Brain and Behavior最新文献_第7页

Is the Relationship Between Adolescent Social Isolation and Anxiety-Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-09 DOI: 10.1002/brb3.70369

Matthew A. Blumberg, Ava Shipman, Lidia Olyha, Stephen C. Gironda, Jeffrey L. Weiner

Objective

Despite extensive, cross-disciplinary research revealing a relationship between early life stress (ELS) and an increased risk for neuropsychiatric disorders, the underlying processes mediating this relationship are not fully understood. Further, the majority of preclinical studies investigating this relationship have not taken sex differences into consideration. A growing body of work suggests that microglia, resident immune cells of the brain, are impacted by ELS and contribute to some of the maladaptive behavioral phenotypes in adulthood. Here, we utilized an adolescent social isolation (aSI) model of ELS in female rats to test the role of microglia in mediating the effects of ELS on anxiety-related behaviors.

Methods

The present study sought to determine whether microglia ablation during aSI could prevent anxiety-like behaviors in female Long Evans rats. A colony-stimulating factor 1 receptor (CSF1-r) inhibitor, PLX3397, was provided in chow to ablate microglia at the start of the isolation period (postnatal day (P) 21–42). During the aSI period, animals performed a battery of behavioral assays including the open field test, elevated plus maze, and successive alleys test. Following completion of the behavioral assays, brain tissue was collected to confirm the efficacy of PLX3397 and identify changes in microglia population density.

Results

Relative to group-housed (GH) controls, aSI rats showed increased locomotor activity in the open field test and higher closed-arm entries on the elevated plus maze. Although PLX3397 effectively ablated microglia across all animals, this treatment had minimal effects on observed aSI-associated phenotypes.

Conclusions

Together, these data suggest that microglia are not required for behavioral adaptations promoted by aSI. Future studies will be needed to assess the role of microglia in the relationship between ELS and maladaptive behavioral phenotypes.

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引用次数: 0

Activation of SIRT1 by Hydroxysafflor Yellow A Attenuates Chronic Unpredictable Mild Stress-Induced Microglia Activation and Iron Death in Depressed Rats

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-09 DOI: 10.1002/brb3.70385

Jianle He, Min He, Ping Yang, Jianhui Shangguan, Lingxia Jiang, Zhiqiang Liu

Background

Hydroxysafflor yellow A (HSYA), the main active ingredient in safflower, possesses antioxidant and anti-inflammatory activities. We confirmed in our previous study that HSYA exerts antidepressant effects, but further investigation is needed to uncover the exact mechanism. Herein, we aimed to explore the antidepressant effects of HSYA based on microglial activation and ferroptosis studies.

Methods

The chronic unpredictable mild stress (CUMS) procedure was used to establish a depression model in rats. Behavioral tests were conducted on rats after HSYA administration. Iba-1 immunostaining was used to determine the activation of microglia in the hippocampus. We examined the iron ion level using a colorimetric method. Assayed by western blot for protein expression.

Results

Rats receiving HSYA showed enhanced spatial learning and memory abilities, as well as improvements in depression-like behaviors. HSYA administration reduced Iba-1 expression in CUMS rats’ hippocampus, indicating that HSYA suppressed microglial activation. HSYA inhibited CUMS-induced Fe²⁺ concentration and promoted ferroptosis-related protein GPX4 and SLC7A11 expression. HSYA treatment also elevated SIRT1 and Nrf2 protein levels, while p-p65 protein levels decreased in the hippocampus of CUMS rats.

Conclusion

HSYA exerts an antidepressant-like effect by inhibiting microglia activation in the hippocampus and inducing SIRT1/Nrf2/NF-kB signaling.

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引用次数: 0

Sleep Deprivation-Induced Anxiety Alleviated by Oral Administration of 4-Aminopyridine in Male Mice

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-09 DOI: 10.1002/brb3.70382

Ehsan Hosseini

Purpose

Insufficient sleep and insomnia are common issues associated with modern lifestyles that often contribute to the development of mental health disorders. 4-aminopyridine (4-AP), a voltage-gated potassium (Kv) channel antagonist, is commonly used in the treatment of multiple sclerosis (MS). It has been shown to improve nerve conduction velocity, strengthen myelin, and increase axonal area after injury. In addition, 4-AP has been reported to reduce behavioral disorders, including depression. The aim of this study was to investigate the effects of 4-AP on anxiety-like behavior in mice subjected to rapid eye movement (REM) sleep deprivation.

Methods

Fifty male mice were randomly divided into five groups: control, normal saline (NS) (receiving normal saline via gavage), AP-0.25, AP-0.5, and AP-1 (receiving daily doses of 0.25, 0.5, and 1 mg/kg of 4-AP, respectively by gavage). All groups except the control group underwent SD for five consecutive days. The animals' locomotion and anxiety-like behavior were assessed using the open field and elevated plus maze tests. After behavioral testing, N-methyl-D-aspartate receptor (NMDA-R), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R), and tumor necrosis factor (TNF-α) were measured by western blotting, and also malondialdehyde (MDA) and total antioxidant capacity (TAC) were analyzed by ELISA in the hippocampus.

Finding

AP-1 significantly reduced the levels of anxiety-like behavior compared to the NS group in both tests. In AP-1, a significant decrease in the levels of NMDA-R, AMPA-R, TNF-α, and MDA was observed. While these levels were increased in the NS group. In addition, AP-1 showed a higher level of TAC compared to the NS group, indicating an increase in antioxidant levels.

Conclusion

4-AP may be effective in reducing anxiety-like behavior in sleep-deprived mice by modifying the levels of NMDA-R, AMPA-R, and TNF-α, while simultaneously reducing oxidative stress induced by sleep deprivation in the hippocampus.

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引用次数: 0

Application of Genetic Testing for Anorexia Nervosa: An Ethical Analysis

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-09 DOI: 10.1002/brb3.70406

Sarah Ramsay, Kendra Allison, Heide S. Temples, Sara Sarasua, Luigi Boccuto

Objective

Anorexia Nervosa (AN) is a severe, debilitating disorder with a high mortality rate. Research indicates that genetics plays a significant role in AN manifestation and persistence. Genetic testing has the potential to transform how AN is treated, however, in clinical practice, care must be taken to consider the ethical complexities involved. Our objective was to perform an ethical analysis of genetic testing in AN.

Methods

We applied the principlist approach, taking into consideration the stakeholders involved and the core ethical principles of autonomy, beneficence, non-maleficence, and justice to (1) evaluate the possible ethical implications of the use of genetic testing in the treatment of patients with AN, and (2) assess whether such testing is justified and if so, under what conditions.

Results

Potential benefits of genetic testing identified include reduction of misdiagnosis and identification of treatable concurrent genetic conditions. The identified potential risks of genetic testing for possible AN-associated risk variants outside of a research setting, especially without more effective treatment options, include a false sense of reassurance for those testing negative and a reduced emphasis on the importance of behavioral-based therapies that may be of benefit.

Discussion

Genetic testing for complex disorders, including AN, has tremendous potential, but is still primarily research-based. Currently, for those presenting with atypical AN, and severe and enduring AN who, by definition, have not benefited from traditional treatment, genetic testing to rule out or identify other genetic conditions could be of benefit.

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引用次数: 0

Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-09 DOI: 10.1002/brb3.70127

Daniel Lordelo San Martin, Marcos Baruch Portela Filho, Chiara Rocchi, Shahd Hamid, Saif Huda

Background

Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear.

Objective

The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD.

Methods

This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow-up were included. To identify factors associated with relapse location, logistic regression was performed.

Results

An increased risk of a relapse in the same location was observed when the first attack was optic neuritis—for the second attack (OR 12.9, 95% CI 3.31–50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61–18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis—for the second attack (OR 0.25, 95% CI 0.07–0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06–0.96, p = .045).

Conclusion

In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.

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引用次数: 0

Context-Sensitive Conscious Interpretation and Layer-5 Pyramidal Neurons in Multistable Perception

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-04 DOI: 10.1002/brb3.70393

Talis Bachmann

Introduction

There appears to be a fundamental difference between the two ways of how an object becomes perceptually experienced. One occurs when preconscious object-specifying sensory data processing crosses a certain threshold so that sensory constituents of object depiction become consciously experienced. The other occurs when the already consciously experienced sensory features of the object become interpreted as belonging to a certain visual object category. Surprisingly, experimental facts about neural markers of conscious access gathered so far do not allow us to distinguish mechanisms responsible for these two varieties.

Methods

A cortical multicompartment layer-5 pyramidal neuron-based generic processing model is presented in order to conceptualize a possible mechanistic solution for the explanatory cul-de-sac. To support the argument, a review of pertinent research is compiled as associated with data from studies where physically invariant perceptual stimuli have underwent alternative interpretation(s) by the brain.

Results

Recent developments in the newly emerging field of cellular psycho(physio)logy are introduced, offering a hypothetical solution for distinguishing the mechanisms subserving sensory content experience and conscious interpretation.

Conclusion

The multicompartment single cell-based mechanistic approach to brain process correlates of conscious perception appears to have an added value beyond the traditional inter-areal connectivity-based theoretical stances.

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引用次数: 0

Prevalence of Cognitive Impairment/Dementia and Associated Risks Factors Among Community-Dwelling Elderly People Aged 65 or Above in the Community Centers in Hong Kong: A Cross-Sectional Study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-04 DOI: 10.1002/brb3.70388

Irelan Tam, Kailu Wang

Backgrounds

Dementia is a leading cause of morbidity and disability for elderly people worldwide, and prevalence rates of dementia are estimated to be 30% among people ≥80 years old. The burden of the disease could reach 11% of population aged over 60 in 2039.

Objectives

The study aims to report the prevalence rate of cognitive impairment/dementia among community-dwelling elderly people aged ≥65 years old and identify the associated risk factors for dementia prevention.

Methods

This cross-sectional study used non-probability sampling technique. Participants 65 years old were interviewed using a structured questionnaire, and the Cantonese version of Mini-Mental State Examination was used to screen for cognitive impairment/dementia. CMMSE score of ≤20 was the cut-off points. Multivariate logistic regression was performed to examine risk factors associated with cognitive impairment/dementia.

Results

From 241 respondents, the study reported the overall prevalence of cognitive impairment/dementia was 18.9%, ranging between 13% and 33% in different age groups. Depression and those who belonged to lower socioeconomic status receiving Comprehensive Social Security Assistance were found to be significant risk factors for cognitive impairment/dementia.

Conclusion

The study showed higher overall prevalence of cognitive impairment/dementia in the community centers than previous studies and potentially high percentage of elderly with undetected dementia in the community. The finding highlighted the importance of increasing dementia literacy, strengthening health promotion for population-wide screening with follow-up diagnosis to enable early detection and subsequent interventions and treatments to improve the quality of dementia care for elderly in Hong Kong.

{"title":"Prevalence of Cognitive Impairment/Dementia and Associated Risks Factors Among Community-Dwelling Elderly People Aged 65 or Above in the Community Centers in Hong Kong: A Cross-Sectional Study","authors":"Irelan Tam, Kailu Wang","doi":"10.1002/brb3.70388","DOIUrl":"https://doi.org/10.1002/brb3.70388","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Backgrounds</h3>\u0000 \u0000 <p>Dementia is a leading cause of morbidity and disability for elderly people worldwide, and prevalence rates of dementia are estimated to be 30% among people ≥80 years old. The burden of the disease could reach 11% of population aged over 60 in 2039.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The study aims to report the prevalence rate of cognitive impairment/dementia among community-dwelling elderly people aged ≥65 years old and identify the associated risk factors for dementia prevention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study used non-probability sampling technique. Participants 65 years old were interviewed using a structured questionnaire, and the Cantonese version of Mini-Mental State Examination was used to screen for cognitive impairment/dementia. CMMSE score of ≤20 was the cut-off points. Multivariate logistic regression was performed to examine risk factors associated with cognitive impairment/dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 241 respondents, the study reported the overall prevalence of cognitive impairment/dementia was 18.9%, ranging between 13% and 33% in different age groups. Depression and those who belonged to lower socioeconomic status receiving Comprehensive Social Security Assistance were found to be significant risk factors for cognitive impairment/dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study showed higher overall prevalence of cognitive impairment/dementia in the community centers than previous studies and potentially high percentage of elderly with undetected dementia in the community. The finding highlighted the importance of increasing dementia literacy, strengthening health promotion for population-wide screening with follow-up diagnosis to enable early detection and subsequent interventions and treatments to improve the quality of dementia care for elderly in Hong Kong.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in EEG Microstate Dynamics and Cognition Post-Chemotherapy in People With Breast Cancer

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-04 DOI: 10.1002/brb3.70335

S. Damji, S. Sattari, K. Zadravec, K. L. Campbell, J. Brunet, N. Virji-Babul

Objective

Chemotherapy-related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large-scale neural networks remain unclear. Using data from the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, we conducted exploratory analyses to compare self-reported and objective measures of cognition and applied microstate analysis to resting state (RS) electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment.

Methods

Data from eight female participants between the ages of 30 and 52 (mean age = 44.8 years, SD = 7.3 years) were analyzed. Cognitive function was assessed using the PROMIS (Patient-Reported Outcomes Measurement Information System) and the Trail Making Test (TMT). Five minutes of RS eyes-closed EEG data were also collected. Seven EEG microstates were extracted, and mean microstate duration and occurrence were computed.

Results

Following chemotherapy, there was a significant decrease in the PROMIS score (p = 0.003, d = 1.601), but no significant difference in the TMT score. Overall, microstate durations were significantly longer (p < 0.001, d = 2.837) and less evenly distributed following chemotherapy. The mean duration of microstate D (involved in attention/executive functions) significantly increased following chemotherapy (p = 0.007, d = 1.339). Comparing behavioral and microstate measures that exhibited a large effect size, no significant correlations were observed either before or after chemotherapy.

Conclusions

We observed self-reported cognitive impairment and disturbed functional dynamics in the RS brain following chemotherapy. This exploratory study provides new evidence using a within-cohort design showing that changes occur in large scale brain dynamics related to the cognitive effects of chemotherapy.

Trial Registration

ClinicalTrials.gov identifier: NCT03277898

{"title":"Changes in EEG Microstate Dynamics and Cognition Post-Chemotherapy in People With Breast Cancer","authors":"S. Damji, S. Sattari, K. Zadravec, K. L. Campbell, J. Brunet, N. Virji-Babul","doi":"10.1002/brb3.70335","DOIUrl":"https://doi.org/10.1002/brb3.70335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Chemotherapy-related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large-scale neural networks remain unclear. Using data from the <i>Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE)</i> trial, we conducted exploratory analyses to compare self-reported and objective measures of cognition and applied microstate analysis to resting state (RS) electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from eight female participants between the ages of 30 and 52 (mean age = 44.8 years, SD = 7.3 years) were analyzed. Cognitive function was assessed using the PROMIS (Patient-Reported Outcomes Measurement Information System) and the Trail Making Test (TMT). Five minutes of RS eyes-closed EEG data were also collected. Seven EEG microstates were extracted, and mean microstate duration and occurrence were computed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Following chemotherapy, there was a significant decrease in the PROMIS score (<i>p </i>= 0.003, <i>d </i>= 1.601), but no significant difference in the TMT score. Overall, microstate durations were significantly longer (<i>p </i>< 0.001, <i>d </i>= 2.837) and less evenly distributed following chemotherapy. The mean duration of microstate D (involved in attention/executive functions) significantly increased following chemotherapy (<i>p </i>= 0.007, <i>d</i> = 1.339). Comparing behavioral and microstate measures that exhibited a large effect size, no significant correlations were observed either before or after chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We observed self-reported cognitive impairment and disturbed functional dynamics in the RS brain following chemotherapy. This exploratory study provides new evidence using a within-cohort design showing that changes occur in large scale brain dynamics related to the cognitive effects of chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT03277898</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-Sample Bidirectional Mendelian Randomization Study With Causal Association Between Metabolic Syndrome and Cerebral Aneurysm

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-04 DOI: 10.1002/brb3.70396

Yu Li, Kai Zhao

Background

We used a two-sample mendelian randomization (MR) method to comprehensively investigate the causality of metabolic syndrome (MetS) or its components, including MetS, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), waist circumference (WC), and hypertension (HP), with cerebral aneurysm including nonruptured and ruptured aneurysmal subarachnoid hemorrhage (SAH).

Methods

By leveraging large-scale genome-wide association study (GWAS) summary statistics of MetS or its components and cerebral aneurysm (nonruptured and SAH) from European, MR, reverse-direction MR, and sensitivity analysis were utilized to quantify the genetic correlations and causal relationships. In addition, we adjusted for multiple comparisons using the false discovery rate (FDR) correction.

Results

Two-sample MR analysis showed that HP was a risk factor for cerebral aneurysm (nonruptured and SAH) with odds ratio (OR) of 58.959 (95% confidence interval [95% CI] = 12.073–287.920, p < 0.001, q < 0.001), and 32.290 (95% CI = 5.615–185.671, p < 0.001, q < 0.001), respectively. HDL-C (OR = 0.836, 95% CI = 0.728–0.960, p = 0.011, q = 0.039) and FBG (OR = 0.626, 95% CI = 0.426–0.919, p = 0.017, q = 0.039) were negatively correlated with cerebral aneurysm (nonruptured). The HDL-C result was inconsistent after adjusting for TG and LDL-C by multivariable MR analysis. In reverse MR analysis, we found that there was no statistical causal association between cerebral aneurysm (nonruptured) and MetS or its components. Genetic liability to cerebral aneurysm (SAH) was inversely associated with HDL-C and FBG but was not associated with others, however, sensitivity analysis showed that few instrumental variables made a big difference.

Conclusions

Genetically determined elevated FBG level reduces the risk of cerebral aneurysm (nonruptured). However, hypertension increases the risk of cerebral aneurysm (nonruptured and SAH).

{"title":"Two-Sample Bidirectional Mendelian Randomization Study With Causal Association Between Metabolic Syndrome and Cerebral Aneurysm","authors":"Yu Li, Kai Zhao","doi":"10.1002/brb3.70396","DOIUrl":"https://doi.org/10.1002/brb3.70396","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We used a two-sample mendelian randomization (MR) method to comprehensively investigate the causality of metabolic syndrome (MetS) or its components, including MetS, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), waist circumference (WC), and hypertension (HP), with cerebral aneurysm including nonruptured and ruptured aneurysmal subarachnoid hemorrhage (SAH).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>By leveraging large-scale genome-wide association study (GWAS) summary statistics of MetS or its components and cerebral aneurysm (nonruptured and SAH) from European, MR, reverse-direction MR, and sensitivity analysis were utilized to quantify the genetic correlations and causal relationships. In addition, we adjusted for multiple comparisons using the false discovery rate (FDR) correction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two-sample MR analysis showed that HP was a risk factor for cerebral aneurysm (nonruptured and SAH) with odds ratio (OR) of 58.959 (95% confidence interval [95% CI] = 12.073–287.920, <i>p </i>< 0.001, <i>q</i> < 0.001), and 32.290 (95% CI = 5.615–185.671, <i>p </i>< 0.001, <i>q </i>< 0.001), respectively. HDL-C (OR = 0.836, 95% CI = 0.728–0.960, <i>p</i> = 0.011, <i>q</i> = 0.039) and FBG (OR = 0.626, 95% CI = 0.426–0.919, <i>p</i> = 0.017, <i>q</i> = 0.039) were negatively correlated with cerebral aneurysm (nonruptured). The HDL-C result was inconsistent after adjusting for TG and LDL-C by multivariable MR analysis. In reverse MR analysis, we found that there was no statistical causal association between cerebral aneurysm (nonruptured) and MetS or its components. Genetic liability to cerebral aneurysm (SAH) was inversely associated with HDL-C and FBG but was not associated with others, however, sensitivity analysis showed that few instrumental variables made a big difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Genetically determined elevated FBG level reduces the risk of cerebral aneurysm (nonruptured). However, hypertension increases the risk of cerebral aneurysm (nonruptured and SAH).</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta-Analysis of Randomized Clinical Trials

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2025-03-04 DOI: 10.1002/brb3.70401

Atefeh Zandifar, Rahim Badrfam, Mahdi Mohammaditabar, Bita Kargar, Saba Goodarzi, Amirhossein Hajialigol, Shera Ketabforoush, Afshin Heidari, Hanie Fathi, Arman Shafiee, Hadi Pourjafar

Introduction

Recent studies have emphasized the relationship between mental health and the human intestine microbiota. In this study, we evaluate the effect of consuming Biotics, on levels of depression, anxiety, and cognitive function.

Methods

This meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. We searched MEDLINE (PubMed), Cochrane Library, Scopus, Web of Science, and ClinicalTrials.gov. All full-text articles and major reviews were manually searched for additional studies.

Results

The initial analysis was based on the concept that consuming Biotics causes changes in anxiety, measured using various instruments. This analysis showed that consuming Biotics significantly reduced anxiety in our study participants (SMD = 0.2894, Z = 2.46, P = 0.0139, I^2 = 92.4%). The meta-analysis included 4295 samples (2194 in the experimental group and 2101 in the control group). In terms of depression, the analysis showed that consuming Biotics significantly reduced depression in our study participants (SMD = 0.2942, Z = 2.13, P = 0.0335, I^2 = 91.7%). The meta-analysis included 3179 samples (1603 in the experimental group and 1576 in the control group). Regarding cognitive function, the analysis showed that consuming Biotics significantly improved cognitive function in our study participants (SMD = 0.4819, Z = 3.00, P = 0.0027, I^2 = 77.9%). The meta-analysis included 915 samples (470 in the experimental group and 445 in the control group).

Conclusions

Our results indicate that most recent studies support the effectiveness of probiotics in reducing symptoms of anxiety, depression, and cognitive issues despite some discrepancies in the findings. People with mild symptoms may experience greater benefits from taking probiotics.

Trial Registration

PROSPERO registration ID: CRD42024589507.

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引用次数: 0