empirical evidence for the implementation of the “integration of sports and education” policy.</p> </section> <section> <h3> Methods</h3> <p>A quasi-experimental research design was adopted, with 180 high school students divided into an experimental group and a control group. The experimental group received a 12-week modular physical education course, which included three core components: self-directed course selection, stratified task arrangement, and collaborative activity participation. In contrast, the control group continued to receive traditional physical education teaching methods throughout the same period. The study focused on measuring and comparing indicators such as students' intrinsic motivation levels, the satisfaction degree of three core needs (autonomy, competence, relatedness), extracurricular exercise behavior, sports injury rate, and academic performance between the two groups.</p> </section> <section> <h3> Results</h3> <p>- Intrinsic motivation improvement: The experimental group showed a significant increase in intrinsic motivation levels, with an effect size of 1.28 standard deviations (d = 1.28), which was significantly higher than that of the control group.</p> <p>- Core needs satisfaction: There were graded differences in the enhancement of the three core needs among the experimental group: autonomy needs (d = 1.12), competence needs (d = 0.95), and relatedness needs (d = 0.83). These three factors drove the internalization of students' intrinsic motivation through a full mediating effect, accounting for 87% of the total variation in motivation improvement.</p> <p>- Cross-group difference (moderation effect): From the perspective of gender difference, girls in the experimental group had a more significant increase in relatedness needs satisfaction (mean difference = 0.22, p 〈 0.05); in terms of exercise foundation, the motivation improvement of students with low exercise foundation was twice that of those with high
{"title":"The Influence of High School Physical Education Curriculum Design Based on Self-Determination Theory on Students' Intrinsic Motivation","authors":"WEN-TAO MENG, Dongjin Liu","doi":"10.1002/brb3.70928","DOIUrl":"10.1002/brb3.70928","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>High school physical education courses commonly face problems such as low student participation and insufficient intrinsic motivation. To address these issues, this study focuses on exploring the impact mechanism and cross-group applicability of support strategies for autonomy, competence, and relatedness needs on students' motivation, and thus designs and implements a need-supported curriculum intervention program based on Self-Determination Theory (SDT). The research also aims to provide a solution combining theoretical depth and practical feasibility for addressing students' physical health issues, as well as empirical evidence for the implementation of the “integration of sports and education” policy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A quasi-experimental research design was adopted, with 180 high school students divided into an experimental group and a control group. The experimental group received a 12-week modular physical education course, which included three core components: self-directed course selection, stratified task arrangement, and collaborative activity participation. In contrast, the control group continued to receive traditional physical education teaching methods throughout the same period. The study focused on measuring and comparing indicators such as students' intrinsic motivation levels, the satisfaction degree of three core needs (autonomy, competence, relatedness), extracurricular exercise behavior, sports injury rate, and academic performance between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>- Intrinsic motivation improvement: The experimental group showed a significant increase in intrinsic motivation levels, with an effect size of 1.28 standard deviations (d = 1.28), which was significantly higher than that of the control group.</p>\u0000 \u0000 <p>- Core needs satisfaction: There were graded differences in the enhancement of the three core needs among the experimental group: autonomy needs (d = 1.12), competence needs (d = 0.95), and relatedness needs (d = 0.83). These three factors drove the internalization of students' intrinsic motivation through a full mediating effect, accounting for 87% of the total variation in motivation improvement.</p>\u0000 \u0000 <p>- Cross-group difference (moderation effect): From the perspective of gender difference, girls in the experimental group had a more significant increase in relatedness needs satisfaction (mean difference = 0.22, p 〈 0.05); in terms of exercise foundation, the motivation improvement of students with low exercise foundation was twice that of those with high","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poststroke cognitive impairment (PSCI) is a common neurological consequence of stroke that significantly impacts patients' quality of life and functional recovery. This meta-analysis aimed to evaluate and compare the efficacy of various treatment modalities for PSCI.
Method
We conducted a systematic search of multiple databases and identified eligible randomized controlled trials (RCTs) investigating treatments for PSCI. Eleven RCTs with 904 participants evaluating seven different interventions were included in the network meta-analysis. The treatments included transcranial direct current stimulation (tDCS), acupuncture, Baduanjin exercise, transcranial ultrasound stimulation (TUS), moderate-intensity aerobic exercise, modified Suanzaoren decoction, and cognitive training alone (control).
Results
Network meta-analysis showed that all interventions demonstrated some degree of efficacy compared to cognitive training alone, with Baduanjin exercise and tDCS ranking highest for improving cognitive function. Publication bias assessment showed no significant bias.
Conclusion
This comprehensive analysis suggests that non-pharmacological interventions, particularly neuromodulation techniques and traditional Chinese exercise, may offer promising approaches for PSCI treatment. These findings provide evidence-based guidance for clinical decision-making, though more large-scale, high-quality RCTs are needed to strengthen these conclusions.
{"title":"Meta-Analysis of Treatment Methods for Poststroke Cognitive Impairment: A Network Analysis of Various Interventions","authors":"Huainan Li, Zhiqiang Zhao, Peng Qiao, Junlin Wang, Peng Xu, Yun Ye","doi":"10.1002/brb3.71115","DOIUrl":"10.1002/brb3.71115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Poststroke cognitive impairment (PSCI) is a common neurological consequence of stroke that significantly impacts patients' quality of life and functional recovery. This meta-analysis aimed to evaluate and compare the efficacy of various treatment modalities for PSCI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We conducted a systematic search of multiple databases and identified eligible randomized controlled trials (RCTs) investigating treatments for PSCI. Eleven RCTs with 904 participants evaluating seven different interventions were included in the network meta-analysis. The treatments included transcranial direct current stimulation (tDCS), acupuncture, Baduanjin exercise, transcranial ultrasound stimulation (TUS), moderate-intensity aerobic exercise, modified Suanzaoren decoction, and cognitive training alone (control).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Network meta-analysis showed that all interventions demonstrated some degree of efficacy compared to cognitive training alone, with Baduanjin exercise and tDCS ranking highest for improving cognitive function. Publication bias assessment showed no significant bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This comprehensive analysis suggests that non-pharmacological interventions, particularly neuromodulation techniques and traditional Chinese exercise, may offer promising approaches for PSCI treatment. These findings provide evidence-based guidance for clinical decision-making, though more large-scale, high-quality RCTs are needed to strengthen these conclusions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu
Background
Given inconsistent evidence regarding the migraine-Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship.
Methods
GWAS summary statistics for migraine and Alzheimer's disease were acquired from the IEU Open GWAS repository. We implemented a multi-stage MR framework comprising (1) univariate analysis, (2) independent replication, (3) multivariable MR, (4) meta-analysis to evaluate migraine-AD causality.
Results
Univariate results showed OR = 13.43, 95% CI: 2.86-63.16, P < 0.01; replication Mendelian randomization results were OR = 12.64, 2.89-55.38, P < 0.01 with OR = 1.13, 95% CI: 1.06-1.21, P < 0.01, meta-analysis results were OR = 1.14, 95% CI: 1.07- 1.22, P < 0.01. Multivariate Mendelian randomization results were OR = 18.90, 95% CI: 1.69-210.88, P < 0.01.
Conclusion
Considering the observed epidemiological correlations and shared pathophysiological mechanisms between migraine and Alzheimer's disease (AD), we propose that chronic migraine may increase the susceptibility to AD through complex biological interactions. This hypothesis is reinforced by our Mendelian randomization (MR) findings, which support a causal relationship. Therefore, early and effective intervention in migraine management could serve as a promising strategy to mitigate the future risk of AD onset.
背景：考虑到偏头痛与阿尔茨海默病关联的证据不一致，本孟德尔随机化（MR）研究考察了它们之间潜在的因果关系。方法：偏头痛和阿尔茨海默病的GWAS汇总统计数据来自IEU开放GWAS存储库。我们实施了一个多阶段磁共振框架，包括(1)单变量分析，(2)独立复制，(3)多变量磁共振，(4)荟萃分析，以评估偏头痛与ad的因果关系。结果：单因素结果OR = 13.43, 95% CI: 2.86 ~ 63.16, P < 0.01；孟德尔随机化结果OR = 12.64, 2.89 ~ 55.38, P < 0.01, OR = 1.13, 95% CI: 1.06 ~ 1.21, P < 0.01， meta分析结果OR = 1.14, 95% CI: 1.07 ~ 1.22, P < 0.01。多变量孟德尔随机化结果OR = 18.90, 95% CI: 1.69 ~ 210.88, P < 0.01。结论：考虑到偏头痛和阿尔茨海默病（AD）之间的流行病学相关性和共同的病理生理机制，我们提出慢性偏头痛可能通过复杂的生物相互作用增加对AD的易感性。我们的孟德尔随机化（MR）研究结果加强了这一假设，支持因果关系。因此，对偏头痛进行早期有效的干预可以作为一种有希望的策略来降低未来AD发病的风险。
{"title":"Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization","authors":"Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu","doi":"10.1002/brb3.71081","DOIUrl":"10.1002/brb3.71081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Given inconsistent evidence regarding the migraine-Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>GWAS summary statistics for migraine and Alzheimer's disease were acquired from the IEU Open GWAS repository. We implemented a multi-stage MR framework comprising (1) univariate analysis, (2) independent replication, (3) multivariable MR, (4) meta-analysis to evaluate migraine-AD causality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Univariate results showed OR = 13.43, 95% CI: 2.86-63.16, <i>P <</i> 0.01; replication Mendelian randomization results were OR = 12.64, 2.89-55.38, <i>P <</i> 0.01 with OR = 1.13, 95% CI: 1.06-1.21, <i>P <</i> 0.01, meta-analysis results were OR = 1.14, 95% CI: 1.07- 1.22, <i>P <</i> 0.01. Multivariate Mendelian randomization results were OR = 18.90, 95% CI: 1.69-210.88, <i>P <</i> 0.01.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Considering the observed epidemiological correlations and shared pathophysiological mechanisms between migraine and Alzheimer's disease (AD), we propose that chronic migraine may increase the susceptibility to AD through complex biological interactions. This hypothesis is reinforced by our Mendelian randomization (MR) findings, which support a causal relationship. Therefore, early and effective intervention in migraine management could serve as a promising strategy to mitigate the future risk of AD onset.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peng Wang, Zhiyuan An, Yan Huang, Wen Qi, Xu Han, Yuqi Xia, Zhe Chen, Zhenghan Yang, Pengfei Zhao, Yuhe Liu
<div> <section> <h3> Introduction</h3> <p>Some patients with Charcot-Marie-Tooth disease (CMT) exhibit prolonged auditory brainstem response (ABR) latencies or abnormal waveforms, suggesting potential damage to the peripheral auditory nerve or central auditory pathways. Diffusion tensor imaging (DTI), a non-invasive neuroimaging technique, can detect the integrity and functional properties of white matter structures with high sensitivity. However, research on the association between DTI characteristics and ABR changes in patients with CMT remains relatively limited, and whether both modalities reflect synergistic damage to central-peripheral nerve axons or myelin sheaths remains unclear. In this study, we aimed to analyze cerebral white matter microstructural abnormalities in patients with CMT using DTI and explore their correlation with ABR, thereby exploring the pathophysiological mechanisms of the central auditory pathway in patients with CMT.</p> </section> <section> <h3> Methods</h3> <p>This study included 14 patients with CMT and 14 healthy controls. DTI data were acquired using a 3.0T MRI scanner. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The latencies and interpeak latencies of the auditory pathway were measured using ABR. DTI metrics were compared between the two groups, and the relationship between DTI parameters and ABR results was analyzed in patients with CMT.</p> </section> <section> <h3> Results</h3> <p>Compared with the healthy controls, patients with CMT exhibited significantly decreased FA values and significantly increased MD, AD, and RD values in brain regions <i>p</i> < 0.05), including the occipital part of the corona radiata, inferior longitudinal fasciculus, anterior thalamic radiation, and inferior fronto-occipital fasciculus. ABR interpeak latencies correlated positively with FA in the left inferior longitudinal fasciculus and negatively with AD. Three participants did not complete the ABR test. ABR latencies in CMT patients were significantly correlated with AD values in the anterior thalamic radiation and corpus callosum (<i>p</i> < 0.05).</p> </section> <section> <h3> Conclusion</h3> <p>Abnormal central white matter microstructure (axonal degeneration, demyelination) in patients with CMT may lead to auditory pathway dysfunction by impairing neural conduction efficiency. The multimodal correlation analysis of DTI and ABR provides new insights into the mechanism of central nervous system involvement in CMT, suggesting its potential as a cl
{"title":"White Matter Microstructural Correlates of Auditory Brainstem Responses in Patients With Charcot-Marie-Tooth Disease","authors":"Peng Wang, Zhiyuan An, Yan Huang, Wen Qi, Xu Han, Yuqi Xia, Zhe Chen, Zhenghan Yang, Pengfei Zhao, Yuhe Liu","doi":"10.1002/brb3.71142","DOIUrl":"10.1002/brb3.71142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Some patients with Charcot-Marie-Tooth disease (CMT) exhibit prolonged auditory brainstem response (ABR) latencies or abnormal waveforms, suggesting potential damage to the peripheral auditory nerve or central auditory pathways. Diffusion tensor imaging (DTI), a non-invasive neuroimaging technique, can detect the integrity and functional properties of white matter structures with high sensitivity. However, research on the association between DTI characteristics and ABR changes in patients with CMT remains relatively limited, and whether both modalities reflect synergistic damage to central-peripheral nerve axons or myelin sheaths remains unclear. In this study, we aimed to analyze cerebral white matter microstructural abnormalities in patients with CMT using DTI and explore their correlation with ABR, thereby exploring the pathophysiological mechanisms of the central auditory pathway in patients with CMT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 14 patients with CMT and 14 healthy controls. DTI data were acquired using a 3.0T MRI scanner. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The latencies and interpeak latencies of the auditory pathway were measured using ABR. DTI metrics were compared between the two groups, and the relationship between DTI parameters and ABR results was analyzed in patients with CMT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the healthy controls, patients with CMT exhibited significantly decreased FA values and significantly increased MD, AD, and RD values in brain regions <i>p</i> < 0.05), including the occipital part of the corona radiata, inferior longitudinal fasciculus, anterior thalamic radiation, and inferior fronto-occipital fasciculus. ABR interpeak latencies correlated positively with FA in the left inferior longitudinal fasciculus and negatively with AD. Three participants did not complete the ABR test. ABR latencies in CMT patients were significantly correlated with AD values in the anterior thalamic radiation and corpus callosum (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Abnormal central white matter microstructure (axonal degeneration, demyelination) in patients with CMT may lead to auditory pathway dysfunction by impairing neural conduction efficiency. The multimodal correlation analysis of DTI and ABR provides new insights into the mechanism of central nervous system involvement in CMT, suggesting its potential as a cl","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral small vessel disease (CSVD) is a significant contributor to cognitive impairment (CI). Research on CSVD-CI has gained prominence; however, comprehensive bibliometric analysis of the global research landscape in this area is currently lacking. This study aims to address this gap by conducting a thorough bibliometric analysis to identify research hotspots and emerging trends.
Methods
We retrieved relevant literature published from 2001 to 2024 from the web of science (WoS) core collection. using VOSviewer, CiteSpace, R, and Origin 2022, we performed bibliometric and network visualization analyses to examine publication trends, geographical distribution, institutional collaborations, journal metrics, citation patterns, author contributions, co-citation networks, and keyword co-occurrence.
Results
Three distinct phases were identified: foundational (2001–2010), developmental (2011–2018), and accelerated (2019–2024). The United States exhibited the highest citation impact, whereas China reported the highest number of publications. The journals “neurology” and “stroke” emerged as the leading publications. Four major research clusters were revealed: pathophysiological mechanisms (neuroinflammation and oxidative stress), neuroimaging biomarkers (white matter hyperintensities (WMH) and cerebral micro bleeds), clinical manifestations and cognitive assessment, and therapeutic interventions. Emerging trends included blood-brain barrier (BBB) dysfunction, neurovascular coupling, and innovative therapies.
Conclusions
This bibliometric study sheds light on the research hotspots and trends in CSVD-CI over the past two decades, assisting researchers in identifying key focus areas and exploring advancements in this domain.
背景和目的：脑血管病（CSVD）是导致认知障碍（CI）的重要因素。CSVD-CI的研究日益突出；然而，目前缺乏对该领域全球研究格局的综合文献计量分析。本研究旨在透过深入的文献计量分析，找出研究热点和新兴趋势，以弥补这方面的差距。方法：检索web of science （WoS）核心馆藏2001 ~ 2024年发表的相关文献。利用VOSviewer、CiteSpace、R和Origin 2022，我们进行了文献计量和网络可视化分析，以研究出版趋势、地理分布、机构合作、期刊指标、引文模式、作者贡献、共被引网络和关键词共现情况。结果：研究确定了三个不同阶段：基础阶段（2001-2010年）、发展期（2011-2018年）和加速期（2019-2024年）。美国表现出最高的引用影响，而中国报告的出版物数量最多。《神经学》和《中风》杂志成为主要出版物。主要包括病理生理机制（神经炎症和氧化应激）、神经影像学生物标志物（白质高信号（WMH）和脑微出血）、临床表现和认知评估以及治疗干预等四个方面的研究。新出现的趋势包括血脑屏障（BBB）功能障碍、神经血管耦合和创新疗法。结论：本文献计量学研究揭示了近二十年来CSVD-CI的研究热点和趋势，有助于研究人员确定重点领域并探索该领域的进展。
{"title":"Global Research Trends and Hotspots in Cerebral Small Vessel Disease-Related Cognitive Impairment: A Bibliometric Analysis (2001–2024)","authors":"Kuihua Wang, Xiaohui Ji, Hui Li, Xiaoyang Wang, Xiaoyue Jin, YanJun Lin, Qiao Wang, Haizhen Xu, Jianxin Ye, Xiaoping Cui, Yonghui Liang","doi":"10.1002/brb3.71167","DOIUrl":"10.1002/brb3.71167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and aims</h3>\u0000 \u0000 <p>Cerebral small vessel disease (CSVD) is a significant contributor to cognitive impairment (CI). Research on CSVD-CI has gained prominence; however, comprehensive bibliometric analysis of the global research landscape in this area is currently lacking. This study aims to address this gap by conducting a thorough bibliometric analysis to identify research hotspots and emerging trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrieved relevant literature published from 2001 to 2024 from the web of science (WoS) core collection. using VOSviewer, CiteSpace, R, and Origin 2022, we performed bibliometric and network visualization analyses to examine publication trends, geographical distribution, institutional collaborations, journal metrics, citation patterns, author contributions, co-citation networks, and keyword co-occurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three distinct phases were identified: foundational (2001–2010), developmental (2011–2018), and accelerated (2019–2024). The United States exhibited the highest citation impact, whereas China reported the highest number of publications. The journals “neurology” and “stroke” emerged as the leading publications. Four major research clusters were revealed: pathophysiological mechanisms (neuroinflammation and oxidative stress), neuroimaging biomarkers (white matter hyperintensities (WMH) and cerebral micro bleeds), clinical manifestations and cognitive assessment, and therapeutic interventions. Emerging trends included blood-brain barrier (BBB) dysfunction, neurovascular coupling, and innovative therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This bibliometric study sheds light on the research hotspots and trends in CSVD-CI over the past two decades, assisting researchers in identifying key focus areas and exploring advancements in this domain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel-Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil
<div> <section> <h3> Background</h3> <p>Chronic stress is a major risk factor for psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder. Chronic stress can cause structural alterations like grey matter atrophy in key emotion-related areas such as the prefrontal cortex (PFC). To identify biological pathways affected by chronic stress in the PFC, researchers have performed transcriptional profiling (RNA sequencing, microarray) to measure gene expression in rodent models. However, transcriptional signatures in the PFC that are shared across different chronic stress paradigms and laboratories remain relatively unexplored.</p> </section> <section> <h3> Methods</h3> <p>We performed a meta-analysis of publicly available transcriptional profiling datasets within the <i>Gemma</i> database. We identified six datasets that characterized the effects of either chronic social defeat stress (CSDS) or chronic variable stress and/or chronic unpredictable mild stress (CUMS) on gene expression in the PFC in mice (<i>n </i>= 117). We fit a random effects meta-analysis model to the chronic stress effect sizes (log(2) fold changes) for each transcript (<i>n </i>= 21,379) measured in most datasets. We then compared our results with two other published chronic stress meta-analyses, as well as transcriptional signatures associated with psychiatric disorders.</p> </section> <section> <h3> Results</h3> <p>We identified 133 genes that were consistently differentially expressed across chronic stress studies and paradigms (false discovery rate [FDR] < 0.05). Fast gene set enrichment analysis (fGSEA) revealed 53 gene sets enriched with differential expression (FDR < 0.05), dominated by glial and neurovascular markers (e.g., oligodendrocyte, astrocyte, endothelial/vascular) and stress-related signatures (e.g., major depressive disorder [MDD], hormonal responses). Immediate-early gene markers of neuronal activity (<i>Fos, Junb, Arc, Dusp1</i>) were consistently suppressed. Many of the identified effects resembled those seen in previous meta-analyses characterizing stress effects (CSDS, early life stress), despite minimal overlap in included samples. Moreover, some effects resembled previous observations from psychiatric disorders, including alcohol abuse disorder, ma, bipolar disorder, and schizophrenia.</p> </section> <section> <h3> Conclusion</h3> <p>Our study demonstrates that chronic stress induces a robust, cross-paradigm PFC signature characterized by downregulation of glia/myelin and vascular pathways and suppression of immediate-ear
{"title":"A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data","authors":"Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel-Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil","doi":"10.1002/brb3.71197","DOIUrl":"10.1002/brb3.71197","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic stress is a major risk factor for psychiatric disorders, including anxiety, depression, and post-traumatic stress disorder. Chronic stress can cause structural alterations like grey matter atrophy in key emotion-related areas such as the prefrontal cortex (PFC). To identify biological pathways affected by chronic stress in the PFC, researchers have performed transcriptional profiling (RNA sequencing, microarray) to measure gene expression in rodent models. However, transcriptional signatures in the PFC that are shared across different chronic stress paradigms and laboratories remain relatively unexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a meta-analysis of publicly available transcriptional profiling datasets within the <i>Gemma</i> database. We identified six datasets that characterized the effects of either chronic social defeat stress (CSDS) or chronic variable stress and/or chronic unpredictable mild stress (CUMS) on gene expression in the PFC in mice (<i>n </i>= 117). We fit a random effects meta-analysis model to the chronic stress effect sizes (log(2) fold changes) for each transcript (<i>n </i>= 21,379) measured in most datasets. We then compared our results with two other published chronic stress meta-analyses, as well as transcriptional signatures associated with psychiatric disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 133 genes that were consistently differentially expressed across chronic stress studies and paradigms (false discovery rate [FDR] < 0.05). Fast gene set enrichment analysis (fGSEA) revealed 53 gene sets enriched with differential expression (FDR < 0.05), dominated by glial and neurovascular markers (e.g., oligodendrocyte, astrocyte, endothelial/vascular) and stress-related signatures (e.g., major depressive disorder [MDD], hormonal responses). Immediate-early gene markers of neuronal activity (<i>Fos, Junb, Arc, Dusp1</i>) were consistently suppressed. Many of the identified effects resembled those seen in previous meta-analyses characterizing stress effects (CSDS, early life stress), despite minimal overlap in included samples. Moreover, some effects resembled previous observations from psychiatric disorders, including alcohol abuse disorder, ma, bipolar disorder, and schizophrenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study demonstrates that chronic stress induces a robust, cross-paradigm PFC signature characterized by downregulation of glia/myelin and vascular pathways and suppression of immediate-ear","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Postoperative delirium (POD) remains challenging to predict in elderly hip fracture patients. This study posited that a newly developed electroencephalogram-derived metric, termed the Delirium Index (DELi), has the potential to elucidate latent information pertaining to the preoperative predisposing factors of POD.
Methods
A prospective cohort of 144 elderly patients undergoing hip fracture surgery was enrolled. DELi scores were derived from preoperative electroencephalography (EEG) using wavelet analysis. POD was diagnosed using the Confusion Assessment Method (CAM). Predictive performance was evaluated via ROC analysis, logistic regression, and bootstrapping validation.
Results
DELi demonstrated strong correlation with CAM scores (r = 0.516, p < 0.0001) and good predictive accuracy for POD (AUC = 0.791, 95% CI: 0.715–0.867). A composite model integrating DELi, Montreal Cognitive Assessment (MoCA), and FRAIL scores achieved excellent discrimination (AUC = 0.922, 95% CI: 0.878–0.965), with 85.9% sensitivity and 86.3% specificity.
Conclusions
The DELi index, combined with cognitive and frailty assessments, provides a practical tool for preoperative POD risk stratification in elderly hip fracture patients.
{"title":"EEG-Derived Index Predicts Postoperative Delirium in Elderly Patients With Hip Fracture: A Prospective Study From a Tertiary Medical Center","authors":"Ayixia Nawan, Geng Wang","doi":"10.1002/brb3.71218","DOIUrl":"10.1002/brb3.71218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Postoperative delirium (POD) remains challenging to predict in elderly hip fracture patients. This study posited that a newly developed electroencephalogram-derived metric, termed the Delirium Index (DELi), has the potential to elucidate latent information pertaining to the preoperative predisposing factors of POD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective cohort of 144 elderly patients undergoing hip fracture surgery was enrolled. DELi scores were derived from preoperative electroencephalography (EEG) using wavelet analysis. POD was diagnosed using the Confusion Assessment Method (CAM). Predictive performance was evaluated via ROC analysis, logistic regression, and bootstrapping validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DELi demonstrated strong correlation with CAM scores (<i>r</i> = 0.516, <i>p</i> < 0.0001) and good predictive accuracy for POD (AUC = 0.791, 95% CI: 0.715–0.867). A composite model integrating DELi, Montreal Cognitive Assessment (MoCA), and FRAIL scores achieved excellent discrimination (AUC = 0.922, 95% CI: 0.878–0.965), with 85.9% sensitivity and 86.3% specificity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DELi index, combined with cognitive and frailty assessments, provides a practical tool for preoperative POD risk stratification in elderly hip fracture patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ChiCTR2200060389</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurses are key to the early detection of autism spectrum disorder (ASD). However, gaps in the literature and misconceptions can delay care; evidence of this from Saudi Arabia is limited. This study was done to examine nurses’ understanding of autism within the Saudi context, inform targeted educational programs, enhance clinical practice, and contribute to closing the persistent global gaps in nurses’ knowledge of ASD.
Methods:
In this study, we employed a cross-sectional online survey of 180 registered nurses to assess their ASD knowledge and beliefs with the aid of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) based criteria and a modified Autism Survey. Moreover, we applied descriptive statistics, chi-square tests with Cramér's V, and Pearson's correlations.
Findings:
Most nurses identified core characteristics, such as lack of eye contact (79.7%), social unresponsiveness (79.7%), and interaction difficulties (79.1%); fewer identified symptom onset before 36 months (53.8%). Misconceptions included “cold parenting” (33.7%), association with intellectual disability (26.7%), and belief that ASD can be outgrown (46.1%). The nurses’ endorsement of intervention for speech therapy (96.7%), special education (94.5%), and parental counseling (87.6%) was the highest; no respondent identified the Applied Behavior Analysis. Correlations between demographics and recognition were weak; prior autism education modestly improved the recognition of unusual mannerisms (r = 0.155, p = 0.037).
Conclusion:
Although the awareness of overt ASD traits is high, limited early onset knowledge, persistence, and evidence-based interventions warrant targeted and culturally informed training.
目的：护士是自闭症谱系障碍（ASD）早期发现的关键。然而，文献上的空白和误解可能会延迟护理；来自沙特阿拉伯的证据有限。本研究旨在检查沙特护士对自闭症的理解，为有针对性的教育计划提供信息，加强临床实践，并有助于缩小护士对自闭症知识的持续全球差距。方法：本研究采用基于第四版《精神障碍诊断与统计手册》（DSM-IV-TR）标准和修改后的《自闭症调查》，对180名注册护士进行横断面在线调查，评估其ASD知识和信念。此外，我们还应用了描述性统计、卡方检验和Pearson相关性。结果：大多数护士确定了核心特征，如缺乏眼神交流（79.7%）、社会反应迟钝（79.7%）和互动困难（79.1%）；36个月前确诊的症状较少（53.8%）。误解包括“冷漠的养育”（33.7%），与智力残疾有关（26.7%），以及认为自闭症可以长大（46.1%）。护士对言语治疗（96.7%）、特殊教育（94.5%）和家长咨询（87.6%）干预的赞同度最高；没有应答者认同应用行为分析。人口统计学与认知之间的相关性较弱；先前的自闭症教育适度提高了对异常行为的识别（r = 0.155, p = 0.037）。结论：尽管对显性ASD特征的认识很高，但有限的早期发病知识、持久性和基于证据的干预措施需要有针对性和文化知情的培训。
{"title":"Understanding Autism through the Eyes of Nurses: a Cross-Sectional Study","authors":"Monirah Albloushi, Reem Saeed Alghamdi, Mona Alqahtani","doi":"10.1002/brb3.71217","DOIUrl":"10.1002/brb3.71217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose:</h3>\u0000 \u0000 <p>Nurses are key to the early detection of autism spectrum disorder (ASD). However, gaps in the literature and misconceptions can delay care; evidence of this from Saudi Arabia is limited. This study was done to examine nurses’ understanding of autism within the Saudi context, inform targeted educational programs, enhance clinical practice, and contribute to closing the persistent global gaps in nurses’ knowledge of ASD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>In this study, we employed a cross-sectional online survey of 180 registered nurses to assess their ASD knowledge and beliefs with the aid of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) based criteria and a modified Autism Survey. Moreover, we applied descriptive statistics, chi-square tests with Cramér's <i>V</i>, and Pearson's correlations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings:</h3>\u0000 \u0000 <p>Most nurses identified core characteristics, such as lack of eye contact (79.7%), social unresponsiveness (79.7%), and interaction difficulties (79.1%); fewer identified symptom onset before 36 months (53.8%). Misconceptions included “cold parenting” (33.7%), association with intellectual disability (26.7%), and belief that ASD can be outgrown (46.1%). The nurses’ endorsement of intervention for speech therapy (96.7%), special education (94.5%), and parental counseling (87.6%) was the highest; no respondent identified the Applied Behavior Analysis. Correlations between demographics and recognition were weak; prior autism education modestly improved the recognition of unusual mannerisms (<i>r</i> = 0.155, <i>p</i> = 0.037).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>Although the awareness of overt ASD traits is high, limited early onset knowledge, persistence, and evidence-based interventions warrant targeted and culturally informed training.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic Obstructive Pulmonary Diseases (COPD) impose a substantial global health burden, yet the joint impact of arterial stiffness and depression on their incidence remains underexplored.
Methods
This cohort study analyzed adults aged ≥45 years from the China Health and Retirement Longitudinal Study (2011–2018). Participants with baseline COPD or missing data were excluded. Cox proportional hazards models assessed associations, while mediation analysis evaluated bidirectional roles of the estimated pulse wave velocity (ePWV) and 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) in new-onset COPD.
Results
Over 7 years, 718 participants developed COPD. ePWV (HR = 1.11, P < 0.0001) and depression (HR = 1.63, P < 0.0001) independently increased risk, with the highest hazard in comorbid cases (HR = 2.17, P < 0.0001). ePWV mediated 1.7% of depression's effect, while depression mediated 4.8% of ePWV's impact (P < 0.05).
Conclusion
Higher ePWV and depressive symptoms were independently associated with incident chronic obstructive pulmonary disease. The observed mediation effects were statistically significant but small in magnitude and should be interpreted as exploratory rather than clinically meaningful. These findings are hypothesis-generating and warrant confirmation using objective measurements and causal study designs.
背景：慢性阻塞性肺疾病（COPD）造成了巨大的全球健康负担，但动脉僵硬和抑郁对其发病率的共同影响仍未得到充分探讨。方法：本队列研究分析了中国健康与退休纵向研究（2011-2018）中年龄≥45岁的成年人。基线COPD或数据缺失的参与者被排除在外。Cox比例风险模型评估了相关性，而中介分析评估了估计脉搏波速度（ePWV）和10项流行病学研究中心抑郁量表（csd -10）在新发COPD中的双向作用。结果：在7年多的时间里，718名参与者患上了COPD。ePWV （HR = 1.11, P < 0.0001）和抑郁（HR = 1.63, P < 0.0001）分别增加了患者的风险，其中合并症患者的风险最高（HR = 2.17, P < 0.0001）。ePWV介导抑郁效应的1.7%，抑郁介导ePWV影响的4.8% （P < 0.05）。结论：高ePWV和抑郁症状与慢性阻塞性肺疾病的发生独立相关。观察到的中介效应具有统计学意义，但幅度较小，应解释为探索性而非临床意义。这些发现是假设的产生和保证确认使用客观测量和因果研究设计。
{"title":"Joint Association of Arterial Stiffness and Depression With New-Onset Self-Reported Chronic Obstructive Pulmonary Disease Among Elderly Chinese Population","authors":"Qinqin Shen, Xingyun Zhu, Yu-Jun Xiong, Tianshui Li, Tian Lv, Hongxia Wang","doi":"10.1002/brb3.71200","DOIUrl":"10.1002/brb3.71200","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic Obstructive Pulmonary Diseases (COPD) impose a substantial global health burden, yet the joint impact of arterial stiffness and depression on their incidence remains underexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study analyzed adults aged ≥45 years from the China Health and Retirement Longitudinal Study (2011–2018). Participants with baseline COPD or missing data were excluded. Cox proportional hazards models assessed associations, while mediation analysis evaluated bidirectional roles of the estimated pulse wave velocity (ePWV) and 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) in new-onset COPD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over 7 years, 718 participants developed COPD. ePWV (HR = 1.11, <i>P</i> < 0.0001) and depression (HR = 1.63, <i>P</i> < 0.0001) independently increased risk, with the highest hazard in comorbid cases (HR = 2.17, <i>P</i> < 0.0001). ePWV mediated 1.7% of depression's effect, while depression mediated 4.8% of ePWV's impact (<i>P</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher ePWV and depressive symptoms were independently associated with incident chronic obstructive pulmonary disease. The observed mediation effects were statistically significant but small in magnitude and should be interpreted as exploratory rather than clinically meaningful. These findings are hypothesis-generating and warrant confirmation using objective measurements and causal study designs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号