Acta otorrinolaringologica espanola最新文献

英文中文

ENT pediatric infection diseases and its relationship with COVID-19. Results of a retrospective cohort study in Madrid, Spain 小儿耳鼻喉科感染及其与新冠肺炎的关系西班牙马德里一项回顾性队列研究的结果。

Acta otorrinolaringologica espanola

Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512225

Montserrat Asensi-Diaz, Monica Hernando Cuñado, Alex Lowy Benoliel, Juan Antonio Pasamontes Pingarron, Carlos Martin-Oviedo, Rosalia Souviron Encabo, Maria Scola Torres, Miguel Aristegui

Introduction

During the COVID-19 pandemic, ENT infections decreased but became more severe when combined with COVID-19. Post-pandemic, there has been a notable rise in ENT infections globally, particularly ear infections. In our region, we observed an increase in complicated pediatric ENT infections requiring urgent surgical intervention after the end of preventive measures. This study investigates the changes in ENT infection profiles in Madrid, Spain, following the pandemic.

Material and methods

We analyzed data from children who underwent urgent ENT surgical interventions at a Spanish tertiary hospital between January 2018 and December 2023. The data was divided into three groups: pre-pandemic (1st group), during the pandemic with preventive measures (2nd group), and post-pandemic after the removal of these measures (3rd group). Variables included demographics, clinical data, imaging, treatment, and hospitalization duration.

Results

The study involved 87 children (58.6% male) with a mean age of 6.4 years. There was a significant overall increase in ENT infections in the 3rd group compared to the 1st and 2nd groups (p = 0.036). Specifically, ear infections increased significantly after the removal of social measures (p = 0.033). In the 3rd group, Streptococcus pyogenes infections increased (p = 0.028), with Amoxicillin becoming the predominant treatment (p = 0.047), as opposed to Amoxicillin-clavulanic acid used for Fusobacterium in earlier periods (p = 0.00).

Discussion and conclusion

The pandemic has shifted the ENT infection profile, with increased ear infections and a rise in Group A streptococcus post-pandemic. This underscores the need for updated treatment strategies for pediatric ENT infections.

在2019冠状病毒病大流行期间，耳鼻喉科感染有所下降，但与COVID-19合并后变得更加严重。大流行后，全球耳鼻喉科感染，特别是耳部感染显著上升。在我们的地区，我们观察到在预防措施结束后需要紧急手术干预的复杂儿科耳鼻喉感染的增加。本研究调查了大流行后西班牙马德里耳鼻喉科感染概况的变化。材料和方法：我们分析了2018年1月至2023年12月在西班牙一家三级医院接受紧急耳鼻喉外科手术干预的儿童的数据。数据分为三组：大流行前（第1组）、大流行期间采取预防措施（第2组）和大流行后取消这些措施（第3组）。变量包括人口统计学、临床资料、影像学、治疗和住院时间。结果：共纳入87例儿童，其中男性58.6%，平均年龄6.4岁。与第1组和第2组相比，第3组耳鼻喉科感染的总体发生率显著增加（p = 0.036）。具体来说，移除社会措施后耳部感染明显增加（p = 0.033）。在第三组，化脓性链球菌感染增加（p = 0.028），阿莫西林成为主要的治疗方法（p = 0.047），而阿莫西林-克拉维酸在早期用于梭杆菌（p = 0.00）。讨论和结论：大流行改变了耳鼻喉科感染情况，耳部感染增加，大流行后a群链球菌增加。这强调了更新儿科耳鼻喉科感染治疗策略的必要性。

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引用次数: 0

“Cochlear Implant in a Labyrinthine Facial Nerve Dehiscence” “人工耳蜗治疗迷宫式面神经破裂”。

Acta otorrinolaringologica espanola

Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512226

Inés Tortajada Torralba , Santiago Almanzo , Carlos de Paula Vernetta

引用次数: 0

Epignathus: An unusual cause of airway obstruction in the newborn 表睑赘：新生儿气道阻塞的一种罕见病因。

Acta otorrinolaringologica espanola

Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512232

Monica Rueda Vega, Alex Lowy Benoliel, Rosalía Souvirón Encabo

引用次数: 0

Cross-cultural adaptation of the CRS-PRO questionnaire into Spanish CRS-PRO问卷在西班牙语中的跨文化改编。

Acta otorrinolaringologica espanola

Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512219

Juan Maza-Solano , Ainhoa García-Lliberós , Xenia Mota-Rojas , Andrea Barrios , Christian Calvo-Henríquez , Isam Alobid , Serafín Sánchez-Gómez , Leigh J Sowerby

Background

Chronic rhinosinusitis (CRS) is a prevalent disease responsible for significant morbidity. Diagnostic criteria are well established but response to clinical and surgical treatment need greater consistency. The objective of this paper was to perform a cross-cultural adaptation of the CRS-PRO to the Spanish language for its use as a routine questionnaire in the evaluation of CRS.

Methods

The CRS-PRO questionnaire was translated using a three-step procedure in 50 patients, following the recommendations of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Native speakers of both European and South American Spanish participated in the translation.

Results

Of the initial 12 items, 4 were discordant among the three translators before a consensus was reached (Step 1). The item “breathe through the nose” (1/12) did not match between the back translation and the initial version of the CRS-PRO (Step 2). Step 3 generated a final revised Spanish version of the CRS-PRO. Fifty patients (average age 51.1, 48% male) completed the questionnaire. Significant gender differences were found in responses to “My face hurt” (P = .043). Significant differences in “My face hurt” also appeared for those completing the questionnaire in less than 80 s (P = .047). Differences in “problems with smell” (P = .039) were noted between chronic rhinosinusitis with and without polyposis.

Conclusion

This study presents the validated and Spanish-adapted version of the CRS-PRO questionnaire to evaluate CRS symptoms in the Spanish-speaking population.

背景：慢性鼻窦炎（CRS）是一种发病率很高的常见病。诊断标准已经建立，但对临床和手术治疗的反应需要更大的一致性。本文的目的是对CRS- pro进行跨文化改编，使其成为评估CRS的常规问卷。方法：按照国际药物经济学与结果研究学会（ISPOR）的建议，采用三步程序对50例患者进行CRS-PRO问卷的翻译。以欧洲和南美西班牙语为母语的人都参与了翻译。结果：在最初的12个条目中，有4个条目在三个译者达成共识之前是不一致的（步骤1）。“通过鼻子呼吸”条目（1/12）在返回的翻译与CRS-PRO的初始版本之间不匹配（步骤2）。步骤3生成CRS-PRO的最终西班牙语修订版本。50例患者（平均年龄51.1岁，男性48%）完成问卷调查。在“我的脸受伤了”的回答中发现显著的性别差异（p = 0.043）。那些在80秒内完成问卷的人在“我的脸疼”方面也出现了显著差异（p = 0.047）。慢性鼻窦炎伴和不伴息肉病者在“嗅觉问题”方面存在差异（p = 0.039）。结论：本研究提出了经过验证的西班牙语版CRS- pro问卷，用于评估西班牙语人群的CRS症状。

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引用次数: 0

Improving voice quality in laryngectomy patients with botulinum toxin A 改善A型肉毒杆菌毒素喉切除术患者的语音质量。

Acta otorrinolaringologica espanola

Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512222

Gonçalo Caetano , Filipa Morgado , Joana Póvoa , Francisco Branquinho

Introduction

Tracheoesophageal (TEP) speech is the main voice rehabilitation method following laryngectomy. Pharyngoesophageal hypertonicity is one of the main causes for failure to achieve tracheoesophageal speech after laryngectomy. Botulinum toxin A (BTA) has been used to chemically denervate the pharyngeal musculature, and is an alternative to invasive surgical procedures. The aim of this work is to study the effectiveness and safety of this procedure.

Material & methods

A retrospective cohort study from 2019 to 2023 was performed of 20 patients with failure to achieve a functional tracheoesophageal voice following laryngectomy. These patients undergone local pharyngoesophageal segment BTA injection. A total of 100 units of BTA were injected at 6 different sites, 3 in each side.

Perceptual ratings of voice quality were performed before and 72 h after BTA injection by a speech therapist using a 7-point equal-appearing interval scale.

Results

Speech quality mean rating (μ) improved from 2.05 before to 4.55 after BTA injection (P = .004), 17 (85%) patients had an improvement in postinjection perceptual TEP speech quality ratings, with scores in the good-to-excellent range (5–6 in the 7-point equal-appearing interval scale) in 12 patients (60%).

Three patients (15%) didn’t improve their voice quality, two of them with no discernible TEP speech.

No adverse effects were reported.

Conclusions

The majority of the patients enrolled in this study (85%) showed an improvement in TEP speech following BTA injection. This is a safe and effective method to improve TEP speech following laryngectomy.

前言：气管食管（TEP）语音是喉切除术后主要的语音康复方法。咽食道高张力是喉切除术后气管食道言语不能实现的主要原因之一。肉毒毒素A （BTA）已被用于化学去神经咽肌肉组织，是一种替代侵入性手术程序。这项工作的目的是研究该程序的有效性和安全性。材料与方法：对2019年至2023年20例喉切除术后气管食管声带功能缺失患者进行回顾性队列研究。患者行咽食管段局部BTA注射。在6个不同部位注射100个单位BTA，每侧3个。在BTA注射前和注射后72小时，由语言治疗师使用7分均等间隔量表对语音质量进行感知评分。结果：语音质量平均评分（μ）由注射BTA前的2.05分提高到注射后的4.55分（p = 0.004）， 17例（85%）患者注射后感知TEP语音质量评分改善，12例（60%）患者评分为良好至优秀（7分等出现间隔量表5 ~ 6分）。3名患者（15%）的语音质量没有改善，其中2名患者没有明显的TEP语音。无不良反应报告。结论：本研究中大多数患者（85%）在注射BTA后TEP言语改善。这是一种安全有效的改善TEP术后言语的方法。

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引用次数: 0

The effect of interleukin-33 expression on prognosis in patients with nasopharyngeal carcinoma 白细胞介素-33的表达对鼻咽癌患者预后的影响

Acta otorrinolaringologica espanola

Pub Date : 2025-03-01 DOI: 10.1016/j.otoeng.2024.01.011

İbrahim Arslan , Hatice Yılmazçoban , Hülya Eyigör , Canan Sadullahoğlu , Derya Salim Kıvrak , Gözde Akgün , Ömer Tarık Selçuk

Introduction

Interleukin-33 (IL-33) is a newly defined inflammatory cytokine that is a member of the interleukin-1 (IL-1) gene family. This cytokine is expressed in structural cells, such as the vascular endothelium, bronchial epithelial cells, keratinocytes, epithelial cells of the stomach, and fibroblastic reticular cells of lymphoid tissues. Several studies suggest that IL-33 plays a role in head-and-neck cancer. The aim of this study was to retrospectively examine IL-33 expression in nasopharyngeal carcinoma (NPC) and to evaluate its relationship between clinicopathological characteristics and prognosis.

Methods

In this monocentric, retrospective analysis, the data of 43 cases diagnosed with primary NPC and 20 cases with normal nasopharyngeal tissue (diagnosed between 2014 and 2020) were evaluated regarding the relationship between the immunohistochemically analyzed IL-33 expression status and corresponding clinicopathological parameters.

Results

The mean age was 56.9 years. The majority (67.4%) of the patients had an early tumor stage (T1–T2). IL-33 expression was positive in 56% of the cases. The five-year overall survival rate was 77% for all patients, 90% for the patients with positive IL-33 expression, and 55% for those without IL-33 expression (p = 0.008, univariate analysis). In multivariate analysis, IL-33 expression was shown to be the only independent prognostic marker for nasopharyngeal carcinoma (p = 0.014).

Conclusion

This retrospective study showed that IL-33 expression could be considered an independent factor affecting positively prognosis in NPC.

简介白细胞介素-33（IL-33）是一种新定义的炎症细胞因子，是白细胞介素-1（IL-1）基因家族的成员。这种细胞因子在结构细胞中表达，如血管内皮细胞、支气管上皮细胞、角质形成细胞、胃上皮细胞和淋巴组织的成纤维网细胞。多项研究表明，IL-33 在头颈癌中发挥作用。本研究旨在回顾性检测鼻咽癌（NPC）中 IL-33 的表达，并评估其与临床病理特征和预后之间的关系：在这项单中心回顾性分析中，对43例确诊为原发性鼻咽癌的病例和20例正常鼻咽组织病例（确诊时间为2014年至2020年）的数据进行了评估，以了解免疫组化分析的IL-33表达状态与相应临床病理参数之间的关系：平均年龄为 56.9 岁。大多数患者（67.4%）处于肿瘤早期（T1-T2）。56%的病例 IL-33 表达阳性。所有患者的五年总生存率为 77%，IL-33 表达阳性患者的五年总生存率为 90%，无 IL-33 表达患者的五年总生存率为 55%（单变量分析，P = 0.008）。多变量分析显示，IL-33表达是鼻咽癌唯一独立的预后标志物（p = 0.014）：这项回顾性研究表明，IL-33的表达可被视为对鼻咽癌预后有积极影响的独立因素。

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引用次数: 0

Subcutaneous emphysema secondary to Eustachian tube dilation 继发于咽鼓管扩张的皮下气肿。

Acta otorrinolaringologica espanola

Pub Date : 2025-03-01 DOI: 10.1016/j.otoeng.2024.07.005

José M. Sala-Vivé Gallego , Laura Acevedo Ortiz , Xavier Galindo Ortegó

引用次数: 0

Otorhinolaryngological manifestations of autoinflammatory diseases. Systematic review 自身炎症性疾病的耳鼻喉科表现。系统回顾。

Acta otorrinolaringologica espanola

Pub Date : 2025-03-01 DOI: 10.1016/j.otoeng.2024.09.005

María Victoria Mallo-Miranda , Carmelo Morales-Angulo

Objectives

To detail the main otorhinolaryngological manifestations of autoinflammatory diseases, aiming to contribute to early diagnosis and treatment.

Data sources

Searches were conducted in PubMed, LILACS, Cochrane Library.

Review methods

A systematic review of the medical literature on autoinflammatory diseases was conducted to identify characteristic head and neck manifestations, using PRISMA criteria. Observational studies or systematic reviews with a minimum of 10 cases per disease were included. Qualitative synthesis and a risk assessment were carried out.

Results

Our review included 29 articles that met the inclusion criteria, with 10 to 486 patients per study. Autoinflammatory diseases with characteristic head and neck manifestations included VEXAS syndrome (auricular, nasal, or laryngotracheal chondritis), NPRL3-AID (hearing loss), NPRL12-AID (cervical lymphadenopathies, hearing loss and oral ulcers), HIDSs syndrome (painful cervical nodes and oral ulcers), haploinsufficiency A20 (oral ulcers), TRAPS (pharyngitis, aphthous stomatitis, periorbital edema, and cervical lymphadenopathies), Behcet’s disease (oral and pharyngeal ulcers), PFAPA syndrome (recurrent tonsillitis, oral ulcers, and painful cervical adenopathies), Kawasaki disease (cervical nodes, pharyngitis and changes in oral mucosa) and undefined periodic fever (pharyngitis, oral ulcers, and painful cervical nodes).

Conclusion

Given their complex diagnosis and unique head and neck manifestations, otolaryngologists must be well-versed in these diseases for early detection and treatment. ENT specialists should consider the possibility of an autoinflammatory disease when encountering symptoms such as auricular, nasal, or laryngeal chondritis, recurrent oral ulcers, painful inflammatory lymphadenopathies, periorbital edema, recurrent pharyngitis, or hearing loss within the context of compatible systemic conditions.

目的详细介绍自身炎症性疾病的主要耳鼻喉表现，旨在为早期诊断和治疗做出贡献：数据来源：在PubMed、LILACS和Cochrane图书馆进行检索：综述方法：采用 PRISMA 标准对有关自身炎症性疾病的医学文献进行了系统综述，以确定头颈部的特征性表现。每种疾病至少包含 10 个病例的观察性研究或系统性综述均被纳入其中。我们还进行了定性综合和风险评估：我们的综述共纳入了 29 篇符合纳入标准的文章，每项研究涉及 10 至 486 名患者。白塞氏病（口腔和咽部溃疡）、PFAPA 综合征（反复扁桃体炎、口腔溃疡和颈部疼痛性腺病）、川崎病（颈部结节、咽炎和口腔黏膜病变）和未定义的周期性发热（咽炎、口腔溃疡和颈部结节疼痛）。结论：鉴于其复杂的诊断和独特的头颈部表现，耳鼻喉科医生必须精通这些疾病，以便及早发现和治疗。耳鼻喉科专家在遇到耳、鼻或喉软骨炎、复发性口腔溃疡、疼痛性炎症性淋巴结病、眶周水肿、复发性咽炎或听力下降等症状时，应考虑到自身炎症性疾病的可能性，并结合相匹配的全身性疾病。

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引用次数: 0

Bell's palsy and COVID-19: A cohort study with historical rate comparison: Comment 贝尔麻痹和COVID-19：一项具有历史发病率比较的队列研究：评论。

Acta otorrinolaringologica espanola

Pub Date : 2025-03-01 DOI: 10.1016/j.otoeng.2024.11.001

Hinpetch Daungsupawong , Viroj Wiwanitkit

引用次数: 0

Evaluation of remote programming of cochlear implants under challenging conditions 挑战性条件下人工耳蜗远程编程的评价。

Acta otorrinolaringologica espanola

Pub Date : 2025-03-01 DOI: 10.1016/j.otoeng.2025.02.002

Luis Lassaletta , Miryam Calvino , Isabel Sánchez-Cuadrado , Giovanni Danesi , Ilaria Patelli , Michela Zana , Íñigo Ruiz de Erenchun-Lasa , Manuela del Carmen Zapata , Eva María Muñoz Yuste , Daniel Schaudel , Cherisse Mark , Gionata Conni , Pedro Luis Sarría Echegaray , Guillermo til-Pérez , Isaac David Gutiérrez Pérez , Elena Muñoz Pascual

Introduction and objectives

During the strained period of the COVID-19 pandemic, an international multi-centric clinical pilot study of remote cochlear implant fitting (remote programming) took place with the primary aim of evaluating the satisfaction of patients and practitioners with this procedure.

Materials and methods

Cochlear implant users and clinical practitioners from clinics in Spain and Italy completed a questionnaire to evaluate their experience regarding their satisfaction with the procedure and with its efficacy.

Results

54 responses were collected from 48 users and 42 responses were collected from 9 clinical practitioners. Practitioners were able to perform both remote fitting and remote telemetry. They rated their satisfaction with the procedure highly, with a median value of 9.5/10. Over 90% were satisfied with the results of the procedure, and all who responded would be willing to use remote programming again. Practitioners also rated the technical performance highly. Users rated their satisfaction with the procedure with a median value of 8/10. The great majority of users would be willing to undergo remote programming again (81.3%), and most would recommend the procedure to other users (74%).

Conclusions

Remote programming is a well-received procedure among both clinical practitioners and cochlear implant users, and offers a useful alternative when in-person visits are not practical or not possible, as was the case during the pandemic.

简介和目的：在新冠肺炎大流行的紧张时期，开展了一项远程人工耳蜗植入（远程编程）的国际多中心临床试点研究，主要目的是评估患者和医生对该手术的满意度。材料和方法：来自西班牙和意大利诊所的人工耳蜗使用者和临床从业人员完成了一份调查问卷，以评估他们对手术及其疗效的满意度。结果：从48名用户中收集了54份回复，从9名临床医生中收集了42份回复。从业人员能够进行远程装配和远程遥测。他们对手术的满意度评价很高，中位数为9.5/10。超过90%的人对程序的结果感到满意，所有回应的人都愿意再次使用远程编程。从业人员也高度评价了技术性能。用户对手术的满意度中位数为8/10。绝大多数用户愿意再次进行远程编程（81.3%），大多数用户会向其他用户推荐该程序（74%）。结论：远程编程在临床从业人员和人工耳蜗使用者中都是一种广受欢迎的程序，并且在不实际或不可能亲自访问时提供了一种有用的替代方案，例如在大流行期间。

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