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Factors associated with disease knowledge and attitude among ambulatory patients with type 2 diabetes - a multicenter study. 与2型糖尿病流动患者的疾病知识和态度相关的因素--一项多中心研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-26 DOI: 10.1186/s12902-024-01696-0
Akinniyi A Aje, Titilayo O Fakeye

Background: Diabetes is a multifactorial disease state that requires adequate patient monitoring for improved health outcomes. Diabetes knowledge and attitude, and associated factors such as medication adherence, medication discrepancy, health literacy, and glycemic control were evaluated in this study. The selected factors were also compared with diabetes knowledge and attitude.

Methods: A cross-sectional study was carried out among ambulatory diabetes patients in three tertiary healthcare facilities in Nigeria. An interviewer-administered semi-structured questionnaire was utilized for data collection. Data was analysed using descriptive and inferential statistics with the level of significance set at p < 0.05.

Results: A total of 188 diabetes patients participated in the study; 51 (27.1%) at the Federal Medical Center, Abeokuta, 69 (36.7%) at the University College Hospital, Ibadan, and 68 (36.2%) at the University of Ilorin Teaching Hospital, Ilorin. One hundred and twelve (59.6%) female patients participated in the study and patients' average age was 58.69 ± 13.68 years. Medication discrepancy was observed among 101 (53.7%) patients. One hundred and three (54.8%), 47 (25.0%) and 38 (20.2%) had high, medium, and low medication adherence, respectively. Ninety-one (48.4%) had high health literacy. Mean diabetes knowledge score was 14.64 ± 2.55 points out of a maximum obtainable score of 18 points. Mean diabetes attitude of patients was 62.50 ± 6.86 points out of a maximum obtainable score of 70 points. Significant positive association was observed between diabetes knowledge and health literacy (Beta = 0.021, p = 0.029). Diabetes knowledge was higher in patients with higher level of formal education (p = 0.046), higher diabetes attitude (p < 0.001) and high health literacy (p = 0.002). Patients' diabetes attitude was higher in individuals older than 60 years of age (p = 0.029), and those with high health literacy (p = 0.005).

Conclusions: The diabetes patients displayed good disease knowledge, attitude and medication adherence. Average levels of health literacy and medication discrepancy was observed among the patients. Significant differences were observed between patients' diabetes knowledge and level of formal education, diabetes attitude, health literacy and age. Patients' health literacy was significantly associated with diabetes knowledge.

背景:糖尿病是一种多因素疾病,需要对患者进行充分监测以改善健康状况。本研究评估了糖尿病知识和态度以及相关因素,如用药依从性、用药差异、健康素养和血糖控制。所选因素还与糖尿病知识和态度进行了比较:在尼日利亚三家三级医疗机构的流动糖尿病患者中开展了一项横断面研究。在数据收集过程中使用了由访谈者发放的半结构化问卷。采用描述性和推论性统计方法对数据进行分析,显著性水平设定为 p 结果:共有 188 名糖尿病患者参与了研究,其中阿贝奥库塔联邦医疗中心 51 人(27.1%),伊巴丹大学学院医院 69 人(36.7%),伊洛林大学教学医院 68 人(36.2%)。112名(59.6%)女性患者参与了研究,患者的平均年龄为(58.69 ± 13.68)岁。在 101 名(53.7%)患者中观察到用药不一致现象。用药依从性分别为高、中和低的患者分别有 103 人(54.8%)、47 人(25.0%)和 38 人(20.2%)。91人(48.4%)具有较高的健康素养。糖尿病知识平均得分为 14.64±2.55 分,最高分为 18 分。患者对糖尿病的态度平均为(62.50±6.86)分,最高分为 70 分。糖尿病知识与健康素养之间呈显著正相关(Beta = 0.021,P = 0.029)。正规教育程度较高(p = 0.046)、糖尿病态度较端正(p 结论:糖尿病患者的糖尿病知识水平较高:糖尿病患者在疾病知识、态度和服药依从性方面表现良好。观察到患者的健康知识水平和用药差异处于平均水平。患者的糖尿病知识与正规教育水平、糖尿病态度、健康素养和年龄之间存在显著差异。患者的健康知识水平与糖尿病知识有明显相关性。
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引用次数: 0
Psychometrics properties of type 2 diabetes treatment adherence questionnaire (DTAQ): a study based on Pender's health promotion model. 2 型糖尿病治疗依从性问卷 (DTAQ) 的心理测量学特性:基于彭德健康促进模型的研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-26 DOI: 10.1186/s12902-024-01684-4
Nahid Shahabi, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad, Ahmad Behzad

Background: Management of type 2 diabetes (T2D) as a chronic disease requires treatment adherence such as controlling the blood glucose level and adopting a healthy lifestyle. The present study aimed to develop and psychometrically evaluate a questionnaire based on the Pender's Health Promotion Model (HPM) to measure treatment adherence and the associated factors among T2D patients.

Methods: The present study was conducted in qualitative and the quantitative phases between March 2022 and March 2023. The participants were T2D patients visiting Shahid Mohammadi hospital Diabetes Clinic in Bandar Abbas in the south of Iran. The first draft of items was extracted from the qualitative phase. The present study used interviews with T2D patients, item construction, validity and reliability evaluation of the instrument, and the relevant statistical analyses. It emphasized the significance of content, face, and construct validity, along with reliability testing using Cronbach's alpha and test-retest method. Data were analyzed using SPSS software, V16 and AMOS, V23.

Results: A 97-item questionnaire was developed through the qualitative phase and, after content validity, it was reduced to 86 items. Five items were removed in face validation, and after the test-retest method, 79 items were retained. The confirmatory factors analysis confirmed a 65-item model with appropriate fitness of data. Cronbach's alpha coefficient showed an acceptable reliability of the diabetes treatment adherence questionnaire (α = 0.92).

Conclusion: The questionnaire developed based on the HPM model provides a standard and comprehensive measurement of the degree of adherence to treatment and the associated factors among Iranian T2D patients. This is especially valuable in the Iranian healthcare context, where effective management of chronic diseases such as diabetes is of a top priority. Questionnaires can help identify barriers and facilitators of treatment adherence to inform systematic and goal-oriented interventions. The proposed questionnaire had good psychometric properties, and can be used as a valid and practical instrument to measure the factors related to treatment adherence behaviors.

背景:2 型糖尿病(T2D)是一种慢性疾病,需要坚持治疗,如控制血糖水平和采取健康的生活方式。本研究旨在根据彭德健康促进模型(HPM)编制调查问卷,并对其进行心理评估,以衡量 2 型糖尿病患者的治疗依从性及其相关因素:本研究于 2022 年 3 月至 2023 年 3 月期间分定性和定量两个阶段进行。参与者为在伊朗南部阿巴斯港沙希德-穆罕默迪医院糖尿病诊所就诊的 T2D 患者。项目初稿是从定性阶段中提取的。本研究采用了对 T2D 患者的访谈、项目构建、工具的有效性和可靠性评估以及相关的统计分析。研究强调了内容效度、表面效度和结构效度的重要性,并使用 Cronbach's alpha 和重测法进行了可靠性测试。数据使用 SPSS 软件 V16 和 AMOS 软件 V23 进行分析:通过定性阶段编制了 97 个项目的问卷,经过内容效度验证后,问卷减少到 86 个项目。在表面验证中删除了 5 个项目,经过重测法,保留了 79 个项目。确认性因素分析证实了 65 个项目的模型与数据的适当匹配性。Cronbach'sα系数显示糖尿病治疗依从性问卷的信度可以接受(α = 0.92):结论:基于 HPM 模型开发的问卷可对伊朗 T2D 患者的治疗依从性及其相关因素进行标准而全面的测量。在伊朗,有效管理糖尿病等慢性疾病是重中之重。问卷调查有助于确定坚持治疗的障碍和促进因素,为系统性和目标导向的干预措施提供依据。所建议的问卷具有良好的心理测量特性,可作为一种有效而实用的工具来测量与坚持治疗行为相关的因素。
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引用次数: 0
Prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus: a cross-sectional study in a tertiary care medical unit, Sri Lanka. 斯里兰卡一家三级医疗单位的一项横断面研究:2 型糖尿病患者贫血症的患病率和相关因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-23 DOI: 10.1186/s12902-024-01681-7
Sawandika Rupasinghe, Inoka Kumudini Jayasinghe

Background: Anaemia is a global public health issue that impacts individuals of all ages in both developed and developing countries. Anaemia is common in patients with diabetes mellitus; however, it is often undiagnosed and untreated. The main aim of this study was to assess the prevalence and associated factors of anaemia in patients with type 2 diabetes mellitus admitting to a medical unit at National Hospital Kandy.

Methods: A descriptive, cross-sectional study was conducted in type 2 diabetes mellitus (T2DM) patients admitted to a medical ward at National Hospital Kandy (NHK). They were assessed with a pre-tested, interviewer-administered, structured questionnaire using consecutive sampling method. The data was entered and analyzed using SPSS 26.

Results: Total 252 patients with diabetes were included. The prevalence of anaemia in patients with T2DM was 31.3%. The corresponding values for males and females were 34.2% and 65.8% respectively. Independent predictors for anaemia among diabetic patients were older age, female gender, poor glycemic control, diabetes duration > 5 years, diabetic nephropathy, retinopathy, neuropathy, stage ≥ 3 chronic kidney disease (CKD), ischaemic heart disease (IHD), peripheral vascular disease (PVD), diabetic foot ulcers (DFU) and usage of aspirin. These were significantly associated with the prevalence anemia among patients with type 2 diabetes mellitus. Multivariate logistic regression analysis revealed that female gender, age ≥ 65 years, diabetic duration > 5 years, poor glycaemic control, stage ≥ 3 CKD, diabetic nephropathy and retinopathy were associated with greater odds for the presence of anaemia.

Conclusion: We found that 31.3% T2DM patients in a medical ward at NHK had previously undiagnosed anaemia. Anaemia screening during diabetes diagnosis, maintaining glycaemic control and raising patient awareness can reduce anaemia prevalence, improve patient quality of life and potentially reduce microvascular complications.

背景:贫血是一个全球性的公共卫生问题,影响着发达国家和发展中国家各个年龄段的人。贫血在糖尿病患者中很常见,但往往得不到诊断和治疗。本研究的主要目的是评估康提国立医院医疗单位收治的 2 型糖尿病患者中贫血的患病率和相关因素:对康提国立医院(NHK)内科病房收治的2型糖尿病(T2DM)患者进行了一项描述性横断面研究。采用连续抽样的方法,对他们进行了预先测试、由访谈者主持的结构化问卷调查。数据使用 SPSS 26 进行输入和分析:共纳入 252 名糖尿病患者。T2DM 患者的贫血患病率为 31.3%。男性和女性的相应数值分别为 34.2% 和 65.8%。糖尿病患者贫血的独立预测因素包括:年龄较大、女性、血糖控制不佳、糖尿病病程大于 5 年、糖尿病肾病、视网膜病变、神经病变、慢性肾病 (CKD) ≥ 3 期、缺血性心脏病 (IHD)、外周血管疾病 (PVD)、糖尿病足溃疡 (DFU) 和服用阿司匹林。这些因素与 2 型糖尿病患者贫血的发生率有很大关系。多变量逻辑回归分析显示,女性性别、年龄≥65 岁、糖尿病病程大于 5 年、血糖控制不佳、慢性肾脏病≥3 期、糖尿病肾病和视网膜病变与贫血发生的几率较大相关:结论:我们发现,NHK 内科病房中 31.3% 的 T2DM 患者之前未确诊贫血。在糖尿病诊断过程中进行贫血筛查、保持血糖控制和提高患者意识可以降低贫血患病率、改善患者生活质量并减少微血管并发症。
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引用次数: 0
Predictive role of neutrophil-to-lymphocyte ratio in metabolic syndrome: Meta-analysis of 70,937 individuals. 中性粒细胞与淋巴细胞比率在代谢综合征中的预测作用:对 70,937 人进行的元分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-20 DOI: 10.1186/s12902-024-01689-z
Zhiqiang Qiu, Chahua Huang, Congcong Xu, Yan Xu

Objective: Neutrophil-to-lymphocyte ratio (NLR) has been shown to be an independent predictor for cardiovascular diseases and metabolic diseases. The role of NLR in metabolic syndrome (MS) has also been explored albeit with conflicting results. The objective of this study was to assess the predictive role of NLR in MS.

Methods: We conducted a meta-analysis of observational studies to evaluate the predictive role of NLR in MS. Cochrane library, PubMed, Medline, Embase, and Scopus were systematically searched from their inception to December 2023. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines was followed. The statistical analysis was performed using RevMan 5.3 software. A randomeffect model was used.

Results: Twenty six studies enrolling 70,937 individuals were included in this meta-analysis. Compared with the individuals without MS, NLR value was significantly higher in the patients of MS (mean difference (MD) 0.40, 95% confidence intervals (CI): 0.27-0.52, P < 0.00001, I2 = 97%). The derived NLR value also was significantly higher in participants with MS than those without MS (MD 0.48, 95%CI: 0.13-0.84, P = 0.007, I2 = 96%). There was no statistically significant association for NLR between the patients with 4 metabolic risk factors (MRF) and those with 3 MRF, or between patients with 5 MRF and those with 4 MRF (MD 0.16, 95%CI: -0.02-0.35, P = 0.10, I2 = 84%; MD 0.12, 95%CI: -0.06-0.29, P = 0.20, I2 = 68%). However, MS patients with 5 MRF had a significantly higher mean NLR value than those with 3MRF (MD 0.37, 95%CI: 0.05-0.68, P = 0.02, I2 = 92%). Compared with the individuals with low NLR, incidence of MS was significantly higher in those with high NLR (OR 2.23, 95%CI: 1.25-3.98, P = 0.006, I2 = 97%).

Conclusion: The findings of our meta-analysis suggested that the value of NLR and derived NLR were higher in MS patients. MS patients with 5 MRF had a significantly higher mean NLR value. High NLR also demonstrated a significantly increased the incidence of MS. NLR may be a good predictive biomarker in MS.

目的中性粒细胞与淋巴细胞比率(NLR)已被证明是心血管疾病和代谢性疾病的独立预测指标。也有人探讨了 NLR 在代谢综合征(MS)中的作用,但结果相互矛盾。本研究旨在评估 NLR 在 MS 中的预测作用:我们对观察性研究进行了荟萃分析,以评估 NLR 在 MS 中的预测作用。我们系统检索了 Cochrane 图书馆、PubMed、Medline、Embase 和 Scopus 中从开始到 2023 年 12 月的所有研究。研究遵循了系统综述和荟萃分析首选报告项目(PRISMA)指南。统计分析使用 RevMan 5.3 软件进行。结果:本次荟萃分析共纳入了 26 项研究,研究对象达 70,937 人。与非多发性硬化症患者相比,多发性硬化症患者的 NLR 值明显更高(平均差(MD)0.40,95% 置信区间(CI):0.27-0.52,P 2 = 97%)。多发性硬化症患者的 NLR 值也明显高于非多发性硬化症患者(MD 0.48,95% 置信区间:0.13-0.84,P = 0.007,I2 = 96%)。有4个代谢风险因素(MRF)的患者与有3个MRF的患者之间,或有5个MRF的患者与有4个MRF的患者之间,NLR均无统计学意义(MD 0.16,95%CI:-0.02-0.35,P = 0.10,I2 = 84%;MD 0.12,95%CI:-0.06-0.29,P = 0.20,I2 = 68%)。然而,有5个MRF的多发性硬化症患者的平均NLR值明显高于有3个MRF的患者(MD 0.37,95%CI:0.05-0.68,P = 0.02,I2 = 92%)。与 NLR 值低的人相比,NLR 值高的人多发性硬化症的发病率明显更高(OR 2.23,95%CI:1.25-3.98,P = 0.006,I2 = 97%):我们的荟萃分析结果表明,多发性硬化症患者的 NLR 和衍生 NLR 值较高。有 5 个 MRF 的多发性硬化症患者的平均 NLR 值明显更高。高 NLR 也表明多发性硬化症的发病率明显增加。NLR可能是预测多发性硬化症的良好生物标志物。
{"title":"Predictive role of neutrophil-to-lymphocyte ratio in metabolic syndrome: Meta-analysis of 70,937 individuals.","authors":"Zhiqiang Qiu, Chahua Huang, Congcong Xu, Yan Xu","doi":"10.1186/s12902-024-01689-z","DOIUrl":"10.1186/s12902-024-01689-z","url":null,"abstract":"<p><strong>Objective: </strong>Neutrophil-to-lymphocyte ratio (NLR) has been shown to be an independent predictor for cardiovascular diseases and metabolic diseases. The role of NLR in metabolic syndrome (MS) has also been explored albeit with conflicting results. The objective of this study was to assess the predictive role of NLR in MS.</p><p><strong>Methods: </strong>We conducted a meta-analysis of observational studies to evaluate the predictive role of NLR in MS. Cochrane library, PubMed, Medline, Embase, and Scopus were systematically searched from their inception to December 2023. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines was followed. The statistical analysis was performed using RevMan 5.3 software. A randomeffect model was used.</p><p><strong>Results: </strong>Twenty six studies enrolling 70,937 individuals were included in this meta-analysis. Compared with the individuals without MS, NLR value was significantly higher in the patients of MS (mean difference (MD) 0.40, 95% confidence intervals (CI): 0.27-0.52, P < 0.00001, I<sup>2</sup> = 97%). The derived NLR value also was significantly higher in participants with MS than those without MS (MD 0.48, 95%CI: 0.13-0.84, P = 0.007, I<sup>2</sup> = 96%). There was no statistically significant association for NLR between the patients with 4 metabolic risk factors (MRF) and those with 3 MRF, or between patients with 5 MRF and those with 4 MRF (MD 0.16, 95%CI: -0.02-0.35, P = 0.10, I<sup>2</sup> = 84%; MD 0.12, 95%CI: -0.06-0.29, P = 0.20, I<sup>2</sup> = 68%). However, MS patients with 5 MRF had a significantly higher mean NLR value than those with 3MRF (MD 0.37, 95%CI: 0.05-0.68, P = 0.02, I<sup>2</sup> = 92%). Compared with the individuals with low NLR, incidence of MS was significantly higher in those with high NLR (OR 2.23, 95%CI: 1.25-3.98, P = 0.006, I<sup>2</sup> = 97%).</p><p><strong>Conclusion: </strong>The findings of our meta-analysis suggested that the value of NLR and derived NLR were higher in MS patients. MS patients with 5 MRF had a significantly higher mean NLR value. High NLR also demonstrated a significantly increased the incidence of MS. NLR may be a good predictive biomarker in MS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study. 卡格列净和替尼列汀对日本 2 型糖尿病患者能量摄入和体重的影响比较:CANTABILE 研究的子分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-19 DOI: 10.1186/s12902-024-01690-6
Masahiro Isogawa, Hisashi Makino, Cheol Son, Kunihiro Nishimura, Takumi Hirata, Shu Kasama, Yoshihiro Miyamoto, Michio Noguchi, Masato Kasahara, Kiminori Hosoda

Background: While the Sodium-glucose co-transporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) are widely used for the glycemic control in type 2 diabetes mellitus, the differences in the effects of SGLT2 inhibitors and DPP4 inhibitors on energy intake and diabetes-related indicators are unclear.

Methods: This was a subanalysis of the CANTABILE study which compared the effects of canagliflozin and teneligliptin on metabolic factors in Japanese patients with Type 2 diabetes. The changes at 24 weeks from the baseline of the diabetes-related indicators including Hemoglobin A1c (HbA1c), energy intake and body weight were compared between the canagliflozin and teneligliptin groups.

Results: Seventy-five patients in the canagliflozin group and 70 patients in the teneligliptin group were analyzed. A significant decrease in HbA1c was observed in both groups. In the teneligliptin group, although energy intake was significantly reduced, there was no significant change in body weight. Conversely, in the canagliflozin group, although energy intake tended to increase, body weight significantly decreased.

Conclusion: Canagliflozin and teneligliptin have different effects on the dietary status of patients with Type 2 diabetes. Our result suggests that canagliflozin can manage blood glucose without weight gain, even with increased energy intake.

背景:虽然钠-葡萄糖协同转运体2(SGLT2)抑制剂和二肽基肽酶-4(DPP4)被广泛用于2型糖尿病的血糖控制,但SGLT2抑制剂和DPP4抑制剂对能量摄入和糖尿病相关指标的影响差异尚不清楚:本研究是CANTABILE研究的一项子分析,该研究比较了卡格列净和替尼列汀对日本2型糖尿病患者代谢因素的影响。结果比较了卡格列净组和替尼列汀组在24周时糖尿病相关指标(包括血红蛋白A1c (HbA1c)、能量摄入和体重)与基线相比的变化:对 75 名卡格列净组患者和 70 名替尼格列汀组患者进行了分析。两组患者的 HbA1c 均明显下降。在替格列汀组,虽然能量摄入明显减少,但体重却没有明显变化。相反,在卡格列净组,虽然能量摄入呈上升趋势,但体重却明显下降:结论:卡那格列净和替尼列汀对 2 型糖尿病患者的饮食状况有不同的影响。我们的研究结果表明,即使能量摄入增加,卡格列净也能控制血糖而不增加体重。
{"title":"Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study.","authors":"Masahiro Isogawa, Hisashi Makino, Cheol Son, Kunihiro Nishimura, Takumi Hirata, Shu Kasama, Yoshihiro Miyamoto, Michio Noguchi, Masato Kasahara, Kiminori Hosoda","doi":"10.1186/s12902-024-01690-6","DOIUrl":"10.1186/s12902-024-01690-6","url":null,"abstract":"<p><strong>Background: </strong>While the Sodium-glucose co-transporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) are widely used for the glycemic control in type 2 diabetes mellitus, the differences in the effects of SGLT2 inhibitors and DPP4 inhibitors on energy intake and diabetes-related indicators are unclear.</p><p><strong>Methods: </strong>This was a subanalysis of the CANTABILE study which compared the effects of canagliflozin and teneligliptin on metabolic factors in Japanese patients with Type 2 diabetes. The changes at 24 weeks from the baseline of the diabetes-related indicators including Hemoglobin A1c (HbA1c), energy intake and body weight were compared between the canagliflozin and teneligliptin groups.</p><p><strong>Results: </strong>Seventy-five patients in the canagliflozin group and 70 patients in the teneligliptin group were analyzed. A significant decrease in HbA1c was observed in both groups. In the teneligliptin group, although energy intake was significantly reduced, there was no significant change in body weight. Conversely, in the canagliflozin group, although energy intake tended to increase, body weight significantly decreased.</p><p><strong>Conclusion: </strong>Canagliflozin and teneligliptin have different effects on the dietary status of patients with Type 2 diabetes. Our result suggests that canagliflozin can manage blood glucose without weight gain, even with increased energy intake.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome. 利用胎盘间充质干细胞恢复多囊卵巢综合征大鼠模型的卵巢功能和代谢状况。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-19 DOI: 10.1186/s12902-024-01688-0
Mojtaba Sarvestani, Alireza Rajabzadeh, Tahereh Mazoochi, Mansooreh Samimi, Mohsen Navari, Faezeh Moradi

Introduction: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation.

Materials and methods: In this experimental study, twenty female Wistar rats were assigned to four groups (n = 5) including control, sham, PCOS, and PCOS+PDMSCs groups. Then, PCOS was induced in the rats through administering letrozole for 21 days. PDMSCs (1 × 106 cells) were injected through the tail vein. Fourteen days after the cell infusion, evaluation was performed on the number of healthy follicles, corpus luteum, and cystic follicles as well as the levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), fasting blood glucose, fasting insulin, and insulin resistance. Moreover, the serum levels of cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Liver function was also determined by the evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.

Results: The number of corpus luteum and primordial, primary, secondary, and antral follicles was significantly elevated in the PCOS+PDMSCs group compared to the PCOS group. However, the number of cystic follicles significantly decreased in the PCOS+PDMSCs group. The LH and testosterone levels also decreased significantly, while FSH levels increased significantly in the PCOS+PDMSCs group. The levels of fasting blood glucose, fasting insulin, and insulin resistance notably decreased in the PCOS+PDMSCs group. Moreover, the lipid profile improved in the PCOS+PDMSCs group along with a significant decrease of cholesterol, LDL, and TG and an increase in HDL. The PCOS+PDMSCs group exhibited marked decreases in the AST and ALT levels as well.

Conclusion: The results of this study suggest that PDMSCs are a potential treatment option for PCOS because they can effectively restore folliculogenesis and correct hormonal imbalances, lipid profiles and liver dysfunction in a rat model of PCOS. However, further research is needed to establish the safety and effectiveness of PDMSCs for treating PCOS.

导言多囊卵巢综合征(PCOS)是一种内分泌和代谢紊乱疾病,影响着全球许多妇女,其特征是慢性无排卵、高雄激素和卵巢功能障碍。胎盘间充质干细胞(PDMSCs)来源于胎盘,与其他来源的间充质干细胞相比,它在可用性、安全性和免疫调节方面具有优势:在这项实验研究中,20 只雌性 Wistar 大鼠被分为四组(n = 5),包括对照组、假阳性组、PCOS 组和 PCOS+PDMSCs 组。然后,通过给大鼠注射来曲唑诱导 PCOS,为期 21 天。通过尾静脉注射 PDMSCs(1 × 106 个细胞)。细胞注射 14 天后,对健康卵泡、黄体和囊性卵泡的数量以及睾酮、卵泡刺激素(FSH)、黄体生成素(LH)、空腹血糖、空腹胰岛素和胰岛素抵抗的水平进行评估。此外,还测量了血清中胆固醇、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的水平。此外,还通过评估天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)水平来确定肝功能:结果:与多囊卵巢综合征组相比,多囊卵巢综合征+PDMSCs组的黄体、原始卵泡、初级卵泡、次级卵泡和前卵泡数量明显增加。然而,PCOS+PDMSCs 组的囊性卵泡数量明显减少。PCOS+PDMSCs组的LH和睾酮水平也明显下降,而FSH水平则明显上升。PCOS+PDMSCs 组的空腹血糖、空腹胰岛素和胰岛素抵抗水平明显下降。此外,PCOS+PDMSCs 组的血脂状况也有所改善,胆固醇、低密度脂蛋白和总胆固醇显著下降,高密度脂蛋白增加。PCOS+PDMSCs 组的 AST 和 ALT 水平也明显下降:本研究的结果表明,PDMSCs 是治疗多囊卵巢综合征的一种潜在方法,因为它能有效恢复多囊卵巢综合征大鼠模型的卵泡生成,纠正激素失衡、血脂异常和肝功能异常。然而,还需要进一步的研究来确定 PDMSCs 治疗多囊卵巢综合症的安全性和有效性。
{"title":"Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome.","authors":"Mojtaba Sarvestani, Alireza Rajabzadeh, Tahereh Mazoochi, Mansooreh Samimi, Mohsen Navari, Faezeh Moradi","doi":"10.1186/s12902-024-01688-0","DOIUrl":"10.1186/s12902-024-01688-0","url":null,"abstract":"<p><strong>Introduction: </strong>Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation.</p><p><strong>Materials and methods: </strong>In this experimental study, twenty female Wistar rats were assigned to four groups (n = 5) including control, sham, PCOS, and PCOS+PDMSCs groups. Then, PCOS was induced in the rats through administering letrozole for 21 days. PDMSCs (1 × 10<sup>6</sup> cells) were injected through the tail vein. Fourteen days after the cell infusion, evaluation was performed on the number of healthy follicles, corpus luteum, and cystic follicles as well as the levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), fasting blood glucose, fasting insulin, and insulin resistance. Moreover, the serum levels of cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Liver function was also determined by the evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.</p><p><strong>Results: </strong>The number of corpus luteum and primordial, primary, secondary, and antral follicles was significantly elevated in the PCOS+PDMSCs group compared to the PCOS group. However, the number of cystic follicles significantly decreased in the PCOS+PDMSCs group. The LH and testosterone levels also decreased significantly, while FSH levels increased significantly in the PCOS+PDMSCs group. The levels of fasting blood glucose, fasting insulin, and insulin resistance notably decreased in the PCOS+PDMSCs group. Moreover, the lipid profile improved in the PCOS+PDMSCs group along with a significant decrease of cholesterol, LDL, and TG and an increase in HDL. The PCOS+PDMSCs group exhibited marked decreases in the AST and ALT levels as well.</p><p><strong>Conclusion: </strong>The results of this study suggest that PDMSCs are a potential treatment option for PCOS because they can effectively restore folliculogenesis and correct hormonal imbalances, lipid profiles and liver dysfunction in a rat model of PCOS. However, further research is needed to establish the safety and effectiveness of PDMSCs for treating PCOS.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study. 幽门螺杆菌感染与糖尿病并发症的关系:一项单中心回顾性研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-14 DOI: 10.1186/s12902-024-01678-2
Zhuoya Li, Jie Zhang, Yizhou Jiang, Kai Ma, Cheng Cui, Xiaoyong Wang

Background: Previous studies examined the association of Helicobacter pylori infection (H. pylori) with complications of diabetes, but the results have been inconsistent. The aim of this study of patients with type-2 diabetes (T2D) was to determine the association of H. pylori infection with the major complications of diabetes.

Methods: This single-center retrospective study examined patients with T2D who received H. pylori testing between January 2016 and December 2021. Logistic regression analyses were used to evaluate the association of H. pylori infection with four major complications of diabetes.

Results: We examined 960 patients with T2D, and 481 of them (50.1%) were positive for H. pylori. H. pylori infection was significantly associated with diabetic nephropathy (odds ratio [OR] = 1.462; 95% confidence interval [CI]: 1.006,2.126; P = 0.046). In addition, the co-occurrence of H. pylori positivity with hypertension (OR = 4.451; 95% CI: 2.351,8.427; P < 0.001), with glycated hemoglobin A1c (HbA1c) of at least 8% (OR = 2.925; 95% CI: 1.544,5.541; P = 0.001), and with diabetes duration of at least 9 years (OR = 3.305; 95% CI:1.823,5.993; P < 0.001) further increased the risk of diabetic nephropathy. There was no evidence of an association of H. pylori infection with retinopathy, neuropathy, or peripheral vascular disease.

Conclusions: Our study of T2D patients indicated that those with H. pylori infections had an increased risk of nephropathy, and this risk was greater in patients who also had hypertension, an HbA1c level of 8% or more, and diabetes duration of 9 years or more.

背景:以往的研究探讨了幽门螺杆菌感染与糖尿病并发症的关系,但结果并不一致。这项针对 2 型糖尿病(T2D)患者的研究旨在确定幽门螺杆菌感染与糖尿病主要并发症的关系:这项单中心回顾性研究调查了2016年1月至2021年12月期间接受幽门螺杆菌检测的T2D患者。采用逻辑回归分析评估幽门螺杆菌感染与糖尿病四种主要并发症的关系:我们对960名T2D患者进行了检查,其中481人(50.1%)幽门螺杆菌检测呈阳性。幽门螺杆菌感染与糖尿病肾病显著相关(几率比 [OR] = 1.462;95% 置信区间 [CI]:1.006,2.12%):1.006,2.126; P = 0.046).此外,幽门螺杆菌阳性与高血压同时存在(OR = 4.451;95% CI:2.351,8.427;P 结论:幽门螺杆菌阳性与高血压同时存在的可能性很高:我们对 T2D 患者的研究表明,幽门螺杆菌感染者发生肾病的风险增加,而同时患有高血压、HbA1c 水平达到或超过 8%、糖尿病病程达到或超过 9 年的患者发生肾病的风险更大。
{"title":"Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study.","authors":"Zhuoya Li, Jie Zhang, Yizhou Jiang, Kai Ma, Cheng Cui, Xiaoyong Wang","doi":"10.1186/s12902-024-01678-2","DOIUrl":"10.1186/s12902-024-01678-2","url":null,"abstract":"<p><strong>Background: </strong>Previous studies examined the association of Helicobacter pylori infection (H. pylori) with complications of diabetes, but the results have been inconsistent. The aim of this study of patients with type-2 diabetes (T2D) was to determine the association of H. pylori infection with the major complications of diabetes.</p><p><strong>Methods: </strong>This single-center retrospective study examined patients with T2D who received H. pylori testing between January 2016 and December 2021. Logistic regression analyses were used to evaluate the association of H. pylori infection with four major complications of diabetes.</p><p><strong>Results: </strong>We examined 960 patients with T2D, and 481 of them (50.1%) were positive for H. pylori. H. pylori infection was significantly associated with diabetic nephropathy (odds ratio [OR] = 1.462; 95% confidence interval [CI]: 1.006,2.126; P = 0.046). In addition, the co-occurrence of H. pylori positivity with hypertension (OR = 4.451; 95% CI: 2.351,8.427; P < 0.001), with glycated hemoglobin A1c (HbA1c) of at least 8% (OR = 2.925; 95% CI: 1.544,5.541; P = 0.001), and with diabetes duration of at least 9 years (OR = 3.305; 95% CI:1.823,5.993; P < 0.001) further increased the risk of diabetic nephropathy. There was no evidence of an association of H. pylori infection with retinopathy, neuropathy, or peripheral vascular disease.</p><p><strong>Conclusions: </strong>Our study of T2D patients indicated that those with H. pylori infections had an increased risk of nephropathy, and this risk was greater in patients who also had hypertension, an HbA1c level of 8% or more, and diabetes duration of 9 years or more.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The risk of thyroid cancer and sex differences in Hashimoto's thyroiditis, a meta-analysis. 桥本氏甲状腺炎患者罹患甲状腺癌的风险和性别差异的荟萃分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-13 DOI: 10.1186/s12902-024-01670-w
Yali Le, Chenchen Geng, Xiaoqian Gao, Ping Zhang

Background and objective: The prevalence of thyroid cancer (TC) has exhibited an upward trajectory in recent years. An accelerating amount of evidence shows a significant association between Hashimoto's thyroiditis (HT) and TC. The present study encompasses a meticulously designed systematic review and meta-analysis with the aim of scrutinizing the risk of TC and clarifying sex disparities in HT.

Methods: A comprehensive search was conducted across reputable online databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. English-language publications on the correlation between HT and TC were examined without temporal restrictions. Two authors independently screened the articles and extracted pertinent data. The collected data underwent statistical analysis using the STATA software, enabling the calculation of the pooled Odds Ratio (OR) and 95% confidence intervals (CI). Additionally, a supplementary analysis was conducted on studies incorporating sex-specific data to determine the OR (female vs. male) and the sex-based prevalence of TC in HT.

Results: A total of 2,845 records were obtained, and 26 retrospective studies were included in this meta-analysis. The results indicated a significant role for HT in TC (OR: 2.22, 95% CI: 1.85-2.67). Supplementary analysis indicated that the prevalence of TC in HT patients was lower in women (0.31, 95% CI: 0.17-0.45) than in men (0.37, 95% CI: 0.21-0.53). However, the result was not statistically significant.

Conclusion: This systematic review and meta-analysis provide evidence that HT is associated with increasing odds of TC. Regular review of HT patients holds positive clinical significance.

背景和目的:近年来,甲状腺癌(TC)的发病率呈上升趋势。越来越多的证据表明,桥本氏甲状腺炎(HT)与甲状腺癌之间存在显著关联。本研究包括一项精心设计的系统综述和荟萃分析,旨在仔细研究桥本氏甲状腺炎的风险,并澄清桥本氏甲状腺炎的性别差异:在PubMed、Cochrane Library、EMBASE和Web of Science等著名在线数据库中进行了全面检索。对有关 HT 和 TC 之间相关性的英文出版物进行了研究,没有时间限制。两位作者独立筛选文章并提取相关数据。使用 STATA 软件对收集到的数据进行统计分析,计算汇总的比值比 (OR) 和 95% 置信区间 (CI)。此外,还对包含性别特异性数据的研究进行了补充分析,以确定HT中TC的OR(女性与男性)和基于性别的患病率:本次荟萃分析共获得 2,845 条记录,纳入了 26 项回顾性研究。结果表明,HT 对 TC 有显著影响(OR:2.22,95% CI:1.85-2.67)。补充分析表明,女性高血压患者的血脂增高率(0.31,95% CI:0.17-0.45)低于男性(0.37,95% CI:0.21-0.53)。然而,这一结果在统计学上并不显著:本系统综述和荟萃分析提供了 HT 与 TC 发生几率增加有关的证据。对高血压患者进行定期复查具有积极的临床意义。
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引用次数: 0
Lipid profile alterations and biomarker identification in type 1 diabetes mellitus patients under glycemic control 血糖控制下 1 型糖尿病患者的血脂变化和生物标志物鉴定
IF 2.7 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.1186/s12902-024-01679-1
Yunying Cai, Xiaojie Qi, Yongqin Zheng, Jie Zhang, Heng Su
Type 1 diabetes mellitus (T1DM) is well-known to trigger a disruption of lipid metabolism. This study aimed to compare lipid profile changes in T1DM patients after achieving glucose control and explore the underlying mechanisms. In addition, we seek to identify novel lipid biomarkers associated with T1DM under conditions of glycemic control. A total of 27 adults with T1DM (age: 34.3 ± 11.2 yrs) who had maintained glucose control for over a year, and 24 healthy controls (age: 35.1 + 5.56 yrs) were recruited. Clinical characteristics of all participants were analyzed and plasma samples were collected for untargeted lipidomic analysis using mass spectrometry. We identified 594 lipid species from 13 major classes. Differential analysis of plasma lipid profiles revealed a general decline in lipid levels in T1DM patients with controlled glycemic levels, including a notable decrease in triglycerides (TAGs) and diglycerides (DAGs). Moreover, these T1DM patients exhibited lower levels of six phosphatidylcholines (PCs) and three phosphatidylethanolamines (PEs). Random forest analysis determined DAG(14:0/20:0) and PC(18:0/20:3) to be the most prominent plasma markers of T1DM under glycemic control (AUC = 0.966). The levels of all metabolites from the 13 lipid classes were changed in T1DM patients under glycemic control, with TAGs, DAGs, PCs, PEs, and FFAs demonstrating the most significant decrease. This research identified DAG(14:0/20:0) and PC(18:0/20:3) as effective plasma biomarkers in T1DM patients with controled glycemic levels.
众所周知,1 型糖尿病(T1DM)会引发脂质代谢紊乱。本研究旨在比较 T1DM 患者在血糖得到控制后的血脂变化,并探索其潜在机制。此外,我们还试图找出在血糖控制条件下与 T1DM 相关的新型血脂生物标志物。我们共招募了 27 名血糖控制超过一年的 T1DM 成人患者(年龄:34.3 ± 11.2 岁)和 24 名健康对照者(年龄:35.1 + 5.56 岁)。我们对所有参与者的临床特征进行了分析,并收集了血浆样本,利用质谱法进行非靶向脂质体分析。我们确定了 13 大类 594 种脂质。对血浆脂质谱的差异分析表明,在血糖水平得到控制的 T1DM 患者中,脂质水平普遍下降,其中甘油三酯 (TAG) 和甘油二酯 (DAG) 明显下降。此外,这些 T1DM 患者的六种磷脂酰胆碱 (PC) 和三种磷脂酰乙醇胺 (PE) 水平也较低。随机森林分析确定 DAG(14:0/20:0)和 PC(18:0/20:3)是血糖控制下 T1DM 最显著的血浆标记物(AUC = 0.966)。在血糖控制下,T1DM 患者 13 类脂质中所有代谢物的水平都发生了变化,其中 TAGs、DAGs、PCs、PEs 和 FFAs 的下降最为显著。这项研究发现,DAG(14:0/20:0)和 PC(18:0/20:3)是血糖得到控制的 T1DM 患者的有效血浆生物标志物。
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引用次数: 0
Generation of a mouse model of thyroid storm and preliminary investigation of the therapeutic effects of ghrelin 甲状腺风暴小鼠模型的建立和胃泌素治疗效果的初步研究
IF 2.7 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.1186/s12902-024-01680-8
Chiaki Kurimoto, Yasushi Furukawa, Takashi Akamizu, Asako Doi, Ken Takeshima, Shuhei Morita, Hiroshi Iwakura, Hiroyuki Ariyasu, Hiroto Furuta, Masahiro Nishi, Taka-Aki Matsuoka
Thyroid storm (TS), a life-threatening condition that can damage multiple organs, has limited therapeutic options. Hypercytokinemia is a suggested background, but the pathological condition is unclear and there are no appropriate animal models. We aimed to develop a TS mouse model by administration of triiodothyronine and lipopolysaccharide, and then to examine the effects of ghrelin on this model. We evaluated the use of serum IL-6 levels as a representative marker of hypercytokinemia in patients with TS. To establish the mouse model, preliminary experiments were conducted to determine the non-lethal doses of triiodothyronine and lipopolysaccharide when administered individually. As a TS model, C57BL/6 mice were administered with triiodothyronine 1.0 mg/kg (subcutaneously, once daily for seven consecutive days) and lipopolysaccharide 0.5 mg/kg (intraperitoneally, on day 7) to develop a lethal model with approximately 30% survival on day 8. We assessed the survival ratio, mouse sepsis scores and blood biomarkers (IL-6, metanephrine, alanine aminotransferase) and evaluated the effects of ghrelin 300 µg/kg on these parameters in TS model. Serum IL-6 was increased in patients with TS compared with those with Graves’ disease as the diseased control (18.2 vs. 2.85 pg/mL, P < .05, n = 4 each). The dosage for the murine TS model was triiodothyronine 1.0 mg/kg and lipopolysaccharide 0.5 mg/kg. The TS model group had increased mouse sepsis score, serum IL-6, metanephrine and alanine aminotransferase. In this model, the ghrelin improved the survival rate to 66.7% (P < .01, vs. 0% [saline-treated group]) as well as the mouse sepsis score, and it decreased the serum IL-6 and metanephrine. We established an animal model of TS that exhibits pathophysiological states similar to human TS with induction of serum IL-6 and other biomarkers by administration of T3 and LPS. The results suggest the potential effectiveness of ghrelin for TS in humans.
甲状腺风暴(TS)是一种危及生命的疾病,可损害多个器官,但治疗方法却很有限。高细胞血红蛋白血症被认为是一种背景疾病,但其病理条件尚不清楚,也没有合适的动物模型。我们的目标是通过服用三碘甲状腺原氨酸和脂多糖来建立 TS 小鼠模型,然后研究胃泌素对该模型的影响。我们评估了使用血清 IL-6 水平作为 TS 患者高细胞血红蛋白血症的代表性标记物。为了建立小鼠模型,我们进行了初步实验,以确定单独施用三碘甲状腺原氨酸和脂多糖时的非致死剂量。作为一种 TS 模型,我们给 C57BL/6 小鼠注射了三碘甲状腺原氨酸 1.0 毫克/千克(皮下注射,每天一次,连续七天)和脂多糖 0.5 毫克/千克(腹腔注射,第 7 天),从而建立了一种第 8 天存活率约为 30% 的致死模型。我们评估了存活率、小鼠败血症评分和血液生物标志物(IL-6、肾上腺素、丙氨酸氨基转移酶),并评估了胃泌素 300 µg/kg 对 TS 模型中这些参数的影响。与作为疾病对照的巴塞杜氏病患者相比,TS患者的血清IL-6升高(18.2 pg/mL vs. 2.85 pg/mL,P < .05,n = 4)。小鼠 TS 模型的剂量为三碘甲状腺原氨酸 1.0 毫克/千克和脂多糖 0.5 毫克/千克。TS 模型组的小鼠败血症评分、血清 IL-6、肾上腺素和丙氨酸氨基转移酶均有所升高。在该模型中,胃泌素可将存活率提高至 66.7%(P < .01,与 0% [生理盐水处理组]相比),并提高小鼠败血症评分,降低血清 IL-6 和肾上腺素。我们建立的 TS 动物模型表现出与人类 TS 相似的病理生理状态,通过给予 T3 和 LPS 诱导血清 IL-6 和其他生物标志物。结果表明,胃泌素对人类 TS 有潜在的疗效。
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引用次数: 0
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BMC Endocrine Disorders
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