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Carcinoid Syndrome: Overview and Clinical Approach 类癌综合征:概述和临床方法
Pub Date : 2023-11-06 DOI: 10.19080/arr.2023.10.555783
Maria Isabel Gomez
Annals of Reviews & Research open access journal that publishes high-quality solicited and unsolicited articles, from various types of subject areas ranging from management to engineering sciences, accounting, criminal sciences, etc. which deal with innovative research work.
Annals of Reviews & Research开放获取期刊,发表高质量的应邀和非应邀文章,涉及管理、工程科学、会计、刑事科学等不同类型的学科领域,涉及创新研究工作。
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引用次数: 0
Bio Actives from Albizia Lebbeck on Acute Lung Injury/ Acute Respiratory Distress Syndrome Molecular Targets: In-Silico Study 紫花苜蓿生物活性对急性肺损伤/急性呼吸窘迫综合征分子靶点的计算机研究
Pub Date : 2022-02-01 DOI: 10.19080/arr.2022.07.555703
Y. Tripathi
This contemporary work is prepared with the aim of presenting natural phytoconstituents obtained from Albizia lebbeck (Bronco T) as a remedial option against Acute Lung Injury / Acute Respiratory Distress Syndrome (ARDS). The early onset of non-cardiogenic edema and subsequent gas-exchange impairment caused by a severe inflammatory process known as cytokine storm is acute respiratory distress syndrome (ARDS). The existing strategy includes mechanical ventilation and glucocorticosteroid. However, they pose problems like diaphragm atrophy and down regulated immune response of the host in the lungs of patients with acute respiratory distress syndrome (ARDS), the nuclear regulatory factor NF-kappaB and TLR-4 is activated, which may contribute to increased expression of immune regulatory cytokines and other pro inflammatory mediators including IL-6 and TNF-alpha. Natural products play a pivotal role as it offers minimal and in some cases no toxicity. Albizia lebbeck is the folk language and is known for its anti-inflammatory properties. Targeting the above-mentioned receptors with bioactives from Albizia lebbeck would down regulate the signaling pathway and its associated mediators in ARDS. Through in- silico study including molecular docking, ADMET and Lipinski analysis, we are trying to narrow down the active phytoconstituent from Albizia lebbeck against ARDS.
这项当代工作的目的是展示从合欢(Bronco T)中获得的天然植物成分,作为对抗急性肺损伤/急性呼吸窘迫综合征(ARDS)的治疗选择。由被称为细胞因子风暴的严重炎症过程引起的非心源性水肿和随后的气体交换障碍的早期发作是急性呼吸窘迫综合征(ARDS)。现有的策略包括机械通气和糖皮质激素。然而,它们带来了一些问题,如膈肌萎缩和急性呼吸窘迫综合征(ARDS)患者肺部宿主免疫反应下调,核调节因子NF-κB和TLR-4被激活,这可能有助于免疫调节细胞因子和其他促炎介质(包括IL-6和TNF-α)的表达增加。天然产品发挥着关键作用,因为它的毒性很小,在某些情况下没有毒性。合欢是一种民间语言,以其抗炎特性而闻名。用合欢生物活性物质靶向上述受体将下调ARDS中的信号通路及其相关介质。通过分子对接、ADMET和Lipinski分析等计算机研究,我们试图缩小合欢抗ARDS的活性植物成分。
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引用次数: 0
"Protecting the Frontline: An Assessment on the Occupational Factors Contributing to Covid-19 Nosocomial Infections at Levy Mwanawasa University Teaching Hospital, Zambia" “保护一线:赞比亚利维姆瓦纳瓦萨大学教学医院Covid-19医院感染职业因素评估”
Pub Date : 2021-10-04 DOI: 10.19080/arr.2021.06.555698
Kooma Kh
Everywhere in the world, health workers are at the frontline of the Covid-19 pandemic response and as such are exposed to different hazards (nosocomial infections) that make them at risk. The hospital working environment is complex and demanding and can pose significant risks to staff safety WHO [1]. Occupational Health and Safety (OHS) covers staff health, safety and welfare in the workplace. OHS is particularly important in public hospitals because major hazards exist-such as exposure to infections and chemical agents, manual handling of patients and materials, ships, trips, falls and occupational violence. These hazards can lead to Covid-19 noso-comial infections. Covid-19 was confirmed in Zambia on the 18th March,2020 with a total of 202,078 cases,193,370 (97%) recoveries and 3,521 deaths have been recorded as at 13th August, 2021 HMIS [2]. The severe acute respiratory syndrome coronavirus 2 (SARS-COVI-2) pandemic has been continuing to take a heavy toll on human life spreading to new communities even as its fire appears to have dwindled somewhat in the earlier epi-centers of the country. However, the disease situation in the country has continued to improve with a further 21% reduction in positivity recorded in the past weeks prior to the first week of August 2021. In addition, daily admissions and deaths have significantly reduced over the month of July,2021 from an average of 150 to 30 and from 55 to 10 respectively HMIS [2]. Abstract
在世界各地,卫生工作者都处于应对Covid-19大流行的第一线,因此面临着使他们面临风险的各种危害(医院感染)。医院的工作环境复杂而苛刻,可能对工作人员的安全构成重大风险。职业健康与安全(OHS)涵盖工作场所工作人员的健康、安全和福利。职业健康安全在公立医院尤其重要,因为存在重大危险,如接触感染和化学制剂、人工处理病人和材料、船舶、旅行、跌倒和职业暴力。这些危害可导致Covid-19院内感染。2019冠状病毒病于2020年3月18日在赞比亚确诊,截至2021年8月13日,共记录202,078例病例,193,370例(97%)康复,3,521例死亡。严重急性呼吸系统综合征冠状病毒2 (SARS-COVI-2)大流行继续对人类生命造成严重损害,并蔓延到新的社区,尽管该国早期的疫情中心的火势似乎有所减少。然而,该国的疾病情况继续改善,在2021年8月第一周之前的过去几周内,阳性病例进一步减少了21%。此外,2021年7月,每日入院人数和死亡人数分别从平均150人减少到30人,从55人减少到10人。摘要
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引用次数: 0
"A Phytonutrient Based Brain Activation Complex and Short-Term Brain Function Changes: An Initial Investigation" 基于植物营养素的脑激活复合物和短期脑功能改变:初步研究
Pub Date : 2021-08-11 DOI: 10.19080/arr.2021.06.555697
N. Wolkodoff
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引用次数: 1
Professional Development Needs in a Virtual Teaching and Learning Environment 虚拟教学环境下的专业发展需求
Pub Date : 2021-07-14 DOI: 10.19080/arr.2021.06.555695
Sang E Park
Introduction: The purpose of the study was to evaluate the faculty perspectives in a virtual teaching and learning environment during the COVID-19 pandemic. Methods: This was a survey-based study of ladder faculty members at Harvard School of Dental Medicine (HSDM) investigating information on the challenges and adaptations in teaching methods that were made related to the COVID-19 pandemic. It also questioned the preferred types, length, times and content of faculty development programs. Results: The results showed that a majority (n = 31, 75.6%) of the 56 total participants felt the move to remote learning have Some Impact or Major Impact on the effectiveness of their teaching. Some of the major concerns that faculty expressed were ‘Engagement with students’ (n = 30, 41.67%) and ‘Use of technology’ (n = 16, 22.2%). Also, ‘Designing for online learning’, ‘Classroom technology’ and ‘Poll Everywhere’ were the topics that many faculty members responded found Very Interested. The majority (n = 44, 62.8%) of respondents preferred the online format rather than the in-person format in terms of faculty development program offerings. Conclusion : In order to adapt into the new virtual learning environment, robust faculty development programs should support the continuous designing of pedagogical approaches for a dynamic dental curriculum that will continue to challenge the students and engage the faculty.
本研究的目的是评估在COVID-19大流行期间虚拟教学和学习环境中的教师观点。方法:对哈佛大学牙科医学院(HSDM)的阶梯教师进行了一项基于调查的研究,调查了与COVID-19大流行相关的教学方法的挑战和调整信息。它还质疑了教师发展项目的首选类型、长度、时间和内容。结果:结果显示,56名参与者中的大多数(n = 31, 75.6%)认为远程学习对他们的教学效果有一定影响或主要影响。教师表达的一些主要担忧是“与学生的互动”(n = 30, 41.67%)和“技术的使用”(n = 16, 22.2%)。此外,“在线学习设计”、“课堂技术”和“无处不在的投票”是许多教师非常感兴趣的话题。大多数(n = 44,62.8%)的受访者在教师发展项目方面更喜欢在线形式而不是面对面的形式。结论:为了适应新的虚拟学习环境,强大的教师发展计划应该支持不断设计动态牙科课程的教学方法,这将继续挑战学生并吸引教师。
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引用次数: 0
Oxidative Stress and Inflammatory Biomarkers Analysis of Biofield Treated Proprietary Test Formulation in Heart Tissues in Cecal Slurry, LPS and E. Coli-induced Systemic Inflammatory Response Syndrome (SIRS) in Sprague Dawley Rats 大鼠盲肠浆液、LPS和大肠杆菌诱导的全身炎症反应综合征(SIRS)心脏组织氧化应激和炎症生物标志物分析
Pub Date : 2021-07-13 DOI: 10.19080/arr.2021.06.555694
S. Jana
The study was aimed to evaluate the antioxidant and anti-inflammatory biomarkers in heart tissues after treatment with the Biofield Energy Treated Proprietary Test Formulation and Biofield Energy Treatment per se to the animals on Cecal Slurry, LPS and E. coli -induced systemic inflammatory response syndrome (SIRS) model in Sprague Dawley rats. In this experiment, different antioxidants biomarkers such as myeloperoxidase (MPO), superoxide dismutase (SOD), lipid peroxidase (LPO) and proinflammatory cytokines such as tumor necrosis factor-α (TNF- α), interleukin-6 (IL-6), macrophage inflammatory protein-2 (MIP-2), and matrix metallopeptidase G8, and G9 groups, respectively as compared to the G4 group. Altogether, the data imply the antioxidant and anti-inflammatory potential of the Biofield Energy Treated test formulation and Biofield Energy Treatment per se along with preventive measure on the animal with respect to various inflammatory conditions that might be beneficial various types of systemic inflammatory disorders specially sepsis, trauma, septic shock or any types of cardiac injuries. Therefore, the results showed the significant slowdown the inflammation-related disease progression and its complications/symptoms in the preventive Biofield Energy Treatment group per se and/or Biofield Energy Treated Test formulation groups (viz. G6, G7, G8, and G9) comparatively with the disease control group.
本研究旨在评估在Sprague-Dawley大鼠Cecal淤浆、LPS和大肠杆菌诱导的全身炎症反应综合征(SIRS)模型上,用Biofield Energy Treated Proprietary Test Formula和Biofield Energy treatment本身治疗动物后,心脏组织中的抗氧化和抗炎生物标志物。在本实验中,与G4组相比,不同的抗氧化剂生物标志物,如髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、脂质过氧化物酶(LPO)和促炎细胞因子,如肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、巨噬细胞炎症蛋白-2(MIP-2)和基质金属肽酶G8和G9组。总之,这些数据表明了生物场能量治疗试验制剂和生物场能量处理本身的抗氧化和抗炎潜力,以及对动物的各种炎症条件的预防措施,这些条件可能有益于各种类型的全身炎症疾病,特别是败血症、创伤、感染性休克或任何类型的心脏损伤。因此,结果显示,与疾病对照组相比,预防性生物场能量治疗组本身和/或生物场能量处理测试制剂组(即G6、G7、G8和G9)的炎症相关疾病进展及其并发症/症状显著减缓。
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引用次数: 0
A Brief Correspondence on Glyphosate Remediation using Microbes and Mineral Sources 微生物和矿物资源对草甘膦修复的简要对应
Pub Date : 2021-05-20 DOI: 10.19080/arr.2021.06.555693
A. H. Gondal
Glyphosate is a non-selective herbicide used to control a large variety of annual and perennial weeds. Its pervasive use, however, has harmful implications for living things and the environment. Aside from that, it affects aquatic ecosystems and soil microbial biota, resulting in a loss of soil fertility and, therefore, reduced plant growth and production, all of which has an effect on the food chain. Various techniques have been used to exclude glyphosate from contaminated habitats, but microbial depletion and the use of nitrogen, phosphorus, and plant growth regulators, as well as the use of glyphosate resistant crops, either singly or in combination, are the most environmentally sustainable and cost-effective options. Microbes release basic elements in the soil by their enzymatic processes, and they play an important role in improving plant growth and phytoremediation capacity by lowering the total toxicity of a pollutant to plants. Furthermore, dehydrogenase and urease processes, which are known to be the most critical measures of overall microbial development, are greatly influenced by nitrogen and phosphate fertilizers. In addition, plant growth regulators improve the glyphosate contaminated soil as well. The present review discusses the glyphosate effects and its possible solution in terms of organic and inorganic amendments.
草甘膦是一种非选择性除草剂,用于控制大量一年生和多年生杂草。然而,它的广泛使用对生物和环境产生了有害影响。除此之外,它还会影响水生生态系统和土壤微生物生物群,导致土壤肥力下降,从而减少植物生长和产量,所有这些都会对食物链产生影响。已经使用了各种技术将草甘膦从受污染的栖息地中排除,但微生物耗竭和氮、磷和植物生长调节剂的使用,以及单独或组合使用抗草甘膦作物,是最具环境可持续性和成本效益的选择。微生物通过其酶促过程在土壤中释放基本元素,通过降低污染物对植物的总毒性,在提高植物生长和植物修复能力方面发挥着重要作用。此外,众所周知,脱氢酶和脲酶过程是微生物整体发育的最关键指标,它们在很大程度上受到氮肥和磷肥的影响。此外,植物生长调节剂还改善了草甘膦污染的土壤。本综述从有机和无机改良剂的角度讨论了草甘膦的影响及其可能的解决方案。
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引用次数: 3
Utilization of ActiGraft, an Autologous (Blood Clot) Graft in the Reconstruction of Soft Tissue Deficit from Hand Trauma – A Case Study ActiGraft,一种自体(血块)移植物在手部创伤软组织缺损重建中的应用——一个案例研究
Pub Date : 2021-05-07 DOI: 10.19080/arr.2021.06.555692
Chinenye D Wachuku
The reconstruction of complex soft tissue deficits is associated with great difficulty. When treating intricate structures of the hand, optimal reconstruction is necessary to preserve the function and aesthetics of the hand, preferably to the level associated with preinjury. The mechanism of scar formation is a process that is targeted by many researchers in an attempt to lessen both clinical and financial burden. Excessive hypertrophic tissue can cause adverse events, such as obstruction of vital structures, tendons and nerves, which can reduce the overall function of the hand and the patient’s quality of life. ActiGraft, an autologous blood clot, provides effective wound healing and reconstruction of soft tissue, whilst mitigating hypertrophic scar tissue. ActiGraft expedited the process of revitalization of the wound by promoting ingrowth of healthy granulation tissue and reduction in excessive scar tissue formation. Here we present a case of ActiGraft treatment utilized weekly to promote soft tissue reconstruction of the hand, as well as modification of the mechanism required for scar tissue accumulation. Blood was withdrawn from the patient, at the point-of-care, to create a blood clot that was applied to the wound area. This treatment exhibited significant promotion of granulation tissue ingrowth, repairing the injured soft tissue and skin deficit. ActiGraft was found to be a cost-effective treatment that provided optimal and effective healing of the deficit related to the trauma of the hand.
复杂软组织缺损的重建具有很大的困难。当治疗手部复杂的结构时,最佳的重建是必要的,以保持手部的功能和美观,最好达到损伤前的水平。疤痕形成的机制是许多研究人员试图减轻临床和经济负担的一个过程。过度的组织肥大会引起不良事件,如重要结构、肌腱和神经的阻塞,从而降低手部的整体功能和患者的生活质量。ActiGraft是一种自体血凝块,能有效愈合伤口,重建软组织,同时减轻增生性瘢痕组织。ActiGraft通过促进健康肉芽组织的生长和减少过度疤痕组织的形成,加速了伤口的再生过程。在这里,我们报告了一例每周使用ActiGraft治疗来促进手部软组织重建,以及修改疤痕组织积累所需的机制。在护理点,从病人身上抽血,形成一个血凝块,应用于伤口区域。该处理能显著促进肉芽组织长入,修复损伤软组织和皮肤缺损。研究发现,ActiGraft是一种具有成本效益的治疗方法,可为手部创伤相关的缺损提供最佳和有效的愈合。
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引用次数: 1
Analysis of the Hydrogeological Processes formation Condition in the Baku City Zone and Evaluation of the Subsoil Waters Suitability for Verdures Irrigation for Using 巴库城区水文地质过程形成条件分析及灌区地下水适宜性评价
Pub Date : 2021-04-26 DOI: 10.19080/arr.2021.06.555691
Mammadova Esmiralda
The article is dedicated to the analysis of the hydrogeological process’s formation condition in the Baku city zone and evaluation of the subsoil waters suitability for verdures irrigation. It was determined that a quality of the subsoil waters is suitable for the verdure irrigation in the central, eastern and western parts of the zone, but it is unfit in the northern, north-eastern and south-western parts - local areas of the region. The regionalization of the subsoil waters according to the suitableness degree for irrigation was performed in the Baku city and “A map of the schematic regionalization according to the suitableness degree of the subsoil waters the verdures irrigation in the Baku city” was compiled.
本文致力于分析巴库城区水文地质过程的形成条件,并评价底土对绿化灌溉的适宜性。经确定,底土水质适合该地区中部、东部和西部的绿化灌溉,但不适合该地区北部、东北部和西南部的局部地区。根据灌溉适宜度对巴库市底土进行了分区,并编制了“巴库市根据底土灌溉适宜度的示意性分区图”。
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引用次数: 0
Hyperparathyroidism in Pregnant Women: Clinical Issues, Laboratory Findings and Relevant Therapeutic Approachesr 孕妇甲状旁腺功能亢进:临床问题,实验室结果和相关治疗方法
Pub Date : 2021-04-16 DOI: 10.19080/arr.2021.06.555690
R. Fontes
Primary hyperparathyroidism (PHPT) is a disorder that results from hypersecretion of parathyroid hormone (PTH), which is the most common cause of hypercalcemia in the outpatient setting. An analysis published in 2013 showed that the incidence in women of reproductive age, within a racially mixed population, is 4.7-6.2 cases per 100,000 persons [1]. In pregnant women, the disease occurs in 0.5-1.4%, and in 80% it is due to adenoma of the parathyroid glands [2]. When untreated, PHPT can lead to maternal complications such as nephrolithiasis, pancreatitis, and eclampsia, and fetal complications such as low birth weight and neonatal seizure [3-6]. Adequate control of patients who become pregnant with hyperparathyroidism can be a challenge, depending on their clinical symptoms and the laboratory and imaging evaluation. According to the trimester of pregnancy and severity of the disease, the treatment may be either clinical or surgical. The authors present a case of a patient with a pre-pregnancy diagnosis, and a worsening of symptoms during pregnancy; she was referred for surgery due to failure of clinical treatment to keep the disease under control. Case Presentation
原发性甲状旁腺功能亢进(PHPT)是一种由甲状旁腺激素(PTH)分泌过多引起的疾病,这是门诊高钙血症的最常见原因。2013年发表的一项分析显示,在种族混合的人口中,育龄妇女的发病率为每10万人4.7-6.2例。在孕妇中,发病率为0.5-1.4%,80%是由甲状旁腺腺瘤引起的。如果不及时治疗,PHPT可导致产妇并发症,如肾结石、胰腺炎和子痫,以及胎儿并发症,如低出生体重和新生儿癫痫[3-6]。充分控制孕妇甲状旁腺功能亢进症可能是一个挑战,取决于他们的临床症状和实验室和影像学评价。根据妊娠的三个月和疾病的严重程度,治疗可以是临床或手术。作者提出了一个病例的病人与孕前诊断,并在怀孕期间的症状恶化;由于临床治疗未能控制病情,她被转介手术。案例展示
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引用次数: 0
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