Pub Date : 2023-10-30DOI: 10.1021/cen-10136-scicon2
None Laurel Oldach
{"title":"A new tool for protein designers","authors":"None Laurel Oldach","doi":"10.1021/cen-10136-scicon2","DOIUrl":"https://doi.org/10.1021/cen-10136-scicon2","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"131 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-polcon2
None Britt E. Erickson
{"title":"NIH revamps grant review process to reduce bias","authors":"None Britt E. Erickson","doi":"10.1021/cen-10136-polcon2","DOIUrl":"https://doi.org/10.1021/cen-10136-polcon2","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"52 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-leadcon
None Priyanka Runwal
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals found in the air, water, and soil. They have contaminated drinking water, accumulated to levels of concern in some fish, and entered the bloodstreams of animals and humans, raising serious health concerns. While some PFAS are being phased out, they’re often replaced with new ones that may also be toxic. Finding and keeping track of these emerging PFAS is challenging. New research has found a way to detect them. Most commercial laboratories target about 40 PFAS, “but we know many, many more exist,” says Erin Baker, an analytical chemist at the University of North Carolina at Chapel Hill. The US Environmental Protection Agency, for example, maintains a list of more than 14,000 PFAS that may be used in making products resistant to oil, water, and heat. The problem is that “there’s only a few hundred chemical standards available to validate that
{"title":"New method spots unreported forever chemicals","authors":"None Priyanka Runwal","doi":"10.1021/cen-10136-leadcon","DOIUrl":"https://doi.org/10.1021/cen-10136-leadcon","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals found in the air, water, and soil. They have contaminated drinking water, accumulated to levels of concern in some fish, and entered the bloodstreams of animals and humans, raising serious health concerns. While some PFAS are being phased out, they’re often replaced with new ones that may also be toxic. Finding and keeping track of these emerging PFAS is challenging. New research has found a way to detect them. Most commercial laboratories target about 40 PFAS, “but we know many, many more exist,” says Erin Baker, an analytical chemist at the University of North Carolina at Chapel Hill. The US Environmental Protection Agency, for example, maintains a list of more than 14,000 PFAS that may be used in making products resistant to oil, water, and heat. The problem is that “there’s only a few hundred chemical standards available to validate that","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-scicon3
None Payal Dhar, special to C&EN
When space debris reenters the atmosphere, the heat generated from friction causes most of it to vaporize. Scientists have recently found that the vaporized metals condense as they descend, ending up in aerosol particles in the stratosphere ( Proc. Natl. Acad. Sci. U.S.A. 2023, DOI: 10.1073/pnas.2313374120 ). This discovery is part of the Stratospheric Aerosol processes, Budget, and Radiative Effects (SABRE) mission. During a series of flights in February and March, the researchers sampled the stratosphere at altitudes up to 19 km. The researchers detected almost two dozen elements that come from meteors, volcanoes, and vaporized spacecraft. Meteors are considered the main sources of sodium, magnesium, chromium, iron, and nickel, but the researchers also found aluminum, copper, lead, and lithium that could not be accounted for by natural causes. “What we measured is consistent with what we know about what spacecraft are made of,” says Daniel Murphy , an aerosols
{"title":"Metals from space debris found in stratosphere","authors":"None Payal Dhar, special to C&EN","doi":"10.1021/cen-10136-scicon3","DOIUrl":"https://doi.org/10.1021/cen-10136-scicon3","url":null,"abstract":"When space debris reenters the atmosphere, the heat generated from friction causes most of it to vaporize. Scientists have recently found that the vaporized metals condense as they descend, ending up in aerosol particles in the stratosphere ( Proc. Natl. Acad. Sci. U.S.A. 2023, DOI: 10.1073/pnas.2313374120 ). This discovery is part of the Stratospheric Aerosol processes, Budget, and Radiative Effects (SABRE) mission. During a series of flights in February and March, the researchers sampled the stratosphere at altitudes up to 19 km. The researchers detected almost two dozen elements that come from meteors, volcanoes, and vaporized spacecraft. Meteors are considered the main sources of sodium, magnesium, chromium, iron, and nickel, but the researchers also found aluminum, copper, lead, and lithium that could not be accounted for by natural causes. “What we measured is consistent with what we know about what spacecraft are made of,” says Daniel Murphy , an aerosols","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"120 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon15
None Rick Mullin
Daiichi Sankyo and Merck & Co. have signed a commercialization agreement for three of Daiichi Sankyo’s antibody-drug conjugate (ADC) candidates. The three ADCs—patritumab deruxtecan, ifinatamab deruxtecan, and raludotatug deruxtecan—are in various stages of clinical development for the treatment of multiple solid tumors as monotherapies or in combination with other treatments. The partners would jointly commercialize resulting therapies worldwide, except in Japan, where Daiichi Sankyo would be solely responsible for manufacture and supply. Merck will pay Daiichi $4 billion up front under terms of the agreement.
{"title":"Daiichi Sankyo and Merck sign ADC deal","authors":"None Rick Mullin","doi":"10.1021/cen-10136-buscon15","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon15","url":null,"abstract":"Daiichi Sankyo and Merck & Co. have signed a commercialization agreement for three of Daiichi Sankyo’s antibody-drug conjugate (ADC) candidates. The three ADCs—patritumab deruxtecan, ifinatamab deruxtecan, and raludotatug deruxtecan—are in various stages of clinical development for the treatment of multiple solid tumors as monotherapies or in combination with other treatments. The partners would jointly commercialize resulting therapies worldwide, except in Japan, where Daiichi Sankyo would be solely responsible for manufacture and supply. Merck will pay Daiichi $4 billion up front under terms of the agreement.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon3
None Alex Tullo
Slow economic activity around the world stymied third-quarter performance at Dow, the largest US chemical maker and the first major firm to report results. Dow’s sales were down 24% in the third quarter versus the year-earlier period, while net income fell 57%. Selling volumes declined by 6%, but a bigger factor in the results were prices for Dow products, which declined 18% from a year earlier—primarily the result of lower energy costs. Sales in the company’s largest business, packaging and specialty plastics, were down 26%. Demand for the segment’s key product, polyethylene, was strong, but volumes for merchant sales of chemicals were weak. Moreover, the unit saw a 20% decline in prices. The main reasons for the sluggish economic performance: Europe, which continues to show tepid growth, and China, which is experiencing a slow recovery from its COVID-19 lockdowns. But the results weren’t all negative. “Automotive, I would say, is
{"title":"Dow earnings drop on economic woes","authors":"None Alex Tullo","doi":"10.1021/cen-10136-buscon3","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon3","url":null,"abstract":"Slow economic activity around the world stymied third-quarter performance at Dow, the largest US chemical maker and the first major firm to report results. Dow’s sales were down 24% in the third quarter versus the year-earlier period, while net income fell 57%. Selling volumes declined by 6%, but a bigger factor in the results were prices for Dow products, which declined 18% from a year earlier—primarily the result of lower energy costs. Sales in the company’s largest business, packaging and specialty plastics, were down 26%. Demand for the segment’s key product, polyethylene, was strong, but volumes for merchant sales of chemicals were weak. Moreover, the unit saw a 20% decline in prices. The main reasons for the sluggish economic performance: Europe, which continues to show tepid growth, and China, which is experiencing a slow recovery from its COVID-19 lockdowns. But the results weren’t all negative. “Automotive, I would say, is","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"34 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-classifieds
{"title":"Classifieds","authors":"","doi":"10.1021/cen-10136-classifieds","DOIUrl":"https://doi.org/10.1021/cen-10136-classifieds","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"238 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-scicon5
None Katherine Bourzac, special to C&EN
{"title":"Cracking the chemical mystery of Mars’s core","authors":"None Katherine Bourzac, special to C&EN","doi":"10.1021/cen-10136-scicon5","DOIUrl":"https://doi.org/10.1021/cen-10136-scicon5","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-polcon1
None Britt E. Erickson
{"title":"EPA seeks to ban trichloroethylene","authors":"None Britt E. Erickson","doi":"10.1021/cen-10136-polcon1","DOIUrl":"https://doi.org/10.1021/cen-10136-polcon1","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"4 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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