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Cholesterol to saturated fat index (CSI), metabolic parameters and inflammatory factors among obese individuals. 肥胖者的胆固醇饱和脂肪指数(CSI)、代谢参数和炎症因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-02 DOI: 10.1186/s12902-024-01697-z
Mehrnaz Shakarami, Burhan Abdullah Zaman, Abdullah Sedaghat, Huda Muhammad Abbas Qassem, Yamamah Abas Zedann, Nashat Ali Soud, Mohaned Adil, Shabnam Shirvani, Naghmeh Nikbin

Background: The role of dietary fat quality in promotion of cardiovascular diseases is studies before. However, the results are inconsistent. Recently, cholesterol to saturated fatty acid index (CSI) is suggested as a novel indicator of the atherogenicity and thrombogenicity potential of a diet. However, due to limited number of studies, in the current cross-sectional study, we aimed to evaluate the role of CSI in metabolic and inflammatory response among obese individuals.

Methods: In the current cross-sectional study 488 obese individuals aged 18-50 years old were involved in volunteer based invitation from outpatient obesity clinics. Subjects underwent anthropometric assays including weight, height, waist circumference (WC) and body composition and their fasting blood sample were obtained for biochemical assessments including blood sugar, serum lipids, hs-CRP and IL-6 concentrations by commercial kits. Physical activity was also assessed by short form of international physical activity questionnaire (IPAQ).

Results: According to our results, being at the top tetile of CSI was associated with higher anthropometric indices including weight, height, WC, FFM, and basal metabolic rate (BMR) compared with those at the lowest tertile (P < 0.05). Similarly, those at the highest category of CSI had significantly higher levels of serum glucose and hs-CRP both in crude and adjusted models in ANCOVA and in multinomial logistic regression models (P < 0.05).

Conclusion: In the current study, for the first time, we identified the possible triggering role of dietary cholesterol to saturated fat index in increasing serum glucose and hs-CRP levels. due to cross-sectional design of the current study, causal inference is impossible. Further studies will help for better scientific justification.

背景:关于膳食脂肪质量在促进心血管疾病中的作用的研究以前就有。然而,研究结果并不一致。最近,胆固醇-饱和脂肪酸指数(CSI)被认为是衡量膳食致动脉粥样硬化性和血栓形成可能性的新指标。然而,由于研究数量有限,在本次横断面研究中,我们旨在评估 CSI 在肥胖者代谢和炎症反应中的作用:在本次横断面研究中,我们邀请了 488 名年龄在 18-50 岁之间的肥胖者作为志愿者,他们来自肥胖症门诊。受试者接受了人体测量测定,包括体重、身高、腰围(WC)和身体成分,并通过商用试剂盒采集空腹血样进行生化评估,包括血糖、血脂、hs-CRP 和 IL-6 浓度。此外,还通过国际体力活动调查问卷(IPAQ)简表对体力活动进行了评估:结果:根据我们的研究结果,与最低三分位数的人相比,处于 CSI 最高四分位数的人与较高的人体测量指数相关,包括体重、身高、腹围、FFM 和基础代谢率(BMR)(P 结论:CSI 最高四分位数的人与较高的人体测量指数相关,包括体重、身高、腹围、FFM 和基础代谢率(BMR):在本研究中,我们首次发现了膳食胆固醇-饱和脂肪指数在增加血清葡萄糖和 hs-CRP 水平中可能起到的诱发作用。进一步的研究将有助于更好地进行科学论证。
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引用次数: 0
Correlation of serum thyrotropin and thyroid hormone levels with diabetic kidney disease: a cross-sectional study. 血清甲状腺素和甲状腺激素水平与糖尿病肾病的相关性:一项横断面研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-30 DOI: 10.1186/s12902-024-01699-x
Jie Gao, Jingfang Liu

Objective: The relationship between thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and diabetic kidney disease (DKD) is still controversial, and this study analyzed the correlation between TSH, FT3, FT4 and DKD in patients with type 2 diabetes mellitus (T2DM).

Methods: T2DM patients (1216) were divided into five groups based on serum TSH, FT3, and FT4 levels, differences in urinary albumin excretion rate (UACR), estimated glomerular filtration rate (eGFR) were compared. Binary logistic regression verified independent correlations among TSH, FT3, FT4 and UACR, eGFR. TSH and FT3 predictive values for DKD were analyzed using receiver operating characteristic (ROC) curves.

Results: The prevalence of albuminuria with decreased eGFR was higher in T2DM patients with subclinical hypothyroidism and overt hypothyroidism than that in patients with normal thyroid function. TSH positively correlated with UACR (r = 0.133, p < 0.001) and positively correlated with eGFR (r = -0.218, p < 0.001), FT3 negatively correlated with UACR (r = -0.260, p < 0.001) and positively correlated with eGFR (r = 0.324, p < 0.001). With the change from the lower normal level to the increased level of TSH and the change from the higher normal level to the reduced level of FT3, the prevalence of albuminuria gradually increased, the prevalence of decreased eGFR gradually increased in TSH groups and FT3 groups. After adjusting for age, BMI, duration of diabetes, TPOAb, TGAb, smoking, drinking, hypertension, the use of anti-diabetic medications (metformin, sodium-glucose cotransporter 2 inhibitors), HbA1c, CRP, TC, TG, LDL-C, and HDL-C, both TSH and FT3 correlated with increased UACR (TSH: OR 1.253, p = 0.001; FT3: OR 0.166, p < 0.001) and decreased eGFR (TSH: OR 1.245, p < 0.001, FT3: OR 0.579, p < 0.001), but this correlation of TSH with eGFR < 60 mL/min/1.73 m2 was not found in male. The area under the ROC curve (AUC) for FT3 was greater than that for TSH (FT3: 0.64; TSH: 0.61).

Conclusions: Increased TSH and reduced FT3 levels were associated with DKD in T2DM patients, but in a sex-dependent manner. FT3 had a higher predictive value for DKD.

目的本研究分析了2型糖尿病(T2DM)患者促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)与糖尿病肾病(DKD)之间的相关性:根据血清促甲状腺激素(TSH)、胰高血糖素(FT3)和胰高血糖素(FT4)水平将1216名2型糖尿病患者分为5组,比较尿白蛋白排泄率(UACR)和估计肾小球滤过率(eGFR)的差异。二元逻辑回归验证了 TSH、FT3、FT4 与 UACR 和 eGFR 之间的独立相关性。使用接收器操作特征曲线(ROC)分析了 TSH 和 FT3 对 DKD 的预测值:结果:与甲状腺功能正常的患者相比,亚临床甲状腺功能减退症和显性甲状腺功能减退症的T2DM患者出现白蛋白尿和eGFR下降的比例更高。男性患者的 TSH 与 UACR 呈正相关(r = 0.133,p 2)。FT3的ROC曲线下面积(AUC)大于TSH(FT3:0.64;TSH:0.61):结论:TSH升高和FT3降低与T2DM患者的DKD有关,但与性别有关。FT3对DKD具有较高的预测价值。
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引用次数: 0
Risk factors for neonatal hypoglycemia: a meta-analysis. 新生儿低血糖症的风险因素:一项荟萃分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-30 DOI: 10.1186/s12902-024-01700-7
Dandan Wang, Xuchen Zhou, Juan Ning, Fen He, Junhui Shi, Xuefeng Jin

Objective: This Study aims to investigate the risk factors of hypoglycemia in neonates through meta-analysis.

Method: PubMed, Embase, Cochrane library, and Web of science databases were searched for case-control studies on risk factors for neonatal hypoglycemia. The search was done up to 1st October 2023 and Stata 15.0 was used for data analysis.

Results: A total of 12 published studies were included, including 991 neonates in the hypoglycemic group and 4388 neonates in the non-hypoglycemic group. Meta-analysis results suggested caesarean section [OR = 1.90 95%CI (1.23, 2.92)], small gestational age[OR = 2.88, 95%CI (1.59, 5.20)], gestational diabetes [OR = 1.65, 95%CI (1.11, 2.46)], gestational hypertension[OR = 2,79, 95%CI (1.78, 4.35)] and respiratory distress syndrome[OR = 5.33, 95%CI (2.22, 12.84)] were risk factors for neonatal hypoglycemia.

Conclusion: Based on the current study, we found that caesarean section, small gestational age, gestational diabetes, gestational hypertension, respiratory distress syndrome are risk factors for neonatal hypoglycemia.

Prospero registration number: CRD42023472974.

研究目的本研究旨在通过荟萃分析探讨新生儿低血糖症的风险因素:方法:在 PubMed、Embase、Cochrane library 和 Web of science 数据库中检索有关新生儿低血糖风险因素的病例对照研究。搜索时间截至 2023 年 10 月 1 日,数据分析使用 Stata 15.0:共纳入了 12 项已发表的研究,其中低血糖组有 991 名新生儿,非低血糖组有 4388 名新生儿。元分析结果显示,剖腹产[OR = 1.90 95%CI (1.23, 2.92)]、小胎龄[OR = 2.88, 95%CI (1.59, 5.20)]、妊娠糖尿病[OR = 1.65, 95%CI (1.11,2.46)]、妊娠高血压[OR = 2.79,95%CI(1.78,4.35)]和呼吸窘迫综合征[OR = 5.33,95%CI(2.22,12.84)]是新生儿低血糖的危险因素:基于本次研究,我们发现剖腹产、小胎龄、妊娠糖尿病、妊娠高血压、呼吸窘迫综合征是新生儿低血糖的危险因素:CRD42023472974。
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引用次数: 0
Association between Helicobacter pylori infection and type 2 diabetes mellitus: a retrospective cohort study and bioinformatics analysis. 幽门螺杆菌感染与 2 型糖尿病之间的关系:一项回顾性队列研究和生物信息学分析。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-30 DOI: 10.1186/s12902-024-01694-2
Jiaqi Li, Wenjie Yuan, Jing Liu, Bowei Yang, Xiao Xu, Xiaoxia Ren, Lianxu Jia

Purpose: This study aimed to preliminarily investigate the association and possible mechanisms between Helicobacter. pylori (H. pylori) infection and type 2 diabetes mellitus (T2DM) through data collection, statistical analysis, and bioinformatics analysis.

Methods: A retrospective cohort study, including a total of 4406 participants who attended annual health checkups at Xian GEM Flower Changqing Hospital, was conducted to explore the correlation between the incidence of T2DM and H. pylori infection. To uncover the potential mechanisms underlying the interaction between the two diseases, differentially expressed genes (DEGs) common to T2DM and H. pylori infection were identified using the GEO database and Venn diagrams. These DEGs were then analyzed through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) analysis.

Results: In total, 2053 participants were classified into the H. pylori-positive group and 2353 into the H. pylori-negative group. H. pylori infection was associated with a higher risk of T2DM occurrence (adjusted HR 1.59; 95% CI 1.17-2.15, P = 0.003). The average disease-free survival time was 34.81 months (95% CI 34.60-35.03 months) in the H. pylori positive group and 35.42 months (95% CI 35.28-35.56 months) in the H. pylori negative group. Multivariate analysis and subgroup analyses also showed that H. pylori infection increased the risk of developing T2DM. A total of 21 DEGs between T2DM and H. pylori infection were identified and enriched in 7 signaling pathways, indicating specific protein interactions.

Conclusions: The prevalence of T2DM was associated with H. pylori infection. T2DM and H. pylori infection may interact with each other through metabolic and immune pathways.

目的:本研究旨在通过数据收集、统计分析和生物信息学分析,初步探讨幽门螺杆菌(H. pylori)感染与2型糖尿病(T2DM)之间的相关性及其可能的机制:方法:通过一项回顾性队列研究,包括4406名在西安创业板花长青医院参加年度健康体检的参与者,探讨T2DM发病率与幽门螺杆菌感染之间的相关性。为了揭示这两种疾病之间相互作用的潜在机制,研究人员利用 GEO 数据库和维恩图确定了 T2DM 和幽门螺杆菌感染共同的差异表达基因(DEGs)。然后通过基因本体(GO)、京都基因和基因组百科全书(KEGG)富集和蛋白质相互作用(PPI)分析对这些 DEGs 进行了分析:结果:共有 2053 人被归入幽门螺杆菌阳性组,2353 人被归入幽门螺杆菌阴性组。幽门螺杆菌感染与较高的 T2DM 发生风险相关(调整后 HR 1.59;95% CI 1.17-2.15,P = 0.003)。幽门螺杆菌阳性组的平均无病生存期为 34.81 个月(95% CI 34.60-35.03 个月),幽门螺杆菌阴性组为 35.42 个月(95% CI 35.28-35.56 个月)。多变量分析和亚组分析还显示,幽门螺杆菌感染会增加罹患 T2DM 的风险。在T2DM和幽门螺杆菌感染之间共发现了21个DEGs,并在7个信号通路中富集,表明存在特定的蛋白质相互作用:结论:T2DM的发病率与幽门螺杆菌感染有关。结论:T2DM的发病率与幽门螺杆菌感染有关,T2DM和幽门螺杆菌感染可能通过代谢和免疫途径相互作用。
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引用次数: 0
Time to first optimal glycemic control and its predictors among adult type 2 diabetes patients in Amhara Regional State comprehensive specialized hospitals, Northwest Ethiopia. 埃塞俄比亚西北部阿姆哈拉地区州综合专科医院成年 2 型糖尿病患者首次达到最佳血糖控制的时间及其预测因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-30 DOI: 10.1186/s12902-024-01695-1
Sintayehu Chalie, Atsede Alle Ewunetie, Moges Agazhe Assemie, Atalay Liknaw, Friehiwot Molla, Animut Takele Telayneh, Bekalu Endalew

Background: Inadequate glycemic management in type 2 diabetes Mellitus patients is a serious public health issue and a key risk factor for progression as well as diabetes-related complications. The main therapeutic goal of preventing organ damage and other problems caused by diabetes is glycemic control. Knowing when to modify glycemic control in type 2 diabetes Mellitus is crucial for avoiding complications and early drug intensifications.

Methods: An institutional based retrospective follow-up study was undertaken among 514 eligible adult diabetes patients in Amhara region Comprehensive Specialized Hospitals, Northwest Ethiopia, from January 2017 to January 2022. Simple random sampling technique was used to select study participants. The Kaplan Meier curve was used to assess the survival status of categorical variables, and the log-rank test was used to compare them. The cox proportional hazard model was fitted to identify the predictors of time to first optimal glycemic control. Variables with a p-value < 0.05 were considered to be statistically significance at 95% confidence interval.

Results: A total of 514 patient records (227 males and 287 females) were reviewed in this study. The median time to first optimal glycemic control among the study population was 8.4 months IQR (7.6-9.7). The predictors that affect the time to first optimal glycemic control were age group ((AHR = 0.63, 95% CI = 0.463, 0.859 for 50-59 years), (AHR = 0.638, 95% CI = 0.471, 0.865 for 60-69 years), and (AHR = 0.480, 95% CI = 0.298, 0.774 for > = 70 years)), diabetes neuropathy (AHR = 0.629, 95% CI = 0.441,0.900), hypertension (AHR = 0.667, 95% CI = 0.524, 0.848), dyslipidemia (AHR = 0.561, 95% CI = 0.410, 0.768), and cardiovascular disease (AHR = 0.681, 95% CI = 0.494, 0.938).

Conclusion: The median time to initial optimal glycemic control in type 2 diabetes Mellitus patients in this study was short. Age between 50 and 59 years and 60-69, diabetes neuropathy, hypertension, dyslipidemia, and cardiovascular disease were predictor's of time to first glycemic control. Therefore, health care providers should pay extra attention for patients who are aged and who have complications or co-morbidities.

背景:2 型糖尿病患者血糖管理不足是一个严重的公共卫生问题,也是导致病情恶化和糖尿病相关并发症的关键风险因素。预防糖尿病引起的器官损伤和其他问题的主要治疗目标是控制血糖。了解何时调整 2 型糖尿病患者的血糖控制对避免并发症和早期药物强化至关重要:2017年1月至2022年1月,在埃塞俄比亚西北部阿姆哈拉地区综合专科医院对514名符合条件的成年糖尿病患者进行了一项基于机构的回顾性随访研究。研究采用简单随机抽样技术选取参与者。采用卡普兰-梅尔曲线评估分类变量的生存状况,并用对数秩检验进行比较。为确定首次最佳血糖控制时间的预测因素,采用了 cox 比例危险模型。变量的 p 值 结果:本研究共审查了 514 份病历(男性 227 份,女性 287 份)。研究人群中首次血糖控制达标的中位时间为 8.4 个月 IQR(7.6-9.7)。影响首次最佳血糖控制时间的预测因素是年龄组(50-59 岁为 0.63,95% CI = 0.463,0.859),60-69 岁为 0.638,95% CI = 0.471,0.865),>=70 岁为 0.480,95% CI = 0.298,0.774)。774 for > = 70 years))、糖尿病神经病变(AHR = 0.629,95% CI = 0.441,0.900)、高血压(AHR = 0.667,95% CI = 0.524,0.848)、血脂异常(AHR = 0.561,95% CI = 0.410,0.768)和心血管疾病(AHR = 0.681,95% CI = 0.494,0.938):本研究中,2 型糖尿病患者达到初始最佳血糖控制的中位时间较短。年龄在 50 至 59 岁和 60 至 69 岁之间、糖尿病神经病变、高血压、血脂异常和心血管疾病是血糖首次控制时间的预测因素。因此,医护人员应格外关注高龄、有并发症或合并症的患者。
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引用次数: 0
Use of a decision support tool and quick start onboarding tool in individuals with type 1 diabetes using advanced automated insulin delivery: a single-arm multi-phase intervention study. 在使用高级自动胰岛素给药的 1 型糖尿病患者中使用决策支持工具和快速入门工具:单臂多阶段干预研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-30 DOI: 10.1186/s12902-024-01709-y
Shekhar Sehgal, Martin De Bock, Benyamin Grosman, Jonathan Williman, Natalie Kurtz, Vanessa Guzman, Andrea Benedetti, Anirban Roy, Kamuran Turksoy, Magaly Juarez, Shirley Jones, Carla Frewen, Antony Watson, Barry Taylor, Benjamin J Wheeler

Background: Multiple clinician adjustable parameters impact upon glycemia in people with type 1 diabetes (T1D) using Medtronic Mini Med 780G (MM780G) AHCL. These include glucose targets, carbohydrate ratios (CR), and active insulin time (AIT). Algorithm-based decision support advising upon potential settings adjustments may enhance clinical decision-making.

Methods: Single-arm, two-phase exploratory study developing decision support to commence and sustain AHCL. Participants commenced investigational MM780G, then 8 weeks Phase 1-initial optimization tool evaluation, involving algorithm-based decision support with weekly AIT and CR recommendations. Clinicians approved or rejected CR and AIT recommendations based on perceived safety per protocol. Co-design resulted in a refined algorithm evaluated in a further identically configured Phase 2. Phase 2 participants also transitioned to commercial MM780G following "Quick Start" (algorithm-derived tool determining initial AHCL settings using daily insulin dose and weight). We assessed efficacy, safety, and acceptability of decision support using glycemic metrics, and the proportion of accepted CR and AIT settings per phase.

Results: Fifty three participants commenced Phase 1 (mean age 24.4; Hba1c 61.5mmol/7.7%). The proportion of CR and AIT accepted by clinicians increased between Phases 1 and 2 respectively: CR 89.2% vs. 98.6%, p < 0.01; AIT 95.2% vs. 99.3%, p < 0.01. Between Phases, mean glucose percentage time < 3.9mmol (< 70mg/dl) reduced (2.1% vs. 1.4%, p = 0.04); change in mean TIR 3.9-10mmol/L (70-180mg/dl) was not statistically significant: 72.9% ± 7.8 and 73.5% ± 8.6. Quick start resulted in stable TIR, and glycemic metrics compared to international guidelines.

Conclusion: The co-designed decision support tools were able to deliver safe and effective therapy. They can potentially reduce the burden of diabetes management related decision making for both health care practitioners and patients.

Trial registration: Prospectively registered with Australia/New Zealand Clinical Trials Registry(ANZCTR) on 30th March 2021 as study ACTRN12621000360819.

背景:使用美敦力 Mini Med 780G (MM780G) AHCL 的 1 型糖尿病 (T1D) 患者的血糖会受到多个临床医生可调参数的影响。这些参数包括血糖目标值、碳水化合物比率 (CR) 和胰岛素作用时间 (AIT)。基于算法的决策支持可为潜在的设置调整提供建议,从而提高临床决策水平:单臂、两阶段探索性研究,为开始和维持 AHCL 开发决策支持。参与者开始接受研究性 MM780G,然后进行为期 8 周的第一阶段-初始优化工具评估,包括基于算法的决策支持,以及每周的 AIT 和 CR 建议。临床医生根据治疗方案的安全性,批准或拒绝 CR 和 AIT 建议。共同设计的结果是在配置完全相同的第 2 阶段对改进后的算法进行评估。第二阶段的参与者也在 "快速启动 "后过渡到商用 MM780G(算法衍生工具使用每日胰岛素剂量和体重确定初始 AHCL 设置)。我们使用血糖指标评估了决策支持的有效性、安全性和可接受性,以及每个阶段接受 CR 和 AIT 设置的比例:53 名参与者开始了第一阶段(平均年龄 24.4 岁;Hba1c 61.5mmol/7.7%)。临床医生接受 CR 和 AIT 的比例在第一阶段和第二阶段之间分别有所增加:CR 89.2% vs. 98.6%, p 结论:共同设计的决策支持工具能够提供安全有效的治疗。它们有可能减轻医护人员和患者在糖尿病管理决策方面的负担:该试验于 2021 年 3 月 30 日在澳大利亚/新西兰临床试验注册中心(ANZCTR)进行了前瞻性注册,注册名为 ACTRN12621000360819。
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引用次数: 0
Blood glucose control among type 2 diabetic farmers in Chinese resettlement areas: a mixed methods study. 中国移民安置区 2 型糖尿病农民的血糖控制:一项混合方法研究。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-29 DOI: 10.1186/s12902-024-01686-2
Yubing Lu, Caixia Li, Wei Xu, Shukai Lv, Leilei Li

Background: Due to China's rapid urbanization, many farmers have relocated to urban resettlement regions. There is limited research on the glycemic control of Type 2 diabetes mellitus (T2DM) farmers in these areas. This study examined their blood glucose control and its determinants.

Methods: This study took place from March 2021 to January 2022 in a resettlement community in Yiwu, Zhejiang Province, China. In the first phase, a quantitative survey of 181 T2DM farmers was conducted using a questionnaire to gather demographic data, blood glucose control status, disease cognition levels, and treatment compliance. Inclusion criteria were migrant workers with ≥ 3 months of residence and local household registration and T2DM patients who met the diagnostic criteria of the Chinese guidelines. In the second phase, qualitative research involved face-to-face, semi-structured interviews with 15 patients with varying blood glucose control levels to analyze their experiences.

Results: The blood glucose control rate in this particular group was 27.62%, and the average disease cognition score was 2.5 ± 0.75. Many patients (67.96%) had inadequate treatment compliance, specifically in monitoring compliance (4.45 ± 1.92) and regular review compliance (3.58 ± 1.74).

Conclusion: There is a need for tailored programs to improve glycemic control among resettled farmers. Enhancing disease awareness and treatment compliance through targeted education and support is crucial. Further studies are needed to evaluate different treatment regimens' impact on glycemic control.

Clinical trial number: Not applicable.

背景:随着中国城市化进程的加快,许多农民搬迁到城市安置区。有关这些地区 2 型糖尿病(T2DM)农民血糖控制情况的研究十分有限。本研究探讨了他们的血糖控制情况及其决定因素:本研究于 2021 年 3 月至 2022 年 1 月在中国浙江省义乌市的一个安置社区进行。第一阶段,通过问卷对 181 名 T2DM 农民进行定量调查,收集人口统计学数据、血糖控制状况、疾病认知水平和治疗依从性。纳入标准为居住时间≥3个月且具有当地户籍的农民工,以及符合中国指南诊断标准的T2DM患者。第二阶段是定性研究,对15名血糖控制水平不同的患者进行面对面、半结构化访谈,分析他们的经历:结果:该组患者的血糖控制率为 27.62%,疾病认知平均得分为 2.5 ± 0.75。许多患者(67.96%)的治疗依从性不足,特别是监测依从性(4.45 ± 1.92)和定期复查依从性(3.58 ± 1.74):结论:有必要制定有针对性的计划,以改善重新安置农民的血糖控制。通过有针对性的教育和支持提高对疾病的认识和治疗依从性至关重要。需要进一步开展研究,评估不同治疗方案对血糖控制的影响:临床试验编号:不适用。
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引用次数: 0
mTOR gene variant rs2295080 might be a risk factor for atherosclerosis in Iranian women with type 2 diabetes mellitus. mTOR基因变异体rs2295080可能是伊朗女性2型糖尿病患者动脉粥样硬化的风险因素。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-29 DOI: 10.1186/s12902-024-01703-4
Afsaneh Zare, Shahdad Khosropanah, Gholamreza Daryabor, Mehrnoosh Doroudchi

Background: Type 2 diabetes mellitus, one of the most prevalent metabolic disorders worldwide, is closely linked with an enhanced risk of atherosclerosis. However, the molecular mechanism of this linkage is not still clear. Genetic variations in the mTOR gene may increase the susceptibility of individuals to these diseases.

Methods: One hundred nine diabetic patients and 375 healthy subjects participated in this study. mTOR Single Nucleotide Polymorphism (SNP) rs2295080 was determined using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).

Results: Comparison of genotypic, allelic, and genotypic combination frequencies between cases and controls revealed no significant result. Nevertheless, the frequency of rs2295080 GT + TT genotype was significantly more in diabetic women with atherosclerosis compared with those without atherosclerosis (p = 0.047). Besides, the rs2295080 G allele was more frequently detected in diabetic women without atherosclerosis compared to those with atherosclerosis (p = 0.046).

Conclusion: The rs2295080 GT + TT genotype predisposes Iranian diabetic women to atherosclerosis, while the rs2295080 G allele protects them against atherosclerosis. However, additional experiments using larger sample sizes are needed to verify this result.

背景:2 型糖尿病是全球最常见的代谢性疾病之一,与动脉粥样硬化风险的增加密切相关。然而,这种联系的分子机制尚不清楚。mTOR基因的遗传变异可能会增加个体对这些疾病的易感性:采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)测定 mTOR 单核苷酸多态性(SNP)rs2295080:结果:比较病例和对照组之间的基因型、等位基因和基因型组合频率,结果无显著差异。然而,与无动脉粥样硬化的糖尿病妇女相比,有动脉粥样硬化的糖尿病妇女的 rs2295080 GT + TT 基因型频率明显更高(p = 0.047)。此外,rs2295080 G等位基因在无动脉粥样硬化的糖尿病妇女中的检出率高于有动脉粥样硬化的妇女(P = 0.046):结论:rs2295080 GT + TT 基因型使伊朗女性糖尿病患者易患动脉粥样硬化,而 rs2295080 G 等位基因则使她们免受动脉粥样硬化的影响。不过,要验证这一结果,还需要使用更大样本量进行更多实验。
{"title":"mTOR gene variant rs2295080 might be a risk factor for atherosclerosis in Iranian women with type 2 diabetes mellitus.","authors":"Afsaneh Zare, Shahdad Khosropanah, Gholamreza Daryabor, Mehrnoosh Doroudchi","doi":"10.1186/s12902-024-01703-4","DOIUrl":"10.1186/s12902-024-01703-4","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus, one of the most prevalent metabolic disorders worldwide, is closely linked with an enhanced risk of atherosclerosis. However, the molecular mechanism of this linkage is not still clear. Genetic variations in the mTOR gene may increase the susceptibility of individuals to these diseases.</p><p><strong>Methods: </strong>One hundred nine diabetic patients and 375 healthy subjects participated in this study. mTOR Single Nucleotide Polymorphism (SNP) rs2295080 was determined using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).</p><p><strong>Results: </strong>Comparison of genotypic, allelic, and genotypic combination frequencies between cases and controls revealed no significant result. Nevertheless, the frequency of rs2295080 GT + TT genotype was significantly more in diabetic women with atherosclerosis compared with those without atherosclerosis (p = 0.047). Besides, the rs2295080 G allele was more frequently detected in diabetic women without atherosclerosis compared to those with atherosclerosis (p = 0.046).</p><p><strong>Conclusion: </strong>The rs2295080 GT + TT genotype predisposes Iranian diabetic women to atherosclerosis, while the rs2295080 G allele protects them against atherosclerosis. However, additional experiments using larger sample sizes are needed to verify this result.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"162"},"PeriodicalIF":2.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FPS-ZM1 attenuates the deposition of lipid in the liver of diabetic mice by sterol regulatory element binding protein-1c. FPS-ZM1 通过固醇调节元件结合蛋白-1c 减轻糖尿病小鼠肝脏中的脂质沉积。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-29 DOI: 10.1186/s12902-024-01705-2
Mengshu Zhang, Wanwan Zhao, Zhen Zhang, Mengting He, Ya Zhang, Bing Song, Jinlei Liu, Haoqiang Zhang

Background: Nonalcoholic fatty liver disease (NAFLD) shares common pathogenic mechanisms of type 2 diabetes mellitus (T2DM) with upregulated advanced glycation end products (AGEs). Here, we aim to investigate the effect of FPS-ZM1, an inhibitor for receptor for AGEs (RAGE), on lipid deposition in the liver of mice.

Methods: KK-Ay mice were used as models of T2DM with NAFLD, while C57BL/6j mice were controls. Additionally, KK-Ay mice were treated with DMSO (with a concentration of 1%), with or without FPS-ZM1 (3 mg/kg/day, i.p). Lipid deposition in hepatocytes was observed using oil red O stain. Levels of AGEs and RAGE were measured. Sterol regulatory element-binding protein-1c (SREBP-1c), as well as nuclear factor κB p65 (p65 nfκb) and mitogen-activated protein kinase p38 (p38 MAPK), were also detected.

Results: Lipid deposition is increased in the hepatocytes of KK-Ay mice compared to C57BL/6j mice. In addition, not only were the levels of AGEs elevated in plasma, but also the levels of RAGE in liver tissue. Although total SREBP-1c levels did not change in the liver of diabetic mice, mature SREBP-1c increased in KK-Ay mice with diabetes mellitus. Moreover, diabetic mice showed increased levels of phosphorylated-p65 nfκb (p-p65 nfκb) and phosphorylated-p38 MAPK (p-p38 MAPK). On the contrary, FPS-ZM1 decreased lipid deposition in liver cells, as well as mature SREBP-1c, p-p65 nfκb and p-p38 MAPK levels in liver tissue.

Conclusion: Generally, FPS-ZM1 may attenuate lipid deposition in hepatocytes of diabetic mice via SREBP-1c down-regulation. This may depend on the downregulation of p65 nfκb and p38 MAPK phosphorylation.

背景:非酒精性脂肪肝(NAFLD)与 2 型糖尿病(T2DM)具有共同的致病机制,即高级糖化终产物(AGEs)上调。 在此,我们旨在研究 AGEs 受体(RAGE)抑制剂 FPS-ZM1 对小鼠肝脏脂质沉积的影响:方法:以 KK-Ay 小鼠为 T2DM 伴非酒精性脂肪肝模型,C57BL/6j 小鼠为对照组。此外,用 DMSO(浓度为 1%)处理 KK-Ay 小鼠,同时添加或不添加 FPS-ZM1(3 毫克/千克/天,静注)。使用油红 O 染色法观察肝细胞中的脂质沉积。测量 AGEs 和 RAGE 的水平。还检测了甾醇调节因子结合蛋白-1c(SREBP-1c)以及核因子κB p65(p65 nfκb)和丝裂原活化蛋白激酶 p38(p38 MAPK):结果:与 C57BL/6j 小鼠相比,KK-Ay 小鼠肝细胞中的脂质沉积增加。此外,不仅血浆中 AGEs 的水平升高,肝组织中 RAGE 的水平也升高。虽然糖尿病小鼠肝脏中的总 SREBP-1c 水平没有变化,但患有糖尿病的 KK-Ay 小鼠的成熟 SREBP-1c 水平升高。此外,糖尿病小鼠磷酸化-p65 nfκb(p-p65 nfκb)和磷酸化-p38 MAPK(p-p38 MAPK)的水平也有所增加。相反,FPS-ZM1能减少肝细胞中的脂质沉积,以及肝组织中成熟的SREBP-1c、p-p65 nfκb和p-p38 MAPK水平:总的来说,FPS-ZM1 可通过下调 SREBP-1c 减轻糖尿病小鼠肝细胞中的脂质沉积。结论:总体而言,FPS-ZM1 可通过下调 SREBP-1c 减轻糖尿病小鼠肝细胞的脂质沉积,这可能取决于 p65 nfκb 和 p38 MAPK 磷酸化的下调。
{"title":"FPS-ZM1 attenuates the deposition of lipid in the liver of diabetic mice by sterol regulatory element binding protein-1c.","authors":"Mengshu Zhang, Wanwan Zhao, Zhen Zhang, Mengting He, Ya Zhang, Bing Song, Jinlei Liu, Haoqiang Zhang","doi":"10.1186/s12902-024-01705-2","DOIUrl":"https://doi.org/10.1186/s12902-024-01705-2","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) shares common pathogenic mechanisms of type 2 diabetes mellitus (T2DM) with upregulated advanced glycation end products (AGEs). Here, we aim to investigate the effect of FPS-ZM1, an inhibitor for receptor for AGEs (RAGE), on lipid deposition in the liver of mice.</p><p><strong>Methods: </strong>KK-Ay mice were used as models of T2DM with NAFLD, while C57BL/6j mice were controls. Additionally, KK-Ay mice were treated with DMSO (with a concentration of 1%), with or without FPS-ZM1 (3 mg/kg/day, i.p). Lipid deposition in hepatocytes was observed using oil red O stain. Levels of AGEs and RAGE were measured. Sterol regulatory element-binding protein-1c (SREBP-1c), as well as nuclear factor κB p65 (p65 nfκb) and mitogen-activated protein kinase p38 (p38 MAPK), were also detected.</p><p><strong>Results: </strong>Lipid deposition is increased in the hepatocytes of KK-Ay mice compared to C57BL/6j mice. In addition, not only were the levels of AGEs elevated in plasma, but also the levels of RAGE in liver tissue. Although total SREBP-1c levels did not change in the liver of diabetic mice, mature SREBP-1c increased in KK-Ay mice with diabetes mellitus. Moreover, diabetic mice showed increased levels of phosphorylated-p65 nfκb (p-p65 nfκb) and phosphorylated-p38 MAPK (p-p38 MAPK). On the contrary, FPS-ZM1 decreased lipid deposition in liver cells, as well as mature SREBP-1c, p-p65 nfκb and p-p38 MAPK levels in liver tissue.</p><p><strong>Conclusion: </strong>Generally, FPS-ZM1 may attenuate lipid deposition in hepatocytes of diabetic mice via SREBP-1c down-regulation. This may depend on the downregulation of p65 nfκb and p38 MAPK phosphorylation.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"164"},"PeriodicalIF":2.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum follistatin like 1 in children with obesity and metabolic-associated fatty liver disease. 肥胖症和代谢相关性脂肪肝患儿血清中的类绒毛膜促性腺激素 1。
IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-29 DOI: 10.1186/s12902-024-01702-5
Lujie Liu, Meng Li, Yujie Qin, Luyang Liu, Yanfeng Xiao

Background: Follistatin-like protein 1 (FSTL1) has been identified as a secreted glycoprotein that plays an important role in obesity. However, its role in children with metabolic-associated fatty liver disease (MAFLD) has not been investigated. This study aimed at characterizing the relationship between serum FSTL1 concentration and MAFLD in children with obesity.

Methods: A total of 121 subjects were recruited from the Second Affiliated Hospital of Xi'an Jiaotong University, including 45 obese children with MAFLD, 31 obese children without MAFLD, and 45 healthy controls. Anthropometric parameters, biochemical data were measured and circulating FSTL1 levels were detected by ELISA.

Results: The levels of FSTL1 in obese children with MAFLD were higher than that in obese children without MAFLD: 1.31 (0.35-2.29) ng/mL vs. 0.55 (0.36-1.38) ng/mL. Correlation analysis illustrated that FSTL1 was associated with nonesterified free fatty acid and leptin (r = 0.278, P < 0.05 and r = 0.572, P < 0.05, respectively). Binary logistic regression suggested that increased FSTL1 was a risk factor for MAFLD in children (OR = 1.105, 95% CI: 1.066-1.269, P < 0.05).

Conclusions: Serum FSTL1 concentrations increase in obese children with MAFLD and may have the potential to be a risk factor for MAFLD in children with obesity.

背景:Follistatin-like protein 1(FSTL1)已被确认为一种分泌性糖蛋白,在肥胖症中发挥着重要作用。然而,它在代谢相关性脂肪肝(MAFLD)患儿中的作用尚未得到研究。本研究旨在描述肥胖症儿童血清 FSTL1 浓度与 MAFLD 之间的关系:方法:研究人员从西安交通大学第二附属医院招募了121名受试者,包括45名患有MAFLD的肥胖儿童、31名未患有MAFLD的肥胖儿童和45名健康对照组。研究人员测量了这些儿童的人体测量指标和生化数据,并用ELISA方法检测了循环中FSTL1的水平:结果:患有MAFLD的肥胖儿童的FSTL1水平高于未患有MAFLD的肥胖儿童:1.31(0.35-2.29)纳克/毫升 vs. 0.55(0.36-1.38)纳克/毫升。相关性分析表明,FSTL1 与非酯化游离脂肪酸和瘦素相关(r = 0.278,P 结论:FSTL1 与瘦素的相关性较低:患有MAFLD的肥胖儿童血清中的FSTL1浓度升高,有可能成为肥胖儿童MAFLD的危险因素。
{"title":"Serum follistatin like 1 in children with obesity and metabolic-associated fatty liver disease.","authors":"Lujie Liu, Meng Li, Yujie Qin, Luyang Liu, Yanfeng Xiao","doi":"10.1186/s12902-024-01702-5","DOIUrl":"10.1186/s12902-024-01702-5","url":null,"abstract":"<p><strong>Background: </strong>Follistatin-like protein 1 (FSTL1) has been identified as a secreted glycoprotein that plays an important role in obesity. However, its role in children with metabolic-associated fatty liver disease (MAFLD) has not been investigated. This study aimed at characterizing the relationship between serum FSTL1 concentration and MAFLD in children with obesity.</p><p><strong>Methods: </strong>A total of 121 subjects were recruited from the Second Affiliated Hospital of Xi'an Jiaotong University, including 45 obese children with MAFLD, 31 obese children without MAFLD, and 45 healthy controls. Anthropometric parameters, biochemical data were measured and circulating FSTL1 levels were detected by ELISA.</p><p><strong>Results: </strong>The levels of FSTL1 in obese children with MAFLD were higher than that in obese children without MAFLD: 1.31 (0.35-2.29) ng/mL vs. 0.55 (0.36-1.38) ng/mL. Correlation analysis illustrated that FSTL1 was associated with nonesterified free fatty acid and leptin (r = 0.278, P < 0.05 and r = 0.572, P < 0.05, respectively). Binary logistic regression suggested that increased FSTL1 was a risk factor for MAFLD in children (OR = 1.105, 95% CI: 1.066-1.269, P < 0.05).</p><p><strong>Conclusions: </strong>Serum FSTL1 concentrations increase in obese children with MAFLD and may have the potential to be a risk factor for MAFLD in children with obesity.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"165"},"PeriodicalIF":2.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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BMC Endocrine Disorders
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