Bulletin de la Societe de pathologie exotique最新文献

This is a descriptive cross-sectional unicentric study, with a prospective collection of data on the frequency of chronic complications of sickle cell disease in patients monitored at Souro Sanou University Hospital in Bobo-Dioulasso in the department of medicine conducted from April 1, 2017 to July 31, 2018. Patients with confirmed adult sickle cell disease, at least 16 years of age, who had given oral consent, was seen at least twice in the inter-critical period during the study, and who had performed a biological and / or radiological screening for chronic complications. Out of 144 sickle cell patients seen, 79 met our inclusion criteria. The mean age of the patients was 28.8 ± 10.3 years with extremes of 16 and 63 years. Females predominated in 68% of cases (N = 54). Sickle cells were of SC phenotype in 68% of cases, SS in 24%, Sβ + in 5% of cases and Sβ0 in 3% of cases. The overall prevalence of complications was 54% (43/79), 68% (13/19) in SS individuals and 50% in SC individuals (27/54). The observed chronic complications were ocular, bony, renal, cardiac, cutaneous respectively in 19%, 13%, 6.3%, 5% and 4% of cases, biliary and neurological in 3% each, ENT and pulmonary in 1.3% each. The mean age of patients with at least one chronic complication was 30.9 ± 10.4 years; it was 32.1 ± 10.3 years old in the SC and 25.3 ± 7.8 years old in the SS. Complications were unique in 72%, double in 23% and triple in 5%. The prevalence of chronic complications of sickle cell disease is high in patients with major sickle cell syndrome. Systematic screening and evaluation of organ damage are required to interrupt or delay their evolution.

The province of Equateur in the north-west of the Democratic Republic of the Congo (DRC) experienced a new Ebola outbreak in 2020. Among the responses, the actions of prevention and control of the infections were essential, particularly in health facilities. They need to be developed from a long-term perspective and not as a one-off emergency response.

Malaria remains a public health problem in Côte d'Ivoire despite a 95% coverage rate with long-lasting insecticide-treated mosquito nets (LLINs) since 2015. A study was conducted in Bouaké to determine the residual efficacy of LLINs used during 17 months (N = 30) and of stored and unpacked LLINs (N = 8). The physical integrity of LLINs and their biological efficacy on populations of Anopheles gambiae (sensitive and resistant to insecticides) were assessed. The study revealed that 57% (17/30) of LLINs recovered from households have a hole. The proportional hole indices indicated that 70% (21/30) of LLINs were in good condition, 20% (6/30) were repairable and 10% (3/30) were unusable.This study also showed that the LLINs used and stored were effective on the sensitive Kisumu strain but ineffective on resistant populations of An. gambiae of Bouaké. Average knock-down and mortality rates induced by LLINs used on the populations of An. gambiae from Bouaké were 23% and 9%, respectively. The resistance of mosquitoes to insecticides and the alteration of the physil integrity of mosquito nets are probably major factors to be taken into account in estimating the efficacy of LLINs in the field.

In thirty years, bed nets treated with pyrethroids have been established as a means of prevention against malaria for personal protection and in public health. One of the actors of these discoveries gives an overview of insecticidetreated bed nets (ITNs) and brings his testimony, more particularly on the circumstances and frames of mind which prevailed in the 1980's, a crucial decade for these breakthroughs which served humanity. In 1983, the first experiment testing the effect of bed nets treated with pyrethroid insecticide was performed and revealed the impact of this method on the reduction of Plasmodium transmission. This discovery was made in an experimental field station in Burkina Faso showing that each of the many entomological parameters measured led to a clear decrease in mosquito-human contact. A few years later, still in Burkina Faso, it was shown that ITNs, massively used in a village, reduced the longevity and vector capacity of mosquito populations, to such an extent that ITNs acted as a means of vector control. These researches were all led within the Centre Muraz of the Organization of Coordination and Cooperation for the Control of Great Endemies (OCCGE) by researchers belonging to the Office of Overseas Scientific and Technical Research (ORSTOM, which later became French National Research Institute for Sustainable Development), and benefited from the scientific and financial support of the Division of Vector Biology and Control from the World Health Organization (WHO).

Health research studies are increasingly focusing on digestive cancers because of their increasing frequency and severity. The objective of this work was to study the epidemiological aspects of primary digestive cancers in adults in three hospital centers in the commune of Cotonou. A total of 676 cases of digestive cancers were identified out of 25,093 patients received during the study period (2.7%). The mean age was 54 ± 14.1 years: [16-96] and the sex ratio was 2:1. The most frequent cancers were those of the liver (259; 38.3%) and colon-rectum (154; 22.8%). The next most common cancers in descending order were gastric cancer (12%), esophageal cancer (11.4%), pancreatic cancer (11.4%), anal cancer (1.9%), hail cancer (1.5%) and biliary cancer (0.7%). The average time to visit was 9 months. The main risk factors found were viral hepatitis B and C, alcoholism, diabetes, obesity, colonic polyps, smoking, excessive consumption of salt and dietary nitrates. Lethality was 58.4%, with cancers of the liver, colon-rectum, pancreas, and esophagus in descending order of mortality. The average overall survival was 10 months. Digestive cancers most often affect people in their fifties, who are usually men in Cotonou. They are dominated by liver cancer and colorectal cancer. Modifiable risk factors are often found. The control of these factors and early diagnosis could help improve the survival of patients affected.

If the acute and chronic osteo-articular complications of sickle cell anemia are well-known to the rheumatologist, certain forms including hand-foot syndrome are less so since they almost exclusively concern small children less than 4 years of age. We report here the observation of a hand-foot syndrome in a 36-year-old adult, homozygous sickle cell disease (SS), during a vaso-occlusive crisis, manifested by tenosynovitis of carpal extensors. After eliminating the other etiologies, notably infectious of palmar tenosynovitis, the vaso-occlusive origin will be confirmed by the rapidly favorable evolution of the clinical picture.

To improve the performance of Côte-d'Ivoire's immunization program, we have implemented a strategy to catch up with drop out children (DOC) and unvaccinated children (UVC) in 14 Health Districts (HDs) with the lowest measles vaccination coverage. This article presents the effectiveness and cost of this strategy. We selected the areas with the highest numbers of DOC: 5 health areas (HAs) per HD and 5 villages/neighborhoods per HA. The strategy, which was implemented by civil society organizations, health centre managers (HCMs) and community health workers (CHWs), combined sensitization of community leaders and groups, home visits (HV) and referral of children to the HCs for immunization. Out of the 17,912 reported DOC, 9,425 found (52.6%) and 8,245 were vaccinated (46% of declared, 87.5% of found). The HCMs reported 484 UVC while the home visits identified 1,315 of which 1,087 were vaccinated (82.7%). Out of a total declared number of 18,396 children to be caught up, 10,740 found (58.4%) and 9,332 vaccinated, i.e. 50.8% (9,332/18,396) of children to be caught up and 86.9% (9,332/10,740) of children found. The total specific recurrent cost of the strategy was XOF 22,375,008, with XOF 2,083 (22,375,008/10,740) per child found and XOF 2,398 (22,375,009/9,332) per child found and vaccinated. In view of these results, this strategy should be implemented in all of the country's low-performing HDs.

The article focuses on describing the different causal models of misfortune and their social constructions in the context of the Ebola virus disease which emerged in Equateur Province, Democratic Republic of Congo, in May 2018. Based on a corpus of qualitative data collected during three weeks of fieldwork, this article details the explanatory models relating to the chains of contamination and their hybridization between biomedical models and sorcery and/or political logic. By also addressing the impacts of discourse on the animal origin of the virus, this article contributes to an analysis of the gap between the different understandings and responses to the epidemic phenomenon and the scale of the response.

A retrospective research study was carried out by our team on Planorbarius metidjensis to highlight its epidemiological role as a potential host snail of Schistosoma haematobium in the Souss-Massa region. Contrary to the habitats colonized by Bulinus truncatus, the main host snail, those of P. metidjensis are located at the altitude of above 300 m. The best results of the experimental infections with S. haematobium were obtained using juvenile planorbids of 2 to 3 mm in diameter and a dose of five miracidia per snail. No snail naturally infected with the parasite was found when dissecting 3,457 adult bulinids and 2,470 adult planorbids. Despite the location of its habitats in altitude, P. metidjensis is a potential intermediate host of S. haematobium and it is important to follow these populations, as those of B. truncatus, in the future to avoid possible reoccurrence of indigenous cases of the disease.