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Combining Quantitative Susceptibility Mapping With the Gray Matter Volume to Predict Neurological Deficits in Patients With Small Artery Occlusion 将定量易感性图谱与灰质体积相结合预测小动脉闭塞患者的神经功能缺陷
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-10-04 DOI: 10.1002/brb3.70080
Xuelian Tang, Zhenzhen He, Qian Yang, Tao Yang, Yusheng Yu, Jinan Chen

Background

Currently, there is still a lack of valuable neuroimaging markers to assess the clinical severity of stroke patients with small artery occlusion (SAO). Quantitative susceptibility mapping (QSM) is a quantitative processing method for neuroradiological diagnostics. Gray matter (GM) volume changes in stroke patients are also proved to be associated with neurological deficits. This study aims to explore the predictive value of QSM and GM volume in neurological deficits of patients with SAO.

Methods

As neurological deficits, the National Institutes of Health Stroke Scale (NIHSS) was used. Sixty-six SAO participants within 24 h of first onset were enrolled and divided into mild and moderate groups based on NIHSS. QSM values of infarct area and GM volume were calculated from magnetic resonance imaging (MRI) data. Two-sample t-tests were used to compare differences in QSM value and GM volume between the two groups, and the diagnostic efficacy of the combination of QSM value and GM volume was evaluated.

Results

The results revealed both the QSM value and GM volume within the infarct area of the moderate group were lower compared to the mild group. Moderate group exhibited lower GM volume in some specific gyrus compared with mild group in the case of voxel-wise GM volume on whole-brain voxel level. The support vector machine (SVM) classifier's analysis showed a high power for the combination of QSM value, GM volume within the infarct area, and voxel-wise GM volume.

Conclusion

Our research first reported the combination of QSM value, GM volume within the infarct area, and voxel-wise GM volume could be used to predict neurological impairment of patients with SAO, which provides new insights for further understanding the SAO stroke.

背景:目前,仍缺乏有价值的神经影像标志物来评估小动脉闭塞(SAO)脑卒中患者的临床严重程度。定量易感图(QSM)是神经放射诊断的一种定量处理方法。中风患者的灰质(GM)体积变化也被证明与神经功能缺损有关。本研究旨在探讨 QSM 和 GM 体积对 SAO 患者神经功能缺损的预测价值:神经功能缺损采用美国国立卫生研究院卒中量表(NIHSS)。根据 NIHSS 将首次发病 24 小时内的 66 名 SAO 患者分为轻度组和中度组。根据磁共振成像(MRI)数据计算梗死面积和GM体积的QSM值。采用双样本 t 检验比较两组间 QSM 值和 GM 体积的差异,并评估 QSM 值和 GM 体积组合的诊断效果:结果显示,中度组的 QSM 值和梗死区内的 GM 体积均低于轻度组。在全脑体素GM体积方面,中度组某些特定脑回的GM体积低于轻度组。支持向量机(SVM)分类器的分析表明,QSM 值、梗死区内的 GM 体积和全脑体素 GM 体积的组合具有很高的预测能力:我们的研究首次报道了QSM值、梗死区内GM体积和体素GM体积的组合可用于预测SAO患者的神经功能损伤,这为进一步了解SAO卒中提供了新的见解。
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引用次数: 0
Comparison of Clinical Effects and Physical Examination of Transforaminal and Caudal Steroid Injection With Targeted Catheter in Lumbar Radiculopathy: A Single-Blind Randomized Clinical Trial 使用靶向导管经椎间孔注射类固醇与经尾椎注射类固醇治疗腰椎病的临床效果和体格检查比较:单盲随机临床试验。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-10-04 DOI: 10.1002/brb3.70067
Farnad Imani, Faezeh Mohammad-Esmaeel, Seyedeh-Fatemeh Morsalli, Ali Ahani-Azari, Mahzad Alimian, Nasim Nikoubakht, Azadeh Emami

Background

Transforaminal and caudal epidural injections are two methods of steroid injection in lumbar radiculopathy. Using a targeted catheter with the possibility of accessing the involved spinal roots and steroid administration selectively next to them during the caudal procedure may achieve the benefits of both transforaminal and caudal procedures. The aim of this study was to investigate the clinical effects and physical examinations of transforaminal steroid injection compared to caudal through a targeted catheter in lumbar radiculopathy.

Methods

Fifty patients with lumbar radiculopathy candidates for epidural steroid injection were divided into transforaminal (T) and caudal (C) groups. Steroid injection under fluoroscopic guidance was performed in group T with the transforaminal method and in group C with the caudal method using a targeted catheter for each involved spinal nerve root. Pain intensity visual analog scale (VAS), Oswestry Disability Index (ODI), daily analgesic consumption, and physical examinations on four follow-ups (before injection, second week, first and third month) were evaluated.

Results

Pain score (VAS) and functional disability index (ODI) were similar in both groups, and there was no significant difference between the two groups (p > 0.05). The positive Lasègue test was significantly higher in the caudal group than in the transforaminal group only in the third month (p < 0.05). Other physical examinations in both groups did not have significant differences in all the follow-ups. Moreover, there was no difference in the amount of analgesic consumption in the two groups. No complications were observed in both groups.

Conclusion

This study showed that transforaminal and caudal steroid injection (with a targeted catheter) in patients with lumbar radiculopathy had similar effects in controlling pain and improving functional disability of patients in the short term. Cases of recurrence of positive Lasègue test in physical examinations in the long term (third month) in the caudal group may indicate the preference of the transforaminal approach.

Trial Registration

Iranian Registry of Clinical Trials (IRCT) number: IRCT20111102007984N31

背景:经椎间孔和尾部硬膜外注射是腰椎病的两种类固醇注射方法。使用靶向导管可进入受累椎弓根,并在尾部注射过程中选择性地在椎弓根旁注射类固醇,可实现经椎间孔和尾部注射两种方法的优点。本研究旨在探讨腰椎病患者经椎间孔注射类固醇与通过靶向导管经尾部注射类固醇的临床效果和体格检查:方法:将50名腰椎病患者分为经椎间孔组(T组)和经尾骨组(C组)。在透视引导下,T 组采用经椎间孔法注射类固醇,C 组采用尾侧法,在每个受累脊神经根处使用靶向导管。对四次随访(注射前、第二周、第一个月和第三个月)的疼痛强度视觉模拟量表(VAS)、Oswestry 残疾指数(ODI)、每日镇痛剂用量和体格检查进行了评估:结果:两组患者的疼痛评分(VAS)和功能障碍指数(ODI)相似,无明显差异(P>0.05)。仅在第三个月,尾椎组的 Lasègue 试验阳性率明显高于经椎间孔组(P 结论:经椎间孔组的疼痛评分和功能障碍指数均低于尾椎组(P>0.05):本研究表明,腰椎病患者接受经椎间孔注射和尾部注射类固醇(使用靶向导管)在短期内控制疼痛和改善患者功能障碍方面的效果相似。在长期(第三个月)体格检查中,尾侧组再次出现 Lasègue 试验阳性的病例,这可能表明经椎间孔方法更受青睐:伊朗临床试验注册中心(IRCT)编号:IRCT20111102007984N31。
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引用次数: 0
Danggui Shaoyao San Alleviates Early Cognitive Impairment in Alzheimer's Disease Mice Through IRS1/GSK3β/Wnt3a-β-Catenin Pathway 当归芍药散通过IRS1/GSK3β/Wnt3a-β-Catenin通路缓解阿尔茨海默病小鼠的早期认知功能障碍
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70056
Kai-Xin Zhang, Ning Sheng, Peng-Li Ding, Ji-Wei Zhang, Xiang-Qing Xu, Ya-Han Wang

Introduction

Alzheimer's disease (AD) is a neurodegenerative disease characterized by Amyloid plaques and neurofibrillary tangles. We explored the potential mechanism by which Danggui Shaoyao San (DSS) modulates central glucose metabolism via the insulin receptor substrate 1 (IRS1)/glycogen synthase kinase-3β (GSK3β)/Wnt3a-β-catenin pathway, thereby exerting protective effects on cognitive functions.

Methods

In vitro, HT22 cells were induced with streptozotocin (STZ) to investigate the impact of GSK3β on pathway transduction. The active components in the DSS stock solution were validated using mass spectrometry. Subsequently, an AD model in C57BL/6J mice was established through STZ injection into both ventricles. The success of the model was validated behaviorally and pathologically. The Morris Water Maze (MWM) test, immunohistochemistry, Western blotting, quantitative reverse transcription-PCR, and 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) were employed to evaluate the influence of DSS on memory and pathological changes in AD.

Results

The DSS stock solution, rich in active components, ameliorated the memory deficits in AD mice in the MWM. In vitro, GSK3β exhibited regulatory control over Wnt and β-catenin, with GSK3β inhibition mitigating β-amyloid and tau redundancies at protein and gene levels, facilitating signal transduction. In vivo, DSS impacted key targets in the IRS1/GSK3β/Wnt3a-β-catenin pathway, mitigated senile plaques resulting from amyloid β (Aβ) deposition and neurofiber tangles induced by tau hyperphosphorylation, and alleviated the decline in central glucose metabolism observed in FDG-PET.

Conclusions

Our findings suggest that DSS potentially confers cognitive protection by alleviating central hypoglycemia through the IRS1/GSK3β/Wnt3a-β-catenin pathway. This may serve as a promising therapeutic avenue for AD.

导言阿尔茨海默病(AD)是一种以淀粉样蛋白斑块和神经纤维缠结为特征的神经退行性疾病。我们探讨了当归芍药散(DSS)通过胰岛素受体底物1(IRS1)/糖原合成酶激酶-3β(GSK3β)/Wnt3a-β-catenin通路调节中枢糖代谢,从而对认知功能产生保护作用的潜在机制:在体外,用链脲佐菌素(STZ)诱导 HT22 细胞,研究 GSK3β 对通路转导的影响。质谱法验证了DSS储备液中的活性成分。随后,通过向C57BL/6J小鼠的两个脑室注射STZ,建立了AD模型。该模型的成功通过了行为学和病理学验证。采用莫里斯水迷宫(MWM)试验、免疫组化、Western印迹、定量反转录-PCR和18F-氟脱氧葡萄糖-正电子发射断层扫描(FDG-PET)来评估DSS对AD记忆和病理变化的影响:结果:富含活性成分的DSS储备液改善了AD小鼠在MWM中的记忆缺陷。在体外,GSK3β对Wnt和β-catenin具有调控作用,抑制GSK3β可减轻蛋白质和基因水平上的β-淀粉样蛋白和tau冗余,促进信号转导。在体内,DSS影响了IRS1/GSK3β/Wnt3a-β-catenin通路中的关键靶点,减轻了淀粉样β(Aβ)沉积导致的老年斑和tau过度磷酸化诱导的神经纤维缠结,并缓解了FDG-PET观察到的中枢葡萄糖代谢下降:我们的研究结果表明,DSS可通过IRS1/GSK3β/Wnt3a-β-catenin途径缓解中枢性低血糖,从而保护认知能力。这可能会成为一种很有前景的注意力缺失症治疗方法。
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引用次数: 0
Monocyte-to-Albumin Ratio Is Associated With Hematoma Expansion in Spontaneous Intracerebral Hemorrhage 单核细胞与白蛋白比率与自发性脑出血血肿扩大有关
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70059
Jie Fu, Yilin Xu, Xiu Chen, Jinglun Li, Lilei Peng

Background

Hematoma expansion (HE) after spontaneous intracerebral hemorrhage (ICH) is a severe complication that independently predicts poor prognosis. In this study, we aimed to investigate whether monocyte-to-albumin ratio (MAR), a novel marker of systemic inflammation, could predict HE in patients with ICH.

Methods

We retrospectively assessed the data of patients with ICH. The clinical, imaging, and laboratory test data including, the MAR on admission, were analyzed. A multivariate logistic regression analysis was carried out to explore the relationship between MAR and hematoma growth. The receiver operating characteristic (ROC) curve was employed to investigate the predictive value of MAR for HE after ICH.

Results

A total of 246 patients were included in the present study. Multivariate logistic regression analysis demonstrated that the MAR was associated with HE (odds ratio [OR] = 1.179; 95% confidence interval, 1.093–1.272; p = 0.000). ROC curve analysis showed that MAR could predict HE, with an area under the curve of 0.802 (95% CI: 0.744–0.859, < 0.001). The optimal predictive cutoff value of MAR for HE was 10.01 (sensitivity: 72.43%, specificity: 77.05%).

Conclusions

Our results suggested that a high MAR on admission was associated with an increased risk of HE in ICH patients, and MAR can become an independent predictor of HE in ICH patients.

背景:自发性脑出血(ICH)后血肿扩大(HE)是一种严重的并发症,可独立预测不良预后。本研究旨在探讨单核细胞与白蛋白比值(MAR)这一全身炎症的新型标志物能否预测 ICH 患者的血肿扩大:我们对 ICH 患者的数据进行了回顾性评估。方法:我们对 ICH 患者的数据进行了回顾性评估,分析了临床、影像学和实验室检查数据,包括入院时的 MAR。我们进行了多变量逻辑回归分析,以探讨 MAR 与血肿生长之间的关系。采用接收者操作特征曲线(ROC)研究 MAR 对 ICH 后 HE 的预测价值:本研究共纳入 246 例患者。多变量逻辑回归分析表明,MAR 与 HE 相关(几率比 [OR] = 1.179;95% 置信区间,1.093-1.272;P = 0.000)。ROC 曲线分析表明,MAR 可以预测 HE,其曲线下面积为 0.802(95% CI:0.744-0.859,p 结论:MAR 与 HE 的相关性较低:我们的研究结果表明,入院时的高MAR与ICH患者发生高血压的风险增加有关,MAR可成为ICH患者发生高血压的独立预测指标。
{"title":"Monocyte-to-Albumin Ratio Is Associated With Hematoma Expansion in Spontaneous Intracerebral Hemorrhage","authors":"Jie Fu,&nbsp;Yilin Xu,&nbsp;Xiu Chen,&nbsp;Jinglun Li,&nbsp;Lilei Peng","doi":"10.1002/brb3.70059","DOIUrl":"10.1002/brb3.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hematoma expansion (HE) after spontaneous intracerebral hemorrhage (ICH) is a severe complication that independently predicts poor prognosis. In this study, we aimed to investigate whether monocyte-to-albumin ratio (MAR), a novel marker of systemic inflammation, could predict HE in patients with ICH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively assessed the data of patients with ICH. The clinical, imaging, and laboratory test data including, the MAR on admission, were analyzed. A multivariate logistic regression analysis was carried out to explore the relationship between MAR and hematoma growth. The receiver operating characteristic (ROC) curve was employed to investigate the predictive value of MAR for HE after ICH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 246 patients were included in the present study. Multivariate logistic regression analysis demonstrated that the MAR was associated with HE (odds ratio [OR] = 1.179; 95% confidence interval, 1.093–1.272; <i>p</i> = 0.000). ROC curve analysis showed that MAR could predict HE, with an area under the curve of 0.802 (95% CI: 0.744–0.859, <i>p </i>&lt; 0.001). The optimal predictive cutoff value of MAR for HE was 10.01 (sensitivity: 72.43%, specificity: 77.05%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggested that a high MAR on admission was associated with an increased risk of HE in ICH patients, and MAR can become an independent predictor of HE in ICH patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic corticosterone enhances fear memory extinction in rats: Involvement of the infralimbic medial prefrontal cortex GABAA and GABAB receptors 全身皮质酮可增强大鼠的恐惧记忆消退:下边缘内侧前额叶皮层 GABAA 和 GABAB 受体的参与。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70043
Samira Omoumi, Ali Rashidy-Pour, Seyed Ali Seyedinia, Parnia Tarahomi, Katayoun Sedaghat, Abbas Ali Vafaei, Payman Raise-Abdullahi

Purpose

The infralimbic (IL) subregion of the medial prefrontal cortex (mPFC) regulates the extinction of conditioned fear memory. Glucocorticoid and gamma-aminobutyric acid (GABA) receptors are expressed in the mPFC and are also critical in fear extinction. This study investigated the possible interactive effects of the glucocorticoids and GABAergic system in the IL on the regulation of fear extinction.

Method

The rats were trained using an auditory fear conditioning task during which they received three conditioned stimuli (tones, 30 s, 4 kHz, 80 dB), co-terminated with the three unconditioned stimuli (footshock, 0.8 mA, 1 s). Extinction testing was conducted over 3 days (Ext 1–3). Thirty minutes before the first extinction trial (Ext 1), the rats received bicuculline (BIC, 1 mg/kg/2 mL, intraperitoneal [i.p.]) as a GABAA receptor antagonist or CGP55845 (CGP, 0.1 mg/kg/2 ML, i.p.) as a GABAB receptor antagonist followed by systemic injection of corticosterone (CORT, 3 mg/kg/2 ML, i.p.). Furthermore, separate groups of rats received a bilateral intra-IL injection of BIC (100 ng/0.3 µL/side) or CGP (10 ng/0.3 µL/side) followed by a systemic injection of CORT (3 mg/kg/2 ML, i.p.) before the first extinction trial (Ext 1). The extracellular signal-regulated kinase (ERK1) and cAMP response element-binding (CREB) activity in the IL was examined by Western blot analysis after Ext 1.

Finding

The results indicated that systemic CORT injection facilitated fear extinction and increased the expression of ERK1 but not CREB in the IL. Both systemic and intra-IL co-injection of BIC or CGP blocked the effects of CORT on fear extinction and ERK1 expression.

Conclusion

These findings suggest that glucocorticoids and the GABAergic system may modulate fear extinction through the ERK pathway in the IL.

目的:内侧前额叶皮层(mPFC)的下边缘(IL)亚区调节条件性恐惧记忆的消退。糖皮质激素和γ-氨基丁酸(GABA)受体表达于内侧前额叶皮层,在恐惧消退中也起着关键作用。本研究探讨了IL中糖皮质激素和GABA能系统对恐惧消退调节可能产生的交互作用:方法:对大鼠进行听觉恐惧条件反射训练,在此期间,大鼠接受三个条件刺激(音调,30秒,4千赫兹,80分贝),并与三个非条件刺激(脚震,0.8毫安,1秒)共同终止。消退测试分 3 天进行(Ext 1-3)。在第一次消退试验(Ext 1)前 30 分钟,大鼠腹腔注射 GABAA 受体拮抗剂双谷氨酸(BIC,1 mg/kg/2 mL,i.p.)或 GABAB 受体拮抗剂 CGP55845(CGP,0.1 mg/kg/2 ML,i.p.),然后全身注射皮质酮(CORT,3 mg/kg/2 ML,i.p.)。此外,在第一次绝迹试验(Ext 1)之前,各组大鼠分别接受了双侧 BIC(100 纳克/0.3 微升/侧)或 CGP(10 纳克/0.3 微升/侧)IL 内注射,然后全身注射 CORT(3 毫克/千克/2 毫升,静注)。Ext 1结束后,通过Western印迹分析检测了IL中细胞外信号调节激酶(ERK1)和cAMP反应元件结合(CREB)的活性:结果表明,全身注射 CORT 可促进恐惧消退,并增加 IL 中 ERK1 的表达,但不增加 CREB 的表达。全身和 IL 内联合注射 BIC 或 CGP 均阻断了 CORT 对恐惧消退和 ERK1 表达的影响:这些研究结果表明,糖皮质激素和 GABA 能系统可通过 IL 中的 ERK 通路调节恐惧消退。
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引用次数: 0
Apathy and Impulsivity Co-Occur in Huntington's Disease 亨廷顿舞蹈症患者同时出现冷漠和冲动症状
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70061
Lee-Anne Morris, Kyla-Louise Horne, Laura Paermentier, Christina M. Buchanan, Michael MacAskill, Daniel Myall, Masud Husain, Richard Roxburgh, Tim Anderson, Campbell Le Heron

Background

Apathy is a debilitating behavioral change in Huntington's disease (HD), but impulsivity in HD has not been well documented, and the co-occurrence of these behaviors in HD has not been investigated.

Objective

Our objective was to determine whether apathy and impulsivity co-occur in people with HD and their associations with quality of life.

Methods

Carriers of Huntington's gene expansion (premanifest to mild motor manifest disease; = 42) along with healthy controls (= 20) completed measures of apathy (Apathy Evaluation Scale and Apathy Motivation Index) and impulsivity (Barratt Impulsiveness Scale-11 and UPPS-P impulsivity scale), along with mood, cognition, clinical, and quality of life measures. Apathy and impulsivity measures were each reduced to a single metric per patient using principal component analysis. Correlations and multiple linear regression models determined associations between apathy and impulsivity and the potential influence of other covariates.

Results

Apathy and impulsivity were significantly correlated (= 0.6, < 0.001, 95% CI [0.36, 0.76]) in HD, with this association remaining after controlling for depressive symptoms, motor disease severity, and cognitive function. Furthermore, apathy and depressive symptoms were associated with poorer quality of life.

Conclusions

Apathy and impulsivity co-occur in individuals with premanifest to mild manifest HD and have a significant impact on wellbeing. We add to a growing evidence body that apathy and impulsivity may be intrinsically linked.

背景:冷漠是亨廷顿氏病(HD)中一种使人衰弱的行为变化,但HD中的冲动行为还没有被很好地记录下来,而且这些行为在HD中是否同时存在还没有被研究过:我们的目的是确定在 HD 患者中是否同时存在冷漠和冲动行为,以及它们与生活质量的关系:亨廷顿基因扩增携带者(显性前至轻度运动显性疾病;n = 42)和健康对照组(n = 20)完成了冷漠(冷漠评估量表和冷漠动机指数)和冲动(巴拉特冲动量表-11和UPPS-P冲动量表)测量,以及情绪、认知、临床和生活质量测量。采用主成分分析法将每位患者的冷漠和冲动测量值简化为单一指标。相关性和多元线性回归模型确定了冷漠和冲动之间的关联以及其他协变量的潜在影响:结果:冷漠和冲动之间存在明显的相关性(r = 0.6,p 结论:冷漠和冲动共存:冷漠和冲动同时存在于表现前至轻度表现型 HD 患者中,并对其健康状况产生重大影响。越来越多的证据表明,冷漠和冲动可能存在内在联系,我们的研究为这一观点增添了新的证据。
{"title":"Apathy and Impulsivity Co-Occur in Huntington's Disease","authors":"Lee-Anne Morris,&nbsp;Kyla-Louise Horne,&nbsp;Laura Paermentier,&nbsp;Christina M. Buchanan,&nbsp;Michael MacAskill,&nbsp;Daniel Myall,&nbsp;Masud Husain,&nbsp;Richard Roxburgh,&nbsp;Tim Anderson,&nbsp;Campbell Le Heron","doi":"10.1002/brb3.70061","DOIUrl":"10.1002/brb3.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Apathy is a debilitating behavioral change in Huntington's disease (HD), but impulsivity in HD has not been well documented, and the co-occurrence of these behaviors in HD has not been investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our objective was to determine whether apathy and impulsivity co-occur in people with HD and their associations with quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Carriers of Huntington's gene expansion (premanifest to mild motor manifest disease; <i>n </i>= 42) along with healthy controls (<i>n </i>= 20) completed measures of apathy (Apathy Evaluation Scale and Apathy Motivation Index) and impulsivity (Barratt Impulsiveness Scale-11 and UPPS-P impulsivity scale), along with mood, cognition, clinical, and quality of life measures. Apathy and impulsivity measures were each reduced to a single metric per patient using principal component analysis. Correlations and multiple linear regression models determined associations between apathy and impulsivity and the potential influence of other covariates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Apathy and impulsivity were significantly correlated (<i>r </i>= 0.6, <i>p </i>&lt; 0.001, 95% CI [0.36, 0.76]) in HD, with this association remaining after controlling for depressive symptoms, motor disease severity, and cognitive function. Furthermore, apathy and depressive symptoms were associated with poorer quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Apathy and impulsivity co-occur in individuals with premanifest to mild manifest HD and have a significant impact on wellbeing. We add to a growing evidence body that apathy and impulsivity may be intrinsically linked.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder 基于表面形态测量的疑似特发性快速眼动睡眠行为障碍患者大脑皮层分析。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70057
Milad Najafzadeh, Athareh Saeeidian-Mehr, Hossein Akbari-Lalimi, Zohre Ganji, Shahrokh Nasseri, Hoda Zare, Luigi Ferini-Strambi

Introduction

Strong indications support the notion that idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) acts as a precursor to multiple α-synucleinopathies, including Parkinson's disease and dementia with Lewy bodies. Despite numerous investigations into the alterations in cortical thickness and the volume of subcortical areas associated with this condition, comprehensive studies on the cortical surface morphology, focusing on gyrification and sulcal depth changes, are scarce. The purpose of this research was to explore the cortical surface morphology in individuals with probable iRBD (piRBD), to pinpoint early-phase diagnostic markers.

Methods

This study included 30 piRBD patients confirmed using the RBD Screening Questionnaire (RBDSQ) and 33 control individuals selected from the Parkinson's Progression Markers Initiative (PPMI) database. They underwent neurophysiological tests and MRI scans. The FreeSurfer software was utilized to estimate cortical thickness (CTH), cortical and subcortical volumetry, local gyrification index (LGI), and sulcus depth (SD). Subsequently, these parameters were compared between the two groups. Additionally, linear correlation analysis was employed to estimate the relationship between brain morphological parameters and clinical parameters.

Results

Compared to the healthy control (HC), piRBD patients exhibited a significant reduction in CTH, LGI, and cortical volume in the bilateral superior parietal, lateral occipital, orbitofrontal, temporo-occipital, bilateral rostral middle frontal, inferior parietal, and precentral brain regions. Moreover, a significant and notable correlation was observed between CTH and Geriatric Depression Scale (GDS), letter–number sequencing (LTNS), the Benton Judgment of Line Orientation (BJLO) test, and the symbol digit modalities test (SDMT) in several brain regions encompassing the motor cortex.

Conclusion

Patients with piRBD displayed widespread atrophy in various brain regions, predominantly covering the motor and sensory cortex. Furthermore, LGI could serve as a prognostic biomarker of disease's progression in piRBD.

导言:有确凿证据表明,特发性快速眼动(REM)睡眠行为障碍(iRBD)是包括帕金森病和路易体痴呆在内的多种α-突触核蛋白病的前兆。尽管对与这种疾病相关的皮质厚度和皮质下区域体积的改变进行了大量研究,但以回化和沟深度变化为重点的皮质表面形态的全面研究却很少。本研究的目的是探讨可能患有 iRBD(piRBD)的个体的皮质表面形态,以确定早期诊断标志物:这项研究包括30名使用RBD筛查问卷(RBDSQ)确诊的piRBD患者和33名从帕金森病进展标志物倡议(PPMI)数据库中挑选的对照者。他们接受了神经电生理测试和核磁共振成像扫描。利用 FreeSurfer 软件估算皮质厚度 (CTH)、皮质和皮质下容积、局部回旋指数 (LGI) 和沟深度 (SD)。随后,将这些参数在两组之间进行比较。此外,还采用线性相关分析来估计大脑形态学参数与临床参数之间的关系:结果:与健康对照组(HC)相比,piRBD患者的CTH、LGI以及双侧上顶叶、外侧枕叶、眶额叶、颞枕叶、双侧喙中额叶、下顶叶和前中央区的皮质体积均显著减少。此外,CTH与老年抑郁量表(GDS)、字母-数字排序(LTNS)、Benton直线定向判断(BJLO)测试和符号数字模型测试(SDMT)之间也存在明显的相关性:结论:piRBD 患者的多个脑区出现广泛萎缩,主要包括运动皮层和感觉皮层。此外,LGI可作为piRBD疾病进展的预后生物标志物。
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引用次数: 0
The volumes of amygdala subregions and peripheral programmed cell death protein-1 levels are associated with cognitive decline in individuals with knee osteoarthritis 杏仁核亚区的体积和外周程序性细胞死亡蛋白-1的水平与膝骨关节炎患者的认知能力下降有关。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70042
Peiling Zeng, Baoru Zhao, Ming Li, Yajun Wang, Guiyan Cai, Ruilin Chen, Lidian Chen, Jiao Liu

Background

Persistent pain is a prominent symptom of knee osteoarthritis (KOA) and has been associated with cognitive decline in individuals with KOA. The amygdala, a complex structure consisting of nine subnuclei, and programmed cell death protein-1 (PD-1) levels play crucial roles in pain regulation and cognitive processing. This study aims to investigate the relationships among amygdala subregion volumes, cognitive function, and PD-1 levels to elucidate the underlying mechanism of cognitive decline in KOA.

Methods

In this cross-sectional study, we recruited 36 patients with KOA and 25 age/gender-matched healthy controls for neuropsychological tests, structural magnetic resonance imaging scanning, and measurement of serum PD-1 levels. We used the atlas provided by FreeSurfer software to automatically segment the amygdala subnuclei. Subsequently, we compared the volumes of amygdala subregions between groups and explored their correlation with clinical scores and PD-1 levels.

Results

Compared to healthy controls, individuals with KOA exhibited significantly lower scores on global cognition tasks, such as long-delay free recall, short-delay free recall, and immediate recall tasks. Moreover, they displayed decreased volumes in lateral nucleus basal nucleus paralaminar nucleus while showing increased volumes in accessory basal nucleus, central nucleus, medial nucleus, and cortical nucleus. Within the KOA group specifically, paralaminar volume was negatively correlated with immediate recall scores; pain scores were negatively correlated with global cognition; basal volume was negatively correlated with PD-1 levels.

Conclusion

Our findings highlight those alterations in amygdala subregion volumes along with changes in serum PD-1 levels may contribute to observe cognitive decline among individuals suffering from KOA.

背景:持续疼痛是膝关节骨性关节炎(KOA)的一个突出症状,并且与 KOA 患者的认知能力下降有关。杏仁核是一个由九个亚核组成的复杂结构,其程序性细胞死亡蛋白-1(PD-1)水平在疼痛调节和认知处理过程中起着至关重要的作用。本研究旨在探讨杏仁核亚区体积、认知功能和PD-1水平之间的关系,以阐明KOA患者认知功能下降的潜在机制:在这项横断面研究中,我们招募了 36 名 KOA 患者和 25 名年龄/性别匹配的健康对照者,对他们进行了神经心理学测试、结构性磁共振成像扫描和血清 PD-1 水平测定。我们使用FreeSurfer软件提供的图谱自动分割杏仁核亚核。随后,我们比较了不同组间杏仁核亚区的体积,并探讨了它们与临床评分和PD-1水平的相关性:结果:与健康对照组相比,KOA 患者在全局认知任务(如长延时自由回忆、短延时自由回忆和即时回忆任务)上的得分明显较低。此外,他们的外侧核、基底核、副基底核、中央核、内侧核和皮层核体积减少,而附属基底核、中央核、内侧核和皮层核体积增加。特别是在 KOA 组中,髓旁核体积与即时回忆评分呈负相关;疼痛评分与整体认知呈负相关;基底核体积与 PD-1 水平呈负相关:我们的研究结果表明,杏仁核亚区体积的变化以及血清 PD-1 水平的变化可能会导致观察到的 KOA 患者认知能力下降。
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引用次数: 0
Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization 大脑成像特征与癫痫:通过 "泯灭随机化 "揭示因果联系。
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70051
Fangyan Li, Maowen Tang, Cheng Hao, Menghua Yang, Yue Pan, Pinggui Lei

Background

Epilepsy, a complex neurological disorder, is closely linked with structural and functional irregularities in the brain. However, the causal relationship between brain imaging-derived phenotypes (IDPs) and epilepsy remains unclear. This study aimed to investigate this relationship by employing a two-sample bidirectional Mendelian randomization (MR) approach.

Methods

The analysis involved 3935 cerebral IDPs from the UK Biobank and all documented cases of epilepsy (all epilepsies) cohorts from the International League Against Epilepsy, with further validation through replication and meta-analyses using epilepsy Genome-Wide Association Studies datasets from the FinnGen database. Additionally, a multivariate MR analysis framework was utilized to assess the direct impact of IDPs on all epilepsies. Furthermore, we performed a bidirectional MR analysis to investigate the relationship between the IDPs identified in all epilepsies and the 15 specific subtypes of epilepsy.

Results

The study identified significant causal links between four IDPs and epilepsy risk. Decreased fractional anisotropy in the left inferior longitudinal fasciculus was associated with a higher risk of epilepsy (odds ratio [OR]: 0.89, p = 3.31×10−5). Conversely, increased mean L1 in the left posterior thalamic radiation (PTR) was independently associated with a heightened epilepsy risk (OR: 1.14, p = 4.72×10−5). Elevated L3 in the left cingulate gyrus was also linked to an increased risk (OR: 1.09, p = .03), while decreased intracellular volume fraction in the corpus callosum was correlated with higher epilepsy risk (OR: 0.94, p = 1.15×10−4). Subtype analysis revealed that three of these IDPs are primarily associated with focal epilepsy (FE). Notably, increased L1 in the left PTR was linked to an elevated risk of hippocampal sclerosis (HS) and lesion-negative FE, whereas elevated L3 in the left cingulate gyrus was associated with HS-related FE.

Conclusions

Our research offers genetic evidence for a causal link between brain IDPs and epilepsy. These results enhance our understanding of the structural brain changes associated with the onset and progression of epilepsy.

背景:癫痫是一种复杂的神经系统疾病,与大脑结构和功能异常密切相关。然而,脑成像衍生表型(IDPs)与癫痫之间的因果关系仍不清楚。本研究旨在通过双样本双向孟德尔随机化(MR)方法研究这种关系:分析涉及英国生物库(UK Biobank)的3935例脑IDP和国际抗癫痫联盟(International League Against Epilepsy)的所有记录在案的癫痫病例(所有癫痫)队列,并通过使用FinnGen数据库的癫痫全基因组关联研究数据集进行复制和荟萃分析进一步验证。此外,我们还利用多变量 MR 分析框架来评估 IDPs 对所有癫痫的直接影响。此外,我们还进行了双向磁共振分析,研究在所有癫痫中发现的IDPs与15种特定癫痫亚型之间的关系:研究发现了四种 IDP 与癫痫风险之间的重要因果关系。左下纵筋束分数各向异性降低与癫痫风险较高有关(几率比 [OR]:0.89,P = 3.31×10-5)。相反,左丘脑后辐射(PTR)平均 L1 的增加与癫痫风险的增加有独立关联(OR:1.14,p = 4.72×10-5)。左侧扣带回的 L3 升高也与风险增加有关(OR:1.09,p = .03),而胼胝体的细胞内体积分数降低与癫痫风险增加有关(OR:0.94,p = 1.15×10-4)。亚型分析表明,其中三种 IDP 主要与局灶性癫痫(FE)有关。值得注意的是,左侧PTR的L1增高与海马硬化(HS)和病变阴性FE的风险升高有关,而左侧扣带回的L3增高与HS相关的FE有关:我们的研究为大脑 IDPs 与癫痫之间的因果关系提供了遗传学证据。这些结果加深了我们对与癫痫发病和进展相关的大脑结构变化的理解。
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引用次数: 0
Diagnostic Value of Serum Apolipoprotein B100 Combined With Hippocampal Volume in Alzheimer's Disease 血清载脂蛋白 B100 结合海马体体积对阿尔茨海默氏症的诊断价值
IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Pub Date : 2024-09-30 DOI: 10.1002/brb3.70066
Dandan Zhang, Jing Wu, Guoqiang Ren, Yi Wang, Hang Xu, Siyuan Chen, Xuezhong Li, Xiaopeng Chen

Purpose

To explore the diagnostic value of serum apolipoprotein B100 (Apo B100) combined with hippocampal volume in Alzheimer's disease (AD).

Methods

A total of 59 AD patients and 59 healthy subjects were selected. The Mini-Mental State Examination (MMSE) was used for neuropsychological assessment. Blood glucose and serum lipid levels were detected by biochemical analyzer. Polymerase chain reaction (PCR) was used to detect apolipoprotein E (Apo E) ε3/ε4 genotypes in the plasma. Hippocampal volume was calculated using Slicer software. Independent-sample t test or Mann–Whitney U test were used to compare the levels of various indicators between the two groups. Spearman's correlation analysis was used to analyze the correlation between each level. The receiver operating characteristic curve (ROC) was plotted, and the area under the curve (AUC) was calculated to compare the diagnostic efficacy of individual and combined detection of serum Apo B100 levels and hippocampal volume in AD.

Results

Compared with the healthy control group, the levels of serum total cholesterol (TC), low-density lipoprotein (LDL), Apo B100, and plasma Apo E ε3/ε4 were higher in the AD group, and serum high-density lipoprotein (HDL) level was lower in the AD group (both < 0.05). The hippocampal volume in the AD group was lower than in the control group (< 0.01). The serum Apo B100 level was negatively correlated with MMSE score (r = −0.646), whereas hippocampal volume was positively correlated with MMSE score (= 0.630). ROC curve analysis showed that the AUC of the combined serum Apo B100 level and hippocampal volume for AD was higher than that of either alone (AUC = 0.821, < 0.01).

Conclusion

Serum Apo B100 level is elevated, and the hippocampal volume is reduced in AD patients. The combined detection of the two has a higher diagnostic efficiency for AD than other alone and has the potential to become an important indicator for the diagnosis of AD in the future.

目的:探讨血清载脂蛋白B100(Apo B100)结合海马体积对阿尔茨海默病(AD)的诊断价值:方法:选取59名阿尔茨海默病患者和59名健康受试者。方法:共选取 59 名 AD 患者和 59 名健康受试者,采用迷你精神状态检查(MMSE)进行神经心理评估。生化分析仪检测血糖和血脂水平。聚合酶链反应(PCR)用于检测血浆中载脂蛋白E(Apo E)ε3/ε4的基因型。海马体积用Slicer软件计算。采用独立样本 t 检验或 Mann-Whitney U 检验比较两组间各项指标的水平。斯皮尔曼相关分析用于分析各指标之间的相关性。绘制接收者操作特征曲线(ROC),计算曲线下面积(AUC),比较单独检测和联合检测血清载脂蛋白B100水平和海马体积对AD的诊断效果:结果:与健康对照组相比,AD组血清总胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白B100和血浆载脂蛋白E ε3/ε4水平较高,而AD组血清高密度脂蛋白(HDL)水平较低(均为P 结论:血清载脂蛋白B100水平对AD的诊断具有重要意义:AD患者血清载脂蛋白B100水平升高,海马体积缩小。两者联合检测对AD的诊断效率高于单独检测,有望成为未来诊断AD的重要指标。
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引用次数: 0
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