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Proteomic signatures of sweetened beverages are associated with higher risk of adverse liver outcomes 含糖饮料的蛋白质组特征与肝脏不良后果的高风险相关
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-01 DOI: 10.1038/s43016-025-01266-0
Longgang Zhao, Xinyuan Zhang, Jiali Zheng, Yun Chen, Danielle E. Haslam, Hongmei Zeng, Shilpa N. Bhupathiraju, Frank B. Hu, Deirdre K. Tobias, Katherine A. McGlynn, Xuehong Zhang
Evidence is limited on the associations between the consumption of sweetened beverages, their proteomic signatures and liver health. We used data from the UK Biobank with 173,840 participants aged 40–69 years and applied Cox proportional hazards regression to examine associations of sugar- and artificially sweetened beverages, along with their proteomic signatures (derived from elastic net regressions), with adverse liver outcomes. After a median follow-up of 8.9 years, 1 serving increment of both sugar- and artificially sweetened beverages per day was positively associated with risk of metabolic dysfunction-associated steatotic liver disease, severe liver disease and chronic liver disease mortality. The proteomic signatures of sugar- and artificially sweetened beverages showed positive associations with risk of metabolic dysfunction-associated steatotic liver disease, liver cirrhosis and severe liver disease. Our results suggest the potential importance of reducing sweetened beverage intake to improve liver health. This study examines associations between sugar- and artificially sweetened beverages or proteomic signatures and adverse liver outcomes using UK Biobank data. The findings highlight the potential benefits of reducing sweetened beverage intake for liver health.
关于含糖饮料的消费、其蛋白质组特征和肝脏健康之间的关联的证据有限。我们使用了来自英国生物银行的173840名年龄在40-69岁之间的参与者的数据,并应用Cox比例风险回归来检查含糖和人工加糖饮料及其蛋白质组学特征(来自弹性净回归)与不良肝脏结局的关系。在平均8.9年的随访后,每天增加1份含糖饮料和人工加糖饮料与代谢功能障碍相关的脂肪变性肝病、严重肝病和慢性肝病死亡率呈正相关。含糖饮料和人工加糖饮料的蛋白质组学特征显示,与代谢功能障碍相关的脂肪变性肝病、肝硬化和严重肝病的风险呈正相关。我们的研究结果表明,减少含糖饮料的摄入对改善肝脏健康具有潜在的重要性。本研究使用UK Biobank的数据检查了糖和人工加糖饮料或蛋白质组学特征与不良肝脏结局之间的关系。研究结果强调了减少含糖饮料摄入对肝脏健康的潜在好处。
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引用次数: 0
Climate–workforce nexus at the centre of food systems resilience 气候-劳动力关系是粮食系统恢复力的核心
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-01 DOI: 10.1038/s43016-025-01272-2
Yin Long  (, ), Kexin Liu  (, ), Minghao Zhuang  (, ), Yuya Kajikawa  (, ), Yoshikuni Yoshida  (, )
Extreme heat is intensifying occupational risks across global agriculture, yet adaptation efforts remain disproportionately crop-centric. Existing frameworks largely ignore the physiological limits, economic constraints and structural exposures faced by frontline labourers. A shift towards climate-resilient mechanization, quantified health-loss integration and redistributive adaptation policy is essential to safeguard the human foundation of food systems.
极端高温正在加剧全球农业的职业风险,但适应工作仍然不成比例地以作物为中心。现有的框架在很大程度上忽视了一线劳动者面临的生理限制、经济约束和结构性风险。向适应气候变化的机械化、量化的健康损失整合和再分配适应政策转变,对于保护粮食系统的人类基础至关重要。
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引用次数: 0
Agricultural research approaches for crops that nourish by improving nutrition, soil health, resilience and prosperity 通过改善营养、土壤健康、恢复力和繁荣来滋养作物的农业研究方法
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-26 DOI: 10.1038/s43016-025-01271-3
Kate Schneider Lecy, Francisco Alarcón Gonzalez, Inbal Becker-Reshef, Lydia Mumbi Chabala, Juliana J. Cheboi, Vimbayi Grace Petrova Chimonyo, Eric Y. Danquah, Riley Demo, John Saviour Yaw Eleblu, Evan Fraser, Abe Shegro Gerrano, Tinovonga Gonhi, Timothy Griffin, Günter Hemrich, Aristide Carlos Houdegbe, Gina Kennedy, Alpha Yayah Mansaray, Mduduzi N. N. Mbuya, Kevin Murphy, Anna Nelson, Hambulo Ngoma, Danielle Nierenberg, Tiffany Oliver, Mavis Owusuaa Osei-Wusu, Natalia Palacios, Laura Vang Rasmussen, Fred Rattunde, Paul Rogé, Julia Sibiya, Melinda Smale, Martin Paul Tabe-Ojong Jr., Andrew L. Thorne-Lyman, Emilie Vansant, Eva Weltzien, Ayala Wineman, Sieglinde Snapp
Addressing nutrition and climate resilience together requires transdisciplinary participatory action research with clear impact pathways for systems change that starts from the ground up. The concept of ‘crops that nourish’ is proposed here to offer a new mode of pursuing agricultural development. It involves iterative co-creation between farmers and researchers that prioritizes local needs and agency, human health, resilience and sustainability through a focus on opportunity crops.
共同解决营养和气候适应能力问题需要跨学科的参与性行动研究,并为从头开始的系统变革提供明确的影响途径。提出“滋养作物”的概念,为农业发展提供了一种新的模式。它涉及农民和研究人员之间的反复共同创造,通过重点关注机会作物,优先考虑当地需求和机构、人类健康、复原力和可持续性。
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引用次数: 0
Protecting the high seas 保护公海
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-20 DOI: 10.1038/s43016-025-01269-x
The High Seas Treaty, key to the conservation of international waters, will come into effect in January 2026. The full implications for food systems remain to be explored.
《公海条约》是保护国际水域的关键,将于2026年1月生效。对粮食系统的全面影响仍有待探讨。
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引用次数: 0
Bacterial richness for enhanced soil carbon storage 细菌丰富度对提高土壤碳储量的影响
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-18 DOI: 10.1038/s43016-025-01247-3
Zhenhui Jiang, Anna Gunina
Bacterial richness is a key driver of soil organic matter stability, as it promotes the formation of more thermodynamically stable yet less diverse compounds, thereby playing a central role in sustaining long-term soil carbon storage.
细菌丰富度是土壤有机质稳定性的关键驱动因素,因为它促进了更多热力学稳定但多样性较少的化合物的形成,从而在维持长期土壤碳储存中发挥核心作用。
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引用次数: 0
Bacterial richness enhances the thermostability of soil organic matter via a long-term trade-off between molecular diversity and thermodynamic stability 细菌丰富度通过分子多样性和热力学稳定性之间的长期权衡来增强土壤有机质的热稳定性
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-18 DOI: 10.1038/s43016-025-01253-5
Meng Wu, Emanuele Lugato, Pengfa Li, Jia Liu, Cunpu Qiu, Shuang Wang, Xingzhu Ma, Xiaoyu Hao, Ming Liu, Jun Shan, Xiaoyuan Yan, Zhongpei Li
The persistence of soil organic matter (SOM) is shaped by its molecular features and stability, but the temporal dynamics of these features remain unclear. Here we investigate the molecular diversity (the number of molecules) and molecular thermodynamic stability (the theoretical Gibbs free energy for the half reaction of carbon oxidation) of SOM in soils from long-term (>30 years) paddy and upland experimental fields. Thermogravimetric analysis shows that enhanced SOM thermostability aligns with the temporal variation of molecular thermodynamic stability in these soils. Increased SOM molecular thermodynamic stability occurs alongside decreased molecular diversity over decades, and this temporal trade-off (negative relationship) is modulated by increased bacterial richness. These findings highlight the role of microbial diversity in enhancing SOM thermostability and support strategies that promote bacterial richness for improved SOM persistence in agriculture. Soil organic matter stability is critical for long-term soil health and carbon sequestration. This study reveals that increased bacterial richness enhances soil organic matter thermostability by driving a trade-off between molecular diversity and thermodynamic stability.
土壤有机质(SOM)的持久性是由其分子特征和稳定性决定的,但这些特征的时间动态尚不清楚。本文研究了长期(>;30年)水田和旱田土壤中SOM的分子多样性(分子数量)和分子热力学稳定性(碳氧化半反应的理论吉布斯自由能)。热重分析表明,SOM热稳定性的增强与土壤分子热力学稳定性的时间变化一致。几十年来,SOM分子热力学稳定性的增加与分子多样性的减少同时发生,这种时间权衡(负相关关系)被细菌丰富度的增加所调节。这些发现强调了微生物多样性在提高SOM热稳定性中的作用,并支持了促进细菌丰富度以提高SOM在农业中的持久性的策略。土壤有机质稳定性对土壤长期健康和固碳至关重要。该研究表明,细菌丰富度的增加通过驱动分子多样性和热力学稳定性之间的权衡来增强土壤有机质的热稳定性。
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引用次数: 0
Time unlocks bovine fibroblast immortality to pave the way for cultivated beef 时间开启了牛成纤维细胞的不朽,为培育牛肉铺平了道路
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-17 DOI: 10.1038/s43016-025-01256-2
We demonstrate that bovine fibroblasts can undergo spontaneous immortalization after 500 days in culture, without genetic modification or p53 inactivation. These rare events provide a safe, stable and economically viable cell source that overcomes key barriers to cultivated beef production.
我们证明牛成纤维细胞在培养500天后可以进行自发永生化,而不需要基因修饰或p53失活。这些罕见的事件提供了一种安全、稳定和经济上可行的细胞来源,克服了养殖牛肉生产的主要障碍。
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引用次数: 0
Oat protein nanofibrils as a plant-based solution for iron fortification 燕麦蛋白纳米原纤维作为植物性铁强化溶液
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-17 DOI: 10.1038/s43016-025-01265-1
Food fortified with iron has the potential to correct iron deficiency and associated anaemia, yet it remains challenging to ensure acceptable iron absorption without compromising the sensory properties of the modified food. Stable oat protein nanofibrils carrying ultrasmall iron nanoparticles deliver highly bioavailable iron with minimal changes in colour and taste, offering a promising strategy for global iron fortification.
含铁强化食品有可能纠正缺铁和相关贫血,但在不影响改性食品感官特性的情况下确保可接受的铁吸收仍然具有挑战性。稳定的燕麦蛋白纳米原纤维携带超小的铁纳米颗粒,在颜色和味道变化极小的情况下提供高度生物可利用的铁,为全球铁强化提供了一种有前途的策略。
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引用次数: 0
Adjustments, evidence and political tensions in the US Supplemental Nutrition Assistance Program 美国补充营养援助计划中的调整、证据和政治紧张局势
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-13 DOI: 10.1038/s43016-025-01258-0
Vincenzina Caputo, David R. Just
The Supplemental Nutrition Assistance Program (SNAP) plays a key role in the US food system. As Congress considers major changes to it under the 2025 One Big Beautiful Bill Act and states propose restrictions on what benefits may be used to purchase food, SNAP sits at the intersection of food security, labour market policy and public health. Drawing on historical experience and empirical economic evidence, we assess the impact of the proposed changes on SNAP, showing that specific policy solutions could improve outcomes without increasing programme costs, while simplified enrolment procedures could increase programme participation and reduce food insecurity. Recent policy changes in the USA have reignited long-standing debates surrounding the Supplemental Nutrition Assistance Program (SNAP). This Review assesses the potential impact of these changes and identifies priorities for further improving SNAP’s effectiveness and reach.
补充营养援助计划(SNAP)在美国食品系统中起着关键作用。随着国会考虑根据《2025年一个大美丽法案》(2025 One Big Beautiful Bill Act)对该计划进行重大修改,以及各州提出限制可用于购买食品的福利,SNAP处于食品安全、劳动力市场政策和公共卫生的交叉点。根据历史经验和经验性经济证据,我们评估了拟议的变化对SNAP的影响,表明具体的政策解决方案可以在不增加计划成本的情况下改善结果,而简化的登记程序可以增加计划参与并减少粮食不安全。美国最近的政策变化重新点燃了长期以来围绕补充营养援助计划(SNAP)的争论。本审查评估了这些变化的潜在影响,并确定了进一步提高SNAP有效性和覆盖面的优先事项。
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引用次数: 0
Spontaneous immortalization of bovine fibroblasts following long-term expansion offers a non-transformed cell source for cultivated beef 牛成纤维细胞在长期扩增后的自发永生为培养牛肉提供了一种非转化细胞来源
IF 21.9 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-11-12 DOI: 10.1038/s43016-025-01255-3
Laura Pasitka, Merav Cohen, Shaun Regenbaum, Avner Ehrlich, Boaz Gildor, Ariel Gold, Yaakov Nahmias
Spontaneously immortalized cell lines provide an essential, non-transformed resource for cultivated meat production. Although chicken fibroblasts readily immortalize in culture, bovine fibroblasts have not been shown to immortalize without genetic manipulation of TP53 or TERT. Here we demonstrate the spontaneous immortalization of fibroblast lines from Simmental and Holstein cows. We track the molecular basis of the immortalization process over 500 days of culture, corresponding to 240 population doublings. Cells entered senescence at population doubling 60, showing γH2AX foci, telomere shortening and an active senescence-associated secretory phenotype profile. Breakthroughs occurred following 400 days in culture, resulting in stable fibroblast lines. Telomerase and PGC1A activation during senescence resolve telomere shortening and mitochondrial dysfunction without activating P53, driving spontaneous immortalization. We explored the economic potential of cultivated beef production using spontaneously immortalized bovine fibroblasts, showing that price parity could be theoretically reached using continuous manufacturing. Bovine fibroblast cell line generation without genetic modification is characterized. A technoeconomic analysis demonstrates the potential for price-competitive, scaled-up cultivated beef production.
自发永生化细胞系为养殖肉类生产提供了必不可少的非转化资源。虽然鸡的成纤维细胞很容易在培养中长生不老,但牛的成纤维细胞在没有TP53或TERT基因操纵的情况下并没有表现出长生不老。在这里,我们展示了西门塔尔奶牛和荷尔斯坦奶牛成纤维细胞系的自发永生。在500天的培养过程中,我们追踪了永生过程的分子基础,相当于240个种群加倍。细胞在群体倍增60时进入衰老,显示出γ - h2ax焦点,端粒缩短和活跃的衰老相关分泌表型。培养400天后出现突破,形成稳定的成纤维细胞系。衰老过程中端粒酶和PGC1A的激活解决了端粒缩短和线粒体功能障碍,而不激活P53,从而驱动自发的永生。我们探索了利用自发永生牛成纤维细胞培育牛肉生产的经济潜力,表明使用连续生产在理论上可以达到价格平价。牛成纤维细胞系的产生没有基因修饰的特点。一项技术经济分析显示了具有价格竞争力的大规模养殖牛肉生产的潜力。
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Nature food
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