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Role of central and peripheral serotonin in obesity: what to expect in the near pharmacotherapy future? 中枢和外周血清素在肥胖中的作用:近期药物治疗的前景如何?
Pub Date : 2018-11-09 DOI: 10.15406/aowmc.2018.08.00261
Mina T. Kelleni
serotonin plays a role in obesity pathogenesis, but also peripheral serotonin was suggested to play an important role in obesity, and evidence from animal studies has demonstrated 5-HT ability to regulate glucose and lipid metabolism by accelerating energy consumption in skeletal muscle. Further, gut-derived 5-HT was likely suggested to be an important driver of pathogenesis in human obesity as well as in dysglycemia4,5 and several genetic polymorphisms in tryptophan hydroxylase and 5-HT receptors were shown to have strong associations with obesity. Moreover, peripheral 5-HT was shown to suppress the adaptive thermo genesis in brown adipose tissue and the peripheral serotonergic system was marked as a therapeutic target for both obesity and diabetes.6 Lorcaserin, 5-HT2 receptor agonist, and its potential under development more specific congeners with lower adverse effects, suppress the appetite and reduce body weight gain and are considered as promising therapeutic tools for obesity7 while antagonism of 5-HT2c receptor has been identified as a main cause of second generation antipsychotics induced weight gain and obesity.8 On the other hand, obesity increases peripheral serotonin and inhibiting serotonin signaling or its synthesis in adipose tissue may be an effective treatment for obesity and its comorbidities.9
5-羟色胺在肥胖发病机制中发挥重要作用,但外周血清素也被认为在肥胖中发挥重要作用,动物研究证据表明5-羟色胺能够通过加速骨骼肌的能量消耗来调节葡萄糖和脂质代谢。此外,肠道来源的5-羟色胺可能是人类肥胖和血糖异常发病的重要驱动因素,色氨酸羟化酶和5-羟色胺受体的几种遗传多态性被证明与肥胖密切相关。此外,外周5-羟色胺被证明可以抑制棕色脂肪组织的适应性产热,外周血清素能系统被标记为肥胖和糖尿病的治疗靶点氯卡色林,5-HT2受体激动剂,及其潜在的开发更特异的同源物,更低的副作用,抑制食欲和减少体重增加,被认为是有前途的治疗肥胖的工具7,而5-HT2c受体的拮抗作用已被确定为第二代抗精神病药物诱导体重增加和肥胖的主要原因8另一方面,肥胖增加外周血清素,抑制血清素信号传导或其在脂肪组织中的合成可能是治疗肥胖及其合并症的有效方法
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引用次数: 1
Frequency of underweight in Saudi adults 沙特成年人体重不足的频率
Pub Date : 2018-11-07 DOI: 10.15406/AOWMC.2018.08.00260
K. Aljabri, S. Bokhari, Muneera Alshareef, Patan Murthuza Khan, Hesham Abu Alsaoud, Mohammad M Jalal, Rania F Safwat, Rehab Borae, ari K Aljabri
Metabolic syndrome (MetS) is a cluster of metabolic factors. MetS was initially observed in 1923 by Kyln, who described the clustering of hypertension, hyperglycaemia and gout as the syndrome.1 The first official definition of MetS put forward by a working group of the World Health Organization (WHO) in 1999, a number of different definitions have been proposed. There have been several definitions of MetS, but the most commonly used criteria for definition at present are from the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), the International Diabetes Federation (IDF), and the World Health Organization (WHO).2−4
代谢综合征(MetS)是一组代谢因子。1923年,Kyln首次观察到MetS,他将高血压、高血糖和痛风的聚集性描述为综合征世界卫生组织(世卫组织)的一个工作组于1999年提出了MetS的第一个正式定义,此后提出了许多不同的定义。MetS有多种定义,但目前最常用的定义标准来自国家胆固醇教育计划(NCEP)成人治疗小组III (ATP III)、国际糖尿病联合会(IDF)和世界卫生组织(WHO)
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引用次数: 1
Why are we seeing so many more children diagnosed with food allergies? 为什么我们看到越来越多的孩子被诊断为食物过敏?
Pub Date : 2018-10-19 DOI: 10.15406/AOWMC.2018.08.00259
T. DeLorenzo
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引用次数: 0
Evaluation of meals served in state registered childcare settings 对国家注册儿童保育机构提供的膳食进行评估
Pub Date : 2018-10-15 DOI: 10.15406/aowmc.2018.08.00258
Beverly M Copel, S. McWhinney, A. Osonkie
Obesity in adults and children has been a problem throughout modern history but only in the past 30years has it increased to epidemic proportions. It is evident that during the past three decades the proportion of obese children became nearly tripled across all age groups. Estimation from the 2011-2012 National Health and Nutrition Examination Survey (NHANES) indicated that 17% of children and adolescents ages 2-19 years are overweight.1
成人和儿童肥胖一直是现代历史上的一个问题,但直到过去30年,它才上升到流行病的程度。很明显,在过去三十年中,肥胖儿童的比例在所有年龄组中几乎增加了两倍。2011-2012年全国健康和营养检查调查(NHANES)的估计表明,17%的2-19岁儿童和青少年超重
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引用次数: 0
Health risk of adolescents in the rural and urban environment: integrative review 农村和城市环境中青少年的健康风险:综合评价
Pub Date : 2018-10-11 DOI: 10.15406/AOWMC.2018.08.00256
A. Mendes, Elisabete Mendes, Hugo Caldeira, Laura Gomes, Patrícia Lima, Eva Menino, Stefanie Francisco, A. Corte
Studies about the risks of adolescents in rural and urban areas so far are still very rudimentary, so this integrative review is very attractive and bearing in mind that in the near future these young people will be the future of the communities. Community actions aimed at the promotion, health protection and identification of community care needs in their different dimensions require that health professionals have a proactive approach. Adolescence is a phase of life characterized by biological, physical, psychological and social transformations that can affect daily activities of life. It has been found that young people do not follow the daily recommendations of physical activity proposed by the World Health Organization (2016).
到目前为止,关于农村和城市地区青少年风险的研究仍然非常初级,因此,这项综合审查非常有吸引力,并记住,在不久的将来,这些年轻人将成为社区的未来。旨在促进、保护健康和确定不同层面的社区护理需求的社区行动要求保健专业人员采取积极主动的做法。青春期是一个以生物、身体、心理和社会变化为特征的生命阶段,这些变化可以影响日常生活活动。研究发现,年轻人没有遵循世界卫生组织(2016年)提出的每日身体活动建议。
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引用次数: 2
Efficacy of azilsartan and telmisartan in patients with type 2 diabetes and hypertension 阿齐沙坦与替米沙坦治疗2型糖尿病合并高血压的疗效观察
Pub Date : 2018-10-11 DOI: 10.15406/AOWMC.2018.08.00257
Kooshana Vinay Kumar, Penthala Prashanth Reddy, aru Siva Subrahmanyam, E. Venkateshwarlu, aru Sheshagiri Sharvana Bhava
Hypertension is defined as high blood pressure or a long term medical condition in which the arterial blood pressure is continuously elevated.1 It is also explained as sustained diastolic BP more than 90mmHG accompanied by the elevated systolic BP more than 140mmHg.2 Diabetes mellitus is a disorder related with a wide variety of disorders in metabolism, the principal feature is hyperglycaemia caused by inadequate insulin action.3 Most deaths(43%) fall out below 70years of age. 422million people across the globe in 2014 had diabetes-with a 8.5% prevalence in adults.1.5million deaths in 2012 occurred due to diabetes. In 2012 among both genders it is the eighth major cause of death and fifth prime cause of death in woman. About 2,82,000 intensive care room visits for adult population aged 18 years and above encountered hypoglycaemia as an initial diagnosis and diabetes as secondary diagnosis in 2012.4 In the past 30 years Diabetes prevalence consistently inclining and is increasing most rapidly in nations with low and middle income. Increasing concomitant risk factors like being overweight or obese are seen. Diabetes mellitus is a main reason for blindness and kidney failure, legs amputation and other chronic consequences that affect primarily on quality of life.5
高血压被定义为高血压或一种动脉血压持续升高的长期疾病它也可以解释为持续舒张压大于90mmHG,并伴有收缩压升高大于140mmhg糖尿病是一种与多种代谢紊乱有关的疾病,其主要特征是胰岛素作用不足引起的高血糖大多数死亡(43%)发生在70岁以下。2014年,全球有4.22亿人患有糖尿病,其中成人患病率为8.5%,2012年有150万人死于糖尿病。2012年,在两性中,它是第八大死因,也是妇女的第五大死因。2012年,18岁及以上的成年人约有282,000次重症监护室就诊,首次诊断为低血糖,继发诊断为糖尿病。在过去的30年里,糖尿病患病率一直呈下降趋势,并且在低收入和中等收入国家增长最快。越来越多的伴随风险因素,如超重或肥胖。糖尿病是导致失明、肾衰竭、截肢和其他慢性后果的主要原因,这些慢性后果主要影响生活质量
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引用次数: 1
The effect of cigarette type on anthropometrics and weight of PLWH 香烟类型对PLWH人体测量学和体重的影响
Pub Date : 2018-10-02 DOI: 10.15406/AOWMC.2018.08.00255
M. Míguez, Calonie M. K. Gray, Clery Quiros, C. Perez
Relying on evidence that smokers tend to weigh less than nonsmokers, tobacco companies have used several strategies to take advantage of, and manipulate, people’s concern with weight.1,2 Their goal became the addition of active agents to target “non-smokers who are more concerned with losing weight than with contracting respiratory or blood circulatory illnesses. [...] (Bates no. 2056159412).2 While initially focusing on appetite suppressants, later companies began considering “Specific Appetite Inducers”.2 Documents indicated that they were experimenting with “special herbs or medications in a cigarette form as appetite stimulants or possibly for tension release”.2 The list included tartaric acid, 2-Acethylpyridine, catecholamine, menthol, mariolide, propylene glycol and reserpine. They were aware that appetite can be strongly influenced by both aromatic and taste characteristics of the compounds, and inquired about menthol.3 Note worthy, experts indicated that menthol had reached inconclusive effects. Yet, menthol’s other characteristics (e.g. odor, taste, and flavor) let to its inclusion and marketing.2,4 Although several decades have passed since the introduction of mentholated cigarettes to the market, the burgeoning literature is notable for the scarcity of studies examining the plausible effect of mentholated cigarettes on weight.5 A recent insurgence of concern over the safety of this additive, and its potential relationship with weight gain, has prompted further research.6
有证据表明,吸烟者的体重往往比不吸烟者轻,烟草公司利用了几种策略来利用和操纵人们对体重的关注。1,2他们的目标是添加活性药物,以“那些更关心减肥而不是呼吸系统或血液循环疾病的非吸烟者”为目标。[…(贝茨没有。2056159412)。2虽然最初专注于食欲抑制剂,但后来的公司开始考虑“特定食欲诱导剂”文件表明,他们正在试验“以香烟形式制成的特殊草药或药物,以刺激食欲或可能缓解紧张”其中包括酒石酸、2-乙酰吡啶、儿茶酚胺、薄荷醇、薄荷内酯、丙二醇和利血平。他们意识到食欲会受到化合物的芳香和味道特性的强烈影响,并询问了薄荷醇值得注意的是,专家指出薄荷醇的效果还不确定。然而,薄荷醇的其他特性(如气味、味道和风味)阻碍了它的推广和营销。尽管薄荷香烟进入市场已经过去了几十年,但值得注意的是,关于薄荷香烟对体重的合理影响的研究很少近来,人们对这种添加剂的安全性及其与体重增加的潜在关系越来越关注,这促使人们进行进一步的研究
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引用次数: 0
Laparoscopic and robotic ventral hernia repair in obese and morbidly obese patients: initial experience and review of the literature 腹腔镜和机器人腹疝修补在肥胖和病态肥胖患者:初步经验和文献回顾
Pub Date : 2018-10-01 DOI: 10.15406/AOWMC.2018.08.00254
Hirides S, Verveniotis N, Galanopoulou R, Metaxas P, Polyzou A, Hirides P
According to latest literature laparoscopic repair of large parietal wall defects is a well-accepted and safe option for class II and class III obesity patients. Apart from cardiorespiratory and anesthesiological parameters, main concerns with such patients include the relatively higher risks of wound infections and recurrencies as well as postoperative hemorrhage and port-site hernias. However, advantages over classic – open repairs are well demarcated in the literature. Recent introduction of robotics in bariatric as well as hernia surgery brings up new hopes for expansion of the indications to patients with very large incisional hernias and loss of domain. Our aim in this paper is to present a single surgeon’s technique with laparoscopic and robotic parietal wall defect repairs in morbidly obese patients and review latest literature for main concerns of a novice team.
根据最新文献,腹腔镜修复大壁壁缺陷是一种被广泛接受和安全的选择,用于II级和III级肥胖患者。除了心肺和麻醉参数外,这类患者的主要问题包括相对较高的伤口感染和复发风险,以及术后出血和肝部位疝。然而,与经典的开放式修复相比,其优势在文献中有很好的界定。最近机器人技术在减肥和疝气手术中的应用,为大切口疝气和领域丧失患者扩大适应症带来了新的希望。我们的目的是在本文中介绍一个外科医生的技术与腹腔镜和机器人顶壁缺损修复的病态肥胖患者,并回顾最新的文献主要关注的新手团队。
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引用次数: 0
Pregnant women with morbid obesity: pregnancy and perinatal outcomes 病态肥胖孕妇:妊娠和围产期结局
Pub Date : 2018-09-26 DOI: 10.15406/aowmc.2018.08.00253
A. Catena, Nerea Ruiz Sacedón, E. O. Murillo, Reyes Balanzá Chancosa
The aim of this study is to evaluate obstetric complications and perinatal outcomes in 7 pregnant women with morbid obesity (BMI ? 40.0 kg/m²) compared to pregnant women with 8 normal weight (BMI 18.5-24.9 kg/m²). It is a retrospective case-control study undertaken by 9 the Department of Obstetrics at Hospital Universitario Doctor Peset, Valencia (Spain) between 10 May 2008 and July 2016. A total of 50 patients were included in each study group. Morbidly 11 obese pregnant patients had a higher rate of nulliparity (P = 0.03), chronic hypertension (P = 12 0.008), preeclampsia (P = 0.03), gestational diabetes (P = 0.013) and delivery by caesarean 13 section (P = 0.04) compared to control patients with normal weight. A closer monitoring of 14 morbidly obese pregnant women is recommended to prevent, reduce and properly handle the 15 complications that may arise during pregnancy, both for the mother and the fetus.
本研究的目的是评估7例病态肥胖孕妇的产科并发症和围产期结局。40.0 kg/m²),与正常体重(BMI 18.5-24.9 kg/m²)的孕妇相比。这是一项回顾性病例对照研究,由西班牙巴伦西亚佩塞特医生大学医院产科于2008年5月10日至2016年7月期间开展。每个研究组共纳入50例患者。与体重正常的对照组相比,病态肥胖孕妇的无产率(P = 0.03)、慢性高血压(P = 12 0.008)、先兆子痫(P = 0.03)、妊娠期糖尿病(P = 0.013)和剖宫产率(P = 0.04)均较高。建议对14名病态肥胖孕妇进行更密切的监测,以预防、减少和妥善处理怀孕期间可能出现的15种并发症,对母亲和胎儿都是如此。
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引用次数: 1
Obesity, depression, and alcohol linkages among women 女性肥胖、抑郁和酗酒的关系
Pub Date : 2018-09-05 DOI: 10.15406/AOWMC.2018.08.00252
R. Marks
Despite the paucity of data pertaining to the current topics of interest, some of these research efforts do show women tend to be more vulnerable than men in terms of becoming or being obese, especially with regards to extreme obesity,6 although reasons for this are not clear. However, because women also show greater levels of disability from complications related to obesity, some studies have specifically focused on examining gender-related factors that may explain women’s higher rates of obesity. In this regard some data point to the presence of depression or depressive symptoms, given that for every age group, women with depression appear more likely to be obese than women without depression. The proportion of adults with obesity also rose as the severity of depressive symptoms increased in a related analysis.8 Other data showed 55% of adults taking antidepressant medications, still reported moderate to severe depressive symptoms, and were obese, suggesting other obesity associated factors should be explored. One that has also been explored is alcohol.
尽管缺乏与当前感兴趣的话题相关的数据,但其中一些研究确实表明,在变得或变得肥胖方面,女性往往比男性更容易受到伤害,尤其是在极度肥胖方面,6尽管原因尚不清楚。然而,由于女性也表现出与肥胖有关的并发症的更大程度的残疾,一些研究特别关注于检查与性别有关的因素,这些因素可能解释了女性肥胖率较高的原因。在这方面,一些数据表明存在抑郁或抑郁症状,因为在每个年龄组中,患有抑郁症的妇女似乎比没有抑郁症的妇女更容易肥胖。在一项相关分析中,成年人肥胖的比例也随着抑郁症状的严重程度增加而上升其他数据显示,55%的成年人服用抗抑郁药物,仍然报告中度至重度抑郁症状,并且肥胖,这表明应该探索其他与肥胖相关的因素。其中一个也被研究过的是酒精。
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引用次数: 1
期刊
Advances in obesity, weight management & control
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