Hemochromatosis is caused by p.Cys282Tyr mutations in HFE. This study’s objective was to find causal or disease-related variations in people with erythrocytosis of unknown origin who came from a family with clear blood markers and other indicators of congenital erythrocytosis. This research aims to create a new hemochromatosis risk prediction prototype and evaluate psychographic, clinical, and genomic data to improve predictive model performance. In this review, a conditional characterization of primary iron overload, secondary iron overload, and hemochromatosis medical history is established, as well as an analysis of the drug molecules used to treat hemochromatosis. This paper provides Hemochromatosis Gene brand and its operation.
{"title":"Molecular Genetic of Hemochromatosis Disease using Bioinformatics Tools","authors":"R. K. Mishra","doi":"10.21786/bbrc/15.3.7","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.7","url":null,"abstract":"Hemochromatosis is caused by p.Cys282Tyr mutations in HFE. This study’s objective was to find causal or disease-related variations in people with erythrocytosis of unknown origin who came from a family with clear blood markers and other indicators of congenital erythrocytosis. This research aims to create a new hemochromatosis risk prediction prototype and evaluate psychographic, clinical, and genomic data to improve predictive model performance. In this review, a conditional characterization of primary iron overload, secondary iron overload, and hemochromatosis medical history is established, as well as an analysis of the drug molecules used to treat hemochromatosis. This paper provides Hemochromatosis Gene brand and its operation.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49123168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The potential microalgal strains that are robust and display high growth and lipid accumulation rates are an important prerequisite for using them as a bioenergy source. We have isolated and screened six morphologically different microalgae strains, isolated from the Sabarmati River in Gujarat, India. The growth rates and lipid productivity of all six microalgae were assessed. Three potential microalgae strains were screened based on maximum biomass and lipid production. We named them MA001, MA002 and MA003. We identified MA001 as Micractinium reisseri based on its 28S rRNA sequencing. The M. reisseri showed an optimal growth rate of 2 g/L (dry weight) and 52 % lipid content after 20 days of cultivation in a normal artificial saline medium. Further analysis of lipid accumulation in M. reisseri was investigated at different concentrations of nitrogen. M. reisseri accumulated the highest amount of lipid under nitrogen starvation.
{"title":"Effect of Nitrogen on the Biomass Production and Lipid Accumulation of Micractinium reisseri: A potential Microalgal Strain for Bio-fuel Production","authors":"S. Sahay","doi":"10.21786/bbrc/15.3.11","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.11","url":null,"abstract":"The potential microalgal strains that are robust and display high growth and lipid accumulation rates are an important prerequisite for using them as a bioenergy source. We have isolated and screened six morphologically different microalgae strains, isolated from the Sabarmati River in Gujarat, India. The growth rates and lipid productivity of all six microalgae were assessed. Three potential microalgae strains were screened based on maximum biomass and lipid production. We named them MA001, MA002 and MA003. We identified MA001 as Micractinium reisseri based on its 28S rRNA sequencing. The M. reisseri showed an optimal growth rate of 2 g/L (dry weight) and 52 % lipid content after 20 days of cultivation in a normal artificial saline medium. Further analysis of lipid accumulation in M. reisseri was investigated at different concentrations of nitrogen. M. reisseri accumulated the highest amount of lipid under nitrogen starvation.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47675167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Resistance has been reducing the effectiveness of antibiotics for the past few decades. Researchers are constantly investigating new herbal medicines which can be a better option as well. Aqueous and ethanol extraction method were followed to obtain clove buds and neem twig (datum) extracts. The obtained extracts were tested against selected bacteria using the well diffusion method and broth dilution method to assess the antimicrobial activities. The obtained data were recorded as MIC50 MIC80 and MBC (minimum bactericidal concentration). The tremendous antibacterial activities in extract of Azadirachta indica and Syzygium aromaticum were observed highest in 6.25 mg/mL of ethanol extraction method. It is concluded that neem and clove showed tremendous antimicrobial activities and both have been found quite effective in oral health even today.
{"title":"Potential Impact of Azadirachta indica and Syzygium aromaticum on Growth and Development of Significant Cultivable Oral Bacterial Flora","authors":"Umeshwar Narayan","doi":"10.21786/bbrc/15.3.12","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.12","url":null,"abstract":"Resistance has been reducing the effectiveness of antibiotics for the past few decades. Researchers are constantly investigating new herbal medicines which can be a better option as well. Aqueous and ethanol extraction method were followed to obtain clove buds and neem twig (datum) extracts. The obtained extracts were tested against selected bacteria using the well diffusion method and broth dilution method to assess the antimicrobial activities. The obtained data were recorded as MIC50 MIC80 and MBC (minimum bactericidal concentration). The tremendous antibacterial activities in extract of Azadirachta indica and Syzygium aromaticum were observed highest in 6.25 mg/mL of ethanol extraction method. It is concluded that neem and clove showed tremendous antimicrobial activities and both have been found quite effective in oral health even today.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47231817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this investigation was to establish a HPLC methodology and evaluate Gadobutrol along with impurities A, B and C. The method for Gadobutrol along with impurity-A, B and C analysis was developed on Phenomenex Phenyl-Hexyl C18 column with isocratic elution using mobile phase consisted of formic acid (pH 3.6) and acetonitrile. The method proposed showed a good linearity in the range of 0.8314 – 30.21 ppm (Gadobutrol), 3.2971 – 34.62 ppm (impurity-A), 0.3788 – 34.82 ppm (impurity-B), and 2.9757 – 32.38 ppm for impurity-C. Obtained good method precision (RSD = 2.36% to 3.55%), acceptable accuracy (98.8% to 108.9%), detection limit (0.1250 ppm to 1.0811 ppm) and quantitation limit (0.3788 ppm to 3.2971 ppm) for Gadobutrol and impurity-A, B and C. The method proposed can be utilized to assess the quality of Gadobutrol sample for the presence of impurities A, B and C.
{"title":"Stability Indicating Reverse Phase High-Performance Liquid Chromatography Method for Quantitative Estimation of Impurities in Gadobutrol Solution for Intravenous Administration","authors":"Sanni Babu Najana","doi":"10.21786/bbrc/15.3.10","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.10","url":null,"abstract":"The purpose of this investigation was to establish a HPLC methodology and evaluate Gadobutrol along with impurities A, B and C. The method for Gadobutrol along with impurity-A, B and C analysis was developed on Phenomenex Phenyl-Hexyl C18 column with isocratic elution using mobile phase consisted of formic acid (pH 3.6) and acetonitrile. The method proposed showed a good linearity in the range of 0.8314 – 30.21 ppm (Gadobutrol), 3.2971 – 34.62 ppm (impurity-A), 0.3788 – 34.82 ppm (impurity-B), and 2.9757 – 32.38 ppm for impurity-C. Obtained good method precision (RSD = 2.36% to 3.55%), acceptable accuracy (98.8% to 108.9%), detection limit (0.1250 ppm to 1.0811 ppm) and quantitation limit (0.3788 ppm to 3.2971 ppm) for Gadobutrol and impurity-A, B and C. The method proposed can be utilized to assess the quality of Gadobutrol sample for the presence of impurities A, B and C.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47747935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, 8 meteorological variables were modeled in the Yabú station, Cuba, for which the daily database of this meteorological station was used, where the meteorological variables were taken into account are: extreme temperatures, extreme humidity and its average value, precipitation, wind force and cloudiness corresponding to the period 1977 to 2021. A linear mathematical model was obtained using the Objective Regressive Regression (ORR) methodology for each variable, which explains its behavior according to these variables, 15, 13, 10 and 8 years in advance. The calculation of the mean error with respect to the persistence forecast in temperatures, wind strength and cloudiness, as well as the persistence model was better with respect to humidity, this allows having valuable long-term information of the weather in a locality, which results in better decision making in the different aspects of the economy and society that are impacted by the weather forecast. It is concluded that these models allow long-term weather forecasting, opening a new possibility for forecasting, so that weather chaos can be overcome if this way of forecasting is used; moreover, it is the first time that an ORR model is applied to weather forecasting processes for a specific day so many years in advance.
{"title":"Chaos Theory of Mathematics as seen from a New Perspective for Weather Forecasting","authors":"Ricardo Osés Rodríguez","doi":"10.21786/bbrc/15.3.4","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.4","url":null,"abstract":"In this work, 8 meteorological variables were modeled in the Yabú station, Cuba, for which the daily database of this meteorological station was used, where the meteorological variables were taken into account are: extreme temperatures, extreme humidity and its average value, precipitation, wind force and cloudiness corresponding to the period 1977 to 2021. A linear mathematical model was obtained using the Objective Regressive Regression (ORR) methodology for each variable, which explains its behavior according to these variables, 15, 13, 10 and 8 years in advance. The calculation of the mean error with respect to the persistence forecast in temperatures, wind strength and cloudiness, as well as the persistence model was better with respect to humidity, this allows having valuable long-term information of the weather in a locality, which results in better decision making in the different aspects of the economy and society that are impacted by the weather forecast. It is concluded that these models allow long-term weather forecasting, opening a new possibility for forecasting, so that weather chaos can be overcome if this way of forecasting is used; moreover, it is the first time that an ORR model is applied to weather forecasting processes for a specific day so many years in advance.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42610858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keratinases from Aneurinibacillus aneurinilyticus are capable of degrading keratinous proteins. Salt precipitation and diethylaminoethyly determined the purification and characterization of the enzyme. Ion-exchange and gel permeation chromatography, and SDS-PAGE. Physicochemical factors like pH, temperature, metal ions, enzyme inhibitors and substrate. To study Km and Vmax various concentrations of keratin were used for the activity of enzyme. Gel permeation chromatography with 20.84-fold purification. 203.87 U/mg specific activity showed 34KDa between 14 to 31KDa in SDS-PAGE. The number was stable at pH 7.0-9.0 400-500C, and optimum at pH 9.0 and 500C. Further stimulated by Mg2+, Ca2+, K+, Fe2+, Zn2+, Mn2+, and Na2+ inhibited by Cu2+, Co2+ and Hg2+. Ethylene diamine tetra acetic acid with the highest stimulatory effect was inhibited by Di-isopropyl fluoro phosphatase and phenyl methyl sulfonyl fluoride. Enzyme was stable with Tween-60, TritonX-100 and TritonX-114 declined with ß-mercaptoethanol. It hydrolyzed several keratinous substrates as keratin and casein were 100 and 85.47% utilized with Km=3mM, Vmax =249µmol/ml/min. Xerophytic endophytes are treasure houses as they tolerate biotic and abiotic stress, are stable at high temperatures and pH are selected, such keratinases can be used in leather processing and detergent industries.
{"title":"Purification and Characterization of Keratinase from Aneurinibacillus aneurinilyticus Isolated from a Xerophytic Plant Opuntia ficus-indica","authors":"Sujata S","doi":"10.21786/bbrc/15.3.5","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.5","url":null,"abstract":"Keratinases from Aneurinibacillus aneurinilyticus are capable of degrading keratinous proteins. Salt precipitation and diethylaminoethyly determined the purification and characterization of the enzyme. Ion-exchange and gel permeation chromatography, and SDS-PAGE. Physicochemical factors like pH, temperature, metal ions, enzyme inhibitors and substrate. To study Km and Vmax various concentrations of keratin were used for the activity of enzyme. Gel permeation chromatography with 20.84-fold purification. 203.87 U/mg specific activity showed 34KDa between 14 to 31KDa in SDS-PAGE. The number was stable at pH 7.0-9.0 400-500C, and optimum at pH 9.0 and 500C. Further stimulated by Mg2+, Ca2+, K+, Fe2+, Zn2+, Mn2+, and Na2+ inhibited by Cu2+, Co2+ and Hg2+. Ethylene diamine tetra acetic acid with the highest stimulatory effect was inhibited by Di-isopropyl fluoro phosphatase and phenyl methyl sulfonyl fluoride. Enzyme was stable with Tween-60, TritonX-100 and TritonX-114 declined with ß-mercaptoethanol. It hydrolyzed several keratinous substrates as keratin and casein were 100 and 85.47% utilized with Km=3mM, Vmax =249µmol/ml/min. Xerophytic endophytes are treasure houses as they tolerate biotic and abiotic stress, are stable at high temperatures and pH are selected, such keratinases can be used in leather processing and detergent industries.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44088027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The increase in number of Postpartum Depression (PPD) cases in Kerala is increasing day by day. So, a study on the awareness of PPD has become necessary in this scenario. This study tries to quantify the awareness among women in Kerala about PPD and covers how they tackled the issue through various methods used by them to cope with the issue. The study is conducted using an online survey method. A prepared questionnaire was circulated online among 150 young mothers who were born and brought up in Kerala. The questionnaire consisted of eight questions about PPD and baby blues. Each question was provided with options from which the participants had to choose one. The data thus collected were studied and analyzed. The results of the survey were analyzed to arrive at a conclusion. There was active participation from the participants’ side. The results showed that the percentage of participants who were well aware of PPD was very low. The study brought to light that, much attention and activities are needed to solve PPD cases in Kerala. Most women who suffer from PPD are reluctant to seek medical help. This situation can change through proper campaigns and other related activities.
{"title":"Postpartum Depression among Women in Kerala: A Survey","authors":"P. Prasad","doi":"10.21786/bbrc/15.3.9","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.9","url":null,"abstract":"The increase in number of Postpartum Depression (PPD) cases in Kerala is increasing day by day. So, a study on the awareness of PPD has become necessary in this scenario. This study tries to quantify the awareness among women in Kerala about PPD and covers how they tackled the issue through various methods used by them to cope with the issue. The study is conducted using an online survey method. A prepared questionnaire was circulated online among 150 young mothers who were born and brought up in Kerala. The questionnaire consisted of eight questions about PPD and baby blues. Each question was provided with options from which the participants had to choose one. The data thus collected were studied and analyzed. The results of the survey were analyzed to arrive at a conclusion. There was active participation from the participants’ side. The results showed that the percentage of participants who were well aware of PPD was very low. The study brought to light that, much attention and activities are needed to solve PPD cases in Kerala. Most women who suffer from PPD are reluctant to seek medical help. This situation can change through proper campaigns and other related activities.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43552421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plankton are small microscopic organisms, comprising diatoms and algae, which form the basis of primary production, whereas zooplankton are mainly crustaceans, rotifers and larval stages of larger animals which constitute the higher aquatic food web. Both are bio-indicators of a water body, constituting the main food for the carnivorous and omnivorous fishes in the aquatic ecosystem. In the present work, a detailed analysis of zooplankton diversity along with variations in species, and seasonal abundance with average and total population density was carried out in different types of domestic sewage oxidation ponds. Similar analysis for a comparison was done in a freshwater control pond situated in Bhopal India. In this study out of 8 ponds, 4 were selected for zooplankton analysis two being primary and two being secondary sewage oxidation ponds and one freshwater control pond was selected for comparative analysis. The results indicated that the number of zooplankton in all ponds ranged from 162 to 14776 org/L, seasonally it was observed that the sewage oxidation ponds had the maximum population of zooplankton in winter, followed by rainy and summer seasons. Regarding the population of zooplankton in the individual oxidation ponds, it was found that sewage secondary pond IIIB had the maximum zooplankton followed by IIIA. Interesting observations on the cascading effects of physicochemical parameters on plankton dynamics, including the variations in the diel population of various species of zooplankton have been recorded. The phenomenon of plankton grazing in different types of domestic sewage ponds is being reported for the first time.
{"title":"On the Dominant Behavior of Zooplankton in Different types of Domestic Sewage Oxidation Ponds","authors":"Sharique A. Ali","doi":"10.21786/bbrc/15.3.15","DOIUrl":"https://doi.org/10.21786/bbrc/15.3.15","url":null,"abstract":"Plankton are small microscopic organisms, comprising diatoms and algae, which form the basis of primary production, whereas zooplankton are mainly crustaceans, rotifers and larval stages of larger animals which constitute the higher aquatic food web. Both are bio-indicators of a water body, constituting the main food for the carnivorous and omnivorous fishes in the aquatic ecosystem. In the present work, a detailed analysis of zooplankton diversity along with variations in species, and seasonal abundance with average and total population density was carried out in different types of domestic sewage oxidation ponds. Similar analysis for a comparison was done in a freshwater control pond situated in Bhopal India. In this study out of 8 ponds, 4 were selected for zooplankton analysis two being primary and two being secondary sewage oxidation ponds and one freshwater control pond was selected for comparative analysis. The results indicated that the number of zooplankton in all ponds ranged from 162 to 14776 org/L, seasonally it was observed that the sewage oxidation ponds had the maximum population of zooplankton in winter, followed by rainy and summer seasons. Regarding the population of zooplankton in the individual oxidation ponds, it was found that sewage secondary pond IIIB had the maximum zooplankton followed by IIIA. Interesting observations on the cascading effects of physicochemical parameters on plankton dynamics, including the variations in the diel population of various species of zooplankton have been recorded. The phenomenon of plankton grazing in different types of domestic sewage ponds is being reported for the first time.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48495931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xylanase is a significant enzyme which contributes to the breakdown of xylan and is utilized in an enormous range of biotechnological applications. In the present study, alkaline xylanase was produced using Elephant Foot Yam peels (EFY) in Solid State Fermentation (SSF) by Aspergillus terreus Thom isolated from elephant dung, which was procured from Indore Zoo. The optimization of xylanase production using One Factor at a Time (OFAT) approach exhibited 121 ± 2.5 U/ml of the highest xylanase activity and obtained at 60°C, pH 8.0 in 96 h culture with inoculum size of 1x 106 spores/ml, 90% moisture and 2 mm particle size in SSF. Further, the BBD (Box-Behnken design) based on Statistical software analysis i.e., Response Surface Methodology (RSM) was employed for optimizing xylanase production which predicted 4.2% increase in value which was in concurrence with the investigational design model.
{"title":"Elephant Foot Yam Peels as Substrate for the Production of Alkaline Xylanase from Aspergillus terreus Using Solid State Fermentation","authors":"Richa Nenava","doi":"10.21786/bbrc/15.2.12","DOIUrl":"https://doi.org/10.21786/bbrc/15.2.12","url":null,"abstract":"Xylanase is a significant enzyme which contributes to the breakdown of xylan and is utilized in an enormous range of biotechnological applications. In the present study, alkaline xylanase was produced using Elephant Foot Yam peels (EFY) in Solid State Fermentation (SSF) by Aspergillus terreus Thom isolated from elephant dung, which was procured from Indore Zoo. The optimization of xylanase production using One Factor at a Time (OFAT) approach exhibited 121 ± 2.5 U/ml of the highest xylanase activity and obtained at 60°C, pH 8.0 in 96 h culture with inoculum size of 1x 106 spores/ml, 90% moisture and 2 mm particle size in SSF. Further, the BBD (Box-Behnken design) based on Statistical software analysis i.e., Response Surface Methodology (RSM) was employed for optimizing xylanase production which predicted 4.2% increase in value which was in concurrence with the investigational design model.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44715663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronavirus 2019 (COVID 19) is one of the pandemics registered for 2020, with the entire world affected. COVID 19 disease is diagnosed based on symptoms and risk factors, and both swab and RT-PCR tests are available to confirm the disease. The aim of this study was to the underlying health issues which might be connected to development of severe COVID19.A retrospective study was carried out in a tertiary hospital (Corona center) in Saudi Arabia from August 2020 to December 2020 to identify the risk factors of mortality in ICU admitted COVID-19 patients and to assess the underlining sociodemographic and medical conditions that may lead to the development of severe COVID-19. Data was collected from patients' medical records. In this study, 174 subjects were recruited and 71.3% of the population is male and 28.7% as female. Survival was 52%, whereas non-survivors was 48%. The average age was 57.7±16.0 years old. The most common clinical manifestations were shortness of breath (75.9%), cough (67.8%), and fever (64.9%). T2DM was one of the highest co-morbidities was documented. Binary logistic regression analysis confirmed both the age and fever showed the positive association (p<0.05) and the serum parameters such as CRP, d dimer, neutrophils and lymphocytes showed the elevated levels and positive association (p<0.05). In conclusion, the current study results confirmed HTN, CKD, and heart disease comorbidities all played a substantial impact in the development of COVID-19, and that older age (>60 years) also played a role in COVID 19 patients. Saudi Arabia is one of the nations that has successfully managed the COVID 19.
{"title":"Assessment of Risk Factors for Severe Coronavirus Disease -19 in Taif Province, Saudi Arabia","authors":"Nuha A. Abdelmutalab","doi":"10.21786/bbrc/15.2.10","DOIUrl":"https://doi.org/10.21786/bbrc/15.2.10","url":null,"abstract":"Coronavirus 2019 (COVID 19) is one of the pandemics registered for 2020, with the entire world affected. COVID 19 disease is diagnosed based on symptoms and risk factors, and both swab and RT-PCR tests are available to confirm the disease. The aim of this study was to the underlying health issues which might be connected to development of severe COVID19.A retrospective study was carried out in a tertiary hospital (Corona center) in Saudi Arabia from August 2020 to December 2020 to identify the risk factors of mortality in ICU admitted COVID-19 patients and to assess the underlining sociodemographic and medical conditions that may lead to the development of severe COVID-19. Data was collected from patients' medical records. In this study, 174 subjects were recruited and 71.3% of the population is male and 28.7% as female. Survival was 52%, whereas non-survivors was 48%. The average age was 57.7±16.0 years old. The most common clinical manifestations were shortness of breath (75.9%), cough (67.8%), and fever (64.9%). T2DM was one of the highest co-morbidities was documented. Binary logistic regression analysis confirmed both the age and fever showed the positive association (p<0.05) and the serum parameters such as CRP, d dimer, neutrophils and lymphocytes showed the elevated levels and positive association (p<0.05). In conclusion, the current study results confirmed HTN, CKD, and heart disease comorbidities all played a substantial impact in the development of COVID-19, and that older age (>60 years) also played a role in COVID 19 patients. Saudi Arabia is one of the nations that has successfully managed the COVID 19.","PeriodicalId":9156,"journal":{"name":"Bioscience Biotechnology Research Communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43826052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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