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Verbal Weight-Related Abuse and Binge Eating Behavior: The Mediating Role of Attentional Bias to Threat Cues and Difficulties in Emotion Regulation 与体重有关的口头虐待和暴食行为:对威胁线索的注意偏差和情绪调节困难的中介作用》(The Mediating Role of Attentional Bias to Threat Cues and Difficulties in Emotion Regulation.
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70054
Elnaz Salemi, Shaghayegh Zahraei, Gholamreza Dehshiri, Abdolreza Norouzy

Introduction

Previous studies investigated the impact of weight-related abuse (WRA) on eating pathology. However, the circumstances of such an effect are still unclear. Our study aimed to examine the relationship between verbal WRA and binge eating (BE) behavior via attentional bias (AB) to threat cues and difficulties in emotion regulation.

Method

We conducted a parallel mediation model. On the basis of the purposive sampling method, 183 individuals with obesity and overweight (70.5% female and 28.4% male; Meanage = 32.78), from February to June 2019, were recruited from a nutrition clinic in Tehran. The participants completed the BE scale (BES), the weight-related abuse questionnaire (WRAQ), the difficulties in emotion regulation scale (DERS), and the dot probe task (DPT).

Results

AB to threat cues had a significantly negative association with verbal WRA and BE. Difficulties in emotion regulation showed a significant positive association with verbal WRA and BE. The parallel mediation model showed a direct effect of verbal WRA on BE. Moreover, the bootstrap analysis revealed that difficulties in emotion regulation could mediate the association between verbal WRA and BE.

Conclusions

Our findings suggest that experiences of verbal WRA can contribute to cognitive bias to negative emotion, maladaptive emotion regulation strategies, and behavioral problems like BE.

导言:以往的研究调查了体重相关虐待(WRA)对饮食病理学的影响。然而,这种影响的具体情况仍不清楚。我们的研究旨在通过对威胁线索的注意偏差(AB)和情绪调节的困难,探讨口头 WRA 与暴食行为之间的关系:我们建立了一个平行中介模型。根据目的性抽样方法,我们于 2019 年 2 月至 6 月在德黑兰的一家营养诊所招募了 183 名肥胖和超重患者(女性占 70.5%,男性占 28.4%;平均年龄 = 32.78)。参与者完成了BE量表(BES)、体重相关虐待问卷(WRAQ)、情绪调节困难量表(DERS)和点探测任务(DPT):结果:威胁线索 AB 与口头 WRA 和 BE 呈显著负相关。情绪调节困难与口头 WRA 和 BE 呈显著正相关。平行中介模型显示,口头 WRA 对 BE 有直接影响。此外,自引导分析表明,情绪调节方面的困难可以调节言语性 WRA 与 BE 之间的关联:我们的研究结果表明,言语 WRA 的经历会导致对负面情绪的认知偏差、不适应的情绪调节策略以及 BE 等行为问题。
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引用次数: 0
Mendelian Randomization Study Supports Genetic Liability to Obsessive–Compulsive Disorder Associated With the Risk of Alzheimer's Disease 孟德尔随机化研究证实强迫症的遗传易感性与阿尔茨海默病的风险有关。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70081
Si Cao, Han Su, Xiaoyi Zhang, Chao Fang, Nayiyuan Wu, Youjie Zeng, Minghua Chen

Background

Observational studies have suggested that obsessive–compulsive disorder (OCD) may be associated with Alzheimer's disease (AD). However, whether OCD is a causal risk factor for AD remains unclear. This study aimed to assess the causal effect of OCD on AD risk by performing a two-sample Mendelian randomization (MR) analysis.

Methods

Genome-wide association summary statistics were obtained for OCD, comprising 2688 cases and 7037 controls, as well as for AD, including 21,982 cases and 41,944 controls from Kunkle et al.’s study, and 39,918 cases and 358,140 controls from Wightman et al.’s study. On the basis of two diverse thresholds, OCD-associated genetic variants were screened as instrumental variables (IVs) for subsequent MR analyses. Inverse variance weighed was the primary MR method. MR-Egger, weighted median, and weighted mode were used as supplementary MR methods. Various sensitivity tests assessed the reliability of MR results.

Results

On the basis of strict IV selecting thresholds, inverse-variance weighted (IVW) identified significant causal associations between genetic liability to OCD and increased risk of AD in two different sources ((i) Kunkle et al.: odds ratio [OR] = 1.070, 95% confidence interval [CI]: 1.015–1.127, p = 0.012; (ii) Wightman et al. 0.012; (iii) Wightman et al.: OR = 1.051, 95% CI: 1.014–1.090, p = 0.007). Three other supplementary MR methods yielded similar results to IVWs (OR > 1). Furthermore, all results were replicated in MR analyses based on lenient IV selecting thresholds. The sensitivity tests indicated that MR results were stable and not affected by significant horizontal pleiotropy.

Conclusions

This comprehensive MR study suggests that genetic liability to OCD is a causal risk factor for AD. Early intervention in patients with OCD may be beneficial in preventing future AD progression.

背景:观察性研究表明,强迫症(OCD)可能与阿尔茨海默病(AD)有关。然而,强迫症是否是阿尔茨海默病的因果风险因素仍不清楚。本研究旨在通过进行双样本孟德尔随机化(MR)分析,评估强迫症对阿尔茨海默病风险的因果效应:获得了强迫症(包括 2688 例病例和 7037 例对照)和 AD 的全基因组关联汇总统计数据,包括 Kunkle 等人研究中的 21,982 例病例和 41,944 例对照,以及 Wightman 等人研究中的 39,918 例病例和 358,140 例对照。根据两种不同的阈值,强迫症相关遗传变异被筛选为工具变量(IV),用于后续的 MR 分析。反方差权衡是主要的 MR 方法。MR-Egger、加权中位数和加权模式被用作辅助MR方法。各种敏感性测试评估了 MR 结果的可靠性:在严格的 IV 选择阈值的基础上,反方差加权法(IVW)在两个不同的来源中发现了强迫症遗传责任与 AD 风险增加之间的显著因果关系((i) Kunkle 等人:几率比 [OR] = 1.070,95% 置信区间 [CI]:1.015-1.127, p = 0.012;(ii) Wightman et al:OR = 1.051,95% CI:1.014-1.090,p = 0.007)。其他三种辅助 MR 方法的结果与 IVWs 相似(OR > 1)。此外,所有结果都在基于宽松的 IV 选择阈值的 MR 分析中得到了重复。敏感性测试表明,MR 结果稳定,不受显著水平多效性的影响:这项全面的磁共振研究表明,强迫症的遗传易感性是导致注意力缺失症的一个因果风险因素。对强迫症患者进行早期干预可能有利于预防未来的注意力缺失症进展。
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引用次数: 0
The Initial Clinical and Electrophysiological Characteristics of Different Subtypes of Guillain–Barré Syndrome Diagnosed Based on Serial Electrophysiological Examinations 根据连续电生理检查诊断出的格林-巴利综合征不同亚型的初始临床和电生理特点
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70068
Shuo Yang, Na Chen, Lei Zhang, Ying Wang, Lin Chen, Fan Jian, Zaiqiang Zhang, Yilong Wang, Hua Pan

Background

We aimed to identify different Guillain–Barré syndrome (GBS) subtypes, demyelination, axonal degeneration, and reversible conduction failure (RCF) as early as possible by analyzing the initial clinical and electrophysiological examinations.

Methods

This study retrospectively collected GBS patients between October 2018 and December 2022 at Beijing Tiantan Hospital. The diagnostic criteria for the initial electrophysiological study were based on Rajabally's criteria, and the criteria for the serial electrophysiological study were based on Uncini's criteria. All subjects underwent clinical and electrophysiological evaluations at least twice within 8 weeks.

Results

A total of 47 eligible patients with GBS were included, comprising 19 acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 18 axonal degenerations, and 10 RCFs. In the RCF group, 40%, 30%, and 30% patients were diagnosed as AIDP, axonal, and equivocal at the initial study, respectively. The AIDP group had significantly higher cerebrospinal fluid (CSF) protein than the RCF (123.8 [106.4, 215.1] mg/dL vs. 67.1 [36.8, 85.6] mg/dL, = 0.002) and axonal degeneration (123.8 [106.4, 215.1] mg/dL vs. 60.8 [34.8, 113.0] mg/dL, p < 0.001) groups. The RCF group had significantly lower Hughes functional grades at admission (3 [2, 4] vs. 4 [4, 4], = 0.012) and discharge (1.0 [1.0, 2.0] vs. 3.0 [2.0, 3.0], p < 0.001) than the axonal degeneration group and showed significantly shorter distal motor latency (DML), Fmin, Fmean, Fmax, and lower F% than the AIDP group (< 0.05).

Discussion

The early identification of RCF from AIDP had relatively obvious features, including slightly elevated CSF protein levels and normal or slightly prolonged DML and F-wave latencies, contrasting with the apparent elevation and prolongation seen in AIDP. Differentiating RCF from axonal degeneration remains challenging. One potential distinguishing factor is that the motor function in RCF tends to be better than in the latter.

背景:我们旨在通过分析最初的临床和电生理检查,尽早识别不同的格林-巴利综合征(GBS)亚型、脱髓鞘、轴索变性和可逆性传导衰竭(RCF):本研究回顾性收集了北京天坛医院2018年10月至2022年12月期间的GBS患者。初始电生理检查的诊断标准基于Rajabally标准,连续电生理检查的标准基于Uncini标准。所有受试者在 8 周内至少接受了两次临床和电生理评估:共纳入了 47 名符合条件的 GBS 患者,其中包括 19 名急性炎症性脱髓鞘多发性神经病(AIDP)患者、18 名轴索变性患者和 10 名 RCF 患者。在 RCF 组中,40%、30% 和 30% 的患者在初次检查时分别被诊断为 AIDP、轴索变性和等位。AIDP 组的脑脊液(CSF)蛋白(123.8 [106.4, 215.1] mg/dL vs. 67.1 [36.8, 85.6] mg/dL,p = 0.002)和轴索变性(123.8 [106.4, 215.1] mg/dL vs. 60.8 [34.8, 113.0] mg/dL,p min)、Fmean、Fmax 和 F% 均明显高于 RCF 组(p 讨论):RCF 与 AIDP 的早期鉴别特征相对明显,包括 CSF 蛋白水平略有升高,DML 和 F 波潜伏期正常或略有延长,与 AIDP 的明显升高和延长形成鲜明对比。将 RCF 与轴索变性区分开来仍具有挑战性。一个潜在的鉴别因素是,RCF 的运动功能往往优于轴索变性。
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引用次数: 0
Neurophysiological Basis of Electroacupuncture Stimulation in the Treatment of Cardiovascular-Related Diseases: Vagal Interoceptive Loops 电针刺激治疗心血管相关疾病的神经生理学基础:Vagal Interoceptive Loops.
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70076
Yun Liu, Tiancheng Xu, Zhi Yu, Bin Xu

Purpose

The vagal sensory nerve (VSN) is an essential interoceptive pathway that is connected to every level of the body. Its intricate genetic coding provides sustenance for physiological processes, including controlling blood pressure and respiration. Electroacupuncture (EA) is a proven surface stimulation therapy that can regulate vagal nerve activity, which can effectively prevent cardiovascular diseases. A growing number of studies have concentrated on the mapping of VSN codes, but little is known, and the physiological background of how EA influences interoceptive has not been fully explored.

Method

Here, we incorporate the hypothesized interaction among EA targets, VSNs, and the heart. This offers suggestions for using a versatile and focused EA strategy to modify vagal interoceptive awareness to enhance cardiovascular conditions. We first clarified the major role of vagal nerve in the control of cardiac activity. Additionally, we clarified the multidimensional coding pattern in the VSNs, revealing that the targeted control of multimodal interoceptive is the functional basis of the synchronization of cardiovascular system.

Finding

We propose a strategy in which EA of the VSNs is employed to activate the interoceptive loop and reduce the risk of cardiovascular disease.

目的:迷走感觉神经(VSN)是一条重要的感知间通路,连接着身体的各个层面。其复杂的基因编码为包括控制血压和呼吸在内的生理过程提供了营养。电针(EA)是一种行之有效的表面刺激疗法,可以调节迷走神经的活动,从而有效预防心血管疾病。越来越多的研究集中在迷走神经编码的映射上,但对其知之甚少,而 EA 如何影响互感的生理背景也未得到充分探讨:在此,我们将假定的 EA 目标、VSN 和心脏之间的相互作用结合起来。方法:在此,我们将假定的 EA 目标、迷走神经网络和心脏之间的相互作用结合起来,从而为使用多用途、有针对性的 EA 策略提供建议,以改变迷走神经的内感知意识,从而改善心血管状况。我们首先阐明了迷走神经在控制心脏活动中的主要作用。此外,我们还阐明了迷走神经的多维编码模式,揭示了多模态互感的定向控制是心血管系统同步的功能基础:我们提出了一种策略,即利用 VSNs 的 EA 激活互感环路并降低心血管疾病风险。
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引用次数: 0
The Impact of Mindfulness-Based Counseling on the Mental Health of Women With a History of COVID-19 During Pregnancy: A Quasi-Experimental Study 基于正念的心理咨询对孕期有 COVID-19 病史的妇女心理健康的影响:准实验研究
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70062
Najmeh Shahriyari, Shabnam Omidvar, Farideh Mohsenzadeh-Ledari, Alireza Azizi, Hemmat Gholinia
<div> <section> <h3> Introduction</h3> <p>With the spread of COVID-19, certain population groups, including pregnant women, were more susceptible than others. This disease can lead to postpartum complications, including mental disorders, in mothers. Few studies have investigated the impact of mindfulness-based interventions on mental health, and the most effective counseling approach to promote mental health has not been identified.</p> </section> <section> <h3> Objective</h3> <p>This study aimed to determine the impact of online mindfulness-based counseling on improving mental health among women with a history of COVID-19 during pregnancy in Iran.</p> </section> <section> <h3> Methods</h3> <p>The present study was a quasi-experimental design conducted on 100 women with a history of coronavirus infection during pregnancy referred to the Mother's Clinic of Yahya Nejad and Ayatollah Rouhani Educational-Treatment Hospital, affiliated with Babol University of Medical Sciences, Iran, via convenience sampling. The women were randomly assigned to the intervention (mindfulness-based counseling) and control groups. The intervention group received eight 45-min weekly mindfulness-based counseling sessions over 8 weeks. Data were collected via a demographic information questionnaire and the Goldberg General Health Questionnaire before and after the intervention, which were completed by both groups. Independent <i>t</i>-tests and analysis of covariances (ANCOVAs) were used to compare the outcomes of the two groups.</p> </section> <section> <h3> Results</h3> <p>After controlling for confounding variables, the mean mental health scores before and after counseling were 29.42 ± 4.49 and 19.80 ± 3.88, respectively, in the intervention group and 26.26 ± 2.29 and 25.92 ± 2.15, respectively, in the control group. The mean mental health score in the intervention group was significantly lower than that in the control group (<i>F</i> = 266.7, <i>p</i> < 0.001). The mean scores for somatic symptoms (<i>F</i> = 89.30, <i>p</i> < 0.001), depression symptoms (<i>F</i> = 142.71, <i>p</i> < 0.001), anxiety and insomnia symptoms (<i>F</i> = 120.56, <i>p</i> < 0.001), and social dysfunction scores (<i>F</i> = 127.77, <i>p</i> < 0.001) were significantly different between the two groups after counseling.</p> </section> <section> <h3> Conclusion</h3> <p>The findings indicated that online mindfulness-based counseling positively affects mental health and its domains du
导言:随着 COVID-19 的传播,包括孕妇在内的某些人群比其他人更容易感染。这种疾病可导致母亲产后并发症,包括精神障碍。很少有研究调查基于正念的干预措施对心理健康的影响,促进心理健康的最有效咨询方法也尚未确定:本研究旨在确定基于正念的在线咨询对改善伊朗孕期有 COVID-19 病史的妇女的心理健康的影响:本研究采用准实验设计,通过方便抽样的方式,对伊朗巴博勒医科大学附属叶海亚-内贾德和阿亚图拉-鲁哈尼教育治疗医院母亲诊所转诊的 100 名孕期冠状病毒感染史妇女进行研究。这些妇女被随机分配到干预组(正念咨询)和对照组。干预组接受为期 8 周、每周 8 次、每次 45 分钟的正念心理辅导。通过干预前后的人口统计学信息问卷和戈德伯格一般健康问卷收集数据,两组均填写了问卷。采用独立 t 检验和协方差分析(ANCOVA)来比较两组的结果:在控制了混杂变量后,干预组在咨询前后的平均心理健康得分分别为(29.42±4.49)分和(19.80±3.88)分,对照组分别为(26.26±2.29)分和(25.92±2.15)分。研究结果表明,基于正念的在线心理咨询对产后期间的心理健康及其领域有积极影响。然而,在得出最终结论之前,还需要进一步的随机临床试验:根据我国法律,我们不允许注册。
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引用次数: 0
Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis 神经质与创伤后应激障碍:孟德尔随机分析
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70041
Zifan You, Shanshan Chen, Jinsong Tang

Objective

Epidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the development of PTSD.

Method

We obtained data on three neuroticism clusters, PTSD, and nine other psychiatric disorders from genome-wide association studies summary statistics and employed univariable, multivariable, and mediation MR analyses to explore causal associations among them.

Results

Neuroticism clusters were linked with PTSD (depressed affect (odds ratio [OR]: 2.94 [95% confidence interval: 2.21–3.92]); SESA (2.69 [1.95–3.71]; worry (1.81 [1.37–2.99])). Neuroticism clusters were also associated with psychiatric disorders, with the depressed effect on panic disorder (PD) (2.60 [1.14–5.91]), SESA on anorexia nervosa (AN) (2.77 [1.95–3.94]) and schizophrenia (2.55 [1.99–3.25]), worry on major depressive disorder (MDD) (2.58 [2.19–3.05]). In multivariable MR, only the SESA-PTSD association remained (2.60 [2.096, 3.107]) while worry-PTSD and depressed affect-PTSD associations attenuated to nonsignificance. Mediation MR analyses suggested that PD mediated 3.76% of the effect of depressed effect on PTSD and AN mediated 10.33% of the effect of SESA on PTSD.

Conclusion

Delving deeper into neuroticism clusters, we comprehensively understand the role of neuroticism in PTSD.

目的:流行病学研究显示,神经质与创伤后应激障碍(PTSD)之间存在尚未确定的关联,因此我们进行了泯灭随机化(MR)分析,以研究神经质集群中的担忧、抑郁情绪以及对环境压力和逆境的敏感性(SESA)是否与创伤后应激障碍的发展有关:我们从全基因组关联研究的汇总统计中获得了三个神经质群组、创伤后应激障碍和其他九种精神疾病的数据,并采用单变量、多变量和中介MR分析来探讨它们之间的因果关联:神经质群组与创伤后应激障碍(情绪低落(几率比[OR]:2.94 [95%置信区间:2.21-3.92]);SESA(2.69 [1.95-3.71];担忧(1.81 [1.37-2.99]))有关。神经质群组也与精神障碍有关,抑郁对惊恐障碍(PD)(2.60 [1.14-5.91] )、SESA 对神经性厌食症(AN)(2.77 [1.95-3.94] )和精神分裂症(2.55 [1.99-3.25])、担忧对重度抑郁障碍(MDD)(2.58 [2.19-3.05])有影响。在多变量磁共振分析中,只有 SESA 与创伤后应激障碍的相关性保持不变(2.60 [2.096, 3.107]),而担忧与创伤后应激障碍和抑郁情绪与创伤后应激障碍的相关性则减弱至无显著性。中介MR分析表明,PD中介了抑郁对创伤后应激障碍影响的3.76%,AN中介了SESA对创伤后应激障碍影响的10.33%:通过深入研究神经质群组,我们全面了解了神经质在创伤后应激障碍中的作用。
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引用次数: 0
The Monocyte-to-Lymphocyte Ratio Was Associated With Intraplaque Neovascularization of the Carotid Artery on AngioPLUS 单核细胞与淋巴细胞比率与 AngioPLUS 显示的颈动脉斑块内新生血管有关。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70058
Mingfeng Zhai, Xiao Sun, Jian Wang, Jimei Xu, Fuqin Bian, Menglin Wu, Yafei Yang, Hongwei Chen, Jinghong Lu

Background

The monocyte–lymphocyte ratio (MLR) is a hematological test parameter that reflects the status of both monocytes and lymphocytes as inflammatory cells. This study aims to investigate the relationship between MLR and carotid intraplaque neovascularization (IPN) in patients with asymptomatic carotid stenosis.

Methods

We performed the Angio Planewave Ultrasensitive (AngioPLUS) screening for patients with carotid plaques. The carotid plaque stability was evaluated by semiquantitative visual grading of carotid IPN. Binary logistic regression models were performed to determine the associations between different clinical and laboratory indicators and the presence of high IPN.

Results

A total of 160 patients were eventually enrolled with 99 in the low IPN group (Scores 0–1) and 61 in the high IPN group (Score 2). Univariate logistic regression showed that age, monocytes, lymphocytes, glycated hemoglobin (HbA1c), fibrinogen, d-dimmer, and MLR were significantly associated with the presence of high IPN (all p < 0.05). Multivariate logistic regression models showed that MLR was significantly associated with the presence of high IPN after adjusting for other covariates. An MLR value of 32.9 was the optimal cutoff value to differentiate high and low IPN. High MLR was also significantly correlated with the presence of high IPN (odds ratio [OR] = 4.08, 95% confidence interval [CI]: 1.69–9.88, p = 0.002) when included in the above multivariate logistic regression model.

Conclusion

Elevated MLR is closely associated with the presence of high IPN and may serve as a surrogate biomarker for carotid IPN.

背景:单核细胞-淋巴细胞比值(MLR)是反映单核细胞和淋巴细胞作为炎症细胞状态的血液学检测参数。本研究旨在探讨无症状颈动脉狭窄患者的单核细胞-淋巴细胞比值与颈动脉斑块内新生血管(IPN)之间的关系:我们对颈动脉斑块患者进行了Angio Planewave Ultrasensitive(AngioPLUS)筛查。通过对颈动脉IPN进行半定量视觉分级来评估颈动脉斑块的稳定性。通过二元逻辑回归模型确定不同临床和实验室指标与高IPN之间的关联:最终共有 160 名患者入选,其中低 IPN 组(0-1 分)99 人,高 IPN 组(2 分)61 人。单变量逻辑回归显示,年龄、单核细胞、淋巴细胞、糖化血红蛋白(HbA1c)、纤维蛋白原、d-二聚体和 MLR 与高 IPN 存在显著相关(均为 p 结论:MLR 升高与高 IPN 密切相关:MLR 升高与高 IPN 密切相关,可作为颈动脉 IPN 的替代生物标志物。
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引用次数: 0
Brain Functional Alterations in Patients With Benign Paroxysmal Positional Vertigo Demonstrate the Visual–Vestibular Interaction and Integration 良性阵发性位置性眩晕患者的大脑功能变化显示了视觉与前庭的相互作用和整合。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70053
Jing Wu, Liang Shu, Chen-Yan Zhou, Xiao-Xia Du, Xu-Hong Sun, Hui Pan, Guo-Hong Cui, Jian-Ren Liu, Wei Chen
<div> <section> <h3> Objective</h3> <p>This study aimed to analyze the features of resting-state functional magnetic resonance imaging (rs-fMRI) and clinical relevance in patients with benign paroxysmal positional vertigo (BPPV) that have undergone repositioning maneuvers.</p> </section> <section> <h3> Methods</h3> <p>A total of 38 patients with BPPV who have received repositioning maneuvers and 38 matched healthy controls (HCs) were enrolled in the present study from March 2018 to August 2021. Imaging analysis software was employed for functional image preprocessing and indicator calculation, mainly including the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), percent amplitude of fluctuation (PerAF), and seed-based functional connectivity (FC). Statistical analysis of the various functional indicators in patients with BPPV and HCs was also conducted, and correlation analysis with clinical data was performed.</p> </section> <section> <h3> Results</h3> <p>Patients with BPPV displayed decrease in ALFF, fALFF, and PerAF values, mainly in the bilateral occipital lobes in comparison with HCs. Additionally, their ALFF and fALFF values in the proximal vermis region of the cerebellum increased relative to HCs. The PerAF values in the bilateral paracentral lobules, the right supplementary motor area (SMA), and the left precuneus decreased in patients with BPPV and were negatively correlated with dizziness visual analog scale (VAS) scores 1 week after repositioning (W1). In addition, in the left fusiform gyrus and lingual gyrus, the PerAF values show a negative correlation with dizziness handicap inventory (DHI) scores at initial visit (W0). Seed-based FC analysis using the seeds from differential clusters of fALFF, ALFF, and PerAF showed reductions between the left precuneus and bilateral occipital lobe, the left precuneus and left paracentral lobule, and within the occipital lobes among patients with BPPV.</p> </section> <section> <h3> Conclusion</h3> <p>The spontaneous activity of certain brain regions in the bilateral occipital and frontoparietal lobes of patients with BPPV was reduced, whereas the activity in the cerebellar vermis was increased. Additionally, there were reductions in FC between the precuneus and occipital cortex or paracentral lobule, as well as within the occipital cortex. The functional alterations in these brain regions may be associated with the inhibitory interaction and functional integration of visual, vestibular, and sensorimotor systems. The functional alterations observed in the visual cortex and precu
研究目的本研究旨在分析接受过复位手法的良性阵发性位置性眩晕(BPPV)患者的静息态功能磁共振成像(rs-fMRI)特征及临床意义:本研究从2018年3月至2021年8月共招募了38名接受过复位手法治疗的BPPV患者和38名匹配的健康对照组(HCs)。采用成像分析软件进行功能图像预处理和指标计算,主要包括低频波动振幅(ALFF)、分数ALFF(fALFF)、波动振幅百分比(PerAF)和基于种子的功能连接性(FC)。此外,还对BPPV患者和HCs患者的各项功能指标进行了统计分析,并与临床数据进行了相关性分析:结果:与 HCs 相比,BPPV 患者的 ALFF、fALFF 和 PerAF 值均有所下降,主要集中在双侧枕叶。此外,小脑近端蚓部的 ALFF 和 fALFF 值与 HCs 相比有所增加。BPPV患者双侧旁中心小叶、右侧辅助运动区(SMA)和左侧楔前区的PerAF值下降,并与复位一周后(W1)的眩晕视觉模拟量表(VAS)评分呈负相关。此外,在左侧纺锤回和舌回,PerAF 值与初次就诊时(W0)的眩晕障碍量表(DHI)评分呈负相关。使用 fALFF、ALFF 和 PerAF 差异群的种子进行的基于种子的 FC 分析表明,在 BPPV 患者中,左侧楔前叶和双侧枕叶之间、左侧楔前叶和左侧枕旁小叶之间以及枕叶内部的活动减少:结论:BPPV 患者双侧枕叶和顶叶某些脑区的自发活动减少,而小脑蚓部的活动增加。此外,楔前叶与枕叶皮质或枕叶旁中心小叶之间以及枕叶皮质内部的FC也有所降低。这些脑区的功能改变可能与视觉、前庭和感觉运动系统的抑制性相互作用和功能整合有关。在视觉皮层和楔前皮层观察到的功能改变可能是与残余眩晕有关的适应性反应。
{"title":"Brain Functional Alterations in Patients With Benign Paroxysmal Positional Vertigo Demonstrate the Visual–Vestibular Interaction and Integration","authors":"Jing Wu,&nbsp;Liang Shu,&nbsp;Chen-Yan Zhou,&nbsp;Xiao-Xia Du,&nbsp;Xu-Hong Sun,&nbsp;Hui Pan,&nbsp;Guo-Hong Cui,&nbsp;Jian-Ren Liu,&nbsp;Wei Chen","doi":"10.1002/brb3.70053","DOIUrl":"10.1002/brb3.70053","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to analyze the features of resting-state functional magnetic resonance imaging (rs-fMRI) and clinical relevance in patients with benign paroxysmal positional vertigo (BPPV) that have undergone repositioning maneuvers.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 38 patients with BPPV who have received repositioning maneuvers and 38 matched healthy controls (HCs) were enrolled in the present study from March 2018 to August 2021. Imaging analysis software was employed for functional image preprocessing and indicator calculation, mainly including the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), percent amplitude of fluctuation (PerAF), and seed-based functional connectivity (FC). Statistical analysis of the various functional indicators in patients with BPPV and HCs was also conducted, and correlation analysis with clinical data was performed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients with BPPV displayed decrease in ALFF, fALFF, and PerAF values, mainly in the bilateral occipital lobes in comparison with HCs. Additionally, their ALFF and fALFF values in the proximal vermis region of the cerebellum increased relative to HCs. The PerAF values in the bilateral paracentral lobules, the right supplementary motor area (SMA), and the left precuneus decreased in patients with BPPV and were negatively correlated with dizziness visual analog scale (VAS) scores 1 week after repositioning (W1). In addition, in the left fusiform gyrus and lingual gyrus, the PerAF values show a negative correlation with dizziness handicap inventory (DHI) scores at initial visit (W0). Seed-based FC analysis using the seeds from differential clusters of fALFF, ALFF, and PerAF showed reductions between the left precuneus and bilateral occipital lobe, the left precuneus and left paracentral lobule, and within the occipital lobes among patients with BPPV.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The spontaneous activity of certain brain regions in the bilateral occipital and frontoparietal lobes of patients with BPPV was reduced, whereas the activity in the cerebellar vermis was increased. Additionally, there were reductions in FC between the precuneus and occipital cortex or paracentral lobule, as well as within the occipital cortex. The functional alterations in these brain regions may be associated with the inhibitory interaction and functional integration of visual, vestibular, and sensorimotor systems. The functional alterations observed in the visual cortex and precu","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic immune-inflammation index predicts short-term mortality in acute ischemic stroke with severe stenosis of internal carotid artery associated pneumonia 全身免疫炎症指数可预测颈内动脉严重狭窄伴肺炎的急性缺血性中风患者的短期死亡率。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70047
Yi Yang, Peng He, Yongbo Zhang

Background

We aimed to investigate the relationship between systemic immune-inflammation index (SII) and short-term mortality in acute ischemic stroke (AIS) with internal carotid artery (ICA) severe stenosis and stroke associated pneumonia (SAP) patients.

Methods

Information on general demographic, laboratory data, CT angiography, magnetic resonance angiography, or digital subtraction angiography were obtained. The predictive power was evaluated by assessing the area under the receiver operating characteristic (ROC) curve. The logistic regression was performed to assess the association of SII and short-term mortality in severe stenosis ICA-AIS and SAP patients.

Result

Among 342 patients with severe stenosis ICA-AIS and SAP, death occurred in 66 patients during 120 days follow-up. Multivariate regression analyses indicated that increased SII predicts higher mortality in 120 days follow-up, and the risk of short-term mortality in SII > 666.31 × 109/L group is increased 4.671-fold. Patients with SII > 666.31 × 109/L had higher proportion of male, hypertension, smoking, higher admission NIHSS score, higher systolic blood pressure, and higher proportion of 120 days mortality. Higher SII predicted a worse 120 days mortality was worked out by Kaplan–Meier methods.

Conclusion

An elevated SII was remarkably associated with 120 days mortality in severe stenosis ICA-AIS and SAP patients.

研究背景我们旨在研究颈内动脉(ICA)严重狭窄的急性缺血性卒中(AIS)和卒中相关肺炎(SAP)患者的全身免疫炎症指数(SII)与短期死亡率之间的关系:获取一般人口统计学、实验室数据、CT 血管造影术、磁共振血管造影术或数字减影血管造影术的信息。通过评估接收者操作特征曲线(ROC)下的面积来评估预测能力。对严重狭窄的ICA-AIS和SAP患者的SII与短期死亡率的关系进行了逻辑回归评估:结果:在342例重度狭窄ICA-AIS和SAP患者中,有66例患者在120天的随访期间死亡。多变量回归分析表明,SII的增加预示着随访120天的死亡率会升高,SII>666.31×109/L组的短期死亡风险增加了4.671倍。SII > 666.31 × 109/L 组患者中男性、高血压、吸烟比例较高,入院时 NIHSS 评分较高,收缩压较高,120 天死亡率较高。通过卡普兰-梅耶法计算,SII越高,120天死亡率越低:结论:SII升高与严重狭窄的ICA-AIS和SAP患者的120天死亡率明显相关。
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引用次数: 0
Causal Relationship Between Post-Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study 创伤后应激障碍与免疫细胞特征之间的因果关系:孟德尔随机化研究》。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70073
Jian Wang, Yuan Shao, Xianhua Deng, Jianbin Du

Introduction

Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that occurs after exposure to catastrophic-level experiences. Although alterations in immune function have been identified in individuals with PTSD, the causal relationship between the two remains unclear.

Methods

To investigate the causal relationship between PTSD and immune function, we conducted the forward and backward two-sample Mendelian randomization (MR) analyses, based on summary-level genome-wide association studies (GWAS) data on PTSD and immune cell traits.

Results

For the forward MR analysis, PTSD was found to reduce the levels of CD62L− dendritic cell (DC) (beta = −0.254, FDR = 0.01), CD86+ myeloid DC (beta = −0.238, FDR = 0.014), CD62L− myeloid DC (beta = −0.26, FDR = 0.01), CD62L− CD86+ myeloid DC absolute count (beta = −0.264, FDR = 0.024), and CD62L− CD86+ myeloid DC (beta = −0.328, FDR = 0.002). In contrast, PTSD was observed to increase the level of CD28− CD8dim T-cell absolute count (beta = 0.27, FDR = 0.029). For the backward MR analysis, the odds ratio (OR) for CD33 on CD33dim HLA DR+ CD11b− in relation to PTSD risk was found to be 1.045 (95% CI = 1.021–1.069, FDR = 0.008). The OR for FSC-A on HLA DR+ CD8br was 1.048 (95% CI = 1.018–1.079, FDR = 0.039) and for CCR2 on CD14− CD16+ monocyte was 1.059 (95% CI = 1.027–1.092, FDR = 0.008). No significant pleiotropy was detected in both forward and backward MR analyses.

Conclusion

The bidirectional MR study shed light on the intricate interplay between immune function and PTSD. The identification of a bidirectional causal relationship between T cells and PTSD opens new avenues for considering innovative approaches to the prevention and early intervention of PTSD.

简介创伤后应激障碍(PTSD)是一种使人衰弱的心理疾病,发生于遭受灾难性经历之后。虽然已发现创伤后应激障碍患者的免疫功能发生了改变,但两者之间的因果关系仍不清楚:为了研究创伤后应激障碍与免疫功能之间的因果关系,我们根据创伤后应激障碍和免疫细胞特质的全基因组关联研究(GWAS)数据,进行了正向和反向双样本孟德尔随机化(MR)分析:结果:在前向 MR 分析中,发现创伤后应激障碍会降低 CD62L- 树突状细胞(DC)(β = -0.254,FDR = 0.01)、CD86+ 髓样 DC(β = -0.238,FDR = 0.014)、CD62L- 髓样 DC(β = -0.26,FDR = 0.01)、CD62L- CD86+ 髓样 DC 绝对计数(β = -0.264,FDR = 0.024)和 CD62L- CD86+ 髓样 DC(β = -0.328,FDR = 0.002)。相反,创伤后应激障碍会增加 CD28- CD8dim T 细胞绝对计数水平(β = 0.27,FDR = 0.029)。在反向 MR 分析中,CD33dim HLA DR+ CD11b- 上的 CD33 与创伤后应激障碍风险的比值比 (OR) 为 1.045(95% CI = 1.021-1.069,FDR = 0.008)。HLA DR+ CD8br 的 FSC-A OR 为 1.048(95% CI = 1.018-1.079,FDR = 0.039),CD14- CD16+ 单核细胞的 CCR2 OR 为 1.059(95% CI = 1.027-1.092,FDR = 0.008)。正向和反向磁共振分析均未发现明显的多向性:双向磁共振研究揭示了免疫功能与创伤后应激障碍之间错综复杂的相互作用。T细胞与创伤后应激障碍之间双向因果关系的确定为考虑预防和早期干预创伤后应激障碍的创新方法开辟了新途径。
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引用次数: 0
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Brain and Behavior
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