Pub Date : 2025-10-01DOI: 10.1016/j.oftale.2025.07.013
R. Estévez-Domínguez , C. Rocha-de-Lossada , M. Rodríguez-Calvo-de-Mora , J. Etxebarria-Ecenarro , J. García-Montesinos-Gutiérrez
Keratitis-ichthyosis-deafness (KID) syndrome is a rare disease caused by mutations in the GJB2 gene. This gene encodes the protein connexin 26, which is essential for gap junctions in the epidermis, inner ear and corneal epithelium. Clinically, it is characterised by dermal hyperkeratotic lesions, sensorineural deafness and chronic keratitis that is difficult to manage. We describe two siblings diagnosed with KID syndrome who were followed up in our department for more than 15 years. Both developed numerous ocular complications associated with chronic keratitis and limbar insufficiency that required multiple keratoplasties, systemic immunosuppression and even keratoprosthesis. This case is noteworthy for the long-term follow-up of this condition and the difficult ocular management, highlighting the importance of a multidisciplinary approach and personalised therapeutic strategies.
{"title":"Ophthalmologic management in KID syndrome: Long-term clinical experience","authors":"R. Estévez-Domínguez , C. Rocha-de-Lossada , M. Rodríguez-Calvo-de-Mora , J. Etxebarria-Ecenarro , J. García-Montesinos-Gutiérrez","doi":"10.1016/j.oftale.2025.07.013","DOIUrl":"10.1016/j.oftale.2025.07.013","url":null,"abstract":"<div><div>Keratitis-ichthyosis-deafness (KID) syndrome is a rare disease caused by mutations in the GJB2 gene. This gene encodes the protein connexin 26, which is essential for gap junctions in the epidermis, inner ear and corneal epithelium. Clinically, it is characterised by dermal hyperkeratotic lesions, sensorineural deafness and chronic keratitis that is difficult to manage. We describe two siblings diagnosed with KID syndrome who were followed up in our department for more than 15 years. Both developed numerous ocular complications associated with chronic keratitis and limbar insufficiency that required multiple keratoplasties, systemic immunosuppression and even keratoprosthesis. This case is noteworthy for the long-term follow-up of this condition and the difficult ocular management, highlighting the importance of a multidisciplinary approach and personalised therapeutic strategies.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 625-629"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftale.2025.06.008
E. Garcia-Martin , M.J. Vicente Altabas , E. Vilades Palomar , E. Orduna Hospital , B. Cordon Ciordia , J. Garcia-Campayo , M. Puebla-Guedea , M. Satue Palacian
Background
Pathophysiology of fibromyalgia is still not well known. There are certain theories than point out a possible neurodegeneration component.
Objectives
To evaluate variations in visual function parameters and in the macular ganglion cell layer (CGR) of patients with fibromyalgia (FM) over a period of 5 years, and compare these results with controls.
Methods
85 patients with FM and 41 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity (VA) with ETDRS, contrast sensitivity vision (CSV) with Pelli Robson, color vision with Farnsworth and Lanthony D15 tests and retinal evaluation using Cirrus HD-OCT 3000 (Carl Zeiss, California). All subjects were re-evaluated after 5 years. It was also analyzed the association between progressive structural, functional and disease severity changes. Furthermore, patients were classified into three groups (1, atypical; 2, depressive; 3, biologic).
Results
Progressive changes were detected in visual function parameters and CGR thickness in FM patients after 5 years. Patients with FM presented worse low contrast VA (p = 0.022), color discrimination (Lanthony’s C index, p = 0.006) and decreased CGR thickness (nasal inferior, p < 0.001) over the follow up time, compared with controls. Changes in color vision were associated with CGR thinning, but no correlations with disease severity were observed.
Conclusions
It has been noticed progressive visual dysfunction and CGR loss in patients suffering from FM. The analysis of visual function parameters and CGR thickness using Cirrus OCT could be of value to control FM disease.
{"title":"Progressive visual dysfunction and retinal neurodegeneration in patients with fibromyalgia","authors":"E. Garcia-Martin , M.J. Vicente Altabas , E. Vilades Palomar , E. Orduna Hospital , B. Cordon Ciordia , J. Garcia-Campayo , M. Puebla-Guedea , M. Satue Palacian","doi":"10.1016/j.oftale.2025.06.008","DOIUrl":"10.1016/j.oftale.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Pathophysiology of fibromyalgia is still not well known. There are certain theories than point out a possible neurodegeneration component.</div></div><div><h3>Objectives</h3><div>To evaluate variations in visual function parameters and in the macular ganglion cell layer (CGR) of patients with fibromyalgia (FM) over a period of 5 years, and compare these results with controls.</div></div><div><h3>Methods</h3><div>85 patients with FM and 41 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity (VA) with ETDRS, contrast sensitivity vision (CSV) with Pelli Robson, color vision with Farnsworth and Lanthony D15 tests and retinal evaluation using Cirrus HD-OCT 3000 (Carl Zeiss, California). All subjects were re-evaluated after 5 years. It was also analyzed the association between progressive structural, functional and disease severity changes. Furthermore, patients were classified into three groups (1, atypical; 2, depressive; 3, biologic).</div></div><div><h3>Results</h3><div>Progressive changes were detected in visual function parameters and CGR thickness in FM patients after 5 years. Patients with FM presented worse low contrast VA (p = 0.022), color discrimination (Lanthony’s C index, p = 0.006) and decreased CGR thickness (nasal inferior, p < 0.001) over the follow up time, compared with controls. Changes in color vision were associated with CGR thinning, but no correlations with disease severity were observed.</div></div><div><h3>Conclusions</h3><div>It has been noticed progressive visual dysfunction and CGR loss in patients suffering from FM. The analysis of visual function parameters and CGR thickness using Cirrus OCT could be of value to control FM disease.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 601-609"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftale.2025.07.007
J. Moya-Roca , M. Lledó-Riquelme , E. Campos-Mollo , J. Hernández-Jiménez , C. Porcar-Plana , M. Lledó-Carreres , E. Navarro-Hernández
Acute acquired comitant esotropia is a rare manifestation of strabismus that has been used to describe an acute late-onset of esotropia with diplopia in a previously orthotropic individual. It often occurs in older children and adults and has been associated with multiple etiologies. Despite the multiple reports conducted its cause is still controversial. We describe a young patient with epidemic keratoconjunctivitis with an acute comitant esotropia. He had no underlying diseases and regained stereo acuity after surgical alignment of both eyes.
{"title":"Acute esotropia concurrent with adenoviral keratoconjunctivitis","authors":"J. Moya-Roca , M. Lledó-Riquelme , E. Campos-Mollo , J. Hernández-Jiménez , C. Porcar-Plana , M. Lledó-Carreres , E. Navarro-Hernández","doi":"10.1016/j.oftale.2025.07.007","DOIUrl":"10.1016/j.oftale.2025.07.007","url":null,"abstract":"<div><div>Acute acquired comitant esotropia is a rare manifestation of strabismus that has been used to describe an acute late-onset of esotropia with diplopia in a previously orthotropic individual. It often occurs in older children and adults and has been associated with multiple etiologies. Despite the multiple reports conducted its cause is still controversial. We describe a young patient with epidemic keratoconjunctivitis with an acute comitant esotropia. He had no underlying diseases and regained stereo acuity after surgical alignment of both eyes.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 640-643"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacteria isolated in postoperative endophthalmitis (PE) were reduced to cefuroxime-resistant bacteria in cataract surgery with intracameral cefuroxime as prophylaxis; age > 84 years was at risk for PEs caused by Gram-negative-bacteria and Staphylococci; no risks were identified for Enterococci, the most abundant isolations. The prevalence of Enterococci in the preoperative conjunctiva was associated with age > 74 years, diabetes, obesity, and dacryocystorhinostomy-history (DCR-history). The aim of the study is to differentiate the risk of age from that of other patient characteristics, establishing 2 different age groups.
Materials and methods
We conducted a retrospective cross-sectional study in a tertiary referral center. In 7,085 patients < 75 years old and 7,798 ≥ 75 years, the incidence rate ratio (IRR) of Enterococci, Enterobacteriaceae, Non-fermentative-Gram-negative-bacilli (NFGNB) and Coagulase-negative-Staphylococci (CNS) was calculated for the following factors: diabetes, obesity, DCR-history, sex-male, smoking-habit, and climate, using multivariate Poisson regression, IBM SPSS Statistic for Windows, version 25.0. Armonk, NY: IBM Corp.
Results
Diabetes, obesity, male-sex and smoking-habit were more prevalent in patients < 75 years old. The IRRs of Enterococci, Enterobacteriaceae and NFGNB were higher in this age group: [Enterococci IRRs: diabetes, 1.54 vs 1.42; obesity, 2.95 vs 1.50; DCR-history, 3.78 vs 1.08]; [Enterobacteriaceae IRRs: diabetes, 1.47 vs 1.13; obesity, 2.27 vs 1.99; male-sex, 1.76 vs 1.65]; [NFGNB IRRs: diabetes, 1.79 vs 1.16; autumn-weather, 2.05 vs 1.56]. Diabetes-obesity simultaneously: Enterobacteriaceae IRR, 3.30 vs 2.28; Enterococci IRR, 3.28 vs 1.62.
Conclusions
Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients < 75 years more than they actually do in patients ≥ 75.
背景与目的：白内障术后眼内炎（PE）中分离的细菌减少为头孢呋辛耐药菌；年龄0 ~ 84岁存在革兰氏阴性菌和葡萄球菌所致PEs的风险；未发现最丰富的分离株肠球菌的风险。术前结膜中肠球菌的流行与年龄、糖尿病、肥胖和泪囊造口史（DCR-history）有关。该研究的目的是区分年龄与其他患者特征的风险，建立了两个不同的年龄组。材料和方法：我们在一家三级转诊中心进行了回顾性横断面研究。在7085例< 75岁和7798例≥75岁的患者中，计算肠球菌、肠杆菌科、非发酵革兰氏阴性杆菌（NFGNB）和凝固酶阴性葡萄球菌（CNS）的发病率比（IRR），考虑以下因素：糖尿病、肥胖、dcr病史、性别-男性、吸烟习惯和气候，采用多变量泊松回归，IBM SPSS Statistic for Windows，版本25.0。结果：糖尿病、肥胖、男性性行为和吸烟习惯在< 75岁的患者中更为普遍。该年龄组肠球菌、肠杆菌科和NFGNB的IRRs较高：[肠球菌：糖尿病，1.54 vs 1.42；肥胖，2.95比1.50；dcr -病史（3.78 vs 1.08）；[肠杆菌科IRRs：糖尿病，1.47 vs 1.13；肥胖，2.27 vs 1.99；男性（1.76 vs 1.65）；[NFGNB irs：糖尿病，1.79 vs 1.16；秋天的天气，2.05 vs 1.56]。糖尿病-肥胖同时发生：肠杆菌科IRR， 3.30 vs 2.28；肠球菌IRR为3.28 vs 1.62。结论：糖尿病、肥胖和有dcr病史的患者< 75岁时肠球菌、肠杆菌科和NFGNB的IRR高于≥75岁患者。
{"title":"Risk of conjunctival colonization by cefuroxime-resistant bacteria in cataract surgery patients younger than 75 years and aged 75 or older","authors":"J.L. Urcelay-Segura , J.M. Bellón-Cano , T. Cuesta-Rodríguez , M.E. Fernández-Rubio","doi":"10.1016/j.oftale.2025.08.006","DOIUrl":"10.1016/j.oftale.2025.08.006","url":null,"abstract":"<div><h3>Background and objective</h3><div>Bacteria isolated in postoperative endophthalmitis (PE) were reduced to cefuroxime-resistant bacteria in cataract surgery with intracameral cefuroxime as prophylaxis; age > 84 years was at risk for PEs caused by Gram-negative-bacteria and Staphylococci; no risks were identified for Enterococci, the most abundant isolations. The prevalence of Enterococci in the preoperative conjunctiva was associated with age > 74 years, diabetes, obesity, and dacryocystorhinostomy-history (DCR-history). The aim of the study is to differentiate the risk of age from that of other patient characteristics, establishing 2 different age groups.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective cross-sectional study in a tertiary referral center. In 7,085 patients < 75 years old and 7,798 ≥ 75 years, the incidence rate ratio (IRR) of Enterococci, Enterobacteriaceae, Non-fermentative-Gram-negative-bacilli (NFGNB) and Coagulase-negative-Staphylococci (CNS) was calculated for the following factors: diabetes, obesity, DCR-history, sex-male, smoking-habit, and climate, using multivariate Poisson regression, IBM SPSS Statistic for Windows, version 25.0. Armonk, NY: IBM Corp.</div></div><div><h3>Results</h3><div>Diabetes, obesity, male-sex and smoking-habit were more prevalent in patients < 75 years old. The IRRs of Enterococci, Enterobacteriaceae and NFGNB were higher in this age group: [Enterococci IRRs: diabetes, 1.54 vs 1.42; obesity, 2.95 vs 1.50; DCR-history, 3.78 vs 1.08]; [Enterobacteriaceae IRRs: diabetes, 1.47 vs 1.13; obesity, 2.27 vs 1.99; male-sex, 1.76 vs 1.65]; [NFGNB IRRs: diabetes, 1.79 vs 1.16; autumn-weather, 2.05 vs 1.56]. Diabetes-obesity simultaneously: Enterobacteriaceae IRR, 3.30 vs 2.28; Enterococci IRR, 3.28 vs 1.62.</div></div><div><h3>Conclusions</h3><div>Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients < 75 years more than they actually do in patients ≥ 75.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 592-600"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftale.2025.07.014
J.L. Sánchez-Vicente, M. Portillo-Martínez, J.V. Guijarro-Ambel, E.M. Gámez-Jiménez, E. Cosano-Palma, F. López-Herrero
Perforation of the eyeball during retrobulbar anesthesia is rarely reported. A case of inadvertent ocular perforation during retrobulbar anesthesia in cataract surgery is presented. Retinal complications and follow up after six months are described.
A 58-year-old man presented with vision loss following cataract surgery on his right eye by phacoemulsification and intraocular lens implantation under retrobulbar anaesthesia performed one week earlier. Visual acuity was 0.05. Fundus examination revealed a vitreous haemorrhage in the lower area. A rounded haemorrhage was present next to the lower temporal arcade with a possible entry orifice. Optical coherence tomography, tomographic angiography and fluorescein angiography showed retinal ischaemia in the juxtapapillary macular area.
The patient was followed for 6 months. Visual acuity improved to 0.5. Optical coherence tomography and tomographic angiography showed a reduction of the edema in the retinal layers, with a persistent loss of the inner nuclear and outer plexiform layer.
Accidental intravitreal injection of bupivacaine and lidocaine during retrobulbar anaesthesia can result in permanent visual impairment. Extreme attention should be paid to the injection technique to avoid this complication.
{"title":"Macular ischaemia after inadvertent perforation of the eyeball and intravitreal injection of anesthetic agents during retrobulbar anaesthesia","authors":"J.L. Sánchez-Vicente, M. Portillo-Martínez, J.V. Guijarro-Ambel, E.M. Gámez-Jiménez, E. Cosano-Palma, F. López-Herrero","doi":"10.1016/j.oftale.2025.07.014","DOIUrl":"10.1016/j.oftale.2025.07.014","url":null,"abstract":"<div><div>Perforation of the eyeball during retrobulbar anesthesia is rarely reported. A case of inadvertent ocular perforation during retrobulbar anesthesia in cataract surgery is presented. Retinal complications and follow up after six months are described.</div><div>A 58-year-old man presented with vision loss following cataract surgery on his right eye by phacoemulsification and intraocular lens implantation under retrobulbar anaesthesia performed one week earlier. Visual acuity was 0.05. Fundus examination revealed a vitreous haemorrhage in the lower area. A rounded haemorrhage was present next to the lower temporal arcade with a possible entry orifice. Optical coherence tomography, tomographic angiography and fluorescein angiography showed retinal ischaemia in the juxtapapillary macular area.</div><div>The patient was followed for 6 months. Visual acuity improved to 0.5. Optical coherence tomography and tomographic angiography showed a reduction of the edema in the retinal layers, with a persistent loss of the inner nuclear and outer plexiform layer.</div><div>Accidental intravitreal injection of bupivacaine and lidocaine during retrobulbar anaesthesia can result in permanent visual impairment. Extreme attention should be paid to the injection technique to avoid this complication.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 630-635"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftale.2025.07.009
P. Moreira Martins, C. Ferreira, E. Saraiva, P. Sepúlveda, L. Silva, F. Sousa-Neves
Introduction and objectives
Retinitis pigmentosa (RP) represents a spectrum of rod-cone inherited disorders with characteristic symptoms, and functional changes. The Asp-190-Tyr pathogenic variant of the RHO gene impairs rodopsin transport through the endoplasmic reticulum, leading to accumulation within photoreceptors, inducing cytotoxicity. This report presents the ophthalmologic phenotype of this rare variant.
Materials and methods
Retrospective study including patients from one extended family presenting with RP, with an autosomal dominant (AD) variant of the RHO gene (Asp-190-tyr). Baseline demographic/ophthalmologic data and ancillary testing was collected.
Results
Twelve individuals were included; eight had generalized RP. The mean age was 64 years - four were female. Genetic testing in 5/8 patients with RP revealed an AD variant in the RHO gene, with replacement of an aspartic acid with tyrosine at codon 190. Visual acuity ranged from no light perception to 6/10. Fundoscopy and fundus autofluorescence showed bilateral generalized RP pattern: optic disc pallor, bone spicules, and arterial narrowing. Perimetry in four patients showed tunnel vision. Electrophysiology revealed marked wave reduction in both pattern and flash ERG. Severe atrophy of the outer retinal layers with cystoid macular oedema was observed in 4/8 patients.
Conclusions
This study highlights the phenotype of the Asp-190-Tyr variant. Previously, it was described in a family with a regional pattern of RP and relatively preserved visual function. Our study changes this paradigm, with patients presenting with a generalized RP phenotype and significant visual impairment. The provided data may help offer accurate prognostic information to patients with this variant.
{"title":"Autosomal dominant retinitis pigmentosa: An extended family report of the Asp-190-Tyr variant","authors":"P. Moreira Martins, C. Ferreira, E. Saraiva, P. Sepúlveda, L. Silva, F. Sousa-Neves","doi":"10.1016/j.oftale.2025.07.009","DOIUrl":"10.1016/j.oftale.2025.07.009","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Retinitis pigmentosa (RP) represents a spectrum of rod-cone inherited disorders with characteristic symptoms, and functional changes. The Asp-190-Tyr pathogenic variant of the RHO gene impairs rodopsin transport through the endoplasmic reticulum, leading to accumulation within photoreceptors, inducing cytotoxicity. This report presents the ophthalmologic phenotype of this rare variant.</div></div><div><h3>Materials and methods</h3><div>Retrospective study including patients from one extended family presenting with RP, with an autosomal dominant (AD) variant of the RHO gene (Asp-190-tyr). Baseline demographic/ophthalmologic data and ancillary testing was collected.</div></div><div><h3>Results</h3><div>Twelve individuals were included; eight had generalized RP. The mean age was 64 years - four were female. Genetic testing in 5/8 patients with RP revealed an AD variant in the RHO gene, with replacement of an aspartic acid with tyrosine at codon 190. Visual acuity ranged from no light perception to 6/10. Fundoscopy and fundus autofluorescence showed bilateral generalized RP pattern: optic disc pallor, bone spicules, and arterial narrowing. Perimetry in four patients showed tunnel vision. Electrophysiology revealed marked wave reduction in both pattern and flash ERG. Severe atrophy of the outer retinal layers with cystoid macular oedema was observed in 4/8 patients.</div></div><div><h3>Conclusions</h3><div>This study highlights the phenotype of the Asp-190-Tyr variant. Previously, it was described in a family with a regional pattern of RP and relatively preserved visual function. Our study changes this paradigm, with patients presenting with a generalized RP phenotype and significant visual impairment. The provided data may help offer accurate prognostic information to patients with this variant.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 585-591"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.oftale.2025.07.004
Javier Garulo Nicolás , Laura Manfreda Domínguez , Patricia Bayo Calduch , Sergio Obiol Ferrando , Andrea Català Nadal , Antonio Miguel Duch Samper
Papillary drusen are deposits of calcified hyaline material at the level of the optic nerve head. They are considered the most frequent cause of pseudopapilledema, so in clinical practice it is essential to identify and differentiate them from true optic disc oedema.
Parainfectious optic neuritis is an inflammatory optic neuropathy, usually bilateral and acute, which occurs between 1 and 3 weeks after an infectious disease. It usually occurs as a papillitis, since it is usually located in the head of the optic nerve causing optic disc oedema.
In this article we present an unusual case of bilateral papillitis superimposed on papillary drusen in a young male with Chlamydia trachomatis prostatitis. After an exhaustive etiological study, it was concluded that, in this patient, papillitis was associated with his sexually transmitted disease.
{"title":"Bilateral parainfectious papillitis superimposed on papillary pseudoedema by optic nerve drusen","authors":"Javier Garulo Nicolás , Laura Manfreda Domínguez , Patricia Bayo Calduch , Sergio Obiol Ferrando , Andrea Català Nadal , Antonio Miguel Duch Samper","doi":"10.1016/j.oftale.2025.07.004","DOIUrl":"10.1016/j.oftale.2025.07.004","url":null,"abstract":"<div><div>Papillary drusen are deposits of calcified hyaline material at the level of the optic nerve head. They are considered the most frequent cause of pseudopapilledema, so in clinical practice it is essential to identify and differentiate them from true optic disc oedema.</div><div>Parainfectious optic neuritis is an inflammatory optic neuropathy, usually bilateral and acute, which occurs between 1 and 3 weeks after an infectious disease. It usually occurs as a papillitis, since it is usually located in the head of the optic nerve causing optic disc oedema.</div><div>In this article we present an unusual case of bilateral papillitis superimposed on papillary drusen in a young male with <em>Chlamydia trachomatis</em> prostatitis. After an exhaustive etiological study, it was concluded that, in this patient, papillitis was associated with his sexually transmitted disease.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 9","pages":"Pages 558-562"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.oftale.2025.07.005
D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano
A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.
{"title":"Stargardt disease due to ABCA4 mutation in a young adult: Case report and current alternatives for optical and medical treatments","authors":"D.V. Rey-Rodriguez , M.I. Gómez-Buitrago , M.J. Mateus Parra , L.A. Pazmiño La Rotta , L.F. Aguilar-Serrano","doi":"10.1016/j.oftale.2025.07.005","DOIUrl":"10.1016/j.oftale.2025.07.005","url":null,"abstract":"<div><div>A patient with low vision has been followed by the optometry, ophthalmology, and genetics services since the age of 9, with a diagnosis of Stargardt disease. During follow-up, multiple tests have been performed: ocular angiography, genetic analysis, and visual evoked potential studies. The patient presents with a disease compatible with macular dystrophy, associated with the ABCA4 gene, which is slowly progressive and currently irreversible, with no effective treatment available. The patient is currently managed for low vision and has visual aids that allow them to function in daily life and develop professionally. The focus on low vision management in patients with diseases that irreversibly affect vision is of great importance to ensure these patients can achieve proper development in society.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 9","pages":"Pages 571-575"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.oftale.2025.07.010
S. Amatha , R. Das , M.K. Gautam , S. Mondal
Recent years have witnessed remarkable advancements in biotechnological ocular drug delivery systems, introducing novel strategies such as gene therapy, cell-based systems, and targeted carriers. This article focuses specifically on age-related macular degeneration (AMD), the most prevalent ocular condition. While gene therapy holds promise for AMD treatment, it also presents significant challenges, leading to the exploration of cell-based therapy as a complementary or alternative approach. To address these hurdles and ensure successful market translation, new companies often form collaborative expert teams encompassing all relevant fields, including regulatory affairs. As medical science continues to evolve, a comprehensive understanding of gene therapy, cell-based delivery, biocompatibility, safety considerations, regulatory aspects, and ongoing clinical trials is essential to fully grasp the safety and effectiveness of these novel ocular therapies. Consequently, this paper primarily explores these key areas. The successful evolution of biotechnological ocular delivery signals a positive shift towards personalized medicine, which is expected to significantly improve the quality of life for AMD patients in the near future.
{"title":"Biotechnological novel drug delivery systems for age-related macular degeneration","authors":"S. Amatha , R. Das , M.K. Gautam , S. Mondal","doi":"10.1016/j.oftale.2025.07.010","DOIUrl":"10.1016/j.oftale.2025.07.010","url":null,"abstract":"<div><div>Recent years have witnessed remarkable advancements in biotechnological ocular drug delivery systems, introducing novel strategies such as gene therapy, cell-based systems, and targeted carriers. This article focuses specifically on age-related macular degeneration (AMD), the most prevalent ocular condition. While gene therapy holds promise for AMD treatment, it also presents significant challenges, leading to the exploration of cell-based therapy as a complementary or alternative approach. To address these hurdles and ensure successful market translation, new companies often form collaborative expert teams encompassing all relevant fields, including regulatory affairs. As medical science continues to evolve, a comprehensive understanding of gene therapy, cell-based delivery, biocompatibility, safety considerations, regulatory aspects, and ongoing clinical trials is essential to fully grasp the safety and effectiveness of these novel ocular therapies. Consequently, this paper primarily explores these key areas. The successful evolution of biotechnological ocular delivery signals a positive shift towards personalized medicine, which is expected to significantly improve the quality of life for AMD patients in the near future.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 9","pages":"Pages 537-548"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.oftale.2025.07.008
O. Teherán , C. Parra , E. Ramos , M. Ochoa , W. Escobar
Purpose
To evaluate the effectiveness and safety of mitomycin C (MMC) use when implanting Ahmed valve in patients with refractory glaucoma.
Methods
Cohort study involving 34 patients divided into two groups of 17 patients each: Group 1 (MMC use) and Group 2 (no MMC use), with a one-year follow-up. Complete success was defined as intraocular pressure (IOP) between 6−18 mmHg without the use of antiglaucoma medications; qualified success referred to the same IOP range but associated with antiglaucoma medications, while failure was characterized by IOP outside this range, severe complications or reintervention.
Results
The overall success rate in Group 1 was 88.2%, and in Group 2, 94.2%. There was an average reduction in IOP of 18.0-± 11.5 mmHg in Group 1 and 11.3 ± 5.0 mmHg in Group 2. The hypertensive phase occurred in 17.6% of the participants in the first group and the second, 70.6%.
Conclusions
The use of MMC decreases the hypertensive phase observed in Ahmed valve implant surgery, thereby achieving better IOP control.
{"title":"Evaluation of the effectiveness of Ahmed's valve implantation adding mitomicin C in patients with refractory glaucoma after one year of follow-up","authors":"O. Teherán , C. Parra , E. Ramos , M. Ochoa , W. Escobar","doi":"10.1016/j.oftale.2025.07.008","DOIUrl":"10.1016/j.oftale.2025.07.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effectiveness and safety of mitomycin C (MMC) use when implanting Ahmed valve in patients with refractory glaucoma.</div></div><div><h3>Methods</h3><div>Cohort study involving 34 patients divided into two groups of 17 patients each: Group 1 (MMC use) and Group 2 (no MMC use), with a one-year follow-up. Complete success was defined as intraocular pressure (IOP) between 6−18 mmHg without the use of antiglaucoma medications; qualified success referred to the same IOP range but associated with antiglaucoma medications, while failure was characterized by IOP outside this range, severe complications or reintervention.</div></div><div><h3>Results</h3><div>The overall success rate in Group 1 was 88.2%, and in Group 2, 94.2%. There was an average reduction in IOP of 18.0-± 11.5 mmHg in Group 1 and 11.3 ± 5.0 mmHg in Group 2. The hypertensive phase occurred in 17.6% of the participants in the first group and the second, 70.6%.</div></div><div><h3>Conclusions</h3><div>The use of MMC decreases the hypertensive phase observed in Ahmed valve implant surgery, thereby achieving better IOP control.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 9","pages":"Pages 521-527"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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