Brain and Behavior最新文献_第4页

The Chain Mediating Effect of Instrumental Activities of Daily Living and Regular Exercise in the Relationship Between Physical Performance and Cognitive Function Among Older Adults Comorbid With Diabetes Mellitus and Hypertension. 日常生活工具活动与规律运动在老年糖尿病高血压患者身体表现与认知功能关系中的链式中介作用

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-03-01 DOI: 10.1002/brb3.71305

Chao Sun, Huixiu Hu, Xiaoyan Zhang, Yajie Zhao, Wei Gu

Purpose: To develop a chain mediation model to elucidate the relationship among physical performance, instrumental activities of daily living (IADL), regular exercise, and cognitive function among older adults who are comorbid with diabetes mellitus and hypertension (OA-DM&HTN).

Methods: A total of 656 participants were investigated with the Mini-Mental State Examination, the Short Physical Performance Battery, the Instrumental Activities of Daily Living, and a questionnaire on regular exercise frequency between January and September 2022. Sequential multiple mediation models were conducted to analyze the data.

Results: The average age of the participants was 73.47 ± 7.40 years, and 49.24% (n = 323) of participants were female. The average cognitive function score was 22.36 ± 6.14, and 32.62% (n = 214) of participants exhibited cognitive impairment. Cognitive performance exhibited significant associations with demographic factors, including gender, age, marriage status, educational background, and income level (p < 0.05). Chain mediation analysis indicated that physical performance directly predicted cognitive function (β = 0.525, 95% CI: 0.000-1.050); physical performance had indirect effects mediated by IADL (β = 0.917, 95% CI: 0.635-1.230) and regular exercise (β = 0.076, 95% CI: 0.003-0.180). A significant chain-mediating effect involving both IADL and regular exercise was also observed on the relationship between physical performance and cognitive function (β = 0.034, 95% CI: 0.002-0.071).

Conclusion: Physical performance is a significant predictor of cognitive function, and it can also affect cognitive function through the independent or chain-mediating effects of IADL and regular exercise among OA-DM&HTN. Therefore, to delay cognitive decline among OA-DM&HTN, it is essential to provide tailored functional training, encourage improvement in IADL, and promote regular exercise among OA-DM&HTN.

目的：建立链式中介模型，探讨老年糖尿病合并高血压（OA-DM&HTN）患者身体机能、日常生活工具活动（IADL）、规律运动与认知功能之间的关系。方法：在2022年1月至9月期间，对656名参与者进行了小型精神状态检查、短期体能表现电池、日常生活工具活动和定期运动频率问卷调查。采用顺序多重中介模型对数据进行分析。结果：参与者的平均年龄为73.47±7.40岁，女性占49.24% （n = 323）。平均认知功能评分为22.36±6.14分，32.62% （n = 214）的参与者表现出认知功能障碍。认知表现与性别、年龄、婚姻状况、学历、收入水平等人口统计学因素显著相关（p < 0.05）。链式中介分析表明，体能表现直接预测认知功能（β = 0.525, 95% CI: 0.000 ~ 1.050）；体力表现受IADL （β = 0.917, 95% CI: 0.635 ~ 1.230）和规律运动（β = 0.076, 95% CI: 0.003 ~ 0.180）的间接影响。在生理表现与认知功能的关系上，IADL和常规运动均存在显著的连锁中介效应（β = 0.034, 95% CI: 0.002-0.071）。结论：体能表现是OA-DM&HTN认知功能的重要预测因子，也可通过IADL与规律运动的独立或连锁作用影响OA-DM&HTN的认知功能。因此，为了延缓OA-DM&HTN认知能力的下降，有必要提供针对性的功能训练，鼓励改善IADL，并促进OA-DM&HTN的定期锻炼。

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引用次数: 0

Detecting Malingered COVID-19 Symptoms Using the Verifiability Approach 使用可验证性方法检测伪造的COVID-19症状。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-20 DOI: 10.1002/brb3.71278

Raffaella Maria Ribatti, Tiziana Lanciano, Antonietta Curci

Introduction:

The COVID-19 pandemic has heightened concerns about malingering, particularly given its recognition as an occupational disease in several regions. This study evaluated the applicability of the Verifiability Approach (VA), a credibility assessment tool based on the principle that liars provide fewer verifiable details than truth tellers, to distinguish between honest reporters and malingerers of COVID-19 infection.

Methods

A total of 410 participants (51.5% female) completed an online survey via Google Forms. Participants who reported previous COVID-19 infection (n = 205) were assigned to either an informed honest (n = 104) or not-informed honest (n = 101) group, while those without prior infection (n = 205) were assigned to informed malingerers (n = 105) or not-informed malingerers (n = 100) conditions. Participants in the informed condition were briefed about the VA before writing their reports.

Results:

Informed honest participants provided significantly more verifiable details than both uninformed honest participants and malingerers. The number of verifiable details and the ratio of verifiable details to total details were strongly associated with honesty when participants were informed about the VA, indicating that the information Protocol enhanced diagnostic accuracy. Perceived success was higher among honest participants, particularly those informed about the VA. No significant effects emerged for reported long COVID or fabricated symptoms, likely due to limited variability and low symptom familiarity.

Conclusion:

The findings support the VA's validity in distinguishing genuine from feigned symptom reports in health-related contexts. However, the fully online design, lack of factual verification, and potential for misreporting represent key limitations. Future studies should replicate these results in face-to-face or ecologically valid settings and extend the VA framework to the study of symptom dissimulation.

导语：COVID-19大流行加剧了人们对装病的担忧，特别是考虑到其在一些地区被认定为职业病。该研究以“说谎者提供的可验证的细节比真话者少”为原则，评估了可信度评估工具“可验证性方法”（VA）在区分诚实记者和新冠病毒感染者方面的适用性。方法：共有410名参与者（51.5%为女性）通过谷歌表格完成在线调查。报告先前感染COVID-19的参与者（n = 205）被分配到知情诚实组（n = 104）或不知情诚实组（n = 101），而没有感染的参与者（n = 205）被分配到知情装病组（n = 105）或不知情装病组（n = 100）。在撰写报告之前，知情条件下的参与者简要介绍了退伍军人管理局。结果：知情的诚实参与者比不知情的诚实参与者和装病者提供了更多可验证的细节。当参与者被告知VA时，可验证细节的数量和可验证细节与总细节的比例与诚实度密切相关，表明信息协议提高了诊断的准确性。诚实的参与者，特别是那些了解VA的参与者，感知到的成功更高。对于报告的长期COVID或捏造的症状，没有出现显着影响，可能是由于有限的可变性和对症状的熟悉程度较低。结论：研究结果支持VA在区分与健康相关的真实和虚假症状报告方面的有效性。然而，完全在线的设计，缺乏事实验证，以及潜在的误报是主要的限制。未来的研究应该在面对面或生态有效的环境中复制这些结果，并将VA框架扩展到症状掩饰的研究中。

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引用次数: 0

Psychedelic- and Substance-Assisted Therapies in Global Mental Health: Bridging Cultures, Evidence, and Access, 全球精神健康中的致幻剂和物质辅助疗法：连接文化、证据和获取途径。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71265

Simon Halm

Psychedelic- and substance-assisted therapies, including MDMA, psilocybin, and ketamine, are gaining attention for conditions such as PTSD and depression, yet their development and implementation remain largely concentrated in high-income settings. This graphical abstract summarizes the central argument of the commentary: while these interventions may hold relevance for global mental health, particularly in conflict-affected and humanitarian contexts, their equitable use is constrained by cultural, ethical, regulatory, and resource-related challenges. Responsible implementation requires culturally grounded, ethically robust, and context-sensitive pathways rather than uncritical expansion.

致幻剂和药物辅助疗法，包括MDMA、裸盖菇素和氯胺酮，正在引起人们对创伤后应激障碍和抑郁症等疾病的关注，但它们的发展和实施主要集中在高收入环境中。这一图形摘要总结了评注的中心论点：虽然这些干预措施可能与全球精神卫生有关，特别是在受冲突影响和人道主义背景下，但它们的公平使用受到文化、伦理、监管和资源相关挑战的限制。负责任的实施需要以文化为基础、道德健全、环境敏感的途径，而不是不加批判的扩张。

引用次数: 0

Deep Brain Stimulation for Post-Stroke Movement Disorders of Various Etiologies: An Individual Participant Data (IPD) Meta-Analysis 脑深部刺激治疗脑卒中后各种病因的运动障碍：个体参与者数据（IPD）荟萃分析。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71270

Thomas Kinfe, Sanjay Pandey, Martin Regensburger, Maximilian Zaubitzer, Achim Schilling, Steffen Brenner

Background

Post-stroke movement disorders consisting of complex involuntary movement patterns with parkinsonism, dystonia, hemiballismus/hemichorea, and tremor represent a therapeutical challenge. Deep brain stimulation has been considered an effective treatment option, although it remains unclear which DBS targets should be approached.

Methods

An individual participant data meta-analysis was conducted analyzing the efficacy (Burke Fahn Marsden Dystonia Rating Scale (BFM)-motor/-disability and the Fahn-Tolosa-Marín Scale for tremor (FTMTRS)) of pallidal (GPi) deep brain stimulation versus thalamic (VIM) versus GPi + VIM. PubMed, Embase, Cochrane Library, Ovid Medline, and Scopus were searched from 2000 to 2025. Additionally, correlation/regression analyses (age, duration of disease, stimulation parameters) were performed.

Results

Sixteen studies including 32 patients (34.4% male; 65.6% female) were enrolled targeting the GPi (63.2%) versus VIM (23.6%) versus GPi/VIM-DBS (13.2%). Dystonia with tremor was found in 53%, dystonia with hemichorea/choreoathetosis in 50% (age at disease onset: 10 ± 18 years, age at DBS surgery: 37 ± 15 years, disease duration: 28 ± 19 years). GPi-DBS improved dystonia (BFM-motor: 6–12 months p < 0.005 and >12 months p = 0.038; BFM-disability 6–12 months p = 0.038) with no significant/relevant changes for VIM and GPi/VIM. No correlations were determined between DBS outcome and stimulation protocol and demographic characteristics. Adverse events occurred in 19%.

Conclusion

DBS is effective for treating post-stroke movement disorders of various etiologies. Given the heterogeneity, selection, and reporting bias, the published data is limited in providing high-quality evidence. Hence, the authors advocate a multifocal DBS approach along with trial stimulation determined under a rigorous study protocol.

背景：卒中后运动障碍包括复杂的不自主运动模式，包括帕金森病、肌张力障碍、偏瘫/偏窄和震颤，这是一项治疗挑战。深部脑刺激被认为是一种有效的治疗选择，尽管尚不清楚应该接近哪个DBS靶点。方法：对个体参与者数据进行meta分析，分析pallidal （GPi）深部脑刺激与丘脑深部脑刺激（VIM）与GPi + VIM的疗效(Burke Fahn Marsden肌张力障碍评定量表（BFM)-运动/-残疾和Fahn-Tolosa-Marín震颤量表（FTMTRS））。PubMed, Embase, Cochrane Library， Ovid Medline和Scopus从2000年到2025年进行了检索。此外，进行相关/回归分析（年龄、疾病持续时间、刺激参数）。结果：纳入16项研究，包括32例患者（34.4%男性，65.6%女性），目标是GPi (63.2%) vs VIM (23.6%) vs GPi/VIM- dbs（13.2%）。肌张力障碍伴震颤者占53%，肌张力障碍伴血凝/舞蹈症者占50%（发病年龄：10±18岁，DBS手术年龄：37±15岁，病程：28±19年）。GPi- dbs改善肌张力障碍（BFM-motor: 6-12个月p < 0.005, >: 12个月p = 0.038； bfm -残疾：6-12个月p = 0.038）， VIM和GPi/VIM无显著/相关变化。DBS结果与刺激方案和人口学特征之间没有相关性。不良事件发生率为19%。结论：DBS对脑卒中后各种病因的运动障碍均有较好的治疗效果。考虑到异质性、选择性和报告偏倚，已发表的数据在提供高质量证据方面是有限的。因此，作者主张采用多焦点DBS方法以及在严格的研究方案下确定的试验刺激。

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引用次数: 0

Findings on Impact of Circadian Genes and Bipolar Disorder: A Bibliometric Analysis From 1996 to 2024 昼夜节律基因与双相情感障碍影响的研究结果：1996年至2024年的文献计量分析。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71274

Zhuoer Ruan, Jie Zhu

Introduction

The disturbances of circadian genes are implicated in the pathophysiology of bipolar disorder (BD). This bibliometric analysis aims to explore global trends and hotspots in research on circadian genes and BD.

Design

A bibliometric analysis.

Methods

A systematic search was carried out on the Web of Science Core Collection (WoSCC) database to collect publications regarding circadian genes and BD. Subsequently, bibliometric analysis and visualization utilized VOSviewer (V 1.6.20), CiteSpace (V 6.3.R1), and the R package “Bibliometrix” (V 4.3.3).

Results

The 400 articles involved 2405 authors from 1649 institutions, citing 18,840 sources in 166 journals. The number of publications has been consistently rising, with a 9.88% annual growth rate. The USA, Italy, and China dominated with the most articles. The most cited articles focused on the genetics of circadian disorders. The top institutions were the University of California system, the University of California, San Diego, and Université Paris. High-impact authors included McClung Colleen A., McCarthy Michael J., and Benedetti Francesco. The top journals by H-index were Chronobiology International, Journal of Affective Disorders, and American Journal of Medical Genetics. The keyword co-occurrence analysis revealed focus on “depression,” “neurons,” “light therapy,” “genome wide association,” and “lithium.” The burst keywords highlighted the latest trends, including “sleep” and “brain,” with consistent emphasis on “risk.”

Conclusion:

This bibliometric analysis provides insights into the global trends and hotspots of research on circadian genes and BD. The hotspots are on symptoms, genetic associations, and treatment in BD, with frontiers exploring sleep patterns, brain functions, and risk factors.

昼夜节律基因的紊乱与双相情感障碍（BD）的病理生理有关。本文献计量分析旨在探讨昼夜节律基因和生物钟研究的全球趋势和热点。设计：文献计量分析。方法：系统检索Web of Science Core Collection （WoSCC）数据库中有关昼夜节律基因和BD的出版物，利用VOSviewer （v1.6.20）、CiteSpace （v6.3）进行文献计量学分析和可视化。R1)和R包“Bibliometrix”（v4.3.3）。结果：400篇文章涉及2405位作者，来自1649个机构，引用来源18840个，收录于166种期刊。论文发表数量持续增长，年增长率达9.88%。美国、意大利和中国的文章最多。被引用最多的文章集中在昼夜节律紊乱的遗传学上。排名靠前的大学是加州大学系统、加州大学圣地亚哥分校和巴黎大学。高影响力的作者包括McClung Colleen A， McCarthy Michael J和Benedetti Francesco。h指数最高的期刊是《国际时间生物学》、《情感障碍杂志》和《美国医学遗传学杂志》。关键词共现分析显示，重点是“抑郁症”、“神经元”、“光疗”、“全基因组关联”和“锂”。一连串的关键词突出了最新的趋势，包括“睡眠”和“大脑”，并始终强调“风险”。结论：这项文献计量学分析提供了对昼夜节律基因和双相障碍研究的全球趋势和热点的见解。热点是双相障碍的症状、遗传关联和治疗，前沿探索睡眠模式、大脑功能和危险因素。

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引用次数: 0

Task-Specific Personalized Theta tACS Modulates Theta Dynamics in Associative Memory 任务特异性个性化Theta tACS调节联想记忆中的Theta动态。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71259

Busra Nur Kahraman, Mevhibe Saricaoglu, Lutfu Hanoglu

Purpose

Associative memory is fundamental to human cognition and has been strongly linked to neural oscillations in the theta frequency band. Rather than being confined to a single brain region, these processes are thought to emerge from dynamic interactions among temporal, frontal, and parietal areas, as proposed by the Temporo–Frontal–Parietal Network Model. The role of the parietal cortex plays a central and dynamic role in associative memory by supporting integrative processes that enable successful retrieval. The present study investigated whether transcranial alternating current stimulation (tACS) delivered on the left parietal cortex at individualized theta frequency (ITF) could modulate associative memory performance.

Method

Thirty healthy participants were randomly assigned to either a stimulation or sham condition. During the encoding phase of the Face and Scene Task (FAST), EEG recordings were collected. Each participant's ITF, derived from their theta activity during the encoding task, was calculated. ITF tACS was delivered over the P3 site to the stimulation group, whereas the sham group received sham stimulation. Following encoding, all participants completed a recognition task. EEG, behavioral performance, and theta activity were compared across groups.

Finding

The tACS group did not differ in recognition performance from those in the sham group. No significant effects were observed on spontaneous EEG with eyes open or directly on ITF. Time–frequency analyses revealed right-hemispheric dominance in the stimulation group and left-hemispheric dominance in the sham group within 100–400 ms. Comparisons between encoding and recognition phases suggested that stimulation modulated theta dynamics, contributing to hemispheric asymmetries.

Conclusion

The tACS at ITF can change associative memory performance, although its effects on theta activity vary across spatial and temporal dimensions. The findings suggest that ITF tACS administered during encoding is associated with improved recognition performance compared to sham, highlighting the potential of personalized stimulation approaches to support memory processing.

目的：联想记忆是人类认知的基础，与θ波段的神经振荡密切相关。正如颞额顶叶网络模型所提出的那样，这些过程不是局限于单一的大脑区域，而是从颞、额和顶叶区域之间的动态相互作用中产生的。顶叶皮层的作用在联想记忆中起着核心和动态的作用，它支持使成功检索成为可能的综合过程。本研究探讨了个体化θ波频率（ITF）下经颅交流电刺激（tACS）对左顶叶皮层联想记忆的调节作用。方法：30名健康参与者被随机分配到刺激组和假组。在Face and Scene Task （FAST）的编码阶段，采集脑电记录。每个参与者的ITF，来源于他们在编码任务中的θ活动，被计算出来。刺激组通过P3部位传递ITF - tACS，而假手术组接受假手术刺激。编码后，所有参与者都完成了一个识别任务。脑电图、行为表现和θ波活动在各组间进行比较。发现：tACS组与假手术组在识别表现上没有差异。对睁眼自发脑电图或直接对ITF无明显影响。时间-频率分析显示，在100-400 ms内，刺激组为右半球优势，假手术组为左半球优势。编码阶段和识别阶段的比较表明，刺激调节了θ动态，导致半球不对称。结论：ITF的tACS可以改变联想记忆的表现，但其对theta活动的影响在不同的时空维度上存在差异。研究结果表明，与假手术相比，在编码过程中给予ITF tACS与更好的识别性能有关，突出了个性化刺激方法支持记忆加工的潜力。

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引用次数: 0

Predicting Autism Spectrum Disorder in Children Using Glowworm Optimization With Extreme Learning Machine Networks 基于极限学习机网络的萤火虫优化预测儿童自闭症谱系障碍。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71225

Vijay Govindarajan, Ashit Kumar Dutta, Zaffar Ahmed Shaikh, Amr Yousef, Mohd Anjum, Sana Shahab

Purpose

The earlier prediction of autism spectrum disorder (ASD) placed a serious attention on ensuring the appropriate intervention to improve the child's behavioral, cognitive, and social development. The previous detection process is commonly time-intensive, subjective, and highly dependent on the clinical professions, which leads to limited accessibility in rural areas. The difficulties are addressed by introducing effective ASD detection systems, which provide a scalable, objective, and fast solution, reducing the challenges in the healthcare environment.

Method

This work integrates the Glowworm Optimization with Extreme Learning Machine Networks (GO-ELMN) model to enhance the efficiency of ASD prediction. During the analysis, ASD screening data for children are collected and processed frequently to obtain behavioral, demographic, and medical features. The extracted features are processed by an extraction learning technique, in which the network hyperparameters are optimized using the glowworm optimization algorithm. The optimized classifier recognizes children's behavior by addressing the issues of limited and imbalanced data.

Findings

The efficiency of the system is evaluated using experimental results, in which the system ensures high accuracy and convergence speed.

Conclusion

The ASD detection model provides an interpretable, fast, and reliable solution that is effectively utilized in the pediatric healthcare domain.

目的：自闭症谱系障碍（ASD）的早期预测非常重视确保适当的干预以改善儿童的行为、认知和社会发展。以前的检测过程通常是耗时的、主观的，并且高度依赖临床专业人员，这导致农村地区的可及性有限。通过引入有效的ASD检测系统来解决这些困难，该系统提供了可扩展、客观和快速的解决方案，减少了医疗保健环境中的挑战。方法：将萤火虫优化算法与极限学习机网络（GO-ELMN）模型相结合，提高ASD预测的效率。在分析过程中，经常收集和处理儿童ASD筛查数据，以获得行为、人口统计学和医学特征。提取的特征采用提取学习技术进行处理，其中网络超参数采用萤火虫优化算法进行优化。优化的分类器通过解决有限和不平衡数据的问题来识别儿童的行为。结果：通过实验结果对系统的效率进行了评价，系统保证了较高的精度和收敛速度。结论：ASD检测模型提供了一种可解释、快速、可靠的解决方案，可有效应用于儿科医疗保健领域。

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引用次数: 0

Participant Experiences of Therapeutic Touch in Psilocybin-Assisted Therapy 裸盖菇素辅助治疗中治疗性触摸的参与者体验。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71262

Rachel Ham, John Gardner, Adrian Carter, Paul Liknaitzky

Introduction

Although commonly used in psychedelic-assisted therapy, the role of therapeutic touch remains loosely defined and ethically sensitive. Gaining insight into how participants experience and interpret touch during psychedelic sessions is essential for informing safe and effective clinical practice.

Methods

Participants were sampled from a large randomized clinical trial of psilocybin-assisted therapy that permitted protocol-defined supportive touch. Longitudinal qualitative data (39 semi-structured interviews) were analyzed from n = 18 participants. Interviews covered expectations, experiences, and reflections on the use of touch during acute psychedelic states, before and after dosing. Thematic analysis was used to identify major themes.

Results

Participants expressed varied preferences and responses to therapeutic touch. Most valued its availability, particularly after firsthand experience, describing its capacity to foster emotional connection, provide grounding during intense affective states, and modulate the depth of psychedelic experience. Several reported perceiving therapeutic benefit directly attributable to touch. Acceptability was consistently linked to the quality of the therapeutic relationship and robust consent processes. Some participants also identified potential for discomfort or distraction, underscoring the need for sensitivity to individual history and context.

Conclusions

Therapeutic touch may support emotional safety and affect regulation during acute psychedelic states. Findings highlight the importance of explicit preparation, consent, and attunement when incorporating touch into psychedelic therapy. Further research should inform therapist training, individualized consent frameworks, and safety protocols to guide ethical and effective use in clinical practice.

导读：虽然通常用于迷幻辅助治疗，但治疗触摸的作用仍然定义松散，并且在伦理上敏感。深入了解参与者在迷幻过程中是如何体验和解释触摸的，对于告知安全有效的临床实践至关重要。方法：参与者从一项大型随机临床试验中取样，该试验采用裸盖菇素辅助治疗，允许协议定义的支持性触摸。从n = 18名参与者中分析纵向定性数据（39个半结构化访谈）。访谈涵盖了在急性迷幻状态下，在给药前后，对触摸使用的期望、经验和反思。专题分析用于确定主要主题。结果：参与者对治疗性触摸表现出不同的偏好和反应。大多数人看重它的可用性，特别是在亲身体验之后，描述了它促进情感联系的能力，在强烈的情感状态下提供基础，并调节迷幻体验的深度。一些人报告了直接归因于触摸的治疗效果。可接受性始终与治疗关系的质量和健全的同意过程有关。一些参与者还发现了不适或分心的可能性，强调了对个人历史和背景的敏感性的必要性。结论：治疗性触摸可能支持急性迷幻状态下的情绪安全并影响调节。研究结果强调了明确的准备，同意和调谐的重要性，当将触摸纳入致幻剂治疗。进一步的研究应该为治疗师培训、个性化同意框架和安全协议提供信息，以指导临床实践中道德和有效的使用。

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引用次数: 0

Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases 揭示共享的遗传结构和因果关系：肠道疾病和神经疾病。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71269

Ning Zhao, Shiheng Tan, Qingzhen Fu, Yanbing Li, Tian Tian, Zesong Cheng, Ding Zhang, Lijing Gao, Weiwei Bao, Depei Zhang, Zinan Li, Jinyin Liu, Liwan Wang, Zhuobo Zhang, Fan Wang, Yashuang Zhao

Background

The “gut–brain axis” provides a theoretical foundation for the connection between intestinal and neurological diseases, but whether this reflects a shared genetic etiology or causal relationships exist remains unclear.

Methods

We used genome-wide association study summary data from FinnGen and UK Biobank to investigate the genetic correlations and causal relationships between three intestinal diseases and six neurological diseases.

Results

We observed positive global genetic correlations between irritable bowel syndrome and epilepsy (r_g= 0.429, p = 1.53 × 10⁻²), and stroke (r_g= 0.368, p = 2.56×10⁻²). Upon dividing the whole genome into 1703 independent regions, local genetic correlations were identified in a region between ulcerative colitis and multiple sclerosis (Chr6: 31571218–32682664). We also identified 12 novel pleiotropic SNPs shared between intestinal and neurological diseases, as well as a functional gene shared between ulcerative colitis and multiple sclerosis. SNP heritability enrichment analysis indicated that ulcerative colitis and multiple sclerosis have enrichment in several immune cells. Two-sample Mendelian randomization indicated the causal effect of Crohn's disease on Parkinson's disease (FDR = 1.34 × 10⁻², OR = 1.092). The methylome Mendelian randomization analysis also showed causal relationships between several intestinal and neurological diseases.

Conclusions

Through comprehensive and systematic statistical analysis, we identified the global and local genetic correlations and causal relationships between several intestinal and neurological diseases and discovered shared pleiotropic loci and genes between them. Furthermore, the consistent SNP heritability enrichment observed in immune cells also indicated the crucial role of the immune system in the “gut–brain axis.”

背景：“肠脑轴”为肠道和神经系统疾病之间的联系提供了理论基础，但这是否反映了共同的遗传病因或存在因果关系尚不清楚。方法：利用FinnGen和UK Biobank的全基因组关联研究汇总数据，探讨3种肠道疾病与6种神经系统疾病之间的遗传相关性和因果关系。结果：我们观察到肠易激综合征与癫痫（rg = 0.429, p = 1.53 ×10-2）和卒中（rg = 0.368, p = 2.56×10-2）呈正相关。在将整个基因组划分为1703个独立区域后，在溃疡性结肠炎和多发性硬化症之间的区域发现了局部遗传相关性（Chr6: 31571218-32682664）。我们还发现了12个肠道和神经系统疾病之间共有的新的多效性snp，以及溃疡性结肠炎和多发性硬化症之间共有的功能基因。SNP遗传力富集分析表明，溃疡性结肠炎和多发性硬化症在几种免疫细胞中富集。双样本孟德尔随机化显示克罗恩病与帕金森病的因果关系（FDR = 1.34 × 10-2, OR = 1.092）。甲基组孟德尔随机化分析也显示了几种肠道和神经系统疾病之间的因果关系。结论：通过全面系统的统计分析，我们确定了几种肠道和神经系统疾病之间的全局和局部遗传相关性和因果关系，发现了它们之间共有的多效位点和基因。此外，在免疫细胞中观察到的一致的SNP遗传力富集也表明免疫系统在“肠-脑轴”中的关键作用。

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引用次数: 0

Identification and Verification of Anoikis-related Genes in Epilepsy Through Bioinformatics Analysis 通过生物信息学分析鉴定和验证癫痫病相关基因。

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior

Pub Date : 2026-02-16 DOI: 10.1002/brb3.71273

Haoxuan Zeng, Yanling Yuan, Tian Tan, Wenbing Zhou, Xianju Zhou, Xinhao Chen

Introduction

Epilepsy is a significant neurological disorder characterized by a complex etiology. Understanding the molecular mechanisms, notably those implicated in the immune system and anoikis, is crucial for developing targeted therapies against epilepsy.

Methods

First, two epilepsy-related transcriptomic datasets (GSE143272 and GSE4290) were selected from the GEO database; then, the differentially expressed genes (DEGs) were identified. Focusing on anoikis in epilepsy, we screened out anoikis-related genes (ARGs). Bioinformatics analysis and machine learning were employed for comprehensive analysis, and the research results were validated in an epileptic mouse model.

Results

A total of 3525 DEGs from the GSE143272 and GSE4290 datasets were identified, and a total of 24 ARGs were obtained. The five key differentially expressed ARGs (DE-ARGs) were screened through machine learning analysis, including ANKRD13C, PIK3R1, BSG, CEACAM6, and BRMS1; these DE-ARGs emerged as potential biomarkers for epilepsy and were involved in various signaling pathways and immune cell activities, and results were further experimentally validated. Besides, the risk score model based on the DE-ARGs demonstrated high diagnostic efficiency; moreover, connectivity map database analysis suggested MPEP, LY-341495, and MDL-28170 as potential therapeutic agents.

Conclusions

This study identified the five ARGs as potential therapeutic targets, highlighting the role of anoikis in epilepsy pathogenesis. Our result provides a novel insight into the molecular landscape of epilepsy and paves the way for further exploration and the development of more effective treatment strategies.

简介：癫痫是一种重要的神经系统疾病，其病因复杂。了解分子机制，特别是与免疫系统和癫痫有关的分子机制，对于开发针对癫痫的靶向治疗至关重要。方法：首先，从GEO数据库中选择两个癫痫相关转录组数据集（GSE143272和GSE4290）；然后，鉴定差异表达基因（DEGs）。针对癫痫中的嗜酸基因，我们筛选了嗜酸相关基因（ARGs）。采用生物信息学分析和机器学习进行综合分析，并在癫痫小鼠模型中对研究结果进行验证。结果：从GSE143272和GSE4290数据集中共鉴定出3525个deg，共获得24个arg。通过机器学习分析筛选5个关键差异表达ARGs (DE-ARGs)，包括ANKRD13C、PIK3R1、BSG、CEACAM6和BRMS1；这些DE-ARGs成为癫痫的潜在生物标志物，参与多种信号通路和免疫细胞活动，实验结果进一步得到验证。基于DE-ARGs的风险评分模型具有较高的诊断效率；连接图谱数据库分析提示MPEP、LY-341495和MDL-28170是潜在的治疗药物。结论：本研究确定了5种ARGs作为潜在的治疗靶点，强调了anoikis在癫痫发病机制中的作用。我们的研究结果为癫痫的分子格局提供了新的视角，为进一步探索和开发更有效的治疗策略铺平了道路。

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引用次数: 0