Brain and Behavior最新文献_第6页

The Relationship between Type D Personality and Depression Symptoms in Stroke Patients: The Chain Mediating Effect of Self-Efficacy and Participation Preferences D型人格与脑卒中患者抑郁症状的关系：自我效能感和参与偏好的链式中介作用

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71209

Huipin Zhang, Suying Yu, Yun Ye

Background

Stroke significantly impacts population health, and post-stroke depressive symptoms are highly prevalent. Although depression symptoms are linked to Type D personality, self-efficacy, and participation preferences in discharge planning, the mechanisms underlying these interactions remain unclear. This study aimed to examine the chain mediation effects of self-efficacy and discharge planning participation preferences on the relationship between Type D personality and depression symptoms in stroke patients.

Methods

This study used a convenience sampling method to recruit 318 stroke patients from the Department of Neurology at the First People's Hospital of Changzhou. Participants were assessed using the Type D personality scale (DS14), stroke self-efficacy questionnaire (SSEQ), patient participation preferences assessment (PPPA), and self-rating depression scale (SDS). Statistical analyses included descriptive analysis, Spearman's rank correlation analysis, and chain mediation analysis; these analyses were performed using SPSS 25.0 and PROCESS v3.5 (Model 6).

Results

A total of 311 stroke patients were included in this study. Type D personality, self-efficacy, participation preferences, and depression symptoms are significantly correlated with each other (all P < 0.001). Self-efficacy and participation preferences acted as significant mediators between Type D personality and depression symptoms. The total indirect effect accounted for 46.51% of the total effect, and the chain pathway contributed 7.23% (chain indirect effect = 0.030, 95% CI 0.014–0.050).

Conclusion

Type D personality indirectly influences depression symptoms through the chain mediation effects of self-efficacy and participation preferences in stroke patients. This study demonstrates the intrinsic mechanisms by which Type D personality contributes to depression symptoms, providing insights for healthcare professionals to prevent and clinically intervene in stroke patients with depression.

背景：卒中显著影响人群健康，卒中后抑郁症状非常普遍。尽管抑郁症状与D型人格、自我效能和出院计划中的参与偏好有关，但这些相互作用的机制尚不清楚。本研究旨在探讨自我效能感和出院计划参与偏好在脑卒中患者D型人格与抑郁症状关系中的链式中介作用。方法：本研究采用方便抽样方法，选取常州市第一人民医院神经内科318例脑卒中患者。采用D型人格量表（DS14）、卒中自我效能问卷（SSEQ）、患者参与偏好评估（PPPA）和抑郁自评量表（SDS）对参与者进行评估。统计分析包括描述性分析、Spearman秩相关分析和链式中介分析；使用SPSS 25.0和PROCESS v3.5进行分析（模型6）。结果：共纳入311例脑卒中患者。D型人格、自我效能感、参与偏好和抑郁症状之间存在显著相关（均P < 0.001）。自我效能感和参与偏好在D型人格与抑郁症状之间起显著中介作用。总间接效应占总效应的46.51%，链式途径占7.23%（链式间接效应= 0.030,95% CI 0.014 ~ 0.050）。结论：D型人格通过自我效能感和参与偏好的链式中介效应间接影响脑卒中患者抑郁症状。本研究揭示了D型人格影响抑郁症状的内在机制，为卒中合并抑郁患者的预防和临床干预提供了参考。

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引用次数: 0

Uncovering Heterogeneity in the Measurement of Psychological Well-Being in Non-Western Culture: A Latent Profile Analysis of Ghanaian Undergraduates 揭示非西方文化心理幸福感测量的异质性：加纳大学生的潜在剖面分析。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71216

Daniel William Essel, Frank Quansah, Simon Ntumi, Frank Henry Bonsi, Lawrence Sakyi Larbi, Abdul-Razak Ishaaq

Purpose

Psychological well-being among university students is often examined using variable-centered approaches that assume population homogeneity. Using Ryff's eudaimonic model and a person-centered analytic framework, this study examined latent profiles of psychological well-being among Ghanaian undergraduates, offering insight into how the Western-derived model functions in a non-Western cultural context.

Methods

A cross-sectional design was employed to sample 574 regular undergraduate students from a public university in Ghana. Students completed the 18-item Ryff's Psychological Well-Being Scale. Latent profile analysis (LPA) followed by Chi-square tests were performed using JAMOVI statistical software.

Findings

Four distinct profiles emerged: fully flourishing students (38.7%), harmonious life seekers (45.1%), purposeful self-actualizers (7.5%), and aspiring actualizers (8.7%). The profiles differed primarily in levels of autonomy, personal growth, and environmental mastery. Well-being profile membership was not associated with gender but varied significantly by age, although the effect size was small.

Conclusions

The study findings suggest meaningful heterogeneity in eudaimonic well-being among Ghanaian undergraduates and highlight the importance of culturally sensitive, profile-based mental health interventions beyond demographic assumptions.

目的：大学生的心理健康状况通常采用假设人口同质性的以变量为中心的方法进行检查。利用Ryff的幸福模型和以人为中心的分析框架，本研究考察了加纳大学生心理健康的潜在特征，并深入了解了西方衍生模型在非西方文化背景下的作用。方法：采用横断面设计对加纳一所公立大学的574名普通本科生进行抽样调查。学生们完成了包括18个项目的瑞夫心理健康量表。使用JAMOVI统计软件进行潜型分析（LPA）和卡方检验。研究结果：出现了四种不同的类型：全面发展的学生（38.7%），和谐生活的寻求者（45.1%），有目的的自我实现者（7.5%）和有抱负的实现者（8.7%）。这些档案的差异主要体现在自主性、个人成长和对环境的掌控程度上。幸福感档案成员与性别无关，但随年龄变化显著，尽管效应量很小。结论：研究结果表明，加纳大学生的幸福感存在显著的异质性，并强调了超越人口统计学假设的文化敏感性、基于个人概况的心理健康干预的重要性。

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引用次数: 0

Differences in Oxytocin Response Between a Group of Friends and a Group of Strangers Following Facilitated Drum Circle Activities 一群朋友和一群陌生人在鼓点圈活动后催产素反应的差异。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71183

Mitsuru Kikuchi, Sanae Tanaka, Kazumi Furuhara, Haruhiro Higashida, Chiharu Tsuji

Background

Participation in arts-related activities has been shown to positively influence the well-being and social connectedness of young people. However, few studies have explored the neuroendocrinological changes that might contribute to these benefits. In this exploratory study, we assessed oxytocin (OT) and cortisol (CORT) responses in children experiencing facilitated drum circle activities for the first time. These activities involve imitation and coordinated movement, which are known to increase OT levels. Additionally, OT levels are associated with behavioral synchrony and affiliative behaviors in close preexisting relationships, with higher baseline levels observed in individuals who exhibit more affectionate and coordinated interactions. We hypothesized that children participating in facilitated drum circles with their friends would show higher levels of OT than those participating with strangers.

Methods

Elementary school girls were assigned to either a friends group (F-group) or a strangers group (S-group). Salivary samples were collected before and after the facilitated drum circle activities.

Results

Salivary OT increased after the activity in the F-group but not in the S-group. Salivary CORT showed no statistical difference between or within groups.

Conclusion

Our current data suggest that participation in facilitated drum circles with friends may lead to an increase in OT levels in children, and that preexisting bonds may influence the neuroendocrinological response.

背景：参与与艺术有关的活动已被证明对青年人的福祉和社会联系产生积极影响。然而，很少有研究探索可能有助于这些益处的神经内分泌变化。在这项探索性研究中，我们评估了儿童第一次体验促进鼓圈活动时催产素（OT）和皮质醇（CORT）的反应。这些活动包括模仿和协调运动，已知这些活动会增加OT水平。此外，在亲密的既存关系中，OT水平与行为同步性和附属行为有关，在表现出更亲和和协调的互动的个体中观察到更高的基线水平。我们假设，与朋友一起参加鼓圈活动的孩子比与陌生人一起参加的孩子表现出更高的OT水平。方法：将小学女生分为朋友组（f组）和陌生人组（s组）。在辅助鼓圈活动前后采集唾液样本。结果：活动后f组唾液OT升高，s组无明显变化。各组间或组内唾液皮质醇水平无统计学差异。结论：我们目前的数据表明，与朋友一起参与促进鼓圈可能会导致儿童OT水平增加，并且先前存在的联系可能会影响神经内分泌反应。

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引用次数: 0

Probing the Influence of Paternal Diet on Offspring Neuroanatomy With Mouse MRI 用小鼠MRI探讨父系饮食对子代神经解剖学的影响。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71195

Emma G. W. McKnight, Gail Lee, Cheryl Chong, Jane A. Foster, Tie-yuan Zhang, Jason P. Lerch, Brian J. Nieman, Mark R. Palmert

Purpose

Previous studies have established that parental consumption of a diet high in fat and simple sugar (HF/HSS) leads to long-term effects on offspring brain development. However, most studies have focused on the effects of maternal diets or the combined effects of both parents’ diets. As literature suggests that fathers’ environmental factors can also impact offspring brain development, we aimed to explore the impact of isolated paternal consumption of an HF/HSS diet on offspring brain structure.

Methods

C57Bl/6J male mice were acclimated to an HF/HSS diet for eight weeks prior to mating with females who consumed standard chow (control diet, CD). A matching paternal control group was fed the CD during the acclimation period. Throughout gestation and lactation all dams and offspring were fed the CD; all pups were weaned at postnatal day 21 (P21) and stayed on the CD. At P42 offspring brains were prepared for ex vivo magnetic resonance imaging (MRI). Brain MR images were then segmented for volumetric structural analysis.

Results

HF/HSS-fed sires gained more weight during acclimation than CD sires (p < 0.001). However, offspring weights at weaning (P21) and at endpoint (P42) were not significantly affected by paternal diet. Offspring brain morphology, as assessed by volume measurements of 185 brain structures, was not significantly affected by sire HF/HSS diet alone.

Conclusion

While small structural changes cannot be ruled out, the results suggest that previously observed changes in offspring brain structure attributed to parental consumption of HF/HSS diet (selected to mimic some aspects of the human “Western Diet”) require maternal consumption.

目的：以前的研究已经证实，父母摄入高脂肪和单糖的饮食（HF/HSS）会对后代的大脑发育产生长期影响。然而，大多数研究集中在母亲饮食的影响或父母双方饮食的综合影响上。由于文献表明父亲的环境因素也会影响后代的大脑发育，我们旨在探讨孤立的父亲食用HF/HSS饮食对后代大脑结构的影响。方法：C57Bl/6J雄性小鼠在与食用标准饲料（对照饲料，CD）的雌性小鼠交配前，先适应HF/HSS饮食8周。配型父本对照组在驯化期饲喂CD。在整个妊娠期和哺乳期，所有母鼠和子鼠均饲喂CD；所有幼犬在出生后第21天（P21）断奶并停留在CD上。在P42时，准备幼犬的大脑进行离体磁共振成像（MRI）。然后对脑MR图像进行分割以进行体积结构分析。结果：HF/ hss喂养的母猪在驯化过程中体重增加多于CD喂养的母猪（p < 0.001）。然而，断奶时（P21）和终点时（P42）的后代体重没有受到父亲饮食的显著影响。通过对185个脑结构的体积测量来评估后代的脑形态，父辈单独饲喂HF/HSS饲料对后代脑形态没有显著影响。结论：虽然不能排除小的结构变化，但结果表明，先前观察到的由于父母食用HF/HSS饮食（选择模仿人类“西方饮食”的某些方面）而导致的后代大脑结构变化需要母亲食用。

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引用次数: 0

Neural Heterogeneity Underlying Behavioral Equivalence: A Dynamic Neuro-Decoding Study of Cognitive and Affective Empathy in Relation to Autism-Like Traits 行为对等背后的神经异质性：认知和情感共情与自闭症样特征的动态神经解码研究。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71236

Lingyu Zhao, Yixin Jiang, Ziwei Chen, Yongning Song

Purpose

Although empathy processing varies significantly between individuals with high and low autism-like traits (ALT), the underlying neural mechanisms remain poorly understood. This study integrated behavioral measures with electroencephalography (EEG) analyses to investigate neural processing differences between high- and low-ALT groups during cognitive and affective empathy tasks.

Method

We assessed cognitive empathy (judging depicted emotions) and affective empathy (rating personal emotional resonance) in 40 participants (21 high-ALT and 19 low-ALT) using the Multifaceted Empathy Test while concurrently recording EEG data. Our analytical approach combined traditional behavioral analysis with multivariate pattern analysis and representational similarity analysis.

Results

Behaviorally, the groups showed no significant performance differences. However, their neural mechanisms diverged. During cognitive empathy, the high-ALT group exhibited inefficient early sensory processing and delayed, discontinuous neural encoding of emotion categories, suggesting reliance on late-stage compensatory processing. For affective empathy, while early automatic neural resonance was intact, the high-ALT group exhibited atypically sustained reliance on low-level sensory features and failed to form stable, integrated neural representations of emotion, unlike the low-ALT group.

Conclusion

These findings reveal a pattern of “behavioral equivalence, neural heterogeneity.” High-ALT individuals appear to employ distinct, compensatory neural strategies to achieve typical behavioral outcomes in empathy. This highlights the value of advanced neuro-decoding in uncovering latent processing differences underlying the ALT spectrum.

目的：虽然高、低自闭症样特质个体的共情加工存在显著差异，但其潜在的神经机制尚不清楚。本研究将行为测量与脑电图分析相结合，探讨高、低alt组在认知和情感共情任务中的神经加工差异。方法：采用多面共情测试（Multifaceted empathy Test）对40名被试（21名alt高，19名alt低）进行认知共情（判断描述的情绪）和情感共情（评价个人情绪共鸣）评估，同时记录脑电图数据。我们的分析方法将传统的行为分析与多元模式分析和表征相似性分析相结合。结果：两组在行为上无明显差异。然而，他们的神经机制不同。在认知共情过程中，高alt组表现出早期感觉加工效率低下，情绪类别的神经编码延迟、不连续，表明依赖于后期代偿加工。对于情感共情，虽然早期自动神经共振完好无损，但与低alt组不同，高alt组表现出对低水平感觉特征的非典型持续依赖，未能形成稳定、整合的情绪神经表征。结论：这些发现揭示了一种“行为对等，神经异质性”的模式。高alt个体似乎采用独特的代偿性神经策略来实现移情的典型行为结果。这突出了高级神经解码在揭示ALT谱潜在处理差异方面的价值。

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引用次数: 0

Involvement of Adenosine A2A Receptors in Anxiety-Like Behaviors in Tetrahydrocannabinol-Treated Mice 腺苷A2A受体参与四氢大麻酚处理小鼠的焦虑样行为。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71126

Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü, Nermin Seda Ilgaz, Mehmet Bertan Yılmaz, Deniz Seçilmiş, Mehmet Ata Seçilmiş

Background

Previous studies have suggested that adenosinergic system in the central nervous system may play a role in both behavioral changes and the physiopathology induced by Δ⁹-tetrahydrocannabinol (THC), and this is thought to be mediated by adenosine A₂A receptors (A₂ARs). However, the contribution of the adenosinergic system to the anxiety-like behaviors in response to THC in mice is not well understood.

Aims

In this study, we aimed to investigate the possible role of the adenosinergic system in THC-treated mice.

Methods

For that purpose, we combined behavioral tests and molecular analyses to investigate the effects of THC in relation with the agonist and antagonist of the adenosinergic system, CGS-21680 (CGS) and istradefylline, respectively, on both anxiety-like behaviors and hippocampal gene expression.

Results

The results demonstrated that THC induced anxiety-like behavior, and gene expression patterns indicated a significant interaction between the adenosinergic and cannabinoidergic systems. Notably, the data suggest that THC plays a predominant role in this molecular interplay, with its effects being partially modulated by changes in the expression of both cannabinoidergic and adenosinergic receptors, CB₁R and A₂AR, respectively.

Conclusion

These findings contribute to the understanding of THC's complex pharmacological actions, highlighting the importance of receptor cross talk in modulating anxiety and other behavioral outcomes.

背景：既往研究表明，中枢神经系统腺苷能系统可能在Δ9-tetrahydrocannabinol （THC）诱导的行为改变和生理病理中发挥作用，并认为这是由腺苷A2A受体（A2ARs）介导的。然而，腺苷能系统对小鼠对四氢大麻酚反应的焦虑样行为的贡献尚不清楚。目的：在本研究中，我们旨在探讨腺苷能系统在四氢大麻酚处理小鼠中的可能作用。方法：采用行为学实验和分子分析相结合的方法，研究四氢大麻酚与腺苷能系统激动剂和拮抗剂CGS-21680 （CGS）和伊斯特福碱分别对焦虑样行为和海马基因表达的影响。结果：结果表明四氢大麻酚诱导焦虑样行为，基因表达模式表明腺苷能和大麻素能系统之间存在显著的相互作用。值得注意的是，数据表明THC在这种分子相互作用中起主导作用，其作用分别由大麻素能受体和腺苷能受体CB1R和A2AR的表达变化部分调节。结论：这些发现有助于理解四氢大麻酚的复杂药理作用，突出了受体串扰在调节焦虑和其他行为结果中的重要性。

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引用次数: 0

Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models 在抑郁模型中，脂多糖上调神经炎症、氧化应激反应和过氧化物还毒素。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71231

Zhifang Zhang, Nanshi Li, Mingkun Liang, Fangyan Qin, Qijing Qin, Qing He, Kaihua Wang, Xueli Shi, Ying Jiang, Hui Qin

Introduction

Depression is a chronic psychiatric disorder and belongs to one of the leading causes of suicide worldwide. Peroxiredoxins (Prdxs) play a critical role in scavenging excess reactive oxygen species (ROS) and mitigating oxidative stress. However, the role and underlying mechanisms of Prdxs in depression have not been fully illustrated.

Methods

We carried out lipopolysaccharide (LPS)-induced ICR depression mice and BV2 cell inflammation models. Seven days after LPS-induction, behaviors in ICR mice were assessed by open field test (OFT), sucrose preference test (SPT), and forced swim test (FST), and inflammatory factors levels in serum were quantified via ELISA. The expression levels of Prdxs were evaluated using immunohistochemistry (IHC), western blotting (WB), and RT-qPCR. In LPS-induced BV2 cells, inflammatory factor levels in the supernatant were measured by ELISA. Nitric oxide (NO) levels were detected by biochemical assay. ROS levels were detected via fluorescence signal intensity. Prdxs expression levels were analyzed using WB and RT-qPCR.

Results

In LPS-induced ICR mice serum and BV2 cells supernatant, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-beta1 (TGF-β1) levels exhibited significant elevation (p < 0.05). In the hippocampus region of LPS-induced mice and LPS-induced BV2 cells, significant upregulation of Prdx1, Prdx2, Prdx4, and Prdx5 levels was observed (p < 0.05). The ROS and NO levels in LPS-induced BV2 cells also significantly increased (p < 0.05).

Conclusions

This study revealed that Prdx1, Prdx2, Prdx4, and Prdx5 were elevated in depression models, which might relate to the occurrence of neuroinflammation, coupled with upregulation of oxidative stress responses. This study provided new strategies for the treatment of depression.

抑郁症是一种慢性精神疾病，是世界范围内自杀的主要原因之一。过氧化物还毒素（Prdxs）在清除过量活性氧（ROS）和减轻氧化应激中起着关键作用。然而，Prdxs在抑郁症中的作用和潜在机制尚未得到充分阐明。方法：采用脂多糖（LPS）诱导的ICR抑制小鼠和BV2细胞炎症模型。lps诱导7 d后，采用开放场试验（OFT）、蔗糖偏好试验（SPT）和强迫游泳试验（FST）评估ICR小鼠的行为，ELISA法测定血清炎症因子水平。采用免疫组织化学（IHC）、western blotting （WB）和RT-qPCR检测Prdxs的表达水平。在lps诱导的BV2细胞中，用ELISA法检测上清液中的炎症因子水平。采用生化法检测一氧化氮（NO）水平。通过荧光信号强度检测ROS水平。采用WB和RT-qPCR分析Prdxs的表达水平。结果：lps诱导的ICR小鼠血清和BV2细胞上清中，白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)、转化生长因子-β1 （TGF-β1）水平显著升高(p)。结论：本研究揭示抑郁模型中Prdx1、Prdx2、Prdx4、Prdx5水平升高，可能与神经炎症的发生有关，并伴有氧化应激反应的上调。本研究为抑郁症的治疗提供了新的策略。

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引用次数: 0

Difficulties in Emotion Regulation Mediate the Association Between Peer Attachment and Problematic Use of Smartphone 情绪调节困难在同伴依恋与智能手机问题使用之间的中介作用

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71224

Zi-Liang Wang, Yan-Li Zhang

Background

Problematic use of smartphone (PUS) is increasingly prevalent among adolescents and may be influenced by both peer relationships and emotion-regulation capacities. This study tested whether difficulties in emotion regulation mediate the association between peer attachment and PUS, and whether these pathways differ by gender, age, and school type.

Methods:

A cross-sectional survey recruited 12,099 Chinese adolescents (mean age = 18.93 years, 58% female) through stratified cluster sampling. Participants completed validated measures of PUS, peer attachment, and the Difficulties in Emotion Regulation Scale (DERS). Structural equation modeling (SEM) examined mediation via a latent DERS factor, controlling for demographics. Multi-group SEM evaluated moderation across gender, age (> 18 vs. ≤ 18), and school (university vs. high school).

Results

Peer attachment was negatively associated with emotion-regulation difficulties (β = −0.296, p < 0.001) and with PUS (β = −0.144, p < 0.001). Emotion-regulation difficulties positively predicted PUS (β = 0.372, p < 0.001). The indirect effect (β = −0.110, 95% CI [−0.116, −0.104]) confirmed partial mediation. Multi-group SEM indicated significant moderation (Δχ² = 76.01–93.70, all p < 0.001): the effect of emotion-regulation difficulties on PUS was stronger among females; the impact of weaker peer attachment on emotion regulation was stronger among younger adolescents; and school type moderated both the path and the direct effect on PUS. Nevertheless, the mediation pathway remained significant in all subgroups.

Conclusions

Emotion-regulation difficulties partially explain the link between peer attachment and PUS in adolescents. The strength of these pathways varies by gender, age, and school context, highlighting emotion regulation as a promising intervention target.

智能手机的问题使用（PUS）在青少年中越来越普遍，可能受到同伴关系和情绪调节能力的影响。本研究测试了情绪调节困难是否介导同伴依恋与PUS之间的关联，以及这些途径是否因性别、年龄和学校类型而异。

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引用次数: 0

Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats Rhein抑制脑出血大鼠NLRP3活化及减轻小胶质细胞焦亡。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71230

Adalaiti Aimaiti, Qian Li, Tao Liu, Chen Chen, Xiaolin Xie, Jianshu Chu, Dilihumaer Nuermaimaiti, Yan Hu

Background

Intracerebral hemorrhage (ICH) induces severe neuroinflammation and microglial pyroptosis, exacerbating secondary brain injury. Rhein, a natural anthraquinone compound, possesses anti-inflammatory and neuroprotective properties. However, its effects on microglial pyroptosis and the underlying mechanisms remain unclear.

Methods

A rat microglial (RM) pyroptosis model was established using LPS + ATP induction, followed by rhein intervention and NLRP3 knockdown. Cell proliferation was assessed using CCK-8, and apoptosis was evaluated through TUNEL staining. ELISA was used to measure the expression levels of inflammatory cytokine. Immunofluorescence staining was performed to label M1/M2 microglia. RT-qPCR and western blot were used to analyze the expression of NLRP3, ASC, Caspase-1, GSDMD, PCNA, Cyclin D1, and CDK2. Transmission electron microscopy (TEM) was used to observe pyroptotic bodies. Additionally, a rat ICH model was established, with rhein intervention and NLRP3 knockdown/Caspase-1 inhibition. Behavioral assessments were conducted using the Y-maze test and open-field test. HE staining was performed to examine brain tissue pathology. ELISA was used to measure inflammatory cytokine levels in brain tissue. Immunofluorescence staining analyzed the distribution of M1/M2 microglia. RT-qPCR and western blot were used to detect pyroptosis-related proteins, and TEM was used to evaluate pyroptotic body formation.

Results

At the cellular level, rhein significantly promoted microglial proliferation and M2 polarization while inhibiting pyroptosis, inflammatory cytokine expression, M1 polarization, and NLRP3 expression. NLRP3 knockdown further enhanced the protective effects of rhein. At the animal level, ICH model rats exhibited reduced exploratory behavior, exacerbated neuroinflammation, increased pro-inflammatory cytokine expression, increased M1 microglia, and elevated NLRP3 expression and pyroptosis levels. Rhein intervention significantly alleviated inflammation in ICH rats by reducing the expression of NLRP3 and pyroptosis-related proteins. NLRP3 knockdown or Caspase-1 inhibition further enhanced rhein's protective effects.

Conclusion

Rhein alleviates neurological dysfunction following ICH by inhibiting NLRP3 inflammasome activation, reducing microglial pyroptosis, and mitigating neuroinflammation.

背景：脑出血可引起严重的神经炎症和小胶质细胞焦亡，加重继发性脑损伤。莱茵是一种天然的蒽醌类化合物，具有抗炎和神经保护作用。然而，其对小胶质细胞焦亡的影响及其潜在机制尚不清楚。方法：采用LPS + ATP诱导大鼠小胶质细胞（RM）焦亡模型，大黄酸干预并下调NLRP3。CCK-8检测细胞增殖，TUNEL染色检测细胞凋亡。ELISA法检测炎症细胞因子的表达水平。免疫荧光染色标记M1/M2小胶质细胞。RT-qPCR和western blot检测NLRP3、ASC、Caspase-1、GSDMD、PCNA、Cyclin D1、CDK2的表达。用透射电镜（TEM）观察热腐体。此外，建立了大鼠脑出血模型，大黄酸干预和NLRP3敲低/Caspase-1抑制。行为学评价采用y形迷宫试验和空地试验。HE染色检查脑组织病理。ELISA法检测脑组织炎症细胞因子水平。免疫荧光染色分析M1/M2小胶质细胞的分布。RT-qPCR和western blot检测热腐相关蛋白，TEM检测热腐体形成。结果：在细胞水平上，大黄酸显著促进小胶质细胞增殖和M2极化，抑制焦亡、炎症细胞因子表达、M1极化和NLRP3表达。NLRP3敲低进一步增强了大黄酸的保护作用。在动物水平上，ICH模型大鼠探索性行为减少，神经炎症加重，促炎细胞因子表达增加，M1小胶质细胞增加，NLRP3表达和焦亡水平升高。Rhein干预通过降低NLRP3和热释相关蛋白的表达，显著减轻ICH大鼠的炎症反应。NLRP3敲低或Caspase-1抑制进一步增强了大黄酸的保护作用。结论：Rhein通过抑制NLRP3炎性小体活化、减少小胶质细胞焦亡、减轻神经炎症，减轻脑出血后神经功能障碍。

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引用次数: 0

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling 神经发生和表观遗传景观：组蛋白修饰和染色质重塑的作用。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-01-28 DOI: 10.1002/brb3.71223

Degisew Yinur Mengistu, Biniam Moges Eskeziyaw

Aims

The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression during embryonic neurogenesis. It aims to highlight the role of these mechanisms in neural stem cell (NSC) fate specification and their implications in neurological and neurodevelopmental disorders.

Methods

Through reviewing recent research findings, this study synthesizes current literature on epigenetic mechanisms involved in embryonic brain development, with a focus on histone modifications, chromatin remodeling, and chromatin compartmentalization. The review also evaluates existing in vivo research while noting the technical challenges of tracking adult neurons and isolating NSCs.

Findings

The review identifies that epigenetic mechanisms, including histone methylation (notably H3K9 as a repressive mark), histone deacetylases, and chromatin remodeling complexes, play essential roles in regulating gene expression required for neurogenesis and neuroplasticity. Alterations in these epigenetic processes significantly affect neural development and contribute to a range of neurological and neurodevelopmental disorders.

Conclusions

Understanding the epigenetic regulation of neurogenesis particularly through chromatin modification and structural chromatin dynamics provides valuable insight into cell fate determination during embryonic brain development. These insights may guide the development of novel therapeutic strategies for neurological and neurodevelopmental disorders.

目的：本综述的目的是研究表观遗传调控，特别是染色质修饰和组蛋白甲基化如何控制胚胎神经发生过程中的基因表达。目的是强调这些机制在神经干细胞（NSC）命运规范中的作用及其在神经和神经发育障碍中的意义。方法：在回顾近年研究成果的基础上，综合目前有关胚胎脑发育的表观遗传机制的文献，重点从组蛋白修饰、染色质重塑和染色质区隔化等方面进行研究。该综述还评估了现有的体内研究，同时指出了跟踪成年神经元和分离NSCs的技术挑战。研究发现，表观遗传机制，包括组蛋白甲基化（特别是H3K9作为抑制标记）、组蛋白去乙酰化酶和染色质重塑复合物，在调节神经发生和神经可塑性所需的基因表达中发挥重要作用。这些表观遗传过程的改变显著影响神经发育，并导致一系列神经和神经发育障碍。结论：理解神经发生的表观遗传调控，特别是通过染色质修饰和结构染色质动力学，为胚胎大脑发育过程中细胞命运的决定提供了有价值的见解。这些见解可能指导神经和神经发育障碍的新治疗策略的发展。

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引用次数: 0