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Acanthamoeba keratitis in the last decade. What have we learned? 过去十年中的阿卡阿米巴角膜炎。我们学到了什么?
Pub Date : 2024-11-18 DOI: 10.1016/j.oftale.2024.11.001
A Arnaiz-Camacho, L Goterris Bonet, L Bisbe Lopez, S Martín Nalda, J Puig Galy, S García-Hidalgo, Tatiana Pablos-Jiménez, A Pairó-Salvador

Introduction: Acanthamoeba keratitis continues to be one of the most feared corneal infections due to its severity and capacity to generate irreversible visual sequelae. Despite diagnostic and therapeutic advances, this disease is increasing in our environment every year, related to a growing number of contact lens users. This last decade marked by the COVID-19 pandemic represents an unprecedented historical scenario whose impact must be analyzed from different health points of view. This study aims to describe the epidemiology, clinical presentation, treatment and evolution of Acanthamoeba keratitis in a tertiary hospital in the last 10 years.

Results: The results have been obtained from a total of 13 eyes of 13 patients. This series of cases shows a diagnostic gap during the pandemic period, with a greater number of patients in the previous and post-pandemic stages. The different parameters of clinical presentation, microbiological diagnosis and clinical evolution are analyzed. All patients in our study wore contact lenses. Five of the cases were initially diagnosed in other centers as herpetic keratitis. Seven patients had a pseudo-dendrite as initial presentation, while six cases presented as an annular infiltrate. In all cases, 0.02% chlorhexidine eye drops were prescribed and this was associated with 0.1% propamidine in 11 cases. The results were variable, achieving an improvement in visual acuity in 10 of the cases.

Conclusion: This is a study on an emerging disease and with increasingly advanced knowledge and use of diagnostic and therapeutic tools in the historical context of a pandemic. This text attempts to shed light on the different forms of presentation and management of cases of Acanthamoeba keratitis.

导言:阿卡阿米巴角膜炎因其严重性和产生不可逆视力后遗症的能力,仍然是最令人恐惧的角膜感染之一。尽管在诊断和治疗方面取得了进步,但这种疾病在我们的环境中每年都在增加,这与越来越多的隐形眼镜使用者有关。在过去的十年中,COVID-19 的流行代表了前所未有的历史场景,必须从不同的健康角度分析其影响。本研究旨在描述一家三级医院在过去 10 年中阿卡阿米巴角膜炎的流行病学、临床表现、治疗和演变情况:结果:共对 13 名患者的 13 只眼睛进行了检查。这一系列病例表明,在大流行期间存在诊断上的差距,而在大流行之前和之后阶段的患者人数较多。研究分析了临床表现、微生物诊断和临床演变的不同参数。我们研究的所有患者都佩戴隐形眼镜。其中五例最初在其他中心被诊断为疱疹性角膜炎。七名患者最初表现为假性树枝状角膜炎,六名患者表现为环状浸润。在所有病例中,都使用了 0.02% 洗必泰滴眼液,在 11 个病例中使用了 0.1% 丙脒滴眼液。结果不一,其中 10 例的视力有所改善:这是一项关于新兴疾病的研究,在大流行病的历史背景下,诊断和治疗工具的知识和使用日益先进。本文试图阐明阿卡阿米巴角膜炎病例的不同表现形式和治疗方法。
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引用次数: 0
Ciliary body melanoma: multimodal composition 睫状体黑色素瘤:多模式组合。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.002
B. Alamar Pérez, J. Montero Hernández, E. Cervera Taulet
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引用次数: 0
Post-traumatic retinal siderosis, a case report 创伤后视网膜巩膜病变,病例报告。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.011
A. Ortiz , M. Garcés , J. Toala , E. Vazquez , J. Ortiz
A thirty-year-old patient attended a few hours after an ocular trauma while hammering, receiving trauma with a metal splinter at the left eye. Due to an unfavorable clinical picture, surgical management was decided, which was initially rejected by the patient. He returned six months later with a profound decrease in left eye visual acuity, reaching counting finger at one meter despite optical correction. The anterior segment shows a lower scarring leukoma, associated with Tyndall (++), retrokeratic pigment, lower posterior synechiae and a total cataract. Cataract surgery with intraocular lens implantation and a posterior vitrectomy with intraocular foreign body extraction were indicated. At postoperative control it was shown that post-traumatic ocular siderosis did not significantly affect his central vision, which remains until now.
一名 30 岁的患者在锤击时眼部受创几小时后就诊,左眼被金属碎片刺伤。由于临床表现不佳,医生决定进行手术治疗,但患者起初拒绝接受。6 个月后,他再次就诊,左眼视力严重下降,尽管进行了光学矫正,但仍只能在 1 米处数手指。前段显示下部瘢痕性白血病,伴有 Tyndall(+++)、角膜后色素沉着、下后裂和全白内障。白内障手术需要植入眼内晶状体,后玻璃体切除术需要取出眼内异物。术后检查显示,外伤后眼球巩膜病变并没有对他的中心视力造成明显影响,这种情况一直持续到现在。
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引用次数: 0
Female ophthalmologists’ perception of occupational hazards during pregnancy 女眼科医生对孕期职业危害的看法。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.001
Y. Cifre Fabra , I. Gil Hernández , R. Martínez Belda , A. Duch Samper

Objective

Woman ophthalmologists of childbearing age are exposed to different types of occupational risks which can be harmful to pregnancy and to the development of the fetus. The objective of this paper is to analyze the perception of these risks during pregnancy.

Methods

We designed a survey which was answered by 42 ophthalmologists who had been working during pregnancy. We report the perception of global and specific risk according to the type of agent.

Results

38.1% of the ophthalmologists perceive that the overall risk of working during pregnancy is high, and 35.7% consider it moderate. Regarding specific risk, the most relevant agents are the ergonomic and psychosocial ones. Physical agents are considered the least important.

Conclusions

Although most of the surveyed ophthalmologists perceived the occupational risk as high or moderate, only 19% of them took time off work due to this reason. The most important agents were ergonomic and psychosocial.
目的:育龄妇女眼科医生面临不同类型的职业风险,这些风险可能对怀孕和胎儿发育有害。本文旨在分析孕期对这些风险的认识:我们设计了一项调查,由 42 名在孕期工作的眼科医生回答。结果:38.1%的眼科医生认为妊娠期存在风险,38.1%的眼科医生认为妊娠期存在风险,38.1%的眼科医生认为妊娠期存在风险:38.1%的眼科医生认为孕期工作的总体风险较高,35.7%的眼科医生认为风险适中。在具体风险方面,最相关的因素是人体工程学因素和社会心理因素。结论:尽管大多数接受调查的眼科医生认为职业风险为高或中度,但只有 19% 的人因此而请假。最重要的因素是人体工程学和社会心理因素。
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引用次数: 0
Three-year analysis of results, safety and progression in patients with open-angle glaucoma or ocular hypertension, undertaking trabecular microsurgery 对接受小梁显微手术的开角型青光眼或眼压过高患者的治疗效果、安全性和进展情况进行为期三年的分析。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.005
M. Parrilla Vallejo , J.A. Aguiar Caro , M. Girón Ortega , C.J. Cortés Laborda , M.J. Cano Gómez , P. Molina Solana , E. Rodríguez de la Rúa Franch

Aim

To evaluate the efficacy, safety, structural and functional progression following the insertion of iStent inject ® implants in patients with open-angle glaucoma or ocular hypertension at a tertiary-level hospital.

Materials and methods

A retrospective study included 98 eyes (57 males and 41 females) with open-angle glaucoma or ocular hypertension, which underwent iStent inject W® implantation (Glaukos, Corporation, CA) between December 2018 and December 2022. Differences in intraocular pressure (IOP), the number of hypotensive eye drops used, and structural and functional tests were assessed between preoperative values and subsequent reviews during a follow-up period of one (n = 98), two (n = 55), and three years (n = 15) after surgery.

Results

Among the 98 eyes studied, 85% were diagnosed with open-angle glaucoma (50% mild, 32% moderate, and 18% severe) and 15% with ocular hypertension. There was a statistically significant reduction in IOP compared to preoperative values for all visits except the 1-month (p = 0.36) and 3-year (p = 0.39) visits. Visual acuity increased from 0.39 ± 0.25 to 0.72 ± 0.24 (p < 0.01), considering that a significant portion of the interventions included cataract surgery. Before surgery, 66% of the sample used 2 or more hypotensive medications. Post-surgery, the number of hypotensive medications decreased (from 1.88 ± 0.84 to 0.21 ± 0.59 at 3 years) (p < 0.01), with an 88.9% reduction in the number of medications over three years. After surgery, 75% of cases did not require any medication.
Regarding structural and functional tests, thickness of retinal nerve fiber layers (RNFL (p = 0.35), excavation / papilla ratio E/P (p = 0.31), visual function index
(VFI (p = 0.06), and deviation mean (MD (p = 0.06) showed no statistically significant differences post-intervention. However, standard deviation of the pattern (DSM) did exhibit differences, decreasing from 5.46 ± 4.03 dB to 5.34 ± 3.48 dB (p = 0.02).

Conclusion

The results of this study suggest that the iStent inject W® technique constitutes an effective and safe option for tension control and glaucoma treatment.
目的:评估一家三级医院对开角型青光眼或眼压过高患者植入iStent inject ®植入物后的疗效、安全性、结构和功能进展:一项回顾性研究纳入了2018年12月至2022年12月期间接受iStent inject W®植入术(Glaukos公司,加利福尼亚州)的98只开角型青光眼或眼压过高的眼睛(57只男性,41只女性)。在术后一年(n = 98)、两年(n = 55)和三年(n = 15)的随访期间,对术前值与后续复查之间的眼压(IOP)差异、降压眼药水使用次数以及结构和功能测试进行了评估:在接受研究的 98 只眼睛中,85% 被诊断为开角型青光眼(50% 轻度、32% 中度和 18% 重度),15% 被诊断为眼压过高。与术前值相比,除1个月(p = 0.36)和3年(p = 0.39)检查外,所有检查的眼压均有统计学意义上的显著降低。视力从 0.39 ± 0.25 提高到 0.72 ± 0.24(p 结论:该研究结果表明,眼压降低与眼压升高有关:本研究结果表明,iStent inject W® 技术是控制眼压和治疗青光眼的有效而安全的选择。
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引用次数: 0
Suture dehiscence in patients with connective tissue disease: Marfan and Weill-Marchesani syndromes 结缔组织病患者的缝线开裂:马凡综合征和魏尔-马切桑尼综合征。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.09.002
M.M. Valentín-Pastrana Aguilar , I. Platas Moreno , N. Muñoz Sanz , B. Sandoval Cortés , J. Herrera Pereiro , I. Jiménez-Alfaro Morote
Marfan and Weill-Marchesani syndromes have a mutation of the fibrillin gene (FBN1), producing alteration of connective tissue, within ophthalmology, it is important to take into consideration this type of diseases in cogenetic alterations in this system will produce modifications at the level of the ocular structures generating problems of various types, Most of the literature refers to ectopia lentis and the complications derived from it, as secondary glaucoma.
We present two patients, one with Marfan syndrome and the other with Weill-Marchesani syndrome, who developed lens dislocation, typical of their pathologies, which led them to undergo different surgeries. Both developed suture dehiscence after these surgeries, as a complication derived from their connective tissue involvement. We thus highlight the need for vigilance and extreme caution in the postoperative period of patients affected by this type of syndromes.
马凡综合征和魏尔-马切萨尼综合征的纤维蛋白基因(FBN1)发生突变,导致结缔组织发生改变,在眼科领域,必须考虑到这类疾病,因为该系统的遗传改变会导致眼部结构发生改变,从而引发各种问题。我们介绍了两名患者,一名患有马凡氏综合征,另一名患有魏尔-马切萨尼综合征,他们都出现了晶状体脱位,这是他们的典型病症,导致他们接受了不同的手术。两人在手术后都出现了缝线开裂,这是结缔组织受累引起的并发症。因此,我们强调在此类综合征患者的术后阶段需要保持警惕和格外小心。
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引用次数: 0
Intralesional methotrexate and new approaches for neoadjuvance treatment in squamous cell periocular carcinoma 鳞状细胞眼周癌的穴内甲氨蝶呤和新辅助治疗新方法。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.007
S. López Montalbán , F. Alarcón Soldevilla , S. Abenza Baeza , M.D. Miranda Rollón , Á. López Ávila , I. Yago Ugarte
This study arises from the need to understand the different therapies for cutaneous squamous cell carcinoma (SCC), especially in challenging clinical situations where conventional therapeutic options may not be optimal. The purpose of the study is to assess the efficacy and safety of intralesional methotrexate (MTX) as neoadjuvant therapy in the treatment of periocular SCC.
The outcome of a patient after two separate intralesional MTX infiltrations 2 weeks apart is described. Therapeutic response was evaluated, achieving a significant reduction in tumor size and subsequently performing surgical excision of the residual lesion. The procedure was well tolerated, with no local or distant recurrences in the follow up.
Intralesional MTX may be an effective and safe option in the neoadjuvant treatment of periocular SCC. Furthermore, we highlight the growing importance of immunotherapy in the approach to SCC and the need to familiarize specialists with these new treatments.
这项研究是为了了解皮肤鳞状细胞癌(SCC)的不同治疗方法,尤其是在具有挑战性的临床情况下,常规治疗方法可能并非最佳选择。这项研究的目的是评估鞘内甲氨蝶呤(MTX)作为新辅助疗法治疗眼周SCC的有效性和安全性。本研究介绍了一名患者在两次MTX浸润治疗后的疗效,两次浸润治疗相隔2周。对治疗反应进行了评估,结果显示肿瘤体积明显缩小,随后对残余病灶进行了手术切除。手术耐受性良好,随访中未发现局部或远处复发。在眼周SCC的新辅助治疗中,MTX鞘内注射可能是一种有效而安全的选择。此外,我们还强调了免疫疗法在SCC治疗中日益增长的重要性,以及让专科医生熟悉这些新疗法的必要性。
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引用次数: 0
Myopic macular pit with scleral dehiscence in highly myopic patient 高度近视患者的近视黄斑凹陷与巩膜开裂[[es]]高度近视患者的近视黄斑凹陷与巩膜开裂。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.008
M. Comes-Carsí, N. Ruiz-Del Río, A.M. Duch-Samper
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引用次数: 0
Long-term results of the treatment of patients with exudative age-related macular degeneration during the COVID-19 pandemic 在 Covid-19 大流行期间治疗渗出性老年性黄斑变性患者的长期效果。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.07.004
B. Son-Camey , I. Rosado-Cerro , P. Escámez-Fernández , G. Liaño Sanz Diez de Ulzurrun , R. Montejano-Milner , C. Arruabarrena

Purpose

To quantify the long-term impact (24 months) on the visual results and activity of neovascular lesions of COVID-19 confinement in patients with nAMD in our population.

Methods

A retrospective observational study of patients with nAMD who attended consultation or were treated during the 3 months before confinement was carried out.

Results

144 patients (168 eyes) with nAMD were included, 51 of them (35.42%) came during confinement, and at 24 months the final cohort was 118 patients (133 eyes).
The previous VA of 57.99 ± 23.68 letters decreased, clinically relevant and statistically significant, by an average of 6.87 (±16.84) and 7.89 (±19.58) at 12- and 24-months follow-up. This change differs significantly from the two-year vision change observed in the national database of pretreated patients.
The median number of injections and consultations is lower in our group at 12 months, compared to the pre-pandemic national database, and tends to equalize at 24 months.
We did not find differences in vision when we compared patients who attended consultations during confinement or in treatment intervals greater than 8 weeks (Tq8w).

Conclusions

The VA of patients with nAMD decreased significantly after confinement, probably due to the lower number of antiangiogenic injections and consultations during the first year, and did not recover during the second year despite the increase in the number of injections and visits close to those reported before confinement.
目的:对我国 nAMD 患者进行 COVID-19 封闭治疗对视觉效果和新生血管病变活性的长期(24 个月)影响进行量化:方法:对禁闭前 3 个月内就诊或接受治疗的 nAMD 患者进行回顾性观察研究:结果:共纳入 144 名 nAMD 患者(168 只眼睛),其中 51 人(35.42%)是在禁闭期间就诊的。之前的视力为 57.99 ± 23.68 个字母,在 12 个月和 24 个月的随访中分别平均下降了 6.87(±16.84)和 7.89(±19.58)个字母,具有临床相关性和统计学意义。这一变化与全国预处理患者数据库中观察到的两年视力变化明显不同。与大流行前的国家数据库相比,我们小组在 12 个月时的注射和咨询次数中位数较低,在 24 个月时趋于相同。我们对在禁闭期间或治疗间隔超过 8 周(Tq8w)时就诊的患者进行了比较,没有发现视力方面的差异:nAMD患者的视力在禁闭后显著下降,这可能是由于第一年的抗血管生成注射和就诊次数较少,尽管第二年的注射和就诊次数增加到接近禁闭前的水平,但视力仍未恢复。
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引用次数: 0
Implementation of a checklist for intravitreal injections 实施玻璃体内注射检查表。
Pub Date : 2024-11-01 DOI: 10.1016/j.oftale.2024.10.001
R. Bouchikh-El Jarroudi , L. Broc Iturralde , F.J. Valentín-Bravo
{"title":"Implementation of a checklist for intravitreal injections","authors":"R. Bouchikh-El Jarroudi ,&nbsp;L. Broc Iturralde ,&nbsp;F.J. Valentín-Bravo","doi":"10.1016/j.oftale.2024.10.001","DOIUrl":"10.1016/j.oftale.2024.10.001","url":null,"abstract":"","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"99 11","pages":"Pages 469-470"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archivos de la Sociedad Espanola de Oftalmologia
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