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The Legislature in Intra-Executive Crisis and Institutional Instability in Nigeria 尼日利亚行政内部危机和机构不稳定中的立法机构
Pub Date : 2018-10-09 DOI: 10.19080/arr.2018.03.555623
Ibraheem Oladipo Muhee
The preeminence of legitimate institutional preferences distinguishes popular government from dictatorship. The imperative for viable legislative institutions to the consolidation of popular government in Nigeria cannot be overemphasized. This study interrogates legislatures’ complicity in intra-executive conflicts, deputy-governorship turnover, and institutional instability, with a view to mitigate further undermining of the institution of the legislature. Qualitative method, descriptive analysis, theories of separation of powers, institutionalization, and the prebendal conception of the Nigeria state, its post-colonial and post-conflict transactional politics suffice. The 1999 Constitution features bicameral national, and unicameral subnational assemblies and multi-level executives. It enjoins separation of powers with delineation of the functional boundaries of governmental institutions vis-à-vis the rule of law to guard against encroachment and impunity. Sections 176 and 186 provide for Governor, and Deputy-Governor, common to all the thirty-six States. Sections 130 and 141 provide for President and Vice-President respectively. Deputy-Governor is significant, as next to, and prospective Governor. Governorship candidates pick running mate for election and voters express support for the duo correspondingly. However, the ‘potential advantage is often counteracted by the prevalence of crisis-ridden executives’, exacerbate by compromised legislatures. Subnational legislative-executive relationship was characterized by the manipulation of legislatures by Governors to personal political ends. Cases abound of intra-executive crisis of confidence that thwarted collective executive successes while leaving both institutions deeply divided amidst accusations, counter-accusations and indictments. A survey of these cases reveals extensive legislatures’ complicity in summary impeachment, forced resignation and intimidation of many Deputy-Governors on sundry allegations leading to high Deputy-Governorship turnover. Pliable legislatures became executives’ whipping tools at the disposal of Governors to whip uncooperative and recalcitrant deputies into line, within days in blatant subversion of the Constitution. Judicial reviews invalidating identified undue legislative interferences underscore vexed question on legislatures’ autonomy, internal complexity and universalism, making mockery of constitutional government.
合法制度偏好的显著性将民众政府与独裁政府区分开来。建立可行的立法机构以巩固尼日利亚人民政府的必要性再怎么强调也不为过。本研究探讨了立法机构在行政内部冲突、副州长更替和机构不稳定中的共谋,以期减轻立法机构的进一步破坏。定性方法、描述性分析、三权分立理论、制度化、尼日利亚国家的预先概念、其后殖民和后冲突交易政治就足够了。1999年的宪法规定了两院制的国家议会和一院制的地方议会以及多层次的行政机构。它要求权力分立,划定政府机构的职能界限,以-à-vis法治防止侵犯和有罪不罚。第176条和第186条规定了36个州共有的州长和副州长。第130条和第141条分别规定主席和副主席的职务。副州长是重要的,仅次于未来的州长。州长候选人选择竞选伙伴,选民相应地支持两人。然而,“潜在的优势往往被危机重重的高管们所抵消”,而妥协的立法机构又加剧了这种优势。地方立法机关-行政机关关系的特点是州长为了个人政治目的而操纵立法机关。管理层内部的信任危机阻碍了管理层的集体成功,同时使两家机构在指责、反指控和起诉中严重分裂,这样的案例比比皆是。对这些案件的一项调查显示,许多副州长因各种指控被草率弹劾、被迫辞职和恐吓,导致副州长更替率很高,许多立法机构都参与其中。柔韧的立法机构变成了行政人员的鞭子工具,任凭州长们摆布,在几天之内就把不合作和不听话的议员们鞭打得就范,这是对宪法的公然颠覆。司法审查认定的不当立法干预无效,凸显了立法机构的自主性、内部复杂性和普遍性等棘手问题,是对宪政的嘲弄。
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引用次数: 0
Preparation, Characterization, and In Vitro Evaluation of Cream & Gel Formulations Containing Lidocaine and Tetracaine 含有利多卡因和丁卡因的乳膏和凝胶制剂的制备、表征和体外评价
Pub Date : 2018-10-09 DOI: 10.19080/arr.2018.03.555621
T. Comoglu
There are multiple different topical anesthetic options available to minimize the pain associated with cosmetic dermatologic procedures. These options are used either alone or in combination and the most used dermal analgesics are lidocaine, tetracaine, prilocaine, or their combinations. EMLA® cream is a local anesthetic that contains lidocaine and prilocaine combination and can be applied to the skin to help suppressing the pain of needle procedures, but it requires occlusion and the length of time for the medication to stay on the skin depends on the type of procedure. It is usually applied at least 1-2 hours before minor skin procedures. The object of this study was to develop topical cream and gel formulations of lidocaine-tetracaine (LT) combination with a suitable consistency to maintain an effective pain alleviation with a faster onset of action which may be an alternative to EMLA® in superficial operations. Two different formulations of LT; a water-in-oil (w/o) emulsion and an emul gel thickened with Carbomer 974 were manufactured. pH levels of emulgel formulations were ranged between 7.2-7.7 at t 0 , and 8.2-8.9 at t 30 , respectively. The w/o cream and emulgel formulations showed shear thinning thixotropic behavior at t 0 and t 30 . The morphological properties have been analyzed with a texture analyzer, and properties such as hardness, cohesiveness, and elasticity were calculated. The yield percentage of lidocaine was 65-100%, and tetracaine was 45-100% in emulgels, and 39-79% and 47-67% in creams. In vitro studies showed that LT release was faster in emulgel formulations, and tetracaine release had a longer duration in all formulations. In conclusion, cream and emulgel formulations of LT combination with a suitable consistency, pH level and longer duration of action have been manufactured and evaluated by means of in vitro tests.
有多种不同的局部麻醉剂可供选择,以最大限度地减少与美容皮肤科手术相关的疼痛。这些选择可以单独使用或联合使用,最常用的皮肤止痛药是利多卡因、丁卡因、丙胺卡因或它们的组合。EMLA®乳膏是一种含有利多卡因和丙胺卡因组合的局部麻醉剂,可用于皮肤以帮助抑制针头手术的疼痛,但它需要闭塞,药物在皮肤上停留的时间长短取决于手术类型。它通常在小的皮肤手术前至少应用1-2小时。本研究的目的是开发具有适当稠度的利多卡因丁卡因(LT)组合的局部乳膏和凝胶制剂,以保持有效的疼痛缓解和更快的起效,这可能是EMLA®在浅表手术中的替代方案。LT的两种不同配方;制备油包水(w/o)乳液和用卡波姆974增稠的乳液凝胶。乳化凝胶制剂的pH水平在t0时分别在7.2-7.7和t30时分别在8.2-8.9之间。w/o乳膏和乳胶凝胶制剂在t0和t30时表现出剪切稀化触变行为。用纹理分析仪分析了其形态特性,并计算了硬度、内聚性和弹性等特性。利多卡因的产率为65-100%,丁卡因在乳液中的产率为45-100%,在乳膏中的产率分别为39-79%和47-67%。体外研究表明,乳胶凝胶制剂中LT的释放更快,而丁卡因在所有制剂中的释放持续时间更长。总之,已经生产出具有合适稠度、pH水平和较长作用时间的LT组合乳膏和乳化凝胶制剂,并通过体外试验进行了评估。
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引用次数: 1
Importance of Development Initiative Ownership by the Benefiting Community: The case of Community-Based Production and Marketing Systems 受益社区拥有发展主动权的重要性:以社区为基础的生产和营销系统为例
Pub Date : 2018-10-09 DOI: 10.19080/arr.2018.03.555622
Kavoi J
This case study used a Private Public Partnership on a Gadam sorghum development initiative with a view to understanding the conceptualization, implementation, outputs, outcomes and lessons for policy, practice and research. The development initiative involved several stakeholders, namely, East African Breweries, Researchers, Ministry of Agriculture, Equity bank, Smart Logistics and Provincial administration, Ministry of culture and Social Services, and farmer producer groups. Research and development agencies introduced several organizational and technical innovations including production clusters, improved sorghum, payment using warehouse receipts and others. The farmers brought in various technical innovations, which included bird diversion strategies, bird avoidance strategy, planting along plough furrows and many sorghum recipes. The diverse recipes led to a change of perception towards this high value traditional crop and thus the grain became a source of food for the farmers. Payment through the bank helped the farmers to access finances easily and other banks started similar initiatives in the area. It was observed that a technology without appropriate configuration of partners will not create the desired impact. Communication between partners is important towards sustaining the innovation process and a feedback capture and incorporation tool into research is necessary. It was also apparent that support to the whole value chain is important rather than focusing on the output end of the chain. There is therefore need for policies to balance between the profit needs of the entrepreneur and the income/food needs of the farmers. It is important for producers to own such initiatives in order to build sustainability of the innovation process beyond the expiry of external agency intervention initiatives. There is also need to encourage formation of structures representing farmers to negotiate fair contracts with partners or to provide technical advice or credit to their members.
本案例研究使用了Gadam高粱开发倡议的公私伙伴关系,以了解政策、实践和研究的概念化、实施、产出、结果和经验教训。该发展倡议涉及几个利益攸关方,即东非酿酒厂、研究人员、农业部、股权银行、智能物流和省级行政部门、文化和社会服务部以及农民生产商团体。研发机构引入了一些组织和技术创新,包括生产集群、改良高粱、使用仓单付款等。农民们带来了各种技术创新,包括鸟类转移策略、鸟类回避策略、犁沟种植和许多高粱配方。多样化的食谱改变了人们对这种高价值传统作物的看法,因此谷物成为农民的食物来源。通过银行付款帮助农民轻松获得资金,其他银行也在该地区启动了类似的举措。据观察,一项技术如果没有适当的合作伙伴配置,就不会产生预期的影响。合作伙伴之间的沟通对于维持创新过程非常重要,有必要将反馈捕获和纳入研究。同样显而易见的是,对整个价值链的支持很重要,而不是关注链的输出端。因此,需要制定政策,在企业家的利润需求和农民的收入/粮食需求之间取得平衡。重要的是,生产者要拥有这些举措,以便在外部机构干预举措到期后建立创新过程的可持续性。还需要鼓励建立代表农民的结构,与合作伙伴谈判公平的合同,或向其成员提供技术咨询或信贷。
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引用次数: 0
Narrowing Gaps from Global Trends to National Contexts, How Clinical Guidelines Operating 缩小从全球趋势到国家背景的差距,临床指南如何运作
Pub Date : 2018-10-09 DOI: 10.19080/arr.2018.03.555624
H. Hussain
Evidenced-based and national context orientated Guidelines help clinicians translate best evidence into best practice. A wellcalipered guideline improves quality by reducing variations in healthcare delivery. Clinical Guidelines remarkably contributing to Improving diagnostic accuracy, enhancing effective therapy, and restricting ineffective or potentially non-effective interventions. Clinical guidelines methodology seems to be poorly defined and clearly varies at different organizations. One of the gaps needs to be closed under national clinical guidelines is to generate and develop a quality-driven, evidence-based through utilizing an efficient and rigors methodology for action and setting up ready recommendations with multi-disciplinary applicability. The Process of development, that permit moving from conception to completion in a well-defined period of time, always emphasizes a logical sequence of key action statements supported by amplifying text, evidence profiles, as well as a recommendation which link action to evidence [1].
循证指南和国家背景导向指南帮助临床医生将最佳证据转化为最佳实践。精心编制的指南通过减少医疗保健服务的变化来提高质量。临床指南显著有助于提高诊断准确性,加强有效治疗,限制无效或潜在无效的干预措施。临床指南的方法似乎定义不清,而且在不同的组织中明显不同。根据国家临床指南,需要缩小的差距之一是,通过利用有效和严格的行动方法,并制定具有多学科适用性的现成建议,产生和发展一种以质量为导向、以证据为基础的方法。开发过程允许在明确规定的时间内从构想到完成,它总是强调关键行动陈述的逻辑顺序,并由放大文本、证据概要以及将行动与证据联系起来的建议来支持。
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引用次数: 0
Experience Outside of Clinical Trial with Everolimus 依维莫司临床试验之外的经验
Pub Date : 2018-10-09 DOI: 10.19080/arr.2018.03.555625
Beatriz Losada Vila
100% of the patients are <65 years old (1 premenopausal, on treatment with gnRH analogue), with an ECOG 0-1 in 100%. 40% started as a metastatic disease. Disease-free interval was greater than 2 years in 100% of the patients.20% present 3 or more metastatic locations, while the remaining 80% present between 1-2 locations. 100% have visceral involvement. The indication of everolimus in the 5 patients was as much in 1st line as in 2nd, 3rd, 4th and 5th line. The patient who received everolimus in the first line was due to progression to aromatase inhibitor during the adjuvant setting. Regarding the treatments previously received, 60% were treated with fulvestrant, while also 60% had previously received chemotherapy for metastatic disease. 80% were on exemestane in combination with everolimus, while 20% combined it with letrozole. The starting dose of everolimus was 10 mg in all patients. The median time on everolimus was 7.5 months (2-14), presenting in 60% (3/5) toxicity, being 2/3 in the first 15 days and 1/3 in the following 15-30 days. A patient continues with everolimus at present. The most frequently reported toxicity is as mucositis in 60% (2/3 grade 3, 1/3 degree 2) that requires dose delay in all of them and dose reduction to 5 mg in 2/3. The second most frequent toxicity was pneumonitis (2/5 = 40% grade 1 and 2 respectively). All patients received mouthwash with dexamethasone prior to the onset of everolimus. As a hematological toxicity, only grade 1 plaquetopenia stands out in 20%. The maximum response was in the form of stability in 3/5 (60%), no partial or complete reduction, while progression was in 2/5 (40%) at the first reevaluation test [1,2].
100%的患者年龄<65岁(1例绝经前,接受gnRH类似物治疗),100%的ECOG为0-1。40%是从转移性疾病开始的。100%的患者无病间隔大于2年。20%存在3个或更多的转移部位,而其余80%存在1-2个转移部位。100%是内脏受累。依维莫司在5例患者中的适应症1线与2、3、4、5线相同。在一线接受依维莫司的患者是由于在辅助治疗期间进展为芳香化酶抑制剂。对于先前接受的治疗,60%的患者接受过氟维司汀治疗,而60%的患者先前接受过转移性疾病的化疗。依西美坦联合依维莫司占80%,来曲唑占20%。所有患者依维莫司起始剂量均为10mg。依维莫司治疗的中位时间为7.5个月(2-14),毒性为60%(3/5),前15天毒性为2/3,后15-30天毒性为1/3。1例患者目前继续使用依维莫司。最常见的毒性报告是60%(2/3级3,1 /3度2)的粘膜炎,所有这些都需要延迟剂量,2/3的剂量减少到5mg。第二常见的毒性是肺炎(2/5 = 40%,分别为1级和2级)。所有患者在使用依维莫司前均使用地塞米松漱口水。作为血液学毒性,只有1级血小板减少症占20%。在第一次再评估测试中,最大反应为3/5的稳定性(60%),没有部分或完全复位,而进展为2/5(40%)[1,2]。
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引用次数: 0
Equine theileriosis: Review Equine Telleriosis:综述
Pub Date : 2018-09-28 DOI: 10.19080/arr.2018.03.555620
F. L. Leivas Leite
Equine theileriosis, caused by the Apicomplexa protozoan Theileria equi , is an intra-erythrocytic parasite disease found in horses, and it is widely distributed throughout the world. Its prevalence and endemicity are linked to the presence of tick vectors and chronic equine carriers. Diagnosis of theileriosis is based on serological methods, including ELISA (Enzyme-Linked Immunosorbent Assay), IFAT (indirect fluorescent antibody), and molecular methods such as PCR (Polymerase Chain Reaction). Theileria has merozoite proteins, (EMA-1, EMA-2, EMA-3 and EMA-6). These antigens play an important role in pathogenesis and provide as host immune response targets against the parasite. EMA-1 and EMA-2 have been identified as immunodominant antigens and they are expressed on the surface of extra-erythrocyte merozoites. EMA-1 protein has been used in commercial testing of immunodiagnostic; however, EMA-2 is a highly conserved immunogenic protein and a promising target. The aim of this study is to contribute to improving the diagnosis and prevention of equine theileriosis.
马泰勒氏病是一种在马身上发现的红细胞内寄生虫病,由Apicomplex原生动物马泰勒氏引起,在世界各地广泛分布。其流行率和地方性与蜱媒和慢性马携带者的存在有关。泰氏菌病的诊断基于血清学方法,包括ELISA(酶联免疫吸附法)、IFAT(间接荧光抗体)和PCR(聚合酶链式反应)等分子方法。泰勒虫具有裂殖子蛋白(EMA-1、EMA-2、EMA-3和EMA-6)。这些抗原在发病机制中起着重要作用,并作为宿主针对寄生虫的免疫反应靶点。EMA-1和EMA-2已被鉴定为免疫显性抗原,它们在红细胞外裂殖子表面表达。EMA-1蛋白已被用于免疫诊断的商业测试;然而,EMA-2是一种高度保守的免疫原性蛋白,也是一种有前景的靶点。本研究的目的是为了提高对马的诊断和预防。
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引用次数: 0
Incidence of Malaria in Khyber Pakhtunkhwa Pakistan - A Meta-Analysis 巴基斯坦开伯尔-普赫图赫瓦省疟疾发病率的Meta分析
Pub Date : 2018-09-24 DOI: 10.19080/arr.2018.03.555619
Najeeb Ullah Khan
Background: Malaria is a fatal disease normally transmitted through the bite of an infected Anopheles mosquito. It is usually found in tropical and subtropical climates where the parasites responsible for causing the disease live. Five types of malaria parasites infect humans: Plasmodium (P) falciparum, P . vivax, P . ovale, P . malariae and P . knowlesi. P. vivax and P . falciparum are present in Khyber Pakhtunkhwa province of Pakistan, but no actual prevalence data is yet recorded. This study was commenced to precisely estimate the prevalence rate of Malaria across the province through a review of papers reporting prevalence data in the region. Methods: The essential target of this efficient survey and meta-analysis was to describe the detailed clinical quality and the geographical variety of the prevalence of severe malaria, found in literature search from the databases, since 2003 to 2017. Abstracts and results of twenty-one papers were considered and the information was extracted, based on prevalence rate of malaria in general and local population. Results: Out of the 21 studies chosen, on the basis of inclusive criteria, 18 studies were finally selected for further analysis. The combined estimate from the random effect model gave 13.81% prevalence. The prevalence of malaria sharply increased from 2013 onwards compared to the previous years. Highly significant (p-value < 0.0001) heterogeneity is observed among the studies. Further it is found that study no. 16, and 9 out of those included possess maximum contribution to the heterogeneity and are highly influential. The corresponding funnel plot reveals significant considerable asymmetry and publication bias. Conclusion: Despite of malaria control program in recent years, the incidence of malaria is still in alarming situation at KP-Pakistan. Further analysis based on general population screening will be required to figure out the actual situation of malaria at KP-Pakistan.
背景:疟疾是一种致命的疾病,通常通过受感染的按蚊叮咬传播。它通常在热带和亚热带气候中发现,导致这种疾病的寄生虫生活在那里。五种类型的疟原虫感染人类:恶性疟原虫,P。间日,P。椭圆,P。malariae和P。knowlesi。间日疟原虫和P。巴基斯坦开伯尔-普赫图赫瓦省存在恶性疟原虫,但尚未记录到实际流行率数据。这项研究是为了通过审查报告该地区疟疾流行率数据的论文,准确估计该省的疟疾流行率。方法:这项有效调查和荟萃分析的主要目标是描述自2003年至2017年以来,在数据库的文献搜索中发现的严重疟疾流行的详细临床质量和地理多样性。考虑了21篇论文的摘要和结果,并根据普通人群和当地人口的疟疾流行率提取了信息。结果:在选择的21项研究中,根据包容性标准,最终选择了18项研究进行进一步分析。根据随机效应模型的综合估计,患病率为13.81%。与前几年相比,从2013年起,疟疾流行率急剧上升。在研究中观察到高度显著(p值<0.0001)的异质性。此外,研究发现,第16项和第9项研究对异质性的贡献最大,影响很大。相应的漏斗图显示出显著的非对称性和发表偏倚。结论:尽管近年来实施了疟疾防治计划,但巴基斯坦KP的疟疾发病率仍处于令人担忧的境地。需要在一般人口筛查的基础上进行进一步分析,以了解巴基斯坦KP的疟疾实际情况。
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引用次数: 5
Hyperhidrosis and its Prevalence in a Population: A Cross Sectional Survey 多汗症及其在人群中的患病率:一项横断面调查
Pub Date : 2018-09-24 DOI: 10.19080/arr.2018.03.555617
Mubashar Mashqoor Mir
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引用次数: 0
Quality of Vermicompost Prepared from Bombax Ceiba Flowers in Presence of Different Quantities of Cow Dung with or without Nutrient Additives 添加或不添加营养添加剂的牛粪对蚕豆花蚯蚓堆肥质量的影响
Pub Date : 2018-09-24 DOI: 10.19080/arr.2018.03.555618
Sannigrahi Ak
Huge quantity of Bombax ceiba flowers remains unutilized for beneficial purpose and burnt as wastes by villagers. The vermicomposting experiment showed that good quality nutrient rich vermicompost having 1.13% N, 0.48% P, 2.68% K, 0.55% Ca, 0.69% S and 2.29% Na could be prepared within 57 days from a mixture of equal quantity of flower and cow dung with the help of Eisenia fetida earthworms. Vermicomposting of this flower was also possible with addition of one fourth or even no cow dung. Flower cow dung ratio, however, played a significant role in effective vermicomposting of Bombax ceiba flowers. Application of nutrient additives like 0.5% urea, 0.5% rock phosphate and 2.5% Mahua seed cake during initial preparation of compost beds helped to improve nutrient status of vermicompost. Vermicomposting being easy and low-cost procedure should be followed by villagers for beneficial utilization of these beautiful flowers.
大量的木棉花仍然没有被用于有益的目的,并被村民当作废物焚烧。蚯蚓堆肥试验表明,以等量的花粪和牛粪为原料,在爱胜蚯蚓的辅助下,可在57天内制备出氮1.13%、磷0.48%、钾2.68%、钙0.55%、硫0.69%和钠2.29%的优质营养丰富的蚯蚓堆肥。在添加四分之一甚至不添加牛粪的情况下,也可以对这种花进行蚯蚓堆肥。花牛粪比例在木棉花的有效蚯蚓堆肥中起着重要作用。在堆肥床的初始准备过程中,施用0.5%尿素、0.5%磷酸岩和2.5%马花籽饼等营养添加剂有助于改善蚯蚓堆肥的营养状况。村民们应该采用简单、低成本的Vermicompositing工艺,以便对这些美丽的花朵进行有益的利用。
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引用次数: 0
Banking Union Perspectives of Eurozone Peripheries: A Critical View 欧元区外围国家的银行业联盟观点:一个批判的观点
Pub Date : 2018-09-10 DOI: 10.19080/arr.2018.03.555616
Dimitrios G Tsoutsas
This paper studies the perspectives of the Eurozone becoming a banking union apart from a monetary one. Risk- and debt-sharing of the financial sector between Eurozone member peripheries are under scrutiny and moral hazard incentives from the side of banking institutions are analyzed. While looking into advantages and drawbacks of debt mutualization, the beneficial character of a strongly-linked banking union is discussed, but also the rigorous constraints it has to overcome. JEL
本文研究了欧元区从货币联盟向银行联盟转变的前景。对欧元区外围成员国之间金融部门的风险和债务分担进行了审查,并分析了银行机构方面的道德风险激励。在分析债务共同化的利弊的同时,讨论了一个紧密联系的银行联盟的有利特征,以及它必须克服的严格约束。冻胶
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引用次数: 0
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Annals of reviews and research
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